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Bilateral optic neuropathy

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https://www.readbyqxmd.com/read/29024675/tempo-ral-was-the-heart-of-the-matter
#1
Francesco Pellegrini, Daniele Cirone, Piernicola Machin, Rod Foroozan
A 71-year-old woman was admitted with fever, headache and weight loss associated with elevated inflammatory markers. She developed acute bilateral ophthalmoplegia and asymmetrical ptosis rapidly followed by anterior ischemic optic neuropathy. Although the first temporal artery biopsy (TAB) was negative, contralateral TAB revealed features consistent with giant cell arteritis. Even while under steroid therapy, the patient died a few days later from myocardial infarction. Acute bilateral complete ophthalmoplegia is a rare presentation of a limited number of possible diseases...
October 9, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29021915/optical-coherence-tomography-findings-in-methanol-toxicity
#2
Kendra A Klein, Alexis K Warren, Caroline R Baumal, Thomas R Hedges
BACKGROUND: Methanol toxicity poses a significant public health problem in developing countries, and in Southeast Asia, where the most common source of poisoning is via adulterated liquor in local drinks. Methanol toxicity can have devastating visual consequences and retinal specialists should be aware of the features of this toxic optic neuropathy. The authors report a case of severe systemic methanol toxicity and relatively mild optic neuropathy demonstrating unique retinal changes on optical coherence tomography (OCT)...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29018766/acute-angle-closure-following-periorbital-botulinum-toxin-injection-in-a-patient-with-retinitis-pigmentosa
#3
Jen-Chia Tsai
A 50-year-old female presented with bilateral retinitis pigmentosa (RP) and acute angle closure (AAC) with fixed mid-dilated pupil and high intraocular pressure (IOP) in the left eye following left side periorbital botulinum toxin A injection for blepharospasm. Glaucomatous optic neuropathy and retinal nerve fiber layer defect were observed in the affected eye using optical coherence tomography although the IOP was maintained at <21 mmHg after the treatment. Botulinum toxin acts at the cholinergic synapse and inhibits acetylcholine release; hence, it can cause transient mydriasis and may lead to AAC in high-risk populations such as patients with RP...
April 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/28994349/the-therapeutic-potential-of-a-calorie-restricted-ketogenic-diet-for-the-management-of-leber-hereditary-optic-neuropathy
#4
Mithu Storoni, Matthieu P Robert, Gordon T Plant
Leber hereditary optic neuropathy (LHON) is a maternally inherited, bilateral, sequential optic neuropathy that usually affects young males. LHON arises from a defect in complex I of the oxidative phosphorylation chain that generates increased reactive oxygen species and causes a decline in cellular ATP production. There exists no cure at present for LHON. Asymptomatic LHON mutation carriers show signs of increased mitochondrial biogenesis that may compensate for the compromise in complex I activity. Partial recovery in LHON is associated with a wider optic disc diameter and a younger age at disease onset, which may allow for greater mitochondrial bioenergetic capacity...
October 10, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28954746/unusual-combination-of-bilateral-ischaemic-optic-neuropathy-following-cardiac-surgery
#5
Amer Harky, Damian Balmforth, Giridhara Goli, Kit Wong
Ischaemic optic neuropathy is a rare but serious complication post cardiopulmonary bypass in cardiac surgery patients. It presents with visual loss either unilaterally or bilaterally, and it can be anterior or posterior in type depending on the segment of the optic nerve involved. In non-ocular surgery patients, the most common type is called non-arteritic ischaemic optic neuropathy. We report a case of bilateral non-arteritic ischaemic optic neuropathy following coronary artery bypass grafting and mitral valve surgeries and review the published literature for the aetiology, management and prognosis of this rare complication...
September 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28936058/multifocal-choroiditis-with-retinal-vasculitis-optic-neuropathy-and-keratoconus-in-a-young-saudi-male
#6
Yousef Dhafiri, Khalid Al Rubaie, Omar Kirat, William N May, Quan D Nguyen, Igor Kozak
The purpose of this study is to describe an association of unilateral multifocal choroiditis (MFC), retinal vasculitis, optic neuropathy, and bilateral keratoconus in a young Saudi male. A 27-year-old male patient with stable bilateral keratoconus presented with a painless vision loss in his left eye. Ophthalmic examinations revealed multiple foci of idiopathic chorioretinitis, retinal vasculitis, and mild optic disc leakage on fluorescein angiography, all of which resolved on systemic therapy with mycophenolate mofetil and prednisone after 3 months...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28902089/new-insights-in-vanishing-white-matter-disease-isolated-bilateral-optic-neuropathy-in-adult-onset-disease
#7
Sandra R Barros, Sónia C R Parreira, Ana F B Miranda, Ana M B Pereira, Nuno M P Campos
BACKGROUND: Vanishing white matter disease (VWMD) is a rare disease affecting cerebral white matter. The adult form is even rarer and manifests with motor symptoms, behavioral problems, and dementia. There is no treatment and progression is inevitable. We describe a case with atypical manifestations and an unusual course. METHODS: Description of a 42-year-old man with VWMD complaining of progressive visual loss in the right eye. RESULTS: The patient's visual acuity was 20/60, right eye, and 20/25, left eye, with pale optic nerves bilaterally...
September 7, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28836961/visual-outcome-following-bilateral-non-arteritic-anterior-ischemic-optic-neuropathy-a-systematic-review-and-meta-analysis
#8
Shay Keren, Mario Zanolli, Gad Dotan
BACKGROUND: Many patients who suffer unilateral non-arteritic anterior ischemic optic neuropathy (NAION) will eventually develop the same condition in their other eye, worrying them about losing vision in both eyes. The purpose of this meta-analysis is to determine whether it is possible to predict the visual outcome of the consecutive NAION event based on initial presentation and to compare mean visual loss of firstly versus secondly affected eyes. METHODS: A systematic review and meta-analysis of studies published between January 1st 1966 and May 31st 2016 reporting on visual acuity and/or visual field loss of both affected eyes, measured either at presentation or follow-up following bilateral NAION...
August 24, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28781891/vascular-occlusions-following-ocular-surgical-procedures-a-clinical-observation-of-vascular-complications-after-ocular-surgery
#9
Charlotte Fischer, Anne Bruggemann, Annette Hager, Josep Callizo Planas, Johann Roider, Hans Hoerauf
BACKGROUND: Ocular vascular occlusions following intraocular procedures are a rare complication. We report a case series of patients with retinal vascular occlusions or anterior ischemic optic neuropathy (AION) after anterior and posterior segment surgery and demonstrate possible risk factors. METHODS: Observational case series. RESULTS: In ten patients, vascular occlusions were observed within ten weeks after intraocular surgery: branch retinal arterial occlusion (BRAO) (n = 2), central retinal artery occlusion (CRAO) (n = 2), central retinal vein occlusion (CRVO) (n = 1), branch retinal vein occlusion (BRVO) (n = 1), anterior ischemic optic neuropathy (AION) (n = 3), and combined central artery and vein occlusion (n = 1)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28765059/bing-neel-syndrome-bilateral-cavernous-sinus-lymphoma-causing-visual-failure
#10
Chengde Pham, James D Griffiths, Anthony Kam, Martin K Hunn
We report the case of a 68-year-old male with right eye vision loss secondary to a compressive optic neuropathy from Waldenstrom macroglobulinaemia relapse in both cavernous sinuses. Central nervous system involvement is extremely uncommon in lymphoplasmacytic lymphoma. Known as Bing-Neel syndrome, this has not been previously reported to present simultaneously in bilateral cavernous sinuses. We discuss the pathophysiology, diagnostic and neuroradiological features of Bing-Neel syndrome. In this case, there was marked clinical and radiological response to chemotherapy...
July 29, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28761322/optimization-of-a-genotyping-screening-based-on-hydrolysis-probes-to-detect-the-main-mutations-related-to-leber-hereditary-optic-neuropathy-lhon
#11
Fábio Tadeu Arrojo Martins, Paulo Maurício do Amor Divino Miranda, Marcela Scabello Amaral Fernandes, Andréa Trevas Maciel-Guerra, Edi Lúcia Sartorato
PURPOSE: Leber hereditary optic neuropathy (LHON) is a mitochondrial inherited disease characterized by bilateral vision problems, such as reduced visual acuity, dyschromatopsia, and central or centrocecal scotoma. Of these cases, 95% are caused by three mutations in mitochondrial DNA (mtDNA): m.G11778A, followed by m.T14484C and m.G3460A. The remaining 5% of cases of LHON are caused by rare mutations also present in mtDNA. Although conventional molecular tools for molecular screening of LHON are becoming popular, in most cases these tools are still expensive and time-consuming and are difficult to reproduce...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28745242/leber-s-heriditary-optic-neuropathy-the-shift-from-an-opthalmologic-disease-to-a-multi-systemic-paradigm
#12
Jasna Jancic, Stevan Stojanovic, Amalija Stojanovic, Ana Marija Milanovic, Blazo Nikolic, Nikola Ivancevic, Janko Samardzic
Leber's hereditary optic neuropathy is an inherited form of optic neuropathy, genetically and based on mitochondrial insufficiency causing bilateral loss of central vision mostly at a young age. Despite being one of the most common mitochondrial diseases, the explanation for its pathophysiological background and effective clinical solutions remain elusive. Widening the scope in the search for pathological findings beyond the optic system has yielded several non-ophthalmologic findings, which might imply that Leber's hereditary optic neuropathy is in fact a multi-systemic disease...
July 24, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28729193/the-pattern-of-retinal-ganglion-cell-dysfunction-in-leber-hereditary-optic-neuropathy
#13
A Majander, A G Robson, C João, G E Holder, P F Chinnery, A T Moore, M Votruba, A Stockman, P Yu-Wai-Man
Leber inherited optic neuropathy (LHON) is characterized by subacute bilateral loss of central vision due to dysfunction and loss of retinal ganglion cells (RGCs). Comprehensive visual electrophysiological investigations (including pattern reversal visual evoked potentials, pattern electroretinography and the photopic negative response) performed on 13 patients with acute and chronic LHON indicate early impairment of RGC cell body function and severe axonal dysfunction. Temporal, spatial and chromatic psychophysical tests performed on 7 patients with acute LHON and 4 patients with chronic LHON suggest severe involvement or loss of the midget, parasol and bistratified RGCs associated with all three principal visual pathways...
September 2017: Mitochondrion
https://www.readbyqxmd.com/read/28724826/bilateral-normal-tension-glaucoma-can-this-be-nutritional
#14
Sirisha Senthil, Kiranmaye Turaga
Normal tension glaucoma (NTG) also known as low tension glaucoma, presents with optic nerve head and visual field damage in the absence of high intraocular pressure (<21 mmHg). There are several patients of NTG seen in our clinics who have repeatable visual field defects, which may or may not correlate with the disc appearance, but are labeled as glaucoma. Ruling out ischemic, nutritional, and other causes of one-time damage are important before diagnosing an NTG. We report 3 such cases that were misdiagnosed and referred as NTG...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28688625/bilateral-retrobulbar-optic-neuropathy-as-the-only-sign-of-zoledronic-acid-toxicity
#15
Félix Manco Lavado, Marta Para Prieto, María Rosalba Ramoa Osorio, María Isabel López Gálvez, Lucía Manzanas Leal
INTRODUCTION: Bisphosphonates may rarely cause ocular adverse effects and retrobulbar optic neuropathy (RON) secondary to zoledronic acid is very rare. CASE REPORT: A 67-year-old man was referred because of progressive and painless decrease vision in the left eye. He had been treated with 7 cycles of zoledronic acid infusions because of metastatic prostate cancer. On examination, VA was 20/20 in the right eye (OD) and 20/50 in the left eye (OS). The optic nerve was unremarkable OU...
October 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28668421/quantitative-assessment-of-optic-nerve-in-patients-with-leber-s-hereditary-optic-neuropathy-using-reduced-field-of-view-diffusion-tensor-imaging
#16
Ling Wang, Ke Fan, Yanqiu Zhang, Yanzi Chen, Qin Tian, Dapeng Shi
PURPOSE: To quantitatively analyze the optic nerve alterations in chronic Leber's hereditary optic neuropathy (LHON) using reduced field-of-view diffusion tensor imaging (rFOV-DTI) and evaluate the correlation of diffusion parameters with visual functional and peripapillary retinal nerve fiber layer (RNFL) thickness. METHODS: Twenty-five patients (50 affected optic nerves) with chronic LHON and 28 healthy controls (56 normal optic nerves) were enrolled. The rFOV-DTI was performed in the bilateral optic nerves for all the subjects...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28647203/gene-therapy-for-leber-hereditary-optic-neuropathy-low-and-medium-dose-visual-results
#17
John Guy, William J Feuer, Janet L Davis, Vittorio Porciatti, Phillip J Gonzalez, Rajeshwari D Koilkonda, Huijun Yuan, William W Hauswirth, Byron L Lam
PURPOSE: To determine the effects of AAV2(Y444,500,730F)-P1ND4v2 in patients with Leber hereditary optic neuropathy (LHON). DESIGN: Prospective open-label, unilateral single-dose, intravitreal injection of AAV2(Y444,500,730F)-P1ND4v2 per participant. PARTICIPANTS: Fourteen patients with visual loss and mutated G11778A mitochondrial DNA. METHODS: Intravitreal injection with the gene therapy vector AAV2(Y444,500,730F)-P1ND4v2 into 1 eye...
June 21, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28630249/bilateral-ischaemic-optic-neuropathy-and-retinopathy-along-with-cortical-infarct-in-a-case-of-takayasu-disease
#18
Nripen Gaur, Pradeep Sharma, Brijesh Takkar, Jagjeet Singh
No abstract text is available yet for this article.
June 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28590394/the-outcome-of-endoscopic-optic-nerve-decompression-for-bilateral-traumatic-optic-neuropathy
#19
Daoyu Xie, Hailing Yu, Jianbao Ju, Li Zhang
OBJECTIVE: To investigate the outcomes of endoscopic optic nerve decompression (EOND) for bilateral traumatic optic neuropathy (TON). METHODS: A retrospective analysis was conducted in 5 patients with bilateral TON, between January 2003 and December 2013. All the patients underwent preoperative ophthalmological evaluation, flash visual-evoked potentials, computed tomography scan, and systemic corticosteroid therapy. All the patients required an EOND surgery, due to poor response to medical therapy, and the remainder one was only treated with corticosteroid due to operative contraindication...
June 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28545357/an-uncommon-case-of-symptomatic-multiple-meningiomas-with-bilateral-compressive-optic-neuropathy-rapidly-induced-under-cyproterone-acetate-treatment
#20
Chafik Keilani, Samir Abada
Multiple meningiomas growth in patients under cyproterone acetate (CPA) is now well known. However, time between initial CPA intake and diagnosis remains unclear. The exposure time differs in each reported case: from 2 to 10 years. We present the case of an old man with acute visual impairment caused by an unusual bilateral optic nerve compression by three likely planum sphenoidale meningiomas rapidly induced by the admistration of CPA for prostatic adenocarinoma. This case is the first reported with a short exposure time (7 months) to CPA treatment before diagnosis of multiple meningiomas and stabilization on clinical follow-up after CPA treatment discontinuation...
May 23, 2017: Current Drug Safety
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