Chongling Zhang, Wenyuan Zhang, Shuyue Zhu, Chunjie Hu, Sihua Che, Meiling Wang, Mengli Jin, Nan Bian, Wu Song, Shuang Jiang, Yijing Jiang, Juan Hou, Chang Liu, Haofang Zhou, Lin Wei, Guijun Shi, Yong Tang
Staphylococcus aureus (S. aureus) induces a variety of infectious diseases in humans and animals and is responsible for hospital- and community-acquired infections. The aim of this study was to investigate how bilobetin, a natural compound, attenuates S. aureus virulence by inhibiting two key virulence factors, von Willebrand factor-binding protein (vWbp) and staphylocoagulase (Coa). The results showed that bilobetin inhibited Coa- or vWbp-induced coagulation without affecting S. aureus proliferation. The Western blotting and fluorescence quenching assays indicated that bilobetin did not affect the expression of vWbp and Coa but directly bound to the proteins with KA values of 1...
October 27, 2023: World Journal of Microbiology & Biotechnology