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Bilateral optic neuropathy

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https://www.readbyqxmd.com/read/29627627/postoperative-posterior-ischemic-optic-neuropathy-a-left-far-lateral-craniectomy-for-resection-of-craniocervical-meningioma
#1
Ilyas M Eli, Robert B Kim, Craig Kilburg, Travis J Pecha, William T Couldwell, Sarah T Menacho
BACKGROUND: Postoperative posterior ischemic optic neuropathy (PION) is a rare cause of postoperative vision loss, most often seen when surgical patients are placed in the prone position for a prolonged period of time. The authors report a case of bilateral PION after a far-lateral craniectomy in the lateral position. CASE DESCRIPTION: A 36-year-old man with a history of right extremity numbness, weakness, and muscle atrophy was discovered to have a craniocervical meningioma...
April 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29625838/suppression-of-melatonin-secretion-in-totally-visually-blind-people-by-ocular-exposure-to-white-light-clinical-characteristics
#2
Joseph T Hull, Charles A Czeisler, Steven W Lockley
PURPOSE: Although most totally visually blind individuals exhibit nonentrained circadian rhythms due to an inability of light to entrain the circadian pacemaker, a small proportion retain photic circadian entrainment, melatonin suppression, and other nonimage-forming responses to light. It is thought that these responses to light persist because of the survival of melanospin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), which project primarily to the circadian pacemaker and are functionally distinct from the rod and cone photoreceptors that mediate vision...
April 3, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29600190/-toxocara-optic-neuropathy-clinical-features-and-ocular-findings
#3
Kwang-Dong Choi, Jae-Hwan Choi, Seo-Young Choi, Jae Ho Jung
We evaluated thirteen eyes of twelve patients diagnosed clinically and serologically with Toxocara optic neuropathy. Eleven patients had unilateral involvement and one patient had bilateral optic neuropathy. Eight patients (66.7%) had a possible infection source to Toxocara. Six patients (50%) had painless acute optic neuropathy. Ten eyes had asymmetric, sectorial optic disc edema with peripapillary infiltration and three eyes had diffuse optic disc edema. Eosinophilia was noted in five patients (41.7%) and optic nerve enhancement was observed in eight of eleven eyes (72...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29571874/identification-and-treatment-of-the-visual-processing-asymmetry-in-ms-patients-with-optic-neuritis-the-pulfrich-phenomenon
#4
Millad J Sobhanian, Rohit Agarwal, Ethan Meltzer, Eric Kildebeck, Benjamin S Frohman, Ashley N Frohman, Steven L Galetta, Shiv Saidha, Owen White, Pablo Villoslada, Friedemann Paul, Axel Petzold, Robert L Rennaker, Elena H Martinez-Lapiscina, Laura J Balcer, Randy Kardon, Elliot M Frohman, Teresa C Frohman
BACKGROUND: The Pulfrich phenomenon (PF) is the illusory perception that an object moving linearly along a 2-D plane appears to instead follow an elliptical 3-D trajectory, a consequence of inter-eye asymmetry in the timing of visual object identification in the visual cortex; with optic neuritis as a common etiology. OBJECTIVE: We have designed an objective method to identify the presence and magnitude of the PF, in conjunction with a cooresponding strategy by which to abolish the effect; with monocular application of neutral density filters to the less affected fellow eye, in patients with MS and a history of optic neuropathy (e...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29562793/wolff-parkinson-white-syndrome-and-noncompaction-in-leber-s-hereditary-optic-neuropathy-due-to-the-variant-m-3460g-a
#5
Josef Finsterer, Claudia Stollberger, Edmund Gatterer
This report describes a 66-year-old Caucasian male who acutely developed severe, bilateral impairment of visual acuity at 24 years of age. Leber's hereditary optic neuropathy (LHON) was suspected but the diagnosis was not genetically confirmed until the age of 49 years when the primary LHON mutation m.3460G>A was detected. Since onset, visual acuity had slightly improved. The family history was positive for LHON (brother, two sisters of mother, female cousin) and genetically confirmed in his brother and one aunt...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29557700/tendon-elongation-with-bovine-pericardium-in-patients-with-severe-esotropia-after-decompression-in-graves-orbitopathy-efficacy-and-long-term-stability
#6
Michael Oeverhaus, Margarethe Fischer, Herbert Hirche, Anke Schlüter, Joachim Esser, Anja K Eckstein
BACKGROUND/AIMS: We performed a retrospective analysis to examine clinical results, establish a dose-effect coefficient and analyze the long-term efficacy of tendon elongation with bovine pericardium (Tutopatch®) for surgical correction of severe esotropia, occurring after three-wall orbital decompression for dysthyroid optic neuropathy in patients with Graves' orbitopathy (GO). METHODS: Tendon elongation of the medial rectus muscle (MR) was performed in our institution using an interponate of bovine pericardium in 60 patients (27 underwent unilateral and 33 bilateral surgery)...
March 20, 2018: Strabismus
https://www.readbyqxmd.com/read/29554000/evaluation-of-vision-related-quality-of-life-in-chinese-patients-with-leber-hereditary-optic-neuropathy-and-the-g11778a-mutation
#7
Shilei Cui, Hanqiu Jiang, Jingting Peng, Jiawei Wang, Xiaojun Zhang
OBJECTIVE: To assess quality of life (QoL) measures in Chinese Leber hereditary optic neuropathy (LHON) patients with the G11778A mutation. METHODS: Chinese LHON patients with the G11778A mutation were prospectively evaluated using the Visual Function Index (VF-14) at 6 months, 1 year, and 3 years after the involvement of the second eye. Patients who completed the VF-14 at all 3 follow-up time designations were included in the analysis. RESULTS: Fifty-five patients met the inclusion criteria...
March 16, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29517388/changes-in-peripapillary-blood-vessel-density-in-graves-orbitopathy-after-orbital-decompression-surgery-as-measured-by-optical-coherence-tomography-angiography
#8
Kyle T Lewis, John R Bullock, Ryan T Drumright, Matthew J Olsen, Alan D Penman
The purpose is to evaluate the utility of optical coherence tomography (OCT) angiography in the evaluation of Graves' orbitopathy (GO) and response to orbital decompression in patients with and without dysthyroid optic neuropathy (DON). This was a single-center, prospective case series in a cohort of 12 patients (24 orbits) with GO and ±DON, (6 orbits) who underwent bilateral orbital decompression. All patients underwent pre- and postoperative OCT angiography of the peripapillary area. Vessel density indices were calculated in a 4...
March 8, 2018: Orbit
https://www.readbyqxmd.com/read/29503938/simultaneous-central-retinal-artery-occlusion-and-optic-nerve-vasculitis-in-crohn-disease
#9
Razek Georges Coussa, Andre Ali-Ridha, Natalia Vila, Rayan Alshareef, John Chen
Purpose: To describe a case of Crohn disease presenting as occlusive vasculitis resulting in a central retinal artery occlusion (CRAO) in one eye and transient ischemic optic neuropathy in the fellow eye. Observations: An 18-year-old patient recently diagnosed with biopsy-proven Crohn disease presented with CRAO OD after a previous episode of transient visual loss OS. Extensive workup was negative for other autoimmune or infectious etiologies. The patient was started on intravenous methylprednisolone for 72 h followed by maintenance dose of azathioprine and oral prednisone...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29492085/clinical-relationship-between-auditory-neuropathy-and-nervous-system-diseases
#10
Jingbo Wang, Lanlan Jin, Jun Chen, Xiaobi Fang, Zhisu Liao
Objective: To explore the clinical relationship between auditory neuropathy (AN) and nervous system diseases. Methods: A total of 134 AN patients who were treated in our hospital from December 2011 to April 2016 were selected. Then 120 cases (240 ears) with complete data of pure tone audiometry and acoustic immittance test were selected as an AN1 group, which was compared with 30 patients (49 ears) with general sensorineural hearing loss (SHL) in regard to the results of pure tone audiometry and acoustic immittance test...
November 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29467802/amiodarone-associated-optic-neuropathy-a-clinical-criteria-based-diagnosis
#11
Katrin Fasler, Ghislaine L Traber, Gregor Peter Jaggi, Klara Landau
Amiodarone-associated optic neuropathy (AAON) is a controversial diagnosis with possible impact on vital cardiac therapy decisions. This retrospective case series aims for application of distinguishing features of AAON versus non-arteritic ischaemic optic neuropathy (NAION): Bilaterality, mode of onset, degree of optic nerve dysfunction, structure of uninvolved disc (unilateral cases), and systemic toxic effects. Applying these criteria to patients with disc swelling under amiodarone, the authors identified four unilateral disc swellings, one with NAION-typical features only and three with one or more NAION-atypical features...
February 2018: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29462061/visual-loss-following-spine-surgery-what-have-we-seen-within-the-scoliosis-research-society-morbidity-and-mortality-database
#12
Jamal N Shillingford, Joseph L Laratta, Nana O Sarpong, Hasani Swindell, Meghan Cerpa, Ronald A Lehman, Lawrence G Lenke, Charla Fischer
STUDY DESIGN: A retrospective review of the Scoliosis Research Society (SRS) morbidity and mortality (M&M) database. OBJECTIVE: The aim of this study was to investigate visual related complications in spinal deformity patients undergoing spine surgery. SUMMARY OF BACKGROUND DATA: The SRS compiles surgeon-reported complications into an M&M database, tracking postoperative complications including visual loss, neurological deficits, infections, and death...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29454364/cyclosporine-a-does-not-prevent-second-eye-involvement-in-leber-s-hereditary-optic-neuropathy
#13
Stéphanie Leruez, Christophe Verny, Dominique Bonneau, Vincent Procaccio, Guy Lenaers, Patrizia Amati-Bonneau, Pascal Reynier, Clarisse Scherer, Adriana Prundean, Christophe Orssaud, Xavier Zanlonghi, Marie-Bénédicte Rougier, Caroline Tilikete, Dan Miléa
BACKRGROUND: Evaluation of the efficacy of oral cyclosporine A as a prophylactic agent in preventing second-eye involvement in Leber's hereditary optic neuropathy (LHON) in a prospective, open-label, non-randomized, multicenter pilot study. Only LHON patients aged 18 years or more, with confirmed primary mitochondrial DNA mutations and strictly unilateral optic neuropathy occurring within 6 months prior to enrolment, were included in the study. All these patients, receiving treatment with oral cyclosporine (Neoral®, Novartis) at 2...
February 17, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29429414/rapidly-progressive-neovascular-glaucoma-following-coronary-artery-bypass-graft-surgery-in-a-patient-with-type-1-diabetes-mellitus-a-case-report
#14
Vasant Raman, Rosemary Lambley
BACKGROUND: Proliferative diabetic retinopathy leading to vitreous hemorrhage, tractional retinal detachment, and neovascular glaucoma is a major cause of severe sight impairment in adults of working age worldwide. Neovascular glaucoma occurs in 2.5% of patients with proliferative diabetic retinopathy, which is difficult to treat and often leads to blindness. Onset of neovascular glaucoma with rapid progression to blindness within a few weeks of a successful coronary artery bypass graft procedure is not known with this clinical entity...
February 12, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29388319/clinical-heterogeneity-of-mitochondrial-nad-kinase-deficiency-caused-by-a-nadk2-start-loss-variant
#15
Daniel J Pomerantz, Sacha Ferdinandusse, Joy Cogan, David N Cooper, Tyler Reimschisel, Amy Robertson, Anna Bican, Tracy McGregor, Jackie Gauthier, David S Millington, Jaime L W Andrae, Michael R Tschannen, Daniel C Helbling, Wendy M Demos, Simone Denis, Ronald J A Wanders, John N Newman, Rizwan Hamid, John A Phillips
Mitochondrial NAD kinase deficiency (NADK2D, OMIM #615787) is a rare autosomal recessive disorder of NADPH biosynthesis that can cause hyperlysinemia and dienoyl-CoA reductase deficiency (DECRD, OMIM #616034). NADK2 deficiency has been reported in only three unrelated patients. Two had severe, unremitting disease; one died at 4 months and the other at 5 years of age. The third was a 10 year old female with CNS anomalies, ataxia, and incoordination. In two cases mutations in NADK2 have been demonstrated. Here, we report the fourth known case, a 15 year old female with normal intelligence and a mild clinical and biochemical phenotype presumably without DECRD...
February 1, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29372350/bilateral-vision-loss-due-to-leber-s-hereditary-optic-neuropathy-after-long-term-alcohol-nicotine-and-drug-abuse
#16
Johanna Maass, Egbert Matthé
PURPOSE: Leber's hereditary optic neuropathy is relatively rare, and no clinical pathognomonic signs exist. We present a rare case of bilateral vision loss of a patient with multiple drug abuse in the history. OBSERVATION: A 31-year-old man presented with a history of progressive, decreased vision in both eyes for 6 month. On examination, his visual acuity was hand motion in both eyes. Funduscopy demonstrated a temporal pallor of the optic disc. Goldmann visual field perimetry showed a crescent visual field in the right eye and a circular decrease to less than 50 ° in the left eye...
April 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29344076/response-to-dr-pellegrini-regarding-comments-on-bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#17
M Z Kanaan, R Pandit, Margaret Dayan
No abstract text is available yet for this article.
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344075/reply-to-bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#18
Francesco Pellegrini, Daniele Cirone, Luca De Simone, Luca Cimino, Cristina Ciabattoni
No abstract text is available yet for this article.
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344073/bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#19
M Z Kanaan, A R Lorenzi, N Thampy, R Pandit, Margaret Dayan
A 75-year-old hypertensive female with stable idiopathic intermediate uveitis presented with bilateral sequential optic neuropathy with optic disc swelling. The optic neuropathy in the first affected eye (right) was thought to be due to non-arteritic anterior ischaemic optic neuropathy (NAION). Asymptomatic left optic disc swelling was found at routine review 2 months later, and a diagnosis of giant cell arteritis (GCA) was sought. Temporal artery duplex ultrasound showed the "halo sign," but a subsequent temporal artery biopsy showed light-chain (AL) amyloidosis with no signs of giant cell arteritis...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344072/bilateral-compressive-optic-neuropathy-from-renal-osteodystrophy-caused-by-branchio-oto-renal-syndrome-stabilised-after-parathyroidectomy
#20
Arun N E Sundaram, Archana Abhayambika, Sunil Kumar
Renal osteodystrophy can cause calvarial hypertrophy and narrowing of the neural canals and foramina. Compressive optic neuropathy is extremely rare in renal osteodystrophy and was reported once only. The authors report bilateral, simultaneous compressive optic neuropathy secondary to renal osteodystrophy with features of uremic leontiasis ossea in chronic renal failure caused by branchio-oto-renal syndrome. Because of the extensive calvarial hypertrophy and the surgical difficulties envisaged with optic canal decompression, conservative approach was pursued...
December 2017: Neuro-ophthalmology
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