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https://www.readbyqxmd.com/read/28343227/what-is-the-key-to-improving-renal-transplant-recipients-awareness-of-skin-cancer-risk
#1
Alessandro Borghi, Monica Corazza, Yuri Battaglia, Elisa Maietti, Sara Minghetti, Annarosa Virgili
BACKGROUND: Previous studies have shown poor compliance rates regarding sun protection among organ transplant recipients. OBJECTIVE: The main objective of the present study was to assess the awareness among renal transplant recipients (RTRs) of their risk of non-melanoma skin cancer (NMSC) development and their sunscreen use. The influence of several potentially relevant variables was also assessed in order to identify possible weak points on which to concentrate efforts in this respect...
March 25, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28321381/skull-base-invasion-patterns-and-survival-outcomes-of-nonmelanoma-skin-cancers
#2
Yusuf Dundar, Richard B Cannon, Marcus M Monroe, Luke Oliver Buchmann, Jason Patrick Hunt
Objective Report routes of skull base invasion for head and neck nonmelanoma skin cancers (NMSCs) and their survival outcomes. Design Retrospective. Participants Ninety patients with NMSC with skull base invasion between 2004 and 2014. Major Outcome Measures Demographic, tumor characteristics, and treatments associated with different types of skull base invasion and disease-specific survival (DSS) and overall survival (OS). Results Perineural invasion (PNI) to the skull base occurred in 69% of patients, whereas 38% had direct skull base invasion...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28301624/photodynamic-therapy-effectively-treats-actinic-keratoses-without-pre-illumination-incubation-time
#3
Jessica Gandy, Brian Labadie, Dina Bierman, Christopher Zachary
<p>BACKGROUND: Actinic keratoses (AKs) are dysplastic lesions of the epidermis that have the potential to progress to non-melanoma skin cancers (NMSC). Traditional photodynamic therapy (PDT) requires a pre-illumination incubation time, which adds to overall in-office time and has been linked to pain. Our group has found a novel protocol to effectively treat AKs with PDT that eliminates the pre-illumination incubation period and uses 2 back-to-back cycles of 16 minute 40 seconds.</p> <p>METHODS: The patient was prepped with soapy water and isopropyl alcohol, and thick AKs were descaled with a curette...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28294419/management-of-cancerization-field-with-a-medical-device-containing-photolyase-a-randomized-double-blind-parallel-group-pilot-study
#4
Elvira Moscarella, Giuseppe Argenziano, Caterina Longo, Sonia Aladren
At least 6 clinical studies conducted in subjects with actinic keratosis (AK) have demonstrated the therapeutic effect of Eryfotona AK-NMSC(®) (ISDIN, Spain), a topically applied film-forming cream containing DNA Repairsomes(™) (broad-spectrum UV filters and the DNA-repair enzyme photolyase, encapsulated in liposomes) (1-6) (registered as medical device in Europe). Recently a German opinion paper reviewed clinical evidence for the efficacy of topical application of this topical cream. They concluded that there was strong evidence that patient at high risk for developing AK would benefit from the year around use of this product marketed in Europe in the medical device category...
March 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28285366/nonmelanoma-skin-cancer-and-risk-of-all-cause-and-cancer-related-mortality-a-systematic-review
#5
Virginia Barton, Kent Armeson, Shalaka Hampras, Laura K Ferris, Kala Visvanathan, Dana Rollison, Anthony J Alberg
Some reports suggest that a history of nonmelanoma skin cancer (NMSC) may be associated with increased mortality. NMSCs have very low fatality rates, but the high prevalence of NMSC elevates the importance of the possibility of associated subsequent mortality from other causes. The variable methods and findings of existing studies leave the significance of these results uncertain. To provide clarity, we conducted a systematic review to characterize the evidence on the associations of NMSC with: (1) all-cause mortality, (2) cancer-specific mortality, and (3) cancer survival...
March 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28277539/epidermal-rac1-regulates-the-dna-damage-response-and-protects-from-uv-light-induced-keratinocyte-apoptosis-and-skin-carcinogenesis
#6
Jayesh Deshmukh, Ruth Pofahl, Ingo Haase
Non-melanoma skin cancer (NMSC) is the most common type of cancer. Increased expression and activity of Rac1, a small Rho GTPase, has been shown previously in NMSC and other human cancers; suggesting that Rac1 may function as an oncogene in skin. DMBA/TPA skin carcinogenesis studies in mice have shown that Rac1 is required for chemically induced skin papilloma formation. However, UVB radiation by the sun, which causes DNA damage, is the most relevant cause for NMSC. A potential role of Rac1 in UV-light-induced skin carcinogenesis has not been investigated so far...
March 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28257944/a-quantitative-study-of-in-vivo-protoporphyrin-ix-fluorescence-build-up-during-occlusive-treatment-phases
#7
C Louise Campbell, C Tom A Brown, Kenneth Wood, Ana Gabriela Salvio, Natalia M Inada, Vanderlei S Bagnato, Harry Moseley
BACKGROUND: Topical photodynamic therapy (PDT) is a non-invasive light based therapy used to treat non-melanoma skin cancer (NMSC) and dysplasia. During PDT, the light sensitive molecule protoporphyrin IX (PpIX) is activated, resulting in the production of singlet oxygen, which subsequently leads to cell death. PpIX is metabolised from a topically applied pro-drug and the strong fluorescence signal associated with PpIX can be utilised as an indicator of the amount of PpIX present within the tumour tissue...
February 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28257474/viruses-in-case-series-of-tumors-consistent-presence-in-different-cancers-in-the-same-subject
#8
Laila Sara Arroyo Mühr, Maria Hortlund, Zurab Bzhalava, Sara Nordqvist Kleppe, Davit Bzhalava, Emilie Hultin, Joakim Dillner
Studies investigating presence of viruses in cancer often analyze case series of cancers, resulting in detection of many viruses that are not etiologically linked to the tumors where they are found. The incidence of virus-associated cancers is greatly increased in immunocompromised individuals. Non-melanoma skin cancer (NMSC) is also greatly increased and a variety of viruses have been detected in NMSC. As immunosuppressed patients often develop multiple independent NMSCs, we reasoned that viruses consistently present in independent tumors might be more likely to be involved in tumorigenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28245638/impact-of-age-and-insulin-like-growth-factor-1-on-dna-damage-responses-in-uv-irradiated-human-skin
#9
REVIEW
Michael G Kemp, Dan F Spandau, Jeffrey B Travers
The growing incidence of non-melanoma skin cancer (NMSC) necessitates a thorough understanding of its primary risk factors, which include exposure to ultraviolet (UV) wavelengths of sunlight and age. Whereas UV radiation (UVR) has long been known to generate photoproducts in genomic DNA that promote genetic mutations that drive skin carcinogenesis, the mechanism by which age contributes to disease pathogenesis is less understood and has not been sufficiently studied. In this review, we highlight studies that have considered age as a variable in examining DNA damage responses in UV-irradiated skin and then discuss emerging evidence that the reduced production of insulin-like growth factor-1 (IGF-1) by senescent fibroblasts in the dermis of geriatric skin creates an environment that negatively impacts how epidermal keratinocytes respond to UVR-induced DNA damage...
February 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28240592/analysis-of-non-melanoma-skin-cancer-across-the-tofacitinib-rheumatoid-arthritis-clinical-programme
#10
Jeffrey R Curtis, Eun Bong Lee, George Martin, Xavier Mariette, Ketti K Terry, Yan Chen, Jamie Geier, John Andrews, Mandeep Kaur, Haiyun Fan, Chudy I Nduaka
OBJECTIVES: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We evaluated the incidence of non-melanoma skin cancer (NMSC) across the tofacitinib RA development programme. METHODS: NMSC events (through August 2013) were identified in patients receiving tofacitinib in two Phase (P)1, eight P2, six P3 and two long-term extension (LTE) studies. In P123 studies, tofacitinib was administered at various doses (1-30 mg twice daily [BID], 20 mg once daily), as monotherapy or with conventional synthetic disease-modifying anti-rheumatic drugs, mainly methotrexate...
February 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28239901/molecular-prevalence-of-merkel-cell-polyomavirus-in-nonmelanoma-skin-cancer-in-a-brazilian-population
#11
T R Bellott, C F Baez, S G Almeida, M T Venceslau, M G Zalis, M A Guimarães, M C Rochael, F B Luz, R B Varella, J R Almeida
BACKGROUND: Merkel cell polyomavirus (MCPyV), a newly described oncogenic virus, has been found in association with tumours other than Merkel cell carcinoma (MCC). As yet, little is known about the involvement or influence of MCPyV on the development of these tumours and its prevalence in various populations. AIM: To assess the prevalence of MCPyV DNA in cases of nonmelanoma skin cancer (NMSC). METHODS: The prevalence of MCPyV DNA was assessed in 96 cases of NMSC in a Brazilian population comprising 76 subjects, and these results were correlated with epidemiological and demographical data...
February 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28225789/non-melanoma-skin-cancer-and-risk-of-alzheimer-s-disease-and-all-cause-dementia
#12
Sigrun A J Schmidt, Anne G Ording, Erzsébet Horváth-Puhó, Henrik T Sørensen, Victor W Henderson
Cancer patients may be at decreased risk of Alzheimer's disease. This hypothesis is best developed for non-melanoma skin cancer (NMSC), but supportive epidemiological data are sparse. We therefore conducted a nationwide cohort study of the association between NMSC and Alzheimer's disease (main outcome) and all-cause dementia. Using Danish medical databases, we identified adults diagnosed with NMSC between 1 January 1980 and 30 November 2013 (n = 216,221) and a comparison cohort of five individuals matched to each NMSC patient by sex and birth year (n = 1,081,097)...
2017: PloS One
https://www.readbyqxmd.com/read/28218345/risk-of-non-melanoma-skin-cancer-in-patients-with-atopic-dermatitis-treated-with-oral-immunosuppressive-drugs
#13
Floor M Garritsen, Jorien van der Schaft, Juul M van den Reek, Klaziena Politiek, Harmieke van Os-Medendorp, Marijke van Dijk, Dirk J Hijnen, Marlies de Graaf, Carla A Bruijnzeel-Koomen, Elke M de Jong, Marie Louise Schuttelaar, Marjolein S Bruin-Weller
There is uncertainty about the risk of developing non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma (SCC), in patients with atopic dermatitis (AD) treated with oral immunosuppressive drugs. A total of 557 patients with AD treated with these drugs in the University Medical Center Utrecht and Groningen, the Netherlands, were analysed. NMSC after oral immunosuppressive treatment was reported in 18 patients (3.2%). The standardized incidence ratio for developing SCC was 13...
February 20, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28195452/practical-indications-for-the-management-of-non-melanoma-skin-cancer-patients
#14
Alessandro Di Stefani, Laura Del Regno, Alfredo Piccerillo, Ketty Peris
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), together encompassed in the term non--melanoma skin cancers (NMSC), are the most common cancers among fair--skinned populations. Individuating accurate risk stratification of NMSC patients is crucial to select different options among various treatment strategies. The majority of low risk NMSCs are easily treated with surgery, offering excellent cure rates and cosmetic results. Other treatment modalities include physical destruction (curettage, cautery and cryotherapy), chemical destruction (photodynamic therapy and topical 5--flurouracil) and immunomodulatory therapy (topical imiquimod)...
February 14, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28187193/comprehensive-measurement-of-uvb-induced-non-melanoma-skin-cancer-burden-in-mice-using-photographic-images-as-a-substitute-for-the-caliper-method
#15
Marc Bazin, Nupur K Purohit, Girish M Shah
The vernier caliper has been used as a gold standard to measure the length, width and height of skin tumors to calculate their total area and volume. It is a simple method for collecting data on a few tumors at a time, but becomes tedious, time-consuming and stressful for the animals and the operator when used for measuring multiple tumors in a large number of animals in protocols such as UVB-induced non-melanoma skin cancer (NMSC) in SKH-1 mice. Here, we show that photographic images of these mice taken within a few minutes under optimized conditions can be subjected to computerized analyses to determine tumor volume and area as accurately and precisely as the caliper method...
2017: PloS One
https://www.readbyqxmd.com/read/28162854/malignancy-rates-in-a-large-cohort-of-patients-with-systemically-treated-psoriasis-in-a-managed-care-population
#16
Maryam M Asgari, G Thomas Ray, Jamie L Geier, Charles P Quesenberry
BACKGROUND: Moderate to severe psoriasis often requires treatment with systemic agents, many of which have immunosuppressive properties and could increase cancer risk, including nonmelanoma skin cancer (NMSC). OBJECTIVE: We sought to estimate the overall malignancy rate (excluding NMSC) and NMSC rate among 5889 patients with systemically treated psoriasis. METHODS: We identified a cohort of adult Kaiser Permanente Northern California health plan members with psoriasis diagnosed from 1998 to 2011 and treated with at least 1 systemic antipsoriatic agent and categorized them into ever-biologic or nonbiologic users...
February 2, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28143815/long-term-safety-of-tofacitinib-for-the-treatment-of-rheumatoid-arthritis-up-to-8-5%C3%A2-years-integrated-analysis-of-data-from-the-global-clinical-trials
#17
Stanley B Cohen, Yoshiya Tanaka, Xavier Mariette, Jeffrey R Curtis, Eun Bong Lee, Peter Nash, Kevin L Winthrop, Christina Charles-Schoeman, Krishan Thirunavukkarasu, Ryan DeMasi, Jamie Geier, Kenneth Kwok, Lisy Wang, Richard Riese, Jürgen Wollenhaupt
OBJECTIVES: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We report an integrated safety summary of tofacitinib from two phase I, nine phase II, six phase III and two long-term extension studies in adult patients with active RA. METHODS: Data were pooled for all tofacitinib-treated patients (data cut-off: 31 March 2015). Incidence rates (IRs; patients with event/100 patient-years) and 95% CIs are reported for adverse events (AEs) of interest...
January 31, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28131793/rosacea-and-risk-of-cancer-in-denmark
#18
Alexander Egeberg, Joseph F Fowler, Gunnar H Gislason, Jacob P Thyssen
BACKGROUND: Rosacea is a common facial skin disorder with an estimated prevalence of 5-10% among Caucasians. OBJECTIVE: We compared cancer incidence in patients previously diagnosed with rosacea with that in the general population. METHODS: Nationwide cohort study of the Danish population using individual-level linkage of administrative registers. All Danish citizens aged ≥18years were followed from January 1st 2008 to December 31st 2012...
January 26, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28115960/non-melanoma-skin-cancer-treated-with-high-dose-rate-brachytherapy-a-review-of-literature
#19
REVIEW
Durim Delishaj, Agata Rembielak, Bruno Manfredi, Stefano Ursino, Francesco Pasqualetti, Concetta Laliscia, Francesca Orlandi, Riccardo Morganti, Maria Grazia Fabrini, Fabiola Paiar
PURPOSE: The incidence of non-melanoma skin cancer (NMSC) has been increasing over the past 30 years. There are different treatment options and surgical excision is the most frequent treatment due to its low rates of recurrence. Radiotherapy is an effective alternative of surgery, and brachytherapy (BT) might be a better therapeutic option due to high radiation dose concentration to the tumor with rapid dose fall-off resulting in normal tissues sparing. The aim of this review was to evaluate the local control, toxicity, and cosmetic outcomes in NMSC treated with high-dose-rate BT (HDR-BT)...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28114205/two-suturing-techniques-for-the-prevention-and-treatment-of-nasal-valve-collapse-after-mohs-micrographic-surgery
#20
Anis Miladi, Joseph W McGowan, Heidi B Donnelly
BACKGROUND: Tumor extirpation of nonmelanoma skin cancer (NMSC) adjacent to the alar groove, using Mohs micrographic surgery (MMS), may risk causing internal nasal valve (INV) collapse, resulting in reduced airflow during inspiration. There are many surgical options described in the literature to repair INV collapse as a postoperative corrective procedure, but few exist as an intra-operative preventative procedure. OBJECTIVE: The authors present 2 distinct methods to prevent and treat INV collapse during the repair of a perialar surgical defect caused by MMS...
January 20, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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