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Ara 2 and diabetes

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https://www.readbyqxmd.com/read/29521741/mortality-of-the-severely-obese-a-population-study
#1
Osama M Moussa, Simon Erridge, Swathikan Chidambaram, Paul Ziprin, Ara Darzi, Sanjay Purkayastha
OBJECTIVE: This study aimed to analyze the Clinical Practice Research Datalink to identify the prognostic factors of all-cause mortality in the severely obese. BACKGROUND: Patients who are severely obese [body mass index (BMI) ≥35 kg/m] are at increased risk of all-cause mortality as a result of metabolic sequelae including hyperlipidemia, hypertension, and diabetes. Bariatric surgery has been shown to reduce the severity of the metabolic complications of obesity...
March 8, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29478524/the-inhibitory-potential-of-montmorency-tart-cherry-on-key-enzymes-relevant-to-type-2-diabetes-and-cardiovascular-disease
#2
Ara Kirakosyan, Enrique Gutierrez, Beatriz Ramos Solano, E Mitchell Seymour, Steven F Bolling
The inhibitory potential of Montmorency tart cherry on glycemia regulation and other enzymes relevant to inflammation were evaluated. Tart cherry has superior inhibitory potential against key enzymes associated with carbohydrate digestion linked to hypertension. In particular, α-amylase activity was significantly inhibited (IC50 = 3.46 ± 0.06 mg/ml), whereas we observed mild inhibition of α-glucosidase (IC50 = 11.64 ± 0.65 mg/ml). Angiotensin I-converting enzyme inhibition was also strong by about 89%...
June 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329333/wide-range-screening-of-anti-inflammatory-compounds-in-tomato-using-lc-ms-and-elucidating-the-mechanism-of-their-functions
#3
Shinsuke Mohri, Haruya Takahashi, Maiko Sakai, Shingo Takahashi, Naoko Waki, Koichi Aizawa, Hiroyuki Suganuma, Takeshi Ara, Yasuki Matsumura, Daisuke Shibata, Tsuyoshi Goto, Teruo Kawada
Obesity-induced chronic inflammation is a key factor in type 2 diabetes. A vicious cycle involving pro-inflammatory mediators between adipocytes and macrophages is a common cause of chronic inflammation in the adipose tissue. Tomato is one of the most popular vegetables and is associated with a reduced risk of diabetes. However, the molecular mechanism underlying the effect of tomato on diabetes is unclear. In this study, we focused on anti-inflammatory compounds in tomato. We found that the extract of tomato reduced plasma glucose and inflammatory markers in mice...
2018: PloS One
https://www.readbyqxmd.com/read/29259227/inhibition-of-c1-ten-ptpase-activity-reduces-insulin-resistance-through-irs-1-and-ampk-pathways
#4
Heeyoon Jeong, Ara Koh, Jiyoun Lee, Dohyun Park, Jung Ok Lee, Mi Nam Lee, Kyung-Jin Jo, Huynh Nguyen Khanh Tran, Eui Kim, Byung-Sun Min, Hyeon Soo Kim, Per-Olof Berggren, Sung Ho Ryu
Insulin resistance causes type 2 diabetes; therefore, increasing insulin sensitivity is a therapeutic approach against type 2 diabetes. Activating AMP-activated protein kinase (AMPK) is an effective approach for treating diabetes, and reduced insulin receptor substrate-1 (IRS-1) protein levels have been suggested as a molecular mechanism causing insulin resistance. Thus, dual targeting of AMPK and IRS-1 might provide an ideal way to treat diabetes. We found that 15,16-dihydrotanshinone I (DHTS), as a C1-Ten protein tyrosine phosphatase inhibitor, increased IRS-1 stability, improved glucose tolerance and reduced muscle atrophy...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29180649/hepatic-protein-tyrosine-phosphatase-receptor-gamma-links-obesity-induced-inflammation-to-insulin-resistance
#5
Xavier Brenachot, Giorgio Ramadori, Rafael M Ioris, Christelle Veyrat-Durebex, Jordi Altirriba, Ebru Aras, Sanda Ljubicic, Daisuke Kohno, Salvatore Fabbiano, Sophie Clement, Nicolas Goossens, Mirko Trajkovski, Sheila Harroch, Francesco Negro, Roberto Coppari
Obesity-induced inflammation engenders insulin resistance and type 2 diabetes mellitus (T2DM) but the inflammatory effectors linking obesity to insulin resistance are incompletely understood. Here, we show that hepatic expression of Protein Tyrosine Phosphatase Receptor Gamma (PTPR-γ) is stimulated by inflammation in obese/T2DM mice and positively correlates with indices of inflammation and insulin resistance in humans. NF-κB binds to the promoter of Ptprg and is required for inflammation-induced PTPR-γ expression...
November 28, 2017: Nature Communications
https://www.readbyqxmd.com/read/29146657/a-randomised-controlled-trial-of-a-duodenal-jejunal-bypass-sleeve-device-endobarrier-compared-with-standard-medical-therapy-for-the-management-of-obese-subjects-with-type-2-diabetes-mellitus
#6
Michael Alan Glaysher, Aruchuna Mohanaruban, Christina Gabriele Prechtl, Anthony P Goldstone, Alexander Dimitri Miras, Joanne Lord, Navpreet Chhina, Emanuela Falaschetti, Nicholas Andrew Johnson, Werd Al-Najim, Claire Smith, Jia V Li, Mayank Patel, Ahmed R Ahmed, Michael Moore, Neil Poulter, Stephen Bloom, Ara Darzi, Carel Le Roux, James P Byrne, Julian P Teare
INTRODUCTION: The prevalence of obesity and obesity-related diseases, including type 2 diabetes mellitus (T2DM), is increasing. Exclusion of the foregut, as occurs in Roux-en-Y gastric bypass, has a key role in the metabolic improvements that occur following bariatric surgery, which are independent of weight loss. Endoscopically placed duodenal-jejunal bypass sleeve devices, such as the EndoBarrier (GI Dynamics, Lexington, Massachusetts, USA), have been designed to create an impermeable barrier between chyme exiting the stomach and the mucosa of the duodenum and proximal jejunum...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28686542/polyunsaturated-fatty-acids-and-endocannabinoids-in-health-and-disease
#7
Hércules Rezende Freitas, Alinny Rosendo Isaac, Renato Malcher-Lopes, Bruno Lourenço Diaz, Isis Hara Trevenzoli, Ricardo Augusto De Melo Reis
Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) synthesized from membrane phospholipids and used as a precursor for endocannabinoids (ECs). They mediate significant effects in the fine-tune adjustment of body homeostasis. Phyto- and synthetic cannabinoids also rule the daily life of billions worldwide, as they are involved in obesity, depression and drug addiction. Consequently, there is growing interest to reveal novel active compounds in this field...
July 7, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28647723/a-retrospective-cohort-study-of-high-impact-users-among-patients-with-cerebrovascular-conditions
#8
Ahsan Rao, Alice Jones, Alex Bottle, Ara Darzi, Paul Aylin
OBJECTIVE: To apply group-based trajectory modelling (GBTM) to the hospital administrative data to evaluate, model and visualise trends and changes in the frequency of long-term hospital care use of the subgroups of patients with cerebrovascular conditions. DESIGN: A retrospective cohort study of patients with cerebrovascular conditions. SETTINGS: Secondary care of all patients with cerebrovascular conditions admitted to English National Hospital Service hospitals...
June 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28588970/modifying-the-interagency-emergency-health-kit-to-include-treatment-for-non-communicable-diseases-in-natural-disasters-and-complex-emergencies
#9
Marcello Tonelli, Natasha Wiebe, Brian Nadler, Ara Darzi, Shahnawaz Rasheed
The Interagency Emergency Health Kit (IEHK) provides a standard package of medicines and simple medical devices for aid agencies to use in emergencies such as disasters and armed conflicts. Despite the increasing burden of non-communicable diseases (NCDs) in such settings, the IEHK includes few drugs and devices for management of NCDs. Using published data to model the population burden of acute and chronic presentations of NCDs in emergency-prone regions, we estimated the quantity of medications and devices that should be included in the IEHK...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28345395/evaluation-of-the-predictive-value-of-cha-2-ds-2-vasc-score-for-in-stent-restenosis
#10
Samet Yilmaz, Mehmet Kadri Akboga, Dursun Aras, Serkan Topaloglu
The CHA2 DS2 -VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, previous stroke, vascular disease, age 65-74 years, female gender) score is used to estimate thromboembolic risk in atrial fibrillation (AF). Its usefulness in predicting in-stent restenosis (ISR) is unknown. We evaluated the predictive value of the CHA2 DS2 -VASc score in AF-free patients who have undergone stent implantation. A total of 1350 patients who underwent coronary angiography and successful bare-metal stent implantation were analyzed...
January 2018: Angiology
https://www.readbyqxmd.com/read/28118838/the-cost-effectiveness-of-changes-to-the-care-pathway-used-to-identify-depression-and-provide-treatment-amongst-people-with-diabetes-in-england-a-model-based-economic-evaluation
#11
Ben Kearns, R Rafia, J Leaviss, L Preston, J E Brazier, S Palmer, R Ara
BACKGROUND: Diabetes is associated with premature death and a number of serious complications. The presence of comorbid depression makes these outcomes more likely and results in increased healthcare costs. The aim of this work was to assess the health economic outcomes associated with having both diabetes and depression, and assess the cost-effectiveness of potential policy changes to improve the care pathway: improved opportunistic screening for depression, collaborative care for depression treatment, and the combination of both...
January 24, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28114076/a-multi-technique-reconfigurable-electrochemical-biosensor-enabling-personal-health-monitoring-in-mobile-devices
#12
Alexander Sun, A G Venkatesh, Drew A Hall
This paper describes the design and characterization of a reconfigurable, multi-technique electrochemical biosensor designed for direct integration into smartphone and wearable technologies to enable remote and accurate personal health monitoring. By repurposing components from one mode to the next, the biosensor's potentiostat is able reconfigure itself into three different measurements modes to perform amperometric, potentiometric, and impedance spectroscopic tests all with minimal redundant devices. A [Formula: see text] PCB prototype of the module was developed with discrete components and tested using Google's Project Ara modular smartphone...
September 26, 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28113176/a-multi-technique-reconfigurable-electrochemical-biosensor-enabling-personal-health-monitoring-in-mobile-devices
#13
Alexander Sun, A G Venkatesh, Drew A Hall
This paper describes the design and characterization of a reconfigurable, multi-technique electrochemical biosensor designed for direct integration into smartphone and wearable technologies to enable remote and accurate personal health monitoring. By repurposing components from one mode to the next, the biosensor's potentiostat is able reconfigure itself into three different measurements modes to perform amperometric, potentiometric, and impedance spectroscopic tests all with minimal redundant devices. A [Formula: see text] PCB prototype of the module was developed with discrete components and tested using Google's Project Ara modular smartphone...
October 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/27931553/change-in-left-ventricular-systolic-function-in-patients-with-st-elevation-myocardial-infarction-evidence-for-smoker-s-paradox-or-pseudo-paradox
#14
Burak Acar, Ozcan Ozeke, Sefa Unal, Mustafa Karakurt, Meryem Kara, Ozgur Kirbas, Fatih Sen, Ahmet Korkmaz, Dursun Aras, Sinan Aydogdu
BACKGROUND: The 'smoker's paradox' refers to the observation of favorable prognosis in current smokers following an acute ST elevation myocardial infarction (STEMI) in the era of fibrinolysis, however, several STEMI studies have demonstrated conflicting results in patients undergoing primary percutaneous coronary intervention (p-PCI). OBJECTIVE: Aim of the current study was to evaluate the impact of cigarette smoking on left ventricular function in STEMI patients undergoing p-PCI...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27681888/a-single-dose-escalation-study-to-evaluate-the-safety-and-pharmacokinetics-of-orally-administered-des-aspartate-angiotensin-i-in-healthy-subjects
#15
Ko-Onn Lee, Chin-Meng Khoo, Balram Chowbay, Yiong-Huak Chan, Meng-Kwoon Sim
Des-aspartate-angiotensin I (DAA-I) is an endogenous angiotensin peptide and a prototype angiotensin receptor agonist (ARA). It acts on the angiotensin AT1 receptor and antagonises the deleterious actions of angiotensin II. DAA-I attenuates animal models of human disease in which angiotensin II has been implicated, such as cardiac hypertrophy, neointima formation, arteriosclerosis, renal failure, post-infarction injuries, diabetes, viral infection, chemical-induced inflammation, heat stroke, cancer, and gamma radiation lethality...
December 2016: Drugs in R&D
https://www.readbyqxmd.com/read/27668120/systematic-review-of-hospital-readmissions-in-stroke-patients
#16
REVIEW
Ahsan Rao, Emily Barrow, Sabine Vuik, Ara Darzi, Paul Aylin
Background. Previous evidence on factors and causes of readmissions associated with high-impact users of stroke is scanty. The aim of the study was to investigate common causes and pattern of short- and long-term readmissions stroke patients by conducting a systematic review of studies using hospital administrative data. Common risk factors associated with the change of readmission rate were also examined. Methods. The literature search was conducted from 15 February to 15 March 2016 using various databases, such as Medline, Embase, and Web of Science...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27279850/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-albuminuria-in-type-2-diabetic-patients-a-pilot-study
#17
Cüneyt Kahraman, Nilüfer Kuzeyli Kahraman, Bekir Aras, Süleyman Coşgun, Erim Gülcan
INTRODUCTION: Diabetes mellitus (DM) has become a global economic burden due to treatment costs and attendant complications. Albuminuria is the precursor of end stage renal failure and is an inflammatory process. In the recent past, it has been reported that the neutrophil/lymphocyte ratio (NLR), which is a cost-effective and accessible marker, may be a favorable indicator of the inflammatory status. The aim of this study was to investigate the relationship between the neutrophil/lymphocyte ratio and the presence and level of diabetic nephropathy (DN)...
June 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27169860/subclinical-inflammation-in-relation-to-insulin-resistance-in-prediabetic-subjects-with-nonalcoholic-fatty-liver-disease
#18
Israt Ara Hossain, Salima Akter, Farjana Rahman Bhuiyan, Mijanur Rahman Shah, Mohammad Khalilur Rahman, Liaquat Ali
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease commonly associated with obesity, type 2 diabetes, and inflammation-all features of insulin resistant syndrome. However, very limited data are available regarding the association of subclinical inflammation and insulin resistance with NAFLD in a prediabetic state. We, therefore, conducted the study to assess this relationship among this population. METHODS: We studied a cross-sectional analytical design of 140 [male/female, 77/63; age in years (ranges), 45 (25-68)] prediabetic subjects after confirming with 75 g oral glucose tolerance test...
May 11, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/26993471/incentives-in-diabetic-eye-assessment-by-screening-ideas-study-protocol-of-a-three-arm-randomized-controlled-trial-using-financial-incentives-to-increase-screening-uptake-in-london
#19
RANDOMIZED CONTROLLED TRIAL
Gaby Judah, Ivo Vlaev, Laura Gunn, Dominic King, Derek King, Jonathan Valabhji, Ara Darzi, Colin Bicknell
BACKGROUND: Diabetes is an increasing public health problem in the UK and globally. Diabetic retinopathy is a microvascular complication of diabetes, and is one of the leading causes of blindness in the UK working age population. The diabetic eye screening programme in England aims to invite all people with diabetes aged 12 or over for retinal photography to screen for the presence of diabetic retinopathy. However, attendance rates are only 81 %, leaving many people at risk of preventable sight loss...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/26957386/low-grip-strength-and-prediabetes-in-normal-weight-adults
#20
Arch G Mainous, Rebecca J Tanner, Stephen D Anton, Ara Jo
INTRODUCTION: Detection of prediabetes is an important step in diabetes prevention in primary care. Risk stratification of healthy-weight individuals for detection of prediabetes is necessary to avoid missed opportunities for diabetes prevention. METHODS: Using data from the 2011 to 2012 National Health and Nutrition Examination Survey, we studied the relationship between combined handgrip strength, a proxy for lean muscle mass, and prediabetes among adults aged ≥20 years without diagnosed or undiagnosed diabetes who had a healthy body mass index (18...
March 2016: Journal of the American Board of Family Medicine: JABFM
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