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https://www.readbyqxmd.com/read/28096932/contemporary-agents-in-the-management-of-metastatic-castration-resistant-prostate-cancer
#1
REVIEW
Anil Kapoor, Christopher Wu, Bobby Shayegan, Adrian P Rybak
Docetaxel-based chemotherapy has been the standard of care for metastatic castration-resistant prostate cancer (mCRPC) since 2004. Over the past few years, there has been a significant paradigm shift in the treatment landscape of this disease. A deeper understanding of prostate cancer biology, along with the development of novel agents has created hope towards treating chemotherapy-naïve and resistant disease. Following the implementation of docetaxel as the first-line therapy for mCRPC, five novel therapies have demonstrated survival benefit in mCRPC...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28089364/the-impact-of-neoadjuvant-chemotherapy-on-skeletal-muscle-depletion-and-preoperative-sarcopenia-in-patients-with-resectable-colorectal-liver-metastases
#2
Sam Eriksson, Jan H Nilsson, Peter Strandberg Holka, Jakob Eberhard, Inger Keussen, Christian Sturesson
BACKGROUND: Preoperative skeletal muscle depletion or sarcopenia has been suggested to predict worse outcome after resection of colorectal liver metastases. The aim of the present study was to investigate the impact of neoadjuvant chemotherapy on preoperative skeletal muscle mass prior to liver resection. METHODS: Patients operated with liver resection for colorectal liver metastases between 2010 and 2014 were retrospectively reviewed. Muscle mass was evaluated by measuring muscle area on a cross-sectional computed tomography image at the level of the third lumbar vertebra, and normalized for patient height, presenting a skeletal muscle index...
January 11, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28088002/radiochemical-studies-pre-clinical-investigation-and-preliminary-clinical-evaluation-of-170-tm-edtmp-prepared-using-in-house-freeze-dried-edtmp-kit
#3
Tapas Das, Ajit Shinto, Koramadai K Kamaleshwaran, Haladhar D Sarma, Sahiralam Khan Mohammed, Arpit Mitra, Sangita Lad, M G R Rajan, Sharmila Banerjee
The objective of the present work is to formulate (170)Tm-EDTMP using an in-house freeze-dried EDTMP kit and evaluate its potential as a bone pain palliation agent. Patient dose of (170)Tm-EDTMP was prepared with high radiochemical purity using the lyophilized kit at room temperature within 15min. Pre-clinical evaluation in normal Wistar rats revealed selective skeletal accumulation with extended retention. Preliminary clinical investigation in 8 patients with disseminated skeletal metastases exhibited selective uptake in the bone and retention therein for a long duration...
January 5, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28072622/170tm-edtmp-a-prospective-alternative-of-89srcl2-for-theranostic-treatment-of-metastatic-bone-pain
#4
Tapas Das, Ajit Shinto, Koramadai Karuppuswamy Kamaleshwaran, Sharmila Banerjee
We have earlier reported the potential of Tm-EDTMP as an alternative cost-effective radiopharmaceutical of SrCl2 for bone pain palliation application. Encouraging results obtained in the radiochemical studies and biological evaluations in animal model have prompted us to initiate the clinical study to evaluate the potential of Tm-EDTMP in human cancer patients. The serial scintigraphic images represent the whole-body scans of a patient (68 years old woman) with skeletal metastases of carcinoma of the breast origin recorded after administering 370 MBq (10 mCi) of Tm-EDTMP at different post-administration time points along with the pre-therapy images recorded with Tc-MDP in the same patient...
January 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28050490/renal-cell-carcinoma-with-unusual-skeletal-metastasis-to-tibia-and-ankle-a-case-report-and-review-of-literature
#5
Kiran Shankar, Durgesh Kumar, Kariyanakatte Veeraiah Veerendra Kumar, Chennagiri Premlata
Renal Cell Carcinoma (RCC) accounts for 5% of the epithelial malignancies worldwide with clear cell carcinoma accounting for 85% of these malignancies. One third of these patients experience synchronous metastatic disease and 20-30% of the remaining patients experience metachronous metastatic RCC. Bony metastasis accounts for 20% of metastatic RCC. They most commonly affect the axial skeleton and rarely the long bones or the small bones of the hands and feet. Bone metastases from RCC are predominantly osteolytic in nature, leading to significant patient morbidity due to the associated Skeletal Related Events (SRE)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28047011/we-h-207a-05-spatial-co-localization-of-f-18-naf-vs-f-18-fdg-defined-disease-volumes
#6
P Ferjancic, S Harmon, S Chen, U Simoncic, R Jeraj
PURPOSE: Both [F-18]NaF and [F-18]FDG show promise for quantitative PET/CT assessment in metastatic prostate cancer to bone. Broad agreement between the tracers has been shown but voxel-wise correspondence has not been explored in depth. This study evaluates the spatial co-localization of [F-18]NaF PET and [F-18]FDG PET in bone lesions. METHODS: Seventy-three lesion contours were identified in six patients receiving dynamic NaF PET/CT and FDG PET/CT scans two hours apart using identical fields-of-view...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039445/aromatase-inhibitor-induced-bone-loss-increases-the-progression-of-estrogen-receptor-negative-breast-cancer-in-bone-and-exacerbates-muscle-weakness-in-vivo
#7
Laura E Wright, Ahmed A Harhash, Wende M Kozlow, David L Waning, Jenna N Regan, Yun She, Sutha K John, Sreemala Murthy, Maryla Niewolna, Andrew R Marks, Khalid S Mohammad, Theresa A Guise
Aromatase inhibitors (AIs) cause muscle weakness, bone loss, and joint pain in up to half of cancer patients. Preclinical studies have demonstrated that increased osteoclastic bone resorption can impair muscle contractility and prime the bone microenvironment to accelerate metastatic growth. We hypothesized that AI-induced bone loss could increase breast cancer progression in bone and exacerbate muscle weakness associated with bone metastases. Female athymic nude mice underwent ovariectomy (OVX) or sham surgery and were treated with vehicle or AI (letrozole; Let)...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/28030702/effect-of-longer-interval-vs-standard-dosing-of-zoledronic-acid-on-skeletal-events-in-patients-with-bone-metastases-a-randomized-clinical-trial
#8
Andrew L Himelstein, Jared C Foster, James L Khatcheressian, John D Roberts, Drew K Seisler, Paul J Novotny, Rui Qin, Ronald S Go, Stephen S Grubbs, Tracey O'Connor, Mario R Velasco, Douglas Weckstein, Ann O'Mara, Charles L Loprinzi, Charles L Shapiro
Importance: Zoledronic acid, a third-generation aminobisphosphonate, reduces the incidence of skeletal-related events and pain in patients with bone metastases. The optimal dosing interval for zoledronic acid is uncertain. Objective: To determine whether zoledronic acid administered every 12 weeks is noninferior to zoledronic acid administered every 4 weeks. Design, Setting, Participants: Randomized, open-label clinical trial conducted at 269 academic and community sites in the United States...
3, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28026865/factors-predicting-skeletal-related-events-in-patients-with-bone-metastatic-castration-resistant-prostate-cancer
#9
Zachary Klaassen, Lauren E Howard, Amanda de Hoedt, Christopher L Amling, William J Aronson, Matthew R Cooperberg, Christopher J Kane, Martha K Terris, Stephen J Freedland
BACKGROUND: Skeletal-related events (SREs) are common complications of bone metastatic castration-resistant prostate cancer (mCRPC). To the authors' knowledge, there are limited data regarding which factors predict SREs. The authors identified risk factors for SREs in men with bone mCRPC using characteristics commonly available in the medical record. METHODS: Data from 454 patients with nonmetastatic CRPC were identified from 2 Veteran Affairs Medical Centers from 2000 through 2013...
December 27, 2016: Cancer
https://www.readbyqxmd.com/read/28012435/estimation-of-radiation-dosimetry-for-68-ga-hbed-cc-psma-11-in-patients-with-suspected-recurrence-of-prostate-cancer
#10
Mark A Green, Jacob A Eitel, James W Fletcher, Carla J Mathias, Mark A Tann, Thomas Gardner, Michael O Koch, Wendy Territo, Heather Polson, Gary D Hutchins
INTRODUCTION: This study was performed to estimate the human radiation dosimetry for [(68)Ga]Ga-HBED-CC (PSMA-11) ((68)Ga PSMA-11). METHODS: Under an RDRC-approved research protocol, we evaluated the biodistribution and pharmacokinetics of (68)Ga PSMA-11 with serial PET imaging following intravenous administration to nine prostate cancer patients in whom clinical [(11)C]acetate PET/CT exams had been independently performed under Expanded Access IND 118,204. List-mode imaging was performed over the initial 0-10min post-injection with the pelvis in the field-of-view...
November 4, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28008381/pathologic-fracture-and-healthcare-resource-utilisation-a-retrospective-study-in-eight-european-countries
#11
Jean-Jacques Body, Yves Pascal Acklin, Oliver Gunther, Guy Hechmati, João Pereira, Nikos Maniadakis, Evangelos Terpos, Jindrich Finek, Roger von Moos, Susan Talbot, Harm Sleeboom
BACKGROUND: Skeletal-related events (SREs; pathologic fracture [PF], spinal cord compression and radiation or surgery to bone) are common complications of bone metastases or bone lesions and can impose a considerable burden on patients and healthcare systems. In this study, the healthcare resource utilisation (HRU) associated with PFs in patients with bone metastases or lesions secondary to solid tumours or multiple myeloma was estimated in eight European countries. METHODS: Eligible patients were identified in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland...
November 2016: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28008379/a-phase-2-trial-exploring-the-clinical-and-correlative-effects-of-combining-doxycycline-with-bone-targeted-therapy-in-patients-with-metastatic-breast-cancer
#12
C L Addison, D Simos, Z Wang, G Pond, S Smith, S Robertson, S Mazzarello, G Singh, L Vandermeer, R Fernandes, A Iyengar, S Verma, M Clemons
BACKGROUND: Bone-targeting agents (BTAs), such as bisphosphonates and denosumab, have demonstrated no discernable effects on tumour response or disease free/overall survival in patients with bone metastases from breast cancer. Doxycycline is both osteotropic and has anti-cancer effects. When combined with zoledronate in animal models, doxycycline showed significantly increased inhibition of tumour burden and increased bone formation. We evaluated the effects of adding doxycycline to ongoing anti-cancer therapy in patients with metastatic breast cancer...
November 2016: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28002240/longitudinal-computed-tomography-monitoring-of-pelvic-bones-in-patients-with-breast-cancer-using-automated-bone-subtraction-software
#13
Marius Horger, Wolfgang Maximilian Thaiss, Benjamin Wiesinger, Hendrik Ditt, Jan Fritz, Konstantin Nikolaou, Christopher Kloth
OBJECTIVE: The aim of this study was to optimize computed tomography (CT) surveillance of skeletal metastases in patients with breast cancer through the use of osseous subtraction maps between baseline and follow-up examinations created by a novel software algorithm. The new postprocessing algorithm segments the original bone followed by image intensity-based rigid alignment creating gray-shaded maps that highlight focal or diffuse loss or increase in bone attenuation. MATERIALS AND METHODS: Institutional review board was obtained for this retrospective data evaluation...
December 20, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27991924/cooperation-among-heterogeneous-prostate-cancer-cells-in-the-bone-metastatic-niche
#14
K Shahriari, F Shen, A Worrede-Mahdi, Q Liu, Y Gong, F U Garcia, A Fatatis
The growth of disseminated tumor cells into metastatic lesions depends on the establishment of a favorable microenvironment in the stroma of the target organs. Here we show that mice treated with anakinra, an antagonist of the interleukin (IL)-1β receptor (IL-1R), or harboring a targeted deletion of IL-1R are significantly less prone to develop bone tumors when inoculated in the arterial circulation with human prostate cancer (PCa) cells expressing IL-1β. Interestingly, human mesenchymal stem cells exposed in vitro to medium conditioned by IL-1β-expressing cancer cells responded by upregulating S100A4, a marker of cancer-associated fibroblasts (CAFs), and this effect was blocked by anakinra...
December 19, 2016: Oncogene
https://www.readbyqxmd.com/read/27990273/advances-in-the-management-of-osteosarcoma
#15
REVIEW
Stefan S Bielack, Stefanie Hecker-Nolting, Claudia Blattmann, Leo Kager
Osteosarcoma, a bone cancer most commonly seen in adolescents and young adults, is usually a high-grade malignancy characterized by a very high risk for the development of pulmonary metastases. High-grade osteosarcomas are usually treated by preoperative and postoperative chemotherapy and surgery, with a very limited number of active agents available. Rarer lower-grade variants such as parosteal and periosteal osteosarcoma or low-grade central osteosarcoma are treated by surgery only. Imaging to search for possible metastases focuses on the lung...
2016: F1000Research
https://www.readbyqxmd.com/read/27988895/radiopharmaceuticals-for-metastatic-bone-pain-palliation-available-options-in-the-clinical-domain-and-their-comparisons
#16
REVIEW
Tapas Das, Sharmila Banerjee
Bone pain arising due to skeletal metastases is one of the common complications experienced by the majority of patients suffering from prostate, breast and lung cancer at the advanced stage of the disease. These patients are subjected to palliative care in order to improve the quality of their remaining life. With the gradually increasing number of cancer cases, palliation of metastatic bone pain is gaining importance. Bone-seeking radiopharmaceuticals play a pivotal role in the management of cancer pain, particularly in patients with multiple metastases, as these agents are proven to be effective in controlling the bone pain with minimum side effects...
December 17, 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/27968915/dynamic-contrast-enhanced-mri-to-predict-response-to-vinorelbine-cisplatin-alone-or-with-rh-endostatin-in-patients-with-non-small-cell-lung-cancer-and-bone-metastases-a-randomised-double-blind-placebo-controlled-trial
#17
Rui Zhang, Zhi-Yu Wang, Yue-Hua Li, Yao-Hong Lu, Shuai Wang, Wen-Xi Yu, Hui Zhao
BACKGROUND: Metastatic bone disease is a frequent complication of advanced non-small-cell lung cancer and causes skeletal-related events which result in a poor prognosis. A standard method to assess the therapeutic response of bone metastases does not currently exist. We used dynamic contrast-enhanced MRI to obtain quantitative measures to assess the suitability of this technique to gauge therapeutic response to vinorelbine-cisplatin plus rh-endostatinfor previously untreated non-small cell lung cancer with bone metastases...
October 2016: Lancet
https://www.readbyqxmd.com/read/27968857/surgical-treatment-of-patients-with-lung-cancer-and-bone-metastases-a-prospective-observational-study
#18
Wang Zhiyu, Zhang Rui, Wang Shuai, Zhao Hui
BACKGROUND: As life expectancy improves in patients with lung cancer and bone metastases, effective surgical treatment to relieve pain and improve quality of life and neurological function is increasingly needed. Indications for surgery in patients with bone metastases are controversial. We aimed to assess a protocol for the surgery of patients with lung cancer and bone metastases. METHODS: We developed a surgical protocol for both spinal and appendicular metastases...
October 2016: Lancet
https://www.readbyqxmd.com/read/27936890/incidental-findings-in-the-skeletal-musculature-on-computed-tomography
#19
Dominik Schramm, Annkathrin Justus, Andreas Gunter Bach, Alexey Surov
OBJECTIVE: The purpose of this study was to analyze intramuscular incidental findings identified on computed tomography (CT) in a large patients cohort. METHODS: In the time period from 2010 to 2015 a total of 44 794 patients with several diagnoses were investigated by CT. Only patients, who underwent body CT including the neck, thorax, abdomen and pelvic regions after intravenous application of contrast medium were involved in the study. There were 4085 patients...
December 12, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27933280/bone-imaging-in-prostate-cancer-the-evolving-roles-of-nuclear-medicine-and-radiology
#20
REVIEW
Gary J R Cook, Gurdip Azad, Anwar R Padhani
The bone scan continues to be recommended for both the staging and therapy response assessment of skeletal metastases from prostate cancer. However, it is widely recognised that bone scans have limited sensitivity for disease detection and is both insensitive and non-specific for determining treatment response, at an early enough time point to be clinically useful. We, therefore, review the evolving roles of nuclear medicine and radiology for this application. We have reviewed the published literature reporting recent developments in imaging bone metastases in prostate cancer, and provide a balanced synopsis of the state of the art...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
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