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Gingerol

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https://www.readbyqxmd.com/read/28106738/6-paradol-and-6-shogaol-the-pungent-compounds-of-ginger-promote-glucose-utilization-in-adipocytes-and-myotubes-and-6-paradol-reduces-blood-glucose-in-high-fat-diet-fed-mice
#1
Chien-Kei Wei, Yi-Hong Tsai, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh, Fang-Rong Chang
The anti-diabetic activity of ginger powder (Zingiber officinale) has been recently promoted, with the recommendation to be included as one of the dietary supplements for diabetic patients. However, previous studies presented different results, which may be caused by degradation and metabolic changes of ginger components, gingerols, shogaols and paradols. Therefore, we prepared 10 ginger active components, namely 6-, 8-, 10-paradols, 6-, 8-, 10-shogaols, 6-, 8-, 10-gingerols and zingerone, and evaluated their anti-hyperglycemic activity...
January 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28102023/6-gingerol-rich-fraction-prevents-disruption-of-histomorphometry-and-marker-enzymes-of-testicular-function-in-carbendazim-treated-rats
#2
M Salihu, B O Ajayi, I A Adedara, E O Farombi
Previous investigations demonstrated that 6-gingerol-rich fraction (6-GRF) prevented testicular toxicity via inhibition of oxidative stress and endocrine disruption in CBZ-treated rats. The influence of 6-GRF on alterations in histomorphometry and marker enzymes of testicular function in CBZ-treated rats which hitherto has not been reported was investigated in this study. The animals were orally administered either CBZ (50 mg/kg) alone or in combination with 6-GRF (50, 100 and 200 mg/kg) for 14 consecutive days...
January 19, 2017: Andrologia
https://www.readbyqxmd.com/read/28093231/the-effects-of-6-gingerol-on-reproductive-improvement-liver-functioning-and-cyclooxygenase-2-gene-expression-in-estradiol-valerate-induced-polycystic-ovary-syndrome-in-wistar-rats
#3
Parisa Sadat Pournaderi, Parichehreh Yaghmaei, Hamidreza Khodaei, Zahra Noormohammadi, Seyed Hossein Hejazi
6- gingerol is the major pungent ingredient of ginger with anti-inflammatory and antioxidant properties. In this study, we evaluate the effects of 6- gingerol on the biochemical parameters and ovarian histological improvements in estradiol valerate (EV) induced PCOS rats. Thirty six female Wistar rats were divided into 4 groups: control, received normal diet, PCOS control, received 4 mg/kg EV injection for 28 days and two experimental groups, received an EV injection for 28 days and followed by 6- gingerol (200 μg/kg and 400 μg/kg) for 14 days...
January 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28067282/gastroprotective-6-gingerol-aspirinate-as-a-novel-chemopreventive-prodrug-of-aspirin-for-colon-cancer
#4
Yingdong Zhu, Fang Wang, Yantao Zhao, Pei Wang, Shengmin Sang
A growing body of research suggests daily low-dose aspirin (ASA) reduces heart diseases and colorectal cancers. However, the major limitation to the use of aspirin is its side effect to cause ulceration and bleeding in the gastrointestinal tract. Preclinical studies have shown that ginger constituents ameliorate ASA-induced gastric ulceration. We here report the design and synthesis of a novel prodrug of aspirin, [6]-gingerol aspirinate (GAS). Our data show that GAS exerts enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065501/synthesis-docking-cytotoxicity-and-lta4h-inhibitory-activity-of-new-gingerol-derivatives-as-potential-colorectal-cancer-therapy
#5
Mai H El-Naggar, Amira Mira, Fatma M Abdel Bar, Kuniyoshi Shimizu, Mohamed M Amer, Farid A Badria
Leukotriene A4 hydrolase (LTA4H) is a proinflammatory enzyme that generates the inflammatory mediator leukotriene which may play an important role in chronic inflammation associated carcinogenesis. [6]-gingerol, the major bioactive compound of Zingiber officinale, is a potential inhibitor of LTA4H, a highly expressed enzyme in colorectal carcinoma. Eighteen compounds; seven of natural origin (including [4]-, [6]-, [8]-, and [10]-gingerol), five new and six known semi-synthesized [6]-gingerol derivatives were examined using docking, in vitro cytotoxicity against human colon cancer cells (HCT-116) and LTA4H aminopeptidase and epoxide hydrolase inhibitory studies...
December 29, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28051355/pharmacokinetic-interaction-of-aconitine-liquiritin-and-6-gingerol-in-a-traditional-chinese-herbal-formula-sini-decoction
#6
Sen Sun, Qingshan Chen, Jiyun Ge, Xiang Liu, Xinxia Wang, Qi Zhan, Hai Zhang, Guoqing Zhang
This study aimed to investigate the pharmacokinetic interaction of the three ingredients in a traditional Chinese herbal formulation, Sini Decoction, and provide evidence for its compatibility mechanism. Firstly, the effect of liquiritin and 6-gingerol on the pharmacokinetic parameters of aconitine were investigated in rats by using a sensitive and reliable LC-MS/MS method. Then the Caco-2 cell monolayer model and Rhodamine-123 uptake assay were used to investigate the effect of liquiritin and 6-gingerol on the absorption of aconitine and the activity of P-gp...
January 4, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28043879/-6-gingerol-and-6-shogaol-active-ingredients-of-the-traditional-japanese-medicine-hangeshashinto-relief-oral-ulcerative-mucositis-induced-pain-via-action-on-na-channels
#7
Suzuro Hitomi, Kentaro Ono, Kiyoshi Terawaki, Chinami Matsumoto, Keita Mizuno, Kiichiro Yamaguchi, Ryota Imai, Yuji Omiya, Tomohisa Hattori, Yoshio Kase, Kiyotoshi Inenaga
The traditional Japanese herbal medicine hangeshashinto (HST) has beneficial effects for the treatment of oral ulcerative mucositis (OUM) in cancer patients. However, the ingredient-based mechanism that underlies its pain-relieving activity remains unknown. In the present study, to clarify the analgesic mechanism of HST on OUM-induced pain, we investigated putative HST ingredients showing antagonistic effects on Na(+) channels in vitro and in vivo. A screen of 21 major ingredients using automated patch-clamp recordings in channel-expressing cells showed that [6]-gingerol and [6]-shogaol, two components of a Processed Ginger extract, considerably inhibited voltage-activated Na(+) currents...
December 30, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27925249/inhibition-of-glucuronidation-and-oxidative-metabolism-of-buprenorphine-using-gras-compounds-or-dietary-constituents-supplements-in-vitro-proof-of-concept
#8
Neha V Maharao, Anand A Joshi, Phillip M Gerk
The present study investigated the potential of generally recognized as safe compounds or dietary substances to inhibit the presystemic metabolism of buprenorphine and increase its oral bioavailability. Using IVIVE, the buprenorphine extraction ratios in intestine and liver were predicted as 96% and 71%, respectively. In addition, the relative fraction of buprenorphine metabolized by oxidation and glucuronidation in these two organs was estimated using pooled human intestinal and liver microsomes. In both organs, oxidation appeared to be the major metabolic pathway with a six and four fold higher intrinsic clearance than glucuronidation in intestine and liver, respectively...
December 7, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/27883262/phytochemicals-enhance-antioxidant-enzyme-expression-to-protect-against-nsaid-induced-oxidative-damage-of-the-gastrointestinal-mucosa
#9
REVIEW
Yu-Ting Cheng, Chi-Cheng Lu, Gow-Chin Yen
The gastrointestinal mucosa provides the first protective barrier for digested food and xenobiotics, which are easily attacked by toxic substances. Non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, diclofenac, indomethacin, and ketoprofen, are widely used in clinical medicine, but these drugs may cause oxidative stress, leading to gastrointestinal damage, such as ulcers. Lansoprazol, omeprazole, and other clinical drugs are widely used to treat duodenal and gastric ulcers and haven been shown to have multiple biological functions, such as antioxidant activity and the ability to upregulate antioxidant enzymes in vivo...
November 24, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27872812/anti-inflammatory-effects-of-the-essential-oils-of-ginger-zingiber-officinale-roscoe-in-experimental-rheumatoid-arthritis
#10
Janet L Funk, Jennifer B Frye, Janice N Oyarzo, Jianling Chen, Huaping Zhang, Barbara N Timmermann
Ginger and its extracts have been used traditionally as anti-inflammatory remedies, with a particular focus on the medicinal properties of its phenolic secondary metabolites, the gingerols. Consistent with these uses, potent anti-arthritic effects of gingerol-containing extracts were previously demonstrated by our laboratory using an experimental model of rheumatoid arthritis, streptococcal cell wall (SCW)-induced arthritis. In this study, anti-inflammatory effects of ginger's other secondary metabolites, the essential oils (GEO), which contain terpenes with reported phytoestrogenic activity, were assessed in female Lewis rats with SCW-induced arthritis...
July 2016: PharmaNutrition
https://www.readbyqxmd.com/read/27821044/comparative-transcriptome-profiling-of-two-brassica-napus-cultivars-under-chromium-toxicity-and-its-alleviation-by-reduced-glutathione
#11
Rafaqat A Gill, Basharat Ali, Peng Cui, Enhui Shen, Muhammad A Farooq, Faisal Islam, Shafaqat Ali, Bizeng Mao, Weijun Zhou
BACKGROUND: Chromium (Cr) being multifarious industrial used element, is considered a potential environmental threat. Cr found to be a prospective water and soil pollutant, and thus it is a current area of concern. Oilseed rape (Brassica napus L.) is well known as a major source of edible oil around the globe. Due to its higher growth, larger biomass and capability to uptake toxic materials B. napus is considered a potential candidate plant against unfavorable conditions. To date, no study has been done that described the Cr and GSH mechanism at RNA-Seq level...
November 7, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27816008/in-silico-investigation-into-the-interactions-between-murine-5-ht3-receptor-and-the-principle-active-compounds-of-ginger-zingiber-officinale
#12
Anna E Lohning, Wolfgang Marx, Liz Isenring
Gingerols and shogaols are the primary non-volatile actives within ginger (Zingiber officinale). These compounds have demonstrated in vitro to exert 5-HT3 receptor antagonism which could benefit chemotherapy-induced nausea and vomiting (CINV). The site and mechanism of action by which these compounds interact with the 5-HT3 receptor is not fully understood although research indicates they may bind to a currently unidentified allosteric binding site. Using in silico techniques, such as molecular docking and GRID analysis, we have characterized the recently available murine 5-HT3 receptor by identifying sites of strong interaction with particular functional groups at both the orthogonal (serotonin) site and a proposed allosteric binding site situated at the interface between the transmembrane region and the extracellular domain...
November 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/27774555/electrochemical-detection-and-quantification-of-gingerol-species-in-ginger-zingiber-officinale-using-multiwalled-carbon-nanotube-modified-electrodes
#13
Korbua Chaisiwamongkhol, Kamonwad Ngamchuea, Christopher Batchelor-McAuley, Richard G Compton
We demonstrate the potential of electrochemical detection for the analysis of the 'strength' of ginger in ginger sample. This facile and fast detection method is aimed at the quality control in food industry. Specifically, we report adsorptive stripping voltammetry (AdsSV) as a technique for detection of gingerol compounds, the pungent components of ginger rhizome. Among the gingerols, 6-gingerol is the most abundant and is chosen as a model to characterise the behaviour of a wider range of related compounds...
October 24, 2016: Analyst
https://www.readbyqxmd.com/read/27771925/gingerol-and-its-role-in-chronic-diseases
#14
Yasmin Anum Mohd Yusof
Since antiquity, ginger or Zingiber officinale, has been used by humans for medicinal purposes and as spice condiments to enhance flavor in cooking. Ginger contains many phenolic compounds such as gingerol, shogaol and paradol that exhibit antioxidant, anti-tumor and anti-inflammatory properties. The role of ginger and its constituents in ameliorating diseases has been the focus of study in the past two decades by many researchers who provide strong scientific evidence of its health benefit. This review discusses research findings and works devoted to gingerols, the major pungent constituent of ginger, in modulating and targeting signaling pathways with subsequent changes that ameliorate, reverse or prevent chronic diseases in human studies and animal models...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27730672/daikenchuto-tu-100-suppresses-tumor-development-in-the-azoxymethane-and-apc-min-mouse-models-of-experimental-colon-cancer
#15
Takumu Hasebe, Jun Matsukawa, Daina Ringus, Jun Miyoshi, John Hart, Atsushi Kaneko, Masahiro Yamamoto, Toru Kono, Mikihiro Fujiya, Yutaka Kohgo, Chong-Zi Wang, Chun-Su Yuan, Marc Bissonnette, Mark W Musch, Eugene B Chang
Chemopreventative properties of traditional medicines and underlying mechanisms of action are incompletely investigated. This study demonstrates that dietary daikenchuto (TU-100), comprised of ginger, ginseng, and Japanese pepper effectively suppresses intestinal tumor development and progression in the azoxymethane (AOM) and APC(min/+) mouse models. For the AOM model, TU-100 was provided after the first of six biweekly AOM injections. Mice were sacrificed at 30 weeks. APC(min/+) mice were fed diet without or with TU-100 starting at 6 weeks, and sacrificed at 24 weeks...
October 12, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27709825/comparative-analysis-of-the-main-bioactive-components-of-xin-sheng-hua-granule-and-its-single-herbs-by-ultrahigh-performance-liquid-chromatography-with-tandem-mass-spectrometry
#16
Hanqing Pang, Jun Wang, Yuping Tang, Huiqin Xu, Liang Wu, Yi Jin, Zhenhua Zhu, Sheng Guo, Xuqin Shi, Shengliang Huang, Dazheng Sun, Jin-Ao Duan
Xin-Sheng-Hua granule, a representative formula for postpartum hemorrhage, has been used clinically to treat postpartum diseases. Its main bioactive components comprise aromatic acids, phthalides, alkaloids, flavonoids, and gingerols among others. To investigate the changes in main bioactive constituents in its seven single herbs before and after compatibility, a rapid, simple, and sensitive method was developed for comparative analysis of 27 main bioactive components by using ultrahigh-performance liquid chromatography with triple quadrupole electrospray tandem mass spectrometry for the first time...
November 2016: Journal of Separation Science
https://www.readbyqxmd.com/read/27700987/a-novel-method-for-the-quantitation-of-gingerol-glucuronides-in-human-plasma-or-urine-based-on-stable-isotope-dilution-assays
#17
Carola Schoenknecht, Gaby Andersen, Peter Schieberle
The bio-active compounds of ginger (Zingiber officinale Roscoe), the gingerols, are gaining considerable attention due to their numerous beneficial health effects. In order to elucidate the physiological relevance of the ascribed effects their bioavailability has to be determined taking their metabolization into account. To quantitate in vivo generated [6]-, [8]- and [10]-gingerol glucuronides in human plasma and urine after ginger tea consumption, a simultaneous and direct liquid chromatography-tandem mass spectrometry method based on stable isotope dilution assays was established and validated...
November 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27687000/changes-in-antioxidant-and-antibacterial-activities-as-well-as-phytochemical-constituents-associated-with-ginger-storage-and-polyphenol-oxidase-activity
#18
Ali Ghasemzadeh, Hawa Z E Jaafar, Asmah Rahmat
BACKGROUND: Herbal materials should be stored at optimal conditions in order to retain their nutritional quality. Proper storage has a significant impact on the quality of the herbs and spices. METHODS: The effects of storage temperature (5 and 15 °C) and time (4 and 8 months) on the phytochemical constituents associated with the antioxidant and antibacterial activities of ginger varieties (Halia bentong and Halia bara) were evaluated to determine the optimal storage conditions for ginger rhizomes...
September 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27685794/in-vitro-and-in-vivo-inhibition-of-aldose-reductase-and-advanced-glycation-end-products-by-phloretin-epigallocatechin-3-gallate-and-6-gingerol
#19
Chethan Sampath, Shengmin Sang, Mohamed Ahmedna
Hyperglycemic stress activates polyol pathway and aldose reductase (AR) key enzyme responsible for generating secondary complications during diabetes. In this study the therapeutic potential of phloretin, epigallocatechin 3-gallate (EGCG) and [6]-gingerol were evaluated for anti-glycating and AR inhibitory activity in vitro and in vivo systems. Human retinal pigment epithelial (HRPE) cells were induced with high glucose supplemented with the phloretin, EGCG and [6]-gingerol. Aldose reductase activity, total advanced glycation end products (AGEs) and enzyme inhibitor kinetics were assessed...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27659301/anti-ageing-active-ingredients-from-herbs-and-nutraceuticals-used-in-traditional-chinese-medicine-pharmacological-mechanisms-and-implications-for-drug-discovery
#20
REVIEW
Chun-Yan Shen, Jian-Guo Jiang, Li Yang, Da-Wei Wang, Wei Zhu
Ageing, an unanswered question in the medical field, is a multifactorial process that results in a progressive functional decline in cells, tissues and organisms. Although it is impossible to prevent ageing, slowing down the rate of ageing is entirely possible to achieve. Traditional Chinese medicine (TCM) is characterized by the nourishing of life and its role in anti-ageing is getting more and more attention. This article summarizes the work done on the natural products from TCM that are reported to have anti-ageing effects, in the past two decades...
September 23, 2016: British Journal of Pharmacology
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