Robert J Mentz, Susanna R Stevens, Adam D DeVore, Anuradha Lala, Justin M Vader, Omar F AbouEzzeddine, Prateeti Khazanie, Margaret M Redfield, Lynne W Stevenson, Christopher M O'Connor, Steven R Goldsmith, Bradley A Bart, Kevin J Anstrom, Adrian F Hernandez, Eugene Braunwald, G Michael Felker
OBJECTIVES: The purpose of this study was to assess the relationship between biomarkers of renin-angiotensin-aldosterone system (RAAS) activation and decongestion strategies, worsening renal function, and clinical outcomes. BACKGROUND: High-dose diuretic therapy in patients with acute heart failure (AHF) is thought to activate the RAAS; and alternative decongestion strategies, such as ultrafiltration (UF), have been proposed to mitigate this RAAS activation. METHODS: This study analyzed 427 AHF patients enrolled in the DOSE-AHF (Diuretic Optimization Strategies in Acute Heart Failure) and CARRESS-HF (Cardiorenal Rescue Study in Acute Decompensated Heart Failure) trials...
February 2015: JACC. Heart Failure