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Cardiac markers

T J W Dawes, A de Marvao, W Shi, D Rueckert, S A Cook, D P O'Regan
Right ventricular (RV) function has prognostic value in acute, chronic and peri-operative disease, although the complex RV contractile pattern makes rapid assessment difficult. Several two-dimensional (2D) regional measures estimate RV function, however the optimal measure is not known. High-resolution three-dimensional (3D) cardiac magnetic resonance cine imaging was acquired in 300 healthy volunteers and a computational model of RV motion created. Points where regional function was significantly associated with global function were identified and a 2D, optimised single-point marker (SPM-O) of global function developed...
November 14, 2018: Anaesthesia
Biao Zhang, Shuangshuang Li, Jinlong Men, Cheng Peng, Hua Shao, Zhihu Zhang
Crotonaldehyde is a ubiquitous hazardous pollutant, present in cigarette smoke and automobile exhaust and is endogenously generated by lipid peroxidation. Most of the current studies focus on its lung toxicity. However, there have been few investigations on the cardiac and renal toxicity caused by crotonaldehyde exposure. We hypothesized that oral intake of crotonaldehyde can cause inflammatory and oxidative/nitrosative damage to the heart and kidneys. Therefore, we treated male rats with crotonaldehyde by gavage at 0, 2...
November 14, 2018: Toxicology Mechanisms and Methods
Sho Takagi, Yuichiro Machida, Takashi Kobata, Daisuke Sakamoto, Shigeru Sakamoto, Tsugiyasu Kanda
OBJECTIVE: This study was performed to explore the association between circulating B-type natriuretic peptide (BNP) and other mortality-related factors in patients undergoing cardiovascular surgery. METHODS: In this observational study, multilevel linear regression analysis and multilevel survival analysis were performed to measure the log-transformed BNP (lnBNP) value at four time points in 197 patients with 788 repeated data measurements. Effects of the interaction between the time points and the two intervention groups (cardiac surgery and vascular surgery) were also investigated...
November 14, 2018: Journal of International Medical Research
Ali Navaei, Kiarash Rahmani Eliato, Robert Ros, Raymond Q Migrino, Brigham C Willis, Mehdi Nikkhah
Utilization of electrically conductive nanomaterials for developing nanocomposite scaffolds has been at the center of attention for engineering functional cardiac tissues. The primary motive in the use of conductive nanomaterials has been to develop biomimetic scaffolds to recapitulate the extracellular matrix (ECM) of the native heart and to promote cardiac tissue maturity, excitability and electrical signal propagation. Alternatively, it is well accepted that the inclusion of nanomaterials also alters the stiffness and nano-scale topography of the scaffolds...
November 14, 2018: Biomaterials Science
Kimmie Clark, Taylor Leathers, Duncan Rotich, Jianghua He, Katy Wirtz, Emmanuel Daon, Brigid C Flynn
Objective: Frailty has been associated with adverse outcomes following cardiac surgery. Gait speed has been validated as a marker of frailty. Slow gait speed has been found to be associated with mortality after cardiac surgery. However, it is unknown why slow gait speed predisposes to cardiac surgical mortality. Design: A retrospective analysis. Participants: Patients undergoing cardiac surgery who had a 5-meter walk test performed preoperatively (n=333 of 1735 total surgical patients) from January 2013 to March 2017...
2018: Critical Care Research and Practice
Takashi Hitsumoto
Background: The blood concentration of high-sensitivity cardiac troponin T (hs-cTnT) is a useful biomarker for myocardial injury or the pathogenesis of hypertension. Little is known about the relationship between hemorheology and myocardial injury in patients with hypertension. This cross-sectional study aimed to clarify the clinical impact of hemorheology on subclinical myocardial injury assessed with a microchannel array flow analyzer (MC-FAN) and its impact on hs-cTnT in patients with hypertension...
December 2018: Journal of Clinical Medicine Research
F F Liu, J N Gong, Y Jiang, T G Kuang, Y H Yang
Objective: To investigate the diagnostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and troponin Ⅰ (TnI) for detecting right ventricular dysfunction (RVD) in patients with non-high-risk acute pulmonary thromboembolism (APE). Methods: A retrospective analysis was performed in 96 adult patients [44 males, 52 females, aged (61±14) years] with non-high-risk APE from January 2015 to June 2016. All patients were divided into RVD group and non-RVD group according to whether there was right ventricular enlargement on echocardiography...
November 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
Wuqiang Zhu, Sean Reuter, Loren J Field
Background: Doxorubicin (DOX) is a widely used and effective anti-cancer therapeutic. DOX treatment is associated with both acute and late onset cardiotoxicity, limiting its overall efficacy. Here, the impact of cardiomyocyte cell cycle activation was examined in a juvenile model featuring aspects of acute and late onset DOX cardiotoxicity. Methods and Results: Two-week old MHC-cycD2 transgenic mice (which express cyclin D2 in postnatal cardiomyocytes and exhibit sustained cardiomyocyte cell cycle activity; D2 mice) and their wild type (WT) littermates received weekly DOX injections for 5 weeks (25 mg/kg cumulative dose)...
November 13, 2018: Cardiovascular Research
Chang-Lin Zhai, Guan-Min Tang, Gang Qian, Hui-Lin Hu, Shi-Jun Wang, Dong Yin, Song Zhang
Cardiovascular ischemic disease is a large class of diseases that are harmful to human health. The significant role of microRNAs (miRNAs) in terms of controlling cardiac injury has been reported in latest studies. MiR-98 is very important in regulating the apoptosis, the differentiation, the growth as well as the metastasis of cells. Nevertheless, the effect of miR-98 in the cardiac ischemia reperfusion (I/R) injury has rarely been investigated. In the current research, we found that the miR-98 expression was down-regulated in the cardiomyocytes subjected to hypoxia/reoxygenation (H/R) and in the myocardium of the I/R rats...
November 12, 2018: IUBMB Life
Espen Boe, Otto A Smiseth, Petter Storsten, Oyvind S Andersen, John Aalen, Morten Eriksen, Magnus R Krogh, Erik Kongsgaard, Espen W Remme, Helge Skulstad
Aims: There are conflicting data and no consensus on how to measure acute response to cardiac resynchronization therapy (CRT). This study investigates, which contractility indices are best markers of acute CRT response. Methods and results: In eight anaesthetized dogs with left bundle branch block, we measured left ventricular (LV) pressure by micromanometer and end-diastolic volume (EDV) and end-systolic volume (ESV) by sonomicrometry. Systolic function was measured as LV ejection fraction (EF), peak rate of LV pressure rise (LV dP/dtmax) and as a gold standard of contractility, LV end-systolic elastance (Ees), and volume axis intercept (V0) calculated from end-systolic pressure-volume relations (ESPVR)...
November 8, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Serdar Turkmen, Lutfu Askin, Kader Eliz Uzel, Huseyin Nacar, Veysi Kavalci, Erdal Akturk, Mustafa Yavuz Selçuk
BACKGROUND: Ankylosing spondylitis (AS) is a systemic inflammatory disease, and cardiac dysfunction has not been clearly described clinically. High-sensitivity cardiac troponin T (hs-cTnT) is a noninvasive marker for subclinical myocardial injury. OBJECTIVE: In this study, we aimed to investigate any relationship between hs-cTnT and left ventricular (LV) function evaluated via tissue Doppler imaging in AS patients with no known cardiac risk factor. METHODS: Our study used a cross-sectional case protocol design and was conducted between January 2016 and June 2016...
November 7, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Panagiota Sotiriou, Evangelia Kouidi, Asterios Karagiannis, Nikolaos Koutlianos, Parashos Geleris, Vasileios Vassilikos, Asterios Deligiannis
BACKGROUND: Structural and functional arterial adaptations with regard to the type and level of training in young athletes are understudied. Our research aimed at evaluating them in two types of exercise (dynamic and static) and two levels of engagement (high and recreational). METHODS: A total of 76 volunteers formed five groups. Group A included 17 high-level dynamic sports athletes 30·9 ± 6·4 years old, group B 14 recreational ones aged 28·7 ± 6·2 years, group C 15 high-level static sports athletes 26·4 ± 3·9 years old and group D 16 recreational ones, aged 25·8 ± 4·8 years...
November 11, 2018: Clinical Physiology and Functional Imaging
Timothy J Hatlen, Scott G Filler, Arnold Bayer, Sonia Shah, Shivani Shodhan, Tam T Van
Fungal endocarditis remains an uncommon clinical diagnosis, though is likely to become more frequent due to the global increase in transplantations and cardiac valvular surgery. A case of prosthetic valve endocarditis due to Aspergillus fumigatus is described that was diagnosed with serologic fungal markers and confirmed with positive blood cultures, an uncommon finding.
March 2019: Medical Mycology Case Reports
Nikhil Singh, Kegan James Moneghetti, Jeffrey Wilcox Christle, David Hadley, Daniel Plews, Victor Froelicher
The autonomic nervous system plays a major role in optimising function of the cardiovascular (CV) system, which in turn has important implications for CV health. Heart rate variability (HRV) is a measurable reflection of this balance between sympathetic and parasympathetic tone and has been used as a marker for cardiac status and predicting CV outcomes. Recently, the availability of commercially available heart rate (HR) monitoring systems has had important CV health implications and permits ambulatory CV monitoring on a scale not achievable with traditional cardiac diagnostics...
August 2018: Arrhythmia & Electrophysiology Review
Maria Consiglia Trotta, Rosa Maisto, Nicola Alessio, Anca Hermenean, Michele D'Amico, Clara Di Filippo
The study explored the anti-hypertrophic effect of the melanocortin MC5R stimulation in H9c2 cardiac myocytes exposed to high glucose. This has been done by using α-MSH and selective MC5R agonists and assessing the expression of GLUT4 and GLUT1 transporters, miR-133 and urotensin receptor levels as a marker of cardiac hypertrophy. The study shows for the first time an up-regulation of MC5R expression levels in H9c2 cardiomyocytes exposed to high glucose medium (33 mM D-glucose) for 48 h, compared to cells grown in normal glucose medium (5...
2018: Frontiers in Physiology
Zhen-Guo Ma, Yu-Pei Yuan, Hai-Ming Wu, Xin Zhang, Qi-Zhu Tang
Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic conditions. This review discusses specific markers and origin of cardiac fibroblasts (CFs), and the underlying mechanism involved in the development of cardiac fibrosis. Currently, there are no CFs-specific molecular markers. Most studies use co-labelling with panels of antibodies that can recognize CFs. Origin of fibroblasts is heterogeneous...
2018: International Journal of Biological Sciences
Ruiwen Li, Runfeng Zhang, Jiangying Yi, Wei Guo, Qiangjun Cheng, Lifeng Zhi, Yaqiu Lin
Schizothorax prenanti is a cold-water fish species with great economic importance in aquaculture in Western China, and the underlying mechanisms of muscle development and growth in S. prenanti remain to be elucidated. In this study, deep RNA sequencing was performed to provide an in-depth view of the transcriptome of skeletal muscle of S. prenanti with the specific objective to identify expressed genes in the skeletal muscle of S. prenanti at 30 days post-hatching (S01), 1 year (S02), and 3 years (S03)...
October 26, 2018: Gene
Cho-Kai Wu, Mao-Yuan M Su, Yi-Fan Wu, Juey-Jen Hwang, Lian-Yu Lin
Background: Heart failure with preserved ejection fraction (HFpEF) is characterized by heart failure symptoms and structural change (including fibrosis). The relationship between novel biomarkers and the above components remains unclear. Methods: Seventy-seven HFpEF patients were recruited. All patients underwent echocardiography with tissue doppler imaging, cardiac magnetic resonance imaging (CMRI), and measurement of plasma inflammatory, remodelling, endothelial function, and heart failure biomarker levels...
November 8, 2018: Journal of Clinical Medicine
Chen Chen, Lei-Xin Zou, Qiu-Yue Lin, Xiao Yan, Hai-Lian Bi, Xin Xie, Shuai Wang, Qing-Shan Wang, Yun-Long Zhang, Hui-Hua Li
Sustained cardiac hypertrophy is a major cause of heart failure (HF) and death. Recent studies have demonstrated that resveratrol (RES) exerts a protective role in hypertrophic diseases. However, the molecular mechanisms involved are not fully elucidated. In this study, cardiac hypertrophic remodeling in mice were established by pressure overload induced by transverse aortic constriction (TAC). Cardiac function was evaluated by echocardiography and invasive pressure-volume analysis. Cardiomyocyte size was detected by wheat germ agglutinin staining...
November 1, 2018: Redox Biology
Vinay Saunders, Jennifer M Dewing, Tilman Sanchez-Elsner, David I Wilson
BACKGROUND: The objective of this study was to investigate the expression and localisation of thymosin β4 (Tβ4) in the developing human heart. Tβ4 is a cardioprotective protein which may have therapeutic potential. While Tβ4 is an endogenously produced protein with known importance during development, its role within the developing human heart is not fully understood. Elucidating the localisation of Tβ4 within the developing heart will help in understanding its role during cardiac development and is crucial for understanding its potential for cardioprotection and repair in the adult heart...
2018: PloS One
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