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Obstructive Sleep Apnoea

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https://www.readbyqxmd.com/read/28738368/updated-minimally-invasive-surgery-for-sleep-related-breathing-disorders
#1
Bhik Kotecha
Sleep-related breathing disorders (SRBD) consist of a variety of clinical entities, ranging from primary snoring to severe obstructive sleep apnoea at the opposite extreme. Although it has no official definition, minimally invasive surgery infers surgery where the procedure is clinically less aggressive and may involve a much smaller incision or none at all. It also implies that such procedures may result in a quicker recovery and reduced morbidity, and that they are often conducted under local anaesthesia as day cases...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28736115/three-dimensional-volumetric-changes-in-the-upper-airway-after-maxillomandibular-advancement-in-obstructive-sleep-apnoea-patients-and-the-impact-on-quality-of-life
#2
B Veys, L Pottel, W Mollemans, J Abeloos, G Swennen, N Neyt
Obstructive sleep apnoea (OSA) is a sleep-related breathing disorder, characterized by repetitive airway obstructions, causing disruptive snoring and daytime sleepiness. Maxillomandibular advancement (MMA), which enlarges the upper airway, is a therapeutic surgical approach. However, no study has performed an upper airway sub-region analysis using validated three-dimensional (3D) anatomical and technical limits on cone beam computed tomography (CBCT). Hence, this prospective, observational trial was performed to evaluate 3D volumetric changes in the upper airway according to validated 3D cephalometric landmarks, before and after MMA, for all patients with a polysomnography diagnosis of OSA (apnoea-hypopnoea index (AHI) ≥5)...
July 20, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28735907/the-relationship-between-weight-change-and-daytime-sleepiness-the-sleep-heart-health-study
#3
Winda L Ng, Liliana Orellana, Jonathan E Shaw, Evelyn Wong, Anna Peeters
OBJECTIVE: Through a causal framework, we aim to assess the association between weight change and daytime sleepiness, and the role of obstructive sleep apnoea (OSA) in this relationship. METHODS: From the Sleep Heart Health Study, we selected individuals who were: (1) 40-64 years old, with (2) body mass index (BMI) ≥18.5 kg/m(2), (3) no history of stroke, treatment for OSA, and tracheostomy at baseline. We used multiple linear regression to assess the relationship between five-year weight change and daytime sleepiness (assessed through Epworth Sleepiness Scale (ESS)) at five years, adjusting for daytime sleepiness, demographics, diabetes, subjective sleep duration, sleep disturbance, smoking status, weight, and use of antidepressants and benzodiazepines at baseline, in those with complete data (N = 1468)...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28734850/progression-and-reversibility-of-stretch-induced-atrial-remodeling-characterization-and-clinical-implications
#4
REVIEW
Shivshankar Thanigaimani, Emma McLennan, Dominik Linz, Rajiv Mahajan, Thomas A Agbaedeng, Geoffrey Lee, Jonathan M Kalman, Prashanthan Sanders, Dennis H Lau
Atrial fibrillation (AF) is the most common sustained arrhythmia and across the developed nations, it contributes to increasing hospitalizations and healthcare burden. Several comorbidities and risk factors including hypertension, heart failure, obstructive sleep apnoea and obesity are known to play an important role in the initiation and perpetuation of AF and atrial stretch or dilatation may play a central mechanistic role. The impact of atrial stretch in the development of AF can vary dependent on the underlying disease...
July 19, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28730908/electrical-stimulation-for-the-treatment-of-obstructive-sleep-apnoea-a-review-of-the-evidence
#5
Valeria Bisogni, Martino F Pengo, Andrea De Vito, Giuseppe Maiolino, Gian Paolo Rossi, John Moxham, Joerg Steier
Obstructi ve sleep apnoea is an increasingly prevalent clinical condition with significant impact on individuals and public health. Continuous positive airway pressure therapy is the standard treatment, but adherence is limited and alternative treatments are needed. In this context, non-invasive and invasive methods for the electrical stimulation of upper airway dilator muscles have been demonstrated to be effective in selected patients. Areas covered: This review will cover investigations on the clinical effects, safety, and tolerability of non-invasive and invasive electrical stimulation of the upper airway for the management of obstructive sleep apnoea...
July 21, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28730724/dynamic-loop-gain-increases-upon-adopting-the-supine-body-position-during-sleep-in-patients-with-obstructive-sleep-apnoea
#6
Simon A Joosten, Shane A Landry, Scott A Sands, Philip I Terrill, Dwayne Mann, Christopher Andara, Elizabeth Skuza, Anthony Turton, Philip Berger, Garun S Hamilton, Bradley A Edwards
BACKGROUND AND OBJECTIVE: Obstructive sleep apnoea (OSA) is typically worse in the supine versus lateral sleeping position. One potential factor driving this observation is a decrease in lung volume in the supine position which is expected by theory to increase a key OSA pathogenic factor: dynamic ventilatory control instability (i.e. loop gain). We aimed to quantify dynamic loop gain in OSA patients in the lateral and supine positions, and to explore the relationship between change in dynamic loop gain and change in lung volume with position...
July 20, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28718463/-chewing-on-bruxism-associations-consequences-and-management
#7
F Lobbezoo, R Jacobs, A DE Laat, G Aarab, P Wetselaar, D Manfredini
In this second part of a diptych on bruxism, the focus is on the associations of this masticatory muscle activity with other sleep-related conditions. Its association with the obstructive sleep apnoea syndrome (OSAS) has been a particular object of study. Bruxism seems to play a protective role in OSAS, although the evidence for this is not yet conclusive. Apart from this possible positive consequence, bruxism also has several negative consequences, for which evidence is available to a greater or lesser extent...
July 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28717285/orthognathic-surgery-a-review-of-articles-published-in-2014-2015
#8
REVIEW
Vaibhav Singh, K N V Sudhakar, Rajat Mohanty, Suravi Chatterjee
OBJECTIVES: We did a retrospective study and reviewed some of the orthognathic surgery related papers that were published between January 2014 and December 2015 in a leading International Maxillofacial Surgery Journal. It was conducted to ascertain the trends of articles being published. METHOD: A total of around 57 articles were reviewed, of which most of the full length articles were on post operative outcomes and obstructive sleep apnoea. RESULTS: Bulk of the studies were retrospective, and less interest was shown onto experimental researches...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28702830/sleep-disordered-breathing-in-patients-with-neuromuscular-disease
#9
REVIEW
Mohamad Ammar Albdewi, Giuseppe Liistro, Riëm El Tahry
Sleep-disordered breathing (SDB) is relatively common in general population as well as in patients with neuromuscular disease. SDB comprises a wide spectrum of disorders varying from simple snoring to complete closure of the upper airway as seen in obstructive sleep apnoea (OSA). It includes also other disorders like prolonged hypoxemia, hypoventilation, and central sleep apnoea (CSA). Neuromuscular diseases (NMD) form a group of disorders that can cause significant reduction in the quality and span of life...
July 12, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28697288/obstructive-sleep-apnoea-and-obesity
#10
Garun S Hamilton, Simon A Joosten
BACKGROUND: Obstructive sleep apnoea (OSA) and obesity are two common conditions affecting the Australian population; obesity is the major risk factor for OSA. OBJECTIVE: The objectives of this article are to review the interactions between obesity and OSA, including the increased cardiovascular risk, and highlight the importance of using OSA diagnosis as a critical time to address obesity itself and other cardiovascular risk factors. DISCUSSION: Snoring and symptoms of OSA frequently worsen during periods of rapid weight gain...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28684302/assessment-of-obstructive-sleep-apnoea-treatment-success-or-failure-after-maxillomandibular-advancement
#11
M H T de Ruiter, R C Apperloo, D M J Milstein, J de Lange
Maxillomandibular advancement (MMA) is an alternative therapeutic option that is highly effective for treating obstructive sleep apnoea (OSA). MMA provides a solution for OSA patients that have difficulty accepting lifelong treatments with continuous positive airway pressure or mandibular advancement devices. The goal of this study was to investigate the different characteristics that determine OSA treatment success/failure after MMA. The apnoea-hypopnoea index (AHI) was used to determine the success or failure of OSA treatment after MMA...
July 3, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28677827/the-overlaps-of-asthma-or-copd-with-osa-a-focused-review
#12
REVIEW
Robert L Owens, Madalina M Macrea, Mihaela Teodorescu
Asthma, chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea (OSA) are the most common respiratory disorders worldwide. Given demographic and environmental changes, prevalence for each is likely to increase. Although exact numbers are not known, based on chance alone, many people will be affected by both lower airways obstruction and concomitant upper airway obstruction during sleep. Some recent studies suggest that there is a reciprocal interaction, with chronic lung disease predisposing to OSA, and OSA worsening control and outcomes from chronic lung disease...
July 5, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28677369/propofol-attenuates-intermittent-hypoxia-induced-up-regulation-of-proinflammatory-cytokines-in-microglia-through-inhibiting-the-activation-of-nf-b%C3%AE%C2%BA-p38-mapk-signalling
#13
Song Liu, Jin-Yuan Sun, Lian-Ping Ren, Kui Chen, Bo Xu
<i>As immune sentinels of the central nervous system (CNS), microglia is pivotal cellular mediator of neuroinflammatory processes. Activation of microglia might elicit the expression of proinflammatory cytokines involved in the progression of neuroinflammatory diseases. Numerous studies have demonstrated that propofol (2,6-diisopropylphenol) has an effective anti-inflammatory property. Intermittent hypoxia (IH), as a result of obstructive sleep apnoea (OSA), could lead to neuron damage and neuroinflammation in the CNS...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28675190/feasibility-of-a-respiratory-nurse-specialist-led-sleep-disorder-service-in-a-district-general-hospital
#14
D M Comer
Aim The burden of referrals to investigate sleep disorders has escalated considerably. In order to address this, the feasibility of a nurse-led sleep disorder clinic was investigated. Methods Sleep referrals were stratified on the basis of information contained within the primary care referral, and appropriate home-based sleep studies arranged if obstructive sleep apnoea was considered the most likely working diagnosis. Selected patients were started on continuous positive airway pressure treatment if deemed appropriate...
June 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28673378/newly-diagnosed-obstructive-sleep-apnoea-and-type-2-diabetes-mellitus
#15
Anne Roed Jacobsen, Freja Eriksen, Line Thorup, Lykke Bennedsen Skødeberg, Jonas Peter Yde Holm, Klavs Wörgler Hansen
INTRODUCTION: Obstructive sleep apnoea (OSA) is frequent in type 2 diabetes mellitus (DM) and is seen in 12-30% of patients with newly diagnosed OSA according to previous studies. Our aim was to determine the referral pattern and prevalence of patients with self-reported type 2 DM in a Danish cohort of patients with newly diagnosed OSA. Furthermore, we compared clinical data related to the sleep disorder in patients with and without type 2 DM and different OSA severities. METHODS: This retrospective observational study was based on data from a cohort including all patients offered continuous positive airway pressure therapy in the course of a 14-month period after being referred to a sleep disorders clinic...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28667231/educational-video-to-improve-cpap-use-in-patients-with-obstructive-sleep-apnoea-at-risk-for-poor-adherence-a-randomised-controlled-trial
#16
Amy S Guralnick, Jay S Balachandran, Shane Szutenbach, Kevin Adley, Leila Emami, Meelad Mohammadi, Jeanne M Farnan, Vineet M Arora, Babak Mokhlesi
BACKGROUND: Suboptimal adherence to CPAP limits its clinical effectiveness in patients with obstructive sleep apnoea (OSA). Although rigorous behavioural interventions improve CPAP adherence, their labour-intensive nature has limited widespread implementation. Moreover, these interventions have not been tested in patients at risk of poor CPAP adherence. Our objective was to determine whether an educational video will improve CPAP adherence in patients at risk of poor CPAP adherence. METHODS: Patients referred by clinicians without sleep medicine expertise to an urban sleep laboratory that serves predominantly minority population were randomised to view an educational video about OSA and CPAP therapy before the polysomnogram, or to usual care...
June 30, 2017: Thorax
https://www.readbyqxmd.com/read/28667213/extrapulmonary-effects-of-continuous-airway-pressure-on-patients-with-obstructive-sleep-apnoea-protocol-for-an-overview-of-systematic-reviews
#17
Gonzalo Labarca, Francisco Ortega, Alex Arenas, Tomas Reyes, Gabriel Rada, Jorge Jorquera
INTRODUCTION: Obstructive sleep apnoea (OSA) is associated with both pulmonary and extrapulmonary consequences. Continuous positive airway pressure (CPAP) is an effective treatment for pulmonary symptoms. However, it is not clear if CPAP modifies extrapulmonary symptoms, especially in the long term. To date, several studies addressing this issue have been performed, but the evidence is scattered across different reviews that address each outcome separately. Therefore, we will conduct an overview to assess and summarise all systematic reviews on the extrapulmonary effects of this intervention in patients with OSA...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28663598/cost-effectiveness-strategies-in-osas-management-a-short-review
#18
D M Toraldo, D Passali, A Sanna, F De Nuccio, L Conte, M De Benedetto
Obstructive sleep apnoea (OSAS) is an underdiagnosed chronic disease with a high prevalence in adults. It is becoming a significant social problem, since it is associated with a worsening in quality of life and increase in mortality. The cost-effectiveness ratio of diagnostic and therapeutic management of OSAS is a strategic issue to counteract the expected increasing demand of objective testing. OSAS patients with any clinical evidence of comorbidities must be studied using simplified and less expensive systems such as Home Sleep Testing (HST)...
June 30, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28662919/risk-factor-management-and-atrial-fibrillation-clinics-saving-the-best-for-last
#19
REVIEW
Rajiv Mahajan, Rajeev K Pathak, Anand Thiyagarajah, Dennis H Lau, Francis E Marchlinski, Sanjay Dixit, John D Day, Jeroen M L Hendriks, Melinda Carrington, Jonathan M Kalman, Prashanthan Sanders
Atrial fibrillation (AF) is a leading cause of cardiovascular morbidity and mortality worldwide. Management of AF is a complex process involving: 1) the prevention of thromboembolic complications with anticoagulation; 2) rhythm control; and 3) the detection and treatment of underlying heart disease. However, cardiometabolic risk factors, such as obesity, hypertension, diabetes mellitus, and obstructive sleep apnoea, have been proposed as contributors to the expanding epidemic of atrial fibrillation (AF). Thus, a fourth pillar of AF care would include aggressive targeting of interdependent, modifiable cardiovascular risk factors as part of an integrated care model...
June 9, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28662007/-evaluation-of-sleep-apnea-detected-by-24-hour-ecg-holter-monitoring-analysis-in-patients-with-stable-coronary-artery-disease-and-ischemic-heart-failure-correlations-with-clinical-data
#20
Magdalena Frączek-Jucha, Paweł Rostoff, Jacek Łach, Jadwiga Nessler, Andrzej Gackowski
Obstructive sleep apnoea (OSA) is frequently undiagnosed in patients with heart failure (HF) and coronary artery disease (CAD). Simple and widely available screening tests are needed to diagnose patients with SA. Measurements of thoracic impedance and heart rate variability during 24-hour ECG Holter (H-EKG) monitoring allows to calculate estimated apnoea-hypopnoea index (eAHI). AIM: The aim of the research was to assess prevalence of OSA evaluated with the use of H-EKG and determination of its clinical relevance in patients with CAD and ischeamic HF...
June 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
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