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Lactate AND Aging

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https://www.readbyqxmd.com/read/29353262/preterm-human-milk-macronutrient-concentration-is-independent-of-gestational-age-at-birth
#1
Jan Maly, Iva Burianova, Veronika Vitkova, Eva Ticha, Martina Navratilova, Eva Cermakova
OBJECTIVE: To evaluate the amount of macronutrients in aggregate of human milk samples after preterm delivery during the first 2 months of lactation. METHODS: Analysis of the donated single milk samples, gained by complete emptying of the whole breast at the same daytime between 24+0 and 35+6 gestational age (GA), was designed as prospective observational cohort trial. Two milk samples were analysed every postnatal week up to the discharge from the hospital, week 9 or loss of lactation...
January 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29351580/maternal-nutrient-restriction-impairs-young-adult-offspring-ovarian-signaling-resulting-in-reproductive-dysfunction-and-follicle-loss
#2
K A Chan, P A Jazwiec, W Gohir, J J Petrik, D M Sloboda
Reproductive abnormalities are included as health complications in offspring exposed to poor prenatal nutrition. We have previously shown in a rodent model, that offspring born to nutrient restriction during pregnancy are born small, enter puberty early, and display characteristics of early ovarian aging as adults. The present study investigated whether key proteins involved in follicle recruitment and growth mediate ovarian follicle loss. Pregnant rats were randomized to: a standard diet throughout pregnancy and lactation (CON), or a calorie-restricted (50% of control) diet (UN) during pregnancy...
January 17, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29348870/n%C3%AE%C2%B5-carboxymethyl-lysine-promotes-calcium-deposition-in-vsmcs-via-intracellular-oxidative-stress-induced-pdk4-activation-and-alters-glucose-metabolism
#3
Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Yi Zhu, Nai-Feng Liu
Diabetes and vascular calcification are intrinsically linked. We previously reported that advanced glycation end products (AGEs) accelerate calcium deposition in vascular smooth muscle cells (VSMCs) via excessive oxidative stress. However, the underlying mechanism remains poorly understood. Pyruvate dehydrogenase kinase 4 (PDK4) is an important mitochondrial matrix enzyme in cellular energy metabolism. Since hyperactivation of PDK4 has been reported in calcified vessels and in patients with diabetes mellitus, inhibition of PDK4 expression may be a strategy for the prevention of diabetic vascular calcification...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348421/patients-over-40-years-old-with-precursor-t-cell-lymphoblastic-lymphoma-have-different-prognostic-factors-comparing-to-the-youngers
#4
Meng Dong, Xudong Zhang, Zhenzhen Yang, Shaoxuan Wu, Mijing Ma, Zhaoming Li, Yu Chang, Xinhua Wang, Ling Li, Xin Li, Mingzhi Zhang, Qingjiang Chen
This study aimed to analyze the clinical characteristics and prognostic factors of patients, divided into over 40-year-old group or not, with precursor T-cell lymphoblastic lymphoma (Pre-T-LBL). Based on the retrospective analysis of the clinical data of 59 patients with Pre-T-LBL during the period from December 2010 to December 2015, albumin level, anemia, pleural or pericardial effusion, protocol, therapy response, mediastinal mass, lactate dehydrogenase (LDH), and international prognostic index (IPI) or age-adjusted international prognostic index (aaIPI) were summarized...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347907/blood-lactate-is-a-predictor-of-short-term-mortality-in-patients-with-myocardial-infarction-complicated-by-heart-failure-but-without-cardiogenic-shock
#5
Grunde Gjesdal, Oscar Ö Braun, J Gustav Smith, Fredrik Scherstén, Patrik Tydén
BACKGROUND: Mortality in patients with acute myocardial infarction (AMI) has improved substantially with modern therapy including percutaneous coronary interventions (PCI) but remains high in certain subgroups such as patients presenting with overt cardiogenic shock. However, the risk for AMI in patients presenting acutely with signs of heart failure but without cardiogenic shock is less well described. We aimed to identify risk factors for mortality in AMI patients with heart failure without overt cardiogenic shock...
January 18, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29345161/caffeine-improves-triathlon-performance-a-field-study-in-males-and-females
#6
Sunita Potgieter, Hattie H Wright, Carine Smith
The ergogenic effect of caffeine on endurance exercise is commonly accepted. We aimed to elucidate realistically the effect of caffeine on triathlon event performance using a field study design, while allowing investigation into potential mechanisms at play. A double-blind, randomized, crossover, field trial was conducted. Twenty-six triathletes (14 males, 12 females) participated (age: 37.8±10.6 years, habitual caffeine intake: 413±505 mg/day, percentage body fat: 14.5±7.2%, training/week: 12.8±4.5 hours)...
January 18, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29345041/serum-amyloid-a-procalcitonin-highly-sensitive-c-reactive-protein-and-tumor-necrosis-factor-alpha-levels-and-acute-inflammatory-response-in-patients-with-hemolysis-elevated-liver-enzymes-low-platelet-count-hellp-and-eclampsia
#7
Kazım Uckan, Hanım Guler Sahin
AIM: The aim of this study was to determine the relationship between serum amyloid A (SAA), procalcitonin (ProC), highly sensitive C reactive protein (hsCRP) and tumor necrosis factor (TNF) alpha activity in patients with pre-eclampsia, eclampsia and hemolysis, elevated liver enzymes, low platelet count (HELLP), and the pathogenesis and severity of the disease. METHOD: Ninety patients at ≥ 32 gestational weeks, according to the last date of menstruation and ultra-sonographic measurements, diagnosed with pre-eclampsia (30 patients), eclampsia (30 patients) or HELLP syndrome (30 patients) were included in the study...
January 18, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29344657/effects-of-hereditary-moderate-high-fat-diet-on-metabolic-performance-and-physical-endurance-capacity-in-c57bl-6-offspring
#8
Fang Liu, Guirong Zhang, Xue Sheng, Shang Liu, Meng Cui, Heyun Guo, Jianbin Xue, Lingyun Zhang
Obesity in pregnant women presents a risk to fetal health, leading to numerous metabolic syndromes and chronic inflammation risks. Previously, physical exercise was considered to be one of the primary treatments for obesity. However, the effect of fat consumption throughout the life cycle on physical endurance capacity remains unknown. A total of two groups of female mice (age, 6 weeks; C57BL/6J) were fed with a normal chow diet and a moderate high fat diet (MHFD), during pregnancy and lactation (8 weeks), with the offspring receiving the same diet as the mother...
January 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29344353/effects-of-tnf-receptor-blockade-on-in-vitro-cell-survival-and-response-to-negative-energy-balance-in-dairy-cattle
#9
C A Martel, L K Mamedova, J E Minton, M Garcia, C Legallet, B J Bradford
Background: Associative data and some controlled studies suggest that the inflammatory cytokine tumor necrosis factor (TNF) α can induce fatty liver in dairy cattle. However, research demonstrating that TNFα is a necessary component in the etiology of bovine fatty liver is lacking. The aim of this work was to evaluate whether blocking TNFα signaling with a synthetic cyclic peptide (TNF receptor loop peptide; TRLP) would improve liver metabolic function and reduce triglyceride accumulation during feed restriction...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29344053/an-overview-of-exposure-to-ethanol-containing-substances-and-ethanol-intoxication-in-children-based-on-three-illustrated-cases
#10
REVIEW
Kam Lun Hon, Alexander Kc Leung, Eddie Cheung, Bryan Lee, Michelle Mc Tsang, Alcy R Torres
Alcohol addiction and intoxication are major health problems worldwide. Acute alcohol intoxication is well reported in adults and adolescents but less frequently reported in children of younger ages. We report three anonymized cases of pediatric ethanol exposure and illustrate the different mechanisms of intoxication. In all cases, a focused history is the key to prompt diagnosis and timely management. Physicians should be aware of this potential poison in children presented with acute confusional or encephalopathic state...
2018: Drugs in Context
https://www.readbyqxmd.com/read/29342867/a-longitudinal-study-of-25-hydroxy-vitamin-d-and-parathyroid-hormone-status-throughout-pregnancy-and-exclusive-lactation-in-new-zealand-mothers-and-their-infants-at-45%C3%A2-s
#11
Benjamin J Wheeler, Barry J Taylor, Michel de Lange, Michelle J Harper, Shirley Jones, Adel Mekhail, Lisa A Houghton
Vitamin D status and associated metabolism during pregnancy and lactation have been assessed in only a limited number of longitudinal studies, all from the northern hemisphere, with no infant data concurrently reported. Therefore, we aimed to describe longitudinal maternal and infant 25-hydroxy vitamin D (25OHD) and parathyroid hormone (PTH) status during pregnancy and up to 5 months postnatal age, in New Zealand women and their infants living at 45° S latitude. Between September 2011 and June 2013, 126 pregnant women intending to exclusively breastfeed for at least 20 weeks were recruited...
January 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29341225/past-and-present-mercury-accumulation-in-the-lake-baikal-seal-temporal-trends-effects-of-life-history-and-toxicological-implications
#12
Amanda E Poste, Mikhail V Pastukhov, Hans Fredrik Veiteberg Braaten, Ted Ozersky, Marianne Moore
Despite global efforts to reduce anthropogenic mercury (Hg) emissions, the timescale and degree to which Hg concentrations in the environment and biota respond to decreased emissions remains challenging to assess or predict. Here we characterize long-term trends, life-history patterns in Hg accumulation and toxicological implications of Hg contamination for a freshwater seal from one of the world's largest lakes (Lake Baikal, Siberia) using contemporary tissues and archival teeth. Stable isotope analysis and Hg analyses of soft tissues (muscle, liver, kidney, blood, brain, heart) and teeth from 22 contemporary seals revealed rapid changes in diet and Hg accumulation in the first year of life with a stable diet and increase in tissue Hg throughout the rest of life...
January 17, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29340577/lactation-duration-and-progression-to-diabetes-in-women-across-the-childbearing-years-the-30-year-cardia-study
#13
Erica P Gunderson, Cora E Lewis, Ying Lin, Mike Sorel, Myron Gross, Stephen Sidney, David R Jacobs, James M Shikany, Charles P Quesenberry
Importance: Lactation duration has shown weak protective associations with incident diabetes (3%-15% lower incidence per year of lactation) in older women based solely on self-report of diabetes, studies initiated beyond the reproductive period are vulnerable to unmeasured confounding or reverse causation from antecedent biochemical risk status, perinatal outcomes, and behaviors across the childbearing years. Objective: To evaluate the association between lactation and progression to diabetes using biochemical testing both before and after pregnancy and accounting for prepregnancy cardiometabolic measures, gestational diabetes (GD), and lifestyle behaviors...
January 16, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29339992/effects-of-passive-and-active-rest-on-physiological-responses-and-time-motion-characteristics-in-different-small-sided-soccer-games
#14
Ersan Arslan, Utku Alemdaroglu, Yusuf Koklu, Tahir Hazir, Surhat Muniroglu, Baris Karakoc
The purpose of this study was to investigate the effects of resting regimes on physiological responses and time motion characteristics between bouts during small sided games (SSGs) in young soccer players. Sixteen players (average age 16.87 ± 0.34 years; body height 176.69 ± 3.21 cm; body mass 62.40 ± 2.59 kg; training experience 3.75 ± 0.44 years) performed four bouts 2-a-side, 3-a-side and 4-a-side games with three minutes active (SSGar: Running at 70% of HRmax) and passive (SSGpr) rest between bouts at two-day intervals...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339686/clinical-characteristics-and-outcomes-of-acute-coronary-syndrome-patients-with-intra-aortic-balloon-pump-inserted-in-intensive-cardiac-care-unit-of-a-tertiary-clinic
#15
Mert İlker Hayıroğlu, Yiğit Çanga, Özlem Yıldırımtürk, Emrah Bozbeyoğlu, Ayça Gümüşdağ, Ahmet Okan Uzun, Koray Kalenderoğlu, Muhammed Keskin, Göksel Çinier, Murat Acarel, Seçkin Pehlivanoğlu
OBJECTIVE: An intra-aortic balloon pump (IABP) is a mechanical support device that is used in addition to pharmacological treatment of the failing heart in intensive cardiac care unit (ICCU) patients. In the literature, there are limited data regarding the clinical characteristics and in-hospital outcomes of acute coronary syndrome patients in Turkey who had an IABP inserted during their ICCU stay. This study is an analysis of the clinical characteristics and outcomes of these acute coronary syndrome patients...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29338155/association-between-caregiver-exposure-to-toxics-during-pregnancy-and-childhood-onset-asthma-a-case-control-study
#16
Souheil Hallit, Chantal Raherison, Mirna Waked, Pascale Salameh
The aim of this study was to evaluate the associations between caregiver-reported use of medications, alcohol, cigarette and/or waterpipe (WP), and exposure to pesticides/detergents during pregnancy with childhood-onset asthma. The study design consisted of a case-control study, conducted between December 2015 and April 2016, recruited 1503 children, aged between 3-16 years old. A questionnaire assessed the sociodemographic characteristics (age, gender, education level of both parents), the family history of asthma, and other known risk factors of asthma (heating system at home, child history of recurrent otitis, humidity in the house, child went to a daycare, smoking and drinking alcohol during pregnancy, exposure to pesticides and detergents)...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29335080/-clinical-characteristics-of-refractory-mycoplasma-pneumoniae-pneumonia-in-children
#17
Jiang-Jiang Xu, Lin-Hua Shu
OBJECTIVE: To provide a basis for early diagnosis and treatment of refractory Mycoplasma pneumoniae pneumonia (RMPP) in children by comparing the clinical characteristics of RMPP and general Mycoplasma pneumoniae pneumonia (MPP). METHODS: Children with MPP hospitalized between October 2015 and December 2016 were selected as study subjects. According to the diagnostic criteria, children were divided into RMPP group (n=152) and MPP group (n=551). The differences between the two groups in the basic situation, clinical manifestations, infection parameters and myocardial enzymes were compared...
January 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29334343/breast-milk-iodine-concentrations-and-iodine-levels-of-infants-according-to-the-iodine-status-of-the-country-of-residence-a-systematic-review-and-meta-analysis
#18
Pantea Nazeri, Ali Kabir, Hosein Dalili, Parvin Mirmiran, Fereidoun Azizi
BACKGROUND: Iodine, an essential micronutrient, plays a critical role in normal growth and development, especially during the first two years of life. This systematic review and meta-analysis is among the first to evaluate breast-milk iodine concentrations and infant iodine status in countries characterized by iodine sufficiency or deficiency. METHODS: PubMed, Web of Science, Cochrane Library, Google Scholar, and other relevant databases, as well as reference lists of previous reviews, were searched for relevant studies published between 1986 and 2016...
January 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29333404/relevance-of-prognostic-index-with-%C3%AE-2-microglobulin-for-patients-with-diffuse-large-b-cell-lymphoma-in-the-rituximab-era
#19
Jihoon Kang, Shinkyo Yoon, Cheolwon Suh
Background: The International Prognostic Index (IPI) has been a useful tool for predicting the prognosis of aggressive non-Hodgkin lymphoma in the last 20 years. Herein, we aimed to develop a new prognostic model for diffuse large B-cell lymphoma (DLBCL) in the rituximab era. Methods: Between March 2004 and June 2012, patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy regimen were identified in the database of the Asan Medical Center (AMC) Lymphoma Registry...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29333403/treatment-outcomes-of-dose-attenuated-chop-chemotherapy-in-elderly-patients-with-peripheral-t-cell-lymphoma
#20
Eun-Ji Choi, Jung Yong Hong, Dok Hyun Yoon, Jihoon Kang, Chan-Sik Park, Jooryung Huh, Eun Jin Chae, Yoonse Lee, Jin-Sook Ryu, Cheolwon Suh
Background: While cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) is the most commonly used chemotherapeutic regimen for patients with peripheral T-cell lymphomas (PTCLs), elderly patients are more vulnerable to associated toxicities. We evaluated the efficacy and safety of dose-attenuated CHOP in elderly patients with PTCL. Methods: Patients with PTCL aged >70 years or 65-70-years with comorbidities were treated with dose-attenuated CHOP (cyclophosphamide: 562...
December 2017: Blood Research
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