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https://www.readbyqxmd.com/read/28634068/investigation-of-changes-in-endocannabinoids-and-n-acylethanolamides-in-biofluids-and-their-correlations-with-female-infertility
#1
Jun Ding, Xiao-Tong Luo, Yan-Ru Yao, Hua-Ming Xiao, Ming-Quan Guo
Female infertility is a worldwide medical problem, and the scarcity of infertility biomarkers has hindered the ability to launch preventive and therapeutic measures in a timely manner. Intriguingly, alterations in endocannabinoids (eCBs) and N-acylethanolamides (NAEs) have been observed in the biofluids of infertile females. Therefore, a hypothesis of using eCB and NAEs in biofluids as infertility biomarkers was proposed by several researchers; however, little evidence exists to verify the hypothesis. To investigate their correlations with female infertility, we developed a magnetic liquid microextraction-chemical derivatization (MLME-CD) method coupled with liquid chromatography-tandem mass spectrometry for the quantification of eCBs and NAEs in biofluids...
June 12, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28632821/encapsulated-islet-transplantation-where-do-we-stand
#2
Vijayaganapathy Vaithilingam, Sumeet Bal, Bernard E Tuch
Transplantation of pancreatic islets encapsulated within immuno-protective microcapsules is a strategy that has the potential to overcome graft rejection without the need for toxic immunosuppressive medication. However, despite promising preclinical studies, clinical trials using encapsulated islets have lacked long-term efficacy, and although generally considered clinically safe, have not been encouraging overall. One of the major factors limiting the long-term function of encapsulated islets is the host's immunological reaction to the transplanted graft which is often manifested as pericapsular fibrotic overgrowth (PFO)...
2017: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/28632490/the-florence-statement-on-triclosan-and-triclocarban
#3
Rolf U Halden, Avery E Lindeman, Allison E Aiello, David Andrews, William A Arnold, Patricia Fair, Rebecca E Fuoco, Laura A Geer, Paula I Johnson, Rainer Lohmann, Kristopher McNeill, Victoria P Sacks, Ted Schettler, Roland Weber, R Thomas Zoeller, Arlene Blum
The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban. These chemicals may be used in thousands of personal care and consumer products as well as in building materials. Based on extensive peer-reviewed research, this statement concludes that triclosan and triclocarban are environmentally persistent endocrine disruptors that bioaccumulate in and are toxic to aquatic and other organisms...
June 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28632200/the-beginning-and-development-of-the-theranostic-approach-in-nuclear-medicine-as-exemplified-by-the-radionuclide-pair-86-y-and-90-y
#4
Frank Rösch, Hans Herzog, Syed M Qaim
In the context of radiopharmacy and molecular imaging, the concept of theranostics entails a therapy-accompanying diagnosis with the aim of a patient-specific treatment. Using the adequate diagnostic radiopharmaceutical, the disease and the state of the disease are verified for an individual patient. The other way around, it verifies that the radiopharmaceutical in hand represents a target-specific and selective molecule: the "best one" for that individual patient. Transforming diagnostic imaging into quantitative dosimetric information, the optimum radioactivity (expressed in maximum radiation dose to the target tissue and tolerable dose to healthy organs) of the adequate radiotherapeutical is applied to that individual patient...
June 20, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28629957/chemical-hand-warmer-packet-ingestion-a-case-of-elemental-iron-exposure
#5
Jessica L Weiland, Leighanne K Sherrow, Deepak A Jayant, Kenneth D Katz
For individuals who work outdoors in the winter or play winter sports, chemical hand warmers are becoming increasingly more commonplace because of their convenience and effectiveness. A 32-year-old woman with a history of chronic pain and bipolar disorder presented to the emergency department complaining of a "warm sensation" in her mouth and epigastrium after reportedly ingesting the partial contents of a chemical hand warmer packet containing between 5 and 8 g of elemental iron. She had been complaining of abdominal pain for approximately 1 month and was prescribed unknown antibiotics the previous day...
June 16, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28629250/a-comparison-between-the-effects-of-ginger-pyridoxine-vitamin-b6-and-placebo-for-the-treatment-of-the-first-trimester-nausea-and-vomiting-of-pregnancy-nvp
#6
Fatemeh Sharifzadeh, Maryam Kashanian, Jalil Kouhpayehzadeh, Fatemeh Rezaian, Narges Sheikhansari, Nooshin Eshraghi
INTRODUCTION: Nausea and vomiting of pregnancy (NVP) are one of the most common complains of the early pregnancy period and are bothersome for pregnant women. Some prefer to use herbal medicine instead of chemical agents. OBJECTIVE: The purpose of the present study was to compare the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of NVP. METHOD: The study was performed as a triple blind clinical trial on pregnant women suffering mild to moderate NVP between 6-16 weeks of pregnancy...
June 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28629022/a-novel-functionalization-method-for-carbon-nanotubes-to-repel-ox-ldl-in-treatments-after-stent-placement
#7
C I Santana, L M Hoyos, J F Pérez, J Bustamante, A G García
Carbon nanotubes (CNT) can be chemically modified by doping or functionalization to change the chemical and surface properties. These characteristic makes to CNT candidates for multiple applications including medical field in cardiovascular area. A novel method to CNT functionalization by formation of two compounds: α-bromoacid and the organic compound 2-(methacryloyloxy) ethyl phosphorylcholine (MPC), will be discussed in this article. According to results, CNT are suggested like candidates to repel oxidized low-density lipoproteins (ox-LDL) to prevent restenosis...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628897/diverted-medications-and-new-psychoactive-substances-a-chemical-network-analysis-of-discarded-injecting-paraphernalia-in-hungary
#8
Valéria Anna Gyarmathy, Anna Péterfi, Tamás Figeczki, József Kiss, Katalin Medgyesi-Frank, János Posta, József Csorba
BACKGROUND: Until about 2010, people who inject drugs (PWIDs) injected almost exclusively heroin and amphetamines in Hungary. After 2010, self-reported studies have indicated a dominance of new psychoactive substances on the drug market for injectable drugs. METHODS: Between March 2015 and February 2016, we collected used and discarded injecting paraphernalia. We utilized chemical analysis to assess and UCINet to visualize the connections between the most prevalent main substances and their respective co-occurring additional components at 7 locations in Hungary...
June 16, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28627324/preparation-characterization-and-in-vitro-cytotoxicity-of-chitosan-hydrogels-containing-silver-nanoparticles
#9
Bożena Tyliszczak, Anna Drabczyk, Sonia Kudłacik-Kramarczyk, Agnieszka Sobczak-Kupiec
Hydrogels, chitosan as well as silver nanoparticles become in recent years materials characterized by a great interest. In present paper hydrogel based on chitosan and containing mention type of nano-sized particles have been synthesized by means of photopolymerization. Sorption capacity in selected liquids as well as behavior in simulated body fluid (such as Ringer's liquid) have been determined. Particularly attention was paid to the studies on toxicity of the hydrogels in relation to the epidermal cells as well as on their impact on growth of selected strain of bacteria (Escherichia coli)...
June 17, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28625972/prevalence-subtypes-severity-and-determinants-of-ocular-trauma-the-singapore-chinese-eye-study
#10
Mark Yz Wong, Ryan Ek Man, Preeti Gupta, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng, Ecosse Luc Lamoureux
PURPOSE: To describe the prevalence, subtypes, severity and determinants of ocular trauma (OT) in a population-based study in Singapore. METHODS: We included 3353 Chinese adults aged ≥40 years from the Singapore Chinese Eye Study, a population-based study, conducted between 2009 and 2011. OT was defined as self-reported history of any eye injury requiring medical attention with or without hospitalisation, and further classified as blunt object, sharp object or chemical burns related...
June 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28625220/economic-spillovers-from-public-investments-in-medical-countermeasures-a-case-study-of-a-burn-debridement-product
#11
Farah Farahati, Scott Nystrom, David R Howell, Richard Jaffe
OBJECTIVE: The US federal government invests in the development of medical countermeasures for addressing adverse health effects to the civilian population from chemical, biological, and radiological or nuclear threats. We model the potential economic spillover effects in day-to-day burn care for a federal investment in a burn debridement product for responding to an improvised nuclear device. METHODS: We identify and assess 4 primary components for projecting the potential economic spillover benefits of a burn debridement product: (1) market size, (2) clinical effectiveness and cost-effectiveness, (3) product cost, and (4) market adoption rates...
June 19, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28625000/mechanical-restraint-in-an-emergency-department-a-consecutive-series-of-593-cases
#12
Nicolas Beysard, Bertrand Yersin, Pierre-Nicolas Carron
The objective is to describe the characteristics of mechanically restrained patients in the emergency department (ED) of a university hospital and to evaluate the quality of restraint documentation that was filled out according to the dedicated protocol with respect to the law on restraint. All adult patients (≥16 years) who were admitted to the ED from January 2009 to December 2010 and were mechanically restrained were included. We assessed medical and demographic characteristics, the completeness of the dedicated protocol, and the concomitant use of chemical sedation...
June 17, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28623660/the-method-of-coating-fe%C3%A2-o%C3%A2-with-carbon-nanoparticles-to-modify-biological-properties-of-oxide-measured-in-vitro
#13
Tomasz Niemiec, Mariusz Dudek, Natalia Dziekan, Sławomir Jaworski, Aleksandra Przewozik, Emilia Soszka, Anna Koperkiewicz, Piotr Koczoń
The coating of nanoparticles on materials for medical application [e.g., the coating of Fe₃O₄ nanopowder (IONP) with a carbon nanolayer] serves to protect and modify the selected biological, physical, and chemical properties of the coated material. Increases in chemical stability, changes in biocompatibility, and a modified surface structure are examples of the effects caused by the formation of carbon coatings. In the current study, Fe₃O₄ nanoparticles were coated with a carbon nanolayer (IONP@C) in a plasmochemical reactor (using radio-frequency plasma-enhanced chemical vapor deposition methods) under various experimental conditions...
June 16, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28621828/progress-in-the-synthesis-and-biological-evaluation-of-lipid-a-and-its-derivatives
#14
REVIEW
Jian Gao, Zhongwu Guo
Lipid A is one of the core structures of bacterial lipopolysaccharides (LPSs), and it is mainly responsible for the strong immunostimulatory activities of LPS through interactions with the Toll-like receptors and other molecules in the human immune system. To obtain structurally homogeneous and well-defined lipid As and its derivatives in quantities meaningful for various biological studies and applications, their chemical synthesis has become a focal point. This review has provided a survey of significant progresses made in the synthesis of lipid A, and its derivatives that carry diverse saturated and unsaturated lipids, have the phosphate group at its reducing end replaced with a more stable phosphate or carboxyl group, or lack the reducing end phosphate or both phosphate groups, as well as progresses in the synthesis of LPS analogs and other lipid A conjugates...
June 16, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28621412/the-not-so-long-history-of-zebrafish-research-in-israel
#15
Janna Blechman, Gil Levkowitz, Yoav Gothilf
The zebrafish has become a model of choice in fundamental and applied life sciences and is widely used in various fields of biomedical research as a human disease model for cancer, metabolic and neurodegenerative diseases, and regenerative medicine. The transparency of the zebrafish embryo allows real-time visualization of the development and morphogenesis of practically all of its tissues and organs. Zebrafish are amenable to genetic manipulation, for which innovative genetic and molecular techniques are constantly being introduced...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/28619859/criminal-charges-for-child-harm-from-substance-use-in-pregnancy
#16
Cara Angelotta, Paul S Appelbaum
Despite the opposition of medical and public health professionals, several state legislatures are considering laws that permit child abuse charges for substance use during pregnancy. We reviewed legal decisions regarding women charged with a crime against a fetus or child as a result of substance use during pregnancy. We identified 24 judicial opinions published between 1977 and 2015 in cases involving 29 women prosecuted in 19 states. Charges included child endangerment, child abuse, drug delivery, attempted aggravated child abuse, chemical endangerment of a child, child neglect, child mistreatment, homicide, manslaughter, and reckless injury to a child...
June 2017: Journal of the American Academy of Psychiatry and the Law
https://www.readbyqxmd.com/read/28618730/possible-triggering-factors-and-comorbidities-in-newly-diagnosed-autoimmune-bullous-diseases
#17
Sevgi Akarsu, Özlem Özbağçivan, Necla Dolaş, Şebnem Aktan
BACKGROUND/AIM: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. MATERIALS AND METHODS: In this descriptive and prospective study, the demographic data, inhabited regions, smoking and drinking habits, presence of comorbidities, and specific and general potential triggering factors of ABDs considered by the patients were examined...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28618342/monitoring-breast-cancer-treatment-using-a-fourier-transform-infrared-spectroscopy-based-computational-model
#18
J Depciuch, E Kaznowska, S Golowski, A Koziorowska, I Zawlik, M Cholewa, K Szmuc, J Cebulski
Breast cancer affects one in four women, therefore, the search for new diagnostic technologies and therapeutic approaches is of critical importance. This involves the development of diagnostic tools to facilitate the detection of cancer cells, which is useful for assessing the efficacy of cancer therapies. One of the major challenges for chemotherapy is the lack of tools to monitor efficacy during the course of treatment. Vibrational spectroscopy appears to be a promising tool for such a purpose, as it yields Fourier transformation infrared (FTIR) spectra which can be used to provide information on the chemical composition of the tissue...
June 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28618122/purification-of-lignans-from-fructus-arctii-using-off-line-two-dimensional-supercritical-fluid-chromatography-reversed-phase-liquid-chromatography
#19
Bichao Yang, Huaxia Xin, Feier Wang, Jianfeng Cai, Yanfang Liu, Qing Fu, Yu Jin, Xinmiao Liang
As a common traditional Chinese medicine, Fructus Arctii has important clinical medical values. Its main components are lignans, which are difficult to separate and analyze because of the complex composition, similar chemical structures, and close properties. In this study, an off-line two-dimensional supercritical fluid chromatography/reversed-phase liquid chromatography method as well as an effective sample pretreatment method based on hydrophilic interaction chromatography material was developed to enrich the minor lignan fractions and obtain high-purity compounds...
June 15, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28616492/the-role-of-environmental-health-in-one-health-a-uganda-perspective
#20
David Musoke, Rawlance Ndejjo, Edwinah Atusingwize, Abdullah Ali Halage
BACKGROUND: One Health is the integrative effort of multiple disciplines working locally, nationally and globally to attain optimal health for people, animals and the environment. As the human population continues to increase across the world, the interface of people, animals and the environment becomes more significant and impactful. For the past few years, the One Health concept has brought together experts in the areas of animal and human health. It has provided a new synthesis for public health and veterinary communities across the world...
December 2016: One Health
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