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Cardiac markers

Lian Duan, Levent Yobas
We introduce an integrated array of glass nanopores on a silicon microchip fabricated in a batch process through low-resolution photolithography and standard semiconductor processing tools. By functionalizing each nanopore against a distinct target, we further demonstrate ultrasensitive, label-free, multiplexed electrical detection of cancer-marker proteins in real time through charge-dependent ionic current rectification. As nanofluidic diode biosensors, the nanopores return rapid results with a limit of detection reaching concentrations as low as attomolars in assay buffer and femtomolars in undiluted untreated human serum, a rare achievement for this class of nanosensors...
July 19, 2018: ACS Nano
Abdulselam İlter, Eyyup Tusun, Abdullah Cirit
Coronary-cameral fistula (CCF) is a rare connection between a coronary artery and a chamber of the heart. It most often derives from the right coronary artery and drains into the right ventricle. CCF originating from all 3 major coronary vessels and draining into the left heart is an extremely rare coronary artery malformation. A 47-yearold-man who was admitted to the clinic with angina pectoris and positive cardiac markers suddenly developed ventricular fibrillation (VF) while being prepared for coronary catheterization...
July 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Goltaj Bayrami, Alireza Alihemmati, Pouran Karimi, Aniseh Javadi, Rana Keyhanmanesh, Mustafa Mohammadi, Milad Zadi-Heydarabad, Reza Badalzadeh
Purpose: Diabetic hearts are resistant to cardioprotection by ischemic-postconditioning (IPostC). Protection of diabetic hearts and finding related interfering mechanisms would have clinical benefits. This study investigated the combination effects of vildagliptin (Vilda) and IPostC on cardioprotection and the levels of autophagy and mitochondrial function following myocardial ischemia/reperfusion (I/R) injury in type-II diabetic rats. Methods: Diabetes was established by high fat diet/low dose of streptozotocin and lasted for 12 weeks...
June 2018: Advanced Pharmaceutical Bulletin
Hanan Hassan Sabry, Jehan Hassan Sabry, Aliaa El Husseiny Daifalla, Essam Mohamed Akl, Ahmed Mohamed Hamed, Ahmed Abd Allah Torky
Background: The aim of the study was to measure serum levels of endocan, myeloperoxidase (MPO), pentraxin 3 (PTX3) and 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ) in psoriatic patients and to study their correlations with carotid intima-media thickness (CIMT) in trial to evaluate predictability of these parameters in diagnosing asymptomatic atherosclerosis (AAS). Patients and methods: Seventy-five psoriasis patients and 75 control subjects underwent complete clinical examination and Doppler estimation of CIMT using thickness of 0...
2018: Vascular Health and Risk Management
Sung Wook Um, Robert Ohle, Jeffrey J Perry
INTRODUCTION: Interarm systolic BP differential is a classic sign of acute aortic dissection (AAD). All previous studies looking at the association of BP differential with AAD combine systolic BP differential >20 mm Hg with pulse deficit. Our aim was to assess the association of systolic BP differential with AAD, and its role in predicting AAD in the context of other signs and symptoms. METHODS: Historical matched case-control study using patient data collected between 2002 and 2014: participants were adults >18 years old with a bilateral BP measurement presenting to two tertiary care EDs or one regional cardiac referral centre in Canada...
July 18, 2018: Emergency Medicine Journal: EMJ
Rajeev K Pathak, Prashanthan Sanders, Rajat Deo
Sudden cardiac death (SCD) accounts for approximately one-third of all deaths among patients with non-ischaemic cardiomyopathy (NICM). Implantable cardioverter-defibrillator (ICD) therapy has been the primary intervention for managing individuals at high risk for SCD. However, individual ICD trials in the NICM population have failed to demonstrate a mortality benefit with prophylactic ICD implantation. Current guidelines recommend ICD implantation in NICM patients with symptomatic heart failure and a left ventricular ≤35% and are based on meta-analyses of multiple trials that span three decades and include the recent Danish Study to Assess the Efficacy of ICDs in Patients with Non-ischaemic Heart Failure on Mortality (DANISH) trial...
July 17, 2018: European Heart Journal
Ronald A Kahn, Anelechi Anyanwu
BACKGROUND: Cerebral near-infrared spectroscopy (NIRS) of tissue oxygen saturation is claimed to be a surrogate marker for global cerebral perfusion. Increasingly, NIRS target-based therapy has been used during cardiac surgery in the hope of decreasing the incidence of adverse neurological outcome. OBJECTIVES: We report NIRS values for some common vegetables and faculty at a world-class medical institution. DESIGN: Observational nonblinded study...
July 16, 2018: European Journal of Anaesthesiology
Noppadol Aroonyadet, Wutthinan Jeamsaksiri, Anurat Wisitsoraat, Adisorn Tuantranont
We report a scalable, uniform, and sensitive top-down fabricated indium oxide (In<sub>2</sub>O<sub>3</sub>) nanoribbon biosensor platform with integrated on-chip gate electrodes using two photolithographic masks. The purpose of this on-chip gate electrode is to control the operational point of the sensor during biomolecular detection replacing the cumbersome external Ag/AgCl electrode. It exhibits excellent capability in gating transistors in an aqueous condition and high stability during the sensing experiment, which is similar to the Ag/AgCl electrode...
July 18, 2018: Nanotechnology
Maria N Sanz, Emilie Farine, Petra Niederberger, Natalia Méndez-Carmona, Rahel K Wyss, Maria Arnold, Patrik Gulac, Georg M Fiedler, Mélanie Gressette, Anne Garnier, Thierry P Carrel, Hendrik T Tevaearai Stahel, Sarah L Longnus
Donation after circulatory death (DCD) holds great promise for improving cardiac graft availability, however concerns persist regarding injury following warm ischemia, after donor circulatory arrest, and subsequent reperfusion. Application of pre-ischemic treatments is limited for ethical reasons, thus cardioprotective strategies applied at graft procurement (reperfusion) are of particular importance in optimizing graft quality. Given the key role of mitochondria in cardiac ischemia-reperfusion injury, we hypothesize that three reperfusion strategies: mild hypothermia, mechanical post-conditioning and hypoxia, when briefly applied at reperfusion onset, provoke mitochondrial changes that may underlie their cardioprotective effects...
July 18, 2018: American Journal of Transplantation
Wei Gong, Youcai Ma, Aobo Li, Shi Han, Shaoping Nie
BACKGROUND/AIMS: Cardiac rupture (CR) is a catastrophic complication of acute myocardial infarction (MI). At present, there are no effective pharmacological strategies for preventing post-MI rupture. Here we investigated the effect of trimetazidine (TMZ) on post-MI CR. METHODS: MI models were induced by left coronary artery ligation in male C57BL/6 mice. Animals allocated to the rupture incidence were closely monitored for 7 days; autopsy was performed once animals were found dead to determine the reason of death...
July 17, 2018: Cardiovascular Therapeutics
Nina Zaproudina, Jukka A Lipponen, Mika P Tarvainen, Anu Vierola, Saara M Rissanen, Pasi A Karjalainen, Matti Närhi
BACKGROUND: Systemic autonomic changes are well-known in migraineurs. Also, masticatory dysfunctions including tooth clenching are reported to be associated with migraine. However, if those phenomena are interrelated, and how, is unclear. Moreover, the knowledge on the autonomic responses to masticatory stimuli in migraineurs is limited. OBJECTIVE: To investigate tooth clenching-related cardiac autonomic regulation in migraineurs. METHODS: We compared maximal tooth clenching-induced systemic autonomic responses, indicated by heart rate variability and blood pressure changes, in headache-free migraineurs (n=17) and control subjects (n=22)...
July 17, 2018: Journal of Oral Rehabilitation
Yoo-Na Kim, Kyung Jin Eoh, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Young Tae Kim
Objective: Intravenous leiomyomatosis (IVL) and benign metastasizing leiomyoma (BML) are uncommon variants of benign uterine leiomyomas with extrauterine manifestations. Categorizing the extent of disease allows clinicians to delineate the clinical spectrum and the level of sophistication for complete surgical resection. Methods: Twelve patients with IVL and BML were reviewed. They were divided into early versus late stage disease groups, and initial manifestation, clinical characteristics, laboratory values, surgical pathology, and follow up data were summarized...
July 2018: Obstetrics & Gynecology Science
Dan Liu, Daniel Oder, Tim Salinger, Kai Hu, Jonas Müntze, Frank Weidemann, Sebastian Herrmann, Georg Ertl, Christoph Wanner, Stefan Frantz, Stefan Störk, Peter Nordbeck
Objectives: Current guidelines highlight important therapy implications of cardiac fibrosis in patients with Fabry disease (FD). However, association between morphological and functional impairments with cardiac fibrosis in hereditary cardiomyopathies remains elusive. We investigated the association between echocardiography-determined cardiac dysfunction and cardiac MRI (cMRI)-detected myocardial fibrosis (late gadolinium enhancement, LE) in patients with FD with preserved left ventricular ejection fraction (≥50%)...
2018: Open Heart
Naresh Kumar Tripathy, Syed Husain Mustafa Rizvi, Saurabh Pratap Singh, Venkata Naga Srikanth Garikpati, Soniya Nityanand
We have evaluated the cardiomyogenic potential of clonal populations of human bone marrow mesenchymal stem cells (BM-MSC). Four rapidly proliferating clones of BM-MSC were obtained from the BM of a healthy donor which were then treated with 5-azacytidine and evaluated for the expression of GATA-4, NKx-2.5, FOG-2, TDGF-1, β-MHC, MEF2D and NPPA genes and cTnT, Desmin and β-MHC proteins. Of the four clones (i) Clone-1 had high expression of GATA-4 (1.89 fold (p<0.05), Nkx2.5 (2.29 fold; p<0.05), FOG2 (2...
2018: Journal of Stem Cells & Regenerative Medicine
Vittorio Racca, Paolo Castiglioni, Claudia Panzarino, Marina Saresella, Ivana Marventano, Alessandro Verde, Fabrizio Oliva, Maurizio Ferratini
Heart transplant (HTx) and left ventricular assist device (LVAD) implant are the best options for symptomatic end stage heart failure, but LVAD patients show lower rehabilitative outcome than HTx patients. To investigate the causes, we compared biomarkers levels and their association with rehabilitative outcome in 51 HTx and in 46 LVAD patients entering the same cardiac rehabilitation program. In both groups, routine biomarkers were measured at start (T1) and end (T2) of cardiac rehabilitation while homocysteine, leptine and IGF-1 were measured at T1 only...
July 17, 2018: Scientific Reports
F Hohendanner, I Romero, F Blaschke, F R Heinzel, B Pieske, L-H Boldt, A S Parwani
INTRODUCTION: The extent of left atrial (LA) adverse remodeling as a cardiac disease marker has become increasingly important. In patients with atrial fibrillation (AF), atrial remodeling (AR) is accompanied by increased mortality. The relation between LA function and the extent of low-voltage areas (LVAs) has not yet been systematically investigated. METHODS: In patients with AF undergoing catheter-ablation, LA was studied using echocardiography and ultra-high-density mapping (Rhythmia®)...
July 9, 2018: International Journal of Cardiology
K Feidantsis, K Mellidis, E Galatou, Z Sinakos, A Lazou
BACKGROUND AND AIM: The association of diabetes mellitus (DM) and poor metabolic control with high incidence of cardiovascular diseases is well established. The aim of this study was to investigate the potential cardioprotective effect of crocin (Crocus sativus L. extract) on diabetic heart dysfunction and to elucidate the mediating molecular mechanisms. METHODS AND RESULTS: Streptozotocin (STZ)-induced diabetic rats were treated with two different concentrations of crocin (10 or 20 mg/kg), while isolated cardiac myocytes exposed to 25 mM glucose, were treated with 1 or 10 μM of crocin...
July 13, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Viatcheslav Korshunov, Diego Penela, Markus Linhart, Juan Acosta, Mikel Martinez, David Soto-Iglesias, Juan Fernández-Armenta, Francesca Vassanelli, Mario Cabrera, Roger Borràs, Beatriz Jáuregui, Jose T Ortiz-Pérez, Rosario J Perea, Xavier Bosch, Damian Sanchez-Quintana, Lluis Mont, Antonio Berruezo
Aims: Left ventricular (LV) outflow tract ventricular arrhythmias (OTVA) are associated with hypertension (HT), older age, and LV dysfunction, suggesting that LV overload plays a role in the aetiopathogenesis. We hypothesized that anatomical modifications of the LV outflow tract (LVOT) could predict left vs. right OTVA site of origin (SOO). Methods and results: Fifty-six (32 men, 53 ± 18 years old) consecutive patients referred for OTVA ablation were included...
July 16, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Patrik Gilje, Martin Frydland, John Bro-Jeppesen, Josef Dankiewicz, Hans Friberg, Malin Rundgren, Yvan Devaux, Pascal Stammet, Mariam Al-Mashat, Jonas Jögi, Jesper Kjaergaard, Christian Hassager, David Erlinge
BACKGROUND: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. METHODS: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls...
July 17, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Na'ama Avitzur, Alessandro Satriano, Muhammad Afzal, Mariam Narous, Yoko Mikami, Reis Hansen, Gary Dobko, Jacqueline Flewitt, Carmen P Lydell, Andrew G Howarth, Kelvin Chow, Nowell M Fine, James A White
Cardiac amyloidosis (CA) is a significant contributor to heart failure with preserved ejection fraction and is appreciating expanding therapeutic options. Non-invasive tools aimed at accurate identification and surveillance of therapeutic response are of immediate and expanding need. While native and post-contrast T1 mapping quantify expansion of the extra-cellular compartment from amyloid protein deposition, 3D strain analysis of non-contrast cine images offers unique advantages relevant to high prevalence of renal insufficiency in this population and reduced dependency on field strength, pulse sequence, and vendor implementation...
July 16, 2018: International Journal of Cardiovascular Imaging
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