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https://www.readbyqxmd.com/read/30016349/nmr-based-metabolic-profiling-of-urine-serum-fecal-and-pancreatic-tissue-samples-from-the-ptf1a-cre-lsl-krasg12d-transgenic-mouse-model-of-pancreatic-cancer
#1
Michelle J Schmahl, Daniel P Regan, Adam C Rivers, William C Joesten, Michael A Kennedy
Pancreatic cancer is the third leading cause of cancer deaths in the United States with more than 53,000 expected to be diagnosed with the disease in 2018. The median survival time after diagnosis is four to six months. The poor survival statistics are due in part to the fact that pancreatic cancer is typically asymptomatic until it reaches advanced stages of the disease. Although surgical resection provides the best chance of survival, pancreatic cancer is rarely detected when surgery is still possible due, in part, to lack of effective biomarkers for early detection...
2018: PloS One
https://www.readbyqxmd.com/read/30015516/the-association-between-plasma-mir-122-5p-release-pattern-at-admission-and-all-cause-mortality-or-shock-after-out-of-hospital-cardiac-arrest
#2
Patrik Gilje, Martin Frydland, John Bro-Jeppesen, Josef Dankiewicz, Hans Friberg, Malin Rundgren, Yvan Devaux, Pascal Stammet, Mariam Al-Mashat, Jonas Jögi, Jesper Kjaergaard, Christian Hassager, David Erlinge
BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls...
July 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30015396/risk-stratification-of-high-risk-metastatic-neuroblastoma-a-report-from-the-hr-nbl-1-siopen-study
#3
Daniel A Morgenstern, Ulrike Pötschger, Lucas Moreno, Vassilios Papadakis, Cormac Owens, Shifra Ash, Claudia Pasqualini, Roberto Luksch, Alberto Garaventa, Adela Canete, Martin Elliot, Aleksandra Wieczorek, Geneviève Laureys, Per Kogner, Josef Malis, Ellen Ruud, Maja Beck-Popovic, Gudrun Schleiermacher, Dominique Valteau-Couanet, Ruth Ladenstein
BACKGROUND: Risk stratification is crucial to treatment decision-making in neuroblastoma. This study aimed to explore factors present at diagnosis affecting outcome in patients aged ≥18 months with metastatic neuroblastoma and to develop a simple risk score for prognostication. PROCEDURE: Data were derived from the European high-risk neuroblastoma 1 (HR-NBL1)/International Society for Paediatric Oncology European Neuroblastoma (SIOPEN) trial with analysis restricted to patients aged ≥18 months with metastatic disease and treated prior to the introduction of immunotherapy...
July 17, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30014928/evaluation-of-placental-vascularization-indices-in-monochorionic-diamniotic-and-dichorionic-diamniotic-twin-pregnancies
#4
Ábel Tamás Altorjay, Tibor Nyári, Zita Gyurkovits, Gábor Németh, Andrea Surányi
OBJECTIVES: We aimed to investigate and compare placental vascularization indices between monochorionic-diamniotic, dichorionic-diamniotic normal twin pregnancies, and normal singular pregnancies. We hypothesized that there is correlation between placental three-dimensional power Doppler vascularization indices and birth weight in case of twin pregnancies, and that normal singular pregnancies have higher placental vascularization indices than normal twin pregnancies. STUDY DESIGN: Placental three-dimensional power Doppler vascularization indices, such as vascularization index, flow index, and vascularization-flow index were measured in monochorionic-diamniotic (N = 15) and dichorionic-diamniotic (N = 36) normal twin pregnancies, and in normal singular (N = 109) pregnancies...
June 1, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/30014285/calculation-of-an-adequate-intake-ai-value-and-safe-range-of-selenium-se-for-chinese-infants-0-3-months-old-based-on-se-concentration-in-the-milk-of-lactating-chinese-women-with-optimal-se-intake
#5
Feng Han, Liping Liu, Jiaxi Lu, Yingjuan Chai, Jie Zhang, Shijin Wang, Licui Sun, Qin Wang, Yiqun Liu, Mengjie He, Weipeng Mu, Zhenwu Huang
The required selenium intake for optimal health in Chinese residents was published in 2014. However, the adequate intake (AI) value for Chinese infants 0-3 months old is not established. This study assessed the current selenium nutritional status of 264 lactating Chinese women from three geographical locations with different Se levels (Liangshan in Sichuan province, Enshi in Hubei province, and Xicheng District in Beijing), to screen mothers with optimal Se intake, and to modify the AI value of Se for Chinese infants 0-3 months old...
July 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/30008818/metabolic-tumor-volume-changes-assessed-by-interval-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-the-prediction-of-complete-response-and-survival-in-patients-with-diffuse-large-b-cell-lymphoma
#6
Luis F Oñate-Ocaña, Violeta Cortés, Rodrigo Castillo-Llanos, Andrea Terrazas, Osvaldo Garcia-Perez, Quetzalli Pitalúa-Cortes, Mayra Ponce, Alfonso Dueñas-Gonzalez, Myrna Candelaria
An early discrimination of survival probability is required for patients with diffuse large B cell lymphoma (DLBCL), which may identify patients that require other treatment options, for example clinical trials. To the best of our knowledge, the impact of interim evaluation with 18 fluorodeoxyglucose positron emission tomography-computed tomography (18 F-FDG PET/CT) has not yet been determined in this type of neoplasia. The aim of the present study was to determine the role of changes in metabolic tumor volume (MTV) between baseline and interim 18 F-FDG PET/CT scans, following three courses of chemotherapy in order to predict complete response (CR) and overall survival (OS) in patients with DLBCL...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30008799/ischemic-colitis-caused-increased-early-and-delayed-mortality
#7
Hayim Gilshtein, Kenan Hallon, Yoram Kluger
Background: Ischemic colitis remains a challenge for the surgeon, both in its diagnosis and treatment. Data from a single tertiary center, of patients diagnosed with ischemic colitis, was collected. An attempt was made to delineate the patients requiring surgical intervention. Methods: A retrospective study was undertaken in patients diagnosed with ischemic colitis admitted to Rambam Health Care Campus between 2011 and 2016. The primary outcome was defined as mortality...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/30007130/brain-derived-neurotrophic-factor-in-serum-as-an-animal-welfare-indicator-of-environmental-enrichment-in-pigs
#8
J-L Rault, A J Lawrence, C R Ralph
Environment enrichment is a rising topic for animal welfare but measures to identify effective enrichment interventions are lacking. In humans and rodent species, environmental enrichment increases brain-derived neurotrophic factor (BDNF), the most abundant neurotrophin in the brain. Higher BDNF concentration is ultimately linked to higher stress resilience, and BDNF in the hippocampus enhances learning and memory. In addition, BDNF concentrations in the brain and blood are correlated, offering the opportunity to use peripheral BDNF as a minimally invasive measure of effective enrichment reflecting neural changes...
June 4, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/30007015/nicotinamide-riboside-supplementation-dysregulates-redox-and-energy-metabolism-in-rats-implications-for-exercise-performance
#9
I A Kourtzidis, C F Dolopikou, A N Tsiftsis, N V Margaritelis, A A Theodorou, I A Zervos, M P Tsantarliotou, A S Veskoukis, I S Vrabas, V Paschalis, A Kyparos, M G Nikolaidis
NEW FINDINGS: What is the central question of this study? To investigate the potential metabolic and redox mechanisms that impaired exercise performance after a 21-day supplementation with 300 mg/kg body weight of nicotinamide riboside in rats. What is the main finding and its importance? Nicotinamide riboside disturbed energy and redox metabolism and impaired exercise performance in heathy rats. Exogenously administered redox agents in heathy populations may lead to adverse effects...
July 14, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/30006661/-importance-of-phototherapy-in-the-treatment-of-chronic-pruritus
#10
REVIEW
Franz J Legat
Phototherapy and photochemotherapy (PUVA) are important treatment modalities in inflammatory skin diseases such as psoriasis and atopic dermatitis as well as in cutaneous T‑cell lymphoma (e.g., mycosis fungoides/Sezary syndrome). Many of these skin diseases are accompanied by distracting pruritus. In addition, patients may suffer from intense pruritus in systemic diseases of the kidney and liver as well as of the endocrine and hematopoietic system. UV-light during phototherapy is capable of not only improving the inflammatory skin lesions but also of reducing the pruritus in skin and systemic diseases...
July 13, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/30006285/the-pretreatment-albumin-to-globulin-ratio-as-a-significant-predictor-in-patients-with-diffuse-large-b-cell-lymphoma
#11
Wenqin Yue, Bin Liu, Lei Gao, Miaoxia He, Jianmin Wang, Weiping Zhang, Li Chen, Xiaoxia Hu, Lili Xu, Jianmin Yang
BACKGROUND: The pretreatment albumin to globulin ratio (AGR) has been used to predict survival in several types of tumors. However, whether AGR can predict outcomes in patients with diffuse large B-cell lymphoma (DLBCL) remains unclear. We evaluated the prognosis value of AGR in DLBCL patients. METHODS: We retrospectively analyzed the available serum biochemical results of 335 patients with newly diagnosed DLBCL before treatment. The AGR was calculated as: albumin (g/L)/globulin...
July 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30001950/development-and-external-validation-of-an-early-prognostic-model-for-survivors-of-out-of-hospital-cardiac-arrest
#12
Alberto Pérez-Castellanos, Manuel Martínez-Sellés, Aitor Uribarri, Carolina Devesa-Cordero, José Carlos Sánchez-Salado, Albert Ariza-Solé, Iago Sousa, Miriam Juárez, Francisco Fernández-Avilés
INTRODUCTION AND OBJECTIVES: Despite therapeutic hypothermia, unconscious survivors of out-of-hospital cardiac arrest have a high risk of death or poor neurologic function. Our objective was to assess the usefulness of the variables obtained in the early moments after resuscitation in the prediction of 6-month prognosis. METHODS: A multicenter study was performed in 3 intensive cardiac care units. The analysis was done in 153 consecutive survivors of out-of-hospital cardiac arrest who underwent targeted temperature management between January 2007 and July 2015...
July 9, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29999581/ovarian-hormones-modulate-endothelin-1-receptor-responses-in-young-women
#13
Kelly N Sebzda, Andrew V Kuczmarski, Ryan T Pohlig, Shannon L Lennon, David G Edwards, Megan M Wenner
OBJECTIVE: We recently demonstrated endothelin-B receptors (ETBR ) mediate vasodilation in young but not postmenopausal women; it is unclear if this is related to age or a decline in ovarian hormones. The purpose of this study was to test the hypothesis that ETBR responses are modulated by ovarian hormones. METHODS: We measured cutaneous vasodilatory responses in 12 young women (22±1 years, 23±1 kg/m2 ) during the mid-luteal (ML; days 20-25) and early follicular (EF; days 2-5) phases of the menstrual cycle...
July 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29996843/%C3%AE-alanine-supplementation-increased-physical-performance-and-improved-executive-function-following-endurance-exercise-in-middle-aged-individuals
#14
Taylor Furst, Alyssa Massaro, Courtney Miller, Brian T Williams, Zach M LaMacchia, Peter J Horvath
BACKGROUND: Sarcopenia, a reduction in muscle mass and function seen in aging populations, may be countered by improving systemic carnosine stores via beta-Alanine (β-alanine) supplementation. Increasing systemic carnosine levels may result in enhanced anti-oxidant, neuro-protective and pH buffering capabilities. This enhancement should result in improved exercise capacity and executive function. METHODS: Twelve healthy adults (average age = 60.5 ± 8.6 yrs, weight = 81...
July 11, 2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29996382/-relationship-between-neutrophil-to-lymphocyte-ratio-and-myocardial-injury-induced-by-acute-carbon-monoxide-poisoning
#15
Y Y Han, Y Wang, G Q Zhao, J L Yang, L Wang, W Z Wang
Objective: To investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and myocardial injury induced by acute carbon monoxide poisoning. Methods: A retrospective analysis was performed on 214 patients with acute carbon monoxide poisoning who were admitted to Emergency Depart-ment of Harrison International Peace Hospital, Hebei Medical University, from 2015 to 2017. According to the diagnostic criteria for toxic heart disease and the level of cardiac troponin I (cTnI), a biomarker of cardiac injury, these patients were divided into myocardial injury group (n = 84) and non-myocardial injury group (n=130)...
May 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29996349/-analysis-of-15-cases-of-avian-influenza-virus-h7n9-infection
#16
W Q Yu, M D Ding, G H Dai, C J Gu, L Xue, Y Chen, D M Zhou, J C Xian, H T Xu
Objective: To describe the clinical, chest imaging, pathological manifestations and therapeutic experience of human infection with A/H7N9 virus. Methods: The features of 15 laboratory-confirmed cases of human infection with A/H7N9 virus in Taizhou, Jiangsu Province were retrospectively analyzed. Results: The 15 patients with confirmed viral pneumonia included 12 males and 3 females, with a median age of 61 years(ranging from 33 to 81 years). Twelve patients had a history of exposure to the poultry trading places, or direct contact with ill/dead avian, while 3 patients denied exposure or contact...
July 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29993054/lactoferrin-level-in-breast-milk-a-study-of-248-samples-from-eight-regions-in-china
#17
Xiaokun Cai, Yifan Duan, Yang Li, Jie Wang, Yingyi Mao, Zhenyu Yang, Xianfeng Zhao, Yanrong Zhao, Yan Guan, Shian Yin
Lactoferrin plays an important role in infant gastrointestinal health and immunity responses. This study measured the change of the lactoferrin level in breast milk over the lactation time in Chinese women, and explored potential influencing factors in terms of various maternal factors. 248 lactating women were recruited from eight different regions across China, covering 330 days of lactation. The nutrition information of each woman as well as the gender information of infants were collected. Breast milk lactoferrin level was determined by ultra-performance liquid chromatography (UPLC)...
July 11, 2018: Food & Function
https://www.readbyqxmd.com/read/29992930/-modern-approaches-to-components-of-therapy-of-patients-with-diabetes-mellitus-operated-on-for-malignant-neoplasms-of-small-pelvic-organs
#18
S V Tumanyan, A V Shepelenko, S A Chekmezova
The purpose of this study was assessment of the effect of cytoflavin preparation inclusion in surgical treatment of patients with malignant neoplasms of small pelvic organs and diabetes mellitus. A prospective examination of 51 patients aged 56 to 76 years suffering from diabetes mellitus and malignant neoplasms of the pelvic organs was performed. Patients were divided into two groups: the first group consisted of 27 patients whose adaptive potential was characterized by tension of adaptation mechanisms, the second one - 24 patients with poor adaptation...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29991566/maternal-low-protein-diet-programmes-low-ovarian-reserve-in-offspring
#19
Amy L Winship, Sarah E Gazzard, Luise A Cullen McEwen, John F Bertram, Karla J Hutt
The ovarian reserve of primordial follicle oocytes is formed during in utero development and represents the entire supply of oocytes available to sustain female fertility. Maternal undernutrition during pregnancy and lactation diminishes offspring ovarian reserve in rats. In mice, maternal oocyte maturation is also susceptible to undernutrition, causing impaired offspring cardiovascular function. We aimed to determine whether programming of the ovarian reserve is impacted in offspring when maternal undernutrition extends from preconception oocyte development through to weaning...
July 10, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29991377/nurse-sow-strategies-in-the-domestic-pig-ii-consequences-for-piglet-growth-suckling-behaviour-and-sow-nursing-behaviour
#20
O Schmitt, E M Baxter, L A Boyle, K O'Driscoll
Nurse sow strategies are used to manage large litters on commercial pig farms. However, new-born piglets transferred to nurse sows in late lactation might be compromised in terms of growth and survival. We investigated the effects of two nurse sow strategies on piglet growth, suckling behaviour and sow nursing behaviour. At 1-day post-farrowing, the four heaviest piglets from large litters were transferred to a nurse sow either 21 (1STEP21, n=9 litters) or 7 (2STEP7, n=10 litters) days into lactation. The remainder of the litter remained with their mother and was either kept intact (remain intact (RI), n=10 litters) or had some piglets cross-fostered to equalise birth weights (remain equalised (RE), n=9 litters)...
July 11, 2018: Animal: An International Journal of Animal Bioscience
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