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Lactate AND Aging

Viviane Nogueira, Jose Brito-Alves, Danilo Fontes, Larissa Oliveira, Waldecy Lucca, Yves Tourneur, Almir Wanderley, Glauber S F da Silva, Carol Leandro, João Henrique Costa-Silva
The aim of this study is to evaluate the short-term and long-term effects elicited by carotid body removal (CBR) on ventilatory function and the development of hypertension in the offspring of malnourished rats. Wistar rats were fed a normo-protein (NP, 17% casein) or low-protein (LP, 8% casein) diet during pregnancy and lactation. At 29 days of age, the animals were submitted to CBR or a sham surgery, according to the following groups: NP-cbr, LP-cbr, NP-sham, or LP-sham. In the short-term, at 30 days of age, the respiratory frequency (RF) and immunoreactivity for Fos on the retrotrapezoid nucleus (RTN; brainstem site containing CO2 sensitive neurons) after exposure to CO2 were evaluated...
September 21, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
A Sauret, M-C Andro-Garçon, J Chauvel, A Ligneul, P Dupas, C Fressange-Mazda, P Le Ruyet, A Dabadie
OBJECTIVE: The purpose of this study was to evaluate the dose-dependent effect of human milk fortifier (HMF) on the osmolality of various preterm human milks (PHMs) at different gestational and lactation stages, and with different storage and treatment conditions that are routinely used in neonatal intensive care units (NICUs). STUDY DESIGN: Twenty-four mothers who had given birth to their baby before 28 or between 29 and 31 weeks of pregnancy participated in the study after 1-2 weeks or 3-4 weeks breastfeeding after delivery...
September 18, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Shebli Atrash, Qing Zhang, Xenofon Papanikolaou, Caleb Stein, Al-Ola Abdallah, Bart Barlogie
PURPOSE: Multiple myeloma (MM) is a clonal bone marrow disease characterized by the neoplastic transformation of differentiated postgerminal B cells. It is a heterogeneous disease both at the genetic level and in terms of clinical outcome. Immunoglobulin M (IgM) MM is a rare subtype of myeloma. Similar to Waldenström macroglobulinemia (WM), patients with MM experience IgM monoclonal gammopathy; however, both diseases are distinct in terms of treatment and clinical behavior. MATERIALS AND METHODS: To shed light on the presentation of IgM MM, its prognosis, and its gene expression profiling, we identified and characterized 21 patients with IgM MM from our database...
September 2018: Journal of Global Oncology
Nina Schlossman
BACKGROUND: This article synthesizes the results of 3 cluster randomized controlled trials of dairy-containing ready-to-use supplementary foods (RUSFs) to address malnutrition in primary schools, preschools and villages in Guinea-Bissau, one of the world's poorest countries. Together, these studies document widespread malnutrition across infants, young children, adolescents, and pregnant and lactating women and point to intervention options that were not previously presented. OBJECTIVE: To combine the evidence from the United States Department of Agriculture-funded pilot studies in Guinea-Bissau on the effects of dairy protein supplementation to gain a broader perspective on the role of dairy containing RUSFs in various age-groups, the importance of the mother-child dyad and family food dynamics for infant and child growth...
September 2018: Food and Nutrition Bulletin
Miłosz Czuba, Olga Fidos-Czuba, Kamila Płoszczyca, Adam Zając, Józef Langfort
The aim of the study was to compare the effect of intermittent hypoxic training (IHT) and the live high, train low strategy on aerobic capacity and sports performance in off-road cyclists in normoxia. Thirty off-road cyclists were randomized to three groups and subjected to 4-week training routines. The participants from the first experimental group were exposed to normobaric hypoxia conditions (FiO2 = 16.3%) at rest and during sleep (G-LH-TL; n=10; age: 20.5 ± 2.9 years; body height 1.81 ± 0.04 m; body mass: 69...
March 2018: Biology of Sport
V C Keil, L Eichhorn, H J M M Mutsaerts, F Träber, W Block, B Mädler, K van de Ven, J C W Siero, B J MacIntosh, J Petr, R Fimmers, H H Schild, E Hattingen
BACKGROUND AND PURPOSE: Experienced freedivers can endure prolonged breath-holds despite severe hypoxemia and are therefore ideal subjects to study apnea-induced cerebrovascular reactivity. This multiparametric study investigated CBF, the spatial coefficient of variation as a correlate of arterial transit time and brain metabolism, dynamics during prolonged apnea. MATERIALS AND METHODS: Fifteen male freedivers (age range, 20-64 years; cumulative previous prolonged breath-holds >2 minutes and 30 seconds: 4-79,200) underwent repetitive 3T pseudocontinuous arterial spin-labeling and 31 P-/1 H-MR spectroscopy before, during, and after a 5-minute breath-hold (split into early and late phases) and gave temporally matching venous blood gas samples...
September 20, 2018: AJNR. American Journal of Neuroradiology
A Claire Watkins, Nathan L Maassel, Mehrdad Ghoreishi, Murtaza Y Dawood, Si M Pham, Zachary N Kon, Bradley S Taylor, Bartley P Griffith, James S Gammie
BACKGROUND: Cardiac surgery for structural heart disease has poor outcomes in the presence of cardiogenic shock or advanced heart failure. We applied venoarterial extracorporeal membrane oxygenation (ECMO) to restore end-organ function and resuscitate patients before high-risk cardiac operation. METHODS: Twelve patients with cardiogenic shock and end-organ failure were evaluated for cardiac surgery. The average Society of Thoracic Surgeons (STS) mortality risk was 24% (±13)...
September 17, 2018: Annals of Thoracic Surgery
Parminder S Chaggar, Ewan J McKay, Philip Foden, Simon G Williams, Jim Barnard, Nizar Yonan, Rajamiyer Venkateswaran, Steven M Shaw
AIM: We describe the characteristics and outcomes of cardiogenic shock (CS) admissions to a UK transplant unit, which is previously unreported. PATIENTS & METHODS: Fifty-nine unselected, consecutive patients over a 38-month period in CS (INTERMACS ≤2) and potentially eligible for transplant were retrospectively reviewed. RESULTS: Patients were predominantly male (76.3%), young (mean age 42.2 years) and with severe end-organ dysfunction (acute liver/kidney injury 83%, mean lactate 3...
September 20, 2018: Future Cardiology
Nina Gertsvolf, Jodie K Votava-Smith, Rafael Ceschin, Sylvia Del Castillo, Vince Lee, Hollie A Lai, Stefan Bluml, Lisa Paquette, Ashok Panigrahy
Complex congenital heart disease (CHD) is associated with neurodevelopmental impairment, the mechanism of which is unknown. Cerebral cortical dysmaturation in CHD is linked to white matter abnormalities, including developmental vulnerability of the subplate, in relation to oxygen delivery and metabolism deficits. In this study, we report associations between subcortical morphology and white matter metabolism in neonates with CHD using quantitative magnetic resonance imaging (MRI) and spectroscopy (MRS). Multi-modal brain imaging was performed in three groups of neonates close to term-equivalent age: (1) term CHD (n = 56); (2) preterm CHD (n = 37) and (3) preterm control group (n = 22)...
September 19, 2018: Scientific Reports
Atul Malhotra, Margie Castillo-Melendez, Beth J Allison, Amy Elizabeth Sutherland, Ilias Nitsos, Yen Pham, Anna Alves de Alencar Rocha, Michael C Fahey, Graeme R Polglase, Graham Jenkin, Suzanne Lee Miller
Fetal growth restriction (FGR) and prematurity are associated with risk of brain injury and long-term neurological deficits. FGR infants born preterm are commonly exposed to mechanical ventilation, but it is not known whether ventilation differentially induces brain pathology in FGR infants, compared to appropriate for gestational age (AGA) infants. We investigated markers of neuropathology in preterm FGR lambs, compared with AGA lambs, delivered by caesarean birth and ventilated under standard neonatal conditions for 24 hours...
September 19, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
E Tomaszewska, P Dobrowolski, S Muszyński, M Kwiecień, K Kasperek, S Knaga, A Tomczyk-Warunek, S Kowalik, G Jeżewska-Witkowska, E R Grela
1. The aim of study was to investigate whether the impact of the yeast Saccharomyces cerevisiae on the histological structure of the intestine, innervation of the small intestine wall, and basal biochemical serum parameters in Japanese quail was sex dependent. 2. One-day-old healthy male and female Japanese quail were fed either a basal diet containing no yeast (control group) or the basal diet plus 1.5% (15 g/kg of diet) of yeast (S. cerevisiae inactivated by drying). Samples from the duodenum and jejunum were taken from each bird at the age of 42 days...
September 19, 2018: British Poultry Science
Young Ah Lee, Sun Wook Cho, Ho Kyung Sung, Kyungsik Kim, Young Shin Song, Sin Je Moon, Jung Won Oh, Dal Lae Ju, Sooyeon Choi, Sang Hoon Song, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Sue K Park, Jong Kwan Jun, June Key Chung
BACKGROUND: Iodine is an intrinsic element of thyroid hormone, which is essential for childhood growth and development. The Ideal Breast Milk (IBM) cohort study aims to evaluate the effects of maternal iodine status during pregnancy and lactation on maternal thyroid function, offspring growth and development, and offspring thyroid function. METHODS: The IBM cohort study recruited pregnant women from Seoul National University Hospital between June 2016 and August 2017, followed by enrollment of their offspring after delivery...
September 2018: Endocrinology and Metabolism
Pedro Américo D Dias, Beatriz Cano-Huertes, Alejandro Coyohua-Fuentes, David Roberto Chavira-Ramírez, Domingo Canales-Espinosa, Ariadna Rangel-Negrín
OBJECTIVES: Lactation is a costly reproductive state for females, as it may entail decreased body condition, increased morbidity, and increased mortality risk. To offset these costs, mothers should allocate investment in infant care as a function of their physical condition. Here, we assessed the relationship between maternal condition and maternal investment in wild mantled howler monkeys (Alouatta palliata) to determine: (1) whether maternal physical condition varied as a function of food availability, activity levels and feeding effort throughout lactation; (2) whether maternal investment was affected by maternal condition and offspring age...
September 2018: American Journal of Physical Anthropology
Ram Kumar Manthari, Chiranjeevi Tikka, Mohammad Mehdi Ommati, Ruiyan Niu, Zilong Sun, Jinming Wang, Jianhai Zhang, Jundong Wang
For the past decade, there has been an increased concern about the health risks from arsenic (As) exposure, because of its neurotoxic effects on the developing brain. The exact mechanism underlying As-induced neurotoxicity during sensitive periods of brain development remains unclear, especially the role of blood-brain barrier's (BBB) tight junction (TJ) proteins during As-induced neurotoxicity. Here, we highlight the involvement of TJ proteins in As-induced autophagy in cerebral cortex and hippocampus during developmental periods [postnatal day (PND) 21, 28, 35 and 42]...
September 17, 2018: Archives of Toxicology
Wei Gao, Qiyong Zhu, Haibin Ni, Jialiu Zhang, Dandan Zhou, Liping Yin, Feng Zhang, Hao Chen, Beibei Zhang, Wei Li
OBJECTIVE: To investigate the value of the difference between peripheral arterial and venous blood gas analysis for the prognosis of patients with septic shock after resuscitation. METHODS: Patients with septic shock aged 18 to 80 years admitted to intensive care unit (ICU) of Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine from May 2016 to December 2017 were enrolled. The peripheral arterial blood and peripheral venous blood gas analysis were measured simultaneously after the early 6 hours resuscitation, including pH, partial pressure of oxygen (PO2 ), partial pressure of carbon dioxide (PCO2 ), base excess (BE), bicarbonate (HCO3 - ) and lactate (Lac) level, and the difference values between peripheral arterial and venous blood were calculated...
August 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
D S Beggs, E C Jongman, P E Hemsworth, A D Fisher
In large Australian pasture-based dairy herds, it is common for the time taken to milk a herd of cows to be up to 4 h. Cows are collected from the paddock as a group, wait in turn in the dairy yard to be milked, and then return individually to the paddock or feed pad immediately after leaving the milking parlor. In such herds, we previously found a consistent milking order, resulting in some cows being regularly away from pasture for several hours per day more than others. Increased time away from pasture may affect the time budgets of cows because of decreased opportunity for grazing or lying down...
September 12, 2018: Journal of Dairy Science
Sunil Sazawal, Usha Dhingra, Pratibha Dhingra, Arup Dutta, Saikat Deb, Jitendra Kumar, Prabhabati Devi, Ashish Prakash
BACKGROUND: Biofortification of staple food crops with zinc (Zn) can be one of the cost-effective and sustainable strategies to combat zinc deficiency and prevent morbidity among the target population. Agronomic approaches such as application of Zn fertilizers to soil and/or foliar spray seem to be a practical tool for Zn biofortification of wheat. However, there is a need to evaluate its efficacy from randomized controlled trials. This study aimed to evaluate the efficacy of zinc biofortified wheat flour on zinc status and its impact on morbidity among children aged 4-6 years and non-pregnant non lactating woman of child bearing age (WCBA) in Delhi, India...
September 15, 2018: Nutrition Journal
Zeynep Ozdemir, Bunyamin Tras, Kamil Uney, Hatice Eser Faki, Tugba Melike Besoluk
This study was conducted to determine the passage ratio of amoxicillin into milk and its pharmacokinetics in milk and plasma after intramuscular administration. Five healthy dairy cows (Holstein, weighing 450-500 kg, aged 2-4 years) were used in this study. They received single intramuscular amoxicillin at a dose of 14 mg/kg body weight. Blood and milk samples were collected prior to drug administration (0); after 15, 30, 45, 60, and 90 min; and 2, 3, 4, 6, 8, 10, and 12 hr after administration. The plasma and milk concentrations of amoxicillin were determined using high-performance liquid chromatography with ultraviolet detection...
September 15, 2018: Journal of Veterinary Pharmacology and Therapeutics
Michele L Esposito, Kevin J Morine, Shiva K Annamalai, Ryan O'Kelly, Nima Aghili, Robert Pedicini, Catalina Breton, Andrew Mullin, Anas Hamadeh, Michael S Kiernan, David DeNofrio, Navin K Kapur
Hemolysis is a potential limitation of percutaneously delivered left-sided mechanical circulatory support pumps, including trans valvular micro-axial flow pumps (TVP). Hemolytic biomarkers among durable left ventricular assist devices include lactate dehydrogenase (LDH) >2.5 times the upper limit of normal (ULN) and plasma-free hemoglobin (pf-Hb) >20 mg/dL. We examined the predictive value of these markers among patients with cardiogenic shock (CS) receiving a TVP. We retrospectively studied records of 116 consecutive patients receiving an Impella TVP at our institution between 2012 and 2017 for CS...
September 14, 2018: Artificial Organs
Richard T Waldron, Aurelia Lugea, Aiste Gulla, Stephen J Pandol
Acute pancreatitis (AP) is a painful and potentially life-threatening disorder with the potential for therapeutic interventions. Biomarkers that characterize cases by severity and pathogenic mechanisms involved are not yet available but needed for the implementation of rational therapies. Here, we used shotgun proteomics to obtain information from plasma samples about local and systemic pathologies taking place during cases of alcoholic AP. Plasma was obtained at Kaunas University of Medicine Hospital (Lithuania) from 12 AP patients of alcohol related etiology (median age of 40) within 24 h of presentation, and 12 age-matched, healthy controls...
2018: Frontiers in Physiology
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