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Skeletal metastases

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https://www.readbyqxmd.com/read/29672789/-skeletal-muscle-metastases
#1
Gordian Hamerla, Peter Voigt, Hans-Jonas Meyer, Alexey Surov
No abstract text is available yet for this article.
May 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29670999/mechanisms-involved-in-normal-and-pathological-osteoclastogenesis
#2
REVIEW
Kyung-Hyun Park-Min
Osteoclasts are bone-resorbing cells that play an essential role in bone remodeling. Defects in osteoclasts result in unbalanced bone remodeling and are linked to many bone diseases including osteoporosis, rheumatoid arthritis, primary bone cancer, and skeletal metastases. Receptor activator of NF-kappaB ligand (RANKL) is a classical inducer of osteoclast formation. In the presence of macrophage-colony-stimulating factor, RANKL and co-stimulatory signals synergistically regulate osteoclastogenesis. However, recent discoveries of alternative pathways for RANKL-independent osteoclastogenesis have led to a reassessment of the traditional mechanisms that regulate osteoclast formation...
April 18, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29665140/review-functional-and-hybrid-imaging-of-bone-metastases
#3
Gary J R Cook, Vicky Goh
Bone metastases are common, cause significant morbidity and impact on healthcare resources. While radiographs, computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy have frequently been used for staging the skeleton, it is recognized that these methods are insensitive and non-specific for monitoring treatment response in a clinically relevant time frame. We summarize several recent reports on new functional and hybrid imaging methods including single photon emission CT / CT, positron emission tomography / CT and whole-body MRI with diffusion-weighted imaging...
April 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29643680/fluorodeoxyglucose-positron-emission-tomography-computed-tomography-evaluation-of-an-interesting-case-of-uterine-carcinosarcoma-with-isolated-appendicular-skeletal-metastases
#4
Chidambaram Natrajan Balasubramanian Harisankar
Uterine carcinosarcomas, also known as malignant mixed mullerian tumors, are one of the rare and most aggressive neoplasms of the uterus. They have an aggressive course and can spread to distant organs. Owing to the low incidence of these tumors, the optimal adjuvant management after surgery is not well established. Many patients develop distant metastases during follow-up. An interesting case of uterine carcinosarcoma who developed metastases to the femur, tibia, and calcaneum during follow is presented.
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29643678/metabolic-bone-superscan-in-carcinoma-breast-with-occult-graves-disease-looking-beyond-skeletal-metastases
#5
Ashwin Singh Parihar, Ashwani Sood, Tinu Thadiyananickal Lukose, Rajeev Kumar Seam, Bhagwant Rai Mittal
Extrathyroidal manifestations of autoimmune thyroid disorders include thyroid-associated ophthalmopathy, thyroid dermopathy, and thyroid acropachy. Thyroid acropachy is an extreme manifestation of autoimmune thyroid disorder characterized by clubbing and swelling of fingers and toes, with or without periosteal reaction of the distal bones. We present a 50-year-old woman, posttreatment for carcinoma breast (6 years back) and referred for bone scan for generalized body ache. Bone scan findings resulting in detailed clinical evaluation prompted toward the suspicion of a thyroidal disease with ultimate diagnosis of Graves' disease...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29603079/effects-of-breast-and-prostate-cancer-metastases-on-lumbar-spine-biomechanics-rapid-in-silico-evaluation
#6
J Lorkowski, O Grzegorowska, M S Kozień, I Kotela
Metastases to distant organs are a frequent occurrence in cancer diseases. The skeletal system, especially the spine, is one such organ. The objective of this study was to apply a numerical modeling, using a finite element method (FEM), for the evaluation of deformation and stress in lumbar spine in bone metastases to the spine. We investigated 20 patients (10 women and 10 men) aged 38-81 years. In women, osteolytic lesions in lumbar spine accompanied breast cancer, in men it was prostate cancer. Geometry of FEM models were built based on CT scans of metastatic lumbar spine...
March 31, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29599310/antitumor-activity-of-novel-bone-seeking-%C3%AE-emitting-224-ra-solution-in-a-breast-cancer-skeletal-metastases-model
#7
Asta Juzeniene, Jenni Bernoulli, Mari Suominen, Jussi Halleen, Roy Hartvig Larsen
BACKGROUND/AIM: Bone metastases are associated with increased morbidity and poor prognosis in a variety of cancers. The present study investigated the effects of targeted radionuclide therapy with α-emitting, bone-seeking radium-224 (224 Ra) on osteolytic bone metastasis of MDA-MB-231(SA)-GFP human breast cancer cells injected intracardially into nude mice. MATERIALS AND METHODS: Vehicle, ethylenediamine tetra (methylene phosphonic acid) (EDTMP) and224 Ra-solution (45, 91 or 179 kBq/kg) with EDTMP were intravenously administered to mice two days after cell injection...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29577024/healthcare-resource-utilization-associated-with-radiation-to-bone-across-eight-european-countries-results-from-a-retrospective-study
#8
Roger von Moos, Jean-Jacques Body, Oliver Guenther, Evangelos Terpos, Yves Pascal Acklin, Jindrich Finek, João Pereira, Nikos Maniadakis, Guy Hechmati, Susan Talbot, Harm Sleeboom
Background: Bone metastases and lytic lesions due to multiple myeloma are common in advanced cancer and can lead to debilitating complications (skeletal-related events [SREs]), including requirement for radiation to bone. Despite the high frequency of radiation to bone in patients with metastatic bone disease, our knowledge of associated healthcare resource utilization (HRU) is limited. Methods: This retrospective study estimated HRU following radiation to bone in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland...
March 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29574162/surgical-treatment-in-bone-metastases-in-the-appendicular-skeleton
#9
M A Clara-Altamirano, D Y Garcia-Ortega, H Martinez-Said, C H S Caro-Sánchez, A Herrera-Gomez, M Cuellar-Hubbe
INTRODUCTION: Metastatic bone disease is the most common neoplastic process that affects the skeletal system. Eighty percent of bone metastases come from carcinomas of the breast, lung, kidney, thyroid and prostate. The Katagiri scale enables an estimation of the survival of patients based on the presence or absence of visceral metastases, multiple bone metastases and functional status according to the ECOG scale. MATERIAL AND METHODS: A retrospective, descriptive and observational study conducted between March 1, 2013 and June 30, 2015...
March 21, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29563739/overt-skeletal-metastases-in-a-patient-of-occult-microscopic-follicular-thyroid-carcinoma-a-rare-case
#10
Chandan Kumar Jha, Vinita Agrawal, Anjali Mishra, P K Pradhan
Occult follicular thyroid carcinoma (FTC) presenting as distant metastases is a rare occurrence. However, despite being occult in majority of these cases, primary tumor can be detected on thyroid imaging or during surgery. Here, we present an extremely rare case of an occult FTC with overt skeletal metastases in which primary tumor was discernible only on microscopic examination.
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29563734/skeletal-metastasis-an-epidemiological-study
#11
Balaji Zacharia, Dhiyaneswaran Subramaniam, Jerin Joy
Metastasis is the commonest bone tumors. The commonest primary metastasis to the bone are the breast, lung, prostate, kidney, and thyroid. The bone is the third common site of metastatic disease, only the lung and the liver have higher metastatic rate than skeleton. We have no epidemiological studies conducted to evaluate the various aspects of skeletal metastasis like age, sex distribution, presentation, common sites of primary and associated secondary metastases, and investigation from Indian subcontinent...
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29561523/99mtc-mdp-spect-ct-based-modified-mirels-classification-for-evaluation-of-risk-of-fracture-in-skeletal-metastasis-a-pilot-study
#12
Saima Riaz, Humayun Bashir, Imran Khalid Niazi, Sumera Butt, Faisal Qamar
Mirels' scoring system quantifies the risk of sustaining a pathologic fracture in osseous metastases of weight bearing long bones. Conventional Mirels' scoring is based on radiographs. Our pilot study proposes Tc MDP bone SPECT-CT based modified Mirels' scoring system and its comparison with conventional Mirels' scoring. Cortical lysis was noted in 8(24%) by SPECT-CT versus 2 (6.3%) on X-rays. Additional SPECT-CT parameters were; circumferential involvement [1/4 (31%), 1/2 (3%), 3/4 (37.5%), 4/4 (28%)] and extra-osseous soft tissue [3%]...
March 20, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29560759/chromophobe-renal-cell-carcinoma-with-retrograde-venous-invasion-and-gain-of-chromosome-21-potential-harbingers-of-aggressive-clinical-behavior
#13
Mohsin Jamal, Kanika Taneja, Sohrab Arora, Ravi Barod, Craig G Rogers, Jessica Sanchez, Nilesh S Gupta, Sean R Williamson
Occasionally, renal cell carcinoma (RCC) with renal vein extension spreads against the flow of blood within vein branches into the kidney, forming multifocal nodules throughout the renal parenchyma. These foci are not regarded as multiple tumors but rather reverse spread of tumor along the venous system. This intravascular spread has previously been reported in clear cell RCC and RCC unclassified. However, to our knowledge, this has never been reported in chromophobe RCC. Chromophobe RCC is a unique histologic subtype of renal cancer, generally thought to have less aggressive behavior...
March 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29553053/bone-targeted-therapies-to-reduce-skeletal-morbidity-in-prostate-cancer
#14
Tanya B Dorff, Neeraj Agarwal
Bone metastases are the main driver of morbidity and mortality in advanced prostate cancer. Targeting the bone microenvironment, a key player in the pathogenesis of bone metastasis, has become one of the mainstays of therapy in men with advanced prostate cancer. This review will evaluate the data supporting the use of bone-targeted therapy, including (1) bisphosphonates such as zoledronic acid, which directly target osteoclasts, (2) denosumab, a receptor activator of nuclear factor-kappa B (RANK) ligand inhibitor, which targets a key component of bone stromal interaction, and (3) radium-223, an alpha-emitting calcium mimetic, which hones to the metabolically active areas of osteoblastic metastasis and induces double-strand breaks in the DNA...
March 16, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29534588/change-in-fgf-2-circulating-levels-after-arterial-embolization-in-patients-with-bone-metastases
#15
G Rossi, M Salerno, D Granchi, E Cenni, G Facchini, N Baldini
Arterial embolization, aimed at the mechanical occlusion of tumor-feeding vessels, represents a satisfactory palliative therapy for bone metastases. In this study, we evaluated if the circulating levels of three factors related to the metastatic process change in response to embolization. Seven patients who underwent embolization of a single skeletal metastasis from carcinomas were analyzed prospectively. Circulating levels of Vascular Endothelial Growth Factor A (VEGF-A), Fibroblast Growth Factor 2 (FGF-2), and Tartrate-Resistant Acid Phosphatase-5b Isoform (TRACP5b) were evaluated before and after embolization at 1, 3, and 6 months...
2018: Neoplasma
https://www.readbyqxmd.com/read/29511626/incidence-risk-factors-and-prognostic-characteristics-of-bone-metastases-and-skeletal-related-events-sres-in-breast-cancer-patients-a-systematic-review-of-the-real-world-data
#16
REVIEW
Hongwei Zhang, Wei Zhu, Ewelina Biskup, Weige Yang, Ziang Yang, Hong Wang, Xiaochun Qiu, Chengjiao Zhang, Guangxia Hu, Guangfu Hu
Purpose: The aim was to systematically extrapolate the occurrence, risk factors, prognostic characteristics, management and outcome of bone metastases (BM) and skeletal related events (SREs) of breast cancer survivors in the real world clinical setting. Methods: A systematic literature search of PubMed, Web of Science, EMBASE OvidSP and EBSCO Academic Search Complete was conducted. Published prospective and retrospective papers investigating BM and SREs in breast cancer patients in non-trial settings were identified and systematically reviewed...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29511536/skeletal-metastasis-in-renal-cell-carcinoma-a-review
#17
REVIEW
Masood Umer, Yasir Mohib, Muhammed Atif, Muhammad Nazim
Background: Renal cell carcinoma account for 3% of all cancers, with peak incidence between 60 and 70 years of age predominantly affecting male population. Renal carcinoma is the most common malignancy of kidney constitutes for 80-90% of renal neoplasm with an overall 45% five years survival rate. Majority are diagnosed incidentally during investigation for other disease process of abdomen. Classical triad of gross hematuria, pain and palpable mass in abdomen is rare accounting to only 6-10%...
March 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29498482/rare-imaging-appearance-of-skeletal-metastases-in-a-61-year-old-breast-cancer-patient
#18
Eoin O'Shea, Seamus O'Reilly, Pauline Smiddy
No abstract text is available yet for this article.
March 2, 2018: Breast Journal
https://www.readbyqxmd.com/read/29481473/fortuitous-administration-of-denosumab-in-breast-carcinoma-with-osteoclastic-giant-cells
#19
Ilit Turgeman, Ezequiel Flechter, Eugene Vlodavsky, Daniela Militianu, Zohar Keidar, Elias Haddad, Gil Bar-Sela
Breast carcinoma with osteoclastic giant cells (OGCs) is a rare entity characterized by an admixture of giant cells and malignant epithelial cells within an inflammatory and vascular stroma. Denosumab is a monoclonal antibody that targets the pathway for osteoclast formation and activation, indicated for the prevention of skeletal-related events in patients with bone metastases, as well as for the treatment of giant cell tumor of bone. We report a patient who presented with aggressive bone recurrence of breast cancer 12 years after her original diagnosis, showing a transformed histology that included multinucleated OGCs, and that was refractory to traditional therapy...
February 23, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29474996/considerations-for-exercise-prescription-in-patients-with-bone-metastases-a-comprehensive-narrative-review
#20
REVIEW
Gráinne Sheill, Emer M Guinan, Nicola Peat, Juliette Hussey
Metastatic disease is a frequent complication of advanced cancer, with bone representing one of the most common sites of metastatic occurrence. Patients with bone metastases receive long-term systemic treatments that have a significant attritional impact on muscle strength, fatigue, and physical functioning. Physical rehabilitation involving exercise and physical activity prescription has a considerable role in counteracting these changes; however, exercise is often perceived as a contraindication in the presence of bone metastases due to concerns about aggravating skeletal related events...
February 21, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
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