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https://www.readbyqxmd.com/read/28195452/practical-indications-for-the-management-of-non-melanoma-skin-cancer-patients
#1
Alessandro DI Stefani, Laura Del Regno, Alfredo Piccerillo, Ketty Peris
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), together encompassed in the term non--melanoma skin cancers (NMSC), are the most common cancers among fair--skinned populations. Individuating accurate risk stratification of NMSC patients is crucial to select different options among various treatment strategies. The majority of low risk NMSCs are easily treated with surgery, offering excellent cure rates and cosmetic results. Other treatment modalities include physical destruction (curettage, cautery and cryotherapy), chemical destruction (photodynamic therapy and topical 5--flurouracil) and immunomodulatory therapy (topical imiquimod)...
February 14, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28187193/comprehensive-measurement-of-uvb-induced-non-melanoma-skin-cancer-burden-in-mice-using-photographic-images-as-a-substitute-for-the-caliper-method
#2
Marc Bazin, Nupur K Purohit, Girish M Shah
The vernier caliper has been used as a gold standard to measure the length, width and height of skin tumors to calculate their total area and volume. It is a simple method for collecting data on a few tumors at a time, but becomes tedious, time-consuming and stressful for the animals and the operator when used for measuring multiple tumors in a large number of animals in protocols such as UVB-induced non-melanoma skin cancer (NMSC) in SKH-1 mice. Here, we show that photographic images of these mice taken within a few minutes under optimized conditions can be subjected to computerized analyses to determine tumor volume and area as accurately and precisely as the caliper method...
2017: PloS One
https://www.readbyqxmd.com/read/28162854/malignancy-rates-in-a-large-cohort-of-patients-with-systemically-treated-psoriasis-in-a-managed-care-population
#3
Maryam M Asgari, G Thomas Ray, Jamie L Geier, Charles P Quesenberry
BACKGROUND: Moderate to severe psoriasis often requires treatment with systemic agents, many of which have immunosuppressive properties and could increase cancer risk, including nonmelanoma skin cancer (NMSC). OBJECTIVE: We sought to estimate the overall malignancy rate (excluding NMSC) and NMSC rate among 5889 patients with systemically treated psoriasis. METHODS: We identified a cohort of adult Kaiser Permanente Northern California health plan members with psoriasis diagnosed from 1998 to 2011 and treated with at least 1 systemic antipsoriatic agent and categorized them into ever-biologic or nonbiologic users...
February 2, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28143815/long-term-safety-of-tofacitinib-for-the-treatment-of-rheumatoid-arthritis-up-to-8-5%C3%A2-years-integrated-analysis-of-data-from-the-global-clinical-trials
#4
Stanley B Cohen, Yoshiya Tanaka, Xavier Mariette, Jeffrey R Curtis, Eun Bong Lee, Peter Nash, Kevin L Winthrop, Christina Charles-Schoeman, Krishan Thirunavukkarasu, Ryan DeMasi, Jamie Geier, Kenneth Kwok, Lisy Wang, Richard Riese, Jürgen Wollenhaupt
OBJECTIVES: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We report an integrated safety summary of tofacitinib from two phase I, nine phase II, six phase III and two long-term extension studies in adult patients with active RA. METHODS: Data were pooled for all tofacitinib-treated patients (data cut-off: 31 March 2015). Incidence rates (IRs; patients with event/100 patient-years) and 95% CIs are reported for adverse events (AEs) of interest...
January 31, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28131793/rosacea-and-risk-of-cancer-in-denmark
#5
Alexander Egeberg, Joseph F Fowler, Gunnar H Gislason, Jacob P Thyssen
BACKGROUND: Rosacea is a common facial skin disorder with an estimated prevalence of 5-10% among Caucasians. OBJECTIVE: We compared cancer incidence in patients previously diagnosed with rosacea with that in the general population. METHODS: Nationwide cohort study of the Danish population using individual-level linkage of administrative registers. All Danish citizens aged ≥18years were followed from January 1st 2008 to December 31st 2012...
January 26, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28115960/non-melanoma-skin-cancer-treated-with-high-dose-rate-brachytherapy-a-review-of-literature
#6
REVIEW
Durim Delishaj, Agata Rembielak, Bruno Manfredi, Stefano Ursino, Francesco Pasqualetti, Concetta Laliscia, Francesca Orlandi, Riccardo Morganti, Maria Grazia Fabrini, Fabiola Paiar
PURPOSE: The incidence of non-melanoma skin cancer (NMSC) has been increasing over the past 30 years. There are different treatment options and surgical excision is the most frequent treatment due to its low rates of recurrence. Radiotherapy is an effective alternative of surgery, and brachytherapy (BT) might be a better therapeutic option due to high radiation dose concentration to the tumor with rapid dose fall-off resulting in normal tissues sparing. The aim of this review was to evaluate the local control, toxicity, and cosmetic outcomes in NMSC treated with high-dose-rate BT (HDR-BT)...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28114205/two-suturing-techniques-for-the-prevention-and-treatment-of-nasal-valve-collapse-after-mohs-micrographic-surgery
#7
Anis Miladi, Joseph W McGowan, Heidi B Donnelly
BACKGROUND: Tumor extirpation of nonmelanoma skin cancer (NMSC) adjacent to the alar groove, using Mohs micrographic surgery (MMS), may risk causing internal nasal valve (INV) collapse, resulting in reduced airflow during inspiration. There are many surgical options described in the literature to repair INV collapse as a postoperative corrective procedure, but few exist as an intra-operative preventative procedure. OBJECTIVE: The authors present 2 distinct methods to prevent and treat INV collapse during the repair of a perialar surgical defect caused by MMS...
January 20, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28107579/experience-of-skin-cancer-and-contact-with-health-professionals-is-associated-with-increased-skin-cancer-knowledge-but-not-sun-safety-knowledge-or-behaviour
#8
Charlotte L Thomas, Pablo Fernández Peñas
The mortality and morbidity associated with melanoma is unquestionable, but its global incidence is greatly outnumbered by that of non-melanoma skin cancer (NMSC). The economic burden of NMSC is significant, falling within the US' top five most costly cancers (1) . In Australia, a high level of skin cancer awareness has been reported (2) . Public health campaigns and advice provided by individual health professionals seek to increase knowledge about skin cancer, risk factors and protective sun-safety behaviours...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28095557/the-photodynamic-therapy-experience-of-a-high-volume-laser-and-dermatologic-surgery-center
#9
David E Orbuch, Lauren Penn, Bradley S Bloom, Jeremy A Brauer, Daniel B Shin, Joshua Greenbaum, Leonard J Bernstein, Elliot T Weiss, Robert T Anolik, Roy G Geronemus
BACKGROUND: Photodynamic therapy (PDT) is an FDA approved treatment for actinic keratoses (AK's) although multiple off-label indi- cations are reported. Despite frequent use for AK's, no clear consensus exists regarding protocols for overall treatment parameters. METHODS: Retrospective chart review of 1,491 subjects who underwent PDT between 2007 and 2011 at a high volume laser surgery center. Demographic information, clinical history, treatment data, and subsequent diagnosis of skin cancers were recorded...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28074526/risk-factors-for-nonmelanoma-skin-cancer-in-renal-transplant-recipients-a-case-control-study-from-a-reference-outpatient-clinic-in-southeast-brazil
#10
Flávia R Ferreira, Marilia M Ogawa, Luiz F C Nascimento, Jane Tomimori
BACKGROUND: Nonmelanoma skin cancer (NMSC) is the most common tumor in humans, and its incidence increases among renal transplant recipients (RTRs). The aims of this study were to characterize the RTRs with NMSC, to identify risk factors, and to calculate the probability of this tumor in this population. METHODS: This was a hospital-based case-control study. Epidemiological and clinical variables were evaluated. Hierarchical logistic regression was used, and a mathematical model was built...
February 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28063168/phytochemicals-for-the-prevention-of-photocarcinogenesis
#11
Mary Katherine Montes de Oca, Ross L Pearlman, Sarah F McClees, Rebecca Strickland, Farrukh Afaq
Ultraviolet (UV) exposure has an array of damaging effects and is the main cause of skin cancer in humans. Non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma, is the most common type of cancer. Incidence of NMSC has increased due to greater UV radiation, increased life expectancy, and other changes in lifestyle; the annual cost of skin cancer treatment in the United States has increased concurrently to around eight billion dollars. Because of these trends, novel approaches to skin cancer prevention have become an important area of research to decrease skin cancer morbidity and defray the costs associated with treatment...
January 7, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28056100/chimeric-l2-based-virus-like-particle-vlp-vaccines-targeting-cutaneous-human-papillomaviruses-hpv
#12
Bettina Huber, Christina Schellenbacher, Saeed Shafti-Keramat, Christoph Jindra, Neil Christensen, Reinhard Kirnbauer
Common cutaneous human papillomavirus (HPV) types induce skin warts, whereas species beta HPV are implicated, together with UV-radiation, in the development of non-melanoma skin cancer (NMSC) in immunosuppressed patients. Licensed HPV vaccines contain virus-like particles (VLP) self-assembled from L1 major capsid proteins that provide type-restricted protection against mucosal HPV infections causing cervical and other ano-genital and oro-pharyngeal carcinomas and warts (condylomas), but do not target heterologous HPV...
2017: PloS One
https://www.readbyqxmd.com/read/28055220/incident-diagnoses-of-non-melanoma-skin-cancer-active-component-u-s-armed-forces-2005-2014
#13
Terrence Lee, Stephen B Taubman, Valerie F Williams
From 1 January 2005 through 31 December 2014, a total of 8,819 incident diagnoses of non-melanoma skin cancer (NMSC) (incidence rate 64.6 cases per 100,000 person-years [p-yrs]) were documented in the health records of 6,670 active component service members. During the surveillance period, there was a very slight decrease in the annual crude incidence rates of NMSC; rates of NMSC peaked in 2007 (68.3 cases per 100,000 p-yrs) and were at their lowest in 2013 (60.4 cases per 100,000 p-yrs). Increasing age was associated with increased risk of NMSC...
December 2016: MSMR
https://www.readbyqxmd.com/read/28045204/increased-non-melanoma-skin-cancer-risk-in-young-patients-with-inflammatory-bowel-disease-on-immunomodulatory-therapy-a-retrospective-single-centre-cohort-study
#14
J Clowry, J Sheridan, R Healy, S Deady, D Keegan, K Byrne, G Cullen, H Mulcahy, H Comber, A C Parnell, G Doherty, A Lally
BACKGROUND: Recent studies report an increased risk of non-melanoma skin cancer (NMSC) in immunosuppressed patients with inflammatory bowel disease (IBD). Concurrently, paediatric IBD incidence is rising, with more patients now exposed to immunomodulators from a younger age. OBJECTIVES: To investigate NMSC incidence and to examine the risk associated with immunomodulators in the development of NMSC in patients with IBD. METHODS: This was a retrospective single centre cohort study...
January 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28040691/ultraviolet-radiation-and-kaposi-sarcoma-incidence-in-a-nationwide-us-cohort-of-hiv-infected-men
#15
Elizabeth K Cahoon, Eric A Engels, D Michal Freedman, Mary Norval, Ruth M Pfeiffer
BACKGROUND: Although ultraviolet radiation (UVR) is established as both an inducer of herpes simplex virus reactivation and as the primary risk factor for many common skin cancers, its relationship with human herpes virus 8 (HHV8) infection or risk of Kaposi sarcoma (KS) is unknown. METHODS: Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for the association between ambient UVR, history of nonmelanoma skin cancer (NMSC; as a biomarker of personal cumulative UVR dose), and incidence of first primary KS in a nationwide US cohort of white and African American male veterans infected with HIV between 1986 and 1996 (prior to the widespread availability of treatment) using Cox regression...
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28028856/british-association-of-dermatologists-national-audit-on-nonmelanoma-skin-cancer-excision-2014
#16
D J Keith, D A R de Berker, A P Bray, S T Cheung, A Brain, M F Mohd Mustapa
BACKGROUND: Diagnosis and management of nonmelanoma skin cancer (NMSC) represents a large part of the dermatology workload, and complete excision is a required surgical standard for treatment. AIM: To conduct an audit of the surgical practice for the treatment of NMSC by dermatologists in the UK. METHODS: Data on 10 consecutive nonmicrographic excisions of nonmelanoma skin cancer by UK dermatologists. Data collected included site, preoperative diagnosis, histological diagnosis, proximity to previous scars, and histological deep and peripheral margins...
January 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27997116/cross-linked-fluorescent-supramolecular-nanoparticles-as-finite-tattoo-pigments-with-controllable-intradermal-retention-times
#17
Jin-Sil Choi, Yazhen Zhu, Hongsheng Li, Parham Peyda, Thuy Tien Nguyen, Mo Yuan Shen, Yang Michael Yang, Jingyi Zhu, Mei Liu, Mandy M Lee, Shih-Sheng Sun, Yang Yang, Hsiao-Hua Yu, Kai Chen, Gary S Chuang, Hsian-Rong Tseng
Tattooing has been utilized by the medical community for precisely demarcating anatomic landmarks. This practice is especially important for identifying biopsy sites of nonmelanoma skin cancer (NMSC) due to the long interval (i.e., up to 3 months) between the initial diagnostic biopsy and surgical treatment. Commercially available tattoo pigments possess several issues, which include causing poor cosmesis, being mistaken for a melanocytic lesion, requiring additional removal procedures when no longer desired, and potentially inducing inflammatory responses...
December 20, 2016: ACS Nano
https://www.readbyqxmd.com/read/27932590/the-accuracy-of-measurements-of-nonmelanoma-skin-cancer-sizes-referred-to-the-mohs-surgery-clinic
#18
Derek To, Jillian Macdonald
BACKGROUND: Tumour size is a crucial factor used to plan Mohs procedures. Larger tumours require more time and stages of excision, and they need to be triaged as a higher priority. Therefore, the accuracy in measurement of tumour size is critical. OBJECTIVE: To investigate if there is a significant difference in accuracy of tumour measurements in referrals between dermatologists and nondermatologists. METHODS AND MATERIALS: Performed a retrospective study of 180 referrals from dermatologists and 47 referrals from nondermatologists to The Ottawa Hospital Riverside Mohs Surgery Clinic...
December 8, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27922162/nonmelanoma-skin-cancer-in-mountain-guides-high-prevalence-and-lack-of-awareness-warrant-development-of-evidence-based-prevention-tools
#19
Alexander Zink, Elisabeth Koch, Florian Seifert, Markus Rotter, Christoph D Spinner, Tilo Biedermann
AIMS OF THE STUDY: Nonmelanoma skin cancer (NMSC) is the most common cancer in Switzerland and Europe. The main causative factor is exposure to ultraviolet radiation, which puts outdoor workers in general at a higher risk of developing NMSC than indoor workers. However, few studies have clinically examined the risk of developing NMSC to outdoor workers, especially mountain guides. We aimed to investigate the prevalence of NMSC and corresponding precancerous lesions, and the associated risk behaviour of mountain and ski guides in order to develop future prevention programmes...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27898109/body-mass-index-and-risk-of-non-melanoma-skin-cancer-cumulative-evidence-from-prospective-studies
#20
Daijun Zhou, Jun Wu, Gaoxing Luo
Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A dose-response meta-analysis was conducted to quantitatively summarize the evidence. PubMed and Embase databases were searched for relevant studies. Study-specific relative risk (RR) and 95% confidence interval (CI) for an increase in BMI of 5 kg/m(2) was computed with the generalized least squares trend estimation, and these risk estimates were combined with the random-effects model...
November 29, 2016: Scientific Reports
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