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Arthralgia

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https://www.readbyqxmd.com/read/29450850/recurrent-fever-and-arthralgia-as-the-presentation-of-tumor-necrosis-factor-receptor-associated-periodic-syndrome-traps-in-a-chinese-girl-a-case-report-and-review-of-the-literature
#1
REVIEW
Yanxia Chen, Xingqi Huang, Sujie Zheng, Zhongliang Zhu, Wei Yang, Jinlin Liu
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is characterized by recurrent episodes of inflammation with fever, abdominal pain, chest pain, rash, myalgia, arthralgia, conjunctivitis, and periorbital edema. This condition is a rare autosomal dominant disease that is strongly associated with heterozygous mutations in the tumor necrosis factor (TNF) receptor super family 1A (TNFRSF1A) gene. This condition is believed to be more common in Western countries than in Asian countries, and the AA amyloidosis rate for European countries is estimated to be 10%...
February 15, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29443756/ulcerative-colitis-followed-by-the-development-of-typical-intestinal-beh%C3%A3-et-disease-a-case-report
#2
Zhenhua Zhu, Xu Shu, Shunhua Long, Xiaozhen Jiang, Nonghua Lu, Xuan Zhu, Wangdi Liao
RATIONALE: Intestinal Behçet disease (intestinal BD) and inflammatory bowel disease (IBD) share a lot of characteristics, including genetic background, clinical manifestations, and therapeutic strategies, especially the extraintestinal manifestations, such as oral ulcers, arthralgia, eye lesions, skin lesions, etc, but the coexistence of these 2 diseases are uncommon. Behçet disease with gastrointestinal involvement in ulcerative colitis (UC) patient has been reported in just 1 previous case report, but, which can not be diagnosed as definite intestinal BD based on Korean novel diagnositic criteria due to lacking the typical ileocecal ulcer...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442401/single-arm-phase-ii-study-of-oral-vitamin-b12-for-the-treatment-of-musculoskeletal-symptoms-associated-with-aromatase-inhibitors-in-women-with-early-stage-breast-cancer
#3
Aleli Campbell, Rosalinda Heydarian, Cecilia Ochoa, Alok Kumar Dwivedi, Zeina A Nahleh
Breast cancer patients receiving endocrine therapy with aromatase Inhibitors (AIs) often experience musculoskeletal and joint-related side effects. The purpose of this study was to evaluate the effect of Vitamin B12 supplements on musculoskeletal symptoms such as pain and arthralgias induced by AIs and to correlate response with serum and inflammatory biomarkers. Upon receiving approval by the Institutional Review Board (IRB), the majority of the patients consented into the study were treated at the Texas Tech Breast Care Center...
February 14, 2018: Breast Journal
https://www.readbyqxmd.com/read/29441490/zika-virus-outbreak-a-review-of-neurological-complications-diagnosis-and-treatment-options
#4
REVIEW
Veerendra Koppolu, T Shantha Raju
Zika virus (ZIKV) is an arbovirus transmitted mainly by mosquitos of Aedes species. The virus has emerged in recent years and spread throughout North and South Americas. The recent outbreak of ZIKV started in Brazil (2015) has resulted in infections surpassing a million mark. Contrary to the previous beliefs that Zika causes mildly symptomatic infections fever, headache, rash, arthralgia, and conjunctivitis, the recent outbreak associated ZIKV to serious neurological complications such as microcephaly, Guillain-Barré syndrome, and eye infections...
February 13, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29441299/livedo-racemosa-reticulated-ulcerations-panniculitis-and-violaceous-plaques-in-a-46-year-old-woman
#5
Alfredo Agulló, Brian Hinds, Mónica Larrea, Ignacio Yanguas
Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) that has conventional cutaneous manifestations of DM, but paradoxically, little or no muscle involvement. In 2005, a novel antibody was described in association with CADM - anti-melanoma differentiation-associated gene 5 (anti-MDA5). Patients with this serologic marker have a characteristic mucocutaneous phenotype consisting of skin ulceration among other signs. We describe the case of a 46-year-old woman with CADM, elevated anti-MDA5 autoantibodies, and unusual clinical features (livedo racemosa, florid acral edema) among the classical phenotype of MDA5 DM (arthralgias, ulcerations, panniculitis) and classical DM lesions (Gottron papules, heliotrope rash)...
January 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29431292/chikungunya-a-rheumatologist-s-perspective
#6
REVIEW
Shefali Khanna Sharma, Sanjay Jain
Chikungunya (CHIK), a viral infection, is transmitted by Aedes mosquitoes. It is characterized by a phase of acute infection, which is sometimes followed by chronic rheumatisim in the form of arthralgia or myalgia that can last for months and even years. Several studies have been conducted to understand the mechanisms underlying inflammation associated with CHIK infection, persistence of viruses in monocytes-macrophages, and their relationship to the chronic symptoms. Chronic arthritis is one of the serious complications of CHIK infection, which is characterized by swelling and acute pain that poorly responds to treatment with analgesics...
February 12, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29427550/clinically-relevant-discrepancies-between-different-rheumatoid-factor-assays
#7
Willem J J Falkenburg, Helen J von Richthofen, Jana Koers, Cas Weykamp, Marco W J Schreurs, Liesbeth E Bakker-Jonges, Inez-Anne Haagen, Willem F Lems, Dörte Hamann, Dirkjan van Schaardenburg, Theo Rispens
BACKGROUND: Accurate measurements of rheumatoid factors (RFs), autoantibodies binding IgG, are important for diagnosing rheumatoid arthritis (RA) and for predicting disease course. Worldwide, various RF assays are being used that differ in technique and target antigens. We studied whether assay choice leads to clinically important discrepancies in RF status and level. METHODS: RF measurements using four commercial RF assays were compared in 32 RF+ samples. Using enzyme-linked immunosorbent assays (ELISAs), the influence of the target antigen source - human IgG (hIgG) versus rabbit IgG (rIgG) - on measured RF levels was investigated in arthralgia patients and RA patients...
February 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29425115/nonstructural-proteins-of-alphavirus-potential-targets-for-drug-development
#8
REVIEW
Farhana Abu Bakar, Lisa F P Ng
Alphaviruses are enveloped, positive single-stranded RNA viruses, typically transmitted by arthropods. They often cause arthralgia or encephalitic diseases in infected humans and there is currently no targeted antiviral treatment available. The re-emergence of alphaviruses in Asia, Europe, and the Americas over the last decade, including chikungunya and o'nyong'nyong viruses, have intensified the search for selective inhibitors. In this review, we highlight key molecular determinants within the alphavirus replication complex that have been identified as viral targets, focusing on their structure and functionality in viral dissemination...
February 9, 2018: Viruses
https://www.readbyqxmd.com/read/29420573/prevalence-of-diagnosed-temporomandibular-disorders-a-cross-sectional-study-in-brazilian-adolescents
#9
Fernanda Mara de Paiva Bertoli, Carolina Dea Bruzamolin, Eduardo Pizzatto, Estela Maris Losso, João Armando Brancher, Juliana Feltrin de Souza
BACKGROUND: The prevalence of signs and symptoms of temporomandibular disorders (TMD) increases during adolescence and adulthood. Few studies have examined TMD prevalence in Brazilian adolescents. AIM: To investigate the prevalence of TMD in Brazilian adolescents. METHODS: A representative population-based sample of 934 adolescents (10-14-years-old) was examined. TMD screening was performed using a questionnaire by the American Academy of Orofacial Pain...
2018: PloS One
https://www.readbyqxmd.com/read/29415070/evidence-for-chikungunya-and-dengue-transmission-in-quelimane-mozambique-results-from-an-investigation-of-a-potential-outbreak-of-chikungunya-virus
#10
Vánio André Mugabe, Sadia Ali, Imelda Chelene, Vanessa Onofre Monteiro, Onélia Guiliche, Argentina Felisbela Muianga, Flora Mula, Virgílio António, Inocêncio Chongo, John Oludele, Kerstin Falk, Igor A Paploski, Mitermayer G Reis, Uriel Kitron, Beate M Kümmerer, Guilherme S Ribeiro, Eduardo Samo Gudo
BACKGROUND: In January 2016, health authorities from Zambézia province, Mozambique reported the detection of some patients presenting with fever, arthralgia, and a positive result for chikungunya in an IgM-based Rapid Diagnostic Test (RDT). We initiated a study to investigate a potential chikungunya outbreak in the city of Quelimane. METHODS/PRINCIPAL FINDINGS: From February to June 2016, we conducted a cross-sectional study enrolling febrile patients attending five outpatient health units in Quelimane...
2018: PloS One
https://www.readbyqxmd.com/read/29412042/musculoskeletal-pain-and-menopause
#11
Fiona E Watt
Musculoskeletal pain, arthralgia and arthritis are all more common in women, and their frequency increases with age and in some appears to be associated with the onset of menopause. The clinical assessment, investigation and management of women presenting with musculoskeletal pain, arthralgia or arthritis at the time of menopause are reviewed. Common causes of arthralgia and arthritis in this population are discussed. The epidemiological and trials evidence for the effects of hormone replacement therapy on musculoskeletal pain and arthritis (primarily from RCTs of HRT for other menopausal symptoms) are discussed...
January 1, 2018: Post Reproductive Health
https://www.readbyqxmd.com/read/29401313/can-an-increase-in-autoantibody-levels-predict-arthritis-in-arthralgia-patients
#12
Marian H van Beers-Tas, Martijn M Stuiver, Margret H M T de Koning, Lotte A van de Stadt, Ronald B Geskus, Dirkjan van Schaardenburg
No abstract text is available yet for this article.
February 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29395449/do-signs-of-an-effusion-of-the-temporomandibular-joint-on-magnetic-resonance-imaging-correlate-with-signs-and-symptoms-of-temporomandibular-joint-disease
#13
N Thomas, D E Harper, S Aronovich
Effusions are common among patients with disorders of the temporomandibular joint (TMJ), but publications are limited and results inconsistent about the correlation between them and important clinical variables, in particular severity of pain and degenerative disease. We organised a retrospective study of patients who presented for the evaluation and management of arthralgia of the TMJ and myofascial pain at the University of Michigan between 2011 and 2014. Inclusion criteria were: patients who had pain that was primarily arthrogenous, and coexisting myogenous pain, who had had initial non-surgical treatment, and arthroscopy of the TMJ with or without intramuscular injection of onabotulinumtoxinA (Botox,® Allegan, Weston, Fl, USA)...
January 25, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29395180/mercury-poisoning-in-a-toddler-from-home-contamination-due-to-skin-lightening-cream
#14
Michael R Ori, Jaiva B Larsen, Farshad Mazda Shirazi
A 17-month-old child presented with hypertension, fussiness, constipation, and arthralgia due to mercury toxicity from a skin-lightening cosmetic used by her mother and grandmother. Blood mercury level was 26 mcg/L and urine level was 243 mcg/g creatinine. She was chelated with succimer. The home was contaminated and needed remediation.
January 30, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29384960/dabrafenib-plus-trametinib-for-compassionate-use-in-metastatic-melanoma-a-strobe-compliant-retrospective-observational-postauthorization-study
#15
Salvador Martín Algarra, Virtudes Soriano, Luis Fernández-Morales, Miguel-Ángel Berciano-Guerrero, Karmele Mujika, José Luis Manzano, Teresa Puértolas Hernández, Ainara Soria, Delvys Rodríguez-Abreu, Enrique Espinosa Arranz, Javier Medina Martínez, Ivan Márquez-Rodas, Jordi Rubió-Casadevall, María Eugenia Ortega, José Miguel Jurado García, María José Lecumberri Biurrun, Isabel Palacio, María Rodríguez de la Borbolla Artacho, Javier Pérez Altozano, Victoria Eugenia Castellón Rubio, Almudena García, Pablo Luna, Anabel Ballesteros, Ovidio Fernández, Jose Antonio López Martín, Alfonso Berrocal, Ana Arance
The main objective of the study was to evaluate the efficacy and safety of dabrafenib alone or combined with trametinib for compassionate use in patients with metastatic melanoma.This retrospective, observational study involved 135 patients with unresectable stage IIIC or stage IV melanoma from an expanded-access program at 30 Spanish centers.Forty-eight patients received dabrafenib monotherapy and 87 received combination dabrafenib and trametinib; 4.4% and 95.6% of the patients had stage IIIC and IV melanoma, respectively...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384877/acute-appendicitis-complicated-with-necrotizing-fasciitis-in-a-patient-with-adult-onset-still-s-disease-a-case-report
#16
Zheng-Hao Huang, Yu-Chen Chiu, Li-Lu Ho, Hsiu-Lung Fan, Chun-Chi Lu
RATIONALE: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, spiking fever, arthralgia/ arthritis, and lymphadenopathy. AOSD sometimes was fatal when it is complicated by macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH). Nonetheless, the literature provides no recommendations for treatment of AOSD patients with severe sepsis. PATIENT CONCERNS: A previously healthy 65-year-old man with history of AOSD was referred to our hospital for persistent right lower quadrant abdominal pain for 2 days...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29382880/antibody-mediated-enhancement-aggravates-chikungunya-virus-infection-and-disease-severity
#17
Fok-Moon Lum, Thérèse Couderc, Bing-Shao Chia, Ruo-Yan Ong, Zhisheng Her, Angela Chow, Yee-Sin Leo, Yiu-Wing Kam, Laurent Rénia, Marc Lecuit, Lisa F P Ng
The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specific antibodies have been shown to control virus clearance, but antibodies present at sub-neutralizing concentrations can also augment virus infection that exacerbates disease severity. To explore this occurrence, CHIKV infection was investigated in the presence of CHIKV-specific antibodies in both primary human cells and a murine macrophage cell line, RAW264...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29382005/successful-treatment-of-pachydermoperiostosis-patients-with-etoricoxib-aescin-and-arthroscopic-synovectomy-two-case-reports
#18
Hengyan Zhang, Bo Yang
RATIONALE: Pachydermoperiostosis (PDP) is a rare hereditary disorder that affects the skin and bones. PDP is characterized by periostosis, digital clubbing, and pachydermia. Previous studies demonstrated that increased prostaglandin E2 (PGE2) levels resulting from defective protein degradation pathways play a crucial role in PDP pathogenesis, and males were more commonly and severely affected than females. Moreover, nearly all PDP patients suffer from refractory arthralgia. Although several different treatment modalities are used for PDP, therapy for this disease remains challenging...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381956/18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-detection-threshold-in-follicular-lymphoma-a-case-report
#19
Sarah Péricart, Guillaume Martin-Blondel, Camille Franchet, Anne Hitzel, Pierre Brousset
RATIONALE: Follicular Lymphoma in situ is generally identified as reactive follicular hyperplasia in which some of the hyperplastic germinal centers are colonized by few lymphoma cells. These cells can be detected through their strong 18F-Fluorodeoxyglucose avidity. PATIENT CONCERNS: We report the case of a 70 year-old patient with arthralgia, weight loss and chronic fever over two months. A paraneoplastic polymyalgia rheumatica was initially suspected on abnormal 18F fluoro-deoxyglucose positron emission tomography (PET) pictures in two inguinal lymph nodes with a standardized uptake value at 8...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29380528/efficacy-of-management-strategies-for-aromatase-inhibitor-induced-arthralgia-in-breast-cancer-patients-a-systematic-review
#20
REVIEW
Nicole Nahm, Susie Mee, Gavin Marx
Aromatase inhibitors are the gold standard in the treatment of hormone receptor-positive breast cancer, but lead to an arthralgia syndrome which is implicated in 13-22% of noncompliance. This is the first systematic review of the efficacy of existing management strategies for this side effect. Eligible studies were retrieved from computer searches of Medline, Cochrane and Embase and the significant intervention groups were identified. The risk of bias of selected studies was evaluated and the relevant data items were extracted, summarized and analyzed...
January 30, 2018: Asia-Pacific Journal of Clinical Oncology
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