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https://www.readbyqxmd.com/read/29792247/spontaneous-version-of-fetal-presentation-in-twin-pregnancies-during-third-trimester-longitudinal-assessment
#1
Jeong Woo Park, Seung Mi Lee, Hye-Sim Kang, Soon-Sup Shim, Jong Kwan Jun
Little is known about longitudinal changes of the first twin presentation in twin gestations. This is a retrospective cohort study including 411 women who were admitted consecutively and delivered live-born twins at 36 weeks of gestation or more. Longitudinal assessment of the first twin presentation was conducted during gestation and at birth in all cases. Gestational age at antenatal assessment was divided into two intervals: early-third trimester (28-31 weeks) and mid-third trimester (32-35 weeks). Fetal presentation was categorized as vertex or non-vertex...
June 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29791909/iodine-induced-fetal-hypothyroidism-diagnosis-and-treatment-with-intra-amniotic-levothyroxine
#2
Macy T Hardley, Andrew H Chon, Jorge Mestman, Caroline T Nguyen, Mitchell E Geffner, Ramen H Chmait
BACKGROUND: Iodine is necessary for fetal thyroid development. Excess maternal intake of iodine can cause fetal hypothyroidism due to the inability to escape from the Wolff-Chaikoff effect in utero. CASE REPORT: We report a case of fetal hypothyroid goiter secondary to inadvertent excess maternal iodine ingestion from infertility supplements. The fetus was successfully treated with intra-amniotic levothyroxine injections. Serial fetal blood sampling confirmed fetal escape from the Wolff-Chaikoff effect in the mid third trimester...
May 23, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29786153/vasa-previa-screening-strategies-a-decision-and-cost-effectiveness-analysis
#3
R G Sinkey, A O Odibo
OBJECTIVE: The aim of this study is to perform a decision and cost-effectiveness analysis comparing four screening strategies for the antenatal diagnosis of vasa previa among singleton pregnancies. METHODS: A decision-analytic model was constructed comparing vasa previa screening strategies. Published probabilities and costs were applied to four transvaginal screening scenarios which occurred at the time of mid-trimester ultrasound: no screening, ultrasound-indicated screening, screening pregnancies conceived by in vitro fertilization (IVF), and universal screening...
May 22, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29773978/effects-of-sevoflurane-exposure-during-mid-pregnancy-on-learning-and-memory-in-offspring-rats-beneficial-effects-of-maternal-exercise
#4
Ziyi Wu, Xingyue Li, Yi Zhang, Dongyi Tong, Lili Wang, Ping Zhao
Fetal exposure to general anesthetics may pose significant neurocognitive risks but methods to mitigate against these detrimental effects are still to be determined. We set out, therefore, to assess whether single or repeated in utero exposure to sevoflurane triggers long-term cognitive impairments in rat offspring. Since maternal exercise during pregnancy has been shown to improve cognition in offspring, we hypothesized that maternal treadmill exercise during pregnancy would protect against sevoflurane-induced neurotoxicity...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29754004/natural-disaster-related-prenatal-maternal-stress-is-associated-with-alterations-in-placental-glucocorticoid-system-the-qf2011-queensland-flood-study
#5
Joey St-Pierre, David P Laplante, Guillaume Elgbeili, Paul A Dawson, Sue Kildea, Suzanne King, Cathy Vaillancourt
We investigated the effects of a natural disaster (a sudden flood) as a source of prenatal maternal stress (PNMS) on the placental glucocorticoid system and glucose transporters. Whether the gestational age at the time of the flood moderated these effects was also evaluated. Placental samples were collected from participants in the 2011 Queensland Flood Study (QF2011) who were pregnant in the first or second trimester at the onset of the flood. Detailed questionnaire results for objective hardship and composite subjective distress were obtained to assess stress levels...
April 26, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29747594/the-treatment-of-booking-gestational-diabetes-mellitus-tobogm-pilot-randomised-controlled-trial
#6
David Simmons, Jodie Nema, Chloe Parton, Lisa Vizza, Annette Robertson, Rohit Rajagopal, Jane Ussher, Janette Perz
BACKGROUND: We piloted a randomised controlled trial (RCT) comparing pregnancy outcomes among women with booking gestational diabetes (GDM) receiving immediate or deferred treatment. METHODS: Consecutive, consenting women < 20 weeks gestation, with GDM risk factors attending the hospital book-in clinic, completed an oral glucose tolerance test (OGTT). Clinicians were blinded to OGTT results. Women fulfilling World Health Organisation GDM criteria were randomised to either clinic referral /ongoing treatment (Treated Group n = 11), or no treatment (No Treatment Group n = 10)...
May 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29746604/a-description-of-externally-recorded-womb-sounds-in-human-subjects-during-gestation
#7
Joanna J Parga, Robert Daland, Kalpashri Kesavan, Paul M Macey, Lonnie Zeltzer, Ronald M Harper
OBJECTIVE: Reducing environmental noise benefits premature infants in neonatal intensive care units (NICU), but excessive reduction may lead to sensory deprivation, compromising development. Instead of minimal noise levels, environments that mimic intrauterine soundscapes may facilitate infant development by providing a sound environment reflecting fetal life. This soundscape may support autonomic and emotional development in preterm infants. We aimed to assess the efficacy and feasibility of external non-invasive recordings in pregnant women, endeavoring to capture intra-abdominal or womb sounds during pregnancy with electronic stethoscopes and build a womb sound library to assess sound trends with gestational development...
2018: PloS One
https://www.readbyqxmd.com/read/29740100/genetic-and-environmental-influences-on-fetal-growth-vary-during-sensitive-periods-in-pregnancy
#8
Tsegaselassie Workalemahu, Katherine L Grantz, Jagteshwar Grewal, Cuilin Zhang, Germaine M Buck Louis, Fasil Tekola-Ayele
Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared environment, and genetic correlations of fetal growth measures (abdominal circumference (AC), humerus length (HL), femur length (FL), and estimated fetal weight (EFW)) in a prospective cohort of dichorionic twin gestations recruited through the NICHD Fetal Growth Studies...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738749/the-vaginal-eukaryotic-dna-virome-and-preterm-birth
#9
Kristine M Wylie, Todd N Wylie, Alison G Cahill, George A Macones, Methodius G Tuuli, Molly J Stout
BACKGROUND: Despite decades of attempts to link infectious agents to preterm birth, an exact causative microbe or community of microbes remains elusive. Culture-independent sequencing of vaginal bacterial communities demonstrates community characteristics are associated with preterm birth, although none are specific enough to apply clinically. Viruses are important components of the vaginal microbiome and have dynamic relationships with vaginal bacterial communities. We hypothesized that vaginal eukaryotic DNA viral communities (the "vaginal virome") either alone or in the context of bacterial communities are associated with preterm birth...
May 5, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29734629/air-pollution-exposure-during-pregnancy-and-ultrasound-and-birth-measures-of-fetal-growth-a-prospective-cohort-study-in-korea
#10
Dirga Kumar Lamichhane, Jia Ryu, Jong-Han Leem, Mina Ha, Yun-Chul Hong, Hyesook Park, Yangho Kim, Dal-Young Jung, Ji-Young Lee, Hwan-Cheol Kim, Eun-Hee Ha
Few studies have examined the effects of air pollution on fetal growth based on ultrasound measures during pregnancy. More data is needed to evaluate the windows of special vulnerability. Our aim was to investigate the association of ambient air pollution during pregnancy with fetal and neonatal characteristics in a cohort of Korean women. Maternal exposure to particulate matter with an aerodynamic diameter<10μm (PM10 ) and nitrogen dioxide (NO2 ) was estimated using land-use regression models based on residential address...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29730033/incidence-and-biomarkers-of-pregnancy-spontaneous-abortion-and-neonatal-loss-during-an-environmental-stressor-implications-for-female-reproductive-suppression-in-the-cooperatively-breeding-meerkat
#11
Kristin A Dimac-Stohl, Charli S Davies, Nicholas M Grebe, Alexandra C Stonehill, Lydia K Greene, Jessica Mitchell, Tim Clutton-Brock, Christine M Drea
Meerkats are group-living, insectivorous herpestids in which subordinate members provide extensive care for the dominant female's young. In contrast to some cooperative breeders, subordinate female meerkats are physiologically able to reproduce and occasionally do so successfully; their attempts are more frequently 'suppressed' via eviction or infanticide by the dominant female. Spontaneous abortion and neonatal loss occur with some regularity, further negatively impacting reproductive success. Here, we compared the reproductive outcomes and endocrine profiles, including of serum progesterone (P4 ), serum estradiol (E2 ), and fecal glucocorticoid metabolites (fGCm), of dominant and subordinate dams residing within their clans in the Kalahari Desert of South Africa...
May 2, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29727133/identifying-vulnerable-periods-of-neurotoxicity-to-triclosan-exposure-in-children
#12
Medina S Jackson-Browne, George D Papandonatos, Aimin Chen, Antonia M Calafat, Kimberly Yolton, Bruce P Lanphear, Joseph M Braun
BACKGROUND: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment. OBJECTIVE: Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study. METHODS: We quantified triclosan in urine samples from mother-child pairs up to nine times between the second trimester of gestation and 8 y of age...
May 2, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29679053/pregnancy-associated-diamine-oxidase-originates-from-extravillous-trophoblasts-and-is-decreased-in-early-onset-preeclampsia
#13
Philipp Velicky, Karin Windsperger, Karin Petroczi, Sophie Pils, Birgit Reiter, Tamara Weiss, Sigrid Vondra, Robin Ristl, Sabine Dekan, Christian Fiala, David E Cantonwine, Thomas F McElrath, Bernd Jilma, Martin Knöfler, Thomas Boehm, Jürgen Pollheimer
Human extravillous trophoblast (EVT) invasion of the pregnant uterus constitutes a pivotal event for the establishment of the maternal-fetal interface. Compromised EVT function manifesting in inadequate arterial remodeling is associated with the severe pregnancy disorder early-onset preeclampsia (eoPE). Recent studies suggest that EVTs invade the entire uterine vasculature including arteries, veins and lymphatics in the first trimester of pregnancy. We therefore hypothesized that EVT-derived factors accumulate in the circulation of pregnant women early in gestation and may serve to predict eoPE...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29675495/maternal-history-and-uterine-artery-wave-form-in-the-prediction-of-early-onset-and-late-onset-preeclampsia-a-cohort-study
#14
Nidhi Sharma, Krishnamurthy Jayashree, Kulasekaran Nadhamuni
Background: Pregnancy induced hypertension (PIH) is a significant cause of maternal morbidity and mortality. Pregnancy-induced-hypertension can be prevented by identification of prenatal and antenatal factors. The uterine artery Doppler waveform transforms into a high flow with low resistance at 22-24 wk. Objective: To study the maternal risk factors and uterine artery Doppler waveform in singleton mid-trimester pregnancy and predict the occurrence of pregnancy-induced hypertension ...
February 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29668689/association-between-particulate-air-pollution-exposure-during-pregnancy-and-postpartum-maternal-psychological-functioning
#15
Perry E Sheffield, Rosa Speranza, Yueh-Hsiu Mathilda Chiu, Hsiao-Hsien Leon Hsu, Paul C Curtin, Stefano Renzetti, Ashley Pajak, Brent Coull, Joel Schwartz, Itai Kloog, Rosalind J Wright
METHODS: We studied associations between prenatal exposure to particulate matter with diameter ≤ 2.5 μm (PM2.5) and postpartum psychological functioning in a lower income, ethnically mixed sample of urban US women enrolled in a pregnancy cohort study. Analyses included 557 mothers who delivered at ≥37 weeks gestation. Daily estimates of residential PM2.5 over gestation were derived using a satellite-based spatio-temporally resolved model. Outcomes included the Edinburgh Postnatal Depression Scale (EPDS) score from 6 or 12 months postpartum and subscale scores for anhedonia, depressive and anxiety symptoms...
2018: PloS One
https://www.readbyqxmd.com/read/29665872/maternal-intake-of-omega-3-and-omega-6-polyunsaturated-fatty-acids-during-mid-pregnancy-is-inversely-associated-with-linear-growth
#16
M Al-Hinai, A Baylin, M M Tellez-Rojo, A Cantoral, A Ettinger, M Solano-González, K E Peterson, W Perng
This study investigates relations of maternal N-3 and N-6 polyunsaturated fatty acids (PUFA) intake during pregnancy with offspring body mass index (BMI), height z-score and metabolic risk (fasting glucose, C-peptide, leptin, lipid profile) during peripuberty (8-14 years) among 236 mother-child pairs in Mexico. We used food frequency questionnaire data to quantify trimester-specific intake of N-3 alpha-linolenic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); N-6 linoleic acid and arachidonic acid (AA); and N-6:N-3 (AA:EPA+DHA), which accounts for the fact that the two PUFA families have opposing effects on physiology...
April 18, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29665089/three-dimensional-endoanal-ultrasound-features-of-the-anal-sphincter-in-asian-primigravidae
#17
Dakshitha Praneeth Wickramasinghe, Supun Senaratne, Hemantha Senanayake, Dharmabandu Nandadeva Samarasekera
OBJECTIVES: The normal parameters of 3-dimensional endoanal ultrasound (3DEAUS) of the anal sphincter have not been reported for primigravidae or pregnant women at present. 3DEAUS parameters in Asian primigravidae were assessed in this study. METHODS: We analyzed 3DEAUS data of 101 consecutives Asian primigravidae, assessed in the early third trimester. The assessment was performed with a rigid ultrasonic probe (Olympus® RU 12M-R1 probe and EU-ME1 ultrasound system (Olympus Corp...
April 17, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29626976/chronic-histiocytic-intervillositis-clinical-biochemical-and-radiological-findings-an-observational-study
#18
Lawrence Koby, Sarah Keating, Ann Kinga Malinowski, Rohan D'Souza
INTRODUCTION: Chronic histiocytic intervillositis (CHI) of the placenta although rare, has a high recurrence rate, is associated with serious adverse pregnancy outcomes and has no available treatment. This study aims to determine clinical, biochemical and radiological factors associated with CHI, to guide management of subsequent pregnancies. METHODS: This retrospective observational study included consecutive cases with a histopathologic diagnosis of CHI after 18 weeks of gestation, between 2001 and 2014, and no controls...
April 2018: Placenta
https://www.readbyqxmd.com/read/29616236/effects-of-water-quality-sanitation-handwashing-and-nutritional-interventions-on-child-development-in-rural-kenya-wash-benefits-kenya-a-cluster-randomised-controlled-trial
#19
Christine P Stewart, Patricia Kariger, Lia Fernald, Amy J Pickering, Charles D Arnold, Benjamin F Arnold, Alan E Hubbard, Holly N Dentz, Audrie Lin, Theodora J Meerkerk, Erin Milner, Jenna Swarthout, John M Colford, Clair Null
Background: Poor nutrition and infectious diseases can prevent children from reaching their developmental potential. We aimed to assess the effects of improvements in water, sanitation, handwashing, and nutrition on early child development in rural Kenya. Methods: In this cluster-randomised controlled trial, we enrolled pregnant women in their second or third trimester from three counties (Kakamega, Bungoma, and Vihiga) in Kenya's western region, with an average of 12 households per cluster...
April 2018: Lancet Child & Adolescent Health
https://www.readbyqxmd.com/read/29593656/serum-phthalate-and-triclosan-levels-have-opposing-associations-with-risk-factors-for-gestational-diabetes-mellitus
#20
Benjamin G Fisher, Hanne Frederiksen, Anna-Maria Andersson, Anders Juul, Ajay Thankamony, Ken K Ong, David B Dunger, Ieuan A Hughes, Carlo L Acerini
Certain phthalates and bisphenol A (BPA) have been associated with insulin resistance and type 2 diabetes in non-pregnant adults, but studies of gestational diabetes mellitus (GDM) have reported conflicting results for phthalates and no associations with BPA. Our aim was to investigate the relationship between maternal serum levels of phthalate metabolites and phenols at 10-17 weeks of gestation and glucose homeostasis at 28 weeks of gestation. 232 women aged ≥16 years without type 1 or 2 diabetes with singleton male pregnancies were recruited from a single UK maternity centre between 2001 and 2009 as part of a prospective observational study (Cambridge Baby Growth Study)...
2018: Frontiers in Endocrinology
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