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https://www.readbyqxmd.com/read/29450643/variants-in-fix-propeptide-associated-with-vitamin-k-antagonist-hypersensitivity-functional-analysis-and-additional-data-confirming-the-common-founder-mutations
#1
Behnaz Pezeshkpoor, Katrin J Czogalla, Michael Caspers, Ann-Cristin Berkemeier, Kerstin Liphardt, Suvoshree Ghosh, Marco Kellner, Silvia Ulrich, Anna Pavlova, Johannes Oldenburg
One of the most common and unwanted side effects during oral anticoagulant therapy (OAT) is bleeding complications. In rare cases, vitamin K antagonist (VKA)-related bleeding events are associated with mutations affecting the F9 propeptide at amino acid position 37 due to a substitution of alanine to either valine or threonine. Based on our actual cohort of 18 patients, we update the knowledge on this rare phenotype and its origin. A founder mutation for both variants was reconfirmed by haplotype analysis of intronic and extragenic short tandem repeat (STR) polymorphisms with a higher prevalence in Switzerland than in other regions of Europe...
February 15, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29448871/interactions-of-organophosphorus-pesticides-with-solute-carrier-slc-drug-transporters
#2
Lisa Chedik, Arnaud Bruyere, Olivier Fardel
1. Organophosphorus pesticides (OPs) are known to interact with human ATP-binding cassette drug efflux pumps. The present study was designed to determine whether they can also target activities of human solute carrier (SLC) drug transporters. 2. The interactions of thirteen OPs with SLC transporters involved in drug disposition, such as organic cation transporters (OCTs), multidrug and toxin extrusion proteins (MATEs), organic anion transporters (OATs) and organic anion transporting polypeptides (OATPs), were mainly investigated using transporter-overexpressing cell clones and fluorescent or radiolabeled reference substrates...
February 16, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29447177/physician-prescribing-of-opioid-agonist-treatments-in-provincial-correctional-facilities-in-ontario-canada-a-survey
#3
Fiona G Kouyoumdjian, Alexandra Patel, Matthew J To, Lori Kiefer, Leonora Regenstreif
BACKGROUND: Substance use and substance use disorders are common in people who experience detention or incarceration in Canada, and opioid agonist treatment (OAT) may reduce the harms associated with substance use disorders. We aimed to define current physician practice in provincial correctional facilities in Ontario with respect to prescribing OAT and to identify potential barriers and facilitators to prescribing OAT. METHODS: We invited all physicians practicing in the 26 provincial correctional facilities for adults in Ontario to participate in an online survey...
2018: PloS One
https://www.readbyqxmd.com/read/29446518/interwoven-histories-mental-health-nurses-with-experience-of-mental-illness-qualitative-findings-from-a-mixed-methods-study
#4
Jennifer Oates, Nicholas Drey, Julia Jones
The effects of mental health nurses' own experience of mental illness or being a carer have rarely been researched beyond the workplace setting. This study aimed to explore how the experience of mental illness affects mental health nurses' lives outside of and inside work. A sample of 26 mental health nurses with personal experience of mental illness took part in semistructured interviews. Data were analysed thematically using a six-phase approach. The analysis revealed the broad context of nurses' experiences of mental illness according to three interwoven themes: mental illness as part of family life; experience of accessing services; and life interwoven with mental illness...
February 15, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29444734/growth-performance-carcass-and-noncarcass-traits-and-meat-quality-of-barbarine-lambs-fed-rosemary-distillation-residues
#5
Y Yagoubi, H Hajji, S Smeti, M Mahouachi, M Kamoun, N Atti
The aim of this experiment was to study the effect of total replacement of oat hay by rosemary distillation residues (RR) on growth, carcass characteristics and meat quality of Barbarine lambs. A total of 21 lambs were divided into three groups. The control group (C) was offered 600 g of oat hay; the RR87 and RR60 groups received 600 g of pellets containing 87% and 60% of RR, respectively. The CP content was 9% and 14% for RR87 and RR60, respectively. All animals were supplemented by 600 g of concentrate. After 77 days of fattening, lambs were slaughtered...
February 15, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29444228/towards-optimal-electronic-medical-record-use-perspectives-of-advanced-users
#6
Amanda L Terry, Bridget L Ryan, Scott McKay, Michael Oates, Jill Strong, Kate McRobert, Amardeep Thind
Background: While primary health care electronic medical record (EMR) adoption has increased in Canada, the use of advanced EMR features is limited. Realizing the potential benefits of primary health care EMR use is dependent not only on EMR acquisition, but also on its comprehensive use and integration into practice; yet, little is known about the advanced use of EMRs in primary health care. Objective: To explore the views of advanced primary health care EMR users practising in a team-based environment...
February 10, 2018: Family Practice
https://www.readbyqxmd.com/read/29443904/comparison-of-conventional-and-microwave-assisted-heating-on-carbohydrate-content-antioxidant-capacity-and-postprandial-glycemic-response-in-oat-meals
#7
Joanna Harasym, Remigiusz Olędzki
Minimally processed cereal breakfast products from whole grain entered the market due to consumer demand of more nutritional food with more controlled sugar release. However, the subsequent processing of such products with different cooking methods in the consumer's kitchen may lead to significant differentiation of their nutritional value. Therefore, the evaluation of the impact of frequently used cooking methods on a final quality of breakfast cereals meal is needed. The present study investigates how the two different methods of heating, conventional and microwave (MW) assisted, affect the carbohydrate content, profile and resulting glycemic index of so prepared food as well as the antioxidant activity of meals...
February 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29442404/cesarean-section-and-diabetes-during-pregnancy-an-nsw-population-study-using-the-robson-classification
#8
Reem Zeki, Jeremy J N Oats, Alex Y Wang, Zhuoyang Li, Caroline S E Homer, Elizabeth A Sullivan
AIM: The aim of this study was to identify the main contributors to cesarean section (CS) among women with and without diabetes during pregnancy using the Robson classification and to compare CS rates within Robson groups. METHODS: A population-based cohort study was conducted of all women who gave birth in New South Wales, Australia, between 2002 and 2012. Women with pregestational diabetes (types 1 and 2) and gestational diabetes mellitus (GDM) were grouped using the Robson classification...
February 14, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29440949/the-prevalence-of-long-term-oral-anticoagulation-therapy-in-a-cardiology-center-in-bucharest-romania
#9
Adelina-Mihaela Sorescu, Tudor Enache, Suzana Guberna
Background and aims: Few studies discuss the prevalence of oral anticoagulation therapy (OAT) in clinical practice, despite their increasing use worldwide. In America, studies established that 20% to 80% of the patients with indication benefit from OAT. In Romania, there is no data regarding the utilization of oral anticoagulants. Thus, this study aims to determine the trends of OAT. Methods: We designed a cross-sectional study of the patients admitted to the Cardiology Department of the "Bagdasar-Arseni" Clinical Emergency Hospital, Bucharest, from the 1st of November 2016 until the 31st of January 2017...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29437249/a-multifunctional-pincer-ligand-for-cobalt-promoted-oxidation-by-n2o
#10
Brian J Cook, Chun-Hsing G Chen, Kenneth G Caulton
The divalent cobalt complex of the diprotic pincer ligand bis-pyrazolylpyridine, (H2L)CoCl2, is dehydrohalogenated twice by LiN(SiMe3)2 in the presence of PEt3 to give monomeric S = 1/2 LCo(PEt3)2, fully characterized in solid and solution as a square pyramidal monomer with a long axial Co-P bond. This 17 electron species reacts in time of mixing with N2O to form L2Co2(OPEt3) + 3 OPEt3, the former the first example of phosphine oxide bridging two transition metals. The same products are formed from O2, and divalent cobalt persists even in the presence of excess oxidant...
February 13, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29433307/role-of-hepatic-organic-anion-transporter-2-in-the-pharmacokinetics-of-r-and-s-warfarin-in-vitro-studies-and-mechanistic-evaluation
#11
Yi-An Bi, Jian Lin, Sumathy Mathialagan, Laurie Tylaska, Ernesto Callegari, A David Rodrigues, Manthena V S Varma
Inter-individual variability in warfarin dose requirement demands personalized medicine approaches to balance its therapeutic benefits (anticoagulation) and bleeding risk. Cytochrome P450 2C9 (CYP2C9) genotype-guided warfarin dosing is recommended in the clinic, given the more potent S-warfarin is primarily metabolized by CYP2C9. However, only about 20-30% of inter-patient variability in S-warfarin clearance is associated with CYP2C9 genotype. We evaluated the role of hepatic uptake in the clearance of R- and S-warfarin...
February 12, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29431835/processing-of-oat-the-impact-on-oat-s-cholesterol-lowering-effect
#12
REVIEW
Myriam M-L Grundy, Anthony Fardet, Susan M Tosh, Gillian T Rich, Peter J Wilde
Epidemiological and interventional studies have clearly demonstrated the beneficial impact of consuming oat and oat-based products on serum cholesterol and other markers of cardiovascular disease. The cholesterol-lowering effect of oat is thought to be associated with the β-glucan it contains. However, not all food products containing β-glucan seem to lead to the same health outcome. Overall, highly processed β-glucan sources (where the oat tissue is highly disrupted) appear to be less effective at reducing serum cholesterol, but the reasons are not well understood...
February 12, 2018: Food & Function
https://www.readbyqxmd.com/read/29427574/new-product-identification-in-the-sterol-metabolism-by-an-industrial-strain-mycobacterium-neoaurum-nrrl-b-3805
#13
Xuemei Li, Xi Chen, Yu Wang, Peiyuan Yao, Rui Zhang, Jinhui Feng, Qiaqing Wu, Dunming Zhu, Yanhe Ma
Mycobacterium neoaurum NRRL B-3805 metabolizes sterols to produce androst-4-en-3,17-dione (AD) as the main product, and androsta-1,4-dien-3,17-dione, 9α-hydroxyandrost-4-en-3,17-dione and 22-hydroxy-23,24-bisnorchol-4-en-3-one have been identified as by-products. In this study, a new by-product was isolated from the metabolites of sterols and identified as methyl 3-oxo-23,24-bisnorchol-4-en-22-oate (BNC methyl ester), which was proposed to be produced via the esterification of BNC catalyzed by an O-methyltransferase using S-adenosyl-l-methionine as the methyl group donor...
February 7, 2018: Steroids
https://www.readbyqxmd.com/read/29427246/effect-of-feeding-oat-and-vetch-forages-on-milk-production-and-quality-in-smallholder-dairy-farms-in-central-kenya
#14
Solomon W Mwendia, Chris M Mwungu, Stanley Karanja Ng'ang'a, David Njenga, An Notenbaert
Despite the significant livestock contribution to households' nutrition and incomes in many African smallholder farms, milk productivity remains low. Inadequate feeding is the main reason for the underperformance. To contribute towards addressing this, an on-farm feeding trial was undertaken in Ol-joro-Orok Central Kenya. A feed basket using oat (Avena sativa) cv Conway and vetch (Vicia villosa) was compared to farmers practice. Milk production (kg) and quality parameters, including butterfat, protein, lactose, and density, were monitored, and cost-benefit analysis (CBA) undertaken...
February 9, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29426304/rationale-design-and-methodology-of-a-trial-evaluating-three-models-of-care-for-hcv-treatment-among-injection-drug-users-on-opioid-agonist-therapy
#15
Matthew J Akiyama, Linda Agyemang, Julia H Arnsten, Moonseong Heo, Brianna L Norton, Bruce R Schackman, Benjamin P Linas, Alain H Litwin
BACKGROUND: People who inject drugs (PWID) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). Treatment of PWID is complex due to addiction, mental illness, poverty, homelessness, lack of positive social support, poor adherence-related skills, low motivation and knowledge, and poor access to and trust in the health care system. New direct-acting antiviral medications are available for HCV with high cure rates and few side effects. The life expectancy and economic benefits of new HCV treatments will not be realized unless we determine optimal models of care for the majority of HCV-infected patients...
February 9, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29425234/targeted-liquid-chromatography-tandem-mass-spectrometry-to-quantitate-wheat-gluten-using-well-defined-reference-proteins
#16
Kathrin Schalk, Peter Koehler, Katharina Anne Scherf
Celiac disease (CD) is an inflammatory disorder of the upper small intestine caused by the ingestion of storage proteins (prolamins and glutelins) from wheat, barley, rye, and, in rare cases, oats. CD patients need to follow a gluten-free diet by consuming gluten-free products with gluten contents of less than 20 mg/kg. Currently, the recommended method for the quantitative determination of gluten is an enzyme-linked immunosorbent assay (ELISA) based on the R5 monoclonal antibody. Because the R5 ELISA mostly detects the prolamin fraction of gluten, a new independent method is required to detect prolamins as well as glutelins...
2018: PloS One
https://www.readbyqxmd.com/read/29421725/do-recommended-doses-of-glyphosate-based-herbicides-affect-soil-invertebrates-field-and-laboratory-screening-tests-to-risk-assessment
#17
Júlia Carina Niemeyer, Fernanda Benedet de Santo, Naiara Guerra, Altair Maçaneiro Ricardo Filho, Tatiani Maria Pech
Despite glyphosate-based herbicides are widely used in agriculture, forestry and gardens, little is known about its effects on non-target organisms. The present work evaluated the ecotoxicity of four formulated products (Roundup ® Original, Trop ® , Zapp ® Qi 620 and Crucial ® ) on soil invertebrates. Screening ecotoxicity tests were carried out with soil and oat straw collected in a field experiment, besides laboratory-spiked soils. Screening tests included avoidance behaviour of earthworms (Eisenia andrei), collembolans (Folsomia candida) and isopods (Porcellio dilatatus) in single and multispecies tests; reproduction of collembolans (F...
January 31, 2018: Chemosphere
https://www.readbyqxmd.com/read/29417475/enterocin-m-and-its-beneficial-effects-in-horses-a-pilot-experiment
#18
Andrea Lauková, Eva Styková, Ivana Kubašová, Soňa Gancarčíková, Iveta Plachá, Dagmar Mudroňová, Anna Kandričáková, Renata Miltko, Grzegorz Belzecki, Igor Valocký, Viola Strompfová
Probiotic bacteria or their antimicrobial proteinaceous substances called bacteriocins (enterocins) hold promising prophylactic potential for animal breeding. This study present the results achieved after application of Enterocin M in horses. Enterocin M has never been applied to horses before. Clinically healthy horses (10) were involved in this pilot experiment. They were placed in the stables of the University of Veterinary Medicine and Pharmacy, Košice, Slovakia, with the approval of the University Ethics Committee...
February 7, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29415856/a-qualitative-assessment-of-attitudes-about-and-preferences-for-extended-release-naltrexone-a-new-pharmacotherapy-to-treat-opioid-use-disorders-in-ukraine
#19
Ruthanne Marcus, Martha J Bojko, Alyona Mazhnaya, Iuliia Makarenko, Sergii Filippovych, Sergii Dvoriak, Frederick L Altice, Sandra A Springer
Numerous individual barriers, including negative attitudes toward opioid agonist therapies (OAT), have undermined HIV prevention efforts in Ukraine where the epidemic is concentrated in people who inject drugs (PWID). The recent availability of extended-release naltrexone (XR-NTX), an opioid antagonist, provides new opportunities for treatment and prevention, but little is known about patient preferences. We conducted qualitative analysis using focus groups (FG) of PWID recruited based on OAT experience: currently, previously, and never on OAT in five Ukrainian cities...
March 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29413907/ophthalmic-acid-is-a-marker-of-oxidative-stress-in-plants-as-in-animals
#20
Luigi Servillo, Domenico Castaldo, Alfonso Giovane, Rosario Casale, Nunzia D'Onofrio, Domenico Cautela, Maria Luisa Balestrieri
BACKGROUND: Ophthalmic acid (OPH), γ-glutamyl-L-2-aminobutyryl-glycine, a tripeptide analogue of glutathione (GSH), has recently captured considerable attention as a biomarker of oxidative stress in animals. The OPH and GSH biosynthesis, as well as some biochemical behaviors, are very similar. Here, we sought to investigate the presence of OPH in plants and its possible relationship with GSH, known to possess multiple functions in the plant development, growth and response to environmental changes...
January 31, 2018: Biochimica et Biophysica Acta
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