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iron ferritin hypertriglyceridemia

Rocío Mateo-Gallego, Laura Lacalle, Sofía Pérez-Calahorra, Victoria Marco-Benedí, Valle Recasens, Noelia Padrón, Itziar Lamiquiz-Moneo, Lucía Baila-Rueda, Estíbaliz Jarauta, Pilar Calmarza, Ana Cenarro, Fernando Civeira
BACKGROUND: High ferritin concentration is associated with hypertriglyceridemia, although it is not elucidated if iron overload has a causal role. OBJECTIVE: To evaluate the efficacy of repeated phlebotomies in patients with iron overload and hypertriglyceridemia. METHODS: Twelve weeks, 1:1 randomized, parallel-groups trial conducted at a University Hospital Lipid Clinic, including 86 subjects aged 18-70 years with serum ferritin >300 ng/mL in men or >200 ng/mL in women and triglycerides >200 mg/dL...
July 4, 2018: Journal of Clinical Lipidology
Marin Golčić, Marija Petković
Metastatic renal cell carcinoma (mRCC) develops in approximately 33% of all renal cancer patients. First line treatment of mRCC includes drugs such as sunitinib, temsirolimus and pazopanib, with overall survival now reaching up to 43,6months in patients with favorable-risk metastatic disease. Several side-effects in mRCC treatment, such as hypothyroidism, can be used as positive prognostic factors and indicate good response to therapy. Hypercholesterolemia and hypertriglyceridemia independent of hypothyroidism are reported as side-effects in temsirolimus treatment and recently in sunitinib treatment, but the exact mechanism and significance of the changes remains elusive...
September 2016: Medical Hypotheses
Po-Chun Ko, Shih-Yi Huang, Ching-Hung Hsieh, Ming-I Hsu, Chun-Sen Hsu
OBJECTIVE: The aim of this study is to evaluate serum ferritin levels and polycystic ovary syndrome (PCOS)-related complications in obese and nonobese women. MATERIALS AND METHODS: This retrospective study included 539 (286 with PCOS and 253 without PCOS). RESULTS: Serum ferritin correlated with menstrual cycle length, sex hormone-binding globulin, total testosterone, androstenedione, triglyceride, and total cholesterol in both obese and nonobese women...
August 2015: Taiwanese Journal of Obstetrics & Gynecology
Marta Ledesma, Yamilee Hurtado-Roca, Montserrat Leon, Pilar Giraldo, Miguel Pocovi, Fernando Civeira, Eliseo Guallar, Jose Maria Ordovas, Jose Antonio Casasnovas, Martin Laclaustra
CONTEXT: Ferritin concentration is associated with metabolic syndrome, but the possibility of a nonlinear association has never been explored. OBJECTIVE: This study aimed to examine the relationship between serum ferritin levels and the metabolic syndrome in Spanish adult males. DESIGN: This was a cross-sectional analysis of baseline data from the Aragon Workers' Health Study. SETTING: Healthy workers from a factory were studied during their annual checkup...
May 2015: Journal of Clinical Endocrinology and Metabolism
Paola Casanova-Esteban, Nuria Guiral, Eva Andrés, Carmen Gonzalvo, Rocio Mateo-Gallego, Pilar Giraldo, Jose A Paramo, Fernando Civeira
Genetic predisposition to hereditary hemochromatosis (HH) is associated with primary hypertriglyceridemia (HTG). If iron overload influences the development of HTG, the management of these patients could be different. However, the metabolic syndrome in primary HTG is frequent; and it could partially confuse the association. The objective was to determine whether periodic bloodletting could decrease triglyceride concentrations in subjects with HH and iron overload. We retrospectively studied 155 genetically defined HH patients (C282Y homozygotes and compound heterozygotes C282Y/H63D) with iron overload and under periodic therapeutic phlebotomy...
June 2011: Metabolism: Clinical and Experimental
Rocio Mateo-Gallego, Maria Solanas-Barca, Elena Burillo, Ana Cenarro, Iva Marques-Lopes, Fernando Civeira
Iron deposits are associated with lipid phenotype in familial hypertriglyceridemias, mainly familial combined hyperlipidemia (FCH) and familial hypertriglyceridemia (FHTG). In turn, diet plays an important role in hypertriglyceridemias although it is not known if dietary patterns are associated with iron concentration in these disorders. The objective was to determine the relationship between diet and iron deposits, measured through serum ferritin concentration, in patients with FCH and FHTG. The study was composed of 140 patients, 107 with FCH and 33 with FHTG...
September 2010: Journal of Physiology and Biochemistry
Rocio Mateo-Gallego, Pilar Calmarza, Estibaliz Jarauta, Elena Burillo, Ana Cenarro, Fernando Civeira
Familial combined hyperlipidemia (FCH) and familial hypertriglyceridemia (FHTG) share pathogenic mechanisms and a high interaction with components of the metabolic syndrome. The metabolic syndrome associates increased serum ferritin concentration and high cardiovascular risk. The objective was to describe the frequency of iron overload and the relationship between serum ferritin and the phenotype in patients with FCH and FHTG. The study was composed of 211 consecutive unrelated patients aged at least 18 years with primary hypertriglyceridemia, 149 with FCH, and 62 with FHTG...
February 2010: Metabolism: Clinical and Experimental
Istvan S Vari, Beverley Balkau, Adrian Kettaneh, Philippe André, Jean Tichet, Frédéric Fumeron, Emile Caces, Michel Marre, Bernard Grandchamp, Pierre Ducimetière
OBJECTIVE: The aim of this work was to study cross-sectional and longitudinal relations between iron stocks (ferritin) and the iron transport protein (transferrin) with the metabolic syndrome and its abnormalities. RESEARCH DESIGN AND METHODS: A total of 469 men and 278 premenopausal and 197 postmenopausal women from the French Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort, aged 30-65 years, were followed over 6 years. RESULTS: Higher concentrations of both ferritin and transferrin were associated with the International Diabetes Federation (IDF) and the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Adult Treatment Panel III original and revised definitions of the metabolic syndrome at baseline: for the IDF definition of the metabolic syndrome, the standardized, age-adjusted odds ratios (95% CI) for log(ferritin) were 1...
July 2007: Diabetes Care
F Pérez-Aguilar, S Benlloch, M Berenguer
OBJECTIVE: To determine the etiology of increased ferritin concentrations and/or transferrin saturation in patients in whom classical causes were ruled out. PATIENTS AND METHOD: We studied 43 patients (35 males and 8 females) who were referred for ferritinemia greater than 300 ng/ml and or a transferrin saturation index (TSI) greater than 40%. In all patients, glycemia, cholesterol, triglycerides, uric acid, total and fractionated bilirubin, transaminase, gammaglutamyltranspeptidase, sideremia, TSI, ferritin, HFE gene mutations, ceruloplasmin and total 24-hour urine porphyrin were evaluated and abdominal ultrasonography was performed...
November 2004: Gastroenterología y Hepatología
M T Barrellier, P Carpentier, J P Henriet, A Lequerrec, J Derlon, M C Khayat, L Agron, P Letellier
Etiology of deep vein thrombosis in ambulant patients (DVTA = TVPA in text) varies: cancer, blood disease, infectious focus, dysimmunity syndrome, dysglobulinemia, extrinsic compression, metabolic disorder, anomaly of hemostasis. A prospective study was carried out between June 1988 and September 1989 by angiologists in 5 regions of France to evaluate the diagnostic rentability of an epidemiologic survey and to determine possible distinctive characters of DVTA. The survey was comprised of a questionnaire, a full clinical examination and screening tests: chest x-ray, abdominopelvic ultrasound imaging, a-uro/gynecologic examination, full blood count, serum iron, ferritin, uric acid, triglycerides, cholesterol, protein electrophoresis, antinuclear antibodies, circulating anticoagulant, hemostasis factors and liver function tests...
1992: Journal des Maladies Vasculaires
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