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https://www.readbyqxmd.com/read/28166917/two-cases-of-eyelid-tuberculosis-an-uncommon-presentation-of-ocular-tuberculosis
#1
D K Bajaj, A Srivastava, R A S Kushwaha, A Joshi, M K Pandey, P Mishra, M Asnani
Mycobacterium tuberculosis apart from being the causative agent of pulmonary tuberculosis is also notorious to cause tuberculosis at various sites in the human body and ocular tuberculosis is one of the extra pulmonary manifestations of this organism. The most common presentation of ocular tuberculosis is anterior uveitis or choroiditis caused by hematogenous infection or hypersensitivity after another organ infection. Eyelid involvement by tuberculosis is most of the times secondary to orbital involvement and often seen in the form of drainage sinus...
January 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28138184/genexpert-a-new-tool-for-the-rapid-detection-of-rifampicin-resistance-in-mycobacterium-tuberculosis
#2
Muhammad Saeed, Shagufta Iram, Shahida Hussain, Adeel Ahmed, Mamoon Akbar, Maleeha Aslam
OBJECTIVE: To evaluate the diagnostic accuracy of GeneXpert assay for the detection of rifampicin resistance in mycobacterium tuberculosis using conventional drug susceptibility testing as gold standard. METHODS: This cross-sectional study was conducted at Jinnah Hospital, Lahore, / Allama Iqbal Medical College, Lahore, Pakistan, from January 2012 to December 2014, and comprised clinically and radiologically diagnosed tuberculosis suspected cases. Pulmonary and extra-pulmonary specimens were collected from strong tuberculosis suspects...
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28129755/improving-case-detection-of-tuberculosis-among-children-in-bangladesh-lessons-learned-through-an-implementation-research
#3
Ziaul Islam, Kazi Istiaque Sanin, Tahmeed Ahmed
BACKGROUND: According to the Bangladesh National Tuberculosis Control Program (NTP), the proportion of childhood tuberculosis (TB) among all reported cases is only 3%. This is considerably lower compared to other high-burden countries. One of our previous studies identified substantial gaps at the primary care level related to capacity of service providers, supply of required logistics and community awareness about childhood TB. Therefore, we conducted an implementation study with the objectives to address those gaps...
January 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28123961/mdr-tb-in-puducherry-india-reduction-in-attrition-and-turnaround-time-in-the-diagnosis-and-treatment-pathway
#4
H D Shewade, S Govindarajan, P Thekkur, C Palanivel, M Muthaiah, A M V Kumar, V Gupta, B N Sharath, J P Tripathy, K Vivekananda, G Roy
Setting: A mixed-methods operational research (OR) study was conducted to examine the diagnosis and treatment pathway of patients with presumptive multidrug-resistant tuberculosis (MDR-TB) during 2012-2013 under the national TB programme in Puducherry, India. High pre-diagnosis and pre-treatment attrition and the reasons for these were identified. The recommendations from this OR were implemented and we planned to assess systematically whether there were any improvements. Objectives: Among patients with presumptive MDR-TB (July-December 2014), 1) to determine pre-diagnosis and pre-treatment attrition, 2) to determine factors associated with pre-diagnosis attrition, 3) to determine the turnaround time (TAT) from eligibility to testing and from diagnosis to treatment initiation, and 4) to compare these findings with those of the previous study (2012-2013)...
December 21, 2016: Public Health Action
https://www.readbyqxmd.com/read/28081227/diagnostic-accuracy-of-genexpert-mtb-rif-assay-in-comparison-to-conventional-drug-susceptibility-testing-method-for-the-diagnosis-of-multidrug-resistant-tuberculosis
#5
Pratikshya Pandey, Narayan Dutt Pant, Komal Raj Rijal, Bhawana Shrestha, Sirita Kattel, Megha Raj Banjara, Bhagwan Maharjan, Rajendra Kc
Xpert MTB/RIF assay is regarded as a great achievement of modern medicine for the rapid diagnosis of multidrug-resistant tuberculosis (MDR-TB). The main purpose of this study was to determine the performance of Xpert MTB/RIF assay compared to conventional drug susceptibility testing (DST) method for the diagnosis of MDR-TB. A comparative cross sectional study was carried out at German-Nepal Tuberculosis Project, Kathmandu, Nepal, from April 2014 to September 2014. A total of 88 culture positive clinical samples (83 pulmonary and 5 extra-pulmonary) received during the study period were analyzed for detection of multidrug-resistant tuberculosis by both GeneXpert MTB/RIF assay and conventional DST method...
2017: PloS One
https://www.readbyqxmd.com/read/28060846/prediction-of-under-detection-of-paediatric-tuberculosis-in-the-democratic-republic-of-congo-experience-of-six-years-in-the-south-kivu-province
#6
Emmanuel André, Yvette Lufungulo Bahati, Eric Mulume Musafiri, Olivier Bahati Rusumba, Dimitri Van der Linden, Francis Zech
INTRODUCTION: In the field of tuberculosis (TB), and particularly in regard to paediatric TB (PedTB), clinical skills of health professionals play an important role in determining quality of care. In an era where novel diagnostic technologies and efficient treatment regimens are being made available for the poorest, we must not divert our attention from the importance of clinical skills, as this deliverable remains the cornerstone of individualized patient care and ultimately the best assurance for optimal use of resources...
2017: PloS One
https://www.readbyqxmd.com/read/28058538/factors-influencing-the-choice-of-first-and-second-line-biologic-therapy-for-the-treatment-of-rheumatoid-arthritis-real-life-data-from-the-italian-lorhen-registry
#7
Sara Monti, Catherine Klersy, Roberto Gorla, Piercarlo Sarzi-Puttini, Fabiola Atzeni, Raffaele Pellerito, Enrico Fusaro, Giuseppe Paolazzi, Pier Andrea Rocchetta, Ennio Giulio Favalli, Antonio Marchesoni, Roberto Caporali
According to international recommendations, the selection of the biologic disease modifying anti-rheumatic drug (bDMARD) for rheumatoid arthritis (RA) is mainly left to the clinician's preference. We analyzed the real-life factors influencing the first-line choice or the switching strategy, focusing on the prescription of abatacept (ABA) or tocilizumab (TCZ) compared to TNFα inhibitors (TNFi). Patients enrolled in the Lombardy Rheumatology Network (LORHEN) Registry after January 1, 2010, when all considered bDMARD agents were available, were included...
January 5, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28057041/rifampicin-resistance-pattern-of-mycobacterium-tuberculosis-and-associated-factors-among-presumptive-tuberculosis-patients-referred-to-debre-markos-referral-hospital-ethiopia-a-cross-sectional-study
#8
Wondemagegn Mulu, Bayeh Abera, Mulat Yimer, Tadesse Hailu, Haimanot Ayele, Dereje Abate
BACKGROUND: Prevailing data on rifampicin-resistant M. tuberculosis is essential for early management of MDR-TB. Therefore, this study was conducted to determine the prevalence of rifampicin-resistant Mycobacterium tuberculosis and associated factors among presumptive TB cases in Debre Markos Referral Hospital, Ethiopia. METHODS: A cross-sectional study was conducted from September 2014 to March 2015. Detection of M. tuberculosis and resistance to rifampicin was performed using Gene Xpert MTB/RIF assay...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28050442/pancreatic-tuberculosis-a-puzzle-for-physicians-a-rare-case-and-review-of-literature
#9
Prashanth Ashok Kumar, Gursharan Singh, John Biku Joseph, S Swaminathan, L Venkatakrishnan
Pancreatic Tuberculosis is an uncommon form of extra pulmonary tuberculosis that resembles malignancy of pancreas and serve as a diagnostic challenge for physicians. Conservative management with Anti Tuberculosis Therapy (ATT) will suffice for pancreatic tuberculosis whereas a malignancy may require major surgeries which may lead to significant morbidity. Here, we discuss the case of a female patient who presented with abdominal pain and vomiting and is a known case of chronic calcific pancreatitis. Radiological findings were that of malignancy of the pancreas...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28043613/emotional-distress-patients-with-several-types-of-tuberculosis-a-pilot-study-with-patients-from-the-sanatorium-hospital-of-huambo
#10
Benvinda Xavier Paulo, Bruno Peixoto
BACKGROUND: There is growing evidence that emotional distress expressed in terms of anxiety and depression it is very high among tuberculosis (TB) patients. OBJECTIVES: This study aims to determine levels of anxiety, depression and emotional distress in patients with several types of TB and to determine the association between social-demographic and economical factors, clinical variables and anxiety, depression and emotional distress. METHODS: A cross-sectional study was performed in a sample of 81 TB patients...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043552/role-of-socio-demographical-factors-on-tuberculosis-outcome-in-yemen
#11
Ammar Ali Saleh Jaber, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Nafees Ahmad
OBJECTIVES: Tuberculosis (TB) is an infection disease caused by an organism called Mycobacterium tuberculosis (tubercle bacilli). Tuberculosis remains the most common infection worldwide (Organization & World Health Organization, 2013). Yemen situated in WHO Eastern Mediterranean Region and ranked as intermediate TB-burdened countries. TB considers as one of the main health problems; it ranks as the fourth in the priority of the public health issue (NTCP, 2010). The study was conducted to evaluate the Socio-Demographical variables on tuberculosis treatment outcome...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043502/genotypic-analysis-of-multidrug-resistant-tuberculosis-isolates-from-extra-pulmonary-tuberculosis-cases-in-tertiary-care-centers-in-northern-india
#12
Anand K Maurya, Vijaya L Nag, Surya Kant, Ramawadh S Kushwaha, Tapan N Dhole
OBJECTIVE/BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem. The diagnosis of MDR-TB is of paramount importance in establishing appropriate clinical management and infection control measures. Rapid detection of MDR-TB allows the establishment of an effective treatment regimen, minimizes the risk of further resistance, and limits the spread of drug-resistant strains. The aim of this study is to determine the genotypic characterization of MDR-TB isolates from extra pulmonary tuberculosis (EPTB) cases in tertiary care centers in Northern India...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043497/ten-years-experience-of-directly-observed-treatment-short-course-dots-in-gambella-regional-state-ethiopia-an-evaluation-of-tuberculosis-control-program
#13
Solomon Sisay, Belete Mengistu, Woldargay Erku, Desalegne Woldeyohannes
BACKGROUND: World Health Organization (WHO) declared tuberculosis (TB) as a global public health emergency and recommended DOTS as a standard strategy for controlling the disease. TB is one of the major causes of infectious diseases in the world, and 25% of all avoidable deaths in developing countries. About a third of the world's population is estimated to be infected with tubercle bacilli, and hence at risk of developing active disease. The objective of the study was, therefore, to evaluate the impact of DOTS strategy on smear-positive pulmonary tuberculosis case finding and their treatment outcomes in Gambella Regional State, Ethiopia...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043495/development-of-rapid-immuno-diagnostic-test-for-the-early-detection-of-tuberculosis
#14
Anil Kumar Gupta, Saumya Srivastava, Amit Singh, Sarman Singh
AIMS AND OBJECTIVE: To develop novel immunodiagnostic test for tuberculosis. METHODS: The selected novel proteins named as Rv2145c (SS1), Rv1437 (SS2), Rv1827 (SS3), and Rv2970c (SS4) were cloned, expressed and purified under specific conditions. Additionally, monoclonal antibodies (mAbs) were developed using these recombinant antigens via hybridoma technology. Hybridoma clones were screened and positive clones were selected for further experiment. The mAbs were purified from cell culture supernatant using protein A/G column chromatography...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043486/tuberculosis-in-children
#15
Ali Akbar Velayati
Tuberculosis (TB) is the main cause of infection-related death in the world. Children make up ∼5-15% of all TB cases. Severe forms of disease such as meningitis and disseminated form are more common in children. Due to current estimates of World Health Organization (WHO) in 2015, one million children suffer from TB around the world; of these, it is estimated that more than 136,000 die a year. One study estimated 67million children with latent TB which develops to active form with the rate of ∼850,000 each year...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28024452/positive-predictive-value-of-elispot-in-bal-and-pleural-fluid-from-patients-with-suspected-pulmonary-tuberculosis
#16
Regina W Hofland, Steven F T Thijsen, Anne S R van Lindert, Wiel C M de Lange, Tamara van Gorkom, Ingeborg van der Tweel, Jan-Willem J Lammers, Aik W J Bossink
BACKGROUND: The aim of this study was to evaluate the positive predictive value (PPV) of ELISpot in bronchoalveolar lavage (BAL) and pleural fluid for the diagnosis of active tuberculosis (TB) in real-life clinical practice, together with the added value of a cut-off >1.0 for the ratio between the extra-sanguineous and systemic interferon-gamma responses in positive samples. METHODS: A retrospective, single-centre study was performed. Patients with positive ELISpot in BAL and pleural fluid were included...
December 26, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/28011966/performance-of-real-time-pcr-xpert-%C3%A2-mtb-rif-in-diagnosing-extrapulmonary-tuberculosis
#17
Ester Mazzola, Marco Arosio, Alice Nava, Diana Fanti, Giovanni Gesu, Claudio Farina
The real time PCR Xpert ® MTB/RIF is fundamental for rapid diagnosis in paucibacillary respiratory samples and for the detection of multidrug-resistant TB cases. This paper aimed to determine its performance on different extrapulmonary samples. We determined sensitivity, specificity, positive and negative predictive value on respiratory and non-respiratory samples collected from January 2010 to June 2014. The protocol for the Xpert ® MTB/RIF PCR suggested by Cepheid was strictly followed for all specimens...
1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28011853/whole-genome-sequencing-identifies-nosocomial-transmission-of-extra-pulmonary-m-tuberculosis
#18
T M Walker, D W Crook, T E A Peto, C P Conlon
No abstract text is available yet for this article.
December 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28006720/isolated-primary-tuberculosis-of-spleen-a-rare-entity-in-the-immuno-competent-patient
#19
Suneed Kumar, Ajay G Pai, Pravin N Tungenwar, Ajay H Bhandarwar
INTRODUCTION: Tuberculosis is a global public health concern, with 9.6 million affected individuals worldwide. Current screening and diagnostic regimes focus primarily on smear positivity, and hence, the rising numbers of Sputum negative and Extra-Pulmonary Tuberculosis has become a significant set-back to adequate diagnosis, disease notification and treatment, due to the large number of false negatives. PRESENTATION OF CASE: We hereby describe an intriguing presentation of tuberculosis - A 23 yr old lady with no comorbid illness, came to us with ten month history of on and off pyrexia, weakness and left hypochondriac pain...
November 25, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27958360/diagnostic-test-accuracy-of-loop-mediated-isothermal-amplification-assay-for-mycobacterium-tuberculosis-systematic-review-and-meta-analysis
#20
Kenjiro Nagai, Nobuyuki Horita, Masaki Yamamoto, Toshinori Tsukahara, Hideyuki Nagakura, Ken Tashiro, Yuji Shibata, Hiroki Watanabe, Kentaro Nakashima, Ryota Ushio, Misako Ikeda, Atsuya Narita, Akinori Kanai, Takashi Sato, Takeshi Kaneko
Diagnostic test accuracy of the loop-mediated isothermal amplification (LAMP) assay for culture proven tuberculosis is unclear. We searched electronic databases for both cohort and case-control studies that provided data to calculate sensitivity and specificity. The index test was any LAMP assay including both commercialized kits and in-house assays. Culture-proven M. tuberculosis was considered a positive reference test. We included 26 studies on 9330 sputum samples and one study on 315 extra-pulmonary specimens...
December 13, 2016: Scientific Reports
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