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https://www.readbyqxmd.com/read/29775115/immunofluorescent-localization-of-non-myelinating-schwann-cells-and-their-interactions-with-immune-cells-in-mouse-thymus
#1
Dailun Hu, Philip K Nicholls, Changfu Yin, Khama Kelman, Qionglan Yuan, Wayne K Greene, Zhongli Shi, Bin Ma
The thymus is innervated by sympathetic/parasympathetic nerve fibers from the peripheral nervous system (PNS), suggesting a neural regulation of thymic function including T-cell development. Despite some published studies, data on the innervation and nerve-immune interaction inside the thymus remain limited. In the present study, we used immunofluorescent staining of glial fibrillary acidic protein (GFAP) coupled with confocal microscopy/three-dimensional (3D) reconstruction to reveal the distribution of non-myelinating Schwann cells (NMSC) and their interactions with immune cells inside mouse thymus...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29771903/incidence-demographics-and-surgical-outcomes-of-cutaneous-squamous-cell-carcinoma-diagnosed-in-northland-new-zealand
#2
Brodie M Elliott, Benjamin R Douglass, Daniel McConnell, Blair Johnson, Christopher Harmston
AIM: Non-melanoma skin cancer (NMSC) is the most commonly diagnosed and most costly cancer in Australasia. Cutaneous squamous cell carcinoma (cSCC) accounts for approximately 25% of NMSC. Despite this, reporting of cSCC is not mandatory in Australasia. This creates difficulties in planning, resourcing and improving outcomes in cSCC. Previous studies in New Zealand have lacked data on ethnicity. The aim of this study was to define the incidence and demographics of cSCC diagnosed in Northland, New Zealand, including data on ethnicity...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29770129/cutaneous-papillomaviruses-and-non-melanoma-skin-cancer-causal-agents-or-innocent-bystanders
#3
REVIEW
Daniel Hasche, Sabrina E Vinzón, Frank Rösl
There is still controversy in the scientific field about whether certain types of cutaneous human papillomaviruses (HPVs) are causally involved in the development of non-melanoma skin cancer (NMSC). Deciphering the etiological role of cutaneous HPVs requires - besides tissue culture systems - appropriate preclinical models to match the obtained results with clinical data from affected patients. Clear scientific evidence about the etiology and underlying mechanisms involved in NMSC development is fundamental to provide reasonable arguments for public health institutions to classify at least certain cutaneous HPVs as group 1 carcinogens...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29764888/assessment-of-thyroid-cancer-risk-associated-with-radiation-dose-from-personal-diagnostic-examinations-in-a-cohort-study-of-us-radiologic-technologists-followed-1983-2014
#4
Mark P Little, Hyeyeun Lim, Melissa C Friesen, Dale L Preston, Michele M Doody, Alice J Sigurdson, Gila Neta, Bruce H Alexander, Lienard A Chang, Elizabeth K Cahoon, Steven L Simon, Martha S Linet, Cari M Kitahara
OBJECTIVE: To assess whether personal medical diagnostic procedures over life, but particularly those associated with exposure in adulthood, were associated with increased thyroid cancer risk. DESIGN: Participants from the US Radiologic Technologists Study, a large, prospective cohort, were followed from the date of first mailed questionnaire survey completed during 1983-1989 to the earliest date of self-reported diagnosis of thyroid cancer or of any other cancer than non-melanoma skin cancer (NMSC) in any of three subsequent questionnaires up to the last in 2012-2014...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29752800/raman-biophysical-markers-in-skin-cancer-diagnosis
#5
Xu Feng, Austin J Moy, Hieu T M Nguyen, Yao Zhang, Jason Zhang, Matthew C Fox, Katherine R Sebastian, Jason S Reichenberg, Mia K Markey, James W Tunnell
Raman spectroscopy (RS) has demonstrated great potential for in vivo cancer screening; however, the biophysical changes that occur for specific diagnoses remain unclear. We recently developed an inverse biophysical skin cancer model to address this issue. Here, we presented the first demonstration of in vivo melanoma and nonmelanoma skin cancer (NMSC) detection based on this model. We fit the model to our previous clinical dataset and extracted the concentration of eight Raman active components in 100 lesions in 65 patients diagnosed with malignant melanoma (MM), dysplastic nevi (DN), basal cell carcinoma, squamous cell carcinoma, and actinic keratosis...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29746428/review-of-nonmelanoma-skin-cancer-in-african-americans-hispanics-and-asians
#6
Shauna Higgins, Azadeh Nazemi, Maggie Chow, Ashley Wysong
BACKGROUND: Skin cancer has traditionally been studied in Caucasian skin. Although it does occur with increased relative frequency in Caucasians, patients with skin of color suffer from elevated morbidity and mortality when diagnosed with skin cancer. OBJECTIVE: To detail the unique demographic and clinical features of nonmelanoma skin cancer (NMSC) in patients with skin of color, including Hispanic, African American, and Asian patients. MATERIALS AND METHODS: A complete PubMed search was conducted spanning dates from 1947 to June 2017 yielding a total of 185 manuscripts, from which 45 were included in this review...
May 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29742179/demographic-and-tumor-characteristics-of-patients-younger-than-50-years-with-nonmelanoma-skin-cancer-referred-for-mohs-micrographic-surgery
#7
Nicola A Quatrano, Euphemia W Mu, David E Orbuch, Adele Haimovic, Roy G Geronemus, Jeremy A Brauer
BACKGROUND: An increase in nonmelanoma skin cancer (NMSC) in younger patients has been reported. Many are treated with Mohs micrographic surgery (MMS). OBJECTIVE: Investigate patient and tumor characteristics in patients less than 50 years undergoing MMS for NMSC at a large, referral-based practice. METHODS & MATERIALS: Retrospective chart review of 1,332 tumors occurring in 1,018 consecutive patients over a five-year period. RESULTS: 81...
May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29733465/vascular-morphology-in-normal-skin-studied-with-dynamic-optical-coherence-tomography
#8
Pernille Lindsø Andersen, Jonas Olsen, Kersti Brosbøl Engelund Friis, Lotte Themstrup, Kasper Grandahl, Ole Steen Mortensen, Gregor Borut Ernst Jemec
BACKGROUND: Dynamic optical coherence tomography (D-OCT) is a non-invasive imaging technique, suitable for the study of structural and dynamic features of cutaneous microvasculature. Studies with D-OCT have primarily focused on non-melanoma skin cancer (NMSC) and a reference description of healthy skin is lacking. OBJECTIVE: To describe the prevalence of standard microvascular features in normal skin. METHOD: A total of 280 participants without skin disease were D-OCT scanned on four body locations; three sun-exposed areas and one unexposed: forehead, back of the neck, back of the hand and medial side of the upper arm...
May 7, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29705894/quality-of-life-in-patients-with-non-melanoma-skin-cancer-implications-for-healthcare-education-services-and-supports
#9
Robabeh Abedini, Maryam Nasimi, Pedram Noormohammad Pour, Atie Moghtadaie, Hamid Reza Tohidinik
Non-melanoma skin cancer (NMSC) is the most prevalent type of cancer among Caucasian populations worldwide. The purpose of this work was to measure quality of life (QOL) of the patients with diagnosis of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) who were referred to our cancer clinic. During 1 year, 95 patients were selected and asked to complete Dermatology Life Quality Index (DLQI) questionnaires. Ninety-five patients with NMSC (74 men and 21 women) with mean age of 64.6 ± 12.5 participated in this cross-sectional study...
April 28, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29701018/advances-in-optical-coherence-tomography-in-dermatology-a-review
#10
Jonas Olsen, Jon Holmes, Gregor B Jemec
Optical coherence tomography (OCT) was introduced as an imaging system, but like ultrasonography, other measures, such as blood perfusion and polarization of light, have enabled the technology to approach clinical utility. This review aims at providing an overview of the advances in clinical research based on the improving technical aspects. OCT provides cross-sectional and en face images down to skin depths of 0.4 to 2.00 mm with optical resolution of 3 to 15  μm. Dynamic optical coherence tomography (D-OCT) enables the visualization of cutaneous microvasculature via detection of rapid changes in the interferometric signal of blood flow...
April 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29698213/what-do-germans-want-to-know-about-skin-cancer-a-nationwide-google-search-analysis-from-2013-to-2017
#11
Stefanie Seidl, Barbara Schuster, Melvin Rüth, Tilo Biedermann, Alexander Zink
BACKGROUND: Experts worldwide agree that skin cancer is a global health issue, but only a few studies have reported on world populations' interest in skin cancer. Internet search data can reflect the interest of a population in different topics and thereby identify what the population wants to know. OBJECTIVE: Our aim was to assess the interest of the German population in nonmelanoma skin cancer (NMSC) and melanoma. METHODS: Google AdWords Keyword Planner was used to identify search terms related to NMSC and melanoma in Germany from November 2013 to October 2017...
April 13, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29695213/the-economic-burden-of-occupational-non-melanoma-skin-cancer-due-to-solar-radiation
#12
Amirabbas Mofidi, Emile Tompa, James Spencer, Christina Kalcevich, Cheryl E Peters, Joanne Kim, Chaojie Song, Seyed Bagher Mortazavi, Paul A Demers
Solar ultraviolet (UV) radiation is the second most prevalent carcinogenic exposure in Canada and is similarly important in other countries with large Caucasian populations. The objective of this article was to estimate the economic burden associated with newly diagnosed non-melanoma skin cancers (NMSCs) attributable to occupational solar radiation exposure. Key cost categories considered were direct costs (healthcare costs, out-of-pocket costs (OOPCs), and informal caregiver costs); indirect costs (productivity/output costs and home production costs); and intangible costs (monetary value of the loss of health-related quality of life (HRQoL))...
April 25, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29691768/skin-cancer-following-solid-organ-transplantation-a-review-of-risk-factors-and-models-of-care
#13
REVIEW
Matthew D Howard, John C Su, Alvin H Chong
The number of solid organ transplants has been increasing annually worldwide. Advances in transplantation surgery and community awareness of organ donation have been key contributors. Combined with increased understanding of immunosuppression, there are a growing number of solid organ transplant recipients in the community as a result of improved long-term outcomes. There remains a high incidence of deaths worldwide post-transplant due to non-melanoma skin cancer (NMSC), which has greater morbidity and mortality in this population than in the general community...
April 24, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29683285/long-term-efficacy-data-for-daylight-pdt
#14
Maria C Fargnoli
INTRODUCTION: Conventional photodynamic therapy (c-PDT) is an established successful treatment for non-melanoma skin cancers (NMSC). Daylight PDT (DL-PDT) was introduced to overcome the main inconveniencies associated with c-PDT such as pain during illumination and long clinic visits. DL-PDT was shown to have similar short-term efficacy to c-PDT for the treatment of mild/moderate AKs but it is associated with better tolerability. Since AKs tend to regress and reoccur over time, data on long-term efficacy of DL-PDT become crucial...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29661854/targeting-toll-like-receptors-in-cancer-prevention
#15
EDITORIAL
Karen S Sfanos
There is a pressing need for the development of new prevention strategies for the most common worldwide malignancy, nonmelanoma skin cancer (NMSC), as sun protection efforts have not proven to be completely effective. Interestingly, despite the known circumstance that individuals undergoing chronic immunosuppression are at a substantially increased risk for developing NMSC, in this issue of Cancer Prevention Research , Blohm-Mangone and colleagues provide new evidence that topical application of the Toll-like receptor 4 (TLR4) antagonist resatorvid may be efficacious as a chemopreventive agent in NMSC specifically via blocking UV-induced inflammatory signaling...
April 16, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29594182/model-based-quantitative-optical-biopsy-in-multilayer-in-vitro-soft-tissue-models-for-whole-field-assessment-of-nonmelanoma-skin-cancer
#16
Bala Nivetha Kanakaraj, Sujatha Narayanan Unni
Optical techniques such as fluorescence and diffuse reflectance spectroscopy are proven to have the potential to provide tissue discrimination during the development of malignancies and hence treated as potential tools for noninvasive optical biopsy in clinical diagnostics. Quantitative optical biopsy is challenging and hence the majority of the existing strategies are based on a qualitative assessment of the concerned tissue. Light-tissue interaction models as well as precise optical phantoms can greatly help in the former and here we present a pilot study to assess the optical properties of a multilayer tissue-specific optical phantom with the help of a database generated using multilayer-Monte Carlo (MCML) models...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29577672/cancer-risk-in-patients-with-alopecia-areata-a-nationwide-population-based-matched-cohort-study
#17
Chih-Chiang Chen, Yun-Ting Chang, Han-Nan Liu, Yi-Ju Chen
Alopecia areata (AA) is an organ-specific autoimmune disorder. Defective immune system related disorders are prone to increase the risk of cancer formation. However, the association among AA and variety of cancer types had never been studied. A nationwide population-based matched cohort study was conducted to evaluate the cancer risk in patients with AA. Records from Taiwan National Health Insurance Research Database were analyzed. Cases of AA from 1997 to 2013 and cancers registered in the catastrophic illness profile from the same time period were collected...
March 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29575799/sentinel-lymph-node-biopsy-in-33-non-melanoma-skin-cancers-of-the-head-and-neck-a-twelve-year-experience-with-long-term-follow-up
#18
LETTER
J P Foy, F Kolb, E Routier, A Cavalcanti, J Lumbroso, G Tomasic, C Mateus, S Temam, C Robert, A Moya-Plana
No abstract text is available yet for this article.
March 24, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29573497/inverse-association-for-diagnosis-of-alzheimer-s-disease-subsequent-to-both-melanoma-and-non-melanoma-skin-cancers-in-a-large-urban-single-center-midwestern-u-s-patient-population
#19
Erin Ibler, Gary Tran, Kelsey A Orrell, Linda Serrano, Sara Majewski, Kimberly A Sable, Rebecca Thiede, Anne E Laumann, Dennis P West, Beatrice Nardone
BACKGROUND: Although literature demonstrates a decreased risk of Alzheimer's disease (AD) in individuals with various cancers, including squamous cell cancers (SCC) and basal cell cancers (BCC) comprising non-melanoma skin cancers (NMSC), there is a paucity of literature to substantiate an association between malignant melanoma (MM) and AD. OBJECTIVE: The aim of this study is to determine if an association exists between MM and AD as well as for NMSC and AD. METHODS: A large urban, Midwestern, U...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29566922/nonsurgical-treatment-of-nonmelanoma-skin-cancer-in-the-mature-patient
#20
Romana Čeović, Mikela Petković, Zrinka Bukvić Mokos, Krešimir Kostović
Nonmelanoma skin cancer (NMSC) is the most common cancer, with the median age at NMSC diagnosis is 71 years. Treatment options for NMSC include surgical therapy, which is usually the first-choice treatment, and nonsurgical modalities. Therapeutic modalities depend on tumor localization, histologic type, and biologic behavior, as well as patient comorbidities, age, and life expectancy. Nonsurgical treatments include cryotherapy, local therapies (imiquimod, 5-fluorouracil, ingenol mebutate, and diclofenac), photodynamic therapy, radiotherapy, and hedgehog inhibitors...
March 2018: Clinics in Dermatology
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