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https://www.readbyqxmd.com/read/29691454/heterologous-dna-prime-protein-boost-immunization-with-reca-and-flid-offers-cross-clade-protection-against-leptospiral-infection
#1
Veerapandian Raja, Sankaran Sobana, Charles Solomon Akino Mercy, Bianca Cotto, Durlav Prasad Bora, Kalimuthusamy Natarajaseenivasan
The emergence of >300 serovars of Leptospira confounded the use of generalized bacterin, the whole cell lysate, as vaccines to control leptospirosis. Because of substantial genetic and geographic heterogeneity among circulating serovars, one vaccine strain per serovar cannot be efficacious against all the serovars. We have performed heterologous DNA prime-protein boost vaccination challenge studies in hamsters using in vivo expressed, leptospiral recombinase A (RecA) and flagellar hook associated protein (FliD)...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691415/adjuvant-chemotherapy-after-surgery-can-improve-clinical-outcomes-for-patients-with-ib2-iib-cervical-cancer-with-neoadjuvant-chemotherapy-followed-by-radical-surgery
#2
Haiying Sun, Kecheng Huang, Fangxu Tang, Xiong Li, Xiaoli Wang, Sixiang Long, Shasha Zhou, Suolangquzhen, Jianwei Zhang, Ruoqi Ning, Shuang Li, Shixuan Wang, Ding Ma
The aim of the study is to evaluate the efficacy of postoperative treatments based on pathological response for cervical cancer patients who received neoadjuvant chemotherapy (NACT) followed by radical surgery. Firstly, a total of 756 cervical squamous cell cancer (SCC) patients with FIGO IB2-IIB were included in this retrospective study. Then data from a prospective cohort of 393 patients was employed for further validation. Overall survival (OS) and disease-free survival (DFS) were assessed. In the retrospective study, SCC patients who accepted adjuvant chemotherapy after radical surgery had a relatively better OS than those who received no therapy (P = 0...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691149/the-role-of-radiation-therapy-in-the-treatment-of-stage-ii-endometrial-cancer-a-large-database-study
#3
Andrzej P Wojcieszynski, Craig R Hullett, Erin E Medlin, Neil K Taunk, Jacob E Shabason, Jeffrey V Brower, Shuai Chen, Justin E Bekelman, Lisa M Barroilhet, Kristin A Bradley
PURPOSE: The optimum adjuvant treatment for Stage II endometrial cancer patients is unknown. External beam radiation therapy (EBRT) is often considered the standard of care; however, retrospective series suggest that brachytherapy (BT) alone may be sufficient for selected patients. As randomized data are lacking, we used a large database to explore this question. METHODS AND MATERIALS: The National Cancer Data Base was queried for patients with pathologic International Federation of Gynecology and Obstetrics Stage II disease...
April 21, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29691145/extended-endoscopic-endonasal-surgery-for-clival-chordoma-and-chondrosarcoma-our-experience-in-14-cases
#4
Diego Culebras, Jorge Torales, Luis Alberto Reyes, Luis Zapata, Sergio García, Pedro Roldán, Cristóbal Langdon, Issam Alobid, Joaquim Enseñat
OBJECTIVE: To report our experience in the management of chordoma and chondrosarcoma with extended endoscopic endonasal surgery. METHOD: We performed a retrospective analysis of a series of 14 patients with clival chordoma or chondrosarcoma who had extended endoscopic endonasal surgery from 2008 to 2016 performed by the same multidisciplinary team. RESULTS: We had fourteen patients (male/female 2:1), with a mean age of 49years for chordoma and 32 for chondrosarcoma...
April 21, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29691144/papillary-tumor-of-the-pineal-region-case-report-and-review-of-the-literature
#5
M A Cañizares Méndez, Manuel Amosa Delgado, Juan Antonio Álvarez Salgado, Jorge Javier Villaseñor Ledezma, Elena Capilla Cabezuelo, Francisco Díaz Crespo
Papillary tumor of the pineal region is a rare neuroepithelial tumor characterized by papillary architecture and epithelial cytology, immunopositivity for cytokeratin and ependymal differentiation. It is considered grade II-III by the World Health Organization and was first described by Jouvet in 2003. We present a 34-year-old male with headaches, blurred vision and normal examination. Radiological study showed a nodulocystic lesion in the pineal region compatible with pineocytoma. Surgery was performed using an infratentorial supracerebellar approach, finding a cystic tumor in the quadrigeminal cistern which was completely resected...
April 21, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29691095/role-of-hydroxyurea-as-an-adjuvant-treatment-after-gamma-knife-radiosurgery-for-atypical-who-grade-ii-meningiomas
#6
Khalid Abdel Karim, Amr El Shehaby, Reem Emad, Wael Reda, Manal El Mahdy, Ramy Ghali, Ahmed Nabeel
No abstract text is available yet for this article.
April 21, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29690894/uniportal-video-assisted-thoracoscopic-surgery-following-neoadjuvant-chemotherapy-for-locally-advanced-lung-cancer
#7
Zhiqiang Yang, Chunbo Zhai
BACKGROUND: Several retrospective studies have confirmed that video-assisted thoracoscopic surgery (VATS) following neoadjuvant chemotherapy is a safe and feasible treatment for advanced non-small cell lung cancer patients. As a minimally invasive technique, VATS usually leads to better clinical outcomes and better compliance with adjuvant treatment than conventional thoracotomy. Uniportal VATS (U-VATS) as an alternative option to conventional multi-port VATS has attracted much attention recently because reduced number and size of incisions may help to decrease inflammatory response and reduce postoperative pain for patients...
April 24, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29690864/radiogenic-angiosarcoma-of-the-breast-case-report-and-systematic-review-of-the-literature
#8
Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A Rezniczek, Clemens B Tempfer
BACKGROUND: Radiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized therapy for this type of malignancy. CASE PRESENTATION: We present the case of a 54 year old woman with RASB (poorly differentiated angiosarcoma of the left breast; pT1, pNX, M0, L0, V0) and a history of invasive-ductal cancer of the left breast (pT1b, G2, pN0, ER positive, PR positive, HER-2/neu negative) treated in July 2012 with breast-conserving surgery, adjuvant chemotherapy with 6 cycles of epirubicin and cyclophosphamide, adjuvant irradiation of the left breast with 50 Gray, and adjuvant endocrine therapy with an aromatase inhibitor...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29690724/-the-effect-of-berberine-on-ameliorating-chronic-inflammatory-pain-and-depression
#9
F Xu, J Yang, B Meng, J W Zheng, Q Liao, J P Chen, X W Chen
Objective: To explore the effect of berberine on chronic inflammatory pain and the comorbid depression and the associated mechanisms. Methods: Forty healthy male ICR mice (2 months, 25-30 g) were used in the present study. The chronic inflammatory pain was induced by intraplantar injection of complete freund's adjuvant (CFA) to the hind paws. All animals were divided into 4 groups ( n =10 for each group) according to random number table: the saline group (group A), the chronic pain group (group B), the saline+ berberine group (group C) and the chronic pain+ berberine group (group D)...
April 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29690504/selective-inhibition-of-histone-deacetylation-in-melanoma-increases-targeted-gene-delivery-by-a-bacteriophage-viral-vector
#10
Samuel Campbell, Keittisak Suwan, Sajee Waramit, Eric Ofori Aboagye, Amin Hajitou
The previously developed adeno-associated virus/phage (AAVP) vector, a hybrid between M13 bacteriophage (phage) viruses that infect bacteria only and human Adeno-Associated Virus (AAV), is a promising tool in targeted gene therapy against cancer. AAVP can be administered systemically and made tissue specific through the use of ligand-directed targeting. Cancer cells and tumor-associated blood vessels overexpress the αν integrin receptors, which are involved in tumor angiogenesis and tumor invasion...
April 21, 2018: Cancers
https://www.readbyqxmd.com/read/29689623/non-union-fractures-mesenchymal-stem-cells-and-bone-tissue-engineering
#11
REVIEW
Shirin Toosi, Nima Behravan, Javad Behravan
Depending on the duration of healing process, 5-10% of bone fractures may result in either non-union or delayed union. Because non-unions remain a clinically important problem, there is interest in the utilization of tissue engineering strategies to augment bone fracture repair. Three basic biologic elements that are required for bone regeneration include cells, extracellular matrix scaffolds and biological adjuvants for growth, differentiation and angiogenesis. Mesenchymal Stem Cells (MSCs) are capable to differentiate into various types of the cells including chondrocytes, myoblasts, osteoblasts, and adipocytes...
April 24, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29689622/prognostic-value-of-chromosomal-imbalances-gene-mutations-and-bap1-expression-in-uveal-melanoma
#12
Serena Patrone, Irena Maric, Mariangela Rutigliani, Francesco Lanza, Matteo Puntoni, Barbara Banelli, Silvia Rancati, Giovanna Angelini, Adriana Amaro, Paolo Ligorio, Carlotta Defferrari, Mauro Castagnetta, Roberto Bandelloni, Carlo Mosci, Andrea DeCensi, Massimo Romani, Urlich Pfeffer, Silvia Viaggi, Domenico A Coviello
Uveal melanoma (UM) exhibits recurring chromosomal abnormalities and gene driver mutations, which are related to tumor evolution/progression. Almost half of the patients with UM develop distant metastases, predominantly to the liver, and so far there are no effective adjuvant therapies. An accurate UM genetic profile could assess the individual patient's metastatic risk, and provide the basis to determine an individualized targeted therapeutic strategy for each UM patient. To investigate the presence of specific chromosomal and gene alterations, BAP1 protein expression, and their relationship with distant progression free survival (DPFS), we analyzed tumor samples from 63 UM patients (40 men and 23 women, with a median age of 64 years), who underwent eye enucleation by a single cancer ophthalmologist from December 2005 to June 2016...
April 24, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29689595/potentially-inappropriate-medication-use-in-older-patients-with-breast-and-colorectal-cancer
#13
Meghan S Karuturi, Holly M Holmes, Xiudong Lei, Michael Johnson, Carlos H Barcenas, Scott B Cantor, Gary E Gallick, Robert C Bast, Sharon H Giordano
BACKGROUND: The objective of this study was to determine patient characteristics associated with potentially inappropriate medication (PIM) use and its impact on outcomes for patients with breast or colorectal cancer receiving adjuvant chemotherapy. METHODS: The Surveillance, Epidemiology, and End Results database, linked to Medicare claims, was used. The cohort included patients who were 66 years old or older and were diagnosed with stage II or III breast or colorectal cancer between July 1, 2007, and December 31, 2009...
April 24, 2018: Cancer
https://www.readbyqxmd.com/read/29689399/primary-focal-intracranial-leptomeningeal-glioma-pfilg-a-case-report-and-review-of-literature
#14
Vinayak Narayan, Amey Savardekar, Nasser Mohammed, Devi Prasad Patra, Maria-Magdalena Georgescu, Anil Nanda
BACKGROUND: Primary focal intracranial leptomeningeal glioma [PFILG] is considered as a rare solitary glial tumor arising from the leptomeninges without brain attachment or evidence of primary neoplasm elsewhere within the neuraxis. We herein report a case of PFILG in left parietal location with a concise review on its clinico-radiological, histopathological and management characteristics. CASE PRESENTATION: A 75 year old lady presented with focal motor seizures involving right upper limb with associated occasional headache...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29688836/pediatric-salivary-cancer-epidemiology-treatment-trends-and-association-of-treatment-modality-with-survival
#15
Elliot Morse, Rance J T Fujiwara, Zain Husain, Benjamin Judson, Saral Mehra
Objective To characterize the epidemiology of pediatric salivary cancer and associate patient, tumor, and treatment factors with treatment modality and survival. Study Design Cross-sectional analysis. Setting US national database. Subjects and Methods We identified 588 patients 19 years or younger diagnosed with salivary cancer in the National Cancer Database 2004-2013. We characterized patient, tumor, and treatment factors as proportions and associated these factors with treatment modality and overall survival via multivariable logistic regression and multivariable Cox proportional hazards regression, respectively...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29688627/photobiomodulation-of-a-flowable-matrix-in-a-human-skin-ex-vivo-model-demonstrates-energy-based-enhancement-of-engraftment-integration-and-remodeling
#16
Lia Mara Grosso Neves, Nivaldo Antonio Parizotto, Marcia Regina Cominetti, Ardeshir Bayat
The use of dermal substitutes to treat skin defects such as ulcers has shown promising results, suggesting a potential role for skin substitutes for treating acute and chronic wounds. One of the main drawbacks with the use of dermal substitutes is the length of time from engraftment to graft take, plus the risk of contamination and failure due to this prolonged integration. Therefore, the use of adjuvant energy-based therapeutic modalities to augment and accelerate the rate of biointegration by dermal substitute engraftments is a desirable outcome...
April 24, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29688510/study-protocol-early-stereotactic-gamma-knife-radiosurgery-to-residual-tumor-after-surgery-of-newly-diagnosed-glioblastoma-gamma-gbm
#17
Stefanie Brehmer, Mario Alexander Grimm, Alex Förster, Marcel Seiz-Rosenhagen, Grit Welzel, Florian Stieler, Frederik Wenz, Christoph Groden, Sabine Mai, Daniel Hänggi, Frank Anton Giordano
BACKGROUND: Glioblastoma (GBM) is the most common malignant brain tumor in adult patients. Tumor recurrence commonly occurs around the resection cavity, especially after subtotal resection (STR). Consequently, the extent of resection correlates with overall survival (OS), suggesting that depletion of postoperative tumor remnants will improve outcome. OBJECTIVE: To assess safety and efficacy of adding stereotactic radiosurgery (SRS) to the standard treatment of GBM in patients with postoperative residual tumor...
April 24, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29688201/-detralex-phlebosclerosing-treatment-results-of-the-national-multicenter-follow-up-programme-vein-act-prolonged-c1
#18
V Iu Bogachev, B V Boldin, P Iu Turkin
Presented herein are the results of the observational follow up study programme dedicated to the assessment of appropriate use of adjuvant therapy with Detralex while carrying out phlebosclerosing treatment in patients suffering from dilated intradermal veins (clinical class C1 according to the CEAP classification). A conclusion was drawn that administration of Detralex for 60 days decreased the incidence rate of typical undesirable side events after phlebosclerosing therapy, thus making the use of this drug appropriate in routine clinical practice...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29688038/immunization-against-pr8-influenza-virus-with-chitosan-coated-iscomatrix-nanoparticles
#19
Jafar Mosafer, Ali Badiee, Zahra Mohammadamini, Alireza Komeilinezhad, Mohsen Tafaghodi
Chitosan-coated ISCOMATRIX nanoparticles co-administrated with PR8 influenza virus were successfully developed via a lipid film hydration method to evaluate their in vivo immuniadjuvant potential in immunization against influenza. The prepared ISCOMATRIX (ISC) and chitosan-coated ISCOMATRIX (ISC-CIT) showed a particle size of 171 and 233 nm with a zeta potential of -9.47 and +5.65, respectively. Furthermore, ISC-CIT formulations were co-administered with PR8 antigen (PR8-ISC-CIT) and their immunogenicity was investigated after intranasal and intramuscular immunization of BALBc/mice...
April 24, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29687966/spinal-manipulation-combined-with-laser-therapy-is-more-beneficial-than-laser-therapy-alone-in-chronic-non-specific-low-back-pain-a-randomized-controlled-study
#20
Gopal N Subash Chandra Bose, Walid Kamal, Shanmugananth Es, Siddhart Joshi, Parth Trivedi
BACKGROUND: Low back pain (LBP) is a common musculoskeletal disorder causing pain and disability in most of the countries. In recent years, new approaches such as Spinal manipulation and laser therapy have been considered as an alternative to conventional exercise and also found contradicting results in terms of its effectiveness. AIM: A study to compare the combined effects of spinal manipulation, Laser and exercise versus Laser and exercise alone in chronic non-specific low back pain (cnLBP)...
April 24, 2018: European Journal of Physical and Rehabilitation Medicine
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