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REVIEW
Joshua M Riley, James J Fradin, Douglas H Russ, Eric D Warner, Yevgeniy Brailovsky, Indranee Rajapreyar
Pulmonary hypertension (PH) caused by left heart disease, also known as post-capillary PH, is the most common etiology of PH. Left heart disease due to systolic dysfunction or heart failure with preserved ejection fraction, valvular heart disease, and left atrial myopathy due to atrial fibrillation are causes of post-capillary PH. Elevated left-sided filling pressures cause pulmonary venous congestion due to backward transmission of pressures and post-capillary PH. In advanced left-sided heart disease or valvular heart disease, chronic uncontrolled venous congestion may lead to remodeling of the pulmonary arterial system, causing combined pre-capillary and post-capillary PH...
January 22, 2024: Journal of Clinical Medicine
#22
JOURNAL ARTICLE
Valerie J Block, Kanishka Koshal, Jaeleene Wijangco, Nicolette Miller, Narender Sara, Kyra Henderson, Jennifer Reihm, Arpita Gopal, Sonam D Mohan, Jeffrey M Gelfand, Chu-Yueh Guo, Lauren Oommen, Alyssa Nylander, James A Rowson, Ethan Brown, Stephen Sanders, Katherine Rankin, Courtney R Lyles, Ida Sim, Riley Bove
BACKGROUND: Falls are common in people with multiple sclerosis (MS), causing injuries, fear of falling, and loss of independence. Although targeted interventions (physical therapy) can help, patients underreport and clinicians undertreat this issue. Patient-generated data, combined with clinical data, can support the prediction of falls and lead to timely intervention (including referral to specialized physical therapy). To be actionable, such data must be efficiently delivered to clinicians, with care customized to the patient's specific context...
January 11, 2024: JMIR Human Factors
#23
JOURNAL ARTICLE
Oliver Eales, Michael J Plank, Benjamin J Cowling, Benjamin P Howden, Adam J Kucharski, Sheena G Sullivan, Katelijn Vandemaele, Cecile Viboud, Steven Riley, James M McCaw, Freya M Shearer
To support the ongoing management of viral respiratory diseases while transitioning out of the acute phase of the COVID-19 pandemic, many countries are moving toward an integrated model of surveillance for SARS-CoV-2, influenza virus, and other respiratory pathogens. Although many surveillance approaches catalyzed by the COVID-19 pandemic provide novel epidemiologic insight, continuing them as implemented during the pandemic is unlikely to be feasible for nonemergency surveillance, and many have already been scaled back...
January 8, 2024: Emerging Infectious Diseases
#24
JOURNAL ARTICLE
Jacqueline MacDonald Gibson, April Desclos, James Harrington, Shawn P McElmurry, Riley Mulhern
Multiple recent studies have found elevated lead (Pb) concentrations in tap water in U.S. homes relying on unregulated private wells. The main Pb source is dissolution from household plumbing, fixtures, and well components. Here, we leverage a natural experiment and citizen science approach to evaluate how extending community water service to an environmental justice community relying on private wells affects Pb in household water. We analyzed Pb in 260 first-draw kitchen tap water samples collected by individual homeowners over a 5-month period in residences that did and did not connect to the community system...
January 8, 2024: Environmental Science & Technology
#25
JOURNAL ARTICLE
Nathan Riley, Helga Förster, James Adaskaveg
Isolates of the citrus brown rot pathogens P. citrophthora and P. syringae from the Inland Empire (IE) and Ventura Co. (VE) regions of southern California were evaluated for their sensitivity to ethaboxam, fluopicolide, mandipropamid, and oxathiapiprolin, and the previously published baselines that were generated for Central Valley (CV) isolates of California were expanded. Fungicides were generally more toxic to CV isolates of both species for all four fungicides. Specific differences were found in the toxicity of ethaboxam to P...
January 3, 2024: Plant Disease
#26
Stella Victorelli, Hanna Salmonowicz, James Chapman, Helene Martini, Maria Grazia Vizioli, Joel S Riley, Catherine Cloix, Ella Hall-Younger, Jair Machado Espindola-Netto, Diana Jurk, Anthony B Lagnado, Lilian Sales Gomez, Joshua N Farr, Dominik Saul, Rebecca Reed, George Kelly, Madeline Eppard, Laura C Greaves, Zhixun Dou, Nicholas Pirius, Karolina Szczepanowska, Rebecca A Porritt, Huijie Huang, Timothy Y Huang, Derek A Mann, Claudio Akio Masuda, Sundeep Khosla, Haiming Dai, Scott H Kaufmann, Emmanouil Zacharioudakis, Evripidis Gavathiotis, Nathan K LeBrasseur, Xue Lei, Alva G Sainz, Viktor I Korolchuk, Peter D Adams, Gerald S Shadel, Stephen W G Tait, João F Passos
No abstract text is available yet for this article.
January 2, 2024: Nature
#27
Sarabeth M Mathis, Alexander E Webber, Tomás M León, Erin L Murray, Monica Sun, Lauren A White, Logan C Brooks, Alden Green, Addison J Hu, Daniel J McDonald, Roni Rosenfeld, Dmitry Shemetov, Ryan J Tibshirani, Sasikiran Kandula, Sen Pei, Jeffrey Shaman, Rami Yaari, Teresa K Yamana, Pulak Agarwal, Srikar Balusu, Gautham Gururajan, Harshavardhan Kamarthi, B Aditya Prakash, Rishi Raman, Alexander Rodríguez, Zhiyuan Zhao, Akilan Meiyappan, Shalina Omar, Prasith Baccam, Heidi L Gurung, Steve A Stage, Brad T Suchoski, Marco Ajelli, Allisandra G Kummer, Maria Litvinova, Paulo C Ventura, Spencer Wadsworth, Jarad Niemi, Erica Carcelen, Alison L Hill, Sung-Mok Jung, Joseph C Lemaitre, Justin Lessler, Sara L Loo, Clifton D McKee, Koji Sato, Claire Smith, Shaun Truelove, Thomas McAndrew, Wenxuan Ye, Nikos Bosse, William S Hlavacek, Yen Ting Lin, Abhishek Mallela, Ye Chen, Shelby M Lamm, Jaechoul Lee, Richard G Posner, Amanda C Perofsky, Cécile Viboud, Leonardo Clemente, Fred Lu, Austin G Meyer, Mauricio Santillana, Matteo Chinazzi, Jessica T Davis, Kunpeng Mu, Ana Pastore Y Piontti, Alessandro Vespignani, Xinyue Xiong, Michal Ben-Nun, Pete Riley, James Turtle, Chis Hulme-Lowe, Shakeel Jessa, V P Nagraj, Stephen D Turner, Desiree Williams, Avranil Basu, John M Drake, Spencer J Fox, Graham C Gibson, Ehsan Suez, Edward W Thommes, Monica G Cojocaru, Estee Y Cramer, Aaron Gerding, Ariane Stark, Evan L Ray, Nicholas G Reich, Li Shandross, Nutcha Wattanachit, Yijin Wang, Martha W Zorn, Majd Al Aawar, Ajitesh Srivastava, Lauren A Meyers, Aniruddha Adiga, Benjamin Hurt, Gursharn Kaur, Bryan L Lewis, Madhav Marathe, Srinivasan Venkatramanan, Patrick Butler, Andrew Farabow, Nikhil Muralidhar, Naren Ramakrishnan, Carrie Reed, Matthew Biggerstaff, Rebecca K Borchering
Accurate forecasts can enable more effective public health responses during seasonal influenza epidemics. Forecasting teams were asked to provide national and jurisdiction-specific probabilistic predictions of weekly confirmed influenza hospital admissions for one through four weeks ahead for the 2021-22 and 2022-23 influenza seasons. Across both seasons, 26 teams submitted forecasts, with the submitting teams varying between seasons. Forecast skill was evaluated using the Weighted Interval Score (WIS), relative WIS, and coverage...
December 11, 2023: medRxiv
#28
JOURNAL ARTICLE
Rohan Mehra, Benjamin James Patterson, Peter Andrew Riley, Timothy David Planche, Aodhan Sean Breathnach
BACKGROUND: Mandatory mask-wearing policies were one of several measures employed to reduce hospital-acquired SARS-CoV-2 infection throughout the pandemic. Many nations have removed healthcare mask mandates, but with the ongoing risk of new SARS-CoV-2 variants or epidemics of other respiratory viruses, it is important to demonstrate the impact of this policy reversal. METHODS: We analysed SARS-CoV-2 infections in a large teaching hospital over 40 weeks in 2022 using a controlled interrupted time series design...
December 21, 2023: Journal of Hospital Infection
#29
JOURNAL ARTICLE
Yuqi Zhou, Julie Jadlowsky, Caitlin Baiduc, Alex W Klattenhoff, Zhilin Chen, Alan D Bennett, Nicholas J Pumphrey, Bent K Jakobsen, James L Riley
Engineered T cells hold great promise to become part of an effective HIV cure strategy, but it is currently unclear how best to redirect T cells to target HIV. To gain insight, we generated engineered T cells using lentiviral vectors encoding one of three distinct HIV-specific T cell receptors (TCRs) or a previously optimized HIV-targeting chimeric antigen receptor (CAR) and compared their functional capabilities. All engineered T cells had robust, antigen-specific polyfunctional cytokine profiles when mixed with artificial antigen-presenting cells...
December 15, 2023: PLoS Pathogens
#30
JOURNAL ARTICLE
Nathan Riley, Helga Forster, James E Adaskaveg
Phytophthora citrophthora and P. syringae are currently the primary causal organisms of brown rot of citrus fruits in California. To possibly find an explanation for the prevalence of the previously minor species P. syringae, we determined the population structures of both pathogens using next-generation sequencing and population genomics analyses. Whole genome sequencing and aligning with newly assembled reference genomes identified 972,266 variants in 132 isolates of P. citrophthora and 422,208 variants in 154 isolates (including 24 from non-citrus tree crops) of P...
November 21, 2023: Phytopathology
#31
JOURNAL ARTICLE
Joey Junarta, Sebastian Rodriguez, Waqas Ullah, Muhammad U Siddiqui, Joshua M Riley, Anjani Patel, Parker O'Neill, Sean J Dikdan, James J Fradin, Jake L Rosen, Daniel R Frisch
BACKGROUND: The optimal power and duration settings for radiofrequency (RF) atrial fibrillation (AF) ablation to improve efficacy and safety is unclear. We compared low-power long-duration (LPLD), high-power short-duration (HPSD), and very HPSD (vHPSD) RF settings for AF ablation. METHODS: This network meta-analysis (NMA) was structured according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Medline, Scopus and Cochrane Central Register of Controlled Trials were systematically searched to identify relevant studies...
November 16, 2023: Pacing and Clinical Electrophysiology: PACE
#32
JOURNAL ARTICLE
James P Allen, Kathryn B Garber, Riley Perszyk, Cara T Khayat, Steven A Kell, Maki Kaneko, Catherine Quindipan, Sulagna Saitta, Roger L Ladda, Stacy Hewson, Michal Inbar-Feigenberg, Chitra Prasad, Asuri N Prasad, Leah Olewiler, Weiyi Mu, Liana S Rosenthal, Marcello Scala, Pasquale Striano, Federico Zara, Tyler W McCullock, Robin-Tobias Jauss, Johannes R Lemke, David M MacLean, Cheng Zhu, Hongjie Yuan, Scott J Myers, Stephen F Traynelis
GRID1 and GRID2 encode the enigmatic GluD1 and GluD2 proteins, which form tetrameric receptors that play important roles in synapse organization and development of the central nervous system. Variation in these genes has been implicated in neurodevelopmental phenotypes. We evaluated GRID1 and GRID2 human variants from the literature, ClinVar, and clinical laboratories and found that many of these variants reside in intolerant domains, including the amino terminal domain of both GRID1 and GRID2. Other conserved regions, such as the M3 transmembrane domain, show different intolerance between GRID1 and GRID2...
November 7, 2023: Human Molecular Genetics
#33
JOURNAL ARTICLE
Axel Hochkirch, Melanie Bilz, Catarina C Ferreira, Anja Danielczak, David Allen, Ana Nieto, Carlo Rondinini, Kate Harding, Craig Hilton-Taylor, Caroline M Pollock, Mary Seddon, Jean-Christophe Vié, Keith N A Alexander, Emily Beech, Manuel Biscoito, Yoan Braud, Ian J Burfield, Filippo Maria Buzzetti, Marta Cálix, Kent E Carpenter, Ning Labbish Chao, Dragan Chobanov, Maarten J M Christenhusz, Bruce B Collette, Mia T Comeros-Raynal, Neil Cox, Matthew Craig, Annabelle Cuttelod, William R T Darwall, Benoit Dodelin, Nicholas K Dulvy, Eve Englefield, Michael F Fay, Nicholas Fettes, Jörg Freyhof, Silvia García, Mariana García Criado, Michael Harvey, Nick Hodgetts, Christina Ieronymidou, Vincent J Kalkman, Shelagh P Kell, James Kemp, Sonia Khela, Richard V Lansdown, Julia M Lawson, Danna J Leaman, Joana Magos Brehm, Nigel Maxted, Rebecca M Miller, Eike Neubert, Baudewijn Odé, David Pollard, Riley Pollom, Rob Pople, Juan José Presa Asensio, Gina M Ralph, Hassan Rankou, Malin Rivers, Stuart P M Roberts, Barry Russell, Alexander Sennikov, Fabien Soldati, Anna Staneva, Emilie Stump, Andy Symes, Dmitry Telnov, Helen Temple, Andrew Terry, Anastasiya Timoshyna, Chris van Swaay, Henry Väre, Rachel H L Walls, Luc Willemse, Brett Wilson, Jemma Window, Emma G E Wright, Thomas Zuna-Kratky
Biodiversity loss is a major global challenge and minimizing extinction rates is the goal of several multilateral environmental agreements. Policy decisions require comprehensive, spatially explicit information on species' distributions and threats. We present an analysis of the conservation status of 14,669 European terrestrial, freshwater and marine species (ca. 10% of the continental fauna and flora), including all vertebrates and selected groups of invertebrates and plants. Our results reveal that 19% of European species are threatened with extinction, with higher extinction risks for plants (27%) and invertebrates (24%) compared to vertebrates (18%)...
2023: PloS One
#34
JOURNAL ARTICLE
Kelly Fedoruk, James Xie, Ellen Wang, Cedar Fowler, Edward Riley, Brendan Carvalho
BACKGROUND: Monitoring complications associated with medical procedures requires reliable and accurate record keeping. Nudge reminders executed by way of electronic medical record (EMR) alerts influence clinician behaviour. We hypothesised that the introduction of an EMR nudge would improve documentation of replaced neuraxial blocks by obstetric anaesthesiologists at our institution. METHODS: We developed an EMR nudge that would alert the physician to a replaced neuraxial block if two or more neuraxial procedure notes in a single patient encounter were detected...
October 2023: BMJ Open Quality
#35
JOURNAL ARTICLE
Riley Steel, Michelle Hamed, Josefine T Haugom, Trang Ho, Nathaniel Kenner, Joanna Malfavon-Borja, Scott Morgans, Savannah A Salek, Allen Seylani, James K Jancovich
Ranaviruses are large, dsDNA viruses that have significant ecological and economic impact on cold-blooded vertebrates. However, our understanding of the viral proteins and subsequent host immune response(s) that impact susceptibility to infection and disease is not clear. The ranavirus Ambystoma tigrinum virus (ATV), originally isolated from the Sonoran tiger salamander (Ambystoma mavortium stebbinsi), is highly pathogenic at low doses of ATV at all tiger salamander life stages and this model has been used to explore the host-pathogen interactions of ATV infection...
October 18, 2023: Virology
#36
JOURNAL ARTICLE
Valentyna Yasinska, Cristina Gómez, Johan Kolmert, Magnus Ericsson, Anton Pohanka, Anna James, Lars I Andersson, Maria Sparreman-Mikus, Ana R Sousa, John H Riley, Stewart Bates, Per S Bakke, Nazanin Zounemat Kermani, Massimo Caruso, Pascal Chanez, Stephen J Fowler, Thomas Geiser, Peter H Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E Shaw, Richard G Knowles, Barbro Dahlén, Anke-Hilse Maitland-van der Zee, Peter J Sterk, Ratko Djukanovic, Ian M Adcock, Kian Fan Chung, Craig E Wheelock, Sven-Erik Dahlén, Eva Wikström Jonsson
RATIONALE: Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not previously been described in detail. The objective of the present study was to measure urinary concentrations of EAAS in relation to exogenous corticosteroid exposure. METHODS: Urine collected at baseline in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcomes) study of severe adult asthmatics (SA, n=408) was analysed by quantitative mass spectrometry...
September 2023: ERJ Open Research
#37
JOURNAL ARTICLE
James Riley, Will Mason-Wilkes
Citizen science is often celebrated. We interrogate this position through exploration of socio-technoscientific phenomena that mirror citizen science yet are disaligned with its ideals. We term this 'Dark Citizen Science'. We identify five conceptual dimensions of citizen science - purpose, process, perceptibility, power and public effect . Dark citizen science mirrors traditional citizen science in purpose and process but diverges in perceptibility, power and public effect . We compare two Internet-based categorisation processes, Citizen Science project Galaxy Zoo and Dark Citizen Science project Google's reCAPTCHA...
October 20, 2023: Public Understanding of Science
#38
JOURNAL ARTICLE
Jonathon W Senefeld, Ellen K Gorman, Patrick W Johnson, M Erin Moir, Stephen A Klassen, Rickey E Carter, Nigel S Paneth, David J Sullivan, Olaf H Morkeberg, R Scott Wright, DeLisa Fairweather, Katelyn A Bruno, Shmuel Shoham, Evan M Bloch, Daniele Focosi, Jeffrey P Henderson, Justin E Juskewitch, Liise-Anne Pirofski, Brenda J Grossman, Aaron A R Tobian, Massimo Franchini, Ravindra Ganesh, Ryan T Hurt, Neil E Kay, Sameer A Parikh, Sarah E Baker, Zachary A Buchholtz, Matthew R Buras, Andrew J Clayburn, Joshua J Dennis, Juan C Diaz Soto, Vitaly Herasevich, Allan M Klompas, Katie L Kunze, Kathryn F Larson, John R Mills, Riley J Regimbal, Juan G Ripoll, Matthew A Sexton, John R A Shepherd, James R Stubbs, Elitza S Theel, Camille M van Buskirk, Noud van Helmond, Matthew N P Vogt, Emily R Whelan, Chad C Wiggins, Jeffrey L Winters, Arturo Casadevall, Michael J Joyner
OBJECTIVE: To examine the association of COVID-19 convalescent plasma transfusion with mortality and the differences between subgroups in hospitalized patients with COVID-19. PATIENTS AND METHODS: On October 26, 2022, a systematic search was performed for clinical studies of COVID-19 convalescent plasma in the literature from January 1, 2020, to October 26, 2022. Randomized clinical trials and matched cohort studies investigating COVID-19 convalescent plasma transfusion compared with standard of care treatment or placebo among hospitalized patients with confirmed COVID-19 were included...
October 2023: Mayo Clinic Proceedings. Innovations, Quality & Outcomes
#39
JOURNAL ARTICLE
Max S Riley, James Etheridge, Vanessa Palter, Herbert Zeh, Teodor Grantcharov, Zoey Kaelberer, Yves Sonnay, Douglas S Smink, Mary E Brindle, George Molina
BACKGROUND: Large-scale evaluation of surgical safety checklist performance has been limited by the need for direct observation. The OR Black Box is a multi-channel surgical data capture platform that may allow for the holistic evaluation of checklist performance at scale. STUDY DESIGN: In this retrospective cohort study, data from 7 North American academic medical centers using the OR Black Box were collected between August 2020 and January 2022. All cases captured during this period were analyzed...
October 16, 2023: Journal of the American College of Surgeons
#40
JOURNAL ARTICLE
Simon Conroy, Sally Brailsford, Christopher Burton, Tracey England, Jagruti Lalseta, Graham Martin, Suzanne Mason, Laia Maynou-Pujolras, Kay Phelps, Louise Preston, Emma Regen, Peter Riley, Andrew Street, James van Oppen
BACKGROUND: We aimed to understand urgent and emergency care pathways for older people and develop a decision support tool using a mixed methods study design. OBJECTIVE(S), STUDY DESIGN, SETTINGS AND PARTICIPANTS: Work package 1 identified best practice through a review of reviews, patient, carer and professional interviews. Work package 2 involved qualitative case studies of selected urgent and emergency care pathways in the Yorkshire and Humber region. Work package 3 analysed linked databases describing urgent and emergency care pathways identifying patient, provider and pathway factors that explain differences in outcomes and costs...
September 2023: Health Soc Care Deliv Res
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