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Z Chen, L Cheng, G Feng
Chronic recurrent multifocal osteomyelitis (CRMO) is a sporadic condition of inflammatory bone pain that occurs as recurrent flares because of osteomyelitis, which presents in the form of multiple aseptic foci. The estimated prevalence of CRMO is 1-2 per million, affecting mostly children, in the age group of 2 to 17. Main symptoms of CRMO are bone inflammation and pain, which are generally worse at night. Other symptoms seen on radiographs indicate osteolytic lesions surrounded by sclerosis, at later stages of the disease...
March 2018: European Review for Medical and Pharmacological Sciences
Gianvincenzo Sparacia, Francesco Agnello, Angelo Gambino, Martina Sciortino, Massimo Midiri
Purpose The aim of this study was to determine the occurrence and distribution of the 'central vein' sign in white matter lesions on susceptibility-weighted magnetic resonance images in patients with multiple sclerosis (MS) and cerebral small vessel disease (CSVD). Materials and methods T2-weighted and fluid-attenuated inversion recovery magnetic resonance images of 19 MS patients and 19 patients affected by CSVD were analysed for the presence and localisation of focal hyperintense white matter lesions. Lesions were subdivided into periventricular or non-periventricular (juxtacortical, subcortical, deep white matter and cerebellar) distributed...
January 1, 2018: Neuroradiology Journal
Irene Ródenas Esteve, Carmina Wanden-Berghe, Javier Sanz-Valero
OBJECTIVE: To review the available scientific literature about the effects of nutritional status on the multiple sclerosis disease. METHODS: A systematic review of the scientific literature in the Medline (PubMed), Scopus, Cochrane Library and Web of Science databases through November 2016. Search equation: ("Multiple Sclerosis"[Mesh] OR "Multiple Sclerosis"[Title/Abstract] OR "Disseminated Sclerosis"[Title/Abstract] OR "Multiple Sclerosis Acute Fulminating"[Title/Abstract]) AND ("Nutritional Status"[Mesh] OR "Nutritional Status"[Title/Abstract] OR "Nutrition Status"[Title/Abstract])...
January 19, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Erandis D Torres-Sánchez, Fermín P Pacheco-Moisés, Miguel A Macias-Islas, Eddic W Morales-Sánchez, Viridiana Ramírez-Ramírez, Alfredo J Celis de la Rosa, Margarita Cid-Hernández, Tanya E Sorto-Gómez, Genaro G Ortiz
BACKGROUND: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with increased oxidative stress (OS) and mitochondrial alterations. Fish oil consumption has neuroprotective, antioxidant and anti-inflammatory effects in patients with relapsing-recurrent MS (RR-MS). OBJECTIVE: To evaluate changes in the hydrolytic activity of ATP synthase and mitochondrial membrane fluidity in patients with RR-MS who receive fish oil or olive oil as a dietary supplement...
January 12, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
The Lancet
No abstract text is available yet for this article.
March 17, 2018: Lancet
Eric Thouvenot, Geoffrey Hinsinger, Christophe Demattei, Ugur Uygunoglu, Giovanni Castelnovo, Sophie Pittion-Vouyovitch, Darin Okuda, Orhun Kantarci, Daniel Pelletier, Sylvain Lehmann, Philippe Marin, Aksel Siva, Christine Lebrun
BACKGROUND: Younger age, male sex and presence of spinal cord lesion(s) increase the risk of conversion from radiologically isolated syndrome (RIS) to relapsing-remitting multiple sclerosis (RRMS). Elevated cerebrospinal fluid (CSF) chitinase-3-like protein 1 (CHI3L1) levels predict conversion from clinically isolated syndrome (CIS) to RRMS. OBJECTIVE: To evaluate the prognostic value of CSF CHI3L1 in RIS patients for conversion to RRMS. METHODS: We compared CSF CHI3L1 concentrations in RIS, CIS, RRMS and symptomatic controls (SCs)...
March 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
Yongping Chen, Bei Cao, Ruwei Ou, Qianqian Wei, Xueping Chen, Bi Zhao, Ying Wu, Wei Song, Hui-Fang Shang
Large-scale meta-analyses of genome-wide association studies have identified several loci linked to sporadic Parkinson's disease (PD). However, the roles of some important loci, such as HNMT Thr105Ile, STK39 rs2390669, and NMD3 rs34016896, have not been clarified in Chinese populations. Accumulating evidence indicates that some common clinicopathological characteristics are shared by different neurodegenerative diseases. Consequently, we conducted a large sample study to investigate associations between these variants and PD, multiple system atrophy (MSA), and amyotrophic lateral sclerosis (ALS) in Chinese populations...
March 21, 2018: Journal of Molecular Neuroscience: MN
Jeffrey Lambe, Olwen C Murphy, Shiv Saidha
PURPOSE OF REVIEW: With the recognition that neurodegeneration represents the principal substrate of disability in multiple sclerosis (MS), there has been increased strives towards identifying biomarkers for accurately quantifying and tracking neurodegeneration during the disease course. The retina provides an opportune "window" into the central nervous system (CNS) in MS, with retinal changes in MS reflecting not only local, but also global aspects of neurodegeneration and inflammation operative in the disease...
March 21, 2018: Current Treatment Options in Neurology
Astrid Eliasen, Kim Peder Dalhoff, Henrik Horwitz
INTRODUCTION: Neurological diseases have a profound impact on quality of life. We investigated the risk of suicide attempt in ten neurological diseases. METHODS: Case-control study. Cases were identified from the Danish Poison Information Centre database in the period 2006-2013. The prevalence of ten neurological diagnoses was compared with the prevalence in a randomly sampled age- and gender-matched control group. RESULTS: We identified 8974 cases of suicidal attempt and 89,740 controls...
March 21, 2018: Journal of Neurology
Ola Nakken, Jonas Christoffer Lindstrøm, Trygve Holmøy
Increasing female: male ratio in multiple sclerosis (MS) has been assigned to cohort effects, with females in more recent birth cohorts possibly being more exposed or vulnerable to environmental risk factors than males. We collected MS mortality data in Norway from 1951 to 2015 from The Norwegian Cause of Death registry. Age-Period-Cohort analysis was conducted using log-linear Poisson models, including sex interaction terms. MS was registered as the underlying, contributing or direct cause in 6060 deaths. MS associated mortality remained stable with a slight preponderance among males until after 1980, and have since increased preferentially among females...
March 21, 2018: Journal of Neurology
Veit Rothhammer, Davis M Borucki, Jessica E Kenison, Patrick Hewson, Zhongyan Wang, Rohit Bakshi, David H Sherr, Francisco J Quintana
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with important functions in the immune response and cancer. AHR agonists are provided by the environment, the commensal flora and the metabolism. Considering AHR physiological functions, AHR agonists may have important effects on health and disease. Thus, the quantification of AHR agonists in biological samples is of scientific and clinical relevance. We compared different reporter systems for the detection of AHR agonists in serum samples of Multiple Sclerosis (MS) patients, and assessed the influence of transfection methods and cell lines in a reporter-based in vitro assay...
March 21, 2018: Scientific Reports
Linard Filli, Tabea Sutter, Christopher S Easthope, Tim Killeen, Christian Meyer, Katja Reuter, Lilla Lörincz, Marc Bolliger, Michael Weller, Armin Curt, Dominik Straumann, Michael Linnebank, Björn Zörner
Gait dysfunction is a common and relevant symptom in multiple sclerosis (MS). This study aimed to profile gait pathology in gait-impaired patients with MS using comprehensive 3D gait analysis and clinical walking tests. Thirty-seven patients with MS walked on the treadmill at their individual, sustainable speed while 20 healthy control subjects walked at all the different patient's paces, allowing for comparisons independent of walking velocity. Kinematic analysis revealed pronounced restrictions in knee and ankle joint excursion, increased gait variability and asymmetry along with impaired dynamic stability in patients...
March 21, 2018: Scientific Reports
Kerstin Göbel, Christoph Kleinschnitz, Sven G Meuth
Multiple sclerosis (MS) is one of the most emerging fields in neurology[...].
March 19, 2018: International Journal of Molecular Sciences
Jacob Callesen, Davide Cattaneo, John Brincks, Ulrik Dalgas
INTRODUCTION: Multiple sclerosis (MS) is characterized by a demyelination that results in reduced conductivity in the somatosensory nervous system, decreased muscle strength, vestibular alteration, and severe fatigue. Progressive resistance training (PRT) has proven to be a promising intervention showing a positive effect on muscle strength. Another promising intervention frequently used in neuro-rehabilitation is task specific training where also Balance and Motor Control Training (BMCT) are incorporated...
2018: NeuroRehabilitation
Francesca Bagnato, Simon Hametner, Emma Boyd, Verena Endmayr, Yaping Shi, Vasiliki Ikonomidou, Guanhua Chen, Siddharama Pawate, Hans Lassmann, Seth Smith, E Brian Welch
T2*-weighted multi-echo gradient-echo magnetic resonance imaging and its reciprocal R2* are used in brain imaging due to their sensitivity to iron content. In patients with multiple sclerosis who display pathological alterations in iron and myelin contents, the use of R2* may offer a unique way to untangle mechanisms of disease. Coronal slices from 8 brains of deceased multiple sclerosis patients were imaged using a whole-body 7.0 Tesla MRI scanner. The scanning protocol included three-dimensional (3D) T2*-w multi-echo gradient-echo and 2D T2-w turbo spin echo (TSE) sequences...
2018: PloS One
Matilde Inglese, Maria Petracca
PURPOSE OF REVIEW: Clinical MRI is of paramount importance for multiple sclerosis diagnosis but lacks the specificity to investigate the pathogenic mechanisms underlying disease onset and progression. The application of advanced magnetic resonance (MR) sequences allows the characterization of diverse and complex pathological mechanisms, granting insights into multiple sclerosis natural history and response to treatment. RECENT FINDINGS: This review provides an update on the most recent international guidelines for optimal standard imaging of multiple sclerosis and discusses advantages and limitations of advanced imaging approaches for investigating inflammation, demyelination and neurodegeneration...
March 19, 2018: Current Opinion in Neurology
Anne-Katrin Pröbstel, Stephen L Hauser
No abstract text is available yet for this article.
March 20, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Leos Landa, Jan Jurica, Jiri Sliva, Monika Pechackova, Regina Demlova
The use of cannabis for medical purposes has been recently legalised in many countries including the Czech Republic. As a result, there is increased interest on the part of physicians and patients in many aspects of its application. This mini review briefly covers the main active substances of the cannabis plant and mechanisms of action. It focuses on two conditions, cancer pain and spasticity in multiple sclerosis, where its effects are well-documented. A comprehensive overview of a few cannabis-based products and the basic pharmacokinetics of marijuana's constituents follows...
March 19, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Julie Mouchet, Bernard Bégaud
INTRODUCTION: Hepatitis B (HB) vaccination programs were set up worldwide in the early 1990s. Despite their major focus on reducing the burden of HB infection, they have seldom achieved the targeted population coverage in most countries, including the USA, with around 24.5% of adults being vaccinated against HB. Among proposed reasons for this is the persisting doubt about a possible link between HB vaccination and the occurrence of cases of multiple sclerosis (MS). OBJECTIVE: Our objective was to evaluate a potential safety signal between MS and HB vaccination...
March 20, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
David H Miller, Fred D Lublin, Maria Pia Sormani, Ludwig Kappos, Özgür Yaldizli, Mark S Freedman, Bruce A C Cree, Howard L Weiner, Catherine Lubetzki, Hans-Peter Hartung, Xavier Montalban, Bernard M J Uitdehaag, David G MacManus, Tarek A Yousry, Claudia A M Gandini Wheeler-Kingshott, Bingbing Li, Norman Putzki, Martin Merschhemke, Dieter A Häring, Jerry S Wolinsky
Objective: To investigate the relationship between brain volume and disability worsening over ≥3 years in the natural history of primary progressive multiple sclerosis using data from the placebo group of the INFORMS trial ( n  = 487; NCT00731692). Methods: Magnetic resonance imaging scans were collected annually. Brain volume loss was determined using SIENA. Patients were stratified by baseline normalized brain volume after adjusting for demographic and disease-burden covariates...
March 2018: Annals of Clinical and Translational Neurology
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