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https://www.readbyqxmd.com/read/29453547/using-of-quantum-dots-in-biology-and-medicine
#1
Svetlana Pleskova, Elza Mikheeva, Ekaterina Gornostaeva
Quantum dots are nanoparticles, which due to their unique physical and chemical (first of all optical) properties, are promising in biology and medicine. There are many ways for quantum dots synthesis, both in the form of nanoislands self-forming on the surfaces, which can be used as single-photon emitters in electronics for storing information, and in the form of colloidal quantum dots for diagnostic and therapeutic purposes in living systems. The paper describes the main methods of quantum dots synthesis and summarizes medical and biological ways of their use...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29448626/scaffolds-based-on-collagen-hyaluronan-and-sericin-with-potential-applications-as-controlled-drug-delivery-system
#2
Raluca Vulpe, Marcel Popa, Luc Picton, Catalina A Peptu, Nita Tudorachi, Liliana Verestiuc
Natural proteins have been extensively studied as matrices for tissue engineering, due to their excellent biocompatibility and biological properties associated with increasing cell proliferation. By generating complex materials, cell and tissue functions can be tailored to obtain a specific direction, according to the medical needs. The aim of this paper was to obtain scaffolds based on collagen, hyaluronan and sericin, with morphology and physical-chemical properties adequate for controlled drug delivery systems...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448502/-in-vitro-mechanical-performance-study-of-biodegradable-polylactic-acid-hydroxyapatite-nanocomposites-for-fixation-medical-devices
#3
Jinsu Park, Bae-Jung Kim, Ji-Yeong Hwang, Yo-Woong Yoon, Hoon-Sang Cho, Dong-Hyun Kim, Jong Kook Lee, Seog-Young Yoon
Osteoconductive, biocompatible, and resorbable organic/inorganic composites are most commonly used in fixation medical devices, such as suture anchors and interference screws, because of their unique physical and chemical properties. Generally, studies on biodegradable composites have focused on their mechanical properties based on the composition and the individual roles of organic and inorganic biomaterials. In this study, we prepared biodegradable organic/inorganic nanocomposite materials using the solvent mixing process and conventional molding...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29446772/production-of-ready-to-use-few-layer-graphene-in-aqueous-suspensions
#4
Jose M González-Domínguez, Verónica León, María Isabel Lucío, Maurizio Prato, Ester Vázquez
Graphene has promising physical and chemical properties such as high strength and flexibility, coupled with high electrical and thermal conductivities. It is therefore being incorporated into polymer-based composites for use in electronics and photonics applications. A main constraint related to the graphene development is that, being of a strongly hydrophobic nature, almost all dispersions (usually required for its handling and processing toward the desired application) are prepared in poisonous organic solvents such as N-methyl pyrrolidone or N,N-dimethyl formamide...
March 2018: Nature Protocols
https://www.readbyqxmd.com/read/29445628/medicinal-properties-of-adiantum-capillus-veneris-linn-in-traditional-medicine-and-modern-phytotherapy-a-review-article
#5
REVIEW
Sahar Dehdari, Homa Hajimehdipoor
Background: Adiantum capillus-veneris Linn (Maidenhair fern) is an herb belonging to the family Pteridaceae. It is named as " Pare-siavashan " in medical and pharmaceutical textbooks of Iranian Traditional Medicine. The fronds of Maidenhair fern were mainly administrated by ancient physicians as single medicine or in combination with other plants in multi-herbal formulations for curing different diseases. Because of different chemical compositions, the herb fronds were also assessed for its numerous pharmacological effects...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29445375/the-role-of-cytochromes-p450-in-infection
#6
REVIEW
Elisavet Stavropoulou, Gratiela G Pircalabioru, Eugenia Bezirtzoglou
Cytochromes are expressed in many different tissues of the human body. They are found mostly in intestinal and hepatic tissues. Cytochromes P450 (CYPs) are enzymes that oxidize substances using iron and are able to metabolize a large variety of xenobiotic substances. CYP enzymes are linked to a wide array of reactions including and O-dealkylation, S-oxidation, epoxidation, and hydroxylation. The activity of the typical P450 cytochrome is influenced by a variety of factors, such as genus, environment, disease state, herbicide, alcohol, and herbal medications...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29444566/chemical-characterization-of-novel-natural-products-from-the-roots-of-asian-rice-oryza-sativa-that-control-adipocyte-and-osteoblast-differentiation
#7
Hee Rae Kang, Hyung Sik Yun, Tae Kyoung Lee, Seulah Lee, Seon-Hee Kim, Eunjung Moon, Ki-Moon Park, Ki Hyun Kim
Oryza sativa L. is consumed globally as a staple food and its roots have been used as a Korean and Chinese medical supplement for protection of the stomach and lungs and for amelioration of vomiting and fever. In our continuing search for biologically effective metabolites from Korean natural materials, we found that an EtOH extract of O. sativa root reciprocally regulated adipocyte and osteoblast differentiation. Chemical analysis of the EtOH extract using a bioassay-guided fractionation protocol led to the isolation and determination of two novel lignans, oryzativols A and B, responsible for these regulatory activities...
February 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29443789/polymorphisms-of-drug-metabolizing-enzyme-cyp2e1-in-chinese-uygur-population
#8
Linhao Zhu, Yongjun He, Fanglin Niu, Mengdan Yan, Jing Li, Dongya Yuan, Tianbo Jin
Pharmacogenetics is the genetic basis of pharmacokinetics, genetic testing, and clinical management in diseases. Evaluation about genetic alterations of drug metabolizing enzymes in human genome contributes toward understanding the interindividual and interethnic variability for clinical response to potential toxicants. CYP2E1 gene encodes a drug-metabolizing enzyme that metabolizes mostly small, polar molecules, including toxic laboratory chemicals. The aim of this study was to investigate CYP2E1 polymorphisms and gene profile in a Chinese Uygur population...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443502/direct-classification-of-gc-%C3%A3-gc-analyzed-complex-mixtures-using-non-negative-matrix-factorization-based-feature-extraction
#9
Yasuyuki Zushi, Shunji Hashimoto
Complex chemical mixtures need to be evaluated to, for example, aid in medical diagnoses, assess product quality, and assess environmental conditions. Two-dimensional gas chromatography (GC × GC), which is a comprehensive analytical technique, combined with data classification techniques has attracted great interest for assessing mixtures. In this study, a nontarget cross-sample analysis-based unsupervised direct classification method using non-negative matrix factorization was developed for assessing mixtures analyzed by GC × GC...
February 14, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29442923/polycarbonate-nanofluidic-chip-fabrication-technique-by-hot-embossing-and-thermal-bonding
#10
Zhifu Yin, Helin Zou, Lei Sun
Nanofluidic devices are becoming increasingly critical for medical, chemical and biological applications. In this paper, a 2D Polycarbonate (PC) nanofluidic chip was fabricated by hot embossing and thermal bonding method. In this paper, the effect of the hot embossing parameters on the replication precision of 2D PC nanochannels was investigated by finite element method. To increase the bonding rate of the chip, the parameters of the thermal bonding process were optimized. Under the optimized parameters the 2D PC nanofluidic chip was successfully fabricated...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442668/cellulose-whiskers-influence-the-morphology-and-antibacterial-properties-of-silver-nanoparticles-composites
#11
Kelcilene B R Teodoro, Rafaela C Sanfelice, Luiz H C Mattoso, Daniel S Correa
Cellulose, the main component of plant cell walls, is a biopolymer widely used for industrial applications, including, food, paper and textile fabrication. More recently, hybrid materials composed of cellulose nanostructures and metal nanoparticles have been applied in diverse areas such as medical and pharmaceutical applications. In this work, cellulose-silver nanoparticles (AgNPs) hybrid material was synthesized and the influence of cellulose, employed as a stabilizer agent, was investigated. Specifically, cellulose whiskers (CCW) were extracted from commercial cotton fibers by acid hydrolysis route, while the AgNPs were synthesized by reducing silver salt using sodium citrate and/or sodium borohydride in the presence of CCW...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442495/flexible-disposable-cellulose-paper-based-mos2-cu2s-hybrid-for-wireless-environmental-monitoring-and-multifunctional-sensing-of-chemical-stimuli
#12
Parikshit Sahatiya, Anand Kadu, Harshit Gupta, P Thanga Gomathi, Sushmee Badhulika
Multifunctional sensors responding to different chemical stimuli fabricated using functional nanomaterials still remains a challenge due to the usage of same sensor multiple times for different sensing and unreliable frontend processing of the sensing data. This challenge is intensified by the lack of suitable techniques for fabricating disposable sensors which are integrated to smartphone with a dedicated application developed for each sensing. A novel MoS2/Cu2S hybrid grown on disposable cellulose paper by hydrothermal method is reported for its utilization in humidity, temperature and breath sensing and ethanol adulteration wherein the data can be wirelessly transmitted to smartphone with dedicated application module for each sensing...
February 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29440898/nanosilver-new-ageless-and-versatile-biomedical-therapeutic-scaffold
#13
REVIEW
Shahid Ullah Khan, Tawfik A Saleh, Abdul Wahab, Muhammad Hafeez Ullah Khan, Dilfaraz Khan, Wasim Ullah Khan, Abdur Rahim, Sajid Kamal, Farman Ullah Khan, Shah Fahad
Silver nanotechnology has received tremendous attention in recent years, owing to its wide range of applications in various fields and its intrinsic therapeutic properties. In this review, an attempt is made to critically evaluate the chemical, physical, and biological synthesis of silver nanoparticles (AgNPs) as well as their efficacy in the field of theranostics including microbiology and parasitology. Moreover, an outlook is also provided regarding the performance of AgNPs against different biological systems such as bacteria, fungi, viruses, and parasites (leishmanial and malarial parasites) in curing certain fatal human diseases, with a special focus on cancer...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29438752/design-and-evaluation-of-chitosan-poly-l-lactide-pectin-based-composite-scaffolds-for-cartilage-tissue-regeneration
#14
Sarada Prasanna Mallick, Bhisham Narayan Singh, Amit Rastogi, Pradeep Srivastava
Poor regenerative potential of cartilage tissue due to the avascular nature and lack of supplementation of reparative cells impose an important challenge in recent medical practice towards development of artificial extracellular matrix with enhanced neo-cartilage tissue regeneration potential. Chitosan (CH), poly (l-lactide) (PLLA), and pectin (PC) compositions were tailored to generate polyelectrolyte complex based porous scaffolds using freeze drying method and crosslinked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), N-hydroxysuccinimide (NHS) solution containing chondroitin sulfate (CS) to mimic the composition as well as architecture of the cartilage extracellular matrix (ECM)...
February 10, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29438733/pre-validation-of-an-in-vitro-skin-irritation-test-for-medical-devices-using-the-reconstructed-human-tissue-model-epiderm%C3%A2
#15
Helena Kandarova, Jamin A Willoughby, Wim H De Jong, Silvia Letasiova, Tatiana Milasova, Michael A Bachelor, Bridget Breyfogle, Yuki Handa, Liset De la Fonteyne, Kelly P Coleman
Assessment of dermal irritation is an essential component of the safety evaluation of medical devices. Reconstructed human epidermis (RhE) models have replaced rabbit skin irritation testing for neat chemicals and their mixtures (OECD Test Guideline 439). However, this guideline cannot be directly applied to the area of medical devices (MD) since their non-toxicity assessment is largely based on the testing of MD extracts that may have very low irritation potential. Therefore, the RhE-methods previously validated with neat chemicals needed to be modified to reflect the needs for detection of low levels of potential irritants...
February 10, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29437230/lectin-isolated-from-japanese-red-sword-beans-canavalia-gladiata-as-a-potential-cancer-chemopreventive-agent
#16
Satsuki Une, Koji Nonaka, Junich Akiyama
In this study, we investigated the chemical and biological profile of lectin isolated from Japanese red sword beans (Canavalia gladiata; RSBs). RSB lectin was purified using maltamyl-Sepharose 4B and subjected to amino acid composition and partial amino acid sequencing analyses, and evaluated for blood and carbohydrate specificity, mitogenic activity, splenic natural killer (NK) cell activity, and its effect on B16 melanoma cell proliferation, compared with Concanavalin A (Con A). The amino acid composition and sequences of RSB lectin were similar to those of Con A...
February 13, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29436817/protective-layer-development-for-enhancing-stability-and-drug-delivery-capabilities-of-des-surface-crystallized-coatings
#17
Shady Farah
Carrier-free drug eluting stents (DES) based crystalline coatings are gaining prominence due to their function, skipping many limitations and clinical complications of the currently marketed DES. However, their usage has been humbled by crystalline coating inflexibility, limited mechanical and physical properties. This study reports for the first time a protective top coating development for enhancing crystalline coating merits and delivery capabilities. Flexible and water soluble polysaccharide top coating was developed and applied onto Rapamycin (RM) crystalline carpet...
February 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29436217/a-stealth-and-fully-laden-drug-carrier-self-assembled-nanogel-encapsulated-with-epigallocatechin-gallate-and-sirna-for-drug-resistant-breast-cancer-therapy
#18
Jie Ding, Tingxizi Liang, Qianhao Min, Li-Ping Jiang, Jun-Jie Zhu
For co-delivery of therapeutic genes and chemical agents in combined therapy, the ideal drug delivery system (DDS) entails high-capacity and low-body toxicity carriers, allowing adequate drug dose for tumor region while yielding low residue in normal tissue. To augment the gene/drug load capacity and circumvent the potential toxicity brought by traditional inorganic and polymeric nanocarriers, a "stealth" carrier was herein designed in a simple self-assembly of (-)-epigallocatechin-3-O-gallate (EGCG) and small interfering RNA (siRNA) by recruiting protamine as biodegradable medium for the treatment of drug-resistant triple-negative breast cancer (TNBC)...
February 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29430209/the-effect-of-soil-on-human-health-an-overview
#19
J J Steffan, E C Brevik, L C Burgess, A Cerdà
Soil has a considerable effect on human health, whether those effects are positive or negative, direct or indirect. Soil is an important source of nutrients in our food supply and medicines such as antibiotics. However, nutrient imbalances and the presence of human pathogens in the soil biological community can cause negative effects on health. There are also many locations where various elements or chemical compounds are found in soil at toxic levels, because of either natural conditions or anthropogenic activities...
January 2018: European Journal of Soil Science
https://www.readbyqxmd.com/read/29428807/the-imprint-of-salivary-secretion-in-autoimmune-disorders-and-related-pathological-conditions
#20
REVIEW
Kashi Raj Bhattarai, Raghupatil Junjappa, Mallikarjun Handigund, Hyung-Ryong Kim, Han-Jung Chae
Xerostomia is a state of oral dryness associated with salivary gland dysfunction and is induced by stress, radiation and chemical therapy, various systemic and autoimmune diseases, and specific medications. Fluid secretion is interrupted by the stimulation of neurotransmitter-induced increase in cytosolic calcium ([Ca 2+ ] i ) in salivary gland acinar cells, prompting the mobilization of ion channels and their transporters. Salivary fluid and protein secretion are principally dependent on parasympathetic and sympathetic nerves...
February 8, 2018: Autoimmunity Reviews
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