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https://www.readbyqxmd.com/read/29232103/game-changers-new-%C3%AE-lactamase-inhibitor-combinations-targeting-antibiotic-resistance-in-gram-negative-bacteria
#1
Karen Bush
Recent regulatory approvals for the β-lactam inhibitor combinations of ceftazidime-avibactam and meropenem-vaborbactam have provided two novel therapeutic options for the treatment of multidrug-resistant infections caused by Gram-negative bacteria. Most importantly, these combination agents have satisfied an important medical need related to antibiotic-resistant Klebsiella pneumoniae that produce serine carbapenemases, especially the Klebsiella pneumoniae carbapenemase (KPC) enzymes. Both combinations contain non-β-lactam β-lactamase inhibitors of novel chemical classes not previously developed as antibacterial agents, the diazabicyclooctanes and cyclic boronic acid derivatives...
December 12, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29231755/pharmaceutical-aspects-of-silver-nanoparticles
#2
Prateek Mathur, Swati Jha, Suman Ramteke, N K Jain
Silver nanoparticles are particles in the size ranging between 1 and 100 nm. The two major methods used for synthesis of silver nanoparticle are the physical and chemical methods with the disadvantage that they are expensive and can also have toxicity. Biological method is being used as an expedient alternative, as this approach is environment-friendly and less toxic and it includes plant extracts, microorganism, fungi, etc. The major applications of silver nanoparticles in the medical field include diagnostic applications and therapeutic applications, apart from its antimicrobial activity...
December 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29231444/-analysis-on-property-of-meridian-supramolecules-by-biological-evolution-path
#3
Kaiwen Deng, Yeqin Tao, Wenhan Tang, Fuyuan He, Wenlong Liu, Jilian Shi, Yantao Yang, Yiqun Zhou, Xiaorong Chang
With human placed in the whole nature, by following the biologic evolution path, the property of channel structure for "imprinting template" in meridian and zang-fu was explored with supramolecular chemistry. In the history of biologic evolution, each molecule in "molecule society" gradually developed into various highly-ordered supramolecular bodies based on self-identification, self-assembly, self-organization, self-replicating of"imprinting template", and thereby the original biochemical system was established, and finally evolved into human...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230418/an-overview-of-the-biological-effects-of-some-mediterranean-essential-oils-on-human-health
#4
REVIEW
Hazem S Elshafie, Ippolito Camele
Essential oils (EOs), extracted from aromatic plants, are interesting natural products and represent an important part of the traditional pharmacopeia. The use of some EOs as alternative antimicrobial and pharmaceutical agents has attracted considerable interest recently. Most of the EOs and their single constituents have been reported to inhibit several phytopathogens, human pathogens, and insects as well as their effective uses in food and pharmaceutical industries. The current review discussed the chemical composition and bioactivity of some important EOs extracted from some Mediterranean plants and their principal bioactive single constituents...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29229242/synthesis-characterisation-and-biomedical-applications-of-curcumin-conjugated-chitosan-microspheres
#5
T S Saranya, V K Rajan, Raja Biswas, R Jayakumar, S Sathianarayanan
Curcumin is a diaryl heptanoid of curcuminoids class obtained from Curcuma longa. It possesses various biological activities like anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities. Chitosan is a biocompatible, biodegradable and non-toxic natural polymer which enhances the adhesive property of the skin. Chemical conjugation will leads to sustained release action and to enhance the bioavailability. This study aims to synthesis and characterize biocompatible curcumin conjugated chitosan microspheres for bio-medical applications...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29227272/-study-of-some-plant-seed-lipids-growing-in-georgia
#6
B Kikalishvili, N Gorgaslidze, Ts Sulakvelidze, M Malania, N Urushadze, D Turabelidze
The purpose of the research was to study seed lipids of cultivated plants: Medicago sativa, Ruta graveolens L., Linum usitatissimum L., which are growing on experimental field of I. Kutateladze Institute of Pharmacochemistry. From the above-mentioned plant seeds was obtained the sum of neutral and polar lipids, the classes were determined qualitatively. Using standard methods were determined some physico-chemical constant of oils. Fatty acids was established qualitatively and was determined quantitatively using Gas chromatography and High performance liquid chromatography methods...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29225514/elevation-of-small-dense-low-density-lipoprotein-cholesterol-a-possible-antecedent-of-atherogenic-lipoprotein-phenotype-in-type-2-diabetes-patients-in-jos-north-central-nigeria
#7
Kenneth O Inaku, Obasola O Ogunkeye, Fayeofori M Abbiyesuku, Evelyn K Chuhwak, Christian O Isichei, Lucius C Imoh, Noel O Amadu, Alexander O Abu
Background: The global prevalence of type 2 diabetes is increasing. Dyslipidaemia is a known complication of diabetes mellitus manifesting frequently as cardiovascular diseases and stoke. Elevation of small, dense low density lipoprotein has been recognised as a component of the atherogenic lipoprotein phenotype associated with cardiovascular complications. We speculate that the elevation of this lipoprotein particle may be the antecedent of the atherogenic lipoprotein phenotype. This study therefore aims to determine the pattern of dyslipidaemia among diabetes mellitus patients in Jos, North-Central Nigeria...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29224759/dysphagia-and-feeding-difficulties-post-pediatric-ingestion-injury-perspectives-of-the-primary-caregiver
#8
Anna M Follent, Anna F Rumbach, Elizabeth C Ward, Jeanne Marshall, Pamela Dodrill, Peter Lewindon
PURPOSE: To explore the experiences of children with dysphagia and/or feeding difficulties post-chemical or button battery ingestion injury from the perspective of the primary caregiver. METHOD: Five primary caregivers of children with a history of dysphagia and/or feeding difficulties post-ingestion injury (4 chemical, 1 button battery) completed the Children's Picky Eating Questionnaire (CPEQ), and participated in a semi-structured interview. Interviews explored experiences of caring for a child with dysphagia and/or feeding difficulties, impressions of services and supports, and additional impacts to the child and family...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29223014/differentiation-of-dry-cured-hams-from-different-processing-methods-by-means-of-volatile-compounds-physico-chemical-and-sensory-analysis
#9
Sandra Petričević, Nives Marušić Radovčić, Katarina Lukić, Eddy Listeš, Helga Medić
The aim of this study was to characterize dry-cured hams from four different processing methods (differences in primary leg treatment, salting and smoking phase). Volatile compounds were isolated by using headspace-solid phase microextraction and analysed by gas chromatography/mass spectrometry (GC/MS). Samples were also evaluated by sensory and physico-chemical characteristics (moisture, protein, fat and NaCl content, aw, colour). 149 volatile compounds of dry-cured hams were identified and 15 of them were quantified...
December 5, 2017: Meat Science
https://www.readbyqxmd.com/read/29218953/-exploiture-and-application-of-an-internet-based-computation-platform-for-integrative-pharmacology-of-traditional-chinese-medicine
#10
Hai-Yu Xu, Zhen-Ming Liu, Yan Fu, Yan-Qiong Zhang, Jian-Jun Yu, Fei-Fei Guo, Shi-Huan Tang, Chuan-Yu Lv, Jin Su, Ru-Yi Cui, Hong-Jun Yang
Recently, integrative pharmacology(IP) has become a pivotal paradigm for the modernization of traditional Chinese medicines(TCM) and combinatorial drugs discovery, which is an interdisciplinary science for establishing the in vitro and in vivo correlation between absorption, distribution, metabolism, and excretion/pharmacokinetic(ADME/PK) profiles of TCM and the molecular networks of disease by the integration of the knowledge of multi-disciplinary and multi-stages. In the present study, an internet-based Computation Platform for IP of TCM(TCM-IP, www...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29215915/perspectives-on-the-relevance-of-the-circadian-time-structure-to-workplace-threshold-limit-values-and-employee-biological-monitoring
#11
Michael H Smolensky, Alain E Reinberg, Linda Sackett-Lundeen
The circadian time structure (CTS) and its disruption by rotating and nightshift schedules relative to work performance, accident risk, and health/wellbeing have long been areas of occupational medicine research. Yet, there has been little exploration of the relevance of the CTS to setting short-term, time-weighted, and ceiling threshold limit values (TLVs); conducting employee biological monitoring (BM); and establishing normative reference biological exposure indices (BEIs). Numerous publications during the past six decades document the CTS substantially affects the disposition - absorption, distribution, metabolism, and elimination - and effects of medications...
December 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29215258/plasma-functionalized-solution-a-potent-antimicrobial-agent-for-biomedical-applications-from-antibacterial-therapeutics-to-biomaterial-surface-engineering
#12
Joo Young Park, Sanghoo Park, Wonho Choe, Hae In Yong, Cheorun Jo, Kijung Kim
Deadly diseases caused by pathogenic bacteria and viruses have increasingly victimized humans; thus, the importance of disinfection has increased in medical settings as well as in food and agricultural industries. Plasma contains multiple bactericidal agents, including reactive species, charged particles, and photons, which can have synergistic effects. In particular, the chemicals formed in aqueous solution during plasma exposure have the potential for high antibacterial activity against various bacterial infections...
December 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29214549/synthesis-structure-and-toxicity-evaluation-of-ethanolamine-nitro-chloronitrobenzoates-a-combined-experimental-and-theoretical-study
#13
Manuela Crisan, Liliana Halip, Paulina Bourosh, Sergiu Adrian Chicu, Yurii Chumakov
BACKGROUND: Nitroaromatic and chloronitroaromatic compounds have been a subject of great interest in industry and recently in medical-pharmaceutic field. 2-Chloro-4-nitro/2-chloro-5-nitrobenzoic acids and 4-nitrobenzoic acid are promising new agents for the treatment of main infectious killing diseases in the world: immunodeficiency diseases and tuberculosis. RESULTS: New ethanolamine nitro/chloronitrobenzoates were synthesized and characterized by X-ray crystallography, UV-vis, FT-IR and elementary analysis techniques...
December 6, 2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/29214236/characterization-of-byproducts-from-chemical-syntheses-of-oligonucleotides-containing-1-methyladenine-and-3-methylcytosine
#14
Qi Tang, Ang Cai, Ke Bian, Fangyi Chen, James C Delaney, Sravani Adusumalli, Alvin C Bach, Fatemeh Akhlaghi, Bongsup P Cho, Deyu Li
Oligonucleotides serve as important tools for biological, chemical, and medical research. The preparation of oligonucleotides through automated solid-phase synthesis is well-established. However, identification of byproducts generated from DNA synthesis, especially from oligonucleotides containing site-specific modifications, is sometimes challenging. Typical high-performance liquid chromatography (HPLC), mass spectrometry (MS), and gel electrophoresis methods alone are not sufficient for characterizing unexpected byproducts, especially for those having identical or very similar molecular weight (MW) to the products...
November 30, 2017: ACS Omega
https://www.readbyqxmd.com/read/29214061/medical-thoracoscopy-and-its-evolving-role-in-the-diagnosis-and-treatment-of-pleural-disease
#15
REVIEW
Vivek Murthy, Jamie L Bessich
Establishing the etiology of exudative pleural effusions in the setting of an unrevealing pleural fluid analysis often requires biopsies from the parietal pleura. While closed pleural biopsy (CPB) has been a popular minimally-invasive approach, it has a poor diagnostic yield, barring a diagnosis of tuberculous pleurisy. Medical thoracoscopy (MT) is a minimally-invasive ambulatory procedure performed under local anesthesia or moderate sedation which allows for direct visualization of biopsy targets as well as simultaneous therapeutic interventions, including chemical pleurodesis and indwelling tunneled pleural catheter (ITPC) placement...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29206009/hydrotherapy-and-medical-entrepreneurship-the-water-spell-of-ricardo-jorge
#16
Rui Manuel Pinto Costa
Between 1886 and 1893, the doctor and hygienist Ricardo Jorge was linked to a commercial and medical project on the waters of Gerês. Known for many centuries and used for therapeutic purposes, they were administered on an empirical basis. When new chemical analyses were first published, the empirical properties of these waters took on a new role in hydrotherapy based on their now proven mineral and medicinal qualities. The article discusses in detail Ricardo Jorge's business venture, framing it in the context of the economic collection and treatment potential of mineral waters and the revival of the phenomenon of hydrotherapy, legitimized by new developments in the chemical analysis of waters...
2017: Dynamis
https://www.readbyqxmd.com/read/29201980/experimental-data-of-co-crystals-of-etravirine-and-l-tartaric-acid
#17
Mikal Rekdal, Aravind Pai, Muddukrishna Bs
Etravirine is a drug used alongside other medication in the treatment of HIV and is a non-nucleoside reverse transcriptase inhibitor. It is a BCS class IV drug, having low solubility and high permeability (Drugbank, https://www.drugbank.ca/drugs/DB06414) [1]. As a result, large doses of the drug are required for treatment. Two pills have to be taken twice a day, making it a "pill burden" (Intelence, http://www.intelence.com/hcp/dosing/administration-options) [2]. Therefore, attempts of co-crystallizing Etravirine are attractive as the solubility of the drug tends to increase in this solid form (Schultheiss and Newman, 2009) [3]...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29201559/genomic-characterization-of-a-new-endophytic-streptomyces-kebangsaanensis-identifies-biosynthetic-pathway-gene-clusters-for-novel-phenazine-antibiotic-production
#18
Juwairiah Remali, Nurul 'Izzah Mohd Sarmin, Chyan Leong Ng, John J L Tiong, Wan M Aizat, Loke Kok Keong, Noraziah Mohamad Zin
Background: Streptomyces are well known for their capability to produce many bioactive secondary metabolites with medical and industrial importance. Here we report a novel bioactive phenazine compound, 6-((2-hydroxy-4-methoxyphenoxy) carbonyl) phenazine-1-carboxylic acid (HCPCA) extracted from Streptomyces kebangsaanensis, an endophyte isolated from the ethnomedicinal Portulaca oleracea. Methods: The HCPCA chemical structure was determined using nuclear magnetic resonance spectroscopy...
2017: PeerJ
https://www.readbyqxmd.com/read/29201226/bronchial-damage-and-diffuse-alveolar-hemorrhage-following-chlorine-gas-inhalation-a-case-report
#19
Kosuke Uemura, Momoko Isono, Katsunori Kagohashi, Ryuichi Hasegawa, Hiroaki Satoh
Chlorine is a toxic inhalant and sources of exposure for individuals include accidental releases of chlorine vapor due to industrial or chemical transportation accidents. Inhalation of a large quantity of gas may cause circulatory and respiratory disorders or even mortality; however, the effects of a small amount of chlorine gas may be asymptomatic. The present case study presents a successfully treated 55-year-old male patient exposed to chlorine gas, resulting in bronchial damage and diffuse alveolar hemorrhage...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29199580/what-is-ganoderma-lucidum-in-the-molecular-era
#20
Viktor Papp, Bálint Dima, Solomon P Wasser
The scientific name Ganoderma lucidum has long been used in the global medicinal mushroom market, and many publications have proven its pharmacological properties and chemical components. Although several Ganoderma species have been described worldwide as having morphology considerably similar to that of G. lucidum s. str., this binomial is still the most frequently used in pharmacological studies. However, the use of particularly divergent nomenclature has caused major difficulties in the evaluation of the results of pharmacological studies...
2017: International Journal of Medicinal Mushrooms
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