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Cardiac markers

Alexandra Stoica, Victoriţa Şorodoc, Cătălina Lionte, Irina M Jaba, Irina Costache, Ecaterina Anisie, Cristina Tuchiluș, Ovidiu Rusalim Petriș, Oana Sîrbu, Elisabeta Jaba, Alexandr Ceasovschih, Luminiţa Vâţă, Laurenţiu Şorodoc
Objective This study was performed to determine whether a dual-biomarker approach using N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and galectin-3 optimizes the diagnosis and risk stratification of acute cardiac dyspnea. Atypical clinical manifestations and overlapping pathologies require objective and effective diagnostic methods to avoid treatment delays. Methods This prospective observational study included 208 patients who presented to the emergency department for acute dyspnea. NT-proBNP and galectin-3 were measured upon admission...
September 17, 2018: Journal of International Medical Research
Kathy Jacyniak, Matthew K Vickaryous
Although the contractile function of the heart is universally conserved, the organ itself varies in structure across species. This variation includes the number of ventricular chambers (one, two, or an incompletely divided chamber), the structure of the myocardial wall (compact or trabeculated), and the proliferative capacity of the resident cardiomyocytes. Whereas zebrafish is capable of comparatively high rates of constitutive cardiomyocyte proliferation, humans and rodents are not. However, for most species, the capacity to generate new cardiomyocytes under homeostatic conditions remains unclear...
September 17, 2018: Journal of Morphology
Lin Huang, Ping Yuan, Peng Yu, Qiling Kong, Zixuan Xu, Xia Yan, Yang Shen, Juesheng Yang, Rong Wan, Kui Hong, Yanhua Tang, Jinzhu Hu
The O‑linked β‑N‑acetylglucosamine (O‑GlcNAc) modification and autophagy are associated with diabetic myocardial injury, however, the molecular mechanisms between the two processes remain to be fully elucidated. The purpose of the present study was to elucidate the molecular regulation of autophagy by O‑GlcNAc‑modified synaptosomal‑associated protein 29 (SNAP29) in diabetic myocardial injury. A rat model of type I diabetes was established via intraperitoneal injection of streptozotocin (STZ; 55 mg/kg)...
September 7, 2018: International Journal of Molecular Medicine
Andrew Poklepovic, Yuesheng Qu, Molly Dickinson, Michael C Kontos, Maciej Kmieciak, Elizabeth Schultz, Dipankar Bandopadhyay, Xiaoyan Deng, Rakesh C Kukreja
Background: Doxorubicin chemotherapy is used across a range of adult and pediatric malignancies. Cardiac toxicity is common, and dysfunction develops over time in many patients. Biomarkers used for predicting late cardiac dysfunction following doxorubicin exposure have shown promise. Preclinical studies have demonstrated potential cardioprotective effects of sildenafil. Methods: We sought to confirm the safety of adding sildenafil to doxorubicin-based chemotherapy and assess N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) and high sensitivity cardiac troponin I (hsTnI) as early markers of anthracycline-induced cardiotoxicity...
2018: Cardio-Oncology
Catherine Mary Hill, Romola Starr Bucks, Nicola Cellini, Shayan Motamedi, Annette Carroll, Kate Heathcote, Rebecca Webster, David Simpson
Study Objectives: We aimed to characterize heart rate variability (HRV) during sleep in Andean children native to high altitude (HA) compared to age, gender and genetic ancestry-similar low altitude (LA) children. We hypothesized that the hypoxic burden of sleep at HA could induce variation in HRV. As children have otherwise healthy cardiovascular systems, such alterations could provide early markers of later cardiovascular disease. Methods: Twenty-six LA (14F) and 18 HA (8F) children underwent a single night of attended polysomnography...
September 13, 2018: Sleep
Benedetta Ermon, Claudia B Volpato, Giada Cattelan, Rosamaria Silipigni, Marina Di Segni, Chiara Cantaloni, Michela Casella, Peter P Pramstaller, Giulio Pompilio, Elena Sommariva, Viviana Meraviglia, Alessandra Rossini
Arrhythmogenic Cardiomyopathy (ACM) is an inherited cardiac disease characterized by arrhythmias and fibro-fatty replacement in the ventricular myocardium. Causative mutations are mainly reported in desmosomal genes, especially in plakophilin2 (PKP2). Here, using a virus-free reprogramming approach, we generated induced pluripotent stem cells (iPSCs) from skin fibroblasts of one ACM patient carrying the frameshift heterozygous PKP2 mutation c.2569_3018del50. The iPSC line (EURACi004-A) showed the typical morphology of pluripotent cells, possessed normal karyotype and exhibited pluripotency markers and trilineage differentiation potential, including cardiomyogenic capability...
September 6, 2018: Stem Cell Research
Laura A Adang, David B Frank, Ahmed Gilani, Asako Takanohashi, Nicole Ulrick, Abigail Collins, Zachary Cross, Csaba Galambos, Guy Helman, Usama Kanaan, Stephanie Keller, Dawn Simon, Omar Sherbini, Brian D Hanna, Adeline L Vanderver
While pulmonary hypertension (PH) is a potentially life threatening complication of many inflammatory conditions, an association between Aicardi Goutières syndrome (AGS), a rare genetic cause of interferon (IFN) overproduction, and the development of PH has not been characterized to date. We analyzed the cardiac function of individuals with AGS enrolled in the Myelin Disorders Bioregistry Project using retrospective chart review (n = 61). Additional prospective echocardiograms were obtained when possible (n = 22)...
September 7, 2018: Molecular Genetics and Metabolism
Gabriel Barros Rodrigues, Elquio Eleamen Oliveira, Francisco Jaime Bezerra Mendonça Junior, Laise Aline Martins Dos Santos, Wilma Helena de Oliveira, Maria Eduarda Rocha de França, Deniele Bezerra Lós, Brennda Martins Gabínio, Christina Alves Peixoto
The aim of the present study was to assess if the uninterrupted and prolonged administration of nanoparticles containing diethylcarbamazine (NANO-DEC) would cause liver, kidney and heart toxicity and then analyze for the first time its action in model of liver fibrosis. Thus, NANO-DEC was administered in C57BL/6 mice daily for 48 days, and at the end the blood was collected for biochemical analyzes. In the long-term administration assay, the evaluation of serological parameters (CK-MB, creatinine, ALT, AST and urea) allowed the conclusion that NANO-DEC prolonged administration did not cause hepatic, renal and cardiac damage...
September 13, 2018: International Immunopharmacology
Frank E Corrigan, John H Chen, Aneel Maini, John C Lisko, Lucia Alvarez, Norihiko Kamioka, Shawn Reginauld, Patrick T Gleason, Jose F Condado, Jane Wenjing Wei, Jose N Binongo, Patricia Keegan, Sharon Howell, Vinod H Thourani, Peter C Block, Stephen D Clements, Vasilis C Babaliaros, Stamatios Lerakis
OBJECTIVES: In this study, the authors hypothesized that intraprocedural improvement of pulmonary venous (PV) waveforms are predictive of improved outcomes. In this report, they analyzed intraprocedural invasive and echocardiographic changes with respect to rehospitalization and mortality. BACKGROUND: The effects of hemodynamic changes during percutaneous mitral valve repair (PMVR) with MitraClip (Abbott Vascular, Santa Clara, California) are incompletely characterized...
September 6, 2018: JACC. Cardiovascular Imaging
Sebastien Hascoët, Khaled Hadeed, Clement Karsenty, Yves Dulac, Francois Heitz, Nicolas Combes, Gerald Chausseray, Xavier Alacoque, Francoise Auriol, Pascal Amedro, Alain Fraisse, Philippe Acar
BACKGROUND: Imaging fusion between echocardiography and fluoroscopy was recently developed. The aim of this study was to assess its feasibility and accuracy during pediatric cardiac catheterization. METHODS: Thirty-one patients (median weight, 26 kg; interquartile range [IQR], 21-37 kg) who underwent percutaneous atrial septal defect closure were prospectively included. The feasibility and accuracy of various imaging fusion modalities (live two-dimensional, live color two-dimensional, live three-dimensional and markers) with EchoNavigator software were assessed...
September 12, 2018: Journal of the American Society of Echocardiography
Sharda S Anroedh, K Martijn Akkerhuis, Rohit M Oemrawsingh, Hector M Garcia-Garcia, Milos Brankovic, Evelyn Regar, Robert-Jan van Geuns, Patrick W Serruys, Joost Daemen, Nicolas M van Mieghem, Eric Boersma, Isabella Kardys
PURPOSE OF REVIEW: The purpose of this study was to investigate the association of 26 inflammatory biomarkers (acute phase proteins, cytokines, chemokines) and renal markers with coronary lipid core burden index (LCBI) assessed by near-infrared spectroscopy (NIRS) imaging, as well as the association of these biomarkers with long-term cardiovascular outcome. RECENT FINDINGS: NIRS-derived LCBI has recently been shown to be an independent predictor of major adverse cardiac events (MACE)...
September 14, 2018: Current Atherosclerosis Reports
Stephen B Heitner, Jessica Minnier, Aynun Naher, Ryan Van Woerkem, Alexandra Ritts, Maros Ferencik, Craig Broberg, Eva Medvedova, Rebecca Silbermann, Emma C Scott
BACKGROUND: Proteasome inhibitors used in the treatment of multiple myeloma act primarily through the disruption of intrinsic cellular protein quality maintenance, resulting in proteotoxic stress, cellular dysfunction, and, ultimately, cell death. We assessed whether evidence has shown off-target myocardial dysfunction related to the administration of bortezomib-based chemotherapy for multiple myeloma. PATIENTS AND METHODS: Patients aged 18 to 70 years who were free of significant cardiovascular disease were included...
August 14, 2018: Clinical Lymphoma, Myeloma & Leukemia
Daniel Musikant, Hugo Sato, Evangelina Capobianco, Verónica White, Alicia Jawerbaum, Romina Higa
Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well as the role of forkhead box transcription factor 1 (FOXO1) in the induction of these alterations. The heart from adult offspring from control and streptozotocin-induced diabetic rats was evaluated. Increased glycemia, triglyceridemia and insulinemia and markers of cardiomyopathy were found in the offspring from diabetic rats...
September 11, 2018: Molecular and Cellular Endocrinology
Benoit Lattuca, Vuthy Sy, Lee Nguyen, Maguy Bernard, Michel Zeitouni, Pavel Overtchouk, Yan Yan, Nadjib Hammoudi, Alexandre Ceccaldi, Jean-Philippe Collet, Mathieu Kerneis, Abdourahmane Diallo, Gilles Montalescot, Johanne Silvain
BACKGROUND: Copeptin - the C-terminal section of vasopressin precursor - is a novel biomarker, that has been shown to be a useful prognostic factor in heart failure, ischemic stroke and in acute myocardial infarction (MI) but with restricted population and follow-up in ST-segment elevation MI (STEMI) setting. We evaluated in this study the hypothesis that copeptin measured on admission is an independent predictor of one-year all-cause mortality after a STEMI. METHODS: Copeptin was measured immediately on arrival in the catheterization laboratory in a cohort of unselected STEMI patients and was compared to the peak of cardiac troponin I as a prognosis marker...
September 6, 2018: International Journal of Cardiology
Rakan I Nazer, Mohammed F Abalhassan, Khalid A Alburikan
Background: Metformin is an oral antidiabetic agent belonging to the biguanide class of antidiabetics. Possible novel applications for metformin in cardiovascular disease might exist. The aim of this study was to verify a possible association between pre-operative metformin administration and protection against ischemia-induced liver injury in diabetic patients undergoing coronary artery bypass grafting (CABG) surgery. Methods: A retrospective case-control series was conducted at a single center...
August 2018: Cardiovascular Diagnosis and Therapy
Reham F El-Kased
Cardiac troponin-I is a promising diagnostic marker for cardiovascular diseases. Troponin-I immunoassays rely on monoclonal antibodies, while polyclonal antibodies, cheaper to manufacture, are uncommonly used. The current study established an immuno-analytical assay using a polyclonal antibody capable of mapping troponin-I antigenic determinant. Proteolytic digestion of troponin-I was performed. Antigenic determinant was assigned by separation of fragments using gel electrophoresis followed by Western blot and high-performance liquid chromatography followed by dot blot...
September 13, 2018: Journal of Immunoassay & Immunochemistry
Zhi-Min Wang, Meng-Jun Wang, Xiao-Fan Hu, Ya-Kun Li, Dong-Xia Ma, Shang-Lin Li, Guang-Yuan Zhao, Ya-Nan Xie, Yan-Wen Shu, Jun Yang
BACKGROUND: Advances in immunosuppressive therapy have significantly improved short-term but not long-term survival of cardiac transplant recipients; this is largely due to severe cardiac allograft vasculopathy (CAV). Glucagon-like peptide-1 receptor (GLP-1R)-based therapy exerts physiological effects on the cardiovascular system in addition to its traditional role in controlling glucose. We have investigated the effects of liraglutide, a GLP-1R agonist, on the development of CAV in a murine heart transplant model...
September 10, 2018: Transplantation
Clemens M Ortner, Vijay Krishnamoorthy, Elmari Neethling, Margot Flint, Justiaan L Swanevelder, Carl Lombard, Susan Fawcus, Robert A Dyer
BACKGROUND: Pilot studies applying point-of-care ultrasound (POCUS) in preeclampsia indicate the presence of pulmonary interstitial edema, cerebral edema, and cardiac dysfunction. Laboratory markers of oncotic pressure (albumin) and cardiac dysfunction (brain natriuretic peptide [BNP]) may be abnormal, but the clinical application remains unclear. We investigated the prevalence of pulmonary interstitial syndrome (PIS), cardiac dysfunction, and increased optic nerve sheath diameter (ONSD) in late-onset preeclampsia with severe features...
September 10, 2018: Anesthesia and Analgesia
Anjali M Prabhat, M Lakshmi Kuppusamy, Shan K Naidu, Sarath Meduru, Praneeth T Reddy, Abishai Dominic, Mahmood Khan, Brian K Rivera, Periannan Kuppusamy
Myocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If left untreated, MI will lead to progressive loss of viable cardiomyocytes, deterioration of cardiac function, and congestive heart failure. While supplemental oxygen therapy has long been in practice to treat acute MI, there has not been a clear scientific basis for the observed beneficial effects. Further, there is no rationale for the amount or duration of administration of supplemental oxygenation for effective therapy...
2018: Frontiers in Cardiovascular Medicine
Zhuzhi Wen, Zun Mai, Yangxin Chen, Jingfeng Wang, Dengfeng Geng
The present study aimed to test whether angiotensin receptor blockers (ARBs) are cardioprotective after myocardial infarction (MI) by preventing augmented local renin-angiotensin-system (RAS)-induced oxidative stress injury and senescence, preserving resident stem cells, and restoring the insulin-like growth factor (IGF-1)/IGF-1 receptor (IGF-R) pathway. Sprague-Dawley rats with ligated or unligated coronary arteries were treated with losartan (20 mg/kg/d) or vehicle for 3 or 9 weeks. Heart function and molecular and histological changes were assessed...
2018: American Journal of Translational Research
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