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https://www.readbyqxmd.com/read/29224680/pregnancy-in-systemic-lupus-erythematosus-and-antiphospholipid-syndrome
#1
REVIEW
Rebecca Fischer-Betz, Christof Specker
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with a high prevalence in females of childbearing age. Pregnancy in SLE nowadays has favorable outcomes for the majority of women. However, flares of disease activity, preeclampsia, fetal loss, and preterm birth are well-known risks in such pregnancies. Anti-SS-A(Ro)/SS-B(La) antibodies put fetuses at risk for congenital heart block and neonatal lupus. Several risk factors for adverse pregnancy outcomes have been identified. Women with antiphospholipid antibodies or antiphospholipid syndrome and lupus nephritis represent a group with high risk for obstetric complications...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29210161/do-time-of-birth-unit-volume-and-staff-seniority-affect-neonatal-outcome-in-deliveries-at-%C3%A2-34-0-weeks-of-gestation
#2
P Reif, G Pichler, A Griesbacher, G Lehner, W Schöll, U Lang, H Hofmann, D Ulrich
OBJECTIVE: We investigated whether time of birth, unit volume, and staff seniority affect neonatal outcome in neonates born at ≥34+0 weeks of gestation. DESIGN: Population-based prospective cohort study. SETTING: Ten public hospitals in the Austrian province of Styria. SAMPLE: A total of 87 065 neonates delivered in the period 2004-2015. METHODS: Based on short-term outcome data, generalised linear mixed models were used to calculate the risk for adverse and severely adverse neonatal outcomes according to time of birth, unit volume, and staff seniority...
December 6, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29202976/perinatal-outcomes-after-natural-conception-versus-in%C3%A2-vitro-fertilization-ivf-in-gestational-surrogates-a-model-to-evaluate-ivf-treatment-versus-maternal-effects
#3
Irene Woo, Rita Hindoyan, Melanie Landay, Jacqueline Ho, Sue Ann Ingles, Lynda K McGinnis, Richard J Paulson, Karine Chung
OBJECTIVE: To study the perinatal outcomes between singleton live births achieved with the use of commissioned versus spontaneously conceived embryos carried by the same gestational surrogate. DESIGN: Retrospective cohort study. SETTING: Academic in vitro fertilization center. PATIENT(S): Gestational surrogate. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Pregnancy outcome, gestational age at birth, birth weight, perinatal complications...
December 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29201670/coexistent-circumvallate-placenta-and-battledore-insertion-of-umbilical-cord-resulting-in-grave-obstetric-outcome-a-case-report
#4
Nalini Sharma, Rituparna Das, Sushila Salam, Roma Jethani, Ahanthem Santa Singh
Background: Various placental and cord abnormalities have been known to adversely affect the obstetric outcome. Circumvallate placenta and Battledore insertion of the umbilical cord are both rare and known to be associated with poor obstetric outcome individually. Case Presentation: In this case report, the woman presented at 8 months of gestation with preeclampsia with IUFD to North Easter Indira Gandhi Regional Institute of Health and Medical Science Shillong on 22/7/16 and delivered a macerated fetus vaginally...
October 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29194189/ovarian-yolk-sac-tumors-does-age-matter
#5
Cecile Faure Conter, Caihong Xia, David Gershenson, Jean Hurteau, Al Covens, Farzana Pashankar, Mark Krailo, Deborah Billmire, Catherine Patte, Brice Fresneau, Furqan Shaikh, Sara Stoneham, James Nicholson, Matthew Murray, Anne Lindsay Frazier
BACKGROUND: Whereas among pediatric oncologists, ovarian yolk sac tumor (O-YST) is considered a chemosensitive tumor, it is often cited as an adverse prognostic factor in adult women with ovarian germ cell tumors. METHODS: The Malignant Germ Cell International Consortium data set included 6 pediatric clinical trials (United States, United Kingdom, and France) and 2 adult gynecology clinical trials (United States). Any patient with an O-YST that was International Federation of Gynecology and Obstetrics stage IC or higher and treated with a platinum-based chemotherapy was eligible...
November 30, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29191448/adverse-perinatal-outcomes-associated-with-crown-rump-length-discrepancy-in-in%C3%A2-vitro-fertilization-pregnancies
#6
Kristy Cho, Caitlin Dunne, Arianne Y K Albert, Jon C Havelock
OBJECTIVE(S): To determine whether an association exists between small crown-rump length (CRL) and adverse obstetrical outcomes in pregnancies conceived by IVF and to compare a CRL reference based on IVF pregnancies to a reference based on spontaneous pregnancies. DESIGN: Retrospective cohort study. CRL was classified as small by comparing it with the local university hospital maternal fetal medicine standard and the Monash IVF reference chart. SETTING: University-affiliated fertility center...
November 28, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29174282/intranasal-dexmedetomidine-in-termination-of-first-trimester-pregnancy-of-suction-evacuation
#7
Hang Shi, Duo Yang, Jie Liu
BACKGROUND AND AIM: Deep sedation without intubation for termination of first trimester pregnancy of suction evacuation entails use of sedatives such as propofol or a combination of propofol and sulfentanil, with unwanted complications. Dexmedetomidine is an α2-adrenoreceptor agonist which provides sedation, anxiolysis and analgesia, without any of the complications associated with the popular sedatives. METHODS: A total number of 90 patients were randomized to three groups: 1...
September 24, 2017: Asian Journal of Anesthesiology
https://www.readbyqxmd.com/read/29173607/clinical-features-and-outcomes-of-acute-coronary-syndrome-in-women-with-previous-pregnancy-complications
#8
Sophie Grand'Maison, Louise Pilote, Kenny Schlosser, Duncan J Stewart, Marisa Okano, Natalie Dayan
BACKGROUND: Women with previous cardiometabolic complications of pregnancy experience double the risk of cardiovascular disease. However, few data exist on the clinical effect of these complications at the time of an acute coronary syndrome (ACS). The objective of this work was to compare risk factors, clinical features, and outcomes among women with premature ACS with or without previous pregnancy complications (gestational diabetes and/or hypertensive disorders of pregnancy). METHODS: Data were obtained from a multicentre cohort of individuals hospitalized with premature ACS...
December 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29171962/maternal-demographic-factors-associated-with-emergency-caesarean-section-for-non-reassuring-foetal-status
#9
Ramali Mendis, Christopher Flatley, Sailesh Kumar
OBJECTIVES: This study aimed to determine maternal and obstetric factors associated with emergency caesarean section (CS) for non-reassuring foetal status (NRFS). MATERIALS AND METHODS: This was a retrospective analysis of term singleton births between January 2007 and December 2015 at the Mater Mother's Hospital in Brisbane. The study group comprised all cases of emergency CS for NRFS, and the control cohort comprised all other births meeting the inclusion criteria but excluding those in the study cohort...
November 24, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29170324/27%C3%A2-the-dipep-diagnosis-of-pe-in-pregnancy-study-can-clinical-assessment-d-dimer-or-chest-x-ray-be-used-to-select-pregnant-or-postpartum-women-with-suspected-pe-for-diagnostic-imaging
#10
Steve Goodacre, Kimberley Horspool, Catherine Nelson-Piercy, Marian Knight, Neil Shephard, Fiona Lecky, Steven Thomas, Beverley Hunt, Gordon Fuller
OBJECTIVE: To determine whether clinical features (in the form of a clinical decision rule) or d-dimer can be used to select pregnant or postpartum women with suspected PE for diagnostic imaging. DESIGN: Observational cohort study augmented with additional cases. SETTING: Consultant-led maternity units participating in the UK Obstetric Surveillance System (UKOSS) and emergency departments and maternity units at eleven prospectively recruiting sites...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29170078/how-common-is-substantial-weight-gain-after-pregnancy
#11
Priya Sumithran, Christine Houlihan, Alexis Shub, Leonid Churilov, Natasha Pritchard, Sarah Price, Elif Ekinci, Joseph Proietto, Michael Permezel
BACKGROUND: Although population-based studies indicate that on average, women gain 1-2kg between pregnancies, women with obesity often attribute its development to childbearing. There is little contemporary data available regarding how commonly this occurs, particularly in women of different body mass index (BMI) categories. The aim of this study was to examine inter-pregnancy weight changes among women at a tertiary obstetric hospital in Melbourne, Australia. METHODS: This was a retrospective review of data from the Birthing Outcomes System electronic record of 19,617 women aged 20 years or older, who delivered at least two consecutive singleton infants at ≥37 weeks' gestation at Mercy Hospital for Women between December 1994 and December 2015...
November 20, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29164591/trend-of-decreasing-length-of-cervical-cone-excision-during-the-last-20-years
#12
F Sopracordevole, N Clemente, G Delli Carpini, G Giorda, A Del Fabro, L Moriconi, G De Piero, L Alessandrini, V Canzonieri, M Buttignol, M Nicodemo, A Ciavattini
OBJECTIVE: The aim of the present investigation was to evaluate the cervical conizations performed in the last 20 years in a single institution, with a particular interest in analyzing the trend of the length of cone excisions. PATIENTS AND METHODS: A retrospective cohort study of women who underwent a CO2-laser cervical conization between January 1996 and December 2015. Cytological abnormalities on referral pap smear, colposcopic findings and pertinent clinical and socio-demographic characteristics of each woman were collected...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29162956/risk-assessment-at-11-14-week-antenatal-visit-a-tertiary-referral-center-experience-from-south-india
#13
Anusha Vellamkondu, Akhila Vasudeva, Rajeshwari G Bhat, Asha Kamath, Sapna V Amin, Lavanya Rai, Pratap Kumar
Background: Present study carried out in a tertiary referral hospital in South India attempts to determine the predictive value of integrated screening at 11-14-week antenatal visit. Objectives: To determine the detection rate of fetal abnormalities at 11-14 weeks and also to predict the placental dysfunction disorders based on early integrated evaluation. Method: Integrated screening performed on 440 women between 11 and 14 weeks, including detailed maternal history [medical history, bad obstetric history (BOH)], body mass index (BMI), mean arterial pressure (MAP), detailed ultrasound and maternal serum biochemistry as part of combined first-trimester screening for aneuploidy...
December 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29158370/ovarian-and-uterine-functions-in-female-survivors-of-childhood-cancers
#14
REVIEW
Ozgur Oktem, Samuel S Kim, Ugur Selek, Glenn Schatmann, Bulent Urman
Adult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29157354/identification-of-vulnerability-within-a-child-and-family-health-service
#15
Katarina Kimla, Dania Nathanson, Susan Woolfenden, Karen Zwi
Objective The aims of the present study were to describe the prevalence of vulnerability in a cohort of newborns, identify the factors that increase the risk of vulnerability and examine whether those who are most vulnerable are receiving home visits.Methods A prospective cross-sectional study was performed using data collected from questionnaires completed by child and family health nurses and obstetric discharge summaries for each mother-baby dyad. Descriptive frequencies and percentages are used to describe the proportions of children who were vulnerable, offered services and had risk factors for vulnerability...
November 21, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29157196/perinatal-outcomes-of-hypertensive-disorders-in-pregnancy-at-a-tertiary-hospital-in-ghana
#16
Kwame Adu-Bonsaffoh, Michael Y Ntumy, Samuel A Obed, Joseph D Seffah
BACKGROUND: Hypertensive disorders in pregnancy remain a major global health issue not only because of the associated high adverse maternal outcomes but there is a close accompaniment of significant perinatal morbidity and mortality especially in Sub-Saharan Africa (SSA). However, the perinatal burden of HDP in Ghana has not been explored. We conducted this study to determine the perinatal outcomes of HDP at a tertiary hospital in Ghana. METHODS: A cross-sectional study conducted between January to February 2013 at Korle Bu Teaching Hospital (KBTH) in Accra, Ghana...
November 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29155840/indications-and-determinants-of-caesarean-section-delivery-evidence-from-a-population-based-study-in-matlab-bangladesh
#17
Tahmina Begum, Aminur Rahman, Herfina Nababan, Dewan Md Emdadul Hoque, Al Fazal Khan, Taslim Ali, Iqbal Anwar
BACKGROUND AND METHODS: Caesarean section (C-section) is a major obstetric intervention for saving lives of women and their newborns from pregnancy and childbirth related complications. Un-necessary C-sections may have adverse impact upon maternal and neonatal outcomes. In Bangladesh there is paucity of data on clinical indication of C-section at population level. We conducted a retrospective study in icddr,b Health and Demographic Surveillance System (HDSS) area of Matlab to look into the indications and determinants of C-sections...
2017: PloS One
https://www.readbyqxmd.com/read/29153684/impact-of-maternal-serum-uric-acid-on-perinatal-outcome-in-women-with-hypertensive-disorders-of-pregnancy-a-prospective-study
#18
Naina Kumar, Amit Kant Singh, Bhavya Maini
INTRODUCTION: Worldwide hypertensive disorder of pregnancy is major cause of maternal and perinatal morbidity, mortality. AIM: To study impact of maternal serum uric acid on perinatal outcome in women with hypertensive disorder of pregnancy. METHODOLOGY: Present study was conducted in Obstetrics and Gynecology Department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017). Total 110 pregnant women >-34weeks with hypertensive disorder of pregnancy were divided into three groups; Gestational hypertension (n = 35), Pre-eclampsia (n = 49), Eclampsia (n = 26)...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29146013/-chronic-histiocytic-intervillositis-diagnosis-and-management
#19
A Mekinian, N Costedoat-Chalumeau, L Carbillon, A Coulomb-L'Hermine, V Le Guern, A Masseau, E Lazaro, J Cohen, M Bornes, G Kayem, O Fain
Chronic intervillositis is a rare condition, which is associated with severe obstetrical outcome and high recurrence rate. Obstetrical adverse events are intrauterine growth restriction, recurrent early miscarriages, intrauterine deaths and prematurity by placental insufficiency. The determination of the extension and the intensity of the chronic intervillositis are not currently standardized. High rates of recurrence have been described, but actually there is no reliable predictive biomarker. No treatment is currently validated, but the use of immunomodulatory drugs could be justified by the possible autoimmune or allo-immune origin...
November 13, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29141482/obstetric-practice-guidelines-labor-s-love-lost
#20
Wayne R Cohen, Emanuel A Friedman
Implementation of clinical practice guidelines may moderate health care costs, improve care, reduce medicolegal liability, and provide a uniformity in care allowing meaningful investigation of treatments and outcomes. However, new guidelines are often uncritically embraced by clinicians, risk management organizations, insurance companies, and the courts as the standard of care. Adoption of incompletely vetted recommendations can lead to patient harm. Recent recommendations made by the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine for assessment and management of labor provide an example of well-intended guidelines adopted uncritically...
November 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
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