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https://www.readbyqxmd.com/read/29050412/adaptive-response-to-exercise-of-fast-growing-and-slow-growing-chicken-strains-blood-oxidative-status-and-non-enzymatic-antioxidant-defense
#1
S Mattioli, A Dal Bosco, S Ruggeri, M Martino, L Moscati, C Pesca, C Castellini
The adaptation of chickens to free-range rearing systems mainly involves the locomotory behavior, which is very different in fast-growing (FG) and slow-growing (SG) strains. This study aimed to compare the effect of moderate locomotory activity (induced and prolonged) on the blood oxidative status in a slow-growing chicken strain with that in a fast-growing one. Thirty FG (Ross 308) birds and 30 SG (Hubbard) birds were divided into 2 groups for each strain and subjected to different treatments: no exercise (the control group [C]) and 1 h of walking at 4 km/h (the exercise group [E])...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050397/the-antimyotonic-effect-of-lamotrigine-in-non-dystrophic-myotonias-a-double-blind-randomized-study
#2
Grete Andersen, Gitte Hedermann, Nanna Witting, Morten Duno, Henning Andersen, John Vissing
Mexiletine is the only drug with proven effect for treatment of non-dystrophic myotonia, but mexiletine is expensive, has limited availability and several side effects. There is therefore a need to identify other pharmacological compounds that can alleviate myotonia in non-dystrophic myotonias. Like mexiletine, lamotrigine is a sodium channel blocker, but unlike mexiletine, lamotrigine is available, inexpensive, and well tolerated. We investigated the potential of using lamotrigine for treatment of myotonia in patients with non-dystrophic myotonias...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050394/cortical-neurons-and-networks-are-dormant-but-fully-responsive-during-isoelectric-brain-state
#3
Tristan Altwegg-Boussac, Adrien E Schramm, Jimena Ballestero, Fanny Grosselin, Mario Chavez, Sarah Lecas, Michel Baulac, Lionel Naccache, Sophie Demeret, Vincent Navarro, Séverine Mahon, Stéphane Charpier
A continuous isoelectric electroencephalogram reflects an interruption of endogenously-generated activity in cortical networks and systematically results in a complete dissolution of conscious processes. This electro-cerebral inactivity occurs during various brain disorders, including hypothermia, drug intoxication, long-lasting anoxia and brain trauma. It can also be induced in a therapeutic context, following the administration of high doses of barbiturate-derived compounds, to interrupt a hyper-refractory status epilepticus...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050302/2l-pca-a-two-level-principal-component-analyzer-for-quantitative-drug-design-and-its-applications
#4
Qi-Shi Du, Shu-Qing Wang, Neng-Zhong Xie, Qing-Yan Wang, Ri-Bo Huang, Kuo-Chen Chou
A two-level principal component predictor (2L-PCA) was proposed based on the principal component analysis (PCA) approach. It can be used to quantitatively analyze various compounds and peptides about their functions or potentials to become useful drugs. One level is for dealing with the physicochemical properties of drug molecules, while the other level is for dealing with their structural fragments. The predictor has the self-learning and feedback features to automatically improve its accuracy. It is anticipated that 2L-PCA will become a very useful tool for timely providing various useful clues during the process of drug development...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050284/mutational-analysis-of-a-chinese-family-with-oculocutaneous-albinism-type-2
#5
Xiong Wang, Yaowu Zhu, Na Shen, Jing Peng, Chunyu Wang, Haiyi Liu, Yanjun Lu
Oculocutaneous albinism (OCA) is an autosomal recessive disorder characterized by hypopigmentation of the skin, hair, and eyes accompanied with ophthalmologic abnormalities. Molecular genetic test can confirm the diagnosis of the four subtypes of OCA (OCA1-4). Herein, we report a Chinese family with two patients affected by OCA. Mutations of TYR, OCA2, TYRP1, and SLC45A2 were examined by using PCR-sequencing. Large deletions or duplications of TYR and OCA2 were examined by Multiplex Ligation-dependent Probe Amplification (MLPA) assay...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050265/reactive-oxygen-species-dependent-phosphorylation-of-the-liver-kinase-b1-amp-activated-protein-kinase-acetyl-coa-carboxylase-signaling-is-critically-involved-in-apoptotic-effect-of-lambertianic-acid-in-hepatocellular-carcinoma-cells
#6
Arong Jeong, Ju-Ha Kim, Hyo-Jung Lee, Sung-Hoon Kim
Though lambertianic acid (LA) is reported to have hypolipidemic activity in liver, its underlying anticancer mechanism is poorly understood so far. Thus, in the present study, apoptotic mechanism of LA was elucidated in HepG2 and SK-Hep1 hepatocellular carcinoma (HCC) cells. Here LA increased cytotoxicity, sub-G1 population and Annexin V/PI positive cells in two HCC cells. Also, LA cleaved caspase-3 and poly(ADP-ribose) polymerase (PARP), activated phosphorylation of liver kinase B1 (LKB1)/AMP activated protein kinase (AMPK)/ acetyl-CoA carboxylase (ACC) pathway and also suppressed antiapoptotic proteins such as phosphorylation of Akt/ mammalian target of rapamycin (mTOR) and the expression of B cell lymphoma-2 (Bcl-2)/ B-cell lymphoma-extra large (Bcl-xL) and cyclooxygenase-2 (COX-2) in two HCC cells...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050237/modulation-of-the-nur77-bcl-2-apoptotic-pathway-by-p38%C3%AE-mapk
#7
Jie Liu, Guang-Hui Wang, Ying-Hui Duan, Yi Dai, Yuzhou Bao, Mengjie Hu, Yu-Qi Zhou, Mingyu Li, Fuquan Jiang, Hu Zhou, Xin-Sheng Yao, Xiao-Kun Zhang
Orphan nuclear receptor Nur77 promotes apoptosis by targeting mitochondria through interaction with Bcl-2, an event that converts Bcl-2 from a survival to killer. However, how the Nur77-Bcl-2 apoptotic pathway is regulated remains largely unknown. In this study, we examined the regulation of the Nur77-Bcl-2 pathway by CCE9, a xanthone compound. Our results demonstrated that the apoptotic effect of CCE9 depended on its induction of Nur77 expression, cytoplasmic localization, and mitochondrial targeting. The activation of the Nur77-Bcl-2 pathway by CCE9 was associated with its activation of p38α MAPK...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050220/characterization-of-a-novel-androgen-receptor-ar-coregulator-ripk1-and-related-chemicals-that-suppress-ar-mediated-prostate-cancer-growth-via-peptide-and-chemical-screening
#8
Cheng-Lung Hsu, Jai-Shin Liu, Ting-Wei Lin, Ying-Hsu Chang, Yung-Chia Kuo, An-Chi Lin, Huei-Ju Ting, See-Tong Pang, Li-Yu Lee, Wen-Lung Ma, Chun-Cheng Lin, Wen-Guey Wu
Using bicalutamide-androgen receptor (AR) DNA binding domain-ligand binding domain as bait, we observed enrichment of FxxFY motif-containing peptides. Protein database searches revealed the presence of receptor-interacting protein kinase 1 (RIPK1) harboring one FxxFY motif. RIPK1 interacted directly with AR and suppressed AR transactivation in a dose-dependent manner. Domain mapping experiments showed that the FxxFY motif in RIPK1 is critical for interactions with AR and the death domain of RIPK1 plays a crucial role in its inhibitory effect on transactivation...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050157/-observation-of-clinical-and-electrophysiological-features-in-patients-with-distal-myasthenia-gravis
#9
F Jian, H B Wang, N Chen, S Yang, Y Liu, Y Z Zhao, L Zhang, H Pan, X H Zhang
Objective: To explore the clinical and electrophysiological features and prognosis of distal myasthenia gravis (MG). Methods: Data of MG patients in Beijing Tiantan Hospital from October 2016 to March 2017 were reviewed, including thorough neurological examinations, nerve conduction studies, repetitive nerve stimulations (RNS) and needle electromyographies. Distal MG patients were included and were analyzed as to their clinical and electrophysiological features and response to treatments. Results: Four patients (7...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29050027/new-preventive-approaches-part-ii-role-of-dentin-biomodifiers-in-caries-progression
#10
Ana K Bedran-Russo, Camila A Zamperini
Dental caries is the most prevalent infectious chronic disease in children and adults. With a globally aging population, new demands in the management of dental caries are awakened by the rampant increase in the incidence of dental root caries. Like crown caries, root caries requires bacterial driven tissue demineralization followed by the degradation of the extracellular dentin matrix. Due to the complex composition and ultrastructure, preventive strategies targeting the mineral phase of dentin are insufficient for managing the prevention and progression of root caries...
2017: Monographs in Oral Science
https://www.readbyqxmd.com/read/29049987/isoflavones-induce-bex2-dependent-autophagy-to-prevent-atr-induced-neurotoxicity-in-sh-sy5y-cells
#11
Peng Li, Kun Ma, Hao-Yu Wu, Yan-Ping Wu, Bai-Xiang Li
BACKGROUND/AIMS: Atrazine (ATR) is a broad-spectrum herbicide in wide use around the world. However, ATR is neurotoxic and can cause cell death in dopaminergic neurons, leading to neurodegenerative disorders. Autophagy is the basic cellular catabolic process involving the degradation of proteins and damaged organelles. Studies have shown that certain plant compounds can induce autophagy and prevent neuronal cell death. This prompted us to investigate plant compounds that might reduce the neurotoxic effects of ATR...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29049984/effect-of-thiobacillus-thioparus-1904-and-sulphur-addition-on-odour-emission-during-aerobic-composting
#12
Wenjie Gu, Wen Sun, Yusheng Lu, Xia Li, Peizhi Xu, Kaizhi Xie, Lili Sun, Hangtao Wu
The effects of sulphur and Thiobacillus thioparus 1904 on odour emissions during composting were studied. Results indicated that the sulphur addition reduced the pH and decreased cumulative emission of ammonia and the nitrogen loss by 47.80% and 44.23%, respectively, but the amount of volatile sulphur compounds (VSCs) and the sulphur loss increased. The addition of T. thioparus 1904 effectively reduced the cumulative emissions of H2S, methyl sulphide, methanethiol, dimethyl disulphide and the sulphur loss by 33...
October 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29049967/halogenated-fatty-amides-a-brand-new-class-of-disinfection-by-products
#13
Dmitry S Kosyakov, Nikolay V Ul'yanovskii, Mark S Popov, Tomas B Latkin, Albert T Lebedev
An array of similar halogenated nitrogen-containing compounds with elemental composition CnH2nNO2X, CnH2n-2NO2X and CnH2n-1NOX2 (X = Cl, Br; n = 16, 18, 22) was detected in drinking water with high performance liquid chromatography - high resolution mass spectrometry (HPLC-HRMS) method. Compounds of this type were never mentioned among disinfection by-products. Tandem mass spectrometry allowed referring them to halohydrines or dihalogenated fatty amides, the products of conjugated electrophilic addition of halogens to the double bonds of unsaturated fatty amides...
October 6, 2017: Water Research
https://www.readbyqxmd.com/read/29049963/optimization-of-physicochemical-properties-for-4-anilinoquinazoline-inhibitors-of-trypanosome-proliferation
#14
Jennifer L Woodring, Kelly A Bachovchin, Kimberly G Brady, Mitchell F Gallerstein, Jessey Erath, Scott Tanghe, Susan E Leed, Ana Rodriguez, Kojo Mensa-Wilmot, Richard J Sciotti, Michael P Pollastri
Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. We previously reported the discovery of 2 (NEU-617), a small molecule with activity against T. brucei bloodstream proliferation. Further optimization of 2 to improve the physicochemical properties (LogP, LLE, [1], and MPO score) [2] have led us to twelve sub-micromolar compounds, most importantly the headgroup variants 9i and 9j, and the linker variant 18. Although these 3 compounds had reduced potency compared to 2, they all had improved LogP, LLE and MPO scores...
October 6, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29049959/excretion-pattern-and-dynamics-of-glutathione-detoxification-of-microcystins-in-sprague-dawley-rat
#15
Wei Li, Jun He, Jun Chen, Ping Xie
The excretion route and dynamics of the glutathione (GSH) conjugate of microcystin-RR (MCRR), MCRR-GSH, were quantitatively studied in Sprague Dawley rat exposed with MCRR-GSH via liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS). In the MCRR-GSH-treated rat, the average MCRR-Cysteine (MCRR-Cys)/MCRR-GSH ratio reached as high as 105.3, which indicated that the intermediate conjugate MCRR-GSH was rapidly converted to the product compound MCRR-Cys. Besides, MCRR was consistently detected in MCRR-GSH-treated rat, which suggested that MCRR can be dissociated from the MCRR-GSH conjugate and the reversibility of the MC-GSH conjugate...
September 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/29049944/bioaccumulation-and-effects-of-novel-chlorinated-polyfluorinated-ether-sulfonate-in-freshwater-alga-scenedesmus-obliquus
#16
Wei Liu, Jingwen Li, Lichen Gao, Zhou Zhang, Jing Zhao, Xin He, Xin Zhang
Chlorinated polyfluorinated ether sulfonate (Cl-PFESA) is a novel alternative compound for perfluorooctane sulfonate (PFOS), with its environmental risk not well known. The bioaccumulation and toxic effects of Cl-PFESA in the freshwater alga is crucial for the understanding of its potential hazards to the aquatic environment. Scenedesmus obliquus was exposed to Cl-PFESA at ng L(-1) to mg L(-1), with the exposure regime beginning at the environmentally relevant level. The total log BAF of Cl-PFESA in S. obliquus was 4...
October 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29049943/occurrence-and-profile-of-organophosphorus-compounds-in-fine-and-coarse-particulate-matter-from-two-urban-areas-of-china-and-pakistan
#17
Yasir Faiz, Naila Siddique, Huan He, Cheng Sun, Shahida Waheed
Seven organophosphorus compounds (OPs) were measured in urban fine and coarse particulate matter (PM) collected from two sites of Nanjing (XCNUC), China and Islamabad (APHSP), Pakistan. The fine PM mass at APHSP site was significantly higher (p = 0.005) in the spring (mean 22.5 μg/m(3)) than in the summer (mean 12.7 μg/m(3)). The total concentration, ∑(7)OPs, of samples collected at APHSP was found significantly higher in coarse (range 672-47621 pg/m(3)) than in fine PM (range 1200-15213 pg/m(3)); while ∑(7)OPs from XCNUC in fine (range 1696-15063 pg/m(3)) and coarse PM (range 2053-5379 pg/m(3)) were statistically different in samples during summer, based on two-sample t-test at 0...
October 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29049940/photocatalytic-degradation-of-synthetic-food-dye-sunset-yellow-fcf-fd-c-yellow-no-6-by-ailanthus-excelsa-roxb-possessing-antioxidant-and-cytotoxic-activity
#18
Subramanyam Deepika, Rajendran Harishkumar, Murugesan Dinesh, Rajadurai Abarna, Moorthy Anbalagan, Selvaraj Mohana Roopan, Chinnadurai Immanuel Selvaraj
The purpose of our work is to identify the bioactive compounds of bark and leaves extract from Ailanthus excelsa Roxb. and to explore its effectiveness against synthetic food dye. The presence of primary and secondary metabolites was confirmed by carrying out phytochemicals analysis. With the prior knowledge accessible on the indispensable secondary metabolites holding antioxidant and cytotoxicity activity, the quantitative screening of total phenolic and flavonoid content in methanolic and aqueous extract of bark and leaves from Ailanthus excelsa were done...
October 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29049906/interaction-between-compound-genetic-risk-for-schizophrenia-and-high-birth-weight-contributes-to-social-anhedonia-and-schizophrenia-in-women
#19
Johanna Liuhanen, Jaana Suvisaari, Eero Kajantie, Jouko Miettunen, Antti-Pekka Sarin, Marjo-Riitta Järvelin, Jouko Lönnqvist, Juha Veijola, Tiina Paunio
Schizophrenia is a highly heritable disease, but despite extensive study, its genetic background remains unresolved. The lack of environmental measures in genetic studies may offer some explanation. In recent Finnish studies, high birth weight was found to increase the risk for familial schizophrenia. We examined the interaction between a polygenic risk score for schizophrenia and high birth weight on social anhedonia and schizophrenia in a general population birth cohort. The study sample included 4223 participants from the 1966 Northern Finland Birth Cohort...
October 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29049886/structure-activity-relationship-studies-of-pyrimido-5-4-b-indoles-as-selective-toll-like-receptor-4-ligands
#20
Michael Chan, Yuhei Kakitsubata, Tomoko Hayashi, Alast Ahmadi, Shiyin Yao, Nikunj M Shukla, Shin-Ya Oyama, Akihito Baba, Brandon Nguyen, Maripat Corr, Yasuo Suda, Dennis A Carson, Howard B Cottam, Masahiro Wakao
Previous high throughput screening studies led to the discovery of two novel, non-lipid-like chemotypes as Toll-like receptor 4 (TLR4) agonists. One of these chemotypes, the pyrimido[5,4-b]indoles, was explored for structure-activity relationship trends relative to production of TLR4 dependent cytokines/chemokines resulting in a semi-optimized lead (compound 1) that provided a starting point for further optimization studies. In this report, compounds belonging to three areas of structural modification were evaluated for biological activity using murine and human TLR4 reporter cells, primary murine bone marrow derived dendritic cells, and human peripheral blood mononuclear cells...
October 19, 2017: Journal of Medicinal Chemistry
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