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Lactate AND Aging

Narges Parsaie, Saeed Ghavamzadeh, Mahdi Cheraghi
OBJECTIVES: Soccer-induced muscle damage and inflammation lead to a reduction in athletic performance. The aim of this study was to determine whether supplementation with cholecalciferol would reduce inflammation and muscle damage in soccer players after a simulated soccer match. METHODS: Twenty-two soccer players (median age 27 y, interquartile range 5 y) were divided randomly into two groups, as follows: a cholecalciferol group (n = 11) and a placebo group (n = 11)...
July 12, 2018: Nutrition
Chih-Min Su, Chia-Te Kung, Fu-Cheng Chen, Hsien-Hung Cheng, Sheng-Yuan Hsiao, Yun-Ru Lai, Chin-Cheng Huang, Nai-Wen Tsai, Cheng-Hsien Lu
Background: Several comorbidities contribute to an increased risk of infections in Parkinson's disease (PD) as the disease progresses. However, few studies have examined the correlation between sepsis and PD. Aim: The aim of this study is to disclose the presentation and outcome of serious infection in patients with PD in the emergency department. Methods: This retrospective cohort study enrolled patients with PD who had serious infection and were admitted to the emergency department between January 2007 and December 2013...
2018: BioMed Research International
W J J Gerrits
Recent interest in increasing rates of body weight gain in heifer calves before weaning is based on the promise of an increase in milk production during first lactation. This increase is usually realized by increasing milk or milk replacer intake, delaying the onset of rumen development. Simultaneously feeding liquids and solid feeds brings about new challenges. Macronutrient metabolism in growing calves is reviewed, combining literature from heifer and veal calves with the objective to provide insights useful for developing novel feeding strategies...
November 8, 2018: Journal of Dairy Science
Agnieszka Żelaźniewicz, Bogusław Pawłowski
OBJECTIVES: Successful breastfeeding, crucial for a child's development, depends on a woman's ability to initiate lactation, milk yield, and composition. Those traits differ among women, but the cause and physiological mechanisms responsible for this variation are not fully understood yet. Growing evidence shows that lactation and milk composition vary among women and depend on maternal traits. The aim of this study was to test whether breast volume and its changes during pregnancy are related to the nutritional quality of breastmilk and to breastfeeding dynamics...
November 8, 2018: American Journal of Physical Anthropology
Maria L Gianni, Paola Roggero, Fabio Mosca
PURPOSE OF REVIEW: We review the current available evidence on the metabolic fate of human milk proteins and their potential clinical implications for growth and body composition development vs. those of formula proteins in preterm infants. RECENT FINDINGS: The decreased content of human milk protein in preterm mothers throughout lactation might contribute to the reduced growth reported in exclusively human milk-fed infants compared with that of formula-fed infants...
November 6, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
Amanda P Pedroso, Ana P S Dornellas, Adriana P de Souza, Josias F Pagotto, Lila M Oyama, Cláudia M O Nascimento, Jelena Klawitter, Uwe Christians, Alexandre K Tashima, Eliane Beraldi Ribeiro
PURPOSE: Intrauterine growth restriction (IUGR) has been shown to induce the programming of metabolic disturbances and obesity, associated with hypothalamic derangements. The present study aimed at investigating the effects of IUGR on the protein and metabolite profiles of the hypothalamus of adult female rats. METHODS: Wistar rats were mated and either had ad libitum access to food (control group) or received only 50% of the control intake (restricted group) during the whole pregnancy...
November 7, 2018: European Journal of Nutrition
Chulananda D A Goonasekera, Joseph A Carcillo, Akash Deep
Background: In septic shock, both oxygen delivery (DO2 ) and oxygen consumption (VO2 ) are dysfunctional. The current therapeutic regimens are geared to normalize global oxygen delivery (DO2 ) to tissues via goal directed therapies but mortality remains high at 10-20%. Methods: We studied cardiac index (CI), systemic vascular resistance index (SVRI), central venous oxygen saturation (ScvO2), central venous pressure (CVP), peripheral oxygen saturation (SpO2), mean blood pressure (MBP), body temperature, blood lactate, base excess and hemoglobin concentration (Hb) in a cohort of children admitted in "fluid-refractory" severe septic shock to pediatric intensive care, over 4...
2018: Frontiers in Pediatrics
Fane F K Mensah, Christopher W Armstrong, Venkat Reddy, Amolak S Bansal, Saul Berkovitz, Maria J Leandro, Geraldine Cambridge
CD24 expression on pro-B cells plays a role in B cell selection and development in the bone marrow. We previously detected higher CD24 expression and frequency within IgD+ naïve and memory B cells in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) compared with age-matched healthy controls (HC). Here, we investigated the relationship between CD24 expression and B cell maturation. In vitro stimulation of isolated B cells in response to conventional agonists were used to follow the dynamics of CD24 positivity during proliferation and differentiation (or maturation)...
2018: Frontiers in Immunology
Sujay Samanta, Ratender Kumar Singh, Arvind K Baronia, Prabhaker Mishra, Banani Poddar, Afzal Azim, Mohan Gurjar
Aim of the Study: Metabolic acidosis is associated with increased mortality in critically ill patients. We hypothesized that early correction of acidosis of presumed metabolic origin results in improved outcomes. Patients and Methods: We conducted a prospective, observational study from February 2015 to June 2016 in a 12 bed mixed intensive care unit (ICU) of a 1000 bed tertiary care hospital in the north of India. ICU patients aged above 18 years with an admission pH ≥7...
October 2018: Indian Journal of Critical Care Medicine
Dagmar M Ouweneel, Justin de Brabander, Mina Karami, Krischan D Sjauw, Annemarie E Engström, M Marije Vis, Joanna J Wykrzykowska, Marcel A Beijk, Karel T Koch, Jan Baan, Robbert J de Winter, Jan J Piek, Wim K Lagrand, Thomas Gv Cherpanath, Antoine Hg Driessen, Riccardo Cocchieri, Bas Ajm de Mol, Jan Gp Tijssen, José Ps Henriques
AIMS: Mortality in cardiogenic shock patients remains high. Short-term mechanical circulatory support with Impella can be used to support the circulation in these patients, but data from randomised controlled studies and 'real-world' data are sparse. The aim is to describe real-life data on outcomes and complications of our 12 years of clinical experience with Impella in patients with cardiogenic shock after acute myocardial infarction and to identify predictors of 6-month mortality. METHODS: We describe a single-centre registry from October 2004 to December 2016 including all patients treated with Impella for cardiogenic shock after acute myocardial infarction...
November 7, 2018: European Heart Journal. Acute Cardiovascular Care
Thomas Fux, Manne Holm, Matthias Corbascio, Lars H Lund, Jan van der Linden
Refractory cardiogenic shock (RCS) is associated with a high mortality. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used as acute cardiopulmonary support but selection of VA-ECMO candidates remains challenging. There are limited data on which pre-VA-ECMO variables that predict outcome. The aim of this study was to identify pre-VA-ECMO predictors of 90-day mortality. We retrospectively analyzed 76 consecutive patients (median age 52; interquartile range [IQR]: 37-60) supported with VA-ECMO due to RCS...
November 6, 2018: Artificial Organs
Xiangyang Cheng, Jing Hu, Ya Wang, Hongwei Ye, Xiaohong Li, Qin Gao, Zhenghong Li
Objective: The present study was designed to determine whether dexmedetomidine (DEX) exerts cardioprotection against myocardial I/R injury in diabetic hearts and the mechanisms involved. Methods: A total of 30 diabetic rats induced by high-glucose-fat diet and streptozotocin (STZ) were randomly assigned to five groups: diabetic sham-operated group (DM-S), diabetic I/R group (DM-I/R), diabetic DEX group (DM-D), diabetic DEX + Wort group (DM-DW), and diabetic Wort group (DM-W)...
2018: Journal of Diabetes Research
Fabio Mosca, Paola Roggero, Francesca Garbarino, Daniela Morniroli, Beatrice Bracco, Laura Morlacchi, Domenica Mallardi, Maria Lorella Gianni, Dario Consonni
BACKGROUND: Among breastfeeding determinants, the marketing of breast milk substitutes might contribute to suboptimal breastfeeding rates. The aim of this study was to investigate the effect of receiving information on breast milk substitutes on breastfeeding rates. METHODS: We conducted a randomized, single-blind, controlled trial from 2012 to 2014 in a northern Italian maternity ward. We enrolled 802 Caucasian mothers who gave birth to healthy, full-term singletons with a birth weight > 2500 g and who were exclusively breastfeeding from delivery to discharge...
November 6, 2018: Italian Journal of Pediatrics
Y Zhou, X Xu, H Xu, G H Cui, L Zhang
Objective: The aim of this study is to explore the clinicopathological features and treatment outcome of primary thyroid lymphoma(PTL). Method: Clinicopathological data of 37 cases of PTL were retrospectively reviewed, and analyzed in combined with followup data. Result: Of the 37 patients, Hashimoto's disease was diagnosed in 28(75.7%) patients. The diagnostic rate of preoperative fine needle biopsy (75%) was higher than the fine needle aspiration (53%). The pathological types of these patients included diffuse large B cell lymphoma( n =23), extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue type (MALT) ( n =10), follicular lymphoma(FL) grade 3 ( n =3) and burkitt lymphoma(BL) ( n =1)...
October 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Toshiharu Natsume, Toshinori Yoshihara, Hisashi Naito
Neuromuscular electrical stimulation (NMES) combined with blood flow restriction (BFR) induces muscle hypertrophy. However, cellular mechanisms underlying the muscle hypertrophy induced by NMES combined with BFR remain unclear. We tested the hypothesis that NMES combined with BFR would enhance the mechanistic target of rapamycin (mTOR) and mitogen activated protein kinase (MAPK) signaling pathways. Age-matched male Wistar rats (6 months old, n=7 per group) were assigned randomly into control, BFR alone (BFR), NMES alone (NMES) and NMES combined with BFR (NMES/BFR) groups...
November 6, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Cary Ma, L Cynthia Gunaratnam, Austin Ericson, Andrea L Conroy, Sophie Namasopo, Robert O Opoka, Michael T Hawkes
Globally, pneumonia is the leading cause of death among children younger than 5 years old, with most deaths occurring in low-income countries. Rapid bedside tools to assist practitioners to accurately triage and risk-stratify these patients may improve clinical care and patient outcomes. We conducted a prospective cohort study of children with pneumonia admitted to two Ugandan hospitals to examine the predictive value of a single point-of-care lactate measurement using a commercially available handheld device, the Lactate Scout Analyzer...
November 5, 2018: American Journal of Tropical Medicine and Hygiene
Rachael Hall, Kate Gardner, David C Rees, Subarna Chakravorty
Objective: To assess the prevalence of high body mass index (BMI) in children with sickle cell disease and assess correlation between BMI and disease severity. Design: Retrospective chart review followed by statistical analysis. Setting: A single tertiary paediatric clinic in inner city London. Patients: All patients with sickle cell disease, including homozygous haemoglobin (HbSS) and compound heterozygous Hb (HbSC), age 2-18 years receiving clinical care at the centre, were included in the study...
2018: BMJ Paediatrics Open
D Hassoun
OBJECTIVE: To develop clinical practice recommendations for the use of natural contraception and female and male barrier methods. MATERIALS AND METHODS: A systematic review of English and French literatures related to the safety and effectiveness of natural contraceptive methods based on PubMed, Cochrane Library, practice recommendations issued by international scientific societies and guidelines provided by the World Health Organization (WHO) as well as updates from the Center for Disease Control and Prevention (CDC)...
October 30, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
Vanesa Natalin Rocha Martin, Clarissa Schwab, Lukasz Krych, Evelyn Voney, Annelies Geirnaert, Christian Braegger, Christophe Lacroix
Establishment of the infant gut microbiota affects gut maturation and influences long-term health. Cutibacterium (formerly Propionibacterium) have been identified as early colonizers, but little is known about their function. Using a cultivation-dependent and -independent approach, we determined Cutibacterium prevalence, diversity and functional potential. In feces from a Swiss infant cohort (n = 38), prevalence of Propionibacterium/Cutibacterium decreased from 84% at 2 weeks, to 65% at 4 weeks, 47% at 8 weeks and 41% at 12 weeks of age...
November 1, 2018: FEMS Microbiology Ecology
Billy Sperlich, Ine De Clerck, Christoph Zinner, Hans-Christer Holmberg, Birgit Wallmann-Sperlich
The aim was to examine certain aspects of circulatory, metabolic, hormonal, thermoregulatory, cognitive, and perceptual responses while sitting following a brief session of high-intensity interval exercise. Twelve students (five men; age, 22 ± 2 years) performed two trials involving either simply sitting for 180 min (SIT) or sitting for this same period with a 6-min session of high-intensity exercise after 60 min (SIT+HIIT). At T0 (after 30 min of resting), T1 (after a 20-min breakfast), T2 (after sitting for 1 h), T3 (immediately after the HIIT), T4 , T5 , T6 , and T7 (30, 60, 90, and 120 min after the HIIT), circulatory, metabolic, hormonal, thermoregulatory, cognitive, and perceptual responses were assessed...
2018: Frontiers in Physiology
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