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https://www.readbyqxmd.com/read/27896895/five-year-efficacy-and-safety-of-tenofovir-based-salvage-therapy-for-patients-with-chronic-hepatitis-b-who-previously-failed-lam-adv-therapy
#1
Lucy Lim, Alexander Thompson, Scott Patterson, Jacob George, Simone Strasser, Alice Lee, William Sievert, Amanda Nicoll, Paul Desmond, Stuart Roberts, Kaye Marion, Scott Bowden, Stephen Locarnini, Peter Angus
BACKGROUND: Multidrug resistant HBV continues to be an important clinical problem. The TDF-109 study demonstrated that TDF±LAM is effective salvage therapy through 96 weeks for LAM resistant patients who previously failed ADV add-on or switch therapy. We evaluated the 5 year efficacy and safety outcomes in patients receiving long-term TDF±LAM in the TDF-109 study. METHODS: 59 patients completed the first phase of the TDF-109 study and 54/59 were rolled over into a long-term prospective open-label study of TDF±LAM 300mg daily...
November 29, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27821112/power-fairness-and-trust-understanding-and-engaging-with-vaccine-trial-participants-and-communities-in-the-setting-up-the-ebovac-salone-vaccine-trial-in-sierra-leone
#2
Luisa Enria, Shelley Lees, Elizabeth Smout, Thomas Mooney, Angus F Tengbeh, Bailah Leigh, Brian Greenwood, Deborah Watson-Jones, Heidi Larson
BACKGROUND: This paper discusses the establishment of a clinical trial of an Ebola vaccine candidate in Kambia District, Northern Sierra Leone during the epidemic, and analyses the role of social science research in ensuring that lessons from the socio-political context, the recent experience of the Ebola outbreak, and learning from previous clinical trials were incorporated in the development of community engagement strategies. The paper aims to provide a case study of an integrated social science and communications system in the start-up phase of the clinical trial...
November 8, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27810451/surgical-outcome-for-moyamoya-disease-clinical-and-perfusion-computed-tomography-correlation
#3
Alvin Ho-Kwan Cheung, Angus Ka-Cheong Lam, Wai-Shing Wilson Ho, Chun-Pong Tsang, Anderson Chun-On Tsang, Raymond Lee, Wai-Man Lui, Gilberto Ka-Kit Leung
No abstract text is available yet for this article.
October 31, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27640093/evolutionary-analyses-of-hanwoo-korean-cattle-specific-single-nucleotide-polymorphisms-and-genes-using-whole-genome-resequencing-data-of-a-hanwoo-population
#4
Daehwan Lee, Minah Cho, Woon-Young Hong, Dajeong Lim, Hyung-Chul Kim, Yong-Min Cho, Jin-Young Jeong, Bong-Hwan Choi, Younhee Ko, Jaebum Kim
Advances in next generation sequencing (NGS) technologies have enabled population-level studies for many animals to unravel the relationships between genotypic differences and traits of specific populations. The objective of this study was to perform evolutionary analysis of single nucleotide polymorphisms (SNP) in genes of Korean native cattle Hanwoo in comparison to SNP data from four other cattle breeds (Jersey, Simmental, Angus, and Holstein) and four related species (pig, horse, human, and mouse) obtained from public databases through NGS-based resequencing...
September 2016: Molecules and Cells
https://www.readbyqxmd.com/read/27509052/modelling-the-structure-and-dynamics-of-biological-pathways
#5
Laura O'Hara, Alessandra Livigni, Thanos Theo, Benjamin Boyer, Tim Angus, Derek Wright, Sz-Hau Chen, Sobia Raza, Mark W Barnett, Paul Digard, Lee B Smith, Tom C Freeman
There is a need for formalised diagrams that both summarise current biological pathway knowledge and support modelling approaches that explain and predict their behaviour. Here, we present a new, freely available modelling framework that includes a biologist-friendly pathway modelling language (mEPN), a simple but sophisticated method to support model parameterisation using available biological information; a stochastic flow algorithm that simulates the dynamics of pathway activity; and a 3-D visualisation engine that aids understanding of the complexities of a system's dynamics...
August 2016: PLoS Biology
https://www.readbyqxmd.com/read/27489380/efficacy-and-tolerability-of-paliperidone-extended-release-in-the-treatment-of-first-episode-psychosis-an-eight-week-open-label-multicenter-trial
#6
Nam-In Kang, Bon-Hoon Koo, Sung-Wan Kim, Jong-Hoon Kim, Beomwoo Nam, Bong-Ju Lee, Sang-Hyuk Lee, Seung Jae Lee, Seung-Hwan Lee, Myung Hun Jung, Sang Woo Hahn, Young-Chul Chung
OBJECTIVE: We investigated the efficacy and tolerability of paliperidone extended-release (ER) tablets in patients with first-episode psychosis (n=75). METHODS: This was an 8-week, open-label, multicenter trial. The primary outcome variable was scores on the Positive and Negative Syndrome Scale (PANSS); secondary measures included the Scale for the Assessment of Negative Symptoms (SANS), the Cognitive Assessment Interview (CAI), and the Global Assessment of Functioning (GAF)...
August 31, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27440289/hello-harlie-enabling-speech-monitoring-through-chat-bot-conversations
#7
David Ireland, Christina Atay, Jacki Liddle, Dana Bradford, Helen Lee, Olivia Rushin, Thomas Mullins, Dan Angus, Janet Wiles, Simon McBride, Adam Vogel
People with neurological conditions such as Parkinson's disease and dementia are known to have difficulties in language and communication. This paper presents initial testing of an artificial conversational agent, called Harlie. Harlie runs on a smartphone and is able to converse with the user on a variety of topics. A description of the application and a sample dialog are provided to illustrate the various roles chat-bots can play in the management of neurological conditions. Harlie can be used for measuring voice and communication outcomes during the daily life of the user, and for gaining information about challenges encountered...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27367804/severe-intrapartum-asphyxia-from-subamniotic-hemorrhage
#8
Tsz-Kin Lo, Andrea Lee, Wan-Pang Chan, Sze-Ki Hui, Yu-Ming Fu, Chi-Chiu Shek, Angus Lam
Subamniotic hemorrhage results from rupture of chorionic vessels near the cord insertion. In the literature, it has never been a major cause for severe intrapartum complications. We report the first case of acute massive subamniotic hemorrhage intrapartum resulting in severe perinatal asphyxia.
2016: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/27165278/continuity-of-care
#9
Denis Pereira Gray, Kate Sidaway-Lee, Angus Thorne, Eleanor White, Philip Evans
No abstract text is available yet for this article.
May 2016: Education for Primary Care
https://www.readbyqxmd.com/read/27151215/highly-efficient-mouse-genome-editing-by-crispr-ribonucleoprotein-electroporation-of-zygotes
#10
Sean Chen, Benjamin Lee, Angus Yiu-Fai Lee, Andrew J Modzelewski, Lin He
The CRISPR/Cas9 system has been employed to efficiently edit the genomes of diverse model organisms. CRISPR-mediated mouse genome editing is typically accomplished by microinjection of Cas9 DNA/RNA and single guide RNA (sgRNA) into zygotes to generate modified animals in one step. However, microinjection is a technically demanding, labor-intensive, and costly procedure with poor embryo viability. Here, we describe a simple and economic electroporation-based strategy to deliver Cas9/sgRNA ribonucleoproteins into mouse zygotes with 100% efficiency for in vivo genome editing...
July 8, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27110679/a-small-molecule-mitigates-hearing-loss-in-a-mouse-model-of-usher-syndrome-iii
#11
Kumar N Alagramam, Suhasini R Gopal, Ruishuang Geng, Daniel H-C Chen, Ina Nemet, Richard Lee, Guilian Tian, Masaru Miyagi, Karine F Malagu, Christopher J Lock, William R K Esmieu, Andrew P Owens, Nicola A Lindsay, Krista Ouwehand, Faywell Albertus, David F Fischer, Roland W Bürli, Angus M MacLeod, William E Harte, Krzysztof Palczewski, Yoshikazu Imanishi
Usher syndrome type III (USH3), characterized by progressive deafness, variable balance disorder and blindness, is caused by destabilizing mutations in the gene encoding the clarin-1 (CLRN1) protein. Here we report a new strategy to mitigate hearing loss associated with a common USH3 mutation CLRN1(N48K) that involves cell-based high-throughput screening of small molecules capable of stabilizing CLRN1(N48K), followed by a secondary screening to eliminate general proteasome inhibitors, and finally an iterative process to optimize structure-activity relationships...
June 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27075503/cover-image-volume-170a-number-5-may-2016
#12
Madeleine Tooley, Danielle Lynch, Francois Bernier, Jillian Parboosingh, Elizabeth Bhoj, Elaine Zackai, Alistair Calder, Nobue Itasaki, Emma Wakeling, Richard Scott, Melissa Lees, Jill Clayton-Smith, Moira Blyth, Jenny Morton, Debbie Shears, Usha Kini, Tessa Homfray, Angus Clarke, Angela Barnicoat, Colin Wallis, Rebecca Hewitson, Amaka Offiah, Michael Saunders, Simon Langton-Hewer, Tom Hilliard, Peter Davis, Sarah Smithson
The cover image, by Sarah Smithson et al., is based on the Research Article Cerebro-costo-mandibular syndrome: Clinical, radiological, and genetic findings, DOI: 10.1002/ajmg.a.37587.
May 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/26971886/cerebro-costo-mandibular-syndrome-clinical-radiological-and-genetic-findings
#13
Madeleine Tooley, Danielle Lynch, Francois Bernier, Jillian Parboosingh, Elizabeth Bhoj, Elaine Zackai, Alistair Calder, Nobue Itasaki, Emma Wakeling, Richard Scott, Melissa Lees, Jill Clayton-Smith, Moira Blyth, Jenny Morton, Debbie Shears, Usha Kini, Tessa Homfray, Angus Clarke, Angela Barnicoat, Colin Wallis, Rebecca Hewitson, Amaka Offiah, Michael Saunders, Simon Langton-Hewer, Tom Hilliard, Peter Davis, Sarah Smithson
Cerebro-Costo-Mandibular syndrome (CCMS) is a rare autosomal dominant condition comprising branchial arch-derivative malformations with striking rib-gaps. Affected patients often have respiratory difficulties, associated with upper airway obstruction, reduced thoracic capacity, and scoliosis. We describe a series of 12 sporadic and 4 familial patients including 13 infants/children and 3 adults. Severe micrognathia and reduced numbers of ribs with gaps are consistent findings. Cleft palate, feeding difficulties, respiratory distress, tracheostomy requirement, and scoliosis are common...
May 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/26929151/cell-wall-targeted-in-planta-iron-accumulation-enhances-biomass-conversion-and-seed-iron-concentration-in-arabidopsis-and-rice
#14
Haibing Yang, Hui Wei, Guojie Ma, Mauricio S Antunes, Stefan Vogt, Joseph Cox, Xiao Zhang, Xiping Liu, Lintao Bu, S Charlotte Gleber, Nicholas C Carpita, Lee Makowski, Michael E Himmel, Melvin P Tucker, Maureen C McCann, Angus S Murphy, Wendy A Peer
Conversion of nongrain biomass into liquid fuel is a sustainable approach to energy demands as global population increases. Previously, we showed that iron can act as a catalyst to enhance the degradation of lignocellulosic biomass for biofuel production. However, direct addition of iron catalysts to biomass pretreatment is diffusion-limited, would increase the cost and complexity of biorefinery unit operations and may have deleterious environmental impacts. Here, we show a new strategy for in planta accumulation of iron throughout the volume of the cell wall where iron acts as a catalyst in the deconstruction of lignocellulosic biomass...
October 2016: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/26791145/cost-of-surviving-sepsis-a-novel-model-of-recovery-from-sepsis-in-drosophila-melanogaster
#15
Ata Murat Kaynar, Veli Bakalov, Silvia Martinez Laverde, Amélie I F Cambriel, Byoung-Hoon Lee, Atif Towheed, Alyssa D Gregory, Steven A R Webb, Michael J Palladino, Fernando A Bozza, Steven D Shapiro, Derek C Angus
BACKGROUND: Multiple organ failure, wasting, increased morbidity, and mortality following acute illness complicates the health span of patients surviving sepsis. Persistent inflammation has been implicated, and it is proposed that insulin signaling contributes to persistent inflammatory signaling during the recovery phase after sepsis. However, mechanisms are unknown and suitable pre-clinical models are lacking. We therefore developed a novel Drosophila melanogaster model of sepsis to recapitulate the clinical course of sepsis, explored inflammation over time, and its relation to impaired mobility, metabolic disturbance, and changes in lifespan...
December 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/26619146/elongated-silicon-carbon-bonds-at-graphene-edges
#16
Qu Chen, Alex W Robertson, Kuang He, Chuncheng Gong, Euijoon Yoon, Angus I Kirkland, Gun-Do Lee, Jamie H Warner
We study the bond lengths of silicon (Si) atoms attached to both armchair and zigzag edges using aberration corrected transmission electron microscopy with monochromation of the electron beam. An in situ heating holder is used to perform imaging of samples at 800 °C in order to reduce chemical etching effects that cause rapid structure changes of graphene edges at room temperature under the electron beam. We provide detailed bond length measurements for Si atoms both attached to edges and also as near edge substitutional dopants...
January 26, 2016: ACS Nano
https://www.readbyqxmd.com/read/26524121/atomic-structure-of-graphene-subnanometer-pores
#17
Alex W Robertson, Gun-Do Lee, Kuang He, Chuncheng Gong, Qu Chen, Euijoon Yoon, Angus I Kirkland, Jamie H Warner
The atomic structure of subnanometer pores in graphene, of interest due to graphene's potential as a desalination and gas filtration membrane, is demonstrated by atomic resolution aberration corrected transmission electron microscopy. High temperatures of 500 °C and over are used to prevent self-healing of the pores, permitting the successful imaging of open pore geometries consisting of between -4 to -13 atoms, all exhibiting subnanometer diameters. Picometer resolution bond length measurements are used to confirm reconstruction of five-membered ring projections that often decorate the pore perimeter, knowledge which is used to explore the viability of completely self-passivated subnanometer pore structures; bonding configurations where the pore would not require external passivation by, for example, hydrogen to be chemically inert...
December 22, 2015: ACS Nano
https://www.readbyqxmd.com/read/26461042/thermally-induced-dynamics-of-dislocations-in-graphene-at-atomic-resolution
#18
Chuncheng Gong, Alex W Robertson, Kuang He, Gun-Do Lee, Euijoon Yoon, Christopher S Allen, Angus I Kirkland, Jamie H Warner
Thermally induced dislocation movements are important in understanding the effects of high temperature annealing on modifying the crystal structure. We use an in situ heating holder in an aberration corrected transmission electron microscopy to study the movement of dislocations in suspended monolayer graphene up to 800 °C. Control of temperature enables the differentiation of electron beam induced effects and thermally driven processes. At room temperature, the dynamics of dislocation behavior is driven by the electron beam irradiation at 80 kV; however at higher temperatures, increased movement of the dislocation is observed and provides evidence for the influence of thermal energy to the system...
October 27, 2015: ACS Nano
https://www.readbyqxmd.com/read/26398283/a-systematic-review-of-human-norovirus-survival-reveals-a-greater-persistence-of-human-norovirus-rt-qpcr-signals-compared-to-those-of-cultivable-surrogate-viruses
#19
REVIEW
Angus Knight, John Haines, Ambroos Stals, Dan Li, Mieke Uyttendaele, Alastair Knight, Lee-Ann Jaykus
Human noroviruses (hNoV) are the single largest cause of acute gastroenteritis in the western world. The efficacy of hNoV control measures remains largely unknown, partly owing to the inability to grow the virus in vitro and partly to the large number of surrogate studies of unknown relevance. A systematic review of the persistence and survival of hNoV in foods and the environment was undertaken based upon PRISMA (preferred reporting items for systematic reviews and meta analyses) guidelines to answer the questions: (1) "What are the natural hNoV persistence characteristics in food and the environment?" and (2) "How can these properties be altered by applying physical and/or chemical treatments to foods or food contact surfaces?" Over 10,000 citations were screened using defined inclusion and exclusion criteria...
January 4, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/26341422/differences-between-angus-and-holstein-cattle-in-the-lupinus-leucophyllus-induced-inhibition-of-fetal-activity
#20
Benedict T Green, Kip E Panter, Stephen T Lee, Kevin D Welch, James A Pfister, Dale R Gardner, Bryan L Stegelmeier, T Zane Davis
Calves with congenital defects born to cows that have grazed teratogenic Lupinus spp. during pregnancy can suffer from what is termed crooked calf syndrome. Crooked calf syndrome defects include cleft palate, spinal column defects and limb malformations formed by alkaloid-induced inhibition of fetal movement. In this study, we tested the hypothesis that there are differences in fetal activity of fetuses carried by Holstein verses Angus heifers orally dosed with 1.1 g/kg dried ground Lupinus leucophyllus. Fetal activity was monitored via transrectal ultrasonography and maternal serum was analyzed for specific lupine alkaloids...
November 2015: Toxicon: Official Journal of the International Society on Toxinology
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