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Obstructive Sleep Apnoea

Richard W W Lee
No abstract text is available yet for this article.
March 6, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Lily Chen, Julia L Chapman, Brendon J Yee, Keith K H Wong, Ronald R Grunstein, Nathaniel S Marshall, Christopher B Miller
OBJECTIVES: Originally developed as a paper questionnaire, the electronic Epworth Sleepiness Scale (ESS) is widely used in sleep clinics and sleep population research. Despite potential differences between computer-based and conventional questionnaire delivery, studies have not evaluated the agreement between electronic and paper versions of the ESS. Given the widespread use of the ESS, a bias between results would present considerable data concerns. Thus, the aim of this study was to examine agreement between electronic and paper ESS responses in obstructive sleep apnoea (OSA)...
March 8, 2018: BMJ Open
Stéphanie Conotte, Alexandra Tassin, Raphaël Conotte, Jean-Marie Colet, Karim Zouaoui Boudjeltia, Alexandre Legrand
Chronic intermittent hypoxia (ChIH) is a dominant feature of obstructive sleep apnoea (OSA) and is associated to metabolic alterations and oxidative stress (OS). Although management of OSA is well established, the research of new biomarkers that are independent of confounding factors remains necessary to improve the early detection of comorbidity and therapeutic follow-up. In this study, the urinary metabonomic profile associated to intermittent hypoxia was evaluated in a mouse model. When exposed to intermittent hypoxia, animals showed a significant alteration in energy metabolism towards anaerobic pathways and signs of OS imbalance...
March 6, 2018: Respiratory Physiology & Neurobiology
F Santamaria-Martos, I Benítez, C Girón, F Barbé, M A Martínez-García, L Hernández, J M Montserrat, E Nagore, A Martorell-Calatayud, F Campos-Rodriguez, J Corral, V Cabriada, J Abad, O Mediano, M F Troncoso, I Cano-Pumarega, A M Fortuna Gutierrez, T Diaz-Cambriles, M Somoza-Gonzalez, I Almendros, R Farre, D Gozal, M Sánchez-de-la-Torre
The goal of this study was to assess the relationship between the severity of OSA and the levels of carcinogenesis- and tumour growth-related biomarkers, in patients with cutaneous melanoma (CM).This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea-hypopnoea index (AHI); 0-5 events/h), mild-OSA (AHI; 5-15 events/h), and moderate to severe OSA (AHI>15 events/h). Enzyme-linked immunosorbent assays (ELISAs) were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (VEGF, IL8, ICAM-1, VCAM-1), and markers of tumour aggressiveness (S100B, MIA)...
March 9, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Qian Han, Guihua Li, Mary SiuMan Ip, Yuelin Zhang, Zhe Zhen, Judith ChoiWo Mak, Nuofu Zhang
Obstructive sleep apnoea (OSA) characterized by intermittent hypoxia (IH) is closely associated with cardiovascular diseases. IH confers cardiac injury via accelerating cardiomyocyte apoptosis, whereas the underlying mechanism has remained largely enigmatic. This study aimed to explore the potential mechanisms involved in the IH-induced cardiac damage performed with the IH-exposed cell and animal models and to investigate the protective effects of haemin, a potent haeme oxygenase-1 (HO-1) activator, on the cardiac injury induced by IH...
March 7, 2018: Journal of Cellular and Molecular Medicine
Vladimira Timkova, Iveta Nagyova, Sijmen A Reijneveld, Ruzena Tkacova, Roy E Stewart, Jitse P van Dijk, Ute Bültmann
We aimed to assess the prevalence of suicidal ideation and to examine the relationships between obstructive sleep apnoea severity, sleep-related problems, social support and suicidal ideation in obstructive sleep apnoea patients. We included 149 patients (68% male; mean age, 48.99 ± 9.57 years) with diagnosed obstructive sleep apnoea (Apnoea-Hypopnoea Index ⩾5) based on full-night polysomnography. The prevalence of suicidal ideation among obstructive sleep apnoea patients was 20.1 per cent. Structural equation modelling showed that suicidal ideation in obstructive sleep apnoea was strongly related to poor sleep quality and high fatigue levels...
February 1, 2018: Journal of Health Psychology
Kirit Arumalla, Vitish Singla, Sandeep Aggarwal, Harshit Garg, Ritesh Goel, Varidh Katiyar
Introduction: There is a worldwide increase in the prevalence of obesity among the adolescent population in India from 16.3% in 2001 to 19.3% in 2010. Recent evidence suggests that bariatric surgery leads to resolution of comorbidities and associated long-term complications in adolescent patients with morbid obesity. Aim: The aim of this study is to determine the impact of bariatric surgery on the weight loss and comorbidities of morbidly obese adolescents. Materials and Methods: A retrospective review of the data of 10 adolescent patients, who underwent Laparoscopic Sleeve Gastrectomy at our institute (tertiary care hospital), from July 2009 to July 2016 was carried out...
February 27, 2018: Journal of Minimal Access Surgery
Poul Jennum, Lone Baandrup, Philip Tønnesen, Rikke Ibsen, Jakob Kjellberg
BACKGROUND: This study aimed to evaluate all-cause mortality in relation to the use of benzodiazepines, antidepressants and antipsychotics in obstructive sleep apnoea (OSA) patients and matched controls. METHODS: Patients with a diagnosis of OSA and no pre-index use of psychotropic medication (n = 38,735) were compared with control subjects (n = 75,941) matched by age, gender, marital status and community location. National register data were used to obtain information on diagnoses (the Danish National Patient Registry), mortality (the Central Person Register) and psychotropic medication use (the Danish Register on Medicinal Product Statistics)...
March 2018: Sleep Medicine
Jean Louis Pépin, Sebastien Bailly, Renaud Tamisier
No abstract text is available yet for this article.
February 24, 2018: Thorax
Sébastien Baillieul, Bernard Wuyam, Jean-Louis Pépin, Mathieu Marillier, Renaud Tamisier, Dominic Pérennou, Samuel Verges
STUDY AIM: Severe obstructive sleep apnoea (OSA) can lead to neurocognitive alterations, including gait impairments. The beneficial effects of continuous positive airway pressure (CPAP) on improving excessive daytime sleepiness and daily functioning have been documented. However, a demonstration of CPAP treatment efficacy on gait control is still lacking. This study aims to test the hypothesis that CPAP improves gait control in severe OSA patients. MATERIAL AND METHODS: In this prospective controlled study, twelve severe OSA patients (age = 57...
2018: PloS One
Frédéric Aubrun, Noël Zahr, Olivier Langeron, Nicolas Boccheciampe, Nathalie Cozic, Lisa Belin, Jean-Sebastien Hulot, Frederic Khiami, Bruno Riou
BACKGROUND: Among the various factors that may influence the pharmacological response to opioids, genetic polymorphisms [single nucleotide polymorphisms (SNP)] have generated some interest. OBJECTIVES: To examine the influence on morphine dose requirements and adverse events in the postoperative period of four SNP [opioid receptor mu1 (OPRM1), ATP-binding cassette subfamily B, member 1 (ABCB1) ex-21 and ex-26, catechol-o-methyltransferase (COMT)] in candidate genes involved in morphine pharmacodynamics and pharmacokinetics...
February 22, 2018: European Journal of Anaesthesiology
Culadeeban Ratneswaran, Martino F Pengo, Sichang Xiao, Yuanming Luo, Gian Paolo Rossi, Michael I Polkey, John Moxham, Joerg Steier
OBJECTIVES: Continuous positive airway pressure (CPAP) improves upper airway obstruction in patients with obstructive sleep apnoea (OSA), who often are overweight-obese. Although it is thought that CPAP improves long-term blood pressure control (BP), the impact of acute and short-term CPAP use on the cardiovascular system in obese patients has not been described in detail. METHODS: Obese patients (body mass index, BMI > 25 kg/m2 ) with OSA were studied awake, supine during incremental CPAP titration (4-20 cmH2 O, +2 cmH2 O/3 mins)...
February 23, 2018: Blood Pressure
Isabelle Vivodtzev, Renaud Tamisier, Marilie Croteau, Jean-Christian Borel, Angélique Grangier, Bernard Wuyam, Patrick Lévy, Caroline Minville, Frédéric Sériès, François Maltais, Jean-Louis Pépin
BACKGROUND: Obstructive sleep apnoea (OSA) and obesity are interdependent chronic diseases sharing reduced exercise tolerance and high cardiovascular risk. INTERVENTION: A 3-month intervention with innovative training modalities would further improve functional capacity and cardiovascular health than usual cycle exercise training in already continuous positive airway pressure (CPAP)-treated obese patients with OSA. METHODS: Fifty three patients (35<body mass index (BMI) <45 kg/m2 ) were randomly allocated to exercise training on a cycle ergometer, either alone (ERGO) or with respiratory muscle training (ERGO+RMT) or non-invasive ventilation (ERGO+NIV)...
February 20, 2018: Thorax
L Pabla, J Duffin, L Flood, K Blackmore
BACKGROUND: Despite the plethora of publications on the subject of paediatric obstructive sleep apnoea, there seems to be wide variability in the literature and in practice, regarding recourse to surgery, the operation chosen, the benefits gained and post-operative management. This may reflect a lack of high-level evidence. METHODS: A systematic review of four significant controversies in paediatric ENT was conducted from the available literature: tonsillectomy versus tonsillotomy, focusing on the evidence base for each; anaesthetic considerations in paediatric obstructive sleep apnoea surgery; the objective evidence for the benefits of surgical treatment for obstructive sleep apnoea; and the medical treatment options for residual obstructive sleep apnoea after surgical treatment...
February 21, 2018: Journal of Laryngology and Otology
Shih-Wei Lin, Kate Sutherland, Yu-Fang Liao, Peter A Cistulli, Li-Pang Chuang, Yu-Ting Chou, Chih-Hao Chang, Chung-Shu Lee, Li-Fu Li, Ning-Hung Chen
BACKGROUND AND OBJECTIVE: Craniofacial structure is an important determinant of obstructive sleep apnoea (OSA) syndrome risk. Three-dimensional stereo-photogrammetry (3dMD) is a novel technique which allows quantification of the craniofacial profile. This study compares the facial images of OSA patients captured by 3dMD to three-dimensional computed tomography (3-D CT) and two-dimensional (2-D) digital photogrammetry. Measurements were correlated with indices of OSA severity. METHODS: Thirty-eight patients diagnosed with OSA were included, and digital photogrammetry, 3dMD and 3-D CT were performed...
February 20, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
S Lata, S K Mohanty, S Vinay, Abhaya Chandra Das, Sanjib Das, Priyadarshini Choudhury
This questioner survey aimed about awareness of the Cone Beam Computed Tomography (CBCT) machine and its various clinical applications in ENT, among the ENT surgeons in the state of Odisha. 150 questioner forms on CBCT were distributed to the all the participating ENT surgeons at a state level ENT conference, out of which the response rate was 110. The participants were asked to answer 30 multiple choice questions, which were divided into 3 parts; general information on CBCT, general approach to CBCT and practice related to CBCT...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
Tianyi Huang, Brian M Lin, Sarah C Markt, Meir J Stampfer, Francine Laden, Frank B Hu, Shelley S Tworoger, Susan Redline
Despite well-known male predominance in the prevalence of obstructive sleep apnoea (OSA), sex differences in the associations between OSA and a comprehensive range of epidemiologic factors remain less clear.We examined the prevalence of self-reported OSA in 143 326 women (age: 48-93) from the Nurses' Health Study (NHS) and NHSII and 22 896 men from the Health Professionals Follow-up Study (age: 65-101) in 2012-2013. Multivariable logistic regression was used to estimate the sex-specific prevalence odds ratios (pOR) and 95% CIs of OSA by demographic, anthropometric, lifestyle and co-morbidity factors...
February 15, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Cathy Zhang, Michelle Ramsay, Panagis Drakatos, Joerg Steier
Background: Patients with neuromuscular disease (NMD) are at risk of developing sleep-disordered breathing (SDB) with hypercapnic respiratory failure. We hypothesised that a self-administered questionnaire (SiNQ-5 scores) may be useful to assess patients who are established on treatment for NMD with SDB. Methods: Patients attending a tertiary referral centre filled in the SiNQ-5 (range 0-10 points, lower scores indicating fewer symptoms). The questionnaire contains five questions related to breathlessness, sleep and posture...
January 2018: Journal of Thoracic Disease
Jacques-Henri Meurgey, Richard Brown, Asia Woroszyl-Chrusciel, Joerg Steier
Background: Obstructive sleep apnoea (OSA) is increasingly common in bariatric patients undergoing sedation during elective surgery. However, it has not been established how significant a contributor it is to peri-operative respiratory complications and mortality. We sought to pre-operatively identify OSA in bariatric patients and record peri-operative complications during and after bariatric surgery. Methods: Data were collected and analysed from June 2014 to March 2017 for 410 bariatric surgery patients referred to the sleep laboratory for pre-operative screening and treatment of OSA...
January 2018: Journal of Thoracic Disease
Marina Florés, Montserrat Martinez-Alonso, Alicia Sánchezde-la-Torre, Albina Aldomà, Estefania Galera, Ferran Barbé, Manuel Sánchezde-la-Torre, Mireia Dalmases
Background: Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnoea (OSA), but an evaluation of CPAP adherence is rarely carried out among patients with acute coronary syndrome (ACS). The goals of the study are to analyse long-term adherence and identify the predictors of non-compliance with CPAP treatment for patients with non-sleepy OSA and ACS. Methods: This is an ancillary study of the ISAACC study, which is a multicentre, prospective, open-label, parallel, randomized, and controlled trial (NCT01335087) in patients with hospital admission for ACS...
January 2018: Journal of Thoracic Disease
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