keyword
MENU ▼
Read by QxMD icon Read
search

Adjuvants

keyword
https://www.readbyqxmd.com/read/29474901/arachidonic-acid-metabonomics-study-for-understanding-therapeutic-mechanism-of-huo-luo-xiao-ling-dan-on-rat-model-of-rheumatoid-arthritis
#1
Nannan Wang, Xiaoning Zhao, Jiaxin Huai, Yiran Li, Congcong Cheng, Kaishun Bi, Ronghua Dai
ETHNOPHARMACOLOGICAL RELEVANCE: Huo Luo Xiao Ling Dan (HLXLD), a traditional Chinese medicine (TCM), is commonly used for the treatment of rheumatoid arthritis (RA). AIM OF THE STUDY: To explore the potential therapeutic mechanism of HLXLD on anti-inflammatory activity. MATERIALS AND METHODS: A metabolomic approach based on UFLC-MS/MS to profile arachidonic acid (AA) metabolic changes was used. The cyclooxygenase (COX) and lipoxygenase (LOX) catalyzed metabolites in plasma were quantified on 7, 14, 21, and 28 days after the rats injected with Complete Freund's adjuvant and orally administrated with HLXLD, methotrexate and dexamethasone in parallel as the positive control drugs...
February 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29474271/de-escalation-treatment-of-human-papillomavirus-positive-oropharyngeal-squamous-cell-carcinoma-an-evidence-based-review-for-the-locally-advanced-disease
#2
Gustavo T Stock, Renata R C Colombo Bonadio, Gilberto de Castro
PURPOSE OF REVIEW: Oropharyngeal cancer (OPC) incidence is increasing worldwide, especially in developed countries where it seems to be etiologically related to the elevating rates of high-risk human papillomavirus (HPV) infection. Considered a distinct disease because of its weak correlation with the traditional risk factors (tobacco use and alcohol), it has different patterns of survival outcomes, locoregional and distant failure, generally with better prognosis independently of the treatment...
February 22, 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29474160/generating-a-battery-of-monoclonal-antibodies-against-firefly-luciferase-for-dot-blot-analysis-western-blot-analysis-and-immunostaining-of-cells-in-culture-and-paraffin-sections
#3
Thomas P Conway, Karla J Daniels, Yang-Nim Park, David R Soll
Firefly luciferase (FLuc) is commonly used as a reporter gene PpyLuc1 in bioanalytical assays. We have produced five mouse-derived monoclonal antibodies (mAbs) that recognize FLuc. The mAbs, DSHB-LUC-2, DSHB-LUC-3, DSHB-LUC-9, DSHB-LUC-16, and DSHB-LUC-24, were generated by immunizing mice with purified 6xHIS-tagged FLuc (6xHis-FLuc) in suspension with an adjuvant. All five were validated by dot blots. Four of the mAbs provided strong signals in western blot analysis, and one a weak signal. All five were validated for immunostaining in fixed cell culture...
February 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29474004/image-guided-surgery-in-cancer-a-strategy-to-reduce-incidence-of-positive-surgical-margins
#4
REVIEW
Kathryn R Tringale, John Pang, Quyen T Nguyen
Primary treatment for many solid cancers includes surgical excision or radiation therapy, with or without the use of adjuvant therapy. This can include the addition of radiation and chemotherapy after primary surgical therapy, or the addition of chemotherapy and salvage surgery to primary radiation therapy. Both primary therapies, surgery and radiation, require precise anatomic localization of tumor. If tumor is not targeted adequately with initial treatment, disease recurrence may ensue, and if targeting is too broad, unnecessary morbidity may occur to nearby structures or remaining normal tissue...
February 23, 2018: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/29473992/radical-prostatectomy-and-the-effect-of-close-surgical-margins-results-from-the-search-database
#5
Christine Herforth, Sean P Stroup, Zinan Chen, Lauren E Howard, Stephen J Freedland, Daniel M Moreira, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Christopher J Kane
OBJECTIVE: Positive surgical margins (PSM) after radical prostatectomy (RP) are a significant predictor of biochemical failure and possible disease progression. Close surgical margins (CSM) however represent a diagnostic challenge for surgeons. We sought to evaluate the biochemical recurrence (BCR) patterns among men undergoing RP with specimens having negative, positive, and close surgical margins from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. METHODS: Men undergoing RP between 1988 and 2015 with known final pathologic margin status were evaluated...
February 23, 2018: BJU International
https://www.readbyqxmd.com/read/29473967/importance-of-wide-re-resection-in-adult-spermatic-cord-sarcomas-report-on-oncologic-outcomes-at-a-single-institution
#6
Katie S Murray, Emily A Vertosick, Massimiliano Spaliviero, Joseph W Mashni, Daniel D Sjoberg, Kaled M Alektiar, Harry W Herr, Paul Russo, Jonathan A Coleman
BACKGROUND AND OBJECTIVES: We evaluated the effect of re-resection with wide margins (undertaken because initial resection performed elsewhere was incomplete) on survival in patients with spermatic cord sarcoma (SCS). METHODS: After excluding those with metastatic disease and those not undergoing surgical intervention, the records of 72 consecutive patients treated for SCS between 1981 and 2011 at Memorial Sloan Kettering Cancer Center were reviewed. Recurrence-free survival (RFS) and cancer-specific survival were calculated using the Kaplan-Meier method for comparing between the 48 patients who underwent wide re-resection (WRR) within 5 months of diagnosis and the 24 who did not...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473959/reconstruction-using-a-constrained-type-hip-tumor-prosthesis-after-resection-of-malignant-periacetabular-tumors-a-study-by-the-japanese-musculoskeletal-oncology-group-jmog
#7
Koichi Ogura, Michiro Susa, Hideo Morioka, Akihiko Matsumine, Takeshi Ishii, Kenichiro Hamada, Takafumi Ueda, Akira Kawai
BACKGROUND: We conducted a nationwide survey of prosthetic reconstruction using a constrained-type hip tumor prosthesis (C-THA) following resection of periacetabular tumors. METHODS: Eighty patients with periacetabular tumors underwent wide resection and prosthetic reconstruction using C-THA at JMOG-affiliated institutions (39 males and 41 females; mean age, 46.7 years; mean follow-up period, 65 months). Primary bone or soft tissue sarcoma accounted for 75% of the cases...
February 23, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29473933/assessment-of-genetic-integrity-splenic-phagocytosis-and-cell-death-potential-of-z-4-1-5-dimethyl-3-oxo-2-phenyl-2-3dihydro-1h-pyrazol-4-yl-amino-4-oxobut-2-enoic-acid-and-its-effect-when-combined-with-commercial-chemotherapeutics
#8
Rodrigo Juliano Oliveira, Naiara da Cruz Leite Santos, João Renato Pesarini, Beatriz Carneiro de Oliveira, Claudia Rodrigues Berno, Flávio Henrique Souza de Araújo, Ingridhy Ostaciana Maia Freitas da Silveira, Raquel Oliveira Nascimento, Andréia Conceição Milan Brochado Antoniolli-Silva, Antônio Carlos Duenhas Monreal, Adilson Beatriz, Dênis Pires de Lima, Roberto da Silva Gomes
The increased incidence of cancer and its high treatment costs have encouraged the search for new compounds to be used in adjuvant therapies for this disease. This study discloses the synthesis of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid (IR-01) and evaluates not only the action of this compound on genetic integrity, increase in splenic phagocytosis and induction of cell death but also its effects in combination with the commercial chemotherapeutic agents doxorubicin, cisplatin and cyclophosphamide...
February 19, 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29473768/comparison-of-definitive-intent-finely-fractionated-and-palliative-intent-coarsely-fractionated-radiotherapy-as-adjuvant-treatment-of-feline-microscopic-injection-site-sarcoma
#9
Federica Rossi, Laura Marconato, Silvia Sabattini, Simona Cancedda, Paola Laganga, Vito F Leone, Carla Rohrer Bley
Objectives The aim of this retrospective, bi-institutional study was to evaluate the progression-free interval in a cohort of cats with postoperative microscopic injection-site sarcoma (ISS) treated with two different radiotherapy protocols. Methods Included in the study were cats with ISSs undergoing macroscopic surgical removal and subsequent electron beam radiotherapy treatment with either a finely fractionated protocol (48 or 52.8 Gy over 4 weeks delivered in 12 or 16 fractions) or a coarsely fractionated protocol (36 Gy over 3 weeks administered in six fractions)...
February 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29473530/allergoids-for-allergy-treatment
#10
Jeronimo Carnes, Maria T Gallego, Raquel Moya, Victor Iraola
Background Chemically modified allergen extracts, known as allergoids, are commonly used for treating allergic patients. In general terms, the concept of allergoids implies allergen extracts with a reduction of their allergenicity maintaining their immunogenicity. Different methods to obtain allergoids have been developed in the past years, opening attractive lines of research. Objective To review the different approaches to allergoid development as well as their characterization, mechanism of action and efficacy and safety issues...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29473458/hyperbaric-oxygen-as-an-adjuvant-to-temozolomide-nanoparticle-inhibits-glioma-growth-by-inducing-g2-m-phase-arrest
#11
Yuanyuan Xie, Xiaofan Zeng, Xian Wu, Jun Hu, Yanhong Zhu, Xiangliang Yang
AIM: To study the effects of combinational treatment of hyperbaric oxygen (HBO) and nanotemozolomide in glioma. MATERIALS & METHODS: Temozolomide (TMZ)-loaded porous silicon nanoparticles (TMZ/PSi NPs) were prepared. In vitro and in vivo evaluations were performed. RESULTS: The cell uptake of TMZ/PSi NPs could be tracked by autofluorescence of porous silicon. The concentration of oxygen in tumor was improved and the antitumor rate was increased to 84...
February 23, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29473456/peripheral-somatosensory-stimulation-and-postural-recovery-after-stroke-a-systematic-review
#12
Jonas Schröder, Steven Truijen, Tamaya Van Criekinge, Wim Saeys
Purpose It is hypothesized that peripheral somatosensory stimulation (PSS) can promote postural recovery after stroke by increasing afferent input and postural contribution of the paretic leg. Therefore, this systematic review aims to investigate which PSS approaches are documented and investigated on effectiveness. Methods Five databases (PubMed, Web of Science, PEDro, Cochrane Library Trials, RehabData) have been searched on clinical studies in stroke rehabilitation, investigating PSS, which is defined as a non-motor and focal stimulation to the paretic leg aiming an increase in somatosensory input...
February 23, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29473335/leptomeningeal-enhancement-on-preoperative-brain-mri-in-patients-with-glioblastoma-and-its-clinical-impact
#13
Hakyoung Kim, Do Hoon Lim, Tae Gyu Kim, Jung-Il Lee, Do-Hyun Nam, Ho Jun Seol, Doo-Sik Kong, Jung Won Choi, Yeon-Lim Suh, Sung Tae Kim
AIM: Leptomeningeal enhancement (LME) on preoperative brain magnetic resonance imaging (MRI) does not always indicate leptomeningeal seeding (LMS). With Stupp's regimen, authors have treated glioblastoma patients with LME on preoperative brain MRI but here we tried to find the clinical impact of LME. METHODS: From 2005 to 2015, 290 patients with glioblastoma have been treated with Stupp's regimen at Samsung Medical Center. Among these, 33 patients showed LME on preoperative brain MRI...
February 23, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29473326/prediction-of-radiotherapy-response-with-a-5-microrna-signature-based-nomogram-in-head-and-neck-squamous-cell-carcinoma
#14
Lin Chen, Yihui Wen, Jingwei Zhang, Wei Sun, Vivian W Y Lui, Yi Wei, Fenghong Chen, Weiping Wen
Radiotherapy is unlikely to benefit all patients with head and neck squamous cell carcinoma (HNSCC). Therefore, novel method is warranted to predict the radiotherapy response. Our study aimed to construct a microRNA (miRNA)-based nomogram to predict clinical outcomes of patients with HNSCC receiving radiotherapy. We screened out 56 differential miRNAs by analyzing 44 paired tumor and adjacent normal samples miRNA expression profiles from The Cancer Genome Atlas (TCGA). A total of 307 patients with HNSCC receiving adjuvant radiotherapy were randomly divided into a training set (n = 154) and a validation set (n = 153)...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29473265/cytotoxic-t-lymphocyte-response-to-peptide-vaccination-predicts-survival-in-stage-iii-colorectal-cancer
#15
Junichiro Kawamura, Fumiaki Sugiura, Yasushi Sukegawa, Yasumasa Yoshioka, Jin-Ichi Hida, Shoichi Hazama, Kiyotaka Okuno
We previously reported a phase I clinical trial of a peptide vaccine ring finger protein 43 (RNF43) and 34-kDa translocase of the outer mitochondrial membrane (TOMM34) combined with uracil-tegafur (UFT)/LV for patients with metastatic colorectal cancer (CRC), and demonstrated the safety and immunological responsiveness of this combination therapy. In this study, we evaluated vaccination-induced immune responses to clarify the survival benefit of the combination therapy as adjuvant treatment. We enrolled 44 patients initially in an HLA-masked fashion...
February 23, 2018: Cancer Science
https://www.readbyqxmd.com/read/29473135/immunomodulatory-effects-of-cp-25-on-splenic-t-cells-of-rats-with-adjuvant-arthritis
#16
Yang Wang, Chen-Chen Han, Dongqian Cui, Ting-Ting Luo, Yifan Li, Yuwen Zhang, Yang Ma, Wei Wei
Rheumatoid arthritis (RA) is an autoimmune disease in which T cells play an important role. Paeoniflorin-6-oxy-benzenesulfonate (CP-25) shows a strong anti-inflammatory and immunomodulatory effect in the joint of adjuvant arthritis (AA) rats, but the role of the spleen function is still unclear. The aim of this study was to research how CP-25 regulated spleen function of AA rats. Male Sprague-Dawley rats were administered with CP-25 (50 mg/kg) orally from day 17 to 29 after immunization. The spleen histopathological changes were analyzed by hematoxylin-eosin staining...
February 23, 2018: Inflammation
https://www.readbyqxmd.com/read/29472700/neuroprotective-agents-in-the-management-of-glaucoma
#17
REVIEW
C Nucci, A Martucci, C Giannini, L A Morrone, G Bagetta, R Mancino
Glaucoma is an optic neuropathy, specifically a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. The pathogenesis of RGC loss in glaucoma remains incompletely understood and a broad range of possible mechanisms have been implicated. Clinical evidence indicates that lowering intraocular pressure (IOP) does not prevent progression in all patients; therefore, risk factors other than those related to IOP are involved in the disease. The need for alternative, non-IOP-lowering treatments focused at preventing progression, that is, neuroprotectants, has become of interest to both the patient and the physician...
February 23, 2018: Eye
https://www.readbyqxmd.com/read/29472591/early-sclerostin-expression-explains-bone-formation-inhibition-before-arthritis-onset-in-the-rat-adjuvant-induced-arthritis-model
#18
Guillaume Courbon, Raphaëlle Lamarque, Maude Gerbaix, Robin Caire, Marie-Thérèse Linossier, Norbert Laroche, Mireille Thomas, Thierry Thomas, Laurence Vico, Hubert Marotte
Periarticular bone loss in rheumatoid arthritis (RA) is considered to be mainly related to synovial inflammation. However, strong bone loss has also described at the time of arthritis onset. Recently, a paradoxical exacerbation of joint damage was described when blocking sclerostin in various arthritis models. Thus, we aimed to determine kinetics of bone loss and its mechanisms in the adjuvant induced arthritis (AIA) rat model of RA. AIA was induced (n = 35) or not (n = 35) at day 0. In addition to well-known arthritis at day 12, we showed with 3D-imaging and histomorphometry that bone microstructural alterations occurred early from day 8 post-induction, characterized by cortical porosity and trabecular bone loss...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29472064/major-postoperative-complications-compromise-oncological-outcomes-of-patients-with-intrahepatic-cholangiocarcinoma-after-curative-resection-a-13-year-cohort-in-a-tertiary-center
#19
Ka Wing Ma, Tan To Cheung, Wong Hoi She, Kenneth Siu Ho Chok, Albert Chi Yan Chan, Wing Chiu Dai, Simon Hin Yin Tsang, Chung Mau Lo
BACKGROUND/OBJECTIVE: Hepatectomy is the mainstay of curative treatment for intrahepatic cholangiocarcinoma (ICC). The relationship between postoperative complication and oncological outcome has not been defined. We aimed to elucidate the effect of postoperative complication on long-term survival of ICC patients after curative resection. METHODS: Data of consecutive patients who had curative resection for ICC at our hospital from 1991 to 2013 were reviewed. Patients with cholangiohepatocellular carcinoma, metastatic adenocarcinoma or Klaskin tumor were excluded...
February 19, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29472043/neoadjuvant-and-adjuvant-strategies-in-retroperitoneal-sarcoma
#20
REVIEW
L Max Almond, Alessandro Gronchi, Dirk Strauss, Mariam Jafri, Samuel Ford, Anant Desai
Extended surgery remains the mainstay of treatment in retroperitoneal sarcoma, although conflicting data exist on the benefit of neoadjuvant and adjuvant therapies, particularly with regard to tumour grade and histological type. Experience of radiotherapy and chemotherapy in extremity soft tissue sarcoma can inform treatment strategies, however these data cannot be universally extrapolated to the retroperitoneum where disease biology and anatomical considerations are different. The present review sets a historical context before discussing recent evidence and on-going multi-centre trials in retroperitoneal sarcoma...
February 9, 2018: European Journal of Surgical Oncology
keyword
keyword
109649
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"