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https://www.readbyqxmd.com/read/27883262/phytochemicals-enhance-antioxidant-enzyme-expression-to-protect-against-nsaid-induced-oxidative-damage-of-the-gastrointestinal-mucosa
#1
REVIEW
Yu-Ting Cheng, Chi-Cheng Lu, Gow-Chin Yen
The gastrointestinal mucosa provides the first protective barrier for digested food and xenobiotics, which are easily attacked by toxic substances. Non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, diclofenac, indomethacin, and ketoprofen, are widely used in clinical medicine, but these drugs may cause oxidative stress, leading to gastrointestinal damage, such as ulcers. Lansoprazol, omeprazole, and other clinical drugs are widely used to treat duodenal and gastric ulcers and haven been shown to have multiple biological functions, such as antioxidant activity and the ability to upregulate antioxidant enzymes in vivo...
November 24, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27872812/anti-inflammatory-effects-of-the-essential-oils-of-ginger-zingiber-officinale-roscoe-in-experimental-rheumatoid-arthritis
#2
Janet L Funk, Jennifer B Frye, Janice N Oyarzo, Jianling Chen, Huaping Zhang, Barbara N Timmermann
Ginger and its extracts have been used traditionally as anti-inflammatory remedies, with a particular focus on the medicinal properties of its phenolic secondary metabolites, the gingerols. Consistent with these uses, potent anti-arthritic effects of gingerol-containing extracts were previously demonstrated by our laboratory using an experimental model of rheumatoid arthritis, streptococcal cell wall (SCW)-induced arthritis. In this study, anti-inflammatory effects of ginger's other secondary metabolites, the essential oils (GEO), which contain terpenes with reported phytoestrogenic activity, were assessed in female Lewis rats with SCW-induced arthritis...
July 2016: PharmaNutrition
https://www.readbyqxmd.com/read/27821044/comparative-transcriptome-profiling-of-two-brassica-napus-cultivars-under-chromium-toxicity-and-its-alleviation-by-reduced-glutathione
#3
Rafaqat A Gill, Basharat Ali, Peng Cui, Enhui Shen, Muhammad A Farooq, Faisal Islam, Shafaqat Ali, Bizeng Mao, Weijun Zhou
BACKGROUND: Chromium (Cr) being multifarious industrial used element, is considered a potential environmental threat. Cr found to be a prospective water and soil pollutant, and thus it is a current area of concern. Oilseed rape (Brassica napus L.) is well known as a major source of edible oil around the globe. Due to its higher growth, larger biomass and capability to uptake toxic materials B. napus is considered a potential candidate plant against unfavorable conditions. To date, no study has been done that described the Cr and GSH mechanism at RNA-Seq level...
November 7, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27816008/in-silico-investigation-into-the-interactions-between-murine-5-ht3-receptor-and-the-principle-active-compounds-of-ginger-zingiber-officinale
#4
Anna E Lohning, Wolfgang Marx, Liz Isenring
Gingerols and shogaols are the primary non-volatile actives within ginger (Zingiber officinale). These compounds have demonstrated in vitro to exert 5-HT3 receptor antagonism which could benefit chemotherapy-induced nausea and vomiting (CINV). The site and mechanism of action by which these compounds interact with the 5-HT3 receptor is not fully understood although research indicates they may bind to a currently unidentified allosteric binding site. Using in silico techniques, such as molecular docking and GRID analysis, we have characterized the recently available murine 5-HT3 receptor by identifying sites of strong interaction with particular functional groups at both the orthogonal (serotonin) site and a proposed allosteric binding site situated at the interface between the transmembrane region and the extracellular domain...
October 26, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/27774555/electrochemical-detection-and-quantification-of-gingerol-species-in-ginger-zingiber-officinale-using-multiwalled-carbon-nanotube-modified-electrodes
#5
Korbua Chaisiwamongkhol, Kamonwad Ngamchuea, Christopher Batchelor-McAuley, Richard G Compton
We demonstrate the potential of electrochemical detection for the analysis of the 'strength' of ginger in ginger sample. This facile and fast detection method is aimed at the quality control in food industry. Specifically, we report adsorptive stripping voltammetry (AdsSV) as a technique for detection of gingerol compounds, the pungent components of ginger rhizome. Among the gingerols, 6-gingerol is the most abundant and is chosen as a model to characterise the behaviour of a wider range of related compounds...
October 24, 2016: Analyst
https://www.readbyqxmd.com/read/27771925/gingerol-and-its-role-in-chronic-diseases
#6
Yasmin Anum Mohd Yusof
Since antiquity, ginger or Zingiber officinale, has been used by humans for medicinal purposes and as spice condiments to enhance flavor in cooking. Ginger contains many phenolic compounds such as gingerol, shogaol and paradol that exhibit antioxidant, anti-tumor and anti-inflammatory properties. The role of ginger and its constituents in ameliorating diseases has been the focus of study in the past two decades by many researchers who provide strong scientific evidence of its health benefit. This review discusses research findings and works devoted to gingerols, the major pungent constituent of ginger, in modulating and targeting signaling pathways with subsequent changes that ameliorate, reverse or prevent chronic diseases in human studies and animal models...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27730672/daikenchuto-tu-100-suppresses-tumor-development-in-the-azoxymethane-and-apc-min-mouse-models-of-experimental-colon-cancer
#7
Takumu Hasebe, Jun Matsukawa, Daina Ringus, Jun Miyoshi, John Hart, Atsushi Kaneko, Masahiro Yamamoto, Toru Kono, Mikihiro Fujiya, Yutaka Kohgo, Chong-Zi Wang, Chun-Su Yuan, Marc Bissonnette, Mark W Musch, Eugene B Chang
Chemopreventative properties of traditional medicines and underlying mechanisms of action are incompletely investigated. This study demonstrates that dietary daikenchuto (TU-100), comprised of ginger, ginseng, and Japanese pepper effectively suppresses intestinal tumor development and progression in the azoxymethane (AOM) and APC(min/+) mouse models. For the AOM model, TU-100 was provided after the first of six biweekly AOM injections. Mice were sacrificed at 30 weeks. APC(min/+) mice were fed diet without or with TU-100 starting at 6 weeks, and sacrificed at 24 weeks...
October 12, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27709825/comparative-analysis-of-the-main-bioactive-components-of-xin-sheng-hua-granule-and-its-single-herbs-by-ultrahigh-performance-liquid-chromatography-with-tandem-mass-spectrometry
#8
Hanqing Pang, Jun Wang, Yuping Tang, Huiqin Xu, Liang Wu, Yi Jin, Zhenhua Zhu, Sheng Guo, Xuqin Shi, Shengliang Huang, Dazheng Sun, Jin-Ao Duan
Xin-Sheng-Hua granule, a representative formula for postpartum hemorrhage, has been used clinically to treat postpartum diseases. Its main bioactive components comprise aromatic acids, phthalides, alkaloids, flavonoids, and gingerols among others. To investigate the changes in main bioactive constituents in its seven single herbs before and after compatibility, a rapid, simple, and sensitive method was developed for comparative analysis of 27 main bioactive components by using ultrahigh-performance liquid chromatography with triple quadrupole electrospray tandem mass spectrometry for the first time...
November 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27700987/a-novel-method-for-the-quantitation-of-gingerol-glucuronides-in-human-plasma-or-urine-based-on-stable-isotope-dilution-assays
#9
Carola Schoenknecht, Gaby Andersen, Peter Schieberle
The bio-active compounds of ginger (Zingiber officinale Roscoe), the gingerols, are gaining considerable attention due to their numerous beneficial health effects. In order to elucidate the physiological relevance of the ascribed effects their bioavailability has to be determined taking their metabolization into account. To quantitate in vivo generated [6]-, [8]- and [10]-gingerol glucuronides in human plasma and urine after ginger tea consumption, a simultaneous and direct liquid chromatography-tandem mass spectrometry method based on stable isotope dilution assays was established and validated...
September 26, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27687000/changes-in-antioxidant-and-antibacterial-activities-as-well-as-phytochemical-constituents-associated-with-ginger-storage-and-polyphenol-oxidase-activity
#10
Ali Ghasemzadeh, Hawa Z E Jaafar, Asmah Rahmat
BACKGROUND: Herbal materials should be stored at optimal conditions in order to retain their nutritional quality. Proper storage has a significant impact on the quality of the herbs and spices. METHODS: The effects of storage temperature (5 and 15 °C) and time (4 and 8 months) on the phytochemical constituents associated with the antioxidant and antibacterial activities of ginger varieties (Halia bentong and Halia bara) were evaluated to determine the optimal storage conditions for ginger rhizomes...
September 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27685794/in-vitro-and-in-vivo-inhibition-of-aldose-reductase-and-advanced-glycation-end-products-by-phloretin-epigallocatechin-3-gallate-and-6-gingerol
#11
Chethan Sampath, Shengmin Sang, Mohamed Ahmedna
Hyperglycemic stress activates polyol pathway and aldose reductase (AR) key enzyme responsible for generating secondary complications during diabetes. In this study the therapeutic potential of phloretin, epigallocatechin 3-gallate (EGCG) and [6]-gingerol were evaluated for anti-glycating and AR inhibitory activity in vitro and in vivo systems. Human retinal pigment epithelial (HRPE) cells were induced with high glucose supplemented with the phloretin, EGCG and [6]-gingerol. Aldose reductase activity, total advanced glycation end products (AGEs) and enzyme inhibitor kinetics were assessed...
September 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27659301/anti-ageing-active-ingredients-from-herbs-and-nutraceuticals-used-in-traditional-chinese-medicine-pharmacological-mechanisms-and-implications-for-drug-discovery
#12
REVIEW
Chun-Yan Shen, Jian-Guo Jiang, Li Yang, Da-Wei Wang, Wei Zhu
Ageing, an unanswered question in the medical field, is a multifactorial process that results in a progressive functional decline in cells, tissues and organisms. Although it is impossible to prevent ageing, slowing down the rate of ageing is entirely possible to achieve. Traditional Chinese medicine (TCM) is characterized by the nourishing of life and its role in anti-ageing is getting more and more attention. This article summarizes the work done on the natural products from TCM that are reported to have anti-ageing effects, in the past two decades...
September 23, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27645308/revealing-the-effect-of-6-gingerol-6-shogaol-and-curcumin-on-mpges-1-gsk-3%C3%AE-and-%C3%AE-catenin-pathway-in-a549-cell-line
#13
Demirpolat Eren, Yerer Mukerrem Betul
BACKGROUND AND AIM: In our study, anticancer effects of 6-gingerol, 6-shogaol from ginger and curcumin from turmeric were investigated and the results were compared with each other. We aimed to reveal their effects on microsomal prostaglandine E2 synthase 1 (mPGES-1) which is related with cancer progression and inflammation as well as β-catenin and glycogen synthase kinase 3β (GSK-3β) that are the main components of Wnt/GSK3 pathway. As it is known activation of GSK-3β and high levels of mPGES-1 pathway leads to cell proliferation and aggravates cancer progression...
October 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27608741/structure-based-design-of-selective-phosphodiesterase-4b-inhibitors-based-on-ginger-phenolic-compounds
#14
Ming Xing, Gabriel Akyirem Akowuah, Vertika Gautam, Anand Gaurav
Phosphodiesterase 4 (PDE4) has been established as a drug target for inflammatory diseases of respiratory tract like asthma and chronic obstructive pulmonary disease. The selective inhibitors of PDE4B, a subtype of PDE4, are devoid of adverse effect like nausea and vomiting commonly associated with non-selective PDE4B inhibitors. This makes the development of PDE4B subtype selective inhibitors a desirable research goal. Thus, in the present study, molecular docking, molecular dynamic simulations and binding free energy were performed to explore potential selective PDE4B inhibitors based on ginger phenolic compounds...
September 9, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27606946/detailed-analysis-of-the-binding-mode-of-vanilloids-to-transient-receptor-potential-vanilloid-type-i-trpv1-by-a-mutational-and-computational-study
#15
Katsuya Ohbuchi, Yoshikazu Mori, Kazuo Ogawa, Eiji Warabi, Masahiro Yamamoto, Takatsugu Hirokawa
Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel and a multimodal sensor protein. Since the precise structure of TRPV1 was obtained by electron cryo-microscopy, the binding mode of representative agonists such as capsaicin and resiniferatoxin (RTX) has been extensively characterized; however, detailed information on the binding mode of other vanilloids remains lacking. In this study, mutational analysis of human TRPV1 was performed, and four agonists (capsaicin, RTX, [6]-shogaol and [6]-gingerol) were used to identify amino acid residues involved in ligand binding and/or modulation of proton sensitivity...
2016: PloS One
https://www.readbyqxmd.com/read/27596388/enhanced-extraction-of-oleoresin-from-ginger-zingiber-officinale-rhizome-powder-using-enzyme-assisted-three-phase-partitioning
#16
Sadineni Varakumar, Kannamangalam Vijayan Umesh, Rekha S Singhal
Ginger (Zingiber officinale R.) is a popular spice used worldwide. The oleoresin consists of gingerols, shogaols and other non-volatiles as chief bioactive constituents. Three phase partitioning (TPP), a bioseparation technique, based on partitioning of polar constituents, proteins, and hydrophobic constituents in three phases comprising of water, ammonium sulphate and t-butanol, was explored for extraction of oleoresin and gingerols from dry powder. Parameters optimized for maximum recovery of gingerols and [6]-shogaol were ammonium sulphate concentration, ratio of t-butanol to slurry, solid loading and pH...
February 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27589022/uhplc-esi-ms-ms-for-the-quantification-of-eight-major-gingerols-and-shogaols-in-ginger-products-effects-of-ionization-polarity-and-mobile-phase-modifier-on-the-sensitivity
#17
Su Yeon Park, Mun Yhung Jung
We developed and validated an improved ultra high performance liquid chromatography (UHPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) method for the fast separation and quantification of 8 major gingerols and shogaols (4-, 6-, 8-, 10-, and 12-gingerols, and 6-, 8-, and 10-shogaols) in gingerol products. The ionization polarity and mobile phase modifier greatly affected the mass ion profiles and sensitivity of the analytes. A mobile phase modifier of 0.05 mM ammonium formate dramatically decreased the sodium adduct ions and greatly increased the protonated ions of the gingerols and shogaols...
October 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27569883/in%C3%A2-vitro-anti-hydatic-and-immunomodulatory-effects-of-ginger-and-6-gingerol
#18
Manel Amri, Chafia Touil-Boukoffa
OBJECTIVE: To study in vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol as an alternative therapy for cystic echinococcosis. METHODS: Effect of a commonly used herbal product and ginger (Zingiber officinale) towards protoscoleces (PSC) and cyst wall in vitro was studied. The effect of [6]-gingerol, and the pungent constituent of ginger, was also evaluated on PSC culture. Furthermore, the activity of both extracts in association with interferon-gamma (IFN-γ) on PSC co-cultured with mononuclear cells of hydatic patients was evaluated...
August 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27563640/design-formulation-and-evaluation-of-ginger-medicated-chewing-gum
#19
Abolfazl Aslani, Alireza Ghannadi, Farnaz Rostami
BACKGROUND: Various ginger compounds improve gastrointestinal problems and motion sickness. The main effects of ginger allocate to some phenolics such as gingerols and shogaols that act as their active agents. Chewing gums are among convenient dosage forms which patients prefer due to their advantages. Hence, this study tried to design, formulate, and evaluate ginger chewing gum of favorable taste and texture to avoid motion sickness and have gastro-protective and anti-oxidant effect...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/27546232/6-gingerol-rich-fraction-from-zingiber-officinale-ameliorates-carbendazim-induced-endocrine-disruption-and-toxicity-in-testes-and-epididymis-of-rats
#20
M Salihu, B O Ajayi, I A Adedara, D de Souza, J B T Rocha, E O Farombi
This study evaluated the protective effects of 6-gingerol-rich fraction (6-GRF) from Zingiber officinale on carbendazim (CBZ)-induced reproductive toxicity in rats. Adult male rats were treated with either CBZ (50 mg/kg) alone or in combination with 6-GRF (50, 100 and 200 mg/kg) for 14 consecutive days. Gas chromatography-mass spectrometry (GCMS) analysis revealed that 6-GRF consists of ten bioactive chemical components with 6-gingerol being the most abundant (30.76%). Administration of 6-GRF significantly (p < ...
August 22, 2016: Andrologia
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