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JOURNAL ARTICLE
Severin Lechner, Martin Ian P Malgapo, Christian Grätz, Raphael R Steimbach, Agnes Baron, Patrick Rüther, Simon Nadal, Carmen Stumpf, Christina Loos, Xin Ku, Polina Prokofeva, Ludwig Lautenbacher, Tino Heimburg, Vivian Würf, Chen Meng, Mathias Wilhelm, Wolfgang Sippl, Karin Kleigrewe, Josch K Pauling, Karl Kramer, Aubry K Miller, Michael W Pfaffl, Maurine E Linder, Bernhard Kuster, Guillaume Médard
Drugs that target histone deacetylase (HDAC) entered the pharmacopoeia in the 2000s. However, some enigmatic phenotypes suggest off-target engagement. Here, we developed a quantitative chemical proteomics assay using immobilized HDAC inhibitors and mass spectrometry that we deployed to establish the target landscape of 53 drugs. The assay covers 9 of the 11 human zinc-dependent HDACs, questions the reported selectivity of some widely-used molecules (notably for HDAC6) and delineates how the composition of HDAC complexes influences drug potency...
April 28, 2022: Nature Chemical Biology
#22
JOURNAL ARTICLE
Lisa Musculus, Franziska Lautenbach, Simon Knöbel, Martin Leo Reinhard, Peter Weigel, Nils Gatzmaga, Andy Borchert, Maximilian Pelka
In professional soccer, players, coaches, and researchers alike recognize the importance of cognitive skills. Research addressing the relevance of cognitive skills has been based on the cognitive component skills approach (i.e., general cognitive processes) or the expert performance approach (i.e., sport-specific cognitive processes). Our project aimed to combine the strengths of both approaches to develop and validate cognitive tasks measuring inhibition and cognitive flexibility in a soccer-specific setting with a soccer-specific motor response...
2022: Frontiers in Psychology
#23
JOURNAL ARTICLE
Chongliang Luo, Md Nazmul Islam, Natalie E Sheils, John Buresh, Jenna Reps, Martijn J Schuemie, Patrick B Ryan, Mackenzie Edmondson, Rui Duan, Jiayi Tong, Arielle Marks-Anglin, Jiang Bian, Zhaoyi Chen, Talita Duarte-Salles, Sergio Fernández-Bertolín, Thomas Falconer, Chungsoo Kim, Rae Woong Park, Stephen R Pfohl, Nigam H Shah, Andrew E Williams, Hua Xu, Yujia Zhou, Ebbing Lautenbach, Jalpa A Doshi, Rachel M Werner, David A Asch, Yong Chen
Linear mixed models are commonly used in healthcare-based association analyses for analyzing multi-site data with heterogeneous site-specific random effects. Due to regulations for protecting patients' privacy, sensitive individual patient data (IPD) typically cannot be shared across sites. We propose an algorithm for fitting distributed linear mixed models (DLMMs) without sharing IPD across sites. This algorithm achieves results identical to those achieved using pooled IPD from multiple sites (i.e., the same effect size and standard error estimates), hence demonstrating the lossless property...
March 30, 2022: Nature Communications
#24
JOURNAL ARTICLE
Matthew J Ziegler, Hilary H Babcock, Sharon F Welbel, David K Warren, William E Trick, Pam Tolomeo, Jacqueline Omorogbe, Diana Garcia, Tracy Habrock-Bach, Onofre Donceras, Steven Gaynes, Leigh Cressman, Jason P Burnham, Warren Bilker, Sujan C Reddy, David Pegues, Ebbing Lautenbach, Brendan J Kelly, Barry Fuchs, Niels D Martin, Jennifer H Han
BACKGROUND: Multidrug-resistant organisms (MDROs) frequently contaminate hospital environments. We performed a multicenter, cluster-randomized, crossover trial of two methods for monitoring of terminal cleaning effectiveness. METHODS: Six intensive care units (ICUs) at three medical centers received both interventions sequentially, in randomized order. Ten surfaces were surveyed each in five rooms weekly, after terminal cleaning, with ATP monitoring or an ultraviolet fluorescent marker (UV/F)...
February 1, 2022: Clinical Infectious Diseases
#25
JOURNAL ARTICLE
Esben Elholm Madsen, Peter Krustrup, Carsten Hvid Larsen, Anne-Marie Elbe, Johan Michael Wikman, Andreas Ivarsson, Franziska Lautenbach
Background: In Denmark, the first COVID-19 pandemic lockdown resulted in a compact season finisher for elite footballers, potentially impacting their mental health. Purpose: This study aimed to investigate the protective role of resilience and the impeding role of trait anxiety on elite footballers' level and variability of well-being and emotional stability. Material and Methods: One hundred and twenty-five male elite-level players ( Mage = 25.04 ± 4.82) completed baseline measures on trait anxiety and resilience...
November 2021: Science & medicine in football
#26
JOURNAL ARTICLE
F Abudinén, I Adachi, K Adamczyk, L Aggarwal, H Ahmed, H Aihara, N Akopov, A Aloisio, N Anh Ky, D M Asner, H Atmacan, V Aushev, V Babu, S Bacher, H Bae, S Baehr, S Bahinipati, P Bambade, Sw Banerjee, S Bansal, M Barrett, J Baudot, M Bauer, A Baur, J Becker, P K Behera, J V Bennett, E Bernieri, F U Bernlochner, M Bertemes, E Bertholet, M Bessner, S Bettarini, V Bhardwaj, F Bianchi, T Bilka, S Bilokin, D Biswas, A Bobrov, D Bodrov, A Bolz, A Bozek, M Bračko, P Branchini, N Braun, R A Briere, T E Browder, A Budano, S Bussino, M Campajola, L Cao, G Casarosa, C Cecchi, D Červenkov, M-C Chang, P Chang, R Cheaib, V Chekelian, C Chen, Y-T Chen, B G Cheon, K Chilikin, K Chirapatpimol, H-E Cho, K Cho, S-J Cho, S-K Choi, S Choudhury, D Cinabro, L Corona, L M Cremaldi, S Cunliffe, T Czank, F Dattola, E De La Cruz-Burelo, G de Marino, G De Nardo, G De Pietro, R de Sangro, M Destefanis, S Dey, A De Yta-Hernandez, A Di Canto, F Di Capua, J Dingfelder, Z Doležal, I Domínguez Jiménez, T V Dong, M Dorigo, K Dort, D Dossett, S Dubey, S Duell, G Dujany, P Ecker, D Epifanov, T Ferber, D Ferlewicz, G Finocchiaro, K Flood, A Fodor, F Forti, B G Fulsom, A Gabrielli, N Gabyshev, A Gaz, A Gellrich, G Giakoustidis, R Giordano, A Giri, A Glazov, B Gobbo, R Godang, P Goldenzweig, B Golob, W Gradl, E Graziani, D Greenwald, T Gu, Y Guan, K Gudkova, J Guilliams, C Hadjivasiliou, S Halder, K Hara, T Hara, O Hartbrich, K Hayasaka, H Hayashii, S Hazra, C Hearty, I Heredia de la Cruz, M Hernández Villanueva, A Hershenhorn, T Higuchi, E C Hill, H Hirata, M Hoek, M Hohmann, C-L Hsu, T Humair, T Iijima, K Inami, G Inguglia, A Ishikawa, R Itoh, M Iwasaki, Y Iwasaki, W W Jacobs, D E Jaffe, E-J Jang, S Jia, Y Jin, H Junkerkalefeld, H Kakuno, A B Kaliyar, J Kandra, K H Kang, R Karl, G Karyan, Y Kato, T Kawasaki, C Kiesling, C-H Kim, D Y Kim, Y-K Kim, Y Kim, T D Kimmel, K Kinoshita, P Kodyš, T Koga, S Kohani, T Konno, S Korpar, E Kovalenko, R Kowalewski, T M G Kraetzschmar, F Krinner, P Križan, P Krokovny, T Kuhr, J Kumar, M Kumar, R Kumar, K Kumara, S Kurz, A Kuzmin, Y-J Kwon, S Lacaprara, K Lalwani, T Lam, L Lanceri, J S Lange, M Laurenza, K Lautenbach, F R Le Diberder, S C Lee, P Leitl, D Levit, C Li, L K Li, J Libby, K Lieret, Z Liptak, Q Y Liu, D Liventsev, S Longo, T Lueck, C Lyu, R Manfredi, E Manoni, C Marinas, A Martini, T Matsuda, K Matsuoka, D Matvienko, J A McKenna, F Meier, M Merola, F Metzner, C Miller, K Miyabayashi, R Mizuk, G B Mohanty, N Molina-Gonzalez, H Moon, H-G Moser, M Mrvar, C Murphy, R Mussa, I Nakamura, K R Nakamura, M Nakao, H Nakazawa, Z Natkaniec, A Natochii, G Nazaryan, C Niebuhr, M Niiyama, N K Nisar, S Nishida, K Nishimura, S Ogawa, Y Onishchuk, H Ono, Y Onuki, P Oskin, E R Oxford, H Ozaki, P Pakhlov, A Paladino, T Pang, A Panta, E Paoloni, S Pardi, H Park, S-H Park, B Paschen, A Passeri, A Pathak, S Patra, S Paul, T K Pedlar, I Peruzzi, R Peschke, R Pestotnik, F Pham, M Piccolo, L E Piilonen, G Pinna Angioni, P L M Podesta-Lerma, T Podobnik, S Pokharel, G Polat, V Popov, C Praz, S Prell, E Prencipe, M T Prim, M V Purohit, H Purwar, N Rad, P Rados, S Raiz, S Reiter, M Remnev, I Ripp-Baudot, G Rizzo, L B Rizzuto, S H Robertson, J M Roney, A Rostomyan, N Rout, M Rozanska, D Sahoo, D A Sanders, S Sandilya, A Sangal, L Santelj, Y Sato, V Savinov, B Scavino, J Schueler, C Schwanda, A J Schwartz, Y Seino, A Selce, K Senyo, J Serrano, C Sfienti, J-G Shiu, B Shwartz, A Sibidanov, F Simon, R J Sobie, A Soffer, A Sokolov, E Solovieva, S Spataro, B Spruck, M Starič, S Stefkova, Z S Stottler, R Stroili, J Strube, M Sumihama, W Sutcliffe, S Y Suzuki, H Svidras, M Tabata, M Takizawa, U Tamponi, S Tanaka, K Tanida, H Tanigawa, N Taniguchi, F Tenchini, R Tiwary, D Tonelli, E Torassa, N Toutounji, K Trabelsi, T Tsuboyama, I Ueda, S Uehara, Y Uematsu, T Uglov, K Unger, Y Unno, K Uno, S Uno, P Urquijo, Y Ushiroda, Y V Usov, S E Vahsen, R van Tonder, G S Varner, A Vinokurova, L Vitale, A Vossen, E Waheed, H M Wakeling, E Wang, M-Z Wang, X L Wang, A Warburton, M Watanabe, M Welsch, C Wessel, J Wiechczynski, E Won, X P Xu, B D Yabsley, S Yamada, W Yan, S B Yang, H Ye, J Yelton, J H Yin, K Yoshihara, Y Yusa, L Zani, V Zhilich, Q D Zhou, X Y Zhou, V I Zhukova, R Žlebčík
We report a measurement of the D^{0} and D^{+} lifetimes using D^{0}→K^{-}π^{+} and D^{+}→K^{-}π^{+}π^{+} decays reconstructed in e^{+}e^{-}→cc[over ¯] data recorded by the Belle II experiment at the SuperKEKB asymmetric-energy e^{+}e^{-} collider. The data, collected at center-of-mass energies at or near the ϒ(4S) resonance, correspond to an integrated luminosity of 72 fb^{-1}. The results, τ(D^{0})=410.5±1.1(stat)±0.8(syst) fs and τ(D^{+})=1030.4±4.7(stat)±3.1(syst) fs, are the most precise to date and are consistent with previous determinations...
November 19, 2021: Physical Review Letters
#27
JOURNAL ARTICLE
F Abudinén, I Adachi, K Adamczyk, P Ahlburg, H Aihara, N Akopov, A Aloisio, N Anh Ky, D M Asner, H Atmacan, T Aushev, V Aushev, A Baur, V Babu, S Baehr, P Bambade, Sw Banerjee, S Bansal, J Baudot, J Becker, P K Behera, J V Bennett, E Bernieri, F U Bernlochner, M Bertemes, E Bertholet, M Bessner, S Bettarini, F Bianchi, T Bilka, D Biswas, A Bozek, M Bračko, P Branchini, N Braun, T E Browder, A Budano, S Bussino, M Campajola, L Cao, G Casarosa, C Cecchi, D Červenkov, P Chang, R Cheaib, V Chekelian, C Chen, Y-T Chen, B G Cheon, K Chilikin, K Chirapatpimol, K Cho, S-J Cho, S Choudhury, D Cinabro, L Corona, L M Cremaldi, S Cunliffe, T Czank, F Dattola, E De La Cruz-Burelo, G de Marino, G De Nardo, M De Nuccio, G De Pietro, R de Sangro, M Destefanis, S Dey, A De Yta-Hernandez, A Di Canto, F Di Capua, J Dingfelder, Z Doležal, I Domínguez Jiménez, T V Dong, K Dort, S Dubey, S Duell, G Dujany, S Eidelman, M Eliachevitch, D Epifanov, T Ferber, D Ferlewicz, T Fillinger, G Finocchiaro, S Fiore, A Fodor, F Forti, A Frey, B G Fulsom, N Gabyshev, E Ganiev, M Garcia-Hernandez, A Garmash, V Gaur, A Gaz, A Gellrich, R Giordano, A Giri, A Glazov, B Gobbo, R Godang, P Goldenzweig, B Golob, P Grace, W Gradl, E Graziani, D Greenwald, Y Guan, K Gudkova, C Hadjivasiliou, S Halder, K Hara, O Hartbrich, K Hayasaka, H Hayashii, S Hazra, C Hearty, I Heredia de la Cruz, M Hernández Villanueva, A Hershenhorn, T Higuchi, E C Hill, H Hirata, M Hoek, M Hohmann, C-L Hsu, T Humair, T Iijima, K Inami, G Inguglia, J Irakkathil Jabbar, A Ishikawa, R Itoh, M Iwasaki, Y Iwasaki, P Jackson, W W Jacobs, D E Jaffe, Y Jin, C Joo, H Junkerkalefeld, A B Kaliyar, J Kandra, K H Kang, R Karl, G Karyan, T Kawasaki, C Ketter, H Kichimi, C Kiesling, C-H Kim, D Y Kim, Y-K Kim, T D Kimmel, P Kodyš, T Koga, S Kohani, T Konno, A Korobov, S Korpar, E Kovalenko, T M G Kraetzschmar, F Krinner, P Križan, P Krokovny, T Kuhr, J Kumar, M Kumar, R Kumar, K Kumara, T Kunigo, S Kurz, A Kuzmin, Y-J Kwon, S Lacaprara, Y-T Lai, C La Licata, L Lanceri, J S Lange, M Laurenza, K Lautenbach, F R Le Diberder, S C Lee, P Leitl, D Levit, P M Lewis, C Li, L K Li, S X Li, Y B Li, J Libby, K Lieret, Z Liptak, Q Y Liu, D Liventsev, S Longo, A Lozar, T Lueck, C Lyu, M Maggiora, S Maity, R Manfredi, E Manoni, S Marcello, C Marinas, A Martini, M Masuda, T Matsuda, K Matsuoka, D Matvienko, F Meier, M Merola, F Metzner, M Milesi, C Miller, K Miyabayashi, H Miyake, R Mizuk, G B Mohanty, H-G Moser, M Mrvar, F J Müller, C Murphy, R Mussa, K R Nakamura, M Nakao, Z Natkaniec, A Natochii, M Nayak, G Nazaryan, C Niebuhr, N K Nisar, S Nishida, K Nishimura, S Ogawa, Y Onishchuk, H Ono, Y Onuki, P Oskin, H Ozaki, P Pakhlov, G Pakhlova, A Paladino, T Pang, A Panta, E Paoloni, S Pardi, H Park, S-H Park, B Paschen, A Passeri, A Pathak, S Patra, S Paul, T K Pedlar, I Peruzzi, R Pestotnik, M Piccolo, L E Piilonen, P L M Podesta-Lerma, T Podobnik, S Pokharel, G Polat, V Popov, C Praz, S Prell, E Prencipe, M T Prim, N Rad, P Rados, S Raiz, M Remnev, I Ripp-Baudot, M Ritter, G Rizzo, L B Rizzuto, S H Robertson, D Rodríguez Pérez, J M Roney, A Rostomyan, N Rout, G Russo, D Sahoo, D A Sanders, S Sandilya, A Sangal, L Santelj, Y Sato, V Savinov, B Scavino, J Schueler, C Schwanda, A J Schwartz, R M Seddon, Y Seino, A Selce, K Senyo, J Serrano, M E Sevior, C Sfienti, J-G Shiu, B Shwartz, A Sibidanov, F Simon, R J Sobie, A Soffer, A Sokolov, E Solovieva, S Spataro, B Spruck, M Starič, S Stefkova, Z S Stottler, R Stroili, M Sumihama, K Sumisawa, D J Summers, W Sutcliffe, S Y Suzuki, H Svidras, M Tabata, M Takahashi, M Takizawa, U Tamponi, S Tanaka, K Tanida, H Tanigawa, N Taniguchi, P Taras, F Tenchini, D Tonelli, E Torassa, N Toutounji, K Trabelsi, M Uchida, Y Unno, K Uno, S Uno, P Urquijo, Y Ushiroda, Y V Usov, S E Vahsen, R van Tonder, G S Varner, K E Varvell, A Vinokurova, L Vitale, B Wach, E Waheed, H M Wakeling, W Wan Abdullah, M-Z Wang, X L Wang, A Warburton, S Watanuki, J Webb, M Welsch, C Wessel, J Wiechczynski, H Windel, X P Xu, B D Yabsley, S Yamada, W Yan, S B Yang, H Ye, J Yelton, J H Yin, Y M Yook, K Yoshihara, C Z Yuan, Y Yusa, L Zani, V Zhilich, Q D Zhou, X Y Zhou, V I Zhukova
A search for the flavor-changing neutral-current decay B^{+}→K^{+}νν[over ¯] is performed at the Belle II experiment at the SuperKEKB asymmetric energy electron-positron collider. The data sample corresponds to an integrated luminosity of 63 fb^{-1} collected at the ϒ(4S) resonance and a sample of 9 fb^{-1} collected at an energy 60 MeV below the resonance. Because the measurable decay signature involves only a single charged kaon, a novel measurement approach is used that exploits not only the properties of the B^{+}→K^{+}νν[over ¯] decay, but also the inclusive properties of the other B meson in the ϒ(4S)→BB[over ¯] event, to suppress the background from other B meson decays and light-quark pair production...
October 29, 2021: Physical Review Letters
#28
JOURNAL ARTICLE
Stefan Lautenbacher, Annegret Hoos, Göran Hajak, Wolfgang Trapp, Miriam Kunz
It is well established that individuals with cognitive impairment present with disturbed forms of pain processing of still unknown origin. As a neurocognitive factor, executive functions have become favored candidates for explanation. For further insights, we aimed at comparing executive functions and memory in their association with parameters indicating onset and escalation of pain perception. Subjective ratings of experimentally induced pressure pain applied in ascending series were assessed in older individuals with (N = 32) and without mild cognitive impairments (MCI) (N = 32)...
October 4, 2021: Brain Sciences
#29
JOURNAL ARTICLE
Claudia Horn-Hofmann, Jennifer J Piloth, Astrid Schütz, Roy F Baumeister, Stefan Lautenbacher
OBJECTIVES: Past work has found that optimism reduces a person's responsiveness to pain, but the effects of pessimism are not clear. Therefore, we gave pessimistic forecasts of participants' future social life and measured changes in their pain responsiveness. In particular, some participants were told that they would end up alone in life. METHODS: Seventy-five subjects were investigated in three conditions (negative forecast, positive forecast, no forecast) for changes in pain threshold and pain tolerance threshold...
April 26, 2022: Scandinavian Journal of Pain
#30
JOURNAL ARTICLE
Karsten Hollmann, Katharina Allgaier, Carolin S Hohnecker, Heinrich Lautenbacher, Verena Bizu, Matthias Nickola, Gunilla Wewetzer, Christoph Wewetzer, Tord Ivarsson, Norbert Skokauskas, Lidewij H Wolters, Gudmundur Skarphedinsson, Bernhard Weidle, Else de Haan, Nor Christan Torp, Scott N Compton, Rosa Calvo, Sara Lera-Miguel, Anna Haigis, Tobias J Renner, Annette Conzelmann
Cognitive behavioral therapy (CBT) is the first choice of treatment of obsessive-compulsive disorder (OCD) in children and adolescents. However, there is often a lack of access to appropriate treatment close to the home of the patients. An internet-based CBT via videoconferencing could facilitate access to state-of-the-art treatment even in remote areas. The aim of this study was to investigate feasibility and acceptability of this telemedical approach. A total of nine children received 14 sessions of CBT. The first session took place face-to-face, the remaining 13 sessions via videoconference...
August 25, 2021: Journal of Neural Transmission
#31
JOURNAL ARTICLE
James J Harrigan, Hatem Abdallah, Erik L Clarke, Arman Oganisian, Jason A Roy, Ebbing Lautenbach, Emily Reesey, Magda Wernovsky, Pam Tolomeo, Zygmunt Morawski, Jerry Jacob, Michael A Grippi, Brendan J Kelly
BACKGROUND: Ventilator-associated lower respiratory tract infection (VA-LRTI) is a common among critically ill patients and has been associated with increased morbidity and mortality. In acute critical illness, respiratory microbiome disruption indices (MDIs) have been shown to predict risk for VA-LRTI, but their utility beyond the first days of critical illness is unknown. We sought to characterize how MDIs previously shown to predict VA-LRTI at initiation of mechanical ventilation change with prolonged mechanical ventilation, and if they remain associated with VA-LRTI risk...
August 7, 2021: Clinical Infectious Diseases
#32
RANDOMIZED CONTROLLED TRIAL
Lauren Dutcher, Kathleen Degnan, Afia B Adu-Gyamfi, Ebbing Lautenbach, Leigh Cressman, Michael Z David, Valerie Cluzet, Julia E Szymczak, David A Pegues, Warren Bilker, Pam Tolomeo, Keith W Hamilton
BACKGROUND: Inappropriate antibiotic prescribing is common in primary care (PC), particularly for respiratory tract diagnoses (RTDs). However, the optimal approach for improving prescribing remains unknown. METHODS: We conducted a stepped-wedge study in PC practices within a health system to assess the impact of a provider-targeted intervention on antibiotic prescribing for RTDs. RTDs were grouped into tiers based on appropriateness of antibiotic prescribing: tier 1 (almost always indicated), tier 2 (may be indicated), and tier 3 (rarely indicated)...
March 23, 2022: Clinical Infectious Diseases
#33
JOURNAL ARTICLE
Sascha Leisterer, Franziska Lautenbach, Nadja Walter, Lara Kronenberg, Anne-Marie Elbe
The COVID-19 pandemic is also called a crisis of uncertainty because of so many unforeseeable events like canceled qualification competitions, loss of training facilities, and postponement of the Olympic games. Athletes and their entourage experience this uncertainty as stressful. Sport psychology practitioners (SPPs) are in a key position to support athletes in coping with these unforeseeable stressors. However, SPPs are similarly affected by the COVID-19 pandemic and simultaneously have to cope with stress...
2021: Frontiers in Psychology
#34
JOURNAL ARTICLE
Janosch A Priebe, Claudia Horn-Hofmann, Daniel Wolf, Stefanie Wolff, Michael Heesen, Katrin Knippenberg-Bigge, Philip Lang, Stefan Lautenbacher
Altered attentional processing of pain-associated stimuli-which might take the form of either avoidance or enhanced vigilance-is thought to be implicated in the development and maintenance of chronic pain. In contrast to reaction time tasks like the dot probe, eye tracking allows for tracking the time course of visual attention and thus differentiating early and late attentional processes. Our study aimed at investigating visual attention to emotional faces in patients with chronic musculoskeletal pain (N = 20) and matched pain-free controls (N = 20)...
2021: PloS One
#35
JOURNAL ARTICLE
Eleonora Meister, Claudia Horn-Hofmann, Miriam Kunz, Eva G Krumhuber, Stefan Lautenbacher
OBJECTIVES: The decoding of facial expressions of pain plays a crucial role in pain diagnostic and clinical decision making. For decoding studies, it is necessary to present facial expressions of pain in a flexible and controllable fashion. Computer models (avatars) of human facial expressions of pain allow for systematically manipulating specific facial features. The aim of the present study was to investigate whether avatars can show realistic facial expressions of pain and how the sex of the avatars influence the decoding of pain by human observers...
January 27, 2021: Scandinavian Journal of Pain
#36
JOURNAL ARTICLE
Richard E Nelson, Ebbing Lautenbach, Nelson Chang, Makoto Jones, Tina Willson, Michael David, Darren Linkin, Henry Glick, Jalpa A Doshi, Vanessa W Stevens
BACKGROUND: Studies have shown that healthcare-associated infections (HAIs) due to methicillin-resistant Staphylococcus aureus (MRSA) can lead to substantial healthcare costs in acute care settings. However, little is known regarding the consequences of these infections on patients in long-term care centers (LTCCs). The purpose of this study was to estimate the attributable cost of MRSA HAIs in LTCCs within the Department of Veterans Affairs (VA). METHODS: We performed a retrospective cohort study of patients admitted to VA LTCCs between 1 January 2009 and 30 September 2015...
January 29, 2021: Clinical Infectious Diseases
#37
JOURNAL ARTICLE
Caroline Rönnberg, Allan Lugaajju, Anna Nyman, Ulf Hammar, Matteo Bottai, Maximilian Julius Lautenbach, Christopher Sundling, Fred Kironde, Kristina E M Persson
Malaria is a potentially life-threatening disease with approximately half of the world's population at risk. Young children and pregnant women are hit hardest by the disease. B cells and antibodies are part of an adaptive immune response protecting individuals continuously exposed to the parasite. An infection with Plasmodium falciparum can cause dysregulation of B cell homeostasis, while antibodies are known to be key in controlling symptoms and parasitemia. BAFF is an instrumental cytokine for the development and maintenance of B cells...
2021: PloS One
#38
JOURNAL ARTICLE
Kelly A Cawcutt, Robin Patel, Jeff Gerber, Angela M Caliendo, Sara E Cosgrove, Elizabeth Dodds Ashley, Piero Garzaro, Melissa Miller, Ebbing Lautenbach
Respiratory tract infections (RTIs) drive many outpatient encounters and, despite being predominantly viral, are associated with high rates of antibiotic prescriptions. With rising antibacterial resistance, optimization of prescribing of antibiotics in outpatients with RTIs is a critical need. Fortunately, this challenge arises at a time of increasing availability of novel RTI diagnostics to help discern which patients have bacterial infections warranting treatment. Effective implementation of antibiotic stewardship is needed, but optimal approaches for ambulatory settings are unknown...
June 15, 2021: Clinical Infectious Diseases
#39
REVIEW
Susan E Coffin, Francisca Abanyie, Kristina Bryant, Joseph Cantey, Anthony Fiore, Stephanie Fritz, Judith Guzman-Cottrill, Adam L Hersh, W Charles Huskins, Larry K Kociolek, Matthew Kronman, Ebbing Lautenbach, Grace Lee, Matthew Linam, Latania K Logan, Aaron Milstone, Jason Newland, A Christine Nyquist, Debra L Palazzi, Sameer Patel, Karen Puopolo, Sujan C Reddy, Lisa Saiman, Thomas Sandora, Andi L Shane, Michael Smith, Pranita D Tamma, Theoklis Zaoutis, Danielle Zerr, Jeffrey S Gerber
OBJECTIVE: To develop a pediatric research agenda focused on pediatric healthcare-associated infections and antimicrobial stewardship topics that will yield the highest impact on child health. PARTICIPANTS: The study included 26 geographically diverse adult and pediatric infectious diseases clinicians with expertise in healthcare-associated infection prevention and/or antimicrobial stewardship (topic identification and ranking of priorities), as well as members of the Division of Healthcare Quality and Promotion at the Centers for Disease Control and Prevention (topic identification)...
May 2021: Infection Control and Hospital Epidemiology
#40
JOURNAL ARTICLE
Miriam Kunz, Kenneth Prkachin, Patricia E Solomon, Stefan Lautenbacher
BACKGROUND: Facial activity during pain is composed of varying combinations of a few elementary facial responses (so-called Action Units). A previous study of experimental pain showed that these varying combinations can be clustered into distinct facial activity patterns of pain. In the present study, we examined whether comparable facial activity patterns can also be identified among people suffering from clinical pain; namely, shoulder pain. METHODS: Facial expressions of patients suffering from shoulder pain (N = 126) were recorded while twice undergoing a battery of passive range-of-motion tests to their affected limbs (UNBC-McMaster Shoulder Pain Expression Archive Database), which elicited peaks of acute pain...
March 2021: European Journal of Pain: EJP
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