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https://www.readbyqxmd.com/read/29303546/establishment-of-lcms-based-platform-for-discovery-of-quorum-sensing-inhibitors-signal-detection-in-pseudomonas-aeruginosa-pao1
#1
Manoj Kushwaha, Shreyans K Jain, Nisha Sharma, Vidushi Abrol, Sundeep Jaglan, Ram A Vishwakarma
Targeting the main three networking systems viz. Las, RhI and PQS via natural quenchers is a new ray of hope for combating the persistent behavior of Pseudomonas aeruginosa. In the bacterial chemical vocabulary pyocyanin, N-AHLs and rhamnolipids are the main keywords, which are responsible for the social and nomadic behavior of P. aeruginosa. In the present work LCMS-based real-time qualitative and quantitative analysis of pyocyanin, green phenazine, N-AHLs, and rhamnolipids were performed. The quantitative analysis indicates that the production of pyocyanin and NHSLs increases with time while the production of rhamnolipids discontinued after 16 Hrs...
January 5, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29207520/plants-of-the-genus-zingiber-as-a-source-of-bioactive-phytochemicals-from-tradition-to-pharmacy
#2
REVIEW
Mehdi Sharifi-Rad, Elena Maria Varoni, Bahare Salehi, Javad Sharifi-Rad, Karl R Matthews, Seyed Abdulmajid Ayatollahi, Farzad Kobarfard, Salam A Ibrahim, Dima Mnayer, Zainul Amiruddin Zakaria, Majid Sharifi-Rad, Zubaida Yousaf, Marcello Iriti, Adriana Basile, Daniela Rigano
Plants of the genus Zingiber (Family Zingiberaceae) are widely used throughout the world as food and medicinal plants. They represent very popular herbal remedies in various traditional healing systems; in particular, rhizome of Zingiber spp. plants has a long history of ethnobotanical uses because of a plethora of curative properties. Antimicrobial activity of rhizome essential oil has been extensively confirmed in vitro and attributed to its chemical components, mainly consisting of monoterpene and sesquiterpene hydrocarbons such as α-zingiberene, ar-curcumene, β-bisabolene and β-sesquiphellandrene...
December 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29199237/active-ingredients-of-hange-shashin-to-baicalelin-and-6-gingerol-inhibit-5-fluorouracil-induced-upregulation-of-cxcl1-in-the-colon-to-attenuate-diarrhea-development
#3
Hiroyasu Sakai, Shoko Tabata, Minami Kimura, Saori Yabe, Yosuke Isa, Yuki Kai, Fumiaki Sato, Tetsuro Yumoto, Kanako Miyano, Minoru Narita, Yasuhito Uezono
5-Fluorouracil (5-FU) is widely used as an anti cancer drug and is known to cause severe diarrhea. Recently we suggested that levels of chemokine (C-X-C motif) ligand 1 (CXCL1) and neutrophil recruitment in the colonic mucosa were drastically increased by the 5-FU administration in mice. Hange-shashin-to (HST) is prescribed in Japan for treat gastritis, stomatitis, and inflammatory diarrhea. We therefore examined the effects of HST and its active ingredients on 5-FU-induced CXCL1 upregulation in cultured colon tissue, and also examined the effects of HST on 5-FU-induced diarrhea development in the mouse...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29168275/6-shogaol-induces-apoptosis-and-enhances-radiosensitivity-in-head-and-neck-squamous-cell-carcinoma-cell-lines
#4
Ulana Kotowski, Lorenz Kadletz, Sven Schneider, Elisabeth Foki, Rainer Schmid, Rudolf Seemann, Dietmar Thurnher, Gregor Heiduschka
Ginger (Zingiber officinale Roscoe) is used for a wide array of conditions in traditional medicine in Asia, but little is known about the effect on head and neck cancer. In this study, the effect of two major pharmacologically active compounds of ginger, 6-gingerol and 6-shogaol, were studied on head and neck cancer cell lines. Furthermore, experiments in combination with established treatment methods for head and neck cancer were performed. Proliferation assays showed a dose-dependent reduction of cell viability...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29146336/effect-directed-analysis-of-ginger-zingiber-officinale-and-its-food-products-and-quantification-of-bioactive-compounds-via-high-performance-thin-layer-chromatography-and-mass-spectrometry
#5
S Krüger, A Bergin, G E Morlock
Decision makers responsible for quality management along the food chain need to reflect on their analytical tools that should ensure quality of food and especially superfood. The "4ables" in target analysis (stable, extractable, separable, detectable) focusing on marker compounds do not cover all relevant information about the sample. On the example of ginger, a streamlined quantitative bioprofiling was developed for effect-directed analysis of 17 commercially available ginger and ginger-containing products via high-performance thin-layer chromatography (HPTLC-UV/Vis/FLD-bioassay)...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29135250/structure-activity-relationships-of-6-and-8-gingerol-analogs-as-anti-biofilm-agents
#6
Hyunsuk Choi, So-Young Ham, Eunji Cha, Yujin Shin, Han-Shin Kim, Jeong Kyu Bang, Sang-Hyun Son, Hee-Deung Park, Youngjoo Byun
Pseudomonas aeruginosa is a causative agent of chronic infections in immunocompromised patients. Disruption of quorum sensing circuits is an attractive strategy for treating diseases associated with P. aeruginosa infection. In this study, we designed and synthesized a series of gingerol analogs targeting LasR, a master regulator of quorum sensing networks in P. aeruginosa. Structure-activity relationship studies showed that a hydrogen-bonding interaction in the head section, stereochemistry and rotational rigidity in the middle section, and optimal alkyl chain length in the tail section are important factors for the enhancement of LasR-binding affinity and for the inhibition of biofilm formation...
November 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29126908/a-novel-formulation-of-6-gingerol-proliposomes-with-enhanced-oral-bioavailability-and-antitumor-effect
#7
Qilong Wang, Qiuyu Wei, Qiuxuan Yang, Xia Cao, Qiang Li, Feng Shi, Shan Shan Tong, Chunlai Feng, Qingtong Yu, Jiangnan Yu, Ximing Xu
[6]-Gingerol, one of the components of the rhizome of Ginger, has a variety of biological activities such as anticoagulant, antioxidative, antitumor, anti-inflammatory, antihypertensive, and so forth. However, as one of the homologous phenolic ketones, [6]-gingerol is insoluble in water which limits its applications. Herein, we prepared [6]-gingerol proliposomes through modified thin-film dispersion method, which was spherical or oval, and physicochemically stable with narrow size distribution. Surprisingly, in vitro release of [6]-gingerol loaded proliposome compared with the free [6]-gingerol was significantly higher and its oral bioavailability increased 5-fold in vivo...
November 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29113064/inhibition-of-cyclic-adenosine-monophosphate-specific-phosphodiesterase-by-various-food-plant-derived-phytotherapeutic-agents
#8
Teresa Röhrig, Olga Pacjuk, Silvia Hernández-Huguet, Johanna Körner, Katharina Scherer, Elke Richling
Background: Phosphodiesterases (PDEs) play a major role in the regulation of cyclic adenosine monophosphate (cAMP)- and cyclic guanosine monophosphate (cGMP)-mediated pathways. Their inhibitors exhibit anti-inflammatory, vasodilatory and antithrombotic effects. Therefore, consumption of foods with PDE-inhibiting potential may possess beneficial influence on the risk of cardiovascular diseases. Methods: Four plant extracts (Arbutus unedo, Camellia sinensis, Cynara scolymus, Zingiber officinale) with promising ingredient profiles and physiological effects were tested for their ability to inhibit cAMP-specific PDE in vitro in a radioactive assay...
November 4, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29101807/6-shogaol-ameliorates-diabetic-nephropathy-through-anti-inflammatory-hyperlipidemic-anti-oxidative-activity-in-db-db-mice
#9
Yun Xu, Liwei Bai, Xuehui Chen, Yan Li, Yan Qin, Xiangyu Meng, Qinggui Zhang
The prevalence of type 2 diabetes mellitus has been increasing worldwide and more than two thirds of the patients may develop diabetic nephropathy (DN). However, the efficiency of existing approaches on DN progression is limited. 6-Shogaol (6-SG), a major dehydrated derivative of gingerols, possesses various biological properties. The present study was designed to evaluate the possible effects of 6-SG on DN in db/db mice and to investigate the mechanisms. We revealed that 6-SG reduced the levels of fasting blood glucose, serum insulin, C-peptide, glycosylated hemoglobin A1c, and systolic blood pressure...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29069785/-10-gingerol-induces-apoptosis-and-inhibits-metastatic-dissemination-of-triple-negative-breast-cancer-in-vivo
#10
Ana Carolina B M Martin, Angelina M Fuzer, Amanda B Becceneri, James Almada da Silva, Rebeka Tomasin, Delphine Denoyer, Soo-Hyun Kim, Katherine A McIntyre, Helen B Pearson, Belinda Yeo, Aadya Nagpal, Xiawei Ling, Heloisa S Selistre-de-Araújo, Paulo Cézar Vieira, Marcia R Cominetti, Normand Pouliot
There is increasing interest in the use of non-toxic natural products for the treatment of various pathologies, including cancer. In particular, biologically active constituents of the ginger oleoresin (Zingiber officinale Roscoe) have been shown to mediate anti-tumour activity and to contribute to the anti-inflammatory, antioxidant, antimicrobial, and antiemetic properties of ginger. Here we report on the inhibitory properties of [10]-gingerol against metastatic triple negative breast cancer (TNBC) in vitro and in vivo...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29058093/transcriptome-analysis-reveals-the-genetic-basis-underlying-the-biosynthesis-of-volatile-oil-gingerols-and-diarylheptanoids-in-ginger-zingiber-officinale-rosc
#11
Yusong Jiang, Qinhong Liao, Yong Zou, Yiqing Liu, Jianbin Lan
BACKGROUND: Ginger (Zingiber officinale Rosc.) is a popular flavoring that widely used in Asian, and the volatile oil in ginger rhizomes adds a special fragrance and taste to foods. The bioactive compounds in ginger, such as gingerols, diarylheptanoids, and flavonoids, are of significant value to human health because of their anticancer, anti-oxidant, and anti-inflammatory properties. However, as a non-model plant, knowledge about the genome sequences of ginger is extremely limited, and this limits molecular studies on this plant...
October 23, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28988496/6-gingerol-prevents-mehp-induced-dna-damage-in-human-umbilical-vein-endothelia-cells
#12
G Yang, X Gao, L Jiang, X Sun, X Liu, M Chen, X Yao, Q Sun, S Wang
Mono (2-ethylhexyl) phthalate (MEHP) is the principal metabolite of di (2-etylhexyl) phthalate, which is widely used as a plasticizer, especially in medical devices. MEHP has toxic effects on cardiovascular system. The aim of this study was to investigate the possibility that 6-gingerol may inhibit the oxidative DNA damage of MEHP in human umbilical vein endothelial cells (HUVECs) and the potential mechanism. The comet assay was used to monitor DNA strand breaks. We have shown that 6-gingerol significantly reduced the DNA strand breaks caused by MEHP...
November 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28941901/antimicrobial-efficacy-of-phytochemicals-against-bacillus-cereus-in-reconstituted-infant-rice-cereal
#13
Hayriye Cetin-Karaca, Melissa C Newman
The objective of this study was to determine the potential use of Trans-cinnamaldehyde (TC), (-)-Epigallocatechin gallate (EGCG) and [10]-Gingerol (GI) to inhibit the growth of B. cereus in infant rice cereal reconstituted with infant formula. Samples were inoculated with either vegetative cells or spores of B. cereus (ATCC 14579), and they were treated with 500 ppm (mg/L) TC, EGCG and GI. They were stored at 7 °C, 23 °C, or 37 °C for 0, 4, 8 and 24 h to simulate advance preparation, handling and temperature abuse...
February 2018: Food Microbiology
https://www.readbyqxmd.com/read/28904557/ginger-ingredients-alleviate-diabetic-prostatic-complications-effect-on-oxidative-stress-and-fibrosis
#14
Basma G Eid, Hala Mosli, Atif Hasan, Hany M El-Bassossy
Prostatic complications are common in patients with diabetes. This study investigated the effect of different ginger ingredients: zingerone, geraniol, and 6-gingerol on the prostate in diabetic rats. Diabetes was induced in Wistar rats by streptozotocin intraperitoneal injection (50 mg/kg), and the rats were left for 10 weeks to develop prostatic complications. In diabetic treated groups, rats received daily oral zingerone, geraniol, and 6-gingerol in doses of 20, 200, and 75 mg/kg, respectively, in the last 8 weeks...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28873530/antioxidant-activities-of-ginger-extract-and-its-constituents-toward-lipids
#15
Wenhui Si, Yan Ping Chen, Jianhao Zhang, Zhen-Yu Chen, Hau Yin Chung
Lipid oxidation-a major cause of food product deterioration-necessitates the use of food additives to inhibit food oxidation. Ginger extract (GE) has been reported to possess antioxidant properties. However, components isolated from ginger have been rarely reported to inhibit fat oxidation. Herein, antioxidant properties of GE and four pure components derived from it (6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol) were examined and their properties were compared to those of butylated hydroxytoluene. GE and the constituent components exhibited antioxidant properties that might be attributed to their hydroxyl groups and suitable solubilizing side chains...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28872603/ginger-phytochemicals-inhibit-cell-growth-and-modulate-drug-resistance-factors-in-docetaxel-resistant-prostate-cancer-cell
#16
Chi-Ming Liu, Chiu-Li Kao, Yu-Ting Tseng, Yi-Ching Lo, Chung-Yi Chen
Ginger has many bioactive compounds with pharmacological activities. However, few studies are known about these bioactive compounds activity in chemoresistant cells. The aim of the present study was to investigate the anticancer properties of ginger phytochemicals in docetaxel-resistant human prostate cancer cells in vitro. In this study, we isolated 6-gingerol, 10-gingerol, 4-shogaol, 6-shogaol, 10-shogaol, and 6-dehydrogingerdione from ginger. Further, the antiproliferation activity of these compounds was examined in docetaxel-resistant (PC3R) and sensitive (PC3) human prostate cancer cell lines...
September 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28869564/phenolics-isolated-from-aframomum-meleguta-enhance-proliferation-and-ossification-markers-in-bone-cells
#17
Ashraf B Abdel-Naim, Abdullah A Alghamdi, Mardi M Algandaby, Fahad A Al-Abbasi, Ahmed M Al-Abd, Hossam M Abdallah, Ali M El-Halawany, Masao Hattori
Osteoporosis is a serious health problem characterized by decreased bone mineral density and deterioration of bone microarchitecture. Current antiosteoporotic agents exhibit a wide range of adverse effects; meanwhile, phytochemicals are effective and safer alternatives. In the current work, nine compounds belonging to hydroxyphenylalkane and diarylheptanoid groups were isolated from Aframomum meleguea seeds and identified as 6-gingerol (1), 6-paradol (2), 8-dehydrogingerdione (3), 8-gingerol (4), dihydro-6-paradol (5), dihydrogingerenone A (6), dihydrogingerenone C (7), 1,7-bis(3,4-dihydroxy-5-methoxyphenyl)heptane-3,5-diyl diacetate (8), and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(3,4-dihydroxyphenyl)heptane-3,5-diyl diacetate (9)...
September 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28846029/ayurvedic-preparation-of-zingiber-officinale-roscoe-effects-on-cardiac-and-on-smooth-muscle-parameters
#18
Alberto Leoni, Roberta Budriesi, Ferruccio Poli, Mariacaterina Lianza, Alessandra Graziadio, Alice Venturini, Massimiliano Broccoli, Matteo Micucci
The rhizome of the Zingiber officinale Roscoe, a biennial herb growing in South Asia, is commonly known as ginger. Ginger is used in clinical disorders, such as constipation, dyspepsia, diarrhoea, nausea and vomiting and its use is also recommended by the traditional medicine for cardiopathy, high blood pressure, palpitations and as a vasodilator to improve the circulation. The decoction of ginger rhizome is widely used in Ayurvedic medicine. In this papery by high-performance liquid chromatography, we have seen that its main phytomarkers were 6-gingerol, 8-gingerol and 6-shogaol and we report the effects of the decoction of ginger rhizome on cardiovascular parameters and on vascular and intestinal smooth muscle...
August 28, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28842272/pharmacotherapeutic-potential-of-ginger-and-its-compounds-in-age-related-neurological-disorders
#19
REVIEW
Jin Gyu Choi, Sun Yeou Kim, Minsun Jeong, Myung Sook Oh
Age-related neurological disorders (ANDs), including neurodegenerative diseases, are multifactorial disorders with a risk that increases with aging. ANDs are generally characterized by common neuropathological conditions of the central nervous system, such as oxidative stress, neuroinflammation, and protein misfolding. Recently, efforts have been made to overcome ANDs because of the increase in age-dependent prevalence. Ginger, the rhizome of Zingiber officinale Roscoe, is a popular food spice and has a long history of use in traditional medicine for treating various disease symptoms...
August 24, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28836409/cardio-protective-role-of-gingerol-along-with-prominent-anti-diabetic-cardiomyopathy-action-in-a-streptozotocin-induced-diabetes-mellitus-rat-model
#20
Li-Ya Yu, Wen-Lei Shi, Xin-GuiGuo Guo
OBJECTIVES: Diabetic cardiomyopathy (DCM) is characterized as a coronary heart disease which expands during diabetes due to alterations in the myocardial function and structure. The currentstudy intends to elucidate the protective effect of gingerol on DCM in a streptozotocin (STZ)-induced diabetes mellitus (DM) rat model. MATERIALS AND METHODS: In this experimental study, the animals were divided into three groups: normal control, DM control, and DM+gingerol (10 mg/kg)...
October 2017: Cell Journal
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