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https://www.readbyqxmd.com/read/29048378/analysis-of-non-volatile-chemical-constituents-of-menthae-haplocalycis-herba-by-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry
#1
Lu-Lu Xu, Jing-Jing Xu, Kun-Rui Zhong, Zhan-Peng Shang, Fei Wang, Ru-Feng Wang, Le Zhang, Jia-Yu Zhang, Bin Liu
Menthae Haplocalycis herba, one kind of Chinese edible herbs, has been widely utilized for the clinical use in China for thousands of years. Over the last decades, studies on chemical constituents of Menthae Haplocalycis herba have been widely performed. However, less attention has been paid to non-volatile components which are also responsible for its medical efficacy than the volatile constituents. Therefore, a rapid and sensitive method was developed for the comprehensive identification of the non-volatile constituents in Menthae Haplocalycis herba using ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap)...
October 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29047370/the-recent-development-and-applications-of-fluidic-channels-by-3d-printing
#2
REVIEW
Yufeng Zhou
The technology of "Lab-on-a-Chip" allows the synthesis and analysis of chemicals and biological substance within a portable or handheld device. The 3D printed structures enable precise control of various geometries. The combination of these two technologies in recent years makes a significant progress. The current approaches of 3D printing, such as stereolithography, polyjet, and fused deposition modeling, are introduced. Their manufacture specifications, such as surface roughness, resolution, replication fidelity, cost, and fabrication time, are compared with each other...
October 18, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29046809/hospital-resuscitation-teams-a-review-of-the-risks-to-the-healthcare-worker
#3
REVIEW
Stephen M Vindigni, Juan N Lessing, David J Carlbom
BACKGROUND: "Code blue" events and related resuscitation efforts involve multidisciplinary bedside teams that implement specialized interventions aimed at patient revival. Activities include performing effective chest compressions, assessing and restoring a perfusing cardiac rhythm, stabilizing the airway, and treating the underlying cause of the arrest. While the existing critical care literature has appropriately focused on the patient, there has been a dearth of information discussing the various stresses to the healthcare team...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/29046671/generation-of-persister-cells-of-pseudomonas-aeruginosa-and-staphylococcus-aureus-by-chemical-treatment-and-evaluation-of-their-susceptibility-to-membrane-targeting-agents
#4
Lucia Grassi, Mariagrazia Di Luca, Giuseppantonio Maisetta, Andrea C Rinaldi, Semih Esin, Andrej Trampuz, Giovanna Batoni
Persister cells (PCs) are a subset of dormant, phenotypic variants of regular bacteria, highly tolerant to antibiotics. Generation of PCs in vivo may account for the recalcitrance of most chronic infections to antimicrobial treatment and demands for the identification of new antimicrobial agents able to target such cells. The present study explored the possibility to obtain in vitro PCs of Pseudomonas aeruginosa and Staphylococcus aureus at high efficiency through chemical treatment, and to test their susceptibility to structurally different antimicrobial peptides (AMPs) and two clinically used peptide-based antibiotics, colistin and daptomycin...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29046493/sp-current-global-standards-for-chemical-protective-clothing-how-to-choose-the-right-protection-for-the-right-job
#5
Eric VAN Wely
The first standards for chemical protective clothing (CPC) emerged mid to late 1980's and have evolved since as most standards are revisited every 5 years. Over the past years, we have also seen a strengthening of the chemical and worker protection legislation around the globe (various forms of REACH) but also protection of workers. The most prevalent standards originate under the auspices of the International Standards Organisation (ISO), European Committee for Standardisation (CEN) or under various US standards organisations (e...
October 17, 2017: Industrial Health
https://www.readbyqxmd.com/read/29044983/horseradish-peroxidase-catalyzed-hydrogelation-for-biomedical-biopharmaceutical-and-biofabrication-applications
#6
Shinji Sakai, Masaki Nakahata
Horseradish peroxidase (HRP)-catalyzed hydrogelation has attracted much attention due to the ease of handling, high biocompatibility, and processability. This review summarizes recent developments including cutting-edge research using HRP-mediated hydrogelation toward biomedical, biopharmaceutical, and biofabrication applications. From the viewpoint of polymer chemistry, the basic chemistry behind hydrogelation, the structure-property relationship, and hybridization of multiple materials using HRP-catalyzed hydrogelation are summarized...
October 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29044934/aqueous-gold-overgrowth-of-silver-nanoparticles-merging-the-plasmonic-properties-of-silver-with-the-functionality-of-gold
#7
Martin Mayer, Anja Maria Steiner, Falk Röder, Petr Formanek, Tobias König, Andreas Fery
To date, it has not been possible to combine the high optical quality of silver particles with good chemical stability and synthetic convenience in a fully aqueous system, while simultaneously allowing chemical surface functionalization. We present a synthetic pathway for future developments in information, energy and medical technology where strong optical/electronic properties are crucial. Therefore, the advantages inherent to gold are fused with the plasmonic properties of silver in a fully aqueous Au/Ag/Au core-shell-shell system...
October 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29042654/electrocatalytic-performance-of-chemically-synthesized-pin-au-sgo-composite-toward-mediated-biofuel-cell-anode
#8
Ruma Perveen, Inamuddin, Sufia Ul Haque, Abu Nasar, Abdullah M Asiri, Ghulam Md Ashraf
The proposed work intended to make an intellectual contribution to the domain of green nanotechnology which emphasizes the chemical synthesis of a conducting nanocomposite based on the incorporation of gold nanoparticles (Au) into the redox matrix of polyindole (PIn) along with the subsequent improvement in the overall properties of the composite by the addition of sulfonated graphene oxide (SGO). The bioanode was developed by the deposition of the PIn-Au-SGO nanocomposite with subsequent immobilization of ferritin (Frt) and glucose oxidase (GOx) on the glassy carbon electrode (GC)...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040490/proceedings-from-an-international-conference-on-ablation-therapy-for-barrett-s-mucosa-brittany-france-31-august-2-september-1997
#9
C G Bremner, T R Demeester
The increasing incidence of adenocarcinoma of the lower esophagus and cardia arising in Barrett's metaplastic epithelium continues to be of great concern because medical and surgical efforts to reverse the process have been disappointing. A potential answer to the problem is removal of the metaplastic epithelium. Modern technology has introduced physical and chemical modalities which facilitate ablation of the neo-epithelium endoscopically. These techniques have been used in several centers, and preliminary results are encouraging...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29039228/evaluation-of-the-respiratory-tract-toxicity-of-ortho-phthalaldehyde-a-proposed-alternative-for-the-chemical-disinfectant-glutaraldehyde
#10
Natasha R Catlin, Cynthia J Willson, Matthew Stout, Grace E Kissling, Suramya Waidyanatha, Gregory L Baker, Barry K Hayden, Michael Wyde
ortho-Phthalaldehyde (OPA) is a high-level chemical disinfectant that is commonly used for chemical sterilization of dental and medical instruments as an alternative to glutaraldehyde, a known skin and respiratory sensitizer. Concern for safe levels of human exposure remains due to a lack of toxicity data as well as human case reports of skin and respiratory sensitization following OPA exposure. The present study evaluated the inhalational toxicity of OPA in Harlan Sprague-Dawley rats and B6C3F1/N mice. Groups of 10 male and female rats and mice were exposed to OPA by whole-body inhalation for 3 months at concentrations of 0 (control), 0...
October 17, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29038905/recent-advances-in-production-of-5-aminolevulinic-acid-using-biological-strategies
#11
REVIEW
Zhen Kang, Wenwen Ding, Xu Gong, Qingtao Liu, Guocheng Du, Jian Chen
5-Aminolevulinic acid (5-ALA) is the precursor for the biosynthesis of tetrapyrrole compounds and has broad applications in the medical and agricultural fields. Because of the disadvantages of chemical synthesis methods, microbial production of 5-ALA has drawn intensive attention and has been regarded as an alternative in the last years, especially with the rapid development of metabolic engineering and synthetic biology. In this mini-review, recent advances on the application and microbial production of 5-ALA using novel biological approaches (such as whole-cell enzymatic-transformation, metabolic pathway engineering and cell-free process) are described and discussed in detail...
October 16, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29037046/admet-evaluation-in-drug-discovery-18-reliable-prediction-of-chemical-induced-urinary-tract-toxicity-by-boosting-machine-learning-approaches
#12
Tailong Lei, Huiyong Sun, Yu Kang, Feng Zhu, Hui Liu, Wenfang Zhou, Zhe Wang, Dan Li, Youyong Li, Tingjun Hou
Xenobiotic chemicals and their metabolites are mainly excreted out of our bodies by the The urinary tract is the main organ excreting xenobiotic chemicals and their metabolites through the urine. Chemical-induced urinary tract toxicity is one of the main reasons that cause failure during drug development, and it is a common adverse event for medications, natural supplements and environmental chemicals. Despites its importance, there are only a few in silico models for assessing urinary tract toxicity for a large number of compounds with diverse chemical structures...
October 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29033605/onabotulinum-toxin-a-in-the-treatment-of-chronic-migraine-patient-selection-and-special-considerations
#13
REVIEW
Piero Barbanti, Patrizia Ferroni
Discovered by serendipity, onabotulinum toxin A (BoNT-A) is the only US Food and Drug Administration-approved treatment for the prevention of chronic migraine (CM), one of the most disabling and burdensome human conditions. Its efficacy, safety and tolerability, proved by the largest and longest migraine therapeutic trial (the Phase III Research Evaluating Migraine Prophylaxis Therapy program [PREEMPT]), have been replicated by various real-life studies also in the presence of medication overuse. The benefit of BoNT-A prophylaxis is likely due to its ability to counteract peripheral and central nociceptive sensitization through reversible chemical denervation of pericranial sensitive afferents...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29030227/exploring-the-feasibility-of-obtaining-mifepristone-and-misoprostol-from-the-internet
#14
Chloe Murtagh, Elisa Wells, Elizabeth G Raymond, Francine Coeytaux, Beverly Winikoff
OBJECTIVES: We aimed to document the experience of buying abortion pills from online vendors that do not require a prescription and to evaluate the active ingredient content of the pills received. STUDY DESIGN: We searched the internet to identify a convenience sample of websites that sold mifepristone and misoprostol to purchasers in the United States and attempted to order these products. We documented price, shipping time and other aspects of ordering. We sent the samples received to a testing laboratory that measured the amount of active ingredient in individual tablets...
October 10, 2017: Contraception
https://www.readbyqxmd.com/read/29030166/mdpv-and-%C3%AE-pvp-use-in-humans-the-twisted-sisters
#15
REVIEW
Laurent Karila, Geneviève Lafaye, Amandine Scocard, Olivier Cottencin, Amine Benyamina
The new psychoactive substances phenomenon continues to represent a considerable public health challenge. Synthetic cathinones are β-keto amphetamine analogues, also known as legal highs, research chemicals, bath salts. These drugs have surfaced as a popular alternative to other illicit drugs of abuse, such as cocaine, MDMA, and methamphetamine, due to their potent psychostimulant and empathogenic effects. Pyrovalerone cathinones (a-pyrrolidinophenones) form a distinct group of designer cathinones, such as MDPV...
October 10, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29028587/chemical-constituents-and-medical-benefits-of-plantago-major
#16
REVIEW
Muhammad Bahrain Adom, Muhammad Taher, Muhammad Fathiy Mutalabisin, Mohamad Shahreen Amri, Muhammad Badri Abdul Kudos, Mohd Wan Azizi Wan Sulaiman, Pinaki Sengupta, Deny Susanti
The medicinal benefits of Plantago major have been acknowledged around the world for hundreds of years. This plant contains a number of effective chemical constituents including flavonoids, alkaloids, terpenoids, phenolic acid derivatives, iridoid glycosides, fatty acids, polysaccharides and vitamins which contribute to its exerting specific therapeutic effects. Correspondingly, studies have found that Plantago major is effective as a wound healer, as well as an antiulcerative, antidiabetic, antidiarrhoeal, anti-inflammatory, antinociceptive, antibacterial, and antiviral agent...
October 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29028361/new-findings-on-biological-actions-and-clinical-applications-of-royal-jelly-a-review
#17
Mozafar Khazaei, Atefe Ansarian, Elham Ghanbari
Royal jelly (RJ) is a natural bee product with great potential for use in medicine. The chemical composition of RJ indicates the presence of various bioactive substances including 10-hydroxydecanoic acid and 24-methylenecholesterol. In addition, a number of biological and pharmacological activities of RJ have been documented. The aim of this study was to review the biological and medical effects of RJ. The search was conducted in articles from electronic and scientific literature databases such as Pub Med, Science Direct, Scopus, Medline, and ISI Web of Science published from 1990 to 2017 using keywords of pharmacological, biological, and clinical effects and royal jelly...
October 13, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29026646/binary-titanium-alloys-as-dental-implant-materials-a-review
#18
REVIEW
Xiaotian Liu, Shuyang Chen, James K H Tsoi, Jukka Pekka Matinlinna
Titanium (Ti) has been used for long in dentistry and medicine for implant purpose. During the years, not only the commercially pure Ti but also some alloys such as binary and tertiary Ti alloys were used. The aim of this review is to describe and compare the current literature on binary Ti alloys, including Ti-Zr, Ti-In, Ti-Ag, Ti-Cu, Ti-Au, Ti-Pd, Ti-Nb, Ti-Mn, Ti-Mo, Ti-Cr, Ti-Co, Ti-Sn, Ti-Ge and Ti-Ga, in particular to mechanical, chemical and biological parameters related to implant application. Literature was searched using the PubMed and Web of Science databases, as well as google without limiting the year, but with principle key terms such as ' Ti alloy', 'binary Ti ', 'Ti-X' (with X is the alloy element), 'dental implant' and 'medical implant'...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29023994/biosensors-classifications-medical-applications-and-future-prospective
#19
REVIEW
Hani A Alhadrami
Biosensors are devices that combine a biological material with a suitable platform for detection of pathogenic organisms, carcinogenic, mutagenic and/or toxic chemicals or for reporting a biological effect. In recent years, enormous number of different types of biosensors have been constructed and developed for several medical applications. The reason for that was primarily due to the numerous advantages and applications that can be offered by biosensors. This review article has been started with demonstrating the powerful of biosensor technologies versus analytical and conventional techniques...
October 10, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29023562/efficacy-of-chemical-disinfectants-for-the-containment-of-the-salamander-chytrid-fungus-batrachochytrium-salamandrivorans
#20
Pascale Van Rooij, Frank Pasmans, Yanaika Coen, An Martel
The recently emerged chytrid fungus Batrachochytrium salamandrivorans (Bsal) causes European salamander declines. Proper hygiene protocols including disinfection procedures are crucial to prevent disease transmission. Here, the efficacy of chemical disinfectants in killing Bsal was evaluated. At all tested conditions, Biocidal®, Chloramine-T®, Dettol medical®, Disolol®, ethanol, F10®, Hibiscrub®, potassium permanganate, Safe4®, sodium hypochlorite, and Virkon S®, were effective at killing Bsal. Concentrations of 5% sodium chloride or lower, 0...
2017: PloS One
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