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Li Zhengguang, Huang Jie, Zhang Yong, Cao Jiaojiao, Wang Xingqi, Chu Xiaoqin
OBJECTIVE: The purpose of this study is to research the mechanism of percutaneous penetration of Ibuprofen (IBU) nanoemulsion. METHOD: Transdermal penetration mechanism of IBU n anoemulsion was investigated by Fourier Transform infra-Red spectral analysis (FTIR), Differential Scanning Calorimeter thermogram (DSC), activation energy(Ea) measurement The in vivo skin penetration test of rats was carried out using Rhodamine B nanoemulsion to simulate the process of drug penetration into the skin, and the frozen section of the skin was observed by Confocal laser scanning microscopy (CLSM)...
November 16, 2018: Drug Development and Industrial Pharmacy
Aydin Sadeqi, Hojatollah Rezaei Nejad, Gita Kiaee, Sameer Sonkusale
In this paper we present fabrication of hollow and solid chitosan microneedles using a recently proposed low-cost and cleanroom-free fabrication method called Cross-Over Lines (COL) laser engraving. COL engraving is achieved using a commercial CO2 laser-cutter to create microneedle molds on acrylic sheet. PDMS is then casted on the acrylic sheet microneedle mold to create base PDMS microneedles which are then used to generate other polymeric needles. In this paper, we cast and cure chitosan solution on the base PDMS microneedles which easily detaches from PDMS needles on drying...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Renato Grillo, Fabiana V Dias, Samyr M Querobino, Carlos Alberto-Silva, Leonardo F Fraceto, Eneida de Paula, Daniele R de Araujo
In recent years, the development of hybrid drug delivery systems, such as hydrogels and nanoparticles, has gained considerable attention as new formulations for skin-delivery. Meanwhile, transdermal diffusion synthetic membranes have been used to assess skin permeability to these systems, providing key insights into the relationships between drug and nanoformulations. In this study, benzocaine-loaded poly-ε-caprolactone nanoparticles (BZC:NPs) were synthesized, characterized and incorporated into Poloxamer 407-based hydrogel (PL407)...
October 26, 2018: Colloids and Surfaces. B, Biointerfaces
Pierre A Hanna, Mamdouh M Ghorab, Shadeed G Shadeed
Betamethasone dipropionate is a highly effective corticosteroid anti-inflammatory. However, the main drawback of its topical use is the limited skin penetration into deeper skin layers. Also, its systemic use has shown many side effects. The goal of this research was to formulate betamethasone dipropionate in nanostructured lipid carriers (NLC) formulae that contain oleic acid to aid its penetration to deeper skin layers and to aid absorption to local regions upon topical application.NLC formulae were prepared by high shear homogenization then sonication...
November 14, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
Daniel P Krull, Stephanie Ann Thomovsky, Annie Vivian Chen, Katrina L Mealey, Mark G Papich
The purpose was to determine the safety and achievable serum concentrations of transdermally administered phenobarbital in healthy cats. The hypothesis was that transdermal phenobarbital would achieve therapeutic serum concentrations (15-45 µg/mL) with minimal short-term adverse effects. Enrolled cats had normal physical and neurologic exams and unremarkable bloodwork. Transdermal phenobarbital in a pluronic lecithin organogel-based vehicle was administered at a dosage of 3.0-3.1 mg/kg per ear pinna (total of 6...
November 14, 2018: Journal of the American Animal Hospital Association
Andrew Stier, Eshan Halekote, Andrew Mark, Shutao Qiao, Shixuan Yang, Kenneth Diller, Nanshu Lu
Wearable tissue heaters can play many important roles in the medical field. They may be used for heat therapy, perioperative warming and controlled transdermal drug delivery, among other applications. State-of-the-art heaters are too bulky, rigid, or difficult to control to be able to maintain long-term wearability and safety. Recently, there has been progress in the development of stretchable heaters that may be attached directly to the skin surface, but they often use expensive materials or processes and take significant time to fabricate...
April 8, 2018: Micromachines
Yongwei Gu, Xiaomeng Tang, Meng Yang, Dishun Yang, Jiyong Liu
The objective of this present study was to develop and evaluate the triptolide-loaded nanostructured lipid carriers (TPL-NLCs) for transdermal drug delivery system (TDDS). TPL-NLCs was prepared with emulsification technique and optimized by central composite design of a response surface methodology (CCD-RSM). The optimized TPL-NLCs were spherical and physically stable with the average size of 139.6.0 ± 2.53 nm and Zeta potential of -36.03 ± 2.41 mV. The encapsulation efficiency and drug loading were 97...
November 10, 2018: International Journal of Pharmaceutics
Laura E González García, Melanie N MacGregor, Rahul Madathiparambil Visalakshan, Neethu Ninan, Alex A Cavallaro, Abigail D Trinidad, Yunpeng Zhao, A John D Hayball, Krasimir Vasilev
Microneedle patches have become an exciting means for transdermal delivery of various therapeutics. Herein, we report on self-sterilizing dissolving nanosilver-loaded microneedle patches created from carboxymethylcellulose capable of suppressing microbial pathogen growth at the insertion site.
November 12, 2018: Chemical Communications: Chem Comm
Aaro V Salminen, Juliane Winkelmann
PURPOSE OF REVIEW: The purpose of this review article is to summarize and discuss the recent advances in the treatment of restless legs syndrome (RLS), as well as REM sleep behavior disorder (RBD), and periodic leg movement disorder (PLMD). RECENT FINDINGS: Traditionally, dopaminergic therapy has been considered the sole option for first-line treatment of RLS due to their impressive acute efficacy. Dopamine agonists such as oral pramipexole and ropinirole, as well as transdermal rotigotine are all effective treatment options...
November 9, 2018: Current Treatment Options in Neurology
Marin Golčić, Renata Dobrila-Dintinjana, Goran Golčić, Lidija Gović-Golčić
Introduction: Opioids are the most important drugs in treating pain in palliative care patients. Transdermal formulations are especially useful due to their noninvasive nature and minimal interference in daily life. However, studies have shown a controversial relationship of opioids to survival and a rise in deaths associated with the use of transdermal opioids. Although applying precise doses is paramount, we have no clear recommendations for the exact equianalgesic ratio for buprenorphine patch and no recommendation for the type of transdermal opioid to use in hospice...
2018: Pain Research and Treatment
Kakali Choudhury, Partha Dasgupta, Nishana Paul, Krishnangshu Bhajna Choudhury, Bodhisatta Roy, Shampa Maity
Background and Objective: The study was designed to compare the efficacy and adverse effects of buprenorphine transdermal (TD) against oral morphine in pain management of cancer patient. Methods: A randomized open-labeled prospective study was done in palliative cancer pain clinic in a tertiary care medical college between August 2017 and January 2018, to compare the efficacy (pain assessed by VAS) and adverse events (CTCAEv4) between arm A, buprenorphine TD, (20 μg/h, extended 7 days formulation) and arm B, oral morphine (10mg immediate releasing formulation)...
October 2018: Indian Journal of Palliative Care
Jonathan Hindmarsh, Sharlene Hindmarsh, Mark Lee, Richard Telford
BACKGROUND: This case report describes a patient with known idiopathic Parkinson's disease, being managed with transdermal rotigotine, whose refractory nausea and vomiting was successfully controlled with subcutaneous levomepromazine. No drug-induced extrapyramidal side effects emerged. CASE PRESENTATION: A patient was found to have a locally advanced serous carcinoma, causing secondary bowel obstruction. Furthermore, due to compromised oral access, the patient's oral antiparkinsonian medications for motor control were converted to transdermal rotigotine...
November 8, 2018: Palliative Medicine
Chihiro Naito, Hidemasa Katsumi, Tomoko Suzuki, Ying-Shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto
Human parathyroid hormone (1-34) (PTH) has been widely used as the subcutaneous injection formulation for the treatment of osteoporosis. In the present study, we developed an efficient transdermal delivery system of PTH by using dissolving microneedle arrays (MNs) composed of hyaluronic acid (HA) for the treatment of osteoporosis. PTH-loaded MNs, with needle length 800 µm, were fabricated via a micro-molding method. The stability of PTH in MNs was found to be 6-fold higher than that of PTH solution when stored at room temperature (15⁻20 °C) for one month...
November 4, 2018: Pharmaceutics
Natasa Gisev, Sallie-Anne Pearson, Briony Larance, Sarah Larney, Bianca Blanch, Louisa Degenhardt
PURPOSE: Although guidelines caution against initiation of transdermal (TD) fentanyl among those who are opioid naïve, there is concern that not all people receive adequate prior opioid exposure. This study examined the percentage of people who are opioid naïve at the time of TD fentanyl initiation in Australia; strengths initiated; and characteristics associated with being opioid naïve. METHODS: This is a national retrospective cohort study derived from a 10% sample of Pharmaceutical Benefits Scheme concessional beneficiaries initiating TD fentanyl between 29 September 2009-31 December 2013...
November 3, 2018: European Journal of Clinical Pharmacology
Claire Desfrançois, Rachel Auzély, Isabelle Texier
Several drug delivery systems already exist for the encapsulation and subsequent release of lipophilic drugs that are well described in the scientific literature. Among these, lipid nanoparticles (LNP) have specifically come up for dermal, transdermal, mucosal, intramuscular and ocular drug administration routes in the last twenty years. However, for some of them (especially dermal, transdermal, mucosal), the LNP aqueous dispersions display unsuitable rheological properties. They therefore need to be processed as semi-solid formulations such as LNP-hydrogel composites to turn into versatile drug delivery systems able to provide precise spatial and temporal control of active ingredient release...
November 1, 2018: Pharmaceuticals
Pouya Azar, Mohammadali Nikoo, Isabelle Miles
BACKGROUND AND OBJECTIVES: Although buprenorphine/naloxone is widely recognized as first-line therapy for opioid use disorder, the requirement for moderate withdrawal prior to initiation in efforts to avoid precipitated withdrawal can be a barrier to its initiation. METHODS: We present a case utilizing transdermal fentanyl as a bridging treatment to eliminate withdrawal during the transition from methadone to buprenorphine/naloxone in a patient who had ongoing significant intravenous heroin use while on methadone...
November 2, 2018: American Journal on Addictions
Moumita Khamrai, Sovan Lal Banerjee, Saikat Paul, Sarthik Samanta, Patit Paban Kundu
In this context, we have prepared a biocompatible gelatin based polyelectrolyte hydrogel patch that has an inherent ability to self-heal in the presence of physiological pH (pH = 7.4). The gelatin-based hydrogel patch consists of the ionically modified self-assembled bacterial cellulose (iBC), extracted from Glucanoacetobacter xylinus (MTCC7795) bacterial strain. Presence of the iBC provides a sturdy cage to the gelatin matrix and also participates into the self-healing activity via formation of the ionic interlocking system in the presence of buffer solution having a pH of 7...
October 29, 2018: International Journal of Biological Macromolecules
Uyen Minh Le, Sarah Baltzley, Abeer AlGhananeem
In the outpatient pharmacy compounding, gabapentin, an anti-epileptic agent, has been commonly prescribed to be prepared alone or in combination with other agents in Pluronic lecithin organogel for transdermal pain management and palliative care. The objective of this study was to formulate and characterize gabapentin encapsulated elastic liposomes and then compare the gabapentin-based liposomes with compounded gabapentin-based Pluronic lecithin organogel regarding their efficiency in transdermal delivery of gabapentin...
November 2018: International Journal of Pharmaceutical Compounding
Shawn Needham, Shane Needham
Transdermal testosterone has been used for years to treat patients with low testosterone symptoms. Clinically, we have monitored patients to evaluate results of testosterone absorption via blood serum concentrations. The data on multiple time points to determine trough and peak concentrations is lacking in the literature. In this case study, we demonstrate the absorption of testosterone cream via scrotal delivery. The data suggests that after application therapeutic levels are reached with concentrations of (1204...
November 2018: International Journal of Pharmaceutical Compounding
Mudra Saurabh Kapoor, Anisha D'Souza, Noorjahan Aibani, Swathi Sivasankaran Nair, Puja Sandbhor, Durga Kumari, Rinti Banerjee
Oral folate fortification has been successful in many developed nations, however, developing countries still face low compliance and high incidence of folate deficiency associated with low birth weight infants and preterm deliveries. We report safe and efficient approach for transdermal systemic folate delivery using fluidising liposomes (120 ± 4 nm) stabilised within 3D matrix of naturally occurring cosmetic bases: Fuller's earth and henna with room temperature stability. The proof of stratum corneum fluidisation was established ex-vivo by Langmuir-Blodgett film, FTIR and confocal imaging in rat skin...
October 31, 2018: Scientific Reports
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