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https://www.readbyqxmd.com/read/29228398/organophosphorus-compounds-at-80-some-old-and-new-issues
#1
Lucio G Costa
One of the major classes of pesticides is that of the organophosphates (OPs). Initial developments date back almost two centuries but it was only in the mid-1940s that OPs reached a prominent status as insecticides, a status that, albeit declining, is still ongoing. OPs are highly toxic to non-target species including humans, the primary effects being an acute cholinergic toxicity (responsible for thousands of poisoning each year) and a delayed polyneuropathy. Several issues of current debate and investigation on the toxicology of OPs are discussed in this brief review...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29228374/quantitative-trait-loci-mapping-of-western-corn-rootworm-coleoptera-chrysomelidae-host-plant-resistance-in-two-populations-of-doubled-haploid-lines-in-maize-zea-mays-l
#2
Martin O Bohn, Juan J Marroquin, Sherry Flint-Garcia, Kenton Dashiell, David B Willmot, Bruce E Hibbard
Over the last 70 yr, more than 12,000 maize accessions have been screened for their level of resistance to western corn rootworm, Diabrotica virgifera virgifera (LeConte; Coleoptera: Chrysomelidae), larval feeding. Less than 1% of this germplasm was selected for initiating recurrent selection or other breeding programs. Selected genotypes were mostly characterized by large root systems and superior root regrowth after root damage caused by western corn rootworm larvae. However, no hybrids claiming native (i...
December 8, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29228347/exposure-of-mice-to-1-2-dichloropropane-induces-cyp450-dependent-proliferation-and-apoptosis-of-cholangiocytes
#3
Xiao Zhang, Cai Zong, Lingyi Zhang, Edwin Garner, Shigeyuki Sugie, Chinyen Huang, Wenting Wu, Jie Chang, Toshihiro Sakurai, Masashi Kato, Sahoko Ichihara, Shinji Kumagai, Gaku Ichihara
1, 2-Dichloropropane (1, 2-DCP) has been used as a paint remover in the industry. The International Agency for Research on Cancer reclassified this compound recently to Group 1 (carcinogenic to humans) based on epidemiological studies of cholangiocarcinoma among offset-color proof-printing workers exposed to 1, 2-DCP in Japan. Two-year rodent carcinogenicity bioassays demonstrated that 1, 2-DCP induced tumors in liver and lung, but not in bile duct. The present study was designed to assess the toxic effects of 1, 2-DCP on proliferation and apoptosis in mice bile duct and the role of cytochrome P450 (CYP450) in any such effect...
December 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29228308/rxr%C3%AE-enriched-cancer-stem-cell-like-properties-triggered-by-cddp-in-head-and-neck-squamous-cell-carcinoma-hnscc
#4
Pan Jiang, Chaoqi Xu, Ming Zhou, Huaqun Zhou, Weida Dong, Xiaoyue Wu, Aochang Chen, Qing Feng
Retinoid X receptor-α (RXRα) is a kind of nuclear receptor and is a target of cancer prevention and treatment in various types of cancers. Cancer stem cells (CSCs) are regarded as the main cause of carcinoma metastasis, tumor recurrence and chemotherapy resistance. So far, the mechanism how RXRα regulates CSCs remains unknown. In the present study, we found that RXRα was up-regulated in head and neck squamous cell carcinoma (HNSCC) tissues and the enriched HNSCC cancer stem cells. Over-expression of RXRα was able to expand the CSC-like properties in HNSCC cells, while knockdown of RXRα could repress the stemness respectively...
December 6, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29228303/identifying-possible-pheromones-of-cerambycid-beetles-by-field-testing-known-pheromone-components-in-four-widely-separated-regions-of-the-united-states
#5
Jocelyn G Millar, Robert F Mitchell, Judith A Mongold-Diers, Yunfan Zou, Carlos E Bográn, Melissa K Fierke, Matthew D Ginzel, Crawford W Johnson, James R Meeker, Therese M Poland, Iral Ragenovich, Lawrence M Hanks
The pheromone components of many cerambycid beetles appear to be broadly shared among related species, including species native to different regions of the world. This apparent conservation of pheromone structures within the family suggests that field trials of common pheromone components could be used as a means of attracting multiple species, which then could be targeted for full identification of their pheromones. Here, we describe the results of such field trials that were conducted in nine states in the northeastern, midwestern, southern, and western United States...
December 8, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29228244/prokaryote-composition-and-predicted-metagenomic-content-of-two-cinachyrella-morphospecies-and-water-from-west-papuan-marine-lakes
#6
D F R Cleary, A R M Polónia, N J de Voogd
Certain sponge species are difficult to identify using traditional morphology and other techniques are often necessary. Here we used 454-pyrosequencing of the 16S rRNA gene to investigate bacterial and archaeal communities of two distinct Cinachyrella morphospecies collected from two Indonesian marine lakes with differing degrees of connection to the surrounding sea. Our main goal was to assess whether these morphospecies hosted distinct bacterial and archaeal communities and to what extent these differed from those found in lake water...
December 5, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29228118/where-is-the-tmt-gc-ms-analyses-of-fox-feces-and-behavioral-responses-of-rats-to-fear-inducing-odors
#7
Olivier Rampin, Nathalie Jerôme, Audrey Saint-Albin, Christian Ouali, Frank Boué, Nicolas Meunier, Birte L Nielsen
TMT (2,5-dihydro-2,4,5-trimethylthiazoline) is known as a component of fox feces inducing fear in rodents. However, no recent chemical analyses of fox feces are available, and few studies make direct comparisons between TMT and fox feces. Fox feces from 3 individuals were used to prepare 24 samples to be analyzed for the presence of TMT using gas chromatography-mass spectrometry (GC-MS). When TMT was added in low amounts (50-2000 nmol/g), TMT was detected in 10 out of 11 samples. When no TMT was added, TMT was detected in only 1 out of 13 samples...
December 8, 2017: Chemical Senses
https://www.readbyqxmd.com/read/29228113/fibroblast-growth-factor-2-and-transforming-growth-factor-beta1-oppositely-regulate-mir-221-that-targets-thrombospondin-1-in-bovine-luteal-endothelial-cells
#8
Svetlana Farberov, Rina Meidan
Thrombospondin-1 (THBS1) is an important mediator of corpus luteum (CL) regression. Highly induced during luteolysis, it acts as a natural anti-angiogenic, proapoptotic compound. THBS1 expression is regulated in bovine luteal endothelial cells (LECs) by fibroblast growth factor-2 (FGF2) and transforming growth factor-beta1 (TGFB1) acting in an opposite manner. In this study we sought to identify specific microRNAs (miRNAs) targeting THBS1 and investigate their possible involvement in FGF2 and TGFB1-mediated THBS1 expression...
December 6, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29228071/associations-between-tau-%C3%AE-amyloid-and-cognition-in-parkinson-disease
#9
Joseph R Winer, Anne Maass, Peter Pressman, Jordan Stiver, Daniel R Schonhaut, Suzanne L Baker, Joel Kramer, Gil D Rabinovici, William J Jagust
Importance: Multiple disease processes are associated with cognitive impairment in Parkinson disease (PD), including Lewy bodies, cerebrovascular disease, and Alzheimer disease. It remains unknown whether tau pathology relates to cognition in patients with PD without dementia. Objective: To compare tau aggregation in patients with PD who are cognitively normal (PD-CN), patients with PD with mild cognitive impairment (PD-MCI), and healthy control participants, and evaluate the relationships between β-amyloid (Aβ), tau, and cognition in patients with PD who did not have dementia...
December 11, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29228015/development-of-an-iron-selective-antioxidant-probe-with-protective-effects-on-neuronal-function
#10
Olimpo García-Beltrán, Natalia P Mena, Pabla Aguirre, Germán Barriga-González, Antonio Galdámez, Edgar Nagles, Tatiana Adasme, Cecilia Hidalgo, Marco T Núñez
Iron accumulation, oxidative stress and calcium signaling dysregulation are common pathognomonic signs of several neurodegenerative diseases, including Parkinson´s and Alzheimer's diseases, Friedreich ataxia and Huntington's disease. Given their therapeutic potential, the identification of multifunctional compounds that suppress these damaging features is highly desirable. Here, we report the synthesis and characterization of N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetamide, named CT51, which exhibited potent free radical neutralizing activity both in vitro and in cells...
2017: PloS One
https://www.readbyqxmd.com/read/29227956/different-%C3%AE-alanine-dimeric-forms-in-trifluoromethanesulfonic-acid-salts-xrd-and-vibrational-studies
#11
Łukasz Wołoszyn, Maria M Ilczyszyn
Two new crystalline salts: β-alaninium trifluoromethanesulfonate (β-AlaOTf) and bis(β-alanine) trifluoromethanesulfonate (β-2AlaOTf) were obtained. The former one contains diprotonated β-alanine dimer, the latter one monoprotonated β-alanine dimer. Both compounds were studied by single crystal XRD, vibrational (IR and Raman) spectroscopy and calorimetric method. The quantum-mechanical calculations (DFT/B3LYP/6-311++G(2d,2p)) for the diprotonated dimer were carried out. The β-AlaOTf salt crystallizes in the P1¯ space group of triclinic system (Z=2), the β-2AlaOTf in the P21/m space group of monoclinic system (Z=2)...
December 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29227952/public-health-risk-of-trace-metals-in-fresh-chicken-meat-products-on-the-food-markets-of-a-major-production-region-in-southern-china
#12
Yuanan Hu, Wenfeng Zhang, Gang Chen, Hefa Cheng, Shu Tao
Because most chickens are reared in intensive farms, where a range of feed additives are used routinely, concerns have been raised on the potential public health risk of chicken product consumption. This study was conducted to characterize the contents of trace metals in fresh chicken tissues (354 samples) on the food markets in Guangdong province of southern China, a major region of chicken production with heavy per capita chicken consumption, and to assess the public health risk from chronic dietary exposure to the trace metals through chicken consumption...
December 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29227934/gabaa-receptor-activity-modulating-piperine-analogs-in-vitro-metabolic-stability-metabolite-identification-cyp450-reaction-phenotyping-and-protein-binding
#13
Volha Zabela, Timm Hettich, Götz Schlotterbeck, Laurin Wimmer, Marko D Mihovilovic, Fabrice Guillet, Belkacem Bouaita, Bénédicte Shevchenko, Matthias Hamburger, Mouhssin Oufir
In a screening of natural products for allosteric modulators of GABAA receptors (γ-aminobutyric acid type A receptor), piperine was identified as a compound targeting a benzodiazepine-independent binding site. Given that piperine is also an activator of TRPV1 (transient receptor potential vanilloid type 1) receptors involved in pain signaling and thermoregulation, a series of piperine analogs were prepared in several cycles of structural optimization, with the aim of separating GABAA and TRPV1 activating properties...
December 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29227933/synthesis-biological-evaluation-and-metabolic-stability-of-phenazine-derivatives-as-antibacterial-agents
#14
Maddeboina Krishnaiah, Nathalia Rodrigues de Almeida, Venkatareddy Udumula, Zhongcheng Song, Yashpal Singh Chhonker, Mai M Abdelmoaty, Valter Aragao do Nascimento, Daryl J Murry, Martin Conda-Sheridan
Drug-resistant pathogens are a major cause of hospital- and community-associated bacterial infections in the United States and around the world. These infections are increasingly difficult to treat due to the development of antibiotic resistance and the formation of bacterial biofilms. In the paper, a series of phenazines were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive (methicillin resistant staphylococcus aureus, MRSA) and Gram negative (Escherichia coli, E. coli) bacteria...
November 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29227932/an-overview-of-natural-antimicrobials-role-in-food
#15
REVIEW
Aurelia Magdalena Pisoschi, Aneta Pop, Cecilia Georgescu, Violeta Turcuş, Neli Kinga Olah, Endre Mathe
The present paper aims to review the natural food preservatives with antimicrobial properties emphasizing their importance for the future of food manufacturing and consumers' health. The extraction procedures applied to natural antimicrobials will be considered, followed by the description of some natural preservatives' antimicrobial mechanism of action, including (i) membrane rupture with ATP-ase activity inhibition, (ii) leakage of essential biomolecules from the cell, (iii) disruption of the proton motive force and (iiii) enzyme inactivation...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29227931/synthesis-and-antibacterial-evaluation-of-novel-cationic-chalcone-derivatives-possessing-broad-spectrum-antibacterial-activity
#16
Wen-Chao Chu, Peng-Yan Bai, Zhao-Qing Yang, De-Yun Cui, Yong-Gang Hua, Yi Yang, Qian-Qian Yang, En Zhang, Shangshang Qin
There is an urgent need to identify new antibiotics with novel mechanisms that combat antibiotic resistant bacteria. Herein, a series of chalcone derivatives that mimic the essential properties of cationic antimicrobial peptides were designed and synthesized. Antibacterial activities against drug-sensitive bacteria, including Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Salmonella enterica, as well as clinical multiple drug resistant isolates of methicillin-resistant S. aureus (MRSA), KPC-2-producing and NDM-1-producing Carbapenem-resistant Enterobacteriaceae were evaluated...
December 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29227929/green-approach-for-the-synthesis-of-thiophenyl-pyrazoles-and-isoxazoles-by-adopting-1-3-dipolar-cycloaddition-methodology-and-their-antimicrobial-activity
#17
D V Sowmya, G Lakshmi Teja, A Padmaja, V Kamala Prasad, V Padmavathi
A variety of N-((1,3-diphenyl-5-aryl-1H-pyrazol-4-yl)sulfonyl)thiophene-2-carboxamides (7) and N-((5-aryl-3-phenylisoxazol-4-yl)sulfonyl)thiophene-2-carboxamides (8) were prepared from (E)-N-(arylethenesulfonyl)thiophene-2-carboxamides (4) adopting 1,3-dipolar cycloaddition of nitrile imines and nitrile oxides generated from araldehyde phenylhydrazones and araldoximes in the presence of iodosobenzene and CTAB followed by oxidation with I2 in DMSO. The compounds 4f, 7e, 7f, 8e and 8f showed potential antibacterial activity against B...
December 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29227927/new-insight-into-the-enhanced-visible-light-driven-photocatalytic-activity-of-pd-pdcl2-doped-bi2wo6-photocatalysts
#18
Xiangchao Meng, Hanna Qin, Zisheng Zhang
A bismuth-based compound, Bi2WO6, was successfully synthesized using a facile hydrothermal method. Aiming to improve its photocatalytic activity under visible light irradiation, Pd/PdCl2 was first doped onto the surface of Bi2WO6 via a photo-reduction method. The prepared Pd/PdCl2-Bi2WO6 samples were characterized based on crystal structures, chemical states, atomic compositions, and morphologies as well as photoabsorption properties. In the screening tests for photocatalytic activity, the 4% Pd-Bi2WO6 sample performed with the highest removal efficiency with respect to the degradation of phenol in wastewater...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29227918/synthesis-anti-inflammatory-p38%C3%AE-map-kinase-inhibitory-activities-and-molecular-docking-studies-of-quinoxaline-derivatives-containing-triazole-moiety
#19
Sana Tariq, Ozair Alam, Mohd Amir
A new series of 3-[2-(5-mercapto-4-phenyl-4H-1,2,4-traiazol-3-yl)ethyl] quinoxalin-2(1H)-one (5a-v) derivatives was synthesized and subjected to in vitro evaluation for anti-inflammatory activity (BSA anti-denaturation assay) and p38α MAPK inhibition. Few selected compounds (5a, 5e, 5f, 5g, 5h, 5l, 5q and 5u) were studied for their in vivo anti-inflammatory activity, ulcerogenicity and lipid peroxidation potential. Compounds 5e and 5f were found to be the most active in the series showing 83.45% and 84.15% anti-inflammatory activity respectively when compared to diclofenac sodium (83...
December 2, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29227917/design-synthesis-molecular-docking-of-new-lipophilic-acetamide-derivatives-affording-potential-anticancer-and-antimicrobial-agents
#20
Hany E A Ahmed, Saleh K Ihmaid, Abdelsattar M Omar, Ahmed M Shehata, Heba S Rateb, Mohammed F Zayed, Sahar Ahmed, Mahmoud M Elaasser
Fifteen new substituted N-2-(2-oxo-3-phenylquinoxalin-1(2H)-yl) acetamides 5a-f, 6a-f, and 8a-c were synthesized by reacting ethyl 2-(2-oxo-3-phenylquinoxalin-1(2H)-yl)acetate with various primary amines including benzylamines, sulfonamides, and amino acids. The in vitro antimicrobial screening of the target compounds was screened to assess their antibacterial and antifungal activity. As a result, seven compounds namely; 5a, 5c, 5d, 6a, 6c, 8b and 8c showed a promising broad spectrum antibacterial activity against both Gram-positive and Gram-negative strains...
December 2, 2017: Bioorganic Chemistry
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