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https://www.readbyqxmd.com/read/28823130/use-of-alternative-curing-salts-for-processing-salamis
#1
Dong-Gyun Yim, Ku-Young Chung, Cheorun Jo, Ki-Chang Nam
Objective: This study was performed to determine effects of different curing salts on the quality of salamis and to assess feasibility of using NaCl-alternative salts. Methods: Various types of curing salts (KCl or MgCl2) as well as NaCl (sun-dried or refined) were incorporated for processing of salamis. The proximate composition, fatty acids, nucleotide-related compounds, and free amino acids of the salamis were analyzed during 40 days of ripening. Results: The substitution of NaCl by KCl caused higher fat and ash content, but lower moisture content of the salami after 20 days of ripening (p<0...
August 16, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28823085/chromaffin-cells-as-a-model-to-evaluate-mechanisms-of-cell-death-and-neuroprotective-compounds
#2
REVIEW
Cristobal de Los Rios, Maria F Cano-Abad, Mercedes Villarroya, Manuela G López
In this review, we show how chromaffin cells have contributed to evaluate neuroprotective compounds with diverse mechanisms of action. Chromaffin cells are considered paraneurons, as they share many common features with neurons: (i) they synthesize, store, and release neurotransmitters upon stimulation and (ii) they express voltage-dependent calcium, sodium, and potassium channels, in addition to a wide variety of receptors. All these characteristics, together with the fact that primary cultures from bovine adrenal glands or chromaffin cells from the tumor pheochromocytoma cell line PC12 are easy to culture, make them an ideal model to study neurotoxic mechanisms and neuroprotective drugs...
August 19, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28823078/sesquiterpenes-from-fruits-of-torilis-japonica-with-inhibitory-activity-on-melanin-synthesis-in-b16-cells
#3
Da Hye Song, Yang Hee Jo, Jong Hoon Ahn, Seon Beom Kim, Cheong-Yong Yun, Youngsoo Kim, Bang Yeon Hwang, Mi Kyeong Lee
Melanin, a dark macromolecular pigment, protects skin from harmful damage. However, abnormal accumulation is responsible for hyperpigmentation disorders. Melanogenesis inhibitors have therefore become important constituents in cosmetic products for depigmentation. Torilis japonica Decandolle (Umbelliferae) is a biennial plant which is distributed in East Asia. Fruits of this plant have been used for the treatment of skin disease and inflammation. In our previous study, torilin, a major sesquiterpene of T. japonica, showed an inhibitory effect on melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells...
August 19, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28823058/polyurethane-gelatin-nanofibrils-neural-guidance-conduit-containing-platelet-rich-plasma-and-melatonin-for-transplantation-of-schwann-cells
#4
Majid Salehi, Mahdi Naseri-Nosar, Somayeh Ebrahimi-Barough, Mohammdreza Nourani, Arash Khojasteh, Saeed Farzamfar, Korosh Mansouri, Jafar Ai
The current study aimed to enhance the efficacy of peripheral nerve regeneration using a biodegradable porous neural guidance conduit as a carrier to transplant allogeneic Schwann cells (SCs). The conduit was prepared from polyurethane (PU) and gelatin nanofibrils (GNFs) using thermally induced phase separation technique and filled with melatonin (MLT) and platelet-rich plasma (PRP). The prepared conduit had the porosity of 87.17 ± 1.89%, the contact angle of 78.17 ± 5.30° and the ultimate tensile strength and Young's modulus of 5...
August 19, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28823019/sensitive-and-selective-turn-on-chemodosimetric-probes-for-fe-3-based-on-a-skeleton-of-2-hydroxy-1-naphthaldehyde
#5
Ghulam Shabir, Aamer Saeed, Pervaiz Ali Channar, Fayaz Ali Larik, Tanzeela AbdulFatah
A naked-eye colored chemodosimeteric probes 4a-f, based on Schiff-azo dye conjugates were synthesized and characterized. All compounds 4a-f exhibited excellent selectivity and high sensitivity in absorbance toward detection of Fe(3+) in alcoholic solutions under neutral pH conditions. The detection limit of the probe was shown to be up to 0.05 ppm. A simple paper test strip system for the rapid monitoring of Fe(3+) was developed, indicating their convenient use in environmental samples. Electrochemical analysis of metal free conjugates and iron chelated probes confirmed the chelation of ligands...
August 19, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28823016/de-novo-synthesis-of-linoleic-acid-in-multiple-collembola-species
#6
Miriama Malcicka, Joachim Ruther, Jacintha Ellers
Many ecological interactions in communities take place between consumers and the organisms they feed on. Continuous surplus of specific nutritional compounds in the diet may lead to evolutionary changes in the metabolic capacity of the consumer, leaving the biosynthesis of such compounds prone to genetic decay and render organisms auxotrophic. A nutrient that is essential to many organisms is the unsaturated fatty acid, linoleic acid (LA; 18:2n-6), which is important in the maintenance of cell membrane fluidity and as a precursor for signaling molecules...
August 19, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28822990/%C3%AE-%C3%AE-mangostins-induces-autophagy-and-shows-synergistic-effectwith-gemcitabine-in-pancreatic-cancer-cell-lines
#7
Myoungjae Kim, Young-Won Chin, Eun Joo Lee
Pancreatic cancer is one of the most lethal and aggressive cancers in the world. However, no effective treatment is currently available for pancreatic cancer. The objective of this study was to determine the anti-pancreatic cancer effect of α-mangostin (αM) and γ-mangostin (γM) extracted from the pericarp of Garcinia mangostana L.. Both αM and γM reduced the viability of pancreatic cancer cells MIA PaCa-2 and PANC-1 in a dose-dependent manner. These compounds induced apoptosis by increasing c-PARP and c-Caspase 3 levels...
August 21, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28822987/effects-of-a-water-extract-of-lepidium-meyenii-root-in-different-models-of-persistent-pain-in-rats
#8
Barbara Tenci, Lorenzo Di Cesare Mannelli, Mario Maresca, Laura Micheli, Giuseppe Pieraccini, Nadia Mulinacci, Carla Ghelardini
Lepidium meyenii (Walp.), commonly called maca, is an Andean crop belonging to the Brassicaceae family. Maca hypocotils are habitually consumed as customary food as well as traditional remedies for pathological conditions such as infertility. Moreover, the characterization of maca extracts revealed the presence of compounds that are able to modulate the nervous system. Aimed to evaluate the efficacy of L. meyenii in persistent pain, the present study analyzed the effects of a commercial root extract from maca in different animal models reproducing the most common causes of chronic painful pathologies...
August 21, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28822930/spatial-and-temporal-patterns-of-pesticide-concentrations-in-streamflow-drainage-and-runoff-in-a-small-swedish-agricultural-catchment
#9
Maria Sandin, Kristin Piikki, Nicholas Jarvis, Mats Larsbo, Kevin Bishop, Jenny Kreuger
A better understanding of the dominant source areas and transport pathways of pesticide losses to surface water is needed for targeting mitigation efforts in a more cost-effective way. To this end, we monitored pesticides in surface water in an agricultural catchment typical of one of the main crop production regions in Sweden. Three small sub-catchments (88-242ha) were selected for water sampling based on a high-resolution digital soil map developed from proximal sensing methods and soil sampling; one sub-catchment had a high proportion of clay soils, another was dominated by coarse sandy soils while the third comprised a mix of soil types...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822764/effect-of-nitric-oxide-releasing-derivative-of-indomethacin-on-prevotella-intermedia-lipopolysaccharide-induced-production-of-proinflammatory-mediators-in-murine-macrophages
#10
So-Hui Choe, Eun-Young Choi, Jin-Yi Hyeon, In Soon Choi, Sung-Jo Kim
The purpose of this study was to investigate the influences of NCX 2121, a nitric oxide (NO)-releasing derivative of indomethacin, upon the generation of proinflammatory mediators using murine macrophages activated by lipopolysaccharide (LPS) isolated from Prevotella intermedia, which is one of the pathogens implicated in periodontal diseases. Inducible NO synthase (iNOS)-derived NO, IL-1β and IL-6 as well as their relevant mRNA were significantly attenuated by NCX 2121 in RAW264.7 cells activated by P. intermedia LPS...
August 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28822705/anti-dermatophyte-activity-of-leguminosae-plants-from-southern-brazil-with-emphasis-on-mimosa-pigra-leguminosae
#11
C B de Morais, M Scopel, G P R Pedrazza, F K da Silva, D F Dalla Lana, M L Tonello, S T S Miotto, M M Machado, L F S De Oliveira, A M Fuentefria, J A S Zuanazzi
BACKGROUND: Intensive prophylactic use of antifungals leads to the increase of drug resistance and the need for new and more effective treatments are real. Plants from Leguminosae family are rich in flavonoids, for which numerous biological activities have been described, including antifungal effects. PURPOSE: To screen methanolic extracts from Leguminosae species looking for alternative sources for antifungal agents (anti-dermatophyte and anti-Candida) and their innocuity...
August 16, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28822685/28-homocastasterone-down-regulates-blood-glucose-cholesterol-triglycerides-srebp1c-and-activates-lxr-expression-in-normal-diabetic-male-rat
#12
Velan Athithan, Kotteazeth Srikumar
Plant steroids are being recognized as influential secondary bio factors, assimilating in animal tissues through diet and affecting their cellular metabolic function to varying degree. They modulate catalytic and signaling functions in mammalian cells, affecting cellular homeostasis. The effect of phyto brassinosteroid ketoisoform 28-homocastasterone (28-HC), was assessed for its influence on blood glucose, plasma lipid and selective signal marker levels in normal and diabetic male wistar rat models. A 15 day oral feed regimen employing the experimental rat, noted that circulating blood glucose, cholesterol and triglyceride level in diabetic rat were markedly reduced by this compound...
August 16, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28822490/the-role-of-disease-in-bee-foraging-ecology
#13
REVIEW
Hauke Koch, Mark Jf Brown, Philip C Stevenson
Diseases have important but understudied effects on bee foraging ecology. Bees transmit and contract diseases on flowers, but floral traits including plant volatiles and inflorescence architecture may affect transmission. Diseases spill over from managed or invasive pollinators to native wild bee species, and impacts of emerging diseases are of particular concern, threatening pollinator populations and pollination services. Here we review how parasites can alter the foraging behaviour of bees by changing floral preferences and impairing foraging efficiency...
June 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28822486/adaptation-to-toxic-hosts-as-a-factor-in-the-evolution-of-insecticide-resistance
#14
REVIEW
Andrei Alyokhin, Yolanda H Chen
Insecticide resistance is a serious economic problem that jeopardizes sustainability of chemical control of herbivorous insects and related arthropods. It can be viewed as a specific case of adaptation to toxic chemicals, which has been driven in large part, but not exclusively, by the necessity for insect pests to tolerate defensive compounds produced by their host plants. Synthetic insecticides may simply change expression of specific sets of detoxification genes that have evolved due to ancestral associations with host plants...
June 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28822347/screening-and-confirmation-of-steroids-and-nitroimidazoles-in-urine-blood-and-food-matrices-sample-preparation-methods-and-liquid-chromatography-tandem-mass-spectrometric-separations
#15
Ádám Tölgyesi, Enikő Barta, Andrea Simon, Thomas J McDonald, Virender K Sharma
Veterinary drugs containing synthetic anabolic steroid and nitroimidazole active agents are not allowed for their applications in livestock of the European Union (EU). This paper presents analyses of twelve selected steroids and six nitroimidazole antibiotics at low levels (1.56μg/L-4.95μg/L and 0.17μg/kg-2.14μg/kg, respectively) in body fluids and egg incurred samples. Analyses involved clean-up procedures, high performance liquid chromatography (HPLC) separation, and tandem mass spectrometric screening and confirmatory methods...
August 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28822320/bio-active-maneonenes-and-isomaneonene-from-the-red-alga-laurencia-obtusa
#16
Nahed O Bawakid, Walied M Alarif, Ali I Ismail, Mohamed E El-Hefnawy, Khalid O Al-Footy, Sultan S Al-Lihaibi
Three previously undescribed compounds, maneonenes and isomaneonene derivatives; in addition to five known compounds, two cuparene, one chamigrene, and two cis-maneonenes were isolated from the Red Sea red alga Laurencia obtusa. The chemical structures of all unknown metabolites were characterized employing spectroscopic methods and then were further confirmed by single crystal X-ray analysis. Jeddahenyne A has C-5-C-12 etheric linkage and C-13-C-14 carbon-carbon double bond; Jeddahenyne B has in addition to the aforementioned etheric linkage a C-13 carbonyl function and absence of halogenation, unusual features for the maneonenes while 12-debromo-12-methoxy isomaneonene A shows unrecorded methoxylation at C-12...
August 16, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28822319/idesia-polycarpa-salicaceae-leaf-constituents-and-their-toxic-effect-on-cerura-vinula-and-lymantria-dispar-lepidoptera-larvae
#17
Felix Feistel, Christian Paetz, Sybille Lorenz, Franziska Beran, Grit Kunert, Bernd Schneider
Phytochemical investigation of Idesia polycarpa (Salicaceae) resulted in the structure elucidation of nine previously undescribed phenolic natural products along with six known compounds. The compounds are structurally related to salicinoids that are known defense compounds from Salix and Populus species. The I. polycarpa diet was toxic, as shown in feeding experiments with larvae of Lymantria dispar, an herbivorous broadleaf tree generalist insect, and with larvae of Cerura vinula, a specialist adapted to poplar...
August 16, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28822290/freeze-dryable-lipid-vesicles-with-size-tunability-and-high-encapsulation-efficiency-prepared-by-the-multiple-emulsification-solvent-evaporation-method
#18
Akihiko Suzuki, Takashi Kuroiwa, Kaname Horikoshi, Akihiko Kanazawa, Sosaku Ichikawa
We investigated the extent of potential applicability of our recently developed method for preparing lipid vesicles [T. Kuroiwa et al., J. Am. Oil Chem. Soc., 93 (2016) 421], designated as the multiple emulsification-solvent evaporation method, with the intention of controlling the vesicle diameter and achieving high entrapment efficiency for water-soluble compounds. Using this method, the diameter of lipid vesicles could be varied by selecting the methods for preparing the primary water-in-oil emulsion, which contained water droplets as templates for the internal water phases of lipid vesicles...
August 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28822281/an-integrative-study-to-identify-novel-scaffolds-for-sphingosine-kinase-1-inhibitors
#19
Marcela Vettorazzi, Emilio Angelina, Santiago Lima, Tomas Gonec, Jan Otevrel, Pavlina Marvanova, Tereza Padrtova, Petr Mokry, Pavel Bobal, Lina M Acosta, Alirio Palma, Justo Cobo, Janette Bobalova, Jozef Csollei, Ivan Malik, Sergio Alvarez, Sarah Spiegel, Josef Jampilek, Ricardo D Enriz
Sphingosine kinase 1 (SphK1), the enzyme that produces the bioactive sphingolipid metabolite, sphingosine-1-phosphate, is a promising new molecular target for therapeutic intervention in cancer and inflammatory diseases. In view of its importance, the main objective of this work was to find new and more potent inhibitors for this enzyme possessing different structural scaffolds than those of the known inhibitors. Our theoretical and experimental study has allowed us to identify two new structural scaffolds (three new compounds), which could be used as starting structures for the design and then the development of new inhibitors of SphK1...
August 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28822260/bioavailability-and-chronic-toxicity-of-bismuth-citrate-to-earthworm-eisenia-andrei-exposed-to-natural-sandy-soil
#20
Zohra Omouri, Jalal Hawari, Michel Fournier, Pierre Yves Robidoux
The present study describes bioavailability and chronic effects of bismuth to earthworms Eisenia andrei using OECD reproduction test. Adult earthworms were exposed to natural sandy soil contaminated artificially by bismuth citrate. Average total concentrations of bismuth in soil recovered by HNO3 digestion ranged from 75 to 289mg/kg. Results indicate that bismuth decreased significantly all reproduction parameters of Eisenia andrei at concentrations ≥ 116mg/kg. However, number of hatched cocoons and number of juveniles seem to be more sensitive than total number of cocoons, as determined by IC50; i...
August 16, 2017: Ecotoxicology and Environmental Safety
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