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James Riley

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https://www.readbyqxmd.com/read/28160251/erratum-to-pediatric-emergency-medicine-point-of-care-ultrasound-summary-of-the-evidence
#1
Jennifer R Marin, Alyssa M Abo, Alexander C Arroyo, Stephanie J Doniger, Jason W Fischer, Rachel Rempell, Brandi Gary, James F Holmes, David O Kessler, Samuel H F Lam, Marla C Levine, Jason A Levy, Alice Murray, Lorraine Ng, Vicki E Noble, Daniela Ramirez-Schrempp, David C Riley, Turandot Saul, Vaishali Shah, Adam B Sivitz, Ee Tein Tay, David Teng, Lindsey Chaudoin, James W Tsung, Rebecca L Vieira, Yaffa M Vitberg, Resa E Lewiss
No abstract text is available yet for this article.
December 2017: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/28117148/generation-of-human-islet-specific-regulatory-t-cells-by-tcr-gene-transfer
#2
Caroline M Hull, Lauren E Nickolay, Megan Estorninho, Max W Richardson, James L Riley, Mark Peakman, John Maher, Timothy I M Tree
Based on the success in animal models of type 1 diabetes (T1D), clinical trials of adoptive regulatory T cell (Treg) therapy are underway using ex vivo expanded polyclonal Tregs. However, pre-clinical data also demonstrate that islet-specific Tregs are more potent than polyclonal Tregs at reversing T1D. Translation of this approach into man will require methods to generate large populations of islet-specific Tregs which, to date, has proved to be a major hurdle. Here we demonstrate the feasibility of lentiviral-mediated T cell receptor (TCR) gene transfer to confer antigen specificity on polyclonal human Tregs...
January 20, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28090753/inferring-infection-hazard-in-wildlife-populations-by-linking-data-across-individual-and-population-scales
#3
Kim M Pepin, Shannon L Kay, Ben D Golas, Susan S Shriner, Amy T Gilbert, Ryan S Miller, Andrea L Graham, Steven Riley, Paul C Cross, Michael D Samuel, Mevin B Hooten, Jennifer A Hoeting, James O Lloyd-Smith, Colleen T Webb, Michael G Buhnerkempe
Our ability to infer unobservable disease-dynamic processes such as force of infection (infection hazard for susceptible hosts) has transformed our understanding of disease transmission mechanisms and capacity to predict disease dynamics. Conventional methods for inferring FOI estimate a time-averaged value and are based on population-level processes. Because many pathogens exhibit epidemic cycling and FOI is the result of processes acting across the scales of individuals and populations, a flexible framework that extends to epidemic dynamics and links within-host processes to FOI is needed...
January 16, 2017: Ecology Letters
https://www.readbyqxmd.com/read/28087371/use-of-the-heart-pathway-with-high-sensitivity-cardiac-troponins-a-secondary-analysis
#4
Simon A Mahler, Jason P Stopyra, Fred S Apple, Robert F Riley, Gregory B Russell, Brian C Hiestand, James W Hoekstra, Cedric W Lefebvre, Bret A Nicks, David M Cline, Kim L Askew, David M Herrington, Gregory L Burke, Chadwick D Miller
OBJECTIVES: The HEART Pathway combines a decision aid and serial contemporary cardiac troponin I (cTnI) measures to achieve >99% sensitivity for major adverse cardiac events (MACE) at 30days and early discharge rates >20%. However, the impact of integrating high-sensitivity troponin (hs-cTn) measures into the HEART Pathway has yet to be determined. In this analysis we compare test characteristics of the HEART Pathway using hs-cTnI, hs-cTnT, or cTnI. DESIGN & METHODS: A secondary analysis of participants enrolled in the HEART Pathway RCT was conducted...
January 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/27970339/tct-16-patient-and-procedural-characteristics-and-in-hospital-outcomes-associated-with-the-use-of-retrograde-recanalization-techniques-for-chronic-total-occlusion-pci-a-report-from-the-open-cto-registry
#5
Sanjog Kalra, James Sapontis, Robert Riley, Mohammed Qintar, Philip Jones, Ajay Kirtane, Manish Parikh, Jeffrey Moses, Ziad Ali, William Lombardi, William Nicholson, J Aaron Grantham, Dimitri Karmpaliotis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969624/tct-282-risk-factors-associated-with-adverse-events-during-chronic-total-occlusion-percutaneous-coronary-interventions-a-sub-analysis-of-the-open-cto-study
#6
Robert Riley, James Sapontis, Philip Jones, Ajay Kirtane, Robert Yeh, Dimitri Karmpaliotis, J Aaron Grantham, William Lombardi, Emmanouil Brilakis, James McCabe
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27917481/comprehensive-cellular-resolution-atlas-of-the-adult-human-brain
#7
Song-Lin Ding, Joshua J Royall, Susan M Sunkin, Lydia Ng, Benjamin A C Facer, Phil Lesnar, Angie Guillozet-Bongaarts, Bergen McMurray, Aaron Szafer, Tim A Dolbeare, Allison Stevens, Lee Tirrell, Thomas Benner, Shiella Caldejon, Rachel A Dalley, Nick Dee, Christopher Lau, Julie Nyhus, Melissa Reding, Zackery L Riley, David Sandman, Elaine Shen, Andre van der Kouwe, Ani Varjabedian, Michelle Write, Lilla Zollei, Chinh Dang, James A Knowles, Christof Koch, John W Phillips, Nenad Sestan, Paul Wohnoutka, H Ronald Zielke, John G Hohmann, Allan R Jones, Amy Bernard, Michael J Hawrylycz, Patrick R Hof, Bruce Fischl, Ed S LeinReference
No abstract text is available yet for this article.
February 1, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27887864/optimization-of-cgmp-purification-and-expansion-of-umbilical-cord-blood-derived-t-regulatory-cells-in-support-of-first-in-human-clinical-trials
#8
David H McKenna, Darin Sumstad, Diane M Kadidlo, Bjorn Batdorf, Colin J Lord, Sarah C Merkel, Christine M Koellner, Julie M Curtsinger, Carl H June, James L Riley, Bruce L Levine, Jeffrey S Miller, Claudio G Brunstein, John E Wagner, Bruce R Blazar, Keli L Hippen
BACKGROUND AIMS: Thymic-derived regulatory T cells (tTreg) are critical regulators of the immune system. Adoptive tTreg transfer is a curative therapy for murine models of autoimmunity, graft rejection, and graft-versus-host disease (GVHD). We previously completed a "first-in-human" clinical trial using in vitro expanded umbilical cord blood (UCB)-derived tTreg to prevent GVHD in patients undergoing UCB hematopoietic stem cell transplantation (HSCT). tTreg were safe and demonstrated clinical efficacy, but low yield prevented further dose escalation...
February 2017: Cytotherapy
https://www.readbyqxmd.com/read/27855210/potent-and-broad-inhibition-of-hiv-1-by-a-peptide-from-the-gp41-heptad-repeat-2-domain-conjugated-to-the-cxcr4-amino-terminus
#9
George J Leslie, Jianbin Wang, Max W Richardson, Beth S Haggarty, Kevin L Hua, Jennifer Duong, Anthony J Secreto, Andrea P O Jordon, Josephine Romano, Kritika E Kumar, Joshua J DeClercq, Philip D Gregory, Carl H June, Michael J Root, James L Riley, Michael C Holmes, James A Hoxie
HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and over-expressed on the cell surface. We hypothesized that potent anti-HIV activity could be achieved if a 34 amino acid peptide from HR2 (C34) were brought to the site of virus-cell interactions by conjugation to the amino termini of HIV-1 coreceptors CCR5 or CXCR4...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27834632/viral-factors-in-influenza-pandemic-risk-assessment
#10
Marc Lipsitch, Wendy Barclay, Rahul Raman, Charles J Russell, Jessica A Belser, Sarah Cobey, Peter M Kasson, James O Lloyd-Smith, Sebastian Maurer-Stroh, Steven Riley, Catherine Aa Beauchemin, Trevor Bedford, Thomas C Friedrich, Andreas Handel, Sander Herfst, Pablo R Murcia, Benjamin Roche, Claus O Wilke, Colin A Russell
The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by detection of a closely related precursor in an animal or human. Nonetheless, influenza surveillance efforts are expanding, prompting a need for tools to assess the pandemic risk posed by a detected virus. The goal would be to use genetic sequence and/or biological assays of viral traits to identify those non-human influenza viruses with the greatest risk of evolving into pandemic threats, and/or to understand drivers of such evolution, to prioritize pandemic prevention or response measures...
November 11, 2016: ELife
https://www.readbyqxmd.com/read/27812885/pediatric-emergency-medicine-point-of-care-ultrasound-summary-of-the-evidence
#11
REVIEW
Jennifer R Marin, Alyssa M Abo, Alexander C Arroyo, Stephanie J Doniger, Jason W Fischer, Rachel Rempell, Brandi Gary, James F Holmes, David O Kessler, Samuel H F Lam, Marla C Levine, Jason A Levy, Alice Murray, Lorraine Ng, Vicki E Noble, Daniela Ramirez-Schrempp, David C Riley, Turandot Saul, Vaishali Shah, Adam B Sivitz, Ee Tein Tay, David Teng, Lindsey Chaudoin, James W Tsung, Rebecca L Vieira, Yaffa M Vitberg, Resa E Lewiss
The utility of point-of-care ultrasound is well supported by the medical literature. Consequently, pediatric emergency medicine providers have embraced this technology in everyday practice. Recently, the American Academy of Pediatrics published a policy statement endorsing the use of point-of-care ultrasound by pediatric emergency medicine providers.  To date, there is no standard guideline for the practice of point-of-care ultrasound for this specialty. This document serves as an initial step in the detailed "how to" and description of individual point-of-care ultrasound examinations...
December 2016: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/27807864/integrated-approach-to-reduce-perinatal-adverse-events-standardized-processes-interdisciplinary-teamwork-training-and-performance-feedback
#12
William Riley, James W Begun, Les Meredith, Kristi K Miller, Kathy Connolly, Rebecca Price, Janet H Muri, Mac McCullough, Stanley Davis
OBJECTIVE: To improve safety practices and reduce adverse events in perinatal units of acute care hospitals. DATA SOURCES: Primary data collected from perinatal units of 14 hospitals participating in the intervention between 2008 and 2012. Baseline secondary data collected from the same hospitals between 2006 and 2007. STUDY DESIGN: A prospective study involving 342,754 deliveries was conducted using a quality improvement collaborative that supported three primary interventions...
December 2016: Health Services Research
https://www.readbyqxmd.com/read/27790373/techcare-mobile-assessment-and-therapy-for-psychosis-an-intervention-for-clients-in-the-early-intervention-service-a-feasibility-study-protocol
#13
Nusrat Husain, Nadeem Gire, James Kelly, Joy Duxbury, Mick McKeown, Miv Riley, Christopher Dj Taylor, Peter J Taylor, Richard Emsley, Saeed Farooq, Neil Caton, Farooq Naeem, David Kingdon, Imran Chaudhry
OBJECTIVES: Technological advances in healthcare have shown promise when delivering interventions for mental health problems such as psychosis. The aim of this project is to develop a mobile phone intervention for people with psychosis and to conduct a feasibility study of the TechCare App. METHODS: The TechCare App will assess participant's symptoms and respond with a personalised guided self-help-based psychological intervention with the aim of exploring feasibility and acceptability...
2016: SAGE Open Medicine
https://www.readbyqxmd.com/read/27765481/cost-analysis-of-the-history-ecg-age-risk-factors-and-initial-troponin-heart-pathway-randomized-control-trial
#14
Robert F Riley, Chadwick D Miller, Gregory B Russell, Erin N Harper, Brian C Hiestand, James W Hoekstra, Cedric W Lefebvre, Bret A Nicks, David M Cline, Kim L Askew, Simon A Mahler
INTRODUCTION: The HEART Pathway is a diagnostic protocol designed to identify low-risk patients presenting to the emergency department with chest pain that are safe for early discharge. This protocol has been shown to significantly decrease health care resource utilization compared with usual care. However, the impact of the HEART Pathway on the cost of care has yet to be reported. METHODS AND RESULTS: We performed a cost analysis of patients enrolled in the HEART Pathway trial, which randomized participants to either usual care or the HEART Pathway protocol...
January 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27671167/targeted-next-generation-sequencing-identifies-markers-of-response-to-pd-1-blockade
#15
Douglas B Johnson, Garrett M Frampton, Matthew J Rioth, Erik Yusko, Yaomin Xu, Xingyi Guo, Riley C Ennis, David Fabrizio, Zachary R Chalmers, Joel Greenbowe, Siraj M Ali, Sohail Balasubramanian, James X Sun, Yuting He, Dennie T Frederick, Igor Puzanov, Justin M Balko, Justin M Cates, Jeffrey S Ross, Catherine Sanders, Harlan Robins, Yu Shyr, Vincent A Miller, Philip J Stephens, Ryan J Sullivan, Jeffrey A Sosman, Christine M Lovly
Therapeutic antibodies blocking programmed death-1 and its ligand (PD-1/PD-L1) induce durable responses in a substantial fraction of melanoma patients. We sought to determine whether the number and/or type of mutations identified using a next-generation sequencing (NGS) panel available in the clinic was correlated with response to anti-PD-1 in melanoma. Using archival melanoma samples from anti-PD-1/PD-L1-treated patients, we performed hybrid capture-based NGS on 236-315 genes and T-cell receptor (TCR) sequencing on initial and validation cohorts from two centers...
November 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27642636/lack-of-immunoediting-in-murine-pancreatic-cancer-reversed-with-neoantigen
#16
Rebecca A Evans, Mark S Diamond, Andrew J Rech, Timothy Chao, Max W Richardson, Jeffrey H Lin, David L Bajor, Katelyn T Byrne, Ben Z Stanger, James L Riley, Nune Markosyan, Rafael Winograd, Robert H Vonderheide
In carcinogen-driven cancers, a high mutational burden results in neoepitopes that can be recognized immunologically. Such carcinogen-induced tumors may evade this immune response through "immunoediting," whereby tumors adapt to immune pressure and escape T cell-mediated killing. Many tumors lack a high neoepitope burden, and it remains unclear whether immunoediting occurs in such cases. Here, we evaluated T cell immunity in an autochthonous mouse model of pancreatic cancer and found a low mutational burden, absence of predicted neoepitopes derived from tumor mutations, and resistance to checkpoint immunotherapy...
September 8, 2016: JCI Insight
https://www.readbyqxmd.com/read/27641049/conservation-implications-of-physiological-carry-over-effects-in-bats-recovering-from-white-nose-syndrome
#17
Christina M Davy, Gabriela F Mastromonaco, Julia L Riley, James H Baxter-Gilbert, Heather Mayberry, Craig K R Willis
Although it is well documented that infectious diseases can pose threats to biodiversity, the potential long-term consequences of pathogen exposure on individual fitness and its effects on population viability have rarely been studied. We tested the hypothesis that pathogen exposure causes physiological carry-over effects with a pathogen that is uniquely suited to this question because the infection period is specific and time limited. The fungus Pseudogymnoascus destructans causes white-nose syndrome (WNS) in hibernating bats, which either die due to the infection while hibernating or recover following emergence from hibernation...
September 18, 2016: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/27640987/hypertension-treatment-and-concern-about-falling-baseline-data-from-the-systolic-blood-pressure-intervention-trial
#18
Dan R Berlowitz, Tonya Breaux-Shropshire, Capri G Foy, Lisa H Gren, Lewis Kazis, Alan J Lerner, Jill C Newman, James R Powell, William T Riley, Robert Rosman, Virginia G Wadley, Julie A Williams
OBJECTIVES: To determine the extent of concern about falling in older adults with hypertension, whether lower blood pressure (BP) and greater use of antihypertensive medications are associated with greater concern about falling, and whether lower BP has a greater effect on concern about falling in older and more functionally impaired individuals. DESIGN: Secondary analysis involving cross-sectional study of baseline characteristics of participants enrolled in the Systolic Blood Pressure Intervention Trial (SPRINT)...
November 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27559473/improving-the-diagnostic-quality-and-adequacy-of-shoulder-radiographs-in-a-district-general-hospital
#19
Bethany Richards, James Riley, Adnan Saithna
A high rate of suboptimal shoulder radiographs was identified during a service evaluation exercise in our orthopaedic outpatient clinics. Inadequate radiographs require a return to the radiology department for further imaging, a resultant increased workload, delays in the clinic, increased radiation for patients, and inconvenience and decreased patient satisfaction. Furthermore, if a sub-optimal radiograph is accepted there is concern that diagnoses may be missed. The aim of this project was to decrease the rate of suboptimal radiographs by delivering a teaching package directed towards quality improvement...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27549442/decreasing-malpractice-claims-by-reducing-preventable-perinatal-harm
#20
William Riley, Les W Meredith, Rebecca Price, Kristi K Miller, James W Begun, Mac McCullough, Stanley Davis
OBJECTIVE: To evaluate the association of improved patient safety practices with medical malpractice claims and costs in the perinatal units of acute care hospitals. DATA SOURCES: Malpractice and harm data from participating hospitals; litigation records and medical malpractice claims data from American Excess Insurance Exchange, RRG, whose data are managed by Premier Insurance Management Services, Inc. (owned by Premier Inc., a health care improvement company)...
December 2016: Health Services Research
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