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https://www.readbyqxmd.com/read/28333275/anti-m%C3%A3-llerian-hormone-inhibits-activation-and-growth-of-bovine-ovarian-follicles-in-vitro-and-is-localized-to-growing-follicles
#1
M Y Yang, R A Cushman, J E Fortune
STUDY QUESTION: Does anti-Müllerian hormone (AMH) inhibit activation (initiation of growth) of primordial follicles and attenuate the growth of primary follicles in cattle, an excellent animal model for human ovarian follicular development? SUMMARY ANSWER: AMH inhibited activation of bovine primordial follicles and attenuated the growth of activated follicles in vitro. WHAT IS KNOWN ALREADY: In mice null mutant for AMH, the pool of primordial follicles is depleted prematurely and AMH inhibits follicle activation in vitro...
March 17, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28323933/research-resource-transcriptional-dynamics-of-cultured-human-villous-cytotrophoblasts
#2
Joshua F Robinson, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Terrence Dent, Helia Seifikar, Emily G Hamilton, Susan J Fisher
During human pregnancy, cytotrophoblasts (CTBs) play key roles in uterine invasion, vascular remodeling, and anchoring of the feto-placental unit. Due to the challenges associated with studying human placentation in utero, cultured primary villous CTBs are used as a model of the differentiation pathway that leads to invasion of the uterine wall. In vitro, CTBs emulate in vivo cell behaviors, such as migration, aggregation and substrate penetration. While some of the molecular features related to these cell behaviors have been described, the underlying mechanisms, at a global level, remain undefined at mid-gestation...
March 8, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323386/the-association-of-maternal-lymphatic-markers-and-critical-congenital-heart-defects-in-the-fetus-a-population-based-case-control-study
#3
Martina A Steurer, Mary E Norton, Rebecca J Baer, Gary M Shaw, Sheila Keating, Anita J Moon-Grady, Christina D Chambers, Laura L Jelliffe-Pawlowski
The objective ot this study was to investigate whether lymphatic markers measured in women during the second trimester are associated with critical congenital heart defects (CCHDs) in offspring. This is a retrospective cohort study of pregnant women who participated in the California Prenatal Screening Program. CCHD data in the offspring was captured by linking birth certificate data with hospital patient discharge records. Second trimester samples were assayed for vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) AA/BB, and PDGF AB...
March 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28320233/does-cervical-cerclage-decrease-preterm-birth-in-twin-pregnancies-with-a-short-cervix
#4
Tracy M Adams, Timothy J Rafael, Nadia B Kunzier, Supriya Mishra, Rose Calixte, Anthony M Vintzileos
PURPOSE: To determine if use of cerclage in twin gestations with mid-trimester short cervix is associated with decreased preterm birth rate. STUDY DESIGN: This is a retrospective cohort of twin gestations identified with cervical length of ≤2.5cm before 24 weeks gestation through the perinatal ultrasound database of two institutions from 2008-2014. Patients with and without cerclage were compared for a primary outcome of preterm birth at <35 weeks. A pre-planned sub-group analysis of patients with cervical length ≤1...
March 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28295722/cerclage-for-short-cervix-on-ultrasound-in-singleton-gestations-without-prior-spontaneous-preterm-birth-a-systematic-review-and-meta-analysis-of-trials-using-individual-patient-level-data
#5
REVIEW
Vincenzo Berghella, Andrea Ciardulli, Orion A Rust, Meekai To, Katsufumi Otsuki, Sietske Althuisius, Kypros Nicolaides, Amanda Roman, Gabriele Saccone
OBJECTIVE: The aim of this systematic review and meta-analysis was to quantify the efficacy of cervical cerclage in preventing preterm birth (PTB) in asymptomatic singleton pregnancies with a mid-trimester short transvaginal ultrasound cervical length (TVU CL) and without prior spontaneous PTB. METHODS: Electronic databases were searched from inception of each database until February 2017. No language restrictions were applied. We included all randomized controlled trials (RCTs) of asymptomatic singleton pregnancies without prior spontaneous PTB screened with TVU CL, found to have a midtrimester short CL <25 mm, and then randomized to management with either cerclage (i...
March 10, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28285640/first-and-second-trimester-gestational-weight-gains-are-most-strongly-associated-with-cord-blood-levels-of-hormones-at-delivery-important-for-glycemic-control-and-somatic-growth
#6
Sheryl L Rifas-Shiman, Abby Fleisch, Marie-France Hivert, Christos Mantzoros, Matthew W Gillman, Emily Oken
BACKGROUND: Excessive gestational weight gain (GWG) during pregnancy is associated with adverse outcomes for mothers and offspring. Early, mid, and late pregnancy GWGs have different associations with fetal growth and later life adiposity, but associations with cord blood hormones, which might predict later health, are not well studied. METHODS: In 978 pregnant women from the pre-birth Project Viva cohort, we calculated trimester-specific GWG using clinically recorded prenatal weights...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28278173/circulating-progenitor-and-angiogenic-cell-frequencies-are-abnormally-static-over-pregnancy-in-women-with-preconception-diabetes-a-pilot-study
#7
Patricia D A Lima, Zhilin Chen, Aysha Tayab, Malia S Q Murphy, Jessica Pudwell, Graeme N Smith, B Anne Croy
Type 1 and 2 diabetes decrease the frequencies and functional capacities of circulating angiogenic cells (CAC). Diabetes also elevates gestational complications. These observations may be interrelated. We undertook pilot studies to address the hypothesis that preconception diabetes deviates known gestational increases in CACs. Cross-sectional study of type 1 diabetic, type 2 diabetic and normoglycemic pregnant women was conducted at 1st, 2nd, and 3rd trimester and compared to a 6mo postpartum surrogate baseline...
2017: PloS One
https://www.readbyqxmd.com/read/28268197/microbial-invasion-of-the-amniotic-cavity-in-mid-trimester-pregnancies-using-molecular-microbiology
#8
Shelley Rowlands, Jennifer A Danielewski, Sepehr N Tabrizi, Susan P Walker, Suzanne M Garland
OBJECTIVE: To determine the frequency of microbial invasion of the amniotic cavity in the midtrimester of pregnancy in patients undergoing amniocentesis for clinical indications. STUDY DESIGN: Prospective investigation of the amniotic fluid of 344 asymptomatic women recruited in mid pregnancy for the presence of microbial DNA. Amniotic samples obtained at time of amniocentesis for genetic testing on women between 15-22 weeks gestation were tested specifically for the presence of Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis and Mycoplasma genitalium, as well as for other bacteria and fungi using broad-range PCR only...
March 4, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28268196/prenatal-ultrasound-diagnosis-and-outcome-of-placenta-previa-accreta-after-caesarean-delivery-a-systematic-review-and-meta-analysis
#9
REVIEW
Eric Jauniaux, Amar Bhide
BACKGROUND: Women with a history of previous caesarean delivery, presenting with a placenta previa have become the largest group with the highest risk for placenta previa accreta. OBJECTIVE: To evaluate the accuracy of ultrasound imaging in the prenatal diagnosis of placenta accreta and the impact of the depth of villous invasion on management in women presenting with placenta previa or low-lying placenta and with one or more prior caesarean deliveries. STUDY DESIGN: Data sources: We searched PubMed, Google Scholar, clinicalTrials...
March 4, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28266160/interventions-for-women-with-mid-trimester-short-cervix-which-ones-work
#10
EDITORIAL
A M Vintzileos, G H A Visser
No abstract text is available yet for this article.
March 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28255007/the-human-chorion-contains-definitive-hematopoietic-stem-cells-from-the-15-th-week-of-gestation
#11
Marcus O Muench, Mirhan Kapidzic, Matthew Gormley, Alan G Gutierrez, Kathryn L Ponder, Marina E Fomin, Ashley I Beyer, Haley Stolp, Zhongxia Qi, Susan J Fisher, Alicia Bárcena
We examined the contribution of the fetal membranes, amnion and chorion, to human embryonic and fetal hematopoiesis. A population of cells displaying a hematopoietic progenitor phenotype (CD34(++/+)CD45(low) cells) of fetal origin was present in the chorion at all gestational ages, associated with stromal cells or near blood vessels, but was absent in the amnion. Prior to 15 weeks of gestation, they lacked hematopoietic in vivo engraftment potential. Differences in the chemokine receptor and β1 integrin expression profiles of progenitors between the 1(st) and 2(nd) trimesters suggest that these cells had gestationally-regulated responses to homing signals and/or adhesion mechanisms that influenced their ability to colonize the stem cell niche...
March 2, 2017: Development
https://www.readbyqxmd.com/read/28181996/blood-pressure-during-pregnancy-neonatal-size-and-altered-body-composition-the-healthy-start-study
#12
A P Starling, A L B Shapiro, K A Sauder, J L Kaar, B M Ringham, D H Glueck, H L Galan, D Dabelea
OBJECTIVE: The objective of this study is to estimate associations between changes in maternal arterial pressure during normotensive pregnancies and offspring birth weight and body composition at birth. STUDY DESIGN: Prospective study of 762 pregnant normotensive Colorado women, recruited from outpatient obstetrics clinics. Repeated arterial pressure measurements during pregnancy were averaged within the second and third trimesters, respectively. Multivariable regression models estimated associations between second to third trimester changes in arterial pressure and small-for-gestational-age birth weight, fat mass, fat-free mass and percent body fat...
February 9, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28174536/exploring-the-pharmacokinetic-profile-of-remifentanil-in-mid-trimester-gestations-undergoing-fetal-intervention-procedures
#13
Judith A Smith, Roopali V Donepudi, Pedro S Argoti, Anita L Giezentanner, Ranu Jain, Noemi Boring, Elisa Garcia, Kenneth J Moise
Background: Indications for surgery during pregnancy have increased. Specifically fetal interventions have increased from conditions that were considered lethal like twin-twin transfusion syndrome and severe fetal anemia to non-lethal conditions like myelomeningocele. The optimal anesthetic agent for in utero surgery is yet to be determined. Success of the procedure is often dictated by the efficacy of the anesthetic to immobilize the fetus without over-sedating mom. Remifentanil is used as preferred agent due to its short half-life however pharmacokinetics in pregnancy is unknown...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28161306/a-randomized-clinical-trial-of-exercise-during-pregnancy%C3%A2-to%C3%A2-prevent-gestational-diabetes-mellitus-and%C3%A2-improve-pregnancy-outcome-in-overweight-and%C3%A2-obese%C3%A2-pregnant-women
#14
Chen Wang, Yumei Wei, Xiaoming Zhang, Yue Zhang, Qianqian Xu, Yiying Sun, Shiping Su, Li Zhang, Chunhong Liu, Yaru Feng, Chong Shou, Kym J Guelfi, John P Newnham, Huixia Yang
BACKGROUND: Obesity and being overweight are becoming epidemic, and indeed, the proportion of such women of reproductive age has increased in recent times. Being overweight or obese prior to pregnancy is a risk factor for gestational diabetes mellitus, and increases the risk of adverse pregnancy outcome for both mothers and their offspring. Furthermore, the combination of gestational diabetes mellitus with obesity/overweight status may increase the risk of adverse pregnancy outcome attributable to either factor alone...
February 1, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28145653/maternal-characteristics-short-mid-trimester-cervical-length-and-preterm-delivery
#15
Soo Hyun Cho, Kyo Hoon Park, Eun Young Jung, Jung Kyung Joo, Ji Ae Jang, Ha Na Yoo
We aimed to determine the maternal characteristics (demographics, an obstetric history, and prior cervical excisional procedure) associated with a short mid-trimester cervical length (CL, defined as a CL of ≤ 25 mm) and whether having a short cervix explains the association between these maternal characteristics and spontaneous preterm delivery (SPTD, defined as a delivery before 34 weeks). This is a single-center retrospective cohort study of 3,296 consecutive women with a singleton pregnancy who underwent routine CL measurement between 20 and 24 weeks...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28126630/automatic-detection-and-measurement-of-nuchal-translucency
#16
Giuseppa Sciortino, Domenico Tegolo, Cesare Valenti
In this paper we propose a new methodology to support the physician both to identify automatically the nuchal region and to obtain a correct thickness measurement of the nuchal translucency. The thickness of the nuchal translucency is one of the main markers for screening of chromosomal defects such as trisomy 13, 18 and 21. Its measurement is performed during ultrasound scanning in the first trimester of pregnancy. The proposed methodology is mainly based on wavelet and multi resolution analysis. The performance of our method was analysed on 382 random frames, representing mid-sagittal sections, uniformly extracted from real clinical ultrasound videos of 12 patients...
March 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28125099/a-comparison-of-standard-two-dimensional-ultrasound-to-three-dimensional-volume-sonography-for-routine-second-trimester-fetal-imaging
#17
M E Roy-Lacroix, F Moretti, Z M Ferraro, L Brosseau, J Clancy, K Fung-Kee-Fung
OBJECTIVE: In comparison with standard two-dimensional (2D) imaging of fetal structure and biometry, we aimed to evaluate the role of three-dimensional (3D) imaging as a screening tool in the mid-trimester. STUDY DESIGN: Pregnant women presenting between 18and 22 weeks for routine anatomical survey and biometric measurements were recruited. Six volumes of fetal anatomic regions were obtained and archived for later reconstruction, along with three volumes of extra-fetal structures (placenta, cervix, amniotic fluid)...
January 26, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28063549/insuffisance-cervicale-et-cerclage-cervical
#18
Richard Brown, Robert Gagnon, Marie-France Delisle
OBJECTIF: La présente directive clinique a pour but de fournir un cadre de référence que les cliniciens pourront utiliser pour identifier les femmes qui sont exposées aux plus grands risques de connaître une insuffisance cervicale, ainsi que pour déterminer les circonstances en présence desquelles la mise en place d'un cerclage pourrait s'avérer souhaitable. RéSULTATS: La littérature publiée a été récupérée par l'intermédiaire de recherches menées dans PubMed ou MEDLINE, CINAHL et The Cochrane Library en 2012 au moyen d'un vocabulaire contrôlé (p...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28055026/anterior-uterocervical-angle-measurement-improves-prediction-of-cerclage-failure
#19
J C Knight, E Tenbrink, J Sheng, A S Patil
OBJECTIVE: To compare the anterior uterocervical angle and cervical length as predictors of spontaneous preterm delivery in patients with transvaginal cerclage. STUDY DESIGN: We retrospectively evaluated a cohort of 142 pregnant women with transvaginal cerclage placed over a 5-year period (2010 to 2015) were evaluated. Cervical morphology characteristics were measured from endovaginal imaging, including cervical length, cerclage height, funnel volume and anterior uterocervical angle prior to cerclage placement (UCA 1), shortly after cerclage placement (UCA 2) and the last image prior to delivery (UCA 3)...
January 5, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28009530/maternal-cortisol-during-pregnancy-and-infant-adiposity-a-prospective-investigation
#20
Sonja Entringer, Claudia Buss, Jerod M Rasmussen, Karen Lindsay, Daniel L Gillen, Dan M Cooper, Pathik D Wadhwa
CONTEXT: Glucocorticoids play a key role during intrauterine development in cellular growth and differentiation. Evidence suggests that exposure to inappropriate concentrations of glucocorticoids during sensitive developmental periods may produce alterations in physiological systems that impact obesity risk. OBJECTIVE: To elucidate the magnitude and stage-of-gestation specific association of maternal cortisol concentrations during pregnancy with infant adiposity...
December 23, 2016: Journal of Clinical Endocrinology and Metabolism
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