keyword
MENU ▼
Read by QxMD icon Read
search

NMSC

keyword
https://www.readbyqxmd.com/read/27922162/nonmelanoma-skin-cancer-in-mountain-guides-high-prevalence-and-lack-of-awareness-warrant-development-of-evidence-based-prevention-tools
#1
Alexander Zink, Elisabeth Koch, Florian Seifert, Markus Rotter, Christoph D Spinner, Tilo Biedermann
AIMS OF THE STUDY: Nonmelanoma skin cancer (NMSC) is the most common cancer in Switzerland and Europe. The main causative factor is exposure to ultraviolet radiation, which puts outdoor workers in general at a higher risk of developing NMSC than indoor workers. However, few studies have clinically examined the risk of developing NMSC to outdoor workers, especially mountain guides. We aimed to investigate the prevalence of NMSC and corresponding precancerous lesions, and the associated risk behaviour of mountain and ski guides in order to develop future prevention programmes...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27898109/body-mass-index-and-risk-of-non-melanoma-skin-cancer-cumulative-evidence-from-prospective-studies
#2
Daijun Zhou, Jun Wu, Gaoxing Luo
Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A dose-response meta-analysis was conducted to quantitatively summarize the evidence. PubMed and Embase databases were searched for relevant studies. Study-specific relative risk (RR) and 95% confidence interval (CI) for an increase in BMI of 5 kg/m(2) was computed with the generalized least squares trend estimation, and these risk estimates were combined with the random-effects model...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27892658/occupational-syncarcinogenesis-in-the-skin-combined-effects-of-two-carcinogens-from-the-german-occupational-disease-list
#3
Heinrich Dickel, Otto Blome, Beate Dickel, Thomas Bruckner, Eggert Stockfleth, Silas Paras Soemantri
BACKGROUND: Though scientifically undisputed, cutaneous syncarcinogenesis is not reflected in German occupational disease (OD) regulations, which tend to be guided by the tenet of monocausality. Recognition of nonmelanoma skin cancer (NMSC) and its precursor lesions as OD requires individual assessment as to whether the requirements pursuant to either OD 5103 (occupational exposure to natural UV radiation) or OD 5102 (occupational exposure to polycyclic aromatic hydrocarbons) are fulfilled...
November 28, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27890175/malignancy-and-janus-kinase-inhibition
#4
REVIEW
Padmapriya Sivaraman, Stanley B Cohen
The use of biologics such as anti-tumor necrosis factor and oral Janus kinase inhibitors have revolutionized the treatment of rheumatoid arthritis (RA). The risk of malignancies such as lymphomas, lung cancer, and nonmelanoma skin cancers (NMSCs) is greater in patients with RA compared with the general population. The incidence of all malignancy (excluding NMSC) was similar in tofacitinib users compared with the general population. The rates of overall and site-specific malignancies in patients with RA treated with tofacitinib are similar to what is expected in the RA population and not different from disease-modifying antirheumatic drugs and biologics...
February 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27889616/developments-in-l2-based-human-papillomavirus-hpv-vaccines
#5
REVIEW
Christina Schellenbacher, Richard B S Roden, Reinhard Kirnbauer
Infections with sexually transmitted high-risk Human Papillomavirus (hrHPV), of which there are at least 15 genotypes, are responsible for a tremendous disease burden by causing cervical, and subsets of other ano-genital and oro-pharyngeal carcinomas, together representing 5% of all cancer cases worldwide. HPV subunit vaccines consisting of virus-like particles (VLP) self-assembled from major capsid protein L1 plus adjuvant have been licensed. Prophylactic vaccinations with the 2-valent (HPV16/18), 4-valent (HPV6/11/16/18), or 9-valent (HPV6/11/16/18/31/33/45/52/58) vaccine induce high-titer neutralizing antibodies restricted to the vaccine types that cause up to 90% of cervical carcinomas, a subset of other ano-genital and oro-pharyngeal cancers and 90% of benign ano-genital warts (condylomata)...
November 23, 2016: Virus Research
https://www.readbyqxmd.com/read/27878887/why-do-young-adults-tan
#6
Charlotte L Thomas, Pablo Fernández Peñas
Australia has the highest incidence of non-melanoma skin cancer (NMSC)(1) . NMSC evolution is strongly linked to ultraviolet (UV) radiation exposure (2) and is largely preventable through its reduction. Prominent Australian public health campaigns since the 1980s (3) aimed to educate the public about the dangers of excessive sun exposure and the need for sun-protection, assuming that increased knowledge will be translated into behavioural change. However, positive attitudes towards tanned skin have been shown to correlate with UV exposure(4,5) ...
November 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27876303/rapid-visualization-of-nonmelanoma-skin-cancer
#7
Ethan Walker, Margaret Mann, Kord Honda, Allison Vidimos, Mark D Schluchter, Brian Straight, Matthew Bogyo, Daniel Popkin, James P Basilion
BACKGROUND: Mohs micrographic surgery examines all margins of the resected sample and has a 99% cure rate. However, many nonmelanoma skin cancers (NMSCs) are not readily amenable to Mohs micrographic surgery. This defines an unmet clinical need to assess the completeness of non-Mohs micrographic surgery resections during surgery to prevent re-excision/recurrence. OBJECTIVE: We sought to examine the utility of quenched activity-based probe imaging to discriminate cancerous versus normal-appearing skin tissue...
November 19, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27870055/cancer-risks-after-solid-organ-transplantation-and-after-long-term-dialysis
#8
Maria Hortlund, Laila Sara Arroyo Mühr, Hans Storm, Gerda Engholm, Joakim Dillner, Davit Bzhalava
Immunosuppression involves an inability to control virus infections and increased incidence of virus-associated cancers. Some cancers without known viral etiology are also increased, but data on exactly which cancer forms are increased has been inconsistent. To provide a reliable and generalizable estimate, with high statistical power and long follow-up time, we assessed cancer risks using comprehensive, population-based registries in 2 different countries and from 2 different immunosuppressed patient groups (solid organ transplant recipients (OTRs) and long-term dialysis patients (LDPs))...
November 21, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27868187/basic-aspects-of-the-pathogenesis-and-prevention-of-non-melanoma-skin-cancer-in-solid-organ-transplant-recipients-a-review
#9
REVIEW
Héctor C Perez, Xiomara Benavides, Juan S Perez, Maria A Pabon, Jaime Tschen, Silvia J Maradei-Anaya, Luis Lopez, Eyner Lozano
INTRODUCTION: As numbers of transplant recipients and survival rates increase, the vulnerability of this population to several malignancies also rises. Non-melanoma skin cancer (NMSC) carries the highest rates of morbidity and mortality in this population. To avoid these malignancies, it is necessary to identify particular risk factors in transplant recipients and to follow preventive protocols. METHODS: The MEDLINE and EMBASE databases were reviewed using as keywords the medical subject headings (MeSH) "transplantation", "skin neoplasm" and "prevention"...
November 21, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27865382/bcg-infection-in-mice-is-promoted-by-na%C3%A3-ve-mesenchymal-stromal-cells-msc-and-suppressed-by-poly-a-u-conditioned-msc
#10
Yakov Sh Schwartz, Sergey N Belogorodtsev, Pavel N Filimonov, Andrey G Cherednichenko, Sergey V Pustylnikov, Vladimir A Krasnov
Mesenchymal stromal cells (MSC) transplantation is an actively studied therapeutic approach used in regenerative medicine and in the field of control of immunoinflammatory response. Conditioning of MSC in culture can form their predominantly pro- or anti-inflammatory phenotypes. We demonstrated that poly(A:U)-conditioning of bone marrow-derived mouse MSC induced predominantly pro-inflammatory phenotype. The effects of administration of naïve MSC (nMSC) or conditioned MSC (cMSC) on the course of mycobacterial infection were studied...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27862360/nonmelanoma-skin-cancer-mortality-rising-in-susceptible-australians
#11
D Czarnecki
Non-melanoma skin cancer (NMSC) is a major health problem in Australia and the incidence is steadily increasing ((1).) However, the age standardized mortality rate (ASMR) for the entire population has not increased since 1996 ((2)) . One possible reason for this discrepancy is that the Australian population has greatly changed in the last 30 years with many people at low risk for skin cancer have migrated to Australia ((3).) Unless an adjustment is made for the population change, the data will show that the ASMR is stabilizing...
November 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27859308/resatorvid-based-pharmacological-antagonism-of-cutaneous-tlr4-blocks-uv-induced-nf-%C3%AE%C2%BAb-and-ap-1-signaling-in-keratinocytes-and-mouse-skin
#12
Jaroslav Janda, Nichole Burkett, Karen Blohm-Mangone, Vivian Huang, Clara Curiel-Lewandrowski, David S Alberts, Emanuel F Petricoin, Valerie S Calvert, Janine Einspahr, Zigang Dong, Ann M Bode, Georg T Wondrak, Sally E Dickinson
Cutaneous exposure to solar ultraviolet (UV) radiation is a major causative factor in skin carcinogenesis, and improved molecular strategies for efficacious chemoprevention of non-melanoma skin cancer (NMSC) are urgently needed. Toll-like receptor 4 (TLR4) signaling has been shown to drive skin inflammation, photoimmunosuppression and chemical carcinogenesis. Here we have examined the feasibility of genetic and pharmacological antagonism targeting cutaneous TLR4 for the suppression of UV-induced NF-κB and AP-1 signaling in keratinocytes and mouse skin...
November 10, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27856220/the-biology-of-beta-human-papillomaviruses
#13
REVIEW
Massimo Tommasino
The beta genus comprises more than 50 beta human papillomavirus (HPV) types that are suspected to be involved, together with ultraviolet (UV) irradiation, in the development of non-melanoma skin cancer (NMSC), the most common form of human cancer. Two members of the genus beta, HPV5 and HPV8, were first identified in patients with a genetic disorder, epidermodysplasia verruciformis (EV), that confers high susceptibility to beta HPV infection and NMSC development. The fact that organ transplant recipients (OTRs) with an impaired immune system have an elevated risk of NMSC raised the hypothesis that beta HPV types may also be involved in skin carcinogenesis in non-EV patients...
November 14, 2016: Virus Research
https://www.readbyqxmd.com/read/27846199/height-height-related-snps-and-risk-of-non-melanoma-skin-cancer
#14
Xin Li, Liming Liang, Yen-Chen Anne Feng, Immaculata De Vivo, Edward Giovannucci, Jean Y Tang, Jiali Han
BACKGROUND: Adult height has been associated with risk of several site-specific cancers, including melanoma. However, less attention has been given to non-melanoma skin cancer (NMSC). METHODS: We prospectively examined the risk of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in relation to adult height in the Nurses' Health Study (NHS, n=117 863) and the Health Professionals Follow-up Study (HPFS, n=51 111). We also investigated the relationships between height-related genetic markers and risk of BCC and SCC in the genetic data sets of the NHS and HPFS (3898 BCC cases, and 8530 BCC controls; 527 SCC cases, and 8962 SCC controls)...
November 15, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27829204/mitochondrial-dna-deletion-percentage-in-sun-exposed-and-non-sun-exposed-skin
#15
Julia M Powers, Gillian Murphy, Nikki Ralph, Susan M O'Gorman, James E J Murphy
The percentages of mitochondrial genomes carrying the mtDNA(3895) and the mtDNA(4977) (common) deletion were quantified in sun exposed and non sun exposed skin biopsies, for five cohorts of patients varying either in sun exposure profile, age or skin cancer status. Non-melanoma skin cancer diagnoses are rising in Ireland and worldwide [12] but most risk prediction is based on subjective visual estimations of sun exposure history. A quantitative objective test for pre-neoplastic markers may result in better adherence to sun protective behaviours...
October 29, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27822110/the-danish-nonmelanoma-skin-cancer-dermatology-database
#16
REVIEW
Anna Lei Lamberg, Henrik Sølvsten, Ulrikke Lei, Gabrielle Randskov Vinding, Ida Marie Stender, Gregor Borut Ernst Jemec, Tine Vestergaard, Henrik Thormann, Merete Hædersdal, Tomas Norman Dam, Anne Braae Olesen
AIM OF DATABASE: The Danish Nonmelanoma Skin Cancer Dermatology Database was established in 2008. The aim of this database was to collect data on nonmelanoma skin cancer (NMSC) treatment and improve its treatment in Denmark. NMSC is the most common malignancy in the western countries and represents a significant challenge in terms of public health management and health care costs. However, high-quality epidemiological and treatment data on NMSC are sparse. STUDY POPULATION: The NMSC database includes patients with the following skin tumors: basal cell carcinoma (BCC), squamous cell carcinoma, Bowen's disease, and keratoacanthoma diagnosed by the participating office-based dermatologists in Denmark...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27782094/photodynamic-therapy-and-non-melanoma-skin-cancer
#17
REVIEW
Liezel L Griffin, John T Lear
Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen's disease (BD) and actinic keratosis (AK). A topical or systemic exogenous photosensitiser, results in selective uptake by malignant cells. Protoporphyrin IX (PpIX) is produced then activated by the introduction of a light source. Daylight-mediated MAL (methyl aminolaevulinate) PDT for AKs has the advantage of decreased pain and better patient tolerance...
October 22, 2016: Cancers
https://www.readbyqxmd.com/read/27782043/photodynamic-therapy-for-non-melanoma-skin-cancers
#18
REVIEW
Diana K Cohen, Peter K Lee
Non-melanoma skin cancer (NMSC) is traditionally treated with surgical excision. Nonsurgical methods such as cryotherapy and topical chemotherapeutics, amongst other treatments, are other options. Actinic keratosis (AKs) are considered precancerous lesions that eventually may progress to squamous cell carcinoma (SCC). Photodynamic therapy (PDT) offers an effective treatment for AKs, and is also effective for superficial basal cell carcinoma (BCC). Nodular BCC and Bowen's disease (SCC in situ) have shown acceptable response rates with PDT, although recurrence rates are higher for these two NMSC subtypes...
October 4, 2016: Cancers
https://www.readbyqxmd.com/read/27766546/management-of-skin-cancer-in-the-high-risk-patient
#19
James W Behan, Adam Sutton, Ashley Wysong
Skin cancer is the most common of human cancers and outnumbers all other types of cancer combined in the USA by over threefold. The majority of non-melanoma skin cancers are easily treated with surgery or locally destructive techniques performed under local anesthesia in the cost-effective outpatient setting. However, there is a subset of "high-risk" cases that prove challenging in terms of morbidity, mortality, adjuvant treatment required, as well as overall cost to the health care system. In our opinion, the term "high risk" when applied to skin cancer can mean one of three things: a high-risk tumor with aggressive histologic and/or clinical features with an elevated risk for local recurrence or regional/distant metastasis, a high-risk patient with the ongoing development of multiple skin cancers, and a high-risk patient based on immunosuppression...
December 2016: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/27729640/association-of-vegf-gene-polymorphisms-with-the-risk-and-prognosis-of-cutaneous-squamous-cell-carcinoma
#20
Xiao-Juan Nie, Wen-Min Liu, Li Zhang
BACKGROUND Cutaneous squamous cell carcinoma (cSCC) is the second most common type of non-melanoma skin cancer (NMSC) globally. The aims of this study were to further systematically clarify the potential association of rs833061 (-460 C>T) and rs1570360 (-1154 G>A), two SNPs of VEGF, with the risk of cSCC and the prognostic impacts on cSCC patients. MATERIAL AND METHODS This hospital-based case-control study analyzed peripheral venous blood collected from 100 cSCC patients and 124 healthy controls, and gathered personal information on patients...
October 12, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
keyword
keyword
10959
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"