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Bilateral optic neuritis

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https://www.readbyqxmd.com/read/29731712/baseline-brain-activity-changes-in-patients-with-single-and-relapsing-optic-neuritis
#1
Zhuoqiong Ren, Yaou Liu, Kuncheng Li, Yunyun Duan, Huang Jing, Peipeng Liang, Zheng Sun, Xiaojun Zhang, Bei Mao
Purpose : To investigate spontaneous brain activity amplitude alterations in single and relapsing optic neuritis (sON and rON, respectively) and their relationships with clinical variables. Methods : In total, 42 patients with sON, 35 patients with rON and 50 healthy volunteers were recruited. Resting-state functional Magnetic Resonance Imaging (rs-fMRI) scans were acquired for all participants and compared to investigate the changes in the amplitude of low-frequency fluctuations (ALFFs) among the three groups...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29682349/multiple-sclerosis-patients-with-markedly-low-intrathecal-antibody-response-in-sri-lanka
#2
S M K Gamage, I Wijeweera, S B Adikari, Katharina Fink, Jan Hillert, Anna Fogdell-Hahn, H M A Sominanda
Multiple sclerosis (MS) is a heterogeneous disease which is poorly studied in Asia, where the disease is known to be rare with significant differences in clinical and radiological presentations and intrathecal antibody response. Therefore the objective of this study was to determine clinical presentation, radiological and neurophysiological characteristics, and oligoclonal band status in Sri Lankan MS patients, following careful exclusion of patients with neuromyelitis optica spectrum disorders and other conditions mimicking multiple sclerosis...
2018: Multiple Sclerosis International
https://www.readbyqxmd.com/read/29676196/contiguous-and-symmetrical-disease-expansion-and-massive-necrosis-of-the-cerebral-white-matter-in-a-patient-with-neuromyelitis-optica
#3
Chiho Ishida, Tokuhei Ikeda, Kiyonobu Komai, Kazuya Takahashi, Moeko Noguchi-Shinohara, Masahito Yamada
The present report discusses the case of a woman with neuromyelitis optica (NMO) who exhibited bilateral optic neuritis, longitudinally extensive myelitis, serum anti-aquaporin-4 antibodies, and a unique pattern of white matter involvement. The disease duration was 26 years, and the patient died at the age of 65 years. Sequential magnetic resonance images obtained during the last 6 years of life revealed leukoencephalopathy-like lesions extending symmetrically and contiguously from the periventricular regions, which had begun to transform into multiple cavities with semi-annular partitions...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29625838/suppression-of-melatonin-secretion-in-totally-visually-blind-people-by-ocular-exposure-to-white-light-clinical-characteristics
#4
Joseph T Hull, Charles A Czeisler, Steven W Lockley
PURPOSE: Although most totally visually blind individuals exhibit nonentrained circadian rhythms due to an inability of light to entrain the circadian pacemaker, a small proportion retain photic circadian entrainment, melatonin suppression, and other nonimage-forming responses to light. It is thought that these responses to light persist because of the survival of melanospin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), which project primarily to the circadian pacemaker and are functionally distinct from the rod and cone photoreceptors that mediate vision...
April 3, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29615180/a-case-of-vogt-koyanagi-harada-syndrome-mimicking-optic-neuritis
#5
Muhammad Mateen Amir, Atif Masood, Zarmina Khan
Vogt-Koyanagi-Harada syndrome is a rare disease that occurs commonly in pigmented individuals of Asian origin. A 25-year female presented in medical outpatient department (OPD) of Al-Khidmat Teaching Hospital, Mansoora, Lahore with headache and neck stiffness. She was referred to eye OPD for the complaint of decreased vision. On examination, there was 6/24 vision, sluggish pupillary reaction and disc hyperemia in both eyes. She was treated as a case of optic neuritis. Few days later, she developed bilateral panuveitis, shallow exudative detachments and alopecia...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29571874/identification-and-treatment-of-the-visual-processing-asymmetry-in-ms-patients-with-optic-neuritis-the-pulfrich-phenomenon
#6
Millad J Sobhanian, Rohit Agarwal, Ethan Meltzer, Eric Kildebeck, Benjamin S Frohman, Ashley N Frohman, Steven L Galetta, Shiv Saidha, Owen White, Pablo Villoslada, Friedemann Paul, Axel Petzold, Robert L Rennaker, Elena H Martinez-Lapiscina, Laura J Balcer, Randy Kardon, Elliot M Frohman, Teresa C Frohman
BACKGROUND: The Pulfrich phenomenon (PF) is the illusory perception that an object moving linearly along a 2-D plane appears to instead follow an elliptical 3-D trajectory, a consequence of inter-eye asymmetry in the timing of visual object identification in the visual cortex; with optic neuritis as a common etiology. OBJECTIVE: We have designed an objective method to identify the presence and magnitude of the PF, in conjunction with a cooresponding strategy by which to abolish the effect; with monocular application of neutral density filters to the less affected fellow eye, in patients with MS and a history of optic neuropathy (e...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29563955/atypical-optic-neuritis-after-inactivated-influenza-vaccination
#7
Bokkwan Jun, Frederick W Fraunfelder
The existence of vaccine-associated optic neuritis is essentially based on the temporal relationship between the administration of a vaccine and the development of optic neuritis in patients with no other known aetiologies for infectious or non-infectious inflammation that could account for the optic neuritis. Influenza vaccine (inactivated or live attenuated) is considered to be one of vaccines that could be related to optic neuritis. The authors describe a rare case of bilateral asymmetric optic neuritis with leptomeningeal enhancement on magnetic resonance imaging (MRI) in a previously healthy young woman who received inactivated influenza vaccination 2 weeks before the onset of symptoms...
April 2018: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29554001/visual-outcomes-and-clinical-manifestations-of-pediatric-optic-neuritis-in-indian-population-an-institutional-study
#8
Selvakumar Ambika, Krishnakumar Padmalakshmi, Viswanathan Venkatraman, Olma V Noronha
BACKGROUND: Optic neuritis in children is an uncommon disorder which usually occurs after a viral illness or vaccination and, less frequently, occurs as a manifestation of a demyelinating disorder. Pediatric optic neuritis usually is bilateral and presents with optic disc edema, recovers rapidly with steroid therapy, and generally has low conversion rate to multiple sclerosis or neuromyelitis optica spectrum disorder. We report the clinical features and treatment outcomes of pediatric optic neuritis in Indian population, for which little data are available...
March 16, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29526320/optic-neuritis-in-paediatric-patients-experience-over-27-years-and-a-management-protocol
#9
L Monge Galindo, A L Martínez de Morentín, V Pueyo Royo, J P García Iñiguez, S Sánchez Marco, J López-Pisón, J L Peña-Segura
INTRODUCTION AND OBJECTIVE: In this article, we present our experience on optic neuritis (ON) and provide a diagnostic/therapeutic protocol, intended to rule out other aetiologies (particularly infection), and a fact sheet for parents. MATERIAL AND METHODS: We conducted a descriptive, retrospective study of patients with ON over a 27-year period (1990-2017). A review of the available scientific evidence was performed in order to draft the protocol and fact sheet...
March 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29429558/guillain-barr%C3%A3-syndrome-and-optic-neuritis-after-mycoplasma-pneumoniae-infection
#10
Manaka Matsunaga, Yuichi Kodama, Shinsuke Maruyama, Akinori Miyazono, Shunji Seki, Takayuki Tanabe, Michiyoshi Yoshimura, Junichiro Nishi, Yoshifumi Kawano
We report the case of a 12-year-old girl who developed Guillain-Barré syndrome (GBS) and optic neuritis (ON) following Mycoplasma pneumoniae infection. Her symptoms, including bilateral vision impairment and tingling in her hands and right foot, were resolved after methylprednisolone pulse therapy. Serum anti-galactocerebroside (Gal-C) IgM antibodies were detected in our patient. This is the first report of a child with GBS and ON associated with M. pneumoniae infection.
May 2018: Brain & Development
https://www.readbyqxmd.com/read/29392642/impairment-of-acquired-color-vision-in-multiple-sclerosis-an-early-diagnostic-sign-linked-to-the-greatness-of-disease
#11
Anna Piro, Antonio Tagarelli, Giuseppe Nicoletti, Sara Scannapieco, Serena Polidoro, Paola Valentino, Aldo Quattrone
OBJECTIVE: To assess the type and degree of both red-green and blue-yellow color vision deficiencies of Calabrian males affected by multiple sclerosis. MATERIAL: Eighty Calabrian male patients were enrolled (age range 18-70 years; mean age 40.6 ± 12.4 years) showing a disease duration mean of 10.6 ± 8.2 years (range = 0.5-46 years) coming from the Institute of Neurology, Magna Graecia University, Catanzaro. Optic neuritis present in the medical histories of the 21 patients does not influence color vision...
February 1, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29305439/optic-nerve-head-edema-among-patients-presenting-to-the-emergency-department
#12
Virender Sachdeva, Caroline Vasseneix, Rabih Hage, Samuel Bidot, Lindsay C Clough, David W Wright, Nancy J Newman, Valérie Biousse, Beau B Bruce
OBJECTIVE: To determine the frequency of and predictive factors for optic nerve head edema (ONHE) among patients with headache, neurologic deficit, visual loss, or elevated blood pressure in the emergency department (ED). METHODS: Cross-sectional analysis was done of patients with ONHE in the prospective Fundus Photography vs Ophthalmoscopy Trial Outcomes in the Emergency Department (FOTO-ED) study. Demographics, neuroimaging results, management, and patient disposition were collected...
January 30, 2018: Neurology
https://www.readbyqxmd.com/read/29288492/-leukodystrophy-like-phenotype-in-children-with-myelin-oligodendrocyte-glycoprotein-antibody-associated-disease
#13
Yael Hacohen, Thomas Rossor, Kshitij Mankad, Wk 'Kling' Chong, Andrew Lux, Evangeline Wassmer, Ming Lim, Frederik Barkhof, Olga Ciccarelli, Cheryl Hemingway
AIM: To review the demographics and clinical and paraclinical parameters of children with myelin oligodendrocyte glycoprotein (MOG) antibody-associated relapsing disease. METHOD: In this UK-based, multicentre study, 31 children with MOG antibody-associated relapsing disease were studied retrospectively. RESULTS: Of the 31 children studied, 14 presented with acute disseminated encephalomyelitis (ADEM); they were younger (mean 4.1y) than the remainder (mean 8...
April 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29251394/optic-neuritis-in-dogs-96-cases-1983-2016
#14
Sara M Smith, Hans D Westermeyer, Christopher L Mariani, Brian C Gilger, Michael G Davidson
OBJECTIVE: To characterize ocular and neurologic findings, causes, and treatment outcomes of dogs with optic neuritis. PROCEDURE: Medical records from dogs with a diagnosis of optic neuritis at North Carolina State University, College of Veterinary Medicine, Veterinary Hospital between 1983 and 2016 were reviewed. RESULTS: Ninety-six cases (20 unilateral, 76 bilateral), comprised of 38 males and 58 females with a mean age of 6.1 ± 3.0 years (range 0...
December 18, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29201326/a-challenging-entity-multiple-sclerosis-or-collagen-tissue-disorders-a-case-series-of-6-patients
#15
Raida Ben Salah, Yosra Cherif, Faten Frikha, Dammak Chifaa, Mouna Snoussi, Moez Jallouli, Sameh Marzouk, Mhiri Chokri, Zouhir Bahloul
Background: Multiple sclerosis and other demyelinating processes are sometimes difficult to differentiate from the neurological involvement in autoimmune diseases. Distinguishing multiple sclerosis from other lesions due to autoimmune diseases is crucial to avoid unsuitable or delayed treatments. Methods: Charts of 6 patients diagnosed with mimicking multiple sclerosis between 1996 and 2014 were retrospectively assessed. Results: The mean age at diagnosis was 35±7 years...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29166635/the-protean-neuropsychiatric-and-vestibuloauditory-manifestations-of-neurosarcoidosis
#16
Jacqueline J Greene, Ilka C Naumann, Janet M Poulik, Kevin T Nella, Lindsay Weberling, Jeffrey P Harris, Akihiro J Matsuoka
BACKGROUND: A rare subset of sarcoidosis, neurosarcoidosis, is reported to occur in 5-7% of sarcoid patients and can manifest in a variety of ways. The most common are facial paralysis and optic neuritis, less commonly causing cochleovestibulopathy, blindness, anosmia, and other cranial nerve (CN) palsies. The sensory deficit may be severe and psychiatric symptoms may result from the effects of the disease or steroid treatment. Although MRI-compatible cochlear implants are now available, concerns about the feasibility of recoverable hearing with cochlear implantation in these patients as well as the practical difficulty of disease monitoring due to implant artifact must be considered...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29166458/mog-igg-associated-optic-neuritis-is-not-multiple-sclerosis
#17
COMPARATIVE STUDY
Bruna Klein da Costa, Giordani Rodrigues Dos Passos, Jefferson Becker, Douglas Kazutoshi Sato
Autoantibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with inflammatory central nervous system disorders including isolated optic neuritis (ON). We compared our MOG-IgG ON patients with multiple sclerosis (MS) patients presenting with ON. METHODS AND RESULTS: Among the total of 38 patients with optic neuropathies, six patients with isolated ON were MOG-IgG positive and eight patients with ON fulfilled the diagnostic criteria for MS. All MS patients were negative for MOG-IgG using a cell-based assay...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29142145/clinical-course-therapeutic-responses-and-outcomes-in-relapsing-mog-antibody-associated-demyelination
#18
Sudarshini Ramanathan, Shekeeb Mohammad, Esther Tantsis, Tina Kim Nguyen, Vera Merheb, Victor S C Fung, Owen Bruce White, Simon Broadley, Jeannette Lechner-Scott, Steve Vucic, Andrew P D Henderson, Michael Harry Barnett, Stephen W Reddel, Fabienne Brilot, Russell C Dale
OBJECTIVE: We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination. METHODS: We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients. RESULTS: The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children...
February 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29136091/clinical-presentation-and-prognosis-in-mog-antibody-disease-a-uk-study
#19
Maciej Jurynczyk, Silvia Messina, Mark R Woodhall, Naheed Raza, Rosie Everett, Adriana Roca-Fernandez, George Tackley, Shahd Hamid, Angela Sheard, Gavin Reynolds, Saleel Chandratre, Cheryl Hemingway, Anu Jacob, Angela Vincent, M Isabel Leite, Patrick Waters, Jacqueline Palace
No abstract text is available yet for this article.
December 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29055448/a-case-of-mog-antibody-positive-bilateral-optic-neuritis-and-meningoganglionitis-following-a-genital-herpes-simplex-virus-infection
#20
Masataka Nakamura, Yuko Iwasaki, Toshiyuki Takahashi, Kimihiko Kaneko, Ichiro Nakashima, Takenobu Kunieda, Satoshi Kaneko, Hirofumi Kusaka
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) antibody-positive optic neuritis (ON) and myelitis are recognized as important differential diagnosis of aquaporin-4 (AQP4) antibody-positive neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD). Similar to NMO/NMOSD associated with AQP4 antibodies, preceding infections have been reported in patients with MOG antibody-positive ON. This is the first report of bilateral ON following a herpes simplex virus (HSV) infection associated with a positive MOG antibody...
October 2017: Multiple Sclerosis and related Disorders
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