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https://www.readbyqxmd.com/read/29036016/exercise-preserves-physical-function-in-prostate-cancer-patients-with-bone-metastases
#1
Daniel A Galvão, Dennis R Taaffe, Nigel Spry, Prue Cormie, David Joseph, Suzanne K Chambers, Raphael Chee, Carolyn Peddle-McIntyre, Nicolas H Hart, Freerk T Baumann, James Denham, Michael Baker, Robert U Newton
PURPOSE: The presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting due to concerns of fragility fracture. We examined the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases. METHODS: Between 2012 and 2015, 57 prostate cancer patients (70.0±8.4 years; BMI 28.7±4.0 kg/m) with bone metastases (pelvis 75...
October 14, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29033686/serendipitous-detection-of-extraosseous-metastases-on-bone-scintigraphy-utility-of-cross-sectional-and-correlative-imaging
#2
Jiwan Paudel, Harmandeep Singh, Ashwani Sood, Anish Bhattacharya, Bhagwant Rai Mittal
Whole body bone scintigraphy is most commonly used imaging modality to detect and assess the extent of osteoblastic osseous metastases in malignant conditions, though visceral metastases need additional imaging. The authors describe a case of 50-year-old postoperative breast cancer female where bone scintigraphy showed soft tissue uptake in thorax and hepatic region in addition to multiple skeletal metastases, indicating the involvement of three different organs by metastatic disease. The present case highlights that extraosseous tracer uptake in addition to abnormal osseous tracer uptake may raise the suspicion of widespread and visceral metastatic disease and warrant further evaluation in the form of cross-sectional and correlative imaging...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29033679/incremental-value-of-single-photon-emission-computed-tomography-computed-tomography-for-characterization-of-skeletal-lesions-in-breast-cancer-patients
#3
Thanuja Mahaletchumy, Aini AbAziz
The incremental value of single-photon emission computed tomography-computed tomography (SPECT-CT) over planar bone scintigraphy and SPECT in detecting skeletal lesions in breast cancer patients and its effect on patient management is assessed in this study. This is a prospective study which was conducted over 1-year duration. Whole-body planar scintigraphy, SPECT, and SPECT-CT were performed in 85 breast cancer patients with total of 128 lesions. Correlative imaging and clinical follow-up was used as the reference standard...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29033673/automated-bone-scan-index-as-predictors-of-survival-in-prostate-cancer
#4
Joko Wiyanto, Rini Shintawati, Budi Darmawan, Basuki Hidayat, Achmad Hussein Sundawa Kartamihardja
Prostate cancer (PCa) is the second most diagnosed cancer in men. Early diagnosis and right management of PCa is critical to reducing deaths; the life expectancy is the main factors to be considered in the management of PCa. Among patients who die from PCa, the incidence of skeletal involvement appears to be >85%. Bone scan (BS) is the most common method for monitoring bone metastases in patients with PCa. The extent of bone metastasis was also associated with patient survival until now there is no clinically useful technique for measuring bone tumors and includes this information in the risk assessment...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29023215/cost-effectiveness-analysis-of-monthly-zoledronic-acid-zoledronic-acid-every-3-months-and-monthly-denosumab-in-women-with-breast-cancer-and-skeletal-metastases-calgb-70604-alliance
#5
Charles L Shapiro, James P Moriarty, Stacie Dusetzina, Andrew L Himelstein, Jared C Foster, Stephen S Grubbs, Paul J Novotny, Bijan J Borah
Purpose Skeletal-related events (SREs) such as pathologic fracture, spinal cord compression, or the necessity for radiation or surgery to bone metastasis cause considerable morbidity, decrements in quality of life, and costs to the health care system. The results of a recent large randomized trial (Cancer and Leukemia Group B/Alliance for Clinical Trials in Oncology [CALGB/Alliance 70604]) showed that zoledronic acid (ZA) every 3 months was noninferior to monthly ZA in reducing the risks of SREs. We sought to determine the cost-effectiveness (CE) of monthly ZA, ZA every 3 months, and monthly denosumab in women with breast cancer and skeletal metastases...
October 12, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29022046/-radium-223-dichloride-in-patients-with-castration-refractory-prostate-cancer
#6
REVIEW
B M Winter, F-C von Rundstedt, M-O Grimm
Since November 2013, the alpha emitter radium-223 dichloride (Alpharadin/Xofigo®) has been approved for the treatment of men with castration-resistant prostate cancer (CRPC) with symptomatic bone metastases and no known visceral metastatic disease. In the ASYMPCA clinical trial, radium-223 was shown to improve overall survival and to reduce the time to the first symptomatic skeletal event. The use of radium-223 was associated with a reduction of pain and an improvement of health-related quality of life compared to the placebo arm...
October 11, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28978165/comparative-efficacy-and-safety-of-bone-modifying-agents-for-the-treatment-of-bone-metastases-in-patients-with-advanced-renal-cell-carcinoma-a-systematic-review-and-meta-analysis
#7
Kenji Omae, Yasushi Tsujimoto, Michitaka Honda, Tsunenori Kondo, Kazunari Tanabe, Shunichi Fukuhara, Toshi A Furukawa
OBJECTIVE: To determine the comparative efficacy and safety of all available bone-modifying agents (BMAs) for the treatment of bone metastases in patients with advanced renal cell carcinoma (RCC). RESULTS: Three studies (259 patients) were identified for the systematic review. Two studies that compared zoledronic acid with placebo or no zoledronic acid showed that zoledronic acid reduced the risk of skeletal-related events (SREs) by 68% (pooled hazard ratio [HR]: 0...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28961839/re-treatment-with-radium-223-first-experience-from-an-international-open-label-phase-i-ii-study-in-patients-with-castration-resistant-prostate-cancer-and-bone-metastases
#8
O Sartor, D Heinrich, N Mariados, M J Méndez Vidal, D Keizman, C Thellenberg Karlsson, A Peer, G Procopio, S J Frank, K Pulkkanen, E Rosenbaum, S Severi, J M Trigo Perez, V Wagner, R Li, L T Nordquist
Background: Six radium-223 injections at 4-week intervals is indicated for patients with castration-resistant prostate cancer and symptomatic bone metastases. However, patients usually develop disease progression after initial treatment. This prospective phase I/II study assessed re-treatment safety and efficacy of up to six additional radium-223 injections. Patients and methods: Patients had castration-resistant prostate cancer and bone metastases and six initial radium-223 injections with no on-treatment bone progression; all had subsequent radiologic or clinical progression...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28953207/a-proof-of-concept-study-analyzing-the-clinical-utility-of-fluorine-18-sodium-fluoride-pet-ct-in-skeletal-staging-of-oncology-patients-with-end-stage-renal-disease-on-dialysis
#9
Sharjeel Usmani, Fahad Marafi, Abdulredha Esmail, Najeeb Ahmed
PURPOSE: The quality of conventional bone scintigraphy can be poor in patients with end-stage renal disease (ESRD). Fluorine-18-sodium fluoride (F-NaF) PET-computed tomography (CT) has rapid single-pass extraction, fast clearance from the soft tissues and a better target to background ratio. The aim of the present study is to preliminarily assess the superior tracer kinetics of F-NaF in ESRD patients. MATERIALS AND METHODS: A cohort comprising of 13 patients with ESRD (mean age 65...
September 25, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28948139/the-role-of-biomarkers-in-the-management-of-bone-homing-malignancies
#10
REVIEW
Stella D'Oronzo, Janet Brown, Robert Coleman
Bone represents a common site of metastasis from several solid tumours, including breast, prostate and lung malignancies. The onset of bone metastases (BM) is associated not only with serious skeletal complications, but also shortened overall survival, owing to the lack of curative treatment options for late-stage cancer. Despite the diagnostic advances, BM detection often occurs in the symptomatic stage, underlining the need for novel strategies aimed at the early identification of high-risk patients. To this purpose, both bone turnover and tumour-derived markers are being investigated for their potential diagnostic, prognostic and predictive roles...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28947878/diagnostic-methods-for-detection-of-bone-metastases
#11
REVIEW
Bartosz Łukaszewski, Jerzy Nazar, Maciej Goch, Marta Łukaszewska, Adrian Stępiński, Mieczysława U Jurczyk
Skeletal metastases are severe complications in the course of cancer, and they indicate a worse prognosis. The use of modern imaging techniques allows rapid diagnosis of bone metastases. Properly selected diagnostic imaging (scintigraphy, positron emission tomography, whole body MRI) allows us to evaluate the number of metastatic foci in the skeletal system. Complementary imaging examinations (X-ray, computed tomography, magnetic resonance imaging) determine the extent of metastasis and its character: osteolytic, osteoblast, mixed)...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28941210/osteonecrosis-of-the-jaw-and-survival-of-patients-with-cancer-a-nationwide-cohort-study-in-denmark
#12
Priscila Corraini, Uffe Heide-Jørgensen, Morten Schiødt, Sven Erik Nørholt, John Acquavella, Henrik Toft Sørensen, Vera Ehrenstein
Osteonecrosis of the jaw (ONJ) is an adverse effect of bone-targeted therapies, which are used to prevent symptomatic skeletal events following bone malignancy. We examined the association between ONJ and survival among cancer patients treated with bone-targeted agents. Using nationwide registries and databases in Denmark, we identified 184 cancer patients with incident ONJ between 2010 and 2015, and a comparison cohort of 1067 cancer patients without ONJ and with a history of hospital-administered treatment with bisphosphonates or denosumab initiating from cancer diagnosis...
September 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28936708/impact-of-visceral-adiposity-as-well-as-sarcopenic-factors-on-outcomes-in-patients-undergoing-liver-resection-for-colorectal-liver-metastases
#13
Atsushi Kobayashi, Toshimi Kaido, Yuhei Hamaguchi, Shinya Okumura, Hisaya Shirai, Naoko Kamo, Shintaro Yagi, Kojiro Taura, Hideaki Okajima, Shinji Uemoto
OBJECTIVES: We have reported preoperative low skeletal muscularity as an independent risk factor for poor outcomes after liver transplantation, resection of hepatocellular carcinoma, pancreatic cancer and extrahepatic biliary malignancies. However, the impacts of visceral adiposity and muscularity on outcomes after liver resection for colorectal liver metastases (CLM) have not been fully investigated. METHODS: We retrospectively analyzed 124 patients undergoing primary liver resection for CLM between 2005 and 2014...
September 21, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28934820/-bone-metastases-pathophysiology-diagnostic-testing-and-therapy-part-1
#14
Sebastian Koob, Michael Kehrer, Andreas Strauss, Viktor Janzen, Dieter Christian Wirtz, Jan Schmolders
In Germany and other European countries, cancer is the second most common cause of death after cardiovascular disease. Although 5-year survival rates for several types of cancer have significantly improved over the last 30 years, metastasis to the bone almost always leads to incurable disease. Aside from the rare primary bone tumours, the treatment of bone metastases now accounts for a major part of tumour orthopaedic workload and requires close interdisciplinary coordination between specialists in oncology, radiology and the discipline of the primary tumour entity...
September 21, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28923958/multiscale-characterization-of-the-mineral-phase-at-skeletal-sites-of-breast-cancer-metastasis
#15
Frank He, Aaron E Chiou, Hyun Chae Loh, Maureen Lynch, Bo Ri Seo, Young Hye Song, Min Joon Lee, Rebecca Hoerth, Emely L Bortel, Bettina M Willie, Georg N Duda, Lara A Estroff, Admir Masic, Wolfgang Wagermaier, Peter Fratzl, Claudia Fischbach
Skeletal metastases, the leading cause of death in advanced breast cancer patients, depend on tumor cell interactions with the mineralized bone extracellular matrix. Bone mineral is largely composed of hydroxyapatite (HA) nanocrystals with physicochemical properties that vary significantly by anatomical location, age, and pathology. However, it remains unclear whether bone regions typically targeted by metastatic breast cancer feature distinct HA materials properties. Here we combined high-resolution X-ray scattering analysis with large-area Raman imaging, backscattered electron microscopy, histopathology, and microcomputed tomography to characterize HA in mouse models of advanced breast cancer in relevant skeletal locations...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28916624/bone-marrow-and-not-bone-metastases-is-what-21st-century-diagnostic-imaging-must-focus-upon-when-looking-for-skeletal-metastases
#16
Poul Flemming Høilund-Carlsen, Søren Hess, Abass Alavi
No abstract text is available yet for this article.
September 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28904733/-bone-metastases-from-malignant-melanoma-detected-on-18f-fdg-pet-in-a-patient-with-normal-skeletal-scintigraphy
#17
Abderrahim Doudouh, Abdelhamid Biyi
No abstract text is available yet for this article.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28901496/high-ccl5-expression-is-associated-with-osteosarcoma-metastasis-and-poor-prognosis-of-patients-with-osteosarcoma
#18
Kai Sun, Chen Gong, Hao Peng, Hongsong Fang, Jianlin Zhou, Jianping Li, Sen Chen, Huifeng Zheng
Osteosarcoma is the most common primary malignant tumor of the skeletal system and is characterized by an aggressive clinical course and high metastatic potential. Regulated upon Activation Normal T cell Expressed and Secreted, also termed C‑C motif chemokine ligand 5 (CCL5), is associated with metastasis and poor prognosis in various types of cancer. The aim of the current study was to investigate the association between CCL5 expression and clinicopathological features and prognosis in patients with osteosarcoma...
September 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28895205/baseline-low-serum-dehydroepiandrosterone-sulfate-can-predict-poor-responsiveness-to-hormone-therapy-in-patients-with-hormone-na%C3%A3-ve-prostate-cancer-with-skeletal-metastases
#19
Akihiro Yano, Makoto Kagawa, Hideki Takeshita, Yohei Okada, Makoto Morozumi, Satoru Kawakami
No abstract text is available yet for this article.
September 11, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28887581/multiple-skeletal-muscle-metastases-revealing-a-cardiac-intimal-sarcoma
#20
Amandine Crombé, Pierre-François Lintingre, François Le Loarer, Denis Lachatre, Benjamin Dallaudière
We report the case of a 59-year-old female with progressive bilateral painful swelling of the thighs. MRI revealed multiple intramuscular necrotic masses with similar morphologic patterns. Whole-body CT and 18-FDG PET-CT scans demonstrated additional hypermetabolic muscular masses and a lobulated lesion within the left atrial cavity. As biopsy of a muscular mass was compatible with a poorly differentiated sarcoma with MDM2 oncogene amplification, two diagnoses were discussed: a dedifferentiated liposarcoma with muscle and heart metastases or a primary cardiac sarcoma, mainly a cardiac intimal sarcoma, with muscular metastases, which was finally confirmed by array-comparative genomic hybridization (aCGH) in a sarcoma reference center...
September 8, 2017: Skeletal Radiology
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