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https://www.readbyqxmd.com/read/28337993/evaluation-of-5-novel-protein-biomarkers-for-the-rapid-diagnosis-of-pulmonary-and-extra-pulmonary-tuberculosis-preliminary-results
#1
Amit Singh, Anil Kumar Gupta, Krishnamoorthy Gopinath, Pawan Sharma, Sarman Singh
Improved methods are required for the early and accurate diagnosis of tuberculosis, especially in the patients with smear-negative disease. Several biomarkers have been tried but most have shown poor sensitivity or specificity. In present study we aimed to evaluate the diagnostic utility of five novel antigens identified earlier by us. This is an initial study conducted on 250 subjects. The five recombinant antigens, named as rSS1 (Rv2145c), rSS2 (Rv0164), rSS3 (Rv1437), rSS4 (Rv1827) and rSS5 (Rv2970c), were expressed in pQE-30 expression vector, purified and their sero-diagnostic efficacy was evaluated in an unblinded manner using dot-blot and ELISA methods...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317400/nanodiagnostics-for-tuberculosis-detection
#2
Hesham El-Samadony, Asma Althani, Mohamed Awad Tageldin, Hassan M E Azzazy
Introduction Tuberculosis (TB) is a leading killer worldwide. End TB strategy aims at ending the TB epidemic by 2030. Early, accurate, and affordable diagnosis represents a cornerstone to achieve this goal. Innovative strategies for TB diagnostics have been introduced, however the ideal assay is yet unavailable and conventional methods remain necessary for diagnosis. Unique properties of nanoparticles (NPs) have allowed their utilization in TB detection via targeting disease biomarkers. Area Covered Until now, around thirty-five TB NP-based assays have been partially or fully characterized...
March 20, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28284274/initial-screening-of-extra-pulmonary-tuberculosis-using-the-xpert-mtb-rif-assay-improves-case-detection-rates
#3
Amita Jain, Pravin Kumar Singh, Urmila Singh, Vijay Kumar
No abstract text is available yet for this article.
April 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28284254/tuberculosis-hospitalization-expenditures-per-patient-from-private-health-insurance-claims-data-2010-2014
#4
K Owusu-Edusei, S M Marks, R Miramontes, E L Stockbridge, C A Winston
OBJECTIVE: To determine hospitalization expenditures for tuberculosis (TB) disease among privately insured patients in the United States. METHODS: We extracted TB hospital admissions data from the 2010-2014 MarketScan® commercial database using International Classification of Diseases version 9 codes for TB (011.0-018.96) as the principal diagnosis. We estimated adjusted average expenditures (in 2014 USD) using regression analyses controlling for patient and claim characteristics...
April 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28276626/exploration-on-the-risk-factors-of-pulmonary-tuberculosis-incidence-in-wenchuan-earthquake-stricken-area
#5
Xiaoyan Yang, Hailong Zhou, Xiaoping Pan
AIM: To explore the risk factors of pulmonary tuberculosis incidence in Wenchuan earthquake-stricken area during a nine-year period of time. METHODS: The incidence and socio-economic indicators in the 181 counties of Sichuan province from 2004 to 2012 were collected, multilevel extra-Poisson model was performed for variable screening, Bayesian spatio-temporal models were fitted. RESULTS: The morbidity showed a downward time trend from 2004 to 2012...
February 3, 2017: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/28275073/rapid-detection-of-cell-free-mycobacterium-tuberculosis-dna-in-tuberculous-pleural-effusion
#6
Nanying Che, Xinting Yang, Zichen Liu, Kun Li, Xiaoyou Chen
Tuberculous pleurisy is one of the most common extra-pulmonary tuberculosis, but its diagnosis remains to be difficult. In this study, we for the first time report detection of cell-free Mycobacterium tuberculosis DNA in pleural effusion and evaluation of this newly developed molecular assay. A total of 78 patients with pleural effusion, 60 patients with tuberculous pleurisy and 18 patients with alternative diseases, were included in this study. Mycobacterial culture, Xpert MTB/RIF assay, adenosine deaminase assay, T-SPOT...
March 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28260763/a-retrospective-histopathological-study-on-extra-pulmonary-tuberculosis-in-mymensingh
#7
A Begum, M A Baten, Z Begum, M M Alam, M M Ahsan, N P Ansari, S Zahan, M K Khan, F Nesa, M M Huq
Tuberculosis is a very common disease in our country. This retrospective histopathological study was designed to assess the distribution of extra-pulmonary tuberculosis (EPTB) in various organs through examination of biopsy specimens. A total of 216 specimens were diagnosed as tubercular lesion by histopathological evaluation in the Department of pathology, Community Based Medical College and a private laboratory during the period from January 2014 to December 2014. Mean age of the case was 32 years. Majority of the cases were female (126 out of 216)...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28250686/prevalence-of-tuberculosis-among-children-in-north-sudan-are-we-only-seeing-the-tip-of-the-iceberg
#8
Wadie M Elmadhooun, Elmuntasir Taha Salah, Sufian K Noor, Sarra O Bushara, Ekhlas O Ahmed, Hamdan Mustafa, Amel A Sulaiman, Mohamed H Ahmed
INTRODUCTION: Tuberculosis (TB) is a significant cause of morbidity and mortality among children. The vague symptoms, the uncertain diagnostic tests and lack of adequate awareness among families all contributed in masking the actual prevalence of the disease. The objective of this study was to describe the epidemiology of childhood TB in River Nile State (RNS), North Sudan. METHODS: All registered cases of TB aged 15 years and below, at the 13 management units in RNS during 3 years, 2011-2013 were included...
January 2017: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/28225336/paediatric-tuberculosis-in-queensland-australia-overrepresentation-of-cross-border-and-indigenous-children
#9
E J Donnan, C Coulter, G Simpson, J Clark, C Nourse
SETTING: Queensland, Australia. BACKGROUND: Understanding paediatric tuberculosis (TB) is important, as children with TB typically reflect recent community transmission. Children pose unique diagnostic challenges and are at risk of developing severe disseminated infection. OBJECTIVE: To describe the epidemiology, presentation and outcomes of children with TB disease in Queensland. DESIGN: This is a retrospective case series of children diagnosed with TB aged 0-16 years notified in 2005-2014...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28166917/two-cases-of-eyelid-tuberculosis-an-uncommon-presentation-of-ocular-tuberculosis
#10
D K Bajaj, A Srivastava, R A S Kushwaha, A Joshi, M K Pandey, P Mishra, M Asnani
Mycobacterium tuberculosis apart from being the causative agent of pulmonary tuberculosis is also notorious to cause tuberculosis at various sites in the human body and ocular tuberculosis is one of the extra pulmonary manifestations of this organism. The most common presentation of ocular tuberculosis is anterior uveitis or choroiditis caused by hematogenous infection or hypersensitivity after another organ infection. Eyelid involvement by tuberculosis is most of the times secondary to orbital involvement and often seen in the form of drainage sinus...
January 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28138184/genexpert-a-new-tool-for-the-rapid-detection-of-rifampicin-resistance-in-mycobacterium-tuberculosis
#11
Muhammad Saeed, Shagufta Iram, Shahida Hussain, Adeel Ahmed, Mamoon Akbar, Maleeha Aslam
OBJECTIVE: To evaluate the diagnostic accuracy of GeneXpert assay for the detection of rifampicin resistance in mycobacterium tuberculosis using conventional drug susceptibility testing as gold standard. METHODS: This cross-sectional study was conducted at Jinnah Hospital, Lahore, / Allama Iqbal Medical College, Lahore, Pakistan, from January 2012 to December 2014, and comprised clinically and radiologically diagnosed tuberculosis suspected cases. Pulmonary and extra-pulmonary specimens were collected from strong tuberculosis suspects...
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28129755/improving-case-detection-of-tuberculosis-among-children-in-bangladesh-lessons-learned-through-an-implementation-research
#12
Ziaul Islam, Kazi Istiaque Sanin, Tahmeed Ahmed
BACKGROUND: According to the Bangladesh National Tuberculosis Control Program (NTP), the proportion of childhood tuberculosis (TB) among all reported cases is only 3%. This is considerably lower compared to other high-burden countries. One of our previous studies identified substantial gaps at the primary care level related to capacity of service providers, supply of required logistics and community awareness about childhood TB. Therefore, we conducted an implementation study with the objectives to address those gaps...
January 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28123961/mdr-tb-in-puducherry-india-reduction-in-attrition-and-turnaround-time-in-the-diagnosis-and-treatment-pathway
#13
H D Shewade, S Govindarajan, P Thekkur, C Palanivel, M Muthaiah, A M V Kumar, V Gupta, B N Sharath, J P Tripathy, K Vivekananda, G Roy
Setting: A mixed-methods operational research (OR) study was conducted to examine the diagnosis and treatment pathway of patients with presumptive multidrug-resistant tuberculosis (MDR-TB) during 2012-2013 under the national TB programme in Puducherry, India. High pre-diagnosis and pre-treatment attrition and the reasons for these were identified. The recommendations from this OR were implemented and we planned to assess systematically whether there were any improvements. Objectives: Among patients with presumptive MDR-TB (July-December 2014), 1) to determine pre-diagnosis and pre-treatment attrition, 2) to determine factors associated with pre-diagnosis attrition, 3) to determine the turnaround time (TAT) from eligibility to testing and from diagnosis to treatment initiation, and 4) to compare these findings with those of the previous study (2012-2013)...
December 21, 2016: Public Health Action
https://www.readbyqxmd.com/read/28081227/diagnostic-accuracy-of-genexpert-mtb-rif-assay-in-comparison-to-conventional-drug-susceptibility-testing-method-for-the-diagnosis-of-multidrug-resistant-tuberculosis
#14
Pratikshya Pandey, Narayan Dutt Pant, Komal Raj Rijal, Bhawana Shrestha, Sirita Kattel, Megha Raj Banjara, Bhagwan Maharjan, Rajendra Kc
Xpert MTB/RIF assay is regarded as a great achievement of modern medicine for the rapid diagnosis of multidrug-resistant tuberculosis (MDR-TB). The main purpose of this study was to determine the performance of Xpert MTB/RIF assay compared to conventional drug susceptibility testing (DST) method for the diagnosis of MDR-TB. A comparative cross sectional study was carried out at German-Nepal Tuberculosis Project, Kathmandu, Nepal, from April 2014 to September 2014. A total of 88 culture positive clinical samples (83 pulmonary and 5 extra-pulmonary) received during the study period were analyzed for detection of multidrug-resistant tuberculosis by both GeneXpert MTB/RIF assay and conventional DST method...
2017: PloS One
https://www.readbyqxmd.com/read/28060846/prediction-of-under-detection-of-paediatric-tuberculosis-in-the-democratic-republic-of-congo-experience-of-six-years-in-the-south-kivu-province
#15
Emmanuel André, Yvette Lufungulo Bahati, Eric Mulume Musafiri, Olivier Bahati Rusumba, Dimitri Van der Linden, Francis Zech
INTRODUCTION: In the field of tuberculosis (TB), and particularly in regard to paediatric TB (PedTB), clinical skills of health professionals play an important role in determining quality of care. In an era where novel diagnostic technologies and efficient treatment regimens are being made available for the poorest, we must not divert our attention from the importance of clinical skills, as this deliverable remains the cornerstone of individualized patient care and ultimately the best assurance for optimal use of resources...
2017: PloS One
https://www.readbyqxmd.com/read/28058538/factors-influencing-the-choice-of-first-and-second-line-biologic-therapy-for-the-treatment-of-rheumatoid-arthritis-real-life-data-from-the-italian-lorhen-registry
#16
Sara Monti, Catherine Klersy, Roberto Gorla, Piercarlo Sarzi-Puttini, Fabiola Atzeni, Raffaele Pellerito, Enrico Fusaro, Giuseppe Paolazzi, Pier Andrea Rocchetta, Ennio Giulio Favalli, Antonio Marchesoni, Roberto Caporali
According to international recommendations, the selection of the biologic disease modifying anti-rheumatic drug (bDMARD) for rheumatoid arthritis (RA) is mainly left to the clinician's preference. We analyzed the real-life factors influencing the first-line choice or the switching strategy, focusing on the prescription of abatacept (ABA) or tocilizumab (TCZ) compared to TNFα inhibitors (TNFi). Patients enrolled in the Lombardy Rheumatology Network (LORHEN) Registry after January 1, 2010, when all considered bDMARD agents were available, were included...
January 5, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28057041/rifampicin-resistance-pattern-of-mycobacterium-tuberculosis-and-associated-factors-among-presumptive-tuberculosis-patients-referred-to-debre-markos-referral-hospital-ethiopia-a-cross-sectional-study
#17
Wondemagegn Mulu, Bayeh Abera, Mulat Yimer, Tadesse Hailu, Haimanot Ayele, Dereje Abate
BACKGROUND: Prevailing data on rifampicin-resistant M. tuberculosis is essential for early management of MDR-TB. Therefore, this study was conducted to determine the prevalence of rifampicin-resistant Mycobacterium tuberculosis and associated factors among presumptive TB cases in Debre Markos Referral Hospital, Ethiopia. METHODS: A cross-sectional study was conducted from September 2014 to March 2015. Detection of M. tuberculosis and resistance to rifampicin was performed using Gene Xpert MTB/RIF assay...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28050442/pancreatic-tuberculosis-a-puzzle-for-physicians-a-rare-case-and-review-of-literature
#18
Prashanth Ashok Kumar, Gursharan Singh, John Biku Joseph, S Swaminathan, L Venkatakrishnan
Pancreatic Tuberculosis is an uncommon form of extra pulmonary tuberculosis that resembles malignancy of pancreas and serve as a diagnostic challenge for physicians. Conservative management with Anti Tuberculosis Therapy (ATT) will suffice for pancreatic tuberculosis whereas a malignancy may require major surgeries which may lead to significant morbidity. Here, we discuss the case of a female patient who presented with abdominal pain and vomiting and is a known case of chronic calcific pancreatitis. Radiological findings were that of malignancy of the pancreas...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28043613/emotional-distress-patients-with-several-types-of-tuberculosis-a-pilot-study-with-patients-from-the-sanatorium-hospital-of-huambo
#19
Benvinda Xavier Paulo, Bruno Peixoto
BACKGROUND: There is growing evidence that emotional distress expressed in terms of anxiety and depression it is very high among tuberculosis (TB) patients. OBJECTIVES: This study aims to determine levels of anxiety, depression and emotional distress in patients with several types of TB and to determine the association between social-demographic and economical factors, clinical variables and anxiety, depression and emotional distress. METHODS: A cross-sectional study was performed in a sample of 81 TB patients...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043552/role-of-socio-demographical-factors-on-tuberculosis-outcome-in-yemen
#20
Ammar Ali Saleh Jaber, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Nafees Ahmad
OBJECTIVES: Tuberculosis (TB) is an infection disease caused by an organism called Mycobacterium tuberculosis (tubercle bacilli). Tuberculosis remains the most common infection worldwide (Organization & World Health Organization, 2013). Yemen situated in WHO Eastern Mediterranean Region and ranked as intermediate TB-burdened countries. TB considers as one of the main health problems; it ranks as the fourth in the priority of the public health issue (NTCP, 2010). The study was conducted to evaluate the Socio-Demographical variables on tuberculosis treatment outcome...
December 2016: International Journal of Mycobacteriology
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