keyword
https://read.qxmd.com/read/38651797/knee-cartilage-injuries-in-football-players-clinical-outcomes-and-return-to-sport-after-surgical-treatment-a-systematic-review-of-the-literature
#1
JOURNAL ARTICLE
Luca Andriolo, Theodorakys Marín Fermín, Giulia Marcella Maryse Chiari Gaggia, Andreas Serner, Elizaveta Kon, Emmanuel Papakostas, Andrew Massey, Peter Verdonk, Giuseppe Filardo
OBJECTIVE: To systematically review the literature and analyze clinical outcomes and return-to-sport after surgical management of cartilage injuries in football players. DESIGN: A systematic literature review was performed in August 2023 on PubMed, WebOfScience, and Cochrane Library to collect studies on surgical strategies for cartilage lesions in football players. Methodological quality and risk of bias were assessed with the modified Coleman Methodology score and RoB2 and RoBANS2 tools...
April 23, 2024: Cartilage
https://read.qxmd.com/read/38649554/impact-of-the-covid-19-pandemic-on-hiv-test-uptake-among-people-who-inject-drugs-in-the-context-of-an-hiv-outbreak
#2
JOURNAL ARTICLE
Kirsten M A Trayner, Alan Yeung, Norah E Palmateer, Andrew McAuley, Max Wilkinson, Julie Craik, Rebecca Metcalfe, Erica Peters, Samantha J Shepherd, Rory N Gunson, Daniel Carter, Laura Sills, Sharon J Hutchinson
Glasgow, Scotland's largest city, has been experiencing an HIV outbreak among people who inject drugs (PWID) since 2015. A key focus of the public health response has been to increase HIV testing among those at risk of infection. Our aim was to assess the impact of COVID-19 on HIV testing among PWID in Glasgow. HIV test uptake in the last 12 months was quantified among: (1) PWID recruited in six Needle Exchange Surveillance Initiative (NESI) surveys (n = 6110); linked laboratory data for (2) people prescribed opioid agonist therapy (OAT) (n = 14,527) and (3) people hospitalised for an injecting-related hospital admission (IRHA) (n = 12,621) across four time periods: pre-outbreak (2010-2014); early-outbreak (2015-2016); ongoing-outbreak (2017-2019); and COVID-19 (2020-June 21)...
April 22, 2024: AIDS and Behavior
https://read.qxmd.com/read/38649380/chromosome-level-genome-assembly-of-the-diploid-oat-species-avena-longiglumis
#3
JOURNAL ARTICLE
Qing Liu, Gui Xiong, Ziwei Wang, Yongxing Wu, Tieyao Tu, Trude Schwarzacher, John Seymour Heslop-Harrison
Diploid wild oat Avena longiglumis has nutritional and adaptive traits which are valuable for common oat (A. sativa) breeding. The combination of Illumina, Nanopore and Hi-C data allowed us to assemble a high-quality chromosome-level genome of A. longiglumis (ALO), evidenced by contig N50 of 12.68 Mb with 99% BUSCO completeness for the assembly size of 3,960.97 Mb. A total of 40,845 protein-coding genes were annotated. The assembled genome was composed of 87.04% repetitive DNA sequences. Dotplots of the genome assembly (PI657387) with two published ALO genomes were compared to indicate the conservation of gene order and equal expansion of all syntenic blocks among three genome assemblies...
April 22, 2024: Scientific Data
https://read.qxmd.com/read/38646574/cow-milk-is-an-important-source-of-iodine-for-prenatal-health-and-switching-to-plant-based-milk-can-lead-to-iodine-insufficiencies
#4
REVIEW
Hallie Lundquist, Julie Hess, Madeline Comeau, Joanne Slavin
Iodine insufficiencies are common among many populations, particularly pregnant women. One of the main functions of iodine is making thyroid hormone. The 2 main hormones that iodine influences are triiodothyronine and thyroxine. Thyroid hormone affects metabolism of most tissues. For the average adult, the recommended dietary allowance (RDA) for iodine is 150 µg. During certain stages of life, such as pregnancy, lactation, and infancy, the importance of iodine is even greater as it supports brain, bone, and organ development...
May 2024: JDS Commun
https://read.qxmd.com/read/38645966/reasons-for-not-entering-opioid-agonist-treatment-a-survey-among-high-risk-opioid-users-in-finland
#5
JOURNAL ARTICLE
Tuire Prami, Mari Pölkki, Jarno Ruotsalainen, Elin Banke Nordbeck, Susanna Meyner, Ari Kaski
Aims: To characterise and understand the untreated high-risk opioid user population in Finland, and to determine the reasons why these people do not enter treatment. Methods: The study setting was a half-year cross-sectional survey in Finland during 2021-2022. An electronic questionnaire with 24 structured questions was concluded in 16 needle exchange units. Participants were opioid-dependent people without opioid agonist treatment (OAT), and they answered the survey voluntarily and anonymously. Results: Of the 167 respondents, 62% were men, 53% were aged ≤34 years, 66% had used opioids for >6 years, and 78% used drugs intravenously (IV) daily...
April 2024: Nordisk Alkohol- & Narkotikatidskrift: NAT
https://read.qxmd.com/read/38644677/prolonged-diacetylmorphine-take-home-during-the-covid-19-pandemic-results-of-a-retrospective-cohort-study
#6
JOURNAL ARTICLE
Franciska Brezan, Maximilian Meyer, Marc Vogel, Jakob Heimer, Luis Falcato, Jonas Montagna, Philip Bruggmann
BACKGROUND AND AIMS: Legal regulations for dispensing in Swiss heroin-assisted treatment were relaxed during the COVID-19 pandemic, allowing prolonged take-home of up to 7 days instead of two to reduce patient contact and the risk of infection. Our study aimed to measure the consequences of this new practice. DESIGN, SETTING AND PARTICIPANTS: This was a retrospective cohort study set in Switzerland's largest outpatient centre for opioid agonist therapy. One hundred and thirty-four (72...
April 21, 2024: Addiction
https://read.qxmd.com/read/38643409/troubleshooting-upper-airway-stimulation-therapy-using-drug-induced-sleep-endoscopy
#7
JOURNAL ARTICLE
Thomas M Kaffenberger, Andrea Plawecki, Praneet Kaki, Maurits Boon, Colin Huntley
OBJECTIVE: This study assesses the utility of drug-induced sleep endoscopy (DISE) in guiding further treatment for patients with obstructive sleep apnea (OSA) who have difficulty tolerating upper airway stimulation (UAS) or have inadequate response to therapy. STUDY DESIGN: We conducted a retrospective analysis of UAS patients at our institution who underwent DISE, post-UAS, and evaluated the efficacy of different electrode configurations and maneuvers. SETTING: A tertiary care hospital...
April 21, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38642648/ruminal-methane-emission-and-lactational-performance-of-cows-fed-rapeseed-cake-and-oats-on-a-grass-silage-based-diet
#8
JOURNAL ARTICLE
S E Räisänen, Þ H Sigurðardóttir, A Halmemies-Beauchet-Filleau, O Pitkänen, A Vanhatalo, A Sairanen, T Kokkonen
The objective of this experiment was to investigate the effect of lipid from rapeseed cake and oats on ruminal CH4 emission and lactational performance of dairy cows. Twelve lactating Nordic Red cows, of which 4 primiparous, and averaging (±SD) 48 ± 22.9 DIM, 37.8 ± 7.14 kg/d milk yield were enrolled in a switch-back design experiment with 3 periods of 4 wk each. The cows were assigned into 6 pairs based on parity and days-in-milk, milk yield, and body weight at the beginning of the experiment...
April 18, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38640512/reconstruction-of-remodeling-units-reveals-positive-effects-after-2-and-12%C3%A2-months-of-romosozumab-treatment
#9
JOURNAL ARTICLE
Erik F Eriksen, Rogely W Boyce, Yifei Shi, Jacques P Brown, Donald Betah, Cesar Libanati, Mary Oates, Roland Chapurlat, Pascale Chavassieux
Romosozumab treatment results in a transient early increase in bone formation and sustained decrease in bone resorption. Histomorphometric analyses revealed that the primary bone-forming effect of romosozumab is transient early stimulation of modeling-based bone formation on cancellous and endocortical surfaces; preclinical studies have demonstrated that romosozumab may affect changes in the remodeling unit resulting in positive bone balance. To further investigate the effects of romosozumab on bone balance, month 12 (M12) and M2 (to analyze early effects) unpaired bone biopsies from the FRAME clinical trial were analyzed using remodeling site reconstruction to assess whether positive changes in bone balance on cancellous/endocortical surfaces may contribute to the progressive improvement in bone mass/structure and reduced fracture risk in osteoporotic women at high fracture risk...
April 19, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38638626/a-novel-ornithine-aminotransferase-splice-site-mutation-causes-vitamin-b6-responsive-gyrate-atrophy
#10
Samira Molaei Ramshe, Safoura Zardadi, Elham Alehabib, Ramin Nourinia, Javad Jamshidi, Mohsen Soosanabadi, Hossein Darvish
PURPOSE: Gyrate atrophy of the choroid and retina (GACR) is a rare congenital disorder and mutations in the ornithine aminotransferase (OAT) gene has been specified as the underlying cause. Patients show a high level of ornithine in body fluids which may be controlled by low protein diets. Pyridoxine (vitamin B6) supplementation may also be effective, however, most patients appear to be nonresponsive to this modality of treatment. CASE REPORT: Here, we report a characterized case of a vitamin B6-responsive GACR who had a splicing mutation in the OAT gene...
2024: Journal of Ophthalmic & Vision Research
https://read.qxmd.com/read/38637090/investigation-of-the-growth-of-listeria-in-plant-based-beverages
#11
JOURNAL ARTICLE
Klaudia Bartula, Sambou Biagui, Máire Begley, Michael Callanan
The objective of the present study was to evaluate whether the content of sugar, protein, fat, or fibre in commercially available and specially formulated plant-based beverages (oat, soya and pea) influences the growth rates of Listeria. Beverages were inoculated with a strain cocktail of Listeria (approximately 1 × 103  CFU/mL), and the data demonstrated that Listeria could proliferate in all tested beverages. Moreover, varying concentrations of naturally occurring or added sugar (0-3.3%), protein (3...
August 2024: Food Microbiology
https://read.qxmd.com/read/38635035/kar-1-induced-dormancy-release-in-avena-fatua-caryopses-involves-reduction-of-caryopsis-sensitivity-to-aba-and-aba-ga-s-ratio-in-coleorhiza-and-radicle
#12
JOURNAL ARTICLE
Jan Kępczyński, Michal Dziurka, Agata Wójcik
The dormancy release by KAR1 is associated with a reduction of coleorhiza and radicle sensitivity to ABA as well as with reduction the ABA/GAs ratio in the coleorhiza, by a decrease content of ABA, and in the radicle, by a decrease the ABA and an increase of the GAs contents. Both, karrikin 1 (KAR1 ) and gibberellin A3 (GA3 ), release dormancy in Avena fatua caryopses, resulting in the emergence of coleorhiza (CE) and radicle (RE). Moreover, KAR1 and GA3 stimulate CE and RE in the presence of abscisic acid (ABA), the stimulation being more effective in CE...
April 18, 2024: Planta
https://read.qxmd.com/read/38634599/aphid-parasitism-in-winter-wheat-fields-in-a-heterogeneous-agricultural-landscape
#13
JOURNAL ARTICLE
Norman C Elliott, Kristopher L Giles, Kristen A Baum, Sarah D Elzay, Georges F Backoulou
The number, timing, and fitness of colonizing parasitoids in fields of ephemeral crops often depend on factors external to the fields. We investigated cereal aphid parasitism in 23 winter wheat fields using sentinel plants infested with bird cherry-oat aphids, Rhopalosiphum padi (L.) (Hemiptera: Aphididae), and we investigated the effect of parasitoids on cereal aphid population growth using exclusion and parasitoid-accessible cages infested with bird cherry-oat aphids. Lysiphlebus testaceipes (Cresson) (Hymenoptera: Braconidae), Aphelinus nigritus (Howard) (Hymenoptera: Aphelinidae), and Diaeretiella rapae (McIntosh) (Hymenoptera: Braconidae), in decreasing order of abundance, parasitized R...
April 18, 2024: Journal of Economic Entomology
https://read.qxmd.com/read/38633698/transcriptomic-analysis-of-the-response-of-avena-sativa-to-bacillus-amyloliquefaciens-dgl1
#14
JOURNAL ARTICLE
Xue Yang, Yongli Xie, Tian Wang, Youming Qiao, Junxi Li, Lingling Wu, Ying Gao
INTRODUCTION: Bacillus amyloliquefaciens DGL1, isolated from the arid sandy areas in Dagler, Qinghai Province, China, promotes the growth of Avena sativa variety "Qing Yan 1". METHODS: To elucidate the transcriptomic changes in the oat root system following interaction with DGL1 and to reveal the molecular mechanism by which DGL1 promotes oat growth, treatment and control groups of oat roots at 2, 4, 8, and 12 h after inoculation with a suspension of strain DGL1 were analyzed using Illumina high-throughput transcriptome sequencing technology...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38631671/prevalence-of-opioid-dependence-in-scotland-2015-2020-a-multi-parameter-estimation-of-prevalence-mpep-study
#15
JOURNAL ARTICLE
Andreas Markoulidakis, Matthew Hickman, Andrew McAuley, Lee R Barnsdale, Nicky J Welton, Megan Glancy, Tara Shivaji, Craig Collins, Jaroslaw Lang, Femke de Wit, Gordon Hunt, Levin Wilkinson, Rosalyn Fraser, Alan Yeung, Kirsten Horsburgh, Saket Priyadarshi, Sharon J Hutchinson, Hayley E Jones
BACKGROUND AND AIMS: Drug-related deaths in Scotland more than doubled between 2011 and 2020. To inform policymakers and understand drivers of this increase, we estimated the number of people with opioid dependence aged 15-64 from 2014/15 to 2019/20. DESIGN: We fitted a Bayesian multi-parameter estimation of prevalence (MPEP) model, using adverse event rates to estimate prevalence of opioid dependence jointly from Opioid Agonist Therapy (OAT), opioid-related mortality and hospital admissions data...
April 17, 2024: Addiction
https://read.qxmd.com/read/38631591/rheological-thermal-and-in-vitro-starch-digestibility-properties-of-oat-starch-lipid-complexes
#16
JOURNAL ARTICLE
Meng Shen, Kai Huang, Hongwei Cao, Yu Zhang, Zhu Sun, Zhiquan Yu, Xiao Guan
The influence of oat lipids on the structural, thermal, rheological, and in vitro digestibility properties of oat starch under heat processing conditions was investigated. X-ray diffraction, fourier infrared spectroscopy, and differential scanning calorimetry revealed the formation of a V-shaped crystal structure between starch and lipid, resulting in enhanced orderliness and enthalpy. Oat lipids decreased the final viscosity and gel strength of oat starch while weakening the trend towards gel network formation...
April 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38630468/design-synthesis-and-mechanistic-studies-of-r-3-amino-5-5-difluorocyclohex-1-ene-1-carboxylic-acid-as-an-inactivator-of-human-ornithine-aminotransferase
#17
JOURNAL ARTICLE
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio M Ferreira, Graham Moran, Neil L Kelleher, Dali Liu, Richard B Silverman
Human ornithine aminotransferase ( h OAT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, has been shown to play an essential role in the metabolic reprogramming and progression of hepatocellular carcinoma (HCC). HCC accounts for approximately 75% of primary liver cancers and is within the top three causes of cancer death worldwide. As a result of treatment limitations, the overall 5-year survival rate for all patients with HCC is under 20%. The prevalence of HCC necessitates continued development of novel and effective treatment methods...
April 17, 2024: ACS Chemical Biology
https://read.qxmd.com/read/38628205/effects-of-blending-ratio-variation-on-macronutrient-compositions-and-sensory-acceptability-of-dabi-teff-field-pea-based-novel-composite-complementary-flours
#18
JOURNAL ARTICLE
Diriba Chewaka Tura, Tefera Belachew, Dessalegn Tamiru, Kalkidan Hassen Abate
The response of a mixed system is determined by the proportions of the various ingredients that add up to one, not by the combination's total amount. This research aimed at examining the effects of blending ratio variation on the macro-composition and sensory acceptability of dabi teff-field pea-based novel composite complementary flours. Standard methods (AOAC, 2016, Official Methods of Analysis of the Association of Official Analytical Chemists ) were used to determine macronutrients. The sensory attributes were evaluated using a 5-point hedonic scale...
April 2024: Food Science & Nutrition
https://read.qxmd.com/read/38627096/-characterization-of-hoat4-and-moat5-as-functional-orthologs-for-renal-anion-uptake-and-efflux-transport
#19
JOURNAL ARTICLE
Lucy J Martinez-Guerrero, Xiaohong Zhang, Stephen H Wright, Nathan J Cherrington
Organic anions (OA) are compounds including drugs or toxicants that are negatively charged at physiological pH and are typically transported by Organic Anion Transporters (OATs). Human OAT4 (SLC22A11) is expressed in the apical membrane of renal proximal tubules. Although there is no rodent ortholog of hOAT4, rodents express Oat5 (Slc22a19), an anion exchanger that is also localized to the apical membrane of renal proximal tubule cells. The purpose of this study was to determine the functional similarity between mouse Oat5 and human OAT4...
April 16, 2024: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/38626996/barriers-and-facilitators-for-family-physicians-prescribing-opioid-agonist-therapy-in-saskatchewan
#20
JOURNAL ARTICLE
Teresa Nguyen, Julia Bareham, Katelyn Halpape
OBJECTIVE: To explore barriers and facilitators for family physicians in Saskatchewan prescribing opioid agonist therapy (OAT). DESIGN: Self-administered postal survey. SETTING: Family medicine practices in Saskatchewan. PARTICIPANTS: A total of 218 Saskatchewan family physicians who were not authorized to prescribe OAT as of June 2022. MAIN OUTCOME MEASURES: Descriptive and inferential statistics of physicians' self-reported barriers to and facilitators of prescribing OAT for opioid use disorder (OUD)...
April 2024: Canadian Family Physician Médecin de Famille Canadien
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