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https://www.readbyqxmd.com/read/29673452/-modified-cheng-s-juanbi-decoction-reduces-camp-level-of-t-lymphocytes-in-peripheral-blood-and-cd4-cd8-t-cell-ratio-among-rats-with-adjuvant-arthritis
#1
Xia Xu, Huan DU, Yalan Wu, Hui Cheng, Jian Cao, Qingwei Meng, Mengyuan Guo
Objective To investigate the effects of modified Cheng's Juanbi Decoction (CJBD) on the level of cAMP in T lymphocytes and CD4+ /CD8+ T cell ratio among rats with adjuvant arthritis (AA). Methods Male adult SD rats were randomly divided into normal control group, AA group, CJBD group, and tripterygium glycosides tablet (TGT) group. Blowing/cold water and Freund's complete adjuvant were used to establish a rat model of AA with wind-cold-dampness arthralgia. The control group was given normal saline by gavage, and the CJBD group and TGT group were given respective therapies...
February 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29669532/pulmonary-lymphangioleimyomatosis-and-systemic-lupus-erythematosus-in-a-menopausal-woman
#2
Hong Hong, Ruiheng Yang, Xiuzhen Li, Mengjun Wang, Zhongchao Ma
BACKGROUND: Pulmonary lymphangioleimyomatosis (PLAM) is a rare disease involving lung. PLAM primarily affects young women, a characteristic it shares with systemic lupus erythematosus (SLE). Estrogen has long been assumed to play an important role both in PLAM and SLE. We report a menopausal woman, who was found to have PLAM 1 year after she was diagnosed with SLE. Her chest radiograph was normal in the early phase of SLE. CASE PRESENTATION: A 52-year-old Chinese woman was referred to our hospital in August 2014 because of swelling in both legs...
April 18, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29668626/effect-of-arthrocentesis-plus-platelet-rich-plasma-and-platelet-rich-plasma-alone-in-the-treatment-of-temporomandibular-joint-osteoarthritis-a-retrospective-matched-cohort-study-a-strobe-compliant-article
#3
Shang-Lun Lin, Chiang-Chin Tsai, Shang-Liang Wu, Shun-Yao Ko, Wei-Fan Chiang, Jung Wu Yang
Although the research on using platelet-rich plasma (PRP) for temporomandibular joint osteoarthritis (TMJ-OA) has advanced, no unified standards exist for determining the joint use of arthrocentesis and the injection dose and frequency of PRP. This study aimed to compare the efficacy of 2 TMJ-OA treatment approaches, arthrocentesis plus platelet-rich plasma (A+PRP) and PRP alone, and attempted to provide another potential treatment option with a single injection of 2 mL of high-concentration and high-purity PRP...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29666738/combined-diagnosis-of-systemic-lupus-erythematosus-and-tuberculosis-in-an-irish-adolescent-female
#4
Kene Ebuka Maduemem, Comfort O Adedokun, Adela Vatca
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown aetiology, which can affect any organ system. Tuberculosis (TB) is a common infection in SLE because of immune dysregulation associated with the latter. We report a case of an adolescent female who presented with a year's history of polyarticular arthralgia and fever. Physical examination revealed a large left effusion that needed drainage. Investigations revealed a combined diagnosis of SLE and TB. Management comprised quadruple anti-TB therapy and SLE treatment...
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29665800/mda-5-associated-rapidly-progressive-interstitial-lung-disease-with-recurrent-pneumothoraces-a-case-report
#5
Safi Alqatari, Peter Riddell, Sinead Harney, Michael Henry, Grainne Murphy
BACKGROUND: Clinically hypomyopathic dermatomyositis is a rare disease that is important to recognize, investigate and treat early as it is associated with poor prognosis. In a proportion of patients, myositis specific antibodies could be negative, but with high clinical suspicion, myositis associated antibodies should be ordered. Anti-MDA-5 antibodies was reported in literature to be associated with severe and rapidly progressive interstitial lung disease, with few case reports of pneumothorax and/or pneumomediastinum...
April 17, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29664511/bullous-henoch-sch%C3%A3-nlein-purpura-case-report
#6
Trinidad Hasbún, Ximena Chaparro, Viera Kaplan, Felipe Cavagnaro, Alex Castro
Henoch-Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia, abdominal pain and renal disease. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. Objec tive: To report an unusual cutaneous manifestation of HSP in children. CASE REPORT: A 14-year-old girl complained about a 2-week painful bullous rash in both lower extremities and multiple arthral gias...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29664389/cerebrospinal-fluid-immunoglobulins-as-potential-biomarkers-of-chikungunya-encephalitis
#7
Marzia Puccioni-Sohler, Luiz Claudio Farias, Mauro Jorge Cabral-Castro, Mariano G Zalis, Rosangela S Kalil, Maria Cecília F Salgado
Chikungunya virus causes fever and severe polyarthritis or arthralgia and is associated with neurologic manifestations that are sometimes challenging to diagnose. We demonstrate intrathecal synthesis of chikungunya antibodies in a patient with a history of acute infection complicated by encephalitis. The specificity of the intracerebral immune response supports early chikungunya-associated encephalitis diagnosis.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29664375/surveillance-for-mosquitoborne-transmission-of-zika-virus-new-york-city-ny-usa-2016
#8
Amanda Wahnich, Sandhya Clark, Danielle Bloch, Hannah Kubinson, Gili Hrusa, Dakai Liu, Jennifer L Rakeman, Bisram Deocharan, Lucretia Jones, Sally Slavinski, Alaina Stoute, Robert Mathes, Don Weiss, Erin E Conners
A large number of imported cases of Zika virus infection and the potential for transmission by Aedes albopictus mosquitoes prompted the New York City Department of Health and Mental Hygiene to conduct sentinel, enhanced passive, and syndromic surveillance for locally acquired mosquitoborne Zika virus infections in New York City, NY, USA, during June-October 2016. Suspected case-patients were those >5 years of age without a travel history or sexual exposure who had >3 compatible signs/symptoms (arthralgia, fever, conjunctivitis, or rash)...
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29660262/reactive-periostitis-from-inhalant-abuse
#9
Lauren E Hock, Iiro Honkanen, Wendy Fiordellisi, Brittany Bettendorf
The patient, a 36-year-old woman, presented with a 6-week history of swollen hands and fingers and associated arthralgia. She had a history of polysubstance abuse. The arthralgia and swelling started one month after she began inhaling two cans of "Dust-Off" (1,1-difluoroethane) daily. Physical examination revealed tender proximal and middle phalanges of all fingers bilaterally with bulbous appearance (A). There was no clubbing. Radiography of the hands revealed diffuse reactive periostitis with discrete layering of periosteal bone formation without bony destruction (B)...
April 16, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29643634/tanezumab-therapy-targeting-nerve-growth-factor-in-pain-pathogenesis
#10
Mona K Patel, Alan D Kaye, Richard D Urman
In recent years, nerve growth factor (NGF) and the NGF receptor have become potential therapeutic targets in the treatment of acute and chronic pain states. NGF is a neurotrophin involved in regulating the function of sensory and sympathetic neurons during development. Numerous pain states have been linked to elevated levels of NGF and its role in increasing the perception of pain. Tanezumab, a recombinant humanized monoclonal antibody (IgG), was developed to target NGF, binding both circulating and local tissue NGF preventing interaction with the tropomyosin-related kinase-A and p75 receptors...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29628378/pegvaliase-for-the-treatment-of-phenylketonuria-a-pivotal-double-blind-randomized-discontinuation-phase-3-clinical-trial
#11
Cary O Harding, R Stephen Amato, Mary Stuy, Nicola Longo, Barbara K Burton, John Posner, Haoling H Weng, Markus Merilainen, Zhonghua Gu, Joy Jiang, Jerry Vockley
INTRODUCTION: Pegvaliase is a recombinant Anabaena variabilis phenylalanine ammonia lyase (PAL) enzyme under investigation for treatment of adult phenylketonuria (PKU). This manuscript describes results of a randomized discontinuation trial (RDT) designed to evaluate the effects of pegvaliase treatment on blood phenylalanine (Phe) and neuropsychiatric outcomes in adults with PKU. METHODS: PRISM-2 is a 4-part, Phase 3 study that enrolled adults with PKU receiving pegvaliase treatment (initiated in a prior Phase 2 or Phase 3 study)...
March 18, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29625584/temporomandibular-joint-regeneration-proposal-of-a-novel-treatment-for-condylar-resorption-after-orthognathic-surgery-using-transplantation-of-autologous-nasal-septum-chondrocytes-and-the-first-human-case-report
#12
Ricardo de Souza Tesch, Esther Rieko Takamori, Karla Menezes, Rosana Bizon Vieira Carias, Cláudio Leonardo Milione Dutra, Marcelo de Freitas Aguiar, Tânia Salgado de Sousa Torraca, Alexandra Cristina Senegaglia, Cármen Lúcia Kuniyoshi Rebelatto, Debora Regina Daga, Paulo Roberto Slud Brofman, Radovan Borojevic
BACKGROUND: Upon orthognathic mandibular advancement surgery the adjacent soft tissues can displace the distal bone segment and increase the load on the temporomandibular joint causing loss of its integrity. Remodeling of the condyle and temporal fossa with destruction of condylar cartilage and subchondral bone leads to postsurgical condylar resorption, with arthralgia and functional limitations. Patients with severe lesions are refractory to conservative treatments, leading to more invasive therapies that range from simple arthrocentesis to open surgery and prosthesis...
April 7, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29621840/brucellosis
#13
Siobhan M Mor, Anke K Wiethoelter, Peter D Massey, Jennifer Robson, Kathryn Wilks, Penny Hutchinson
BACKGROUND: Brucellosis, also known as undulant, Mediterranean or Malta fever, is a systemic infection that causes fever, sweats, arthralgias and myalgias. A globally important disease, brucellosis is re-emerging in Australia in association with feral pig hunting activities. OBJECTIVE: This article aims to provide clinicians with an overview of brucellosis, covering epidemiology, clinical features, diagnosis, management and prevention. DISCUSSION: Brucellosis should be suspected in all patients with non-specific, flu-like illness who fall into one of the major risk groups (feral pig hunters, overseas travellers and migrants)...
March 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29621839/q-fever
#14
Keith Eastwood, Peter D Massey, Penny Hutchinson, Debra van den Berg, Katrina Bosward, Stephen R Graves
BACKGROUND: Q fever often presents as an undifferentiated febrile illness. Cases occur throughout Australia, with higher rates occurring in northern New South Wales and southern Queensland. OBJECTIVE: This article aims to provide clinicians with an overview of Q fever, and covers epidemiology, clinical features, laboratory diagnosis, sequelae, management and prevention. DISCUSSION: In Australia, Q fever is the most commonly reported zoonotic disease...
March 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29610684/immune-toxicity-with-checkpoint-inhibition-for-metastatic-melanoma-case-series-and-clinical-management
#15
Anna J Lomax, Jennifer Lim, Robert Cheng, Arianne Sweeting, Patricia Lowe, Neil McGill, Nicholas Shackel, Elizabeth L Chua, Catriona McNeil
Immune checkpoint inhibitors (anti-PD-1 and anti-CTLA-4 antibodies) are a standard of care for advanced melanoma. Novel toxicities comprise immune-related adverse events (irAE). With increasing use, irAE require recognition, practical management strategies, and multidisciplinary care. We retrospectively evaluated the incidence, kinetics, and management of irAE in 41 patients receiving anti-PD-1 antibody therapy (pembrolizumab) for advanced melanoma. 63% received prior anti-CTLA-4 antibody therapy (ipilimumab)...
2018: Journal of Skin Cancer
https://www.readbyqxmd.com/read/29597050/did-fr%C3%A3-d%C3%A3-ric-chopin-die-from-heart-failure
#16
A Perciaccante, P Charlier, C Negri, A Coralli, O Appenzeller, R Bianucci
On October 17, 1849, Poland's greatest composer, Frédéric Chopin (1810-1849) died aged 39. His cause of death remains unknown. An investigation of the documental sources was performed to reconstrcuct the medical history of the artist. Since his earliest years, his life had been dominated by poor health. Recurrent episodes of cough, fever, headaches, lymphadenopathy- a series of symptoms that may be attributed to viral respiratory infections- manifested in his teens. Later in life, he had chest pain, hemoptysis, hematemesis, neuralgia, and arthralgia...
March 26, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29596210/sacroiliitis-in-children-with-familial-mediterranean-fever
#17
Fatma Aydin, Z Birsin Özçakar, Nilgün Çakar, Elif Çelikel, Nermin Uncu, Banu Çelikel Acar, Fatoş Yalçinkaya
BACKGROUND/OBJECTIVE: Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterized by recurrent, self-limited attacks of fever with serositis. Various diseases were reported to be associated with FMF. The aim of this study was to investigate the frequency and characteristics of sacroiliitis in children with FMF. METHODS: Files of FMF patients who had been seen in 2 reference hospitals in Ankara were retrospectively evaluated. Patients with FMF and concomitant sacroiliitis were included to the study...
March 29, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29588874/clinical-and-laboratory-profile-of-zika-and-dengue-infected-patients-lessons-learned-from-the-co-circulation-of-dengue-zika-and-chikungunya-in-brazil
#18
Elzinandes Leal Azeredo, Flavia Barreto Dos Santos, Luciana Santos Barbosa, Thiara Manuele Alves Souza, Jessica Badolato-Corrêa, Juan Camilo Sánchez-Arcila, Priscila Conrado Guerra Nunes, Luzia Maria de-Oliveira-Pinto, Ana Maria de Filippis, Márcia Dal Fabbro, Izilyanne Hoscher Romanholi, Rivaldo Venancio da Cunha
BACKGROUND: The current triple epidemic caused by dengue, zika and chikungunya constitutes a serious health problem in Brazil. The aim of this study was to investigate acute samples (up to the 7 days of symptoms) from patients presenting acute fever syndrome suspected as arboviral infection and characterize the clinical and laboratorial profile during the co-circulation of dengue, zika and chikungunya in Campo Grande, Mato Grosso do Sul (MS), midwest region of Brazil. METHODS: All suspected cases (n=134) were tested by using serological and molecular diagnostic tests including DENV, ZIKV and CHIKV RT-PCR, Dengue nonstructural protein 1 (NS1) antigen capture ELISA, anti- DENV IgM ELISA and anti-CHIKV IgM ELISA...
February 15, 2018: PLoS Currents
https://www.readbyqxmd.com/read/29588298/severe-immune-thrombocytopaenia-in-a-patient-taking-benznidazole-for-chronic-chagas-disease
#19
Clara Crespillo-Andújar, María Calbacho Robles, Francesca F Norman, Jose A Pérez-Molina
Chagas disease is a parasitic disease that mostly affects Latin American countries, but it has currently become a worldwide epidemic due to migration. Both drugs marketed for its treatment (benznidazole and nifurtimox) are associated with a high rate of adverse reactions. Benznidazole is preferred initially because of its more favourable toxicity profile and perceived greater efficacy. Hypersensitivity dermatological reactions, gastrointestinal and neurological disturbances represent the most common drug-related adverse events...
March 27, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29584607/calcinosis-cutis-and-negative-pressure-wound-therapy-as-adjuncts-to-surgical-management-case-report-and-review-of-the-literature
#20
Florian Radu, Masaru Nishiaoki, Martine A Louis
Calcinosis cutis (CC), or calcium deposition in soft tissue, can cause significant morbidity associated with arthralgias and ulceration. This condition has an elusive pathophysiology and is often associated with autoimmune disorders, significantly impacting the disease burden. The clinical presentation of CC varies, and there is no gold standard treatment modality. The case of a 50-year-old woman with scleroderma and a rare presentation of milky drainage of a left hip ulcer secondary to underlying CC that was treated successfully with surgery and negative pressure wound therapy is reported herein...
March 2018: Wounds: a Compendium of Clinical Research and Practice
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