Read by QxMD icon Read

Ara 2 and diabetes

Ko-Onn Lee, Chin-Meng Khoo, Balram Chowbay, Yiong-Huak Chan, Meng-Kwoon Sim
Des-aspartate-angiotensin I (DAA-I) is an endogenous angiotensin peptide and a prototype angiotensin receptor agonist (ARA). It acts on the angiotensin AT1 receptor and antagonises the deleterious actions of angiotensin II. DAA-I attenuates animal models of human disease in which angiotensin II has been implicated, such as cardiac hypertrophy, neointima formation, arteriosclerosis, renal failure, post-infarction injuries, diabetes, viral infection, chemical-induced inflammation, heat stroke, cancer, and gamma radiation lethality...
September 28, 2016: Drugs in R&D
Ahsan Rao, Emily Barrow, Sabine Vuik, Ara Darzi, Paul Aylin
Background. Previous evidence on factors and causes of readmissions associated with high-impact users of stroke is scanty. The aim of the study was to investigate common causes and pattern of short- and long-term readmissions stroke patients by conducting a systematic review of studies using hospital administrative data. Common risk factors associated with the change of readmission rate were also examined. Methods. The literature search was conducted from 15 February to 15 March 2016 using various databases, such as Medline, Embase, and Web of Science...
2016: Stroke Research and Treatment
Cüneyt Kahraman, Nilüfer Kuzeyli Kahraman, Bekir Aras, Süleyman Coşgun, Erim Gülcan
INTRODUCTION: Diabetes mellitus (DM) has become a global economic burden due to treatment costs and attendant complications. Albuminuria is the precursor of end stage renal failure and is an inflammatory process. In the recent past, it has been reported that the neutrophil/lymphocyte ratio (NLR), which is a cost-effective and accessible marker, may be a favorable indicator of the inflammatory status. The aim of this study was to investigate the relationship between the neutrophil/lymphocyte ratio and the presence and level of diabetic nephropathy (DN)...
June 1, 2016: Archives of Medical Science: AMS
Israt Ara Hossain, Salima Akter, Farjana Rahman Bhuiyan, Mijanur Rahman Shah, Mohammad Khalilur Rahman, Liaquat Ali
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease commonly associated with obesity, type 2 diabetes, and inflammation-all features of insulin resistant syndrome. However, very limited data are available regarding the association of subclinical inflammation and insulin resistance with NAFLD in a prediabetic state. We, therefore, conducted the study to assess this relationship among this population. METHODS: We studied a cross-sectional analytical design of 140 [male/female, 77/63; age in years (ranges), 45 (25-68)] prediabetic subjects after confirming with 75 g oral glucose tolerance test...
2016: BMC Research Notes
Gaby Judah, Ivo Vlaev, Laura Gunn, Dominic King, Derek King, Jonathan Valabhji, Ara Darzi, Colin Bicknell
BACKGROUND: Diabetes is an increasing public health problem in the UK and globally. Diabetic retinopathy is a microvascular complication of diabetes, and is one of the leading causes of blindness in the UK working age population. The diabetic eye screening programme in England aims to invite all people with diabetes aged 12 or over for retinal photography to screen for the presence of diabetic retinopathy. However, attendance rates are only 81 %, leaving many people at risk of preventable sight loss...
2016: BMC Ophthalmology
Arch G Mainous, Rebecca J Tanner, Stephen D Anton, Ara Jo
INTRODUCTION: Detection of prediabetes is an important step in diabetes prevention in primary care. Risk stratification of healthy-weight individuals for detection of prediabetes is necessary to avoid missed opportunities for diabetes prevention. METHODS: Using data from the 2011 to 2012 National Health and Nutrition Examination Survey, we studied the relationship between combined handgrip strength, a proxy for lean muscle mass, and prediabetes among adults aged ≥20 years without diagnosed or undiagnosed diabetes who had a healthy body mass index (18...
March 2016: Journal of the American Board of Family Medicine: JABFM
Alessandro P Delitala, Giovanni M Pes, Giuseppe Fanciulli, Margherita Maioli, Giannina Secchi, Franca Sanciu, Giuseppe Delitala, Roberto Manetti
AIM OF THE STUDY: The aim of the present study was to define the frequency of organ-specific and non-organ-specific autoantibodies in a cohort of Latent Autoimmune Diabetes in Adults (LADA) patients and to test whether multiple antibodies positivity could be a predictor of early insulin dependence. MATERIALS AND METHODS: We enrolled 210 LADA and 210 type 2 diabetes mellitus (T2D) patients. In all subjects anti-islet antigen-2 (IA-2Ab), anti-thyroperoxidase (TPOAb), anti-zinc transporter 8 (ZnT8Ab), anti-nuclear (ANA), anti-parietal cell (APCA), anti-smooth muscle (ASMA), anti-mitochondrial (AMA), anti-liver kidney microsomes (LKM), and anti-reticulin (ARA) circulating antibodies were assessed...
August 2016: Endocrine Research
Koukou Li, Min Yu, Yang Hu, Guangming Ren, Tingting Zang, Xiuhong Xu, Juanjuan Qu
Chronic pancreatitis (CP) is a progressive inflammation of pancreas characterized by irreversible morphologic change and dysfunction. Patients with chronic pancreatitis often present with abdominal pain, diarrhoea, jaundice, weight loss and the development of diabetes. Polysaccharides of Ganoderma lucidum strain S3 (GLPS3) possess antioxidative and immunomodulatory activities. This study was to characterize chemical structures of GLPS3 and determine their effects on diethyldithiocarbamate (DDC)-induced CP in mice...
March 5, 2016: Chemico-biological Interactions
Hutan Ashrafian, Leanne Harling, Tania Toma, Christina Athanasiou, Nikolaos Nikiteas, Evangelos Efthimiou, Ara Darzi, Thanos Athanasiou
BACKGROUND: Type 1 diabetes mellitus (T1DM) has a rising global prevalence. Although it is vastly outnumbered by type 2 diabetes mellitus rates, it remains a persistent worldwide source of morbidity and mortality. Increasingly, its sufferers are afflicted by obesity and its complications. The objective of the study is to quantify the effects of bariatric surgery on T1DM by appraising the primary outcomes of glycosylated haemoglobin (HbA1c), insulin requirements and body mass index (BMI)...
August 2016: Obesity Surgery
Masaaki Watanabe, Torbjörn Lundgren, Yu Saito, Anthony Cerami, Michael Brines, Claes-Göran Östenson, Makiko Kumagai-Braesch
BACKGROUND: Erythropoietin exerts anti-inflammatory, antiapoptotic, and cytoprotective effects in addition to its hematopoietic action. A nonhematopoietic erythropoietin analogue, ARA 290, has similar properties. The efficacy of pancreatic islet transplantation (PITx) is reduced due to islet damage that occurs during isolation and from the severe inflammatory reactions caused by the transplantation procedure. We investigated whether ARA 290 protects islets and ameliorates inflammatory responses following PITx thus improving engraftment...
March 2016: Transplantation
Rodolfo Pini, Gianluca Faggioli, Antonio Freyrie, Enrico Gallitto, Chiara Mascoli, Claudio Bianchini Massoni, Andrea Stella, Mauro Gargiulo
OBJECTIVE: Fenestrated endovascular aortic repair (fEVAR) is being used increasingly in the treatment of complex aortic aneurysms; however, this procedure can be associated with visceral and renal complications. Because the causes of possible renal function (RF) impairment have not been fully examined yet, we conducted a study to investigate whether there are risk factors associate with renal ischemic lesions (RILs) and if they influence RF in patients treated for complex aortic aneurysm with fEVAR...
February 2016: Journal of Vascular Surgery
Klaus Linni, Ara Ugurluoglu, Manuela Aspalter, Wolfgang Hitzl, Thomas Hölzenbein
OBJECTIVE: The aim of this study was to compare the clinical and hemodynamic outcomes of plain vs paclitaxel-coated percutaneous transluminal angioplasty (PTA) in patients with infrainguinal vein bypass stenosis. METHODS: A single-center retrospective analysis was conducted of consecutive patients treated by infrainguinal bypass PTA. Primary study end points were primary and assisted primary patency. Secondary end points were clinical and hemodynamic improvement, limb salvage, and survival...
February 2016: Journal of Vascular Surgery
Farzana Saleh, Ferdous Ara, Shirin Jahan Mumu, Md Abdul Hafez
BACKGROUND: The management of diabetes requires a fundamental change in the lifestyle of patients, and one of the important outcome criteria is the quality of life. We assessed the health-related quality of life (HR-QoL) and examined the factors associated with it in type 2 diabetes. METHODS: An analytical cross-sectional study was conducted among 500 type 2 diabetes patients (age >25 years and duration of diabetes >1 year). They were selected conveniently from the Out-Patient department of the Bangladesh Institute of Health Sciences Hospital...
2015: BMC Research Notes
Yong Ryoul Yang, Hyun-Jun Jang, Sun-Sil Choi, Yong Hwa Lee, Gyun Hui Lee, Young-Kyo Seo, Jang Hyun Choi, Dohyun Park, Ara Koh, Il Shin Kim, Ho Lee, Sung Ho Ryu, Pann-Ghill Suh
AIMS/HYPOTHESIS: O-GlcNAcylation plays a role as a metabolic sensor regulating cellular signalling, transcription and metabolism. Transcription factors and signalling pathways related to metabolism are modulated by N-acetyl-glucosamine (O-GlcNAc) modification. Aberrant regulation of O-GlcNAcylation is closely linked to insulin resistance, type 2 diabetes and obesity. Current evidence shows that increased O-GlcNAcylation negatively regulates insulin signalling, which is associated with insulin resistance and type 2 diabetes...
December 2015: Diabetologia
Mehmet Tokmak, Inci Baltepe Altiok, Mustafa Guven, Adem Bozkurt Aras, Murat Cosar
Diagnosis, treatment, and surgery for lumbar disc herniations have existed for over a century. However, during the last three decades, there have been many new developments in imaging techniques, surgical procedures, physical medicine, and rehabilitation. In light of this, the most effective and appropriate treatment is controversial. Spontaneous regression of sequestrated, extruded, or protruded disc herniation has often been reported in the literature, although it is still a rare phenomenon. After a thorough review of the literature, we did not find any case report about this phenomenon after weight loss...
2015: Turkish Neurosurgery
Marta Barreto de Medeiros Nóbrega, Roque Aras, Eduardo Martins Netto, Ricardo David Couto, Alexandre Magno da Nóbrega Marinho, João Luís da Silva, Víctor Nóbrega Quintas Colares, Priscilla Leite Campelo, Marcos André Lima Nunes
OBJECTIVE: Diabetes mellitus is the main cause of Charcot neuroarthropathy and is clinically classified as follows: Charcot foot, acute Charcot foot (ACF) when there is inflammation, and inactive Charcot foot when inflammatory signs are absent. The aim of this study was to identify the risk factors for ACF in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: A matched case-control study was conducted to assess the factors associated with acute Charcot foot from February 2000 until September 2012...
June 2015: Archives of Endocrinology and Metabolism
Shazia Awan, Seema Bibi, Asadullah Makhdoom, Sumaiya Farooq, Tahir Sm, Roshan Ara Qazi
OBJECTIVE: To compare the adverse fetometernal out come in overweight and normal weight pregnant women. METHODS: This comparative cohort study was conducted from 1(st) October 2010 to 30 September 2012. Total 200 gravid women 100 were overweight and 100 normal weight pregnant women with gestational age for 08-40 weeks were included. Women having BMI (25 - 29.9 Kg/m(2)) were measured overweight and included in group A and 100 women having normal BMI of 18.5 to 24...
March 2015: Pakistan Journal of Medical Sciences Quarterly
Fatih Sen, Samet Yilmaz, Kevser Gülcihan Balci, Murat Gül, Mustafa Mücahit Balci, Mehmet Kadri Akboga, Serkan Topaloglu, Ahmet Temizhan, Dursun Aras, Sinan Aydogdu
We investigated the relationship between epicardial adipose tissue (EAT) and infarct-related artery (IRA) patency before mechanical reperfusion in patients with ST-segment elevation myocardial infarction (STEMI). Patients (n = 640) were divided into 2 groups based on the thrombolysis in myocardial infarction (TIMI) flow grade. Impaired flow was defined as TIMI grades 0, 1, and 2, and normal flow was defined as TIMI 3. On the admission angiography, 65 (10.2%) patients had TIMI 3 flow, and the remaining 575 (89...
March 2016: Angiology
Tung-Min Yu, Chung-Shu Sun, Cheng-Li Lin, Chen-Yu Wang, Pi-Yi Chang, Che-Yi Chou, Ya-Wen Chuang, Bor-Jen Lee, Chia-Hung Kao
The aim of this study was to investigate the risk factors associated with end-stage renal disease (ESRD) in patients with atherosclerotic renal artery stenosis (ARAS). Information about the study participants was extracted from the National Health Insurance Research Database of Taiwan for the years 1999 through 2011. We conducted this retrospective cohort study of patients with ARAS to identify the potential risk factors associated with long-term renal outcomes. A total of 2184 patients with ARAS were enrolled, of whom 840 had ESRD and were classified as the study group, and 1344 patients who were without ESRD were included in the comparison cohort...
May 2015: Medicine (Baltimore)
Parkyong Song, Yonghoon Kwon, Kyungmoo Yea, Hyo-Youl Moon, Jong Hyuk Yoon, Jaewang Ghim, Hyunjung Hyun, Dayea Kim, Ara Koh, Per-Olof Berggren, Pann-Ghill Suh, Sung Ho Ryu
Apolipoprotein a1, which is a major lipoprotein component of high-density lipoprotein (HDL), was reported to decrease plasma glucose in type 2 diabetes. Although recent studies also have shown that apolipoprotein a1 is involved in triglyceride (TG) metabolism, the mechanisms by which apolipoprotein a1 modulates TG levels remain largely unexplored. Here we demonstrated that apolipoprotein a1 increased mitochondrial DNA and mitochondria contents through sustained AMPK activation in myotubes. This resulted in enhanced fatty acid oxidation and attenuation of free fatty acid-induced insulin resistance features in skeletal muscle...
September 2015: Cellular Signalling
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"