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https://www.readbyqxmd.com/read/29049814/cost-effectiveness-of-testing-and-treatment-for-latent-tuberculosis-infection-in-residents-born-outside-the-united-states-with-and-without-medical-comorbidities-in-a-simulation-model
#1
Abriana Tasillo, Joshua A Salomon, Thomas A Trikalinos, C Robert Horsburgh, Suzanne M Marks, Benjamin P Linas
Importance: Testing for and treating latent tuberculosis infection (LTBI) is among the main strategies to achieve TB elimination in the United States. The best approach to testing among non-US born residents, particularly those with comorbid conditions, is uncertain. Objective: To estimate health outcomes, costs, and cost-effectiveness of LTBI testing and treatment among non-US born residents with and without medical comorbidities. Design, Setting, and Participants: Decision analytic tree and Markov cohort simulation model among non-US born residents with no comorbidities, with diabetes, with HIV infection, or with end-stage renal disease (ESRD) using a health care sector perspective with 3% annual discounting...
October 16, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29049787/sutureless-aortic-valve-replacement-versus-transcatheter-aortic-valve-implantation-a-meta-analysis-of-comparative-matched-studies-using-propensity-score-matching
#2
Massimo Meco, Antonio Miceli, Andrea Montisci, Francesco Donatelli, Silvia Cirri, Matteo Ferrarini, Antonio Lio, Mattia Glauber
OBJECTIVES: The aim of this meta-analysis was to compare outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) with those undergoing surgical aortic valve replacement using sutureless valves. METHODS: A systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was performed. RESULTS: No randomized controlled trials were identified...
September 11, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049356/treatment-satisfaction-with-injectable-disease-modifying-therapies-in-patients-with-relapsing-remitting-multiple-sclerosis-the-stick-study
#3
Oscar Fernández, Eduardo Duran, Teresa Ayuso, Luis Hernández, Inmaculada Bonaventura, Mireia Forner
BACKGROUND: Treatment satisfaction in patients with relapsing-remitting multiple sclerosis (RRMS) may impact adherence and thus clinical outcomes. The objective of this study was to measure the satisfaction of patients with RRMS with injectable disease-modifying therapies (DMTs) and to evaluate the factors associated with treatment satisfaction. MATERIAL AND METHODS: In this observational retrospective study conducted in the neurology departments of 35 hospitals throughout Spain, demographic data, disease characteristics, and information on treatment with injectable DMTs were collected at a single scheduled visit...
2017: PloS One
https://www.readbyqxmd.com/read/29049268/patient-and-parent-satisfaction-with-sling-use-after-pediatric-upper-extremity-fractures-a-randomized-controlled-trial-of-a-customized-cast-sling-versus-standard-cast-and-sling
#4
Aristides I Cruz, Steven F DeFroda, Joseph A Gil, Heather Hansen, Alexandre Bolous, Michaela Procaccini, Mark R Zonfrillo
BACKGROUND: Long arm cast immobilization after operative and nonoperative treatment of pediatric upper extremity fractures is common. The use of a sling to aid in carrying the casted extremity as well as provide further immobilization is also common practice. Off-the-shelf slings vary in quality and fit, can be confusing for parents/patients to apply, and lead to frustration and dissatisfaction with its use. The purpose of this investigation was to compare patient/parent centered outcomes after the use of a customized sling compared with a standard sling by utilizing a prospective, randomized-controlled trial...
October 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29049267/variation-among-pediatric-orthopaedic-surgeons-when-treating-medial-epicondyle-fractures
#5
Meghan Hughes, Karan Dua, Nathan N O'Hara, Brian K Brighton, Theodore J Ganley, William L Hennrikus, Martin J Herman, Joshua E Hyman, J Todd Lawrence, Charles T Mehlman, Kenneth J Noonan, Norman Y Otsuka, Richard M Schwend, M Wade Shrader, Brian G Smith, Paul D Sponseller, Joshua M Abzug
BACKGROUND: Medial epicondyle fractures are a common pediatric and adolescent injury accounting for 11% to 20% of elbow fractures in this population. This purpose of this study was to determine the variability among pediatric orthopaedic surgeons when treating pediatric medial epicondyle fractures. METHODS: A discrete choice experiment was conducted to determine which patient and injury attributes influence the management of medial epicondyle fractures by pediatric orthopaedic surgeons...
October 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29049231/dose-duration-and-strain-of-bacillus-calmette-guerin-in-the-treatment-of-nonmuscle-invasive-bladder-cancer-meta-analysis-of-randomized-clinical-trials
#6
Yongjun Quan, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Hyung Suk Kim, Ja Hyeon Ku
BACKGROUND: Intravesical bacillus Calmette-Guerin (BCG) instillation is widely used as an adjuvant therapy after transurethral resection of bladder tumor (TURBT) in patients with intermediate- and high-risk nonmuscle invasive bladder cancer (NMIBC). However, the effective dose, duration, and strain of BCG have not yet been clearly determined. We aimed to elucidate the relationship between dose, duration, and strain of BCG and clinical outcomes in NMIBC patients treated with TURBT. METHODS: We conducted a literature search in Embase, Scopus, and PubMed databases for all relevant articles published up to October 2016 in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049172/primary-cardiac-angiosarcoma-a-case-report
#7
Ruiping Zhang, Lu Li, Xinming Li, Yanlin Chu, Jihua Wu, Yunge Gao
BACKGROUND: Primary cardiac angiosarcoma is rare, but it is the most aggressive type of cardiac malignant tumor. When disease is confirmed it is often late in its stage resulting in a poor prognosis. CASE PRESENTATION: We reported a 52-year-old woman who complained of dyspnea for 2 months and dry cough for 10 days. Computed tomography (CT), F-fluorodeoxyglucose (F-FDG), positron emission tomography-computed tomography (PET-CT), and transthoracic echocardiography showed a space-occupying lesion 7 cm × 5 cm × 5 cm in the right atrium...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049095/a-clinical-evaluation-of-the-impact-of-the-bayesian-penalized-likelihood-reconstruction-algorithm-on-pet-fdg-metrics
#8
Delphine Vallot, Olivier Caselles, Leonor Chaltiel, Anthony Fernandez, Erwan Gabiache, Lawrence Dierickx, Slimane Zerdoud, Mathilde Bauriaud, Frédéric Courbon
PURPOSE: The aim of this study was to evaluate the impact of using the Bayesian penalized likelihood (BPL) algorithm on a bismuth germanium oxide positron emission tomography (PET)/computed tomography (CT) system for F-FDG PET/CT exams in case of low injected activity and scan duration. MATERIALS AND METHODS: F-FDG respiratory gated PET/CT performed on 102 cancer patients, injected with ∼2 MBq/kg of F-FDG, were reconstructed using two algorithms: ordered subset expectation maximization (OSEM) and BPL...
October 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29049049/treatable-traits-of-chronic-airways-disease
#9
James Fingleton, Jo Hardy, Richard Beasley
PURPOSE OF REVIEW: To describe the rationale on which the treatable traits approach to the management of airways disease is based and the issues that need to be considered for its implementation in clinical practice. RECENT FINDINGS: In clinical practice, treatable traits can be classified according to both endotypes and phenotypes, broadly grouped within pulmonary, extrapulmonary, environmental and behavioural factors. Specific investigations and treatments are undertaken for each of the traits rather than a 'one size fits all' stepwise approach to pharmacological treatment which currently represents the core of asthma and chronic obstructive pulmonary disease (COPD) guidelines...
October 18, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29049000/oral-nutrition-as-a-form-of-pre-operative-enhancement-in-patients-undergoing-surgery-for-colorectal-cancer-a-systematic-review
#10
Emma R J Bruns, Tanja E Argillander, Baukje Van Den Heuvel, Christianne J Buskens, Peter Van Duijvendijk, Renate M Winkels, Annette Kalf, Edwin S Van Der Zaag, Eelco B Wassenaar, Willem A Bemelman, Barbara C Van Munster
BACKGROUND: Nutritional status has major impacts on the outcome of surgery, in particular in patients with cancer. The aim of this review was to assess the merit of oral pre-operative nutritional support as a part of prehabilitation in patients undergoing surgery for colorectal cancer. METHODS: A systematic literature search and meta-analysis was performed according to the Preferred Reporting of Systematic Reviews and Meta-Analyses (PRISMA) recommendations in order to review all trials investigating the effect of oral pre-operative nutritional support in patients undergoing colorectal surgery...
October 19, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29048751/severity-strata-for-five-patient-reported-outcomes-in-adults-with-atopic-dermatitis
#11
P P Vakharia, R Chopra, R Sacotte, N Patel, S Immaneni, T White, R Kantor, D Y Hsu, E L Simpson, J I Silverberg
BACKGROUND: Multiple patient-reported outcomes have been used to assess the burden of atopic dermatitis (AD). Some are disease specific, e.g. the Patient Oriented Eczema Measure (POEM). While others pertain to itch, e.g. Numerical Rating Scale (NRS)-itch, ItchyQoL and 5-D itch, or dermatologic disease in general, e.g. Dermatology Life Quality Index (DLQI). Development of severity strata is essential for proper interpretability of these assessments. We sought to confirm previously developed strata for POEM, DLQI and raw ItchyQoL, and develop strata for the NRS-itch, mean ItchyQOL and 5-D itch scale for use in adults with AD...
October 19, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29048474/transinnominate-approach-for-transcatheter-aortic-valve-replacement-single-centre-experience-of-minimally-invasive-alternative-access
#12
Luigi Pirelli, Jacob S Scheinerman, Derek R Brinster, Nirav C Patel, Alaeldin Eltom, Jonathan M Hemli, Chad A Kliger
OBJECTIVES: Iliofemoral arteries have been the preferred access for transcatheter aortic valve replacement (TAVR). When these arteries are too small, calcified or tortuous, an alternative access must be considered. Transinnominate (TI) access is an extrathoracic approach that does not require manipulation of major neurovascular structures or the apex. The aim of this study is to evaluate the efficacy and safety of TI TAVR as an alternative access in patients with severe aortic stenosis not amenable to a transfemoral approach...
October 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29047342/effectiveness-and-patient-safety-of-platelet-aggregation-inhibitors-in-the-prevention-of-cardiovascular-disease-and-ischemic-stroke-in-older-adults-a-systematic-review
#13
REVIEW
Maren Meinshausen, Anja Rieckert, Anna Renom-Guiteras, Moritz Kröger, Christina Sommerauer, Ilkka Kunnamo, Yolanda V Martinez, Aneez Esmail, Andreas Sönnichsen
BACKGROUND: Platelet aggregation inhibitors (PAI) are among the most frequently prescribed drugs in older people, though evidence about risks and benefits of their use in older adults is scarce. The objectives of this systematic review are firstly to identify the risks and benefits of their use in the prevention and treatment of vascular events in older adults, and secondly to develop recommendations on discontinuing PAI in this population if risks outweigh benefits. METHODS: Staged systematic review consisting of three searches...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29045679/prostate-cancer-patient-characteristics-associated-with-a-strong-preference-to-preserve-sexual-function-and-receipt-of-active-surveillance
#14
James R Broughman, Ramsankar Basak, Matthew E Nielsen, Bryce B Reeve, Deborah S Usinger, Kiayni C Spearman, Paul A Godley, Ronald C Chen
Background: Men with early-stage prostate cancer have multiple options that have similar oncologic efficacy but vary in terms of their impact on quality of life. In low-risk cancer, active surveillance is the option that best preserves patients' sexual function, but it is unknown if patient preference affects treatment selection. Our objectives were to identify patient characteristics associated with a strong preference to preserve sexual function and to determine whether patient preference and baseline sexual function level are associated with receipt of active surveillance in low-risk cancer...
October 16, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29045502/long-term-toxicity-of-cisplatin-in-germ-cell-tumor-survivors
#15
M Chovanec, M Abu Zaid, N Hanna, N El-Kouri, L H Einhorn, C Albany
Context: Testicular germ cell tumors (GCT) are highly curable. A multidisciplinary approach, including cisplatin-based chemotherapy has resulted in cure in the majority of patients with GCT. Thus, the life expectancy of survivors will extend to many decades post diagnosis. Late treatment toxicities associated with cisplatin-based chemotherapy may impact their future health. Objective: To systematically evaluate evidence regarding the long-term toxicity of cisplatin in GCT survivors...
July 14, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045345/leadless-cardiac-pacemakers-present-and-the-future
#16
Derek S Chew, Vikas Kuriachan
PURPOSE OF REVIEW: Pacing technology for many decades has been composed of a generator attached to leads that are usually transvenous. Recently, leadless pacemakers have been studied in clinical settings and now available for use in many countries. This includes the single-component Nanostim Leadless Cardiac Pacemaker and Micra Transcatheter Pacing System, as well as the multicomponent Wireless Stimulation Endocardial system. RECENT FINDINGS: Clinical studies in single-component leadless pacing technology has shown that they can be successfully implanted with minimal complications...
October 17, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29045338/a-clinical-evaluation-of-the-impact-of-the-bayesian-penalized-likelihood-reconstruction-algorithm-on-pet-fdg-metrics
#17
Delphine Vallot, Olivier Caselles, Leonor Chaltiel, Anthony Fernandez, Erwan Gabiache, Lawrence Dierickx, Slimane Zerdoud, Mathilde Bauriaud, Frédéric Courbon
PURPOSE: The aim of this study was to evaluate the impact of using the Bayesian penalized likelihood (BPL) algorithm on a bismuth germanium oxide positron emission tomography (PET)/computed tomography (CT) system for F-FDG PET/CT exams in case of low injected activity and scan duration. MATERIALS AND METHODS: F-FDG respiratory gated PET/CT performed on 102 cancer patients, injected with ∼2 MBq/kg of F-FDG, were reconstructed using two algorithms: ordered subset expectation maximization (OSEM) and BPL...
November 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29045308/thirty-days-only-double-antiplatelet-therapy-after-drug-eluting-stenting-could-a-short-term-treatment-be-advantageous
#18
Gianni Casella, Elvira Resciniti, Pamela Gallo
: The duration of dual antiplatelet therapy (DAPT) after coronary stenting has been evaluated in randomized studies with apparently conflicting results. Prolonged DAPT reduces late stent thrombosis and myocardial infarction, but at the expenses of more hemorrhages. On the contrary, bleedings are associated with higher morbidity and mortality. Thus, in patients at high risk of bleeding, the less effective bare-metal stents could be preferred to drug-eluting stents (DES) due to the shortened DAPT needed. However, new DES technology carries a lower risk of stent thrombosis and casts doubts on the recommended prolonged DAPT regimen after DES...
October 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29045286/ability-of-non-strain-diastolic-parameters-to-predict-doxorubicin-induced-cardiomyopathy-a-systematic-review-with-meta-analysis
#19
Mohamed Nagiub, J V Ian Nixon, Michael C Kontos
Doxorubicin is an important cause of chemotherapy-induced cardiomyopathy. Prior studies have found conflicting results of whether non-strain diastolic parameters can predict doxorubicin- induced cardiotoxicity. We performed a systematic review of English written publications using preferred reporting items for systematic reviews and meta-analysis guidelines (PRISMA). The following inclusion criteria were applied: cancer subjects, echo-derived non-strain diastolic profile, patients compared before and after treatment to predict systolic dysfunction...
October 17, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/29045250/clinical-decision-making-for-immunotherapy-in-metastatic-renal-cell-carcinoma
#20
Manuela Schmidinger
PURPOSE OF REVIEW: To review the treatment options in metastatic renal cell carcinoma (mRCC) in the light of new immunotherapy results. RECENT FINDINGS: Second-line treatment strategies for treatment of mRCC after progression on first-line VEGF-targeted therapy have recently undergone a major change. Treatment guidelines currently recommend the use of either nivolumab, a programmed cell death 1 (PD-1) inhibitor, or cabozantinib, an inhibitor of multiple receptor tyrosine kinases, as preferred choices...
October 17, 2017: Current Opinion in Urology
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