keyword
https://read.qxmd.com/read/38450431/drug-interactions-of-carbonic-anhydrase-inhibitors-and-activators
#1
REVIEW
Claudiu T Supuran
INTRODUCTION: . Carbonic anhydrases (CAs, EC 4.2.1.1) have been established drug targets for decades, with their inhibitors and activators possessing relevant pharmacological activity and applications in various fields. At least 11 sulfonamides/sulfamates are clinically used as diuretics, antiglaucoma, antiepileptic, or antiobesity agents and one derivative, SLC-0111, is in clinical trials as antitumor/antimetastatic agent. The activators were less investigated with no clinically used agent...
March 7, 2024: Expert Opinion on Drug Metabolism & Toxicology
https://read.qxmd.com/read/38344484/clinical-disease-and-outcomes-of-invasive-staphylococcus-lugdunensis-infection-in-a-university-hospital-in-saudi-arabia
#2
JOURNAL ARTICLE
Reham Kaki
Background Staphylococcus lugdunensis is a pathogen that can cause various diseases in humans, of which bacteremia and infective endocarditis have been described most extensively. In Saudi Arabia, reports of  S. lugdunensis infection are extremely rare, and no studies have reported S. lugdunensis antibiotic susceptibility. The objective of this study was to determine S. lugdunensis clinical disease, potential risk factors, susceptibility pattern, and 30-day mortality. Methods A retrospective study was performed at King Abdulaziz University Hospital in Jeddah, Saudi Arabia, from January 1, 2015, to December 31, 2022...
January 2024: Curēus
https://read.qxmd.com/read/38332425/optimizing-antibiotic-therapy-for-intravenous-drug-users-a-narrative-review-unraveling-pharmacokinetics-pharmacodynamics-challenges
#3
JOURNAL ARTICLE
Marta Colaneri, Camilla Genovese, Pietro Valsecchi, Matteo Calia, Dario Cattaneo, Andrea Gori, Raffaele Bruno, Elena Seminari
Intravenous drug users (IVDUs) face heightened susceptibility to life-threatening gram-positive bacterial infections, particularly methicillin-resistant Staphylococcus aureus (MRSA). While the standard antibiotic dosing strategies for special patients, such as obese or critically ill individuals, are known to be inadequate, raising concerns about treatment efficacy, a similar sort of understanding has not been assessed for IVDUs yet. With this in mind, this review examines the pharmacokinetic/pharmacodynamic characteristics of antibiotics commonly used against gram-positive bacteria in IVDUs...
February 8, 2024: European Journal of Drug Metabolism and Pharmacokinetics
https://read.qxmd.com/read/37971650/how-to-dose-vancomycin-in-overweight-and-obese-patients-with-varying-renal-dys-function-in-the-novel-era-of-auc-400-600-mg%C3%A2-h-l-targeted-dosing
#4
JOURNAL ARTICLE
Tan Zhang, Elke H J Krekels, Cornelis Smit, Eric P A van Dongen, Roger J M Brüggemann, Catherijne A J Knibbe
BACKGROUND AND OBJECTIVE: The latest vancomycin guideline recommends area under the curve (AUC)-targeted dosing and monitoring for efficacy and safety. However, guidelines for AUC-targeted starting dosing in patients with obesity and/or renal insufficiency are currently lacking. This study quantifies the pharmacokinetics (PK) of vancomycin in this population and provides AUC-targeted dosing recommendations. METHODS: Vancomycin concentrations (n = 1188) from therapeutic drug monitoring of 210 overweight and obese patients with varying degrees of renal (dys)function from the ward (74...
November 16, 2023: Clinical Pharmacokinetics
https://read.qxmd.com/read/37862131/external-validation-of-obese-and-critically-ill-vancomycin-population-pharmacokinetic-models-in-critically-ill-obese-patients
#5
JOURNAL ARTICLE
Abdullah Alsultan, Shereen A Dasuqi, Abdullah Almohaizeie, Abdullah Aljutayli, Fadi Aljamaan, Rasha A Omran, Abdulaziz Alolayan, Mohammed A Hamad, Haifa Alotaibi, Sarah Altamimi, Sarah S Alghanem
Obesity combined with critical illness might increase the risk of acquiring infections and hence mortality. In this patient population antimicrobials pharmacokinetics vary significantly making antimicrobial dosing challenging. The objective of this study was to assess the predictive performance of published population pharmacokinetic models of vancomycin in critically ill or obese patients on a cohort of critically ill obese patients. This was a multi-center retrospective study conducted at two hospitals. Adult patients with a BMI ≥ 30 were included...
October 20, 2023: Journal of Clinical Pharmacology
https://read.qxmd.com/read/37542419/agreement-between-two-concentration-and-one-concentration-area-under-the-curve-auc-estimates-when-using-bayesian-modeling-to-dose-vancomycin-in-patients-with-obesity
#6
JOURNAL ARTICLE
Elizabeth W Covington, Addison M Watkins
BACKGROUND: Vancomycin Bayesian modeling provides 24-hour area under the curve (AUC24) estimations. However, the agreement between two-concentration and one-concentration Bayesian estimates in patients with obesity is unknown. OBJECTIVE: The purpose of this study was to determine the agreement between two-concentration and one-concentration Bayesian AUC24 estimates in patients with obesity receiving vancomycin. METHODS: This retrospective within-subjects cohort study included patients with obesity and two vancomycin concentrations...
August 5, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37421628/high-fat-diet-associated-intestinal-microbiota-exacerbates-psoriasis-like-inflammation-by-enhancing-systemic-%C3%AE-%C3%AE-t%C3%A2-cell-il-17-production
#7
JOURNAL ARTICLE
Koshiro Sonomoto, Rui Song, Daniel Eriksson, Anne M Hahn, Xianyi Meng, Pang Lyu, Shan Cao, Ning Liu, R Verena Taudte, Stefan Wirtz, Yoshiya Tanaka, Thomas H Winkler, Georg Schett, Didier Soulat, Aline Bozec
Although it is known that psoriasis is strongly associated with obesity, the mechanistic connection between diet and skin lesions is not well established. Herein, we showed that only dietary fat, not carbohydrates or proteins, exacerbates psoriatic disease. Enhanced psoriatic skin inflammation was associated with changes in the intestinal mucus layer and microbiota composition by high-fat diet (HFD). Change of intestinal microbiota by vancomycin treatment effectively blocked activation of psoriatic skin inflammation by HFD, inhibited the systemic interleukin-17 (IL-17) response, and led to increased mucophilic bacterial species such as Akkermansia muciniphila...
July 6, 2023: Cell Reports
https://read.qxmd.com/read/37368421/evaluation-of-real-world-vancomycin-dosing-and-attainment-of-therapeutic-drug-monitoring-targets
#8
JOURNAL ARTICLE
Nicole Bradley, Kimberly Ng
In 2020, the Infectious Diseases Society of America (IDSA) recommended a change in vancomycin therapeutic drug monitoring from trough-based to AUC/MIC-based to optimize vancomycin's efficacy and reduce nephrotoxicity. Many hospitals have not implemented this change due to barriers such as the cost of AUC/MIC software and lack of provider familiarity. The purpose of this study was to determine the rate of AUC/MIC ratio target attainment using current trough-based vancomycin dosing practices at a city hospital...
June 6, 2023: Pharmacy (Basel, Switzerland)
https://read.qxmd.com/read/37033643/dose-optimization-of-vancomycin-in-obese-patients-a-systematic-review
#9
Mahmoud E Elrggal, Abdul Haseeb, Manal AlGethamy, Umar Ahsan, Zikria Saleem, Areej Sultan Althaqafi, Sattam Saad Alshuail, Zohair Ahmad Alsiddiqi, Muhammad Shahid Iqbal, Albaraa Faraj Alzahrani, Abdullmoin AlQarni, Rozan Mohammad Radwan, Ameer Khalid Saab Qul, Ahmad Jamal Mahrous, Jumana Majdi Alsharif, Mayyasah Khalid Alqurashi, Hani Saleh Faidah, Mohammed Aldurdunji
Background: Dose optimization of vancomycin plays a substantial role in drug pharmacokinetics because of the increased incidence of obesity worldwide. This systematic review was aimed to highlight the current dosing strategy of vancomycin among obese patients. Methods: This systematic review was in concordance with Preferred Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The literature search was carried out on various databases such as Scopus, PubMed/MEDLINE, ScienceDirect and EMBASE using Keywords and MeSH terms related to vancomycin dosing among obese patients...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37017883/vancomycin-clearance-in-obese-adults-is-not-predictive-of-clearance-in-obese-adolescents
#10
JOURNAL ARTICLE
Tan Zhang, Cornelis Smit, Catherine M T Sherwin, Catherijne A J Knibbe, Elke H J Krekels
BACKGROUND AND OBJECTIVE: Contradictory pharmacokinetic (PK) results have been observed between obese adults and obese adolescents, with absolute clearance (CL) reported to be either unaltered, lower, or higher in obese adolescents compared to obese adults. This study investigates the PK of vancomycin in adolescents and adults who are overweight or obese. METHODS: Data from 125 overweight and obese adolescents (aged 10-18 years, weight 28.3-188 kg) and 81 overweight and obese adults (aged 29-88 years, weight 66...
April 5, 2023: Clinical Pharmacokinetics
https://read.qxmd.com/read/37009360/daptomycin-rifampin-induced-rhabdomyolysis-acute-renal-failure-and-hepatic-injury-a-case-report-and-literature-review
#11
Venu M Ganipisetti, Natasha Dudiki, Anand Athavale, Pratyusha Bollimunta, Babu Sriram Maringanti
Daptomycin is a canonical antibiotic used very commonly in practice for its bactericidal activity against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, bone infections, skin and soft tissue infections, meningitis, urinary tract infections, and endocarditis. Although daptomycin in conventional doses is usually well tolerated, it is paramount to be aware of the possible adverse effects. Daptomycin is reported to cause an elevation in creatine kinase levels, although frank rhabdomyolysis is rare...
March 2023: Curēus
https://read.qxmd.com/read/36835461/impact-of-vancomycin-treatment-and-gut-microbiota-on-bile-acid-metabolism-and-the-development-of-non-alcoholic-steatohepatitis-in-mice
#12
JOURNAL ARTICLE
Kaichi Kasai, Naoya Igarashi, Yuki Tada, Koudai Kani, Shun Takano, Tsutomu Yanagibashi, Fumitake Usui-Kawanishi, Shiho Fujisaka, Shiro Watanabe, Mayuko Ichimura-Shimizu, Kiyoshi Takatsu, Kazuyuki Tobe, Koichi Tsuneyama, Yukihiro Furusawa, Yoshinori Nagai
The potential roles of the gut microbiota in the pathogenesis of non-alcoholic fatty liver disease, including non-alcoholic steatohepatitis (NASH), have attracted increased interest. We have investigated the links between gut microbiota and NASH development in Tsumura-Suzuki non-obese mice fed a high-fat/cholesterol/cholate-based (iHFC) diet that exhibit advanced liver fibrosis using antibiotic treatments. The administration of vancomycin, which targets Gram-positive organisms, exacerbated the progression of liver damage, steatohepatitis, and fibrosis in iHFC-fed mice, but not in mice fed a normal diet...
February 17, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36557680/the-weissella-genus-clinically-treatable-bacteria-with-antimicrobial-probiotic-effects-on-inflammation-and-cancer
#13
REVIEW
Sadia Ahmed, Sargun Singh, Vaidhvi Singh, Kyle D Roberts, Arsalan Zaidi, Alexander Rodriguez-Palacios
Weissella is a genus earlier considered a member of the family Leuconostocaceae, which was reclassified into the family Lactobacillaceae in 1993. Recently, there have been studies emphasizing the probiotic and anti-inflammatory potential of various species of Weissella , of which W. confusa and W. cibaria are the most representative. Other species within this genus include: W. paramesenteroides, W. viridescens, W. halotolerans, W. minor, W. kandleri, W. soli, W...
December 7, 2022: Microorganisms
https://read.qxmd.com/read/36267260/evaluation-of-vancomycin-accumulation-in-patients-with-obesity
#14
JOURNAL ARTICLE
Maha S Assadoon, Jeffrey C Pearson, David W Kubiak, Mary P Kovacevic, Brandon W Dionne
BACKGROUND: Current vancomycin guidelines recommend early and frequent area-under-the-curve monitoring in patients with obesity. Vancomycin's volume of distribution is likely altered in patients with obesity, which may result in lower serum concentrations initially but lead to accumulation with continued use. The objective of this study was to evaluate the incidence of vancomycin accumulation in patients with obesity and identify potential factors associated with accumulation. METHODS: This was a single-center, retrospective, observational study at a tertiary academic medical center...
October 2022: Open Forum Infectious Diseases
https://read.qxmd.com/read/36253942/antibiotics-administration-alleviates-the-high-fat-diet-induced-obesity-through-altering-the-lipid-metabolism-in-young-mice
#15
JOURNAL ARTICLE
Shiyue Luo, Hongyang Zhang, Xuejun Jiang, Yinyin Xia, Shixin Tang, Xinhao Duan, Wei Sun, Min Gao, Chengzhi Chen, Zhen Zou, Lixiao Zhou, Jingfu Qiu
Currently, there is a global trend of rapid increase in obesity, especially among adolescents. The antibiotics cocktails (ABX) therapy is commonly used as an adjunctive treatment for gut microbiota related diseases, including obesity. However, the effects of broad-spectrum antibiotics alone on young obese hosts have rarely been reported. In the present study, the 3-week-old C57BL/6J male mice fed a high-fat diet (HFD) were intragastric administration with ampicillin, vancomycin, metronidazole or neomycin for 30 days...
October 17, 2022: Lipids
https://read.qxmd.com/read/36060337/measuring-epidemiologic-effects-of-enterococcal-bacteremia-and-outcomes-from-a-nationwide-inpatient-sample-database
#16
JOURNAL ARTICLE
Pramil Cheriyath, Ankita Prasad, Premalkumar Patel, Varun Vankeshwaram, Sheilabi Seeburun, Kajal Ghodasara, Sandeep Pavuluri
Introduction Enterococcus is a gram-positive, non-sporing, facultative anaerobe. It is a common cause of nosocomial infections in the United States. Enterococcal bacteremia is primarily a nosocomial infection in the medical intensive care unit (ICU), with a preference for elderly patients with multiple comorbidities.  Material and methods This is a retrospective cohort study using the publicly accessible National (Nationwide) Inpatient Sample (NIS) database from October 2015 to December 2017. We examined data from 75,430 patients aged 18 years and older in the NIS who developed enterococcal bacteremia, as identified from the ICD-10 CM codes (B95), to discuss the epidemiologic effects and outcomes of enterococcal bacteremia...
July 2022: Curēus
https://read.qxmd.com/read/35981345/vancomycin-dosing-in-patients-with-obesity
#17
JOURNAL ARTICLE
Brian L Erstad, Kathryn R Matthias, David E Nix
In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
August 18, 2022: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/35949852/vancomycin-dosing-in-an-obese-patient-with-acute-renal-failure-a-case-report-and-review-of-literature
#18
Kun-Yan Xu, Dan Li, Zhen-Jie Hu, Cong-Cong Zhao, Jing Bai, Wen-Li Du
BACKGROUND: Vancomycin is the most commonly used drug for methicillin-resistant Staphylococcus aureus . The empirical clinical doses of vancomycin based on non-obese patients may not be optimal for obese ones. CASE SUMMARY: This study reports a case of vancomycin dosing adjustment in an obese patient (body mass index 78.4 kg/m2 ) with necrotizing fasciitis of the scrotum and left lower extremity accompanied with acute renal failure. Dosing adjustment was performed based on literature review and factors that influence pharmacokinetic parameters are analyzed...
June 26, 2022: World Journal of Clinical Cases
https://read.qxmd.com/read/35927907/a-brief-review-of-pharmacokinetic-assessments-of-vancomycin-in-special-groups-of-patients-with-altered-pharmacokinetic-parameters
#19
JOURNAL ARTICLE
Parisa Ghasemiyeh, Afsaneh Vazin, Soliman Mohammadi-Samani
Vancomycin is considered the drug of choice against many Gram-positive bacterial infections. Therapeutic drug monitoring (TDM) is essential to achieve an optimum clinical response and avoid vancomycin-induced adverse reactions including nephrotoxicity. Although different studies are available on vancomycin TDM, still there are controversies regarding the selection among different pharmacokinetic parameters including trough concentration, the area under the curve to minimum inhibitory concentration ratio (AUC24h/MIC), AUC of intervals, elimination constant, and vancomycin clearance...
August 1, 2022: Current Drug Safety
https://read.qxmd.com/read/35898248/assessing-nephrotoxicity-associated-with-different-vancomycin-dosing-modalities-in-obese-patients-at-a-community-hospital
#20
JOURNAL ARTICLE
Amanda Wolfe, Jonathan Bowling, Marintha R Short, Greg Mateyoke, Steven C Berger
Background: Vancomycin requires therapeutic drug monitoring (TDM) based on its pharmacokinetic properties, and guidelines have shifted to analyzing area under the curve over 24 hours (AUC24) rather than trough concentrations due to nephrotoxicity concerns and correlation to efficacy. Obesity is an established risk factor for vancomycin-induced nephrotoxicity due to increased drug exposure based on dosing calculations and volume of distribution estimation. The aim of this study is to assess the relationship between AUC-based versus trough-based dosing and nephrotoxicity among obese patients receiving vancomycin...
August 2022: Hospital Pharmacy
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