keyword
https://read.qxmd.com/read/38512048/recent-advances-in-current-uptake-situation-metabolic-and-nutritional-characteristics-health-and-safety-of-dietary-tryptophan
#21
REVIEW
Haoyan Zhu, Xingbin Yang, Yan Zhao
Tryptophan (Trp) is an essential amino acid which is unable to be synthesized in the body. Main sources of Trp are uptake of foods such as oats and bananas. In this review, we describe the status of current dietary consumption, metabolic pathways and nutritional characteristics of Trp, as well as its ingestion and downstream metabolites for maintaining body health and safety. This review also summarizes the recent advances in Trp metabolism, particularly the 5-HT, KYN, and AhR activation pathways, revealing that its endogenous host metabolites are not only differentially affected in the body but also are closely linked to health...
March 21, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38509755/ccdc157-is-essential-for-sperm-differentiation-and-shows-oligoasthenoteratozoospermia-related-mutations-in-men
#22
JOURNAL ARTICLE
Huimei Zheng, Chenjia Gong, Jingping Li, Jiaru Hou, Xinhan Gong, Xinhai Zhu, Huan Deng, Haoyue Wu, Fengbin Zhang, Qinghua Shi, Jianteng Zhou, Baolu Shi, Xiaohang Yang, Yongmei Xi
Oligoasthenoteratospermia (OAT), characterized by abnormally low sperm count, poor sperm motility, and abnormally high number of deformed spermatozoa, is an important cause of male infertility. Its genetic basis in many affected individuals remains unknown. Here, we found that CCDC157 variants are associated with OAT. In two cohorts, a 21-bp (g.30768132_30768152del21) and/or 24-bp (g.30772543_30772566del24) deletion of CCDC157 were identified in five sporadic OAT patients, and 2 cases within one pedigree. In a mouse model, loss of Ccdc157 led to male sterility with OAT-like phenotypes...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38508551/augmenting-the-quality-and-storage-stability-of-soymilk-by-incorporation-of-untreated-and-ozonated-oat-1-4-%C3%AE-d-glucan
#23
JOURNAL ARTICLE
Prabhjot Kaur, Kamaljit Kaur, Jaspreet Kaur, Shaik Jakeer Basha, John F Kennedy
The study aimed to improve the quality and storage stability of novel plant-based soymilk with the incorporation of untreated (UtβG) and modified oat derived 1,4-β-D-glucan (OzβG) at varying concentrations (0, 1, and 2 % labelled as S0 , S1 and S2 ). The treated soymilk was characterized for physical, chemical, nutritional, rheological, particle size, zeta potential, sensory and storage stability characteristics. The results revealed that 1, 4-β-D-glucan incorporation increased the acidity (0...
March 18, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38503674/gender-affirming-voice-training-for-trans-women-acoustic-outcomes-and-their-associations-with-listener-perceptions-related-to-gender
#24
JOURNAL ARTICLE
Maria Södersten, Jennifer Oates, Anders Sand, Svante Granqvist, Sterling Quinn, Georgia Dacakis, Ulrika Nygren
OBJECTIVES: To investigate acoustic outcomes of gender-affirming voice training for trans women wanting to develop a female sounding voice and to describe what happens acoustically when male sounding voices become more female sounding. STUDY DESIGN: Prospective treatment study with repeated measures. METHODS: N = 74 trans women completed a voice training program of 8-12 sessions and had their voices audio recorded twice before and twice after training...
March 18, 2024: Journal of Voice
https://read.qxmd.com/read/38502353/piloting-a-language-translation-device-for-mandarin-speaking-patients-presenting-for-radiotherapy-treatment-assessing-patient-and-radiation-therapist-perspectives
#25
JOURNAL ARTICLE
Darren Hunter, Nigel Anderson, Richard Oates, David Kok, Daniel Sapkaroski, Nicola Treffry, Caroline Wright
PURPOSE: Culturally and linguistically diverse (CALD) cancer patients report unmet informational and emotional needs when receiving radiotherapy (RT). This feasibility study aimed to evaluate the clinical use of an instant translation device (ITD) to facilitate communication between Mandarin-speaking patients and radiation therapists (RTTs) within the Australian public RT setting. The primary aim was to assess the ability to convey information relating to daily patient care and build rapport using the device...
March 19, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38501834/-bioactive-components-of-whole-grain-and-their-effect-on-health
#26
JOURNAL ARTICLE
Luis Valladares, Fernando Vio Del Río
Non-communicable diseases represent a global health burden with increasing prevalence. To prevent or improve this type of diseases, dietary strategies based on healthy foods have been suggested. Cereals are the most consumed foods in the world and preventive effects of whole grains on health have been described. The germ and bran of cereals are abundant in bioactive compounds, including phytochemicals, vitamins, minerals and fibers, and these compounds are effective in preventing and improving non-communicable diseases...
March 14, 2024: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/38500434/-progress-in-surgical-treatment-of-osteochondral-lesion-of-talus
#27
JOURNAL ARTICLE
Ning Jiang, Guijun Xu, Haomin Li, Jinming Yang, Jia Wang, Lin Shen, Xiantie Zeng
OBJECTIVE: To provide a comprehensive overview of the surgical treatments of osteochondral lesion of talus (OLT) and offer valuable insights for clinical practice. METHODS: The advantages and limitations of surgical treatments for OLT were comprehensively summarized through an extensive review of domestic and abroad relevant literature in recent years. RESULTS: Currently, there exist numerous surgical treatments for the OLT, all of which can yield favorable outcomes...
March 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/38500209/the-acute-effect-of-a-%C3%AE-glucan-enriched-oat-bread-on-gastric-emptying-glp-1-response-and-postprandial%C3%A2-glycaemia-and-insulinemia-a-randomised-crossover-trial-in-healthy-adults
#28
JOURNAL ARTICLE
Ingrid Revheim, Simon Ballance, Adelheid Fretland Standal, Anne Rieder, Jutta Dierkes, Anette E Buyken, Odd Helge Gilja, Trygve Hausken, Hanne Rosendahl-Riise
BACKGROUND: The cereal fibre β-glucan reduces postprandial glycaemia, however, the underlying mechanisms are not fully understood. Thus, the aim of this study was to investigate the acute effect of a β-glucan-enriched oat bread on gastric emptying half-time (T1/2 ), gastric emptying lag phase (Tlag ), and gastric emptying rate (GER), and the secretion of glucagon-like peptide-1 (GLP-1) as potential means to influence postprandial glycaemia. METHODS: A randomised crossover trial was conducted in 22 healthy adults (age 24...
March 18, 2024: Nutrition & Metabolism
https://read.qxmd.com/read/38498988/molecular-analysis-of-parthenogenetic-chimerism-in-a-46-xx-46-xy-patient-with-idiopathic-oligoasthenoteratozoospermia-oat
#29
Yunjie He, Yuying Yan, Yuanyuan Lv, Jian Zeng
Introduction Parthenogenetic chimera is an extremely rare condition in human. Very few patients with parthenogenetic chimerism with XX/XY cells have been identified. Case Presentation We report the clinical findings and molecular analysis of chimerism with a 46,XX/46,XY karyotype in a patient presenting idiopathic oligoasthenoteratozoospermia (OAT). To clarify the mechanism of chimera formation, short tandem repeat (STR) analysis using 21 loci was carried out. Quantitation of alleles in D6S1043, D12S391, fibrinogen alpha chain (FGA) and Amelogenin revealed double paternal and one maternal genetic contribution to the patient, which is consistent with a parthenogenetic chimerism...
March 18, 2024: Cytogenetic and Genome Research
https://read.qxmd.com/read/38498573/genome-biology-and-evolution-of-mating-type-loci-in-four-cereal-rust-fungi
#30
JOURNAL ARTICLE
Zhenyan Luo, Alistair McTaggart, Benjamin Schwessinger
Permanent heterozygous loci, such as sex- or mating-compatibility regions, often display suppression of recombination and signals of genomic degeneration. In Basidiomycota, two distinct loci confer mating compatibility. These loci encode homeodomain (HD) transcription factors and pheromone receptor (Pra)-ligand allele pairs. To date, an analysis of genome level mating-type (MAT) loci is lacking for obligate biotrophic basidiomycetes in the Pucciniales, an order containing serious agricultural plant pathogens...
March 18, 2024: PLoS Genetics
https://read.qxmd.com/read/38493821/extraction-purification-structural-characteristics-bioactivity-and-potential-applications-of-polysaccharides-from-avena-sativa-l-a-review
#31
REVIEW
Dan Li, Mengjie Chen, Xianwei Meng, Yuan Sun, Rui Liu, Tiedong Sun
Avena sativa L. (A. sativa L.), commonly known as oat, is a significant cereal grain crop with excellent edible and medicinal value. Oat polysaccharides (OPs), the major bioactive components of A. sativa L., have received considerable attention due to their beneficial bioactivities. However, the isolation and purification methods of OPs lack innovation, and the structure-activity relationship remains unexplored. This review emphatically summarized recent progress in the extraction and purification methods, structural characteristics, biological activities, structure-to-function associations and the potential application status of OPs...
March 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38493163/simultaneous-determination-of-bromoxynil-and-mcpa-in-commercial-samples-and-raw-materials-using-reversed-phase-high-performance-liquid-chromatography
#32
JOURNAL ARTICLE
Ahmed Yar, Tariq Mahmood Ansari, Faariah Rehman, Asad Raza, Umair Riaz, Rashid Iqbal, Amal M Al-Mohaimeed, Wedad A Al-Onazi, Muhammad Rizwan
This study encompasses a quick, efficient, repeatable and reproducible analytical method for simultaneous determination of Bromoxynil (3, 5-Dibromo-4-hydroxybenzonitrile) and MCPA (2-methyl-4-chlorophenoxyacetic acid) using RP-HPLC with UV-Detector. Bromoxynil + MCPA is one of the most selective post emergent herbicide formulations for the control of important broad leaf weeds infesting small grains (wheat, barley, oats, rye), conservation reserve program areas and grass grown for seed. Optimum weed control is achieved when Bromoxynil + MCPA is applied to actively growing weed seedlings...
March 16, 2024: BMC chemistry
https://read.qxmd.com/read/38492693/solubilization-and-structural-changes-of-lignin-in-naked-oat-stems-during-subcritical-water-autohydrolysis
#33
JOURNAL ARTICLE
Long Jiang, Yanchen Zhu, Jiahui Wei, Hao Ren, Huamin Zhai
In this study, the solubilization and structural changes of lignin in naked oat stems were investigated under subcritical water autohydrolysis systems (170-210 °C, 0.68-1.85 MPa). In this system, Hemicellulose was preferentially hydrolyzed in the liquid water at elevated temperatures, leading to the production of acetic acid and glucuronic acid, which acidified the reaction system. Under acidic and high-temperature conditions, lignin primarily underwent degradation and condensation reactions...
March 14, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38487179/role-of-tailored-sourdough-fermentation-in-the-flavor-of-wholegrain-oat-bread
#34
JOURNAL ARTICLE
Silvia Cera, Fabio Tuccillo, Antti Knaapila, Finlay Sim, Jessica Manngård, Katariina Niklander, Michela Verni, Carlo Giuseppe Rizzello, Kati Katina, Rossana Coda
Sourdough technology has been known for its role in the improvement of texture, flavor, and quality of mainly wheat and rye-based breads for decades. However, little is reported about its use in the improvement of whole-grain oat bread, especially concerning flavor formation, which is one major consumer drivers. This study investigated the effects of sourdough obtained by different lactic acid bacteria and yeast starters consortia on the texture and flavor of 100% oat bread. Four different consortia were selected to obtain four oat sourdoughs, which were analyzed to assess the main features due to the different starter fermentation metabolism...
2024: Current research in food science
https://read.qxmd.com/read/38486205/role-of-beta-1%C3%A2-3-1%C3%A2-6-d-glucan-derived-from-yeast-on-natural-killer-nk-cells-and-breast-cancer-cell-lines-in-2d-and-3d-cultures
#35
JOURNAL ARTICLE
Abdelhadi Boulifa, Martin J Raftery, Alexander Sebastian Franzén, Clarissa Radecke, Sebastian Stintzing, Jens-Uwe Blohmer, Gabriele Pecher
BACKGROUND: Beta-(1,3)(1,6)-D-glucan is a complex polysaccharide, which is found in the cell wall of various fungi, yeasts, bacteria, algae, barley, and oats and has immunomodulatory, anticancer and antiviral effects. In the present study, we investigated the effect of beta-(1,3)(1,6)-D-glucan derived from yeast on the proliferation of primary NK cells and breast cancer cell lines in 2D and 3D models, and on the cytotoxicity of primary NK cells against breast cancer cell lines in 2D and 3D models...
March 14, 2024: BMC Cancer
https://read.qxmd.com/read/38485280/pharmacokinetic-effects-of-different-models-of-nonalcoholic-fatty-liver-disease-in-transgenic-humanized-oatp1b-mice
#36
JOURNAL ARTICLE
Baron J Bechtold, Katherine D Lynch, Victoria O Oyanna, M Ridge Call, Laura A White, Tyler N Graf, Nicholas H Oberlies, John D Clarke
Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 (collectively, OATP1B) transporters encoded by the solute carrier organic anion transporter ( SLCO) genes mediate uptake of multiple pharmaceutical compounds. Nonalcoholic steatohepatitis (NASH), a severe form of nonalcoholic fatty liver disease (NAFLD), decreases OATP1B abundance. This research characterized the pathological and pharmacokinetics effects of three diet- and one chemical-induced NAFLD model in male and female humanized OATP1B mice, which comprises knock-out of rodent Oatp orthologs and insertion of human SLCO1B1 and SLCO1B3...
March 14, 2024: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://read.qxmd.com/read/38478749/exploring-online-communication-in-self-identified-autistic-adolescents
#37
JOURNAL ARTICLE
Morgan Oates, Rebecca McCauley, Allison Bean
PURPOSE: Social media sites provide autistic youth a familiar space to interact that is devoid of many of the challenges that accompany face-to-face interactions. As such, it is important to determine whether the linguistic profiles observed during online interactions are consistent with face-to-face interactions. This preliminary study took a step in this direction by examining gender differences observed in autistic adolescents in an online forum to determine whether they are consistent with the emerging body of research investigating linguistic gender differences in autistic adolescents...
March 13, 2024: Journal of Speech, Language, and Hearing Research: JSLHR
https://read.qxmd.com/read/38478290/complexity-of-chemical-emissions-increases-concurrently-with-sexual-maturity-in-heliconius-butterflies
#38
JOURNAL ARTICLE
Bruna Cama, Karl Heaton, Jane Thomas-Oates, Stefan Schulz, Kanchon K Dasmahapatra
Pheromone communication is widespread among animals. Since it is often involved in mate choice, pheromone production is often tightly controlled. Although male sex pheromones (MSPs) and anti-aphrodisiacs have been studied in some Heliconius butterfly species, little is known about the factors affecting their production and release in these long-lived butterflies. Here, we investigate the effect of post-eclosion age on chemical blends from pheromone-emitting tissues in Heliconius atthis and Heliconius charithonia, exhibiting respectively free-mating and pupal-mating strategies that are hypothesised to differently affect the timing of their pheromone emissions...
March 13, 2024: Journal of Chemical Ecology
https://read.qxmd.com/read/38477808/3d-modeling-from-hip-dxa-shows-improved-bone-structure-with-romosozumab-followed-by-denosumab-or-alendronate
#39
JOURNAL ARTICLE
E Michael Lewiecki, Donald Betah, Ludovic Humbert, Cesar Libanati, Mary Oates, Yifei Shi, Renaud Winzenrieth, Serge Ferrari, Fumitoshi Omura
Romosozumab treatment in women with postmenopausal osteoporosis increases bone formation while decreasing bone resorption, resulting in large BMD gains to reduce fracture risk within 1 year. DXA-based 3D modeling of the hip was used to assess estimated changes in cortical and trabecular bone parameters and map the distribution of 3D changes in bone parameters over time in patients from two randomized controlled clinical trials: FRAME (romosozumab vs placebo followed by denosumab) and ARCH (romosozumab vs alendronate followed by alendronate)...
February 15, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38477431/enhanced-reactivities-of-iron-iv-oxo-porphyrin-species-in-oxidation-reactions-promoted-by-intramolecular-hydrogen-bonding
#40
JOURNAL ARTICLE
Zhe Gong, Liwei Wang, Yiran Xu, Duanfeng Xie, Xiaotian Qi, Wonwoo Nam, Mian Guo
High-valent iron-oxo species are one of the common intermediates in both biological and biomimetic catalytic oxidation reactions. Recently, hydrogen-bonding (H-bonding) has been proved to be critical in determining the selectivity and reactivity. However, few examples have been established for mechanistic insights into the H-bonding effect. Moreover, intramolecular H-bonding effect on both C-H activation and oxygen atom transfer (OAT) reactions in synthetic porphyrin model system has not been investigated yet...
March 13, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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