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https://www.readbyqxmd.com/read/28757485/francis-bacon-s-i-valerius-terminus-i-and-the-voyage-to-the-great-instauration
#1
Richard Serjeantson
Francis Bacon's earliest surviving natural philosophical treatise (composed circa 1603) bears the title Valerius Terminus of the Interpretation of Nature. This study, resting on fresh attention to the surviving authorial manuscript, has three goals. It begins by identifying a lost precursor work apparently entitled "Of Active Knowledge." It then examines the significance of the pseudonyms Bacon chose to introduce his ideas, considering especially his invocation of Erasmus's emblem, the Roman deity Terminus...
2017: Journal of the History of Ideas
https://www.readbyqxmd.com/read/28753364/novel-cosmic-ray-electron-and-positron-constraints-on-mev-dark-matter-particles
#2
Mathieu Boudaud, Julien Lavalle, Pierre Salati
MeV dark matter (DM) particles annihilating or decaying to electron-positron pairs cannot, in principle, be observed via local cosmic-ray (CR) measurements because of the shielding solar magnetic field. In this Letter, we take advantage of spacecraft Voyager 1's capacity for detecting interstellar CRs since it crossed the heliopause in 2012. This opens up a new avenue to probe DM in the sub-GeV energy/mass range that we exploit here for the first time. From a complete description of the transport of electrons and positrons at low energy, we derive predictions for both the secondary astrophysical background and the pair production mechanisms relevant to DM annihilation or decay down to the MeV mass range...
July 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28743677/maiden-voyage-of-the-collaborative-cross-mouse-exploring-variability-in-animals-response-to-perchloroethylene
#3
Charles W Schmidt
No abstract text is available yet for this article.
July 24, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28741379/tiny-rnas-and-their-voyage-via-extracellular-vesicles-secretion-of-bacterial-small-rna-and-eukaryotic-microrna
#4
Ji-Woong Choi, Jee-Hyun Um, Jin-Hyun Cho, Heon-Jin Lee
MicroRNAs are small non-coding RNAs that bind to the 3'-untranslated region of target mRNAs and have transcriptional or translational inhibitory function in eukaryotes. Before microRNAs were widely known, bacterial non-coding small RNAs around 50-200 nt in length were discovered whose mechanism of action resembled that of microRNAs. Recently, RNAs that are of similar size to or smaller than microRNAs have been discovered in bacteria and indeed, this class of small RNAs have been found throughout all domains of life...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28691800/three-lessons-for-the-microplastics-voyage
#5
David Sedlak
No abstract text is available yet for this article.
July 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28689044/voyaging-into-the-third-dimension-a-perspective-on-virtual-methods-and-their-application-to-studies-of-juvenile-sex-estimation-and-the-ontogeny-of-sexual-dimorphism
#6
REVIEW
L A B Wilson, L T Humphrey
In contrast to the well-established and highly accurate morphological methods available for sexing adult skeletons, juvenile sex estimation is widely recognised as a difficult task that faces a series of challenges. The acquisition of 3D data, and construction of 3D models from volume or surface scans, has become increasingly common in forensic sciences, and these data offer considerable opportunity for the development and refinement of methods in sex estimation. The suitability and potential of virtual methods for juvenile sex estimation are evaluated with the aims of identifying (1) the benefits and challenges associated with virtual data and quantitative analysis of 3D models, and (2) pathways that may lead to practical improvements for sexing juveniles...
June 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28660617/exploring-the-core-of-crew-resource-management-course-speak-up-or-stay-silent
#7
Roar Espevik, Evelyn Rose Saus, Olav Kjellvold Olsen
The Norwegian Costal Express travels 24/7 along a coast considered as one of the most dangerous littoral areas of the world. It is crucial for safe voyage to speak up when one of the crewmembers discovers a discrepancy or vital new information to the passage that needs to be shared and acted upon. Crew resource management courses are intended to increase safety and we suggest that the key is to enhance the ability to speak up. Watch keepers valued a 4-h course intended to enhance the ability to speak up and improve listening skills as highly relevant (89%) and educational (69%)...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28660614/seafarers-depression-and-suicide
#8
Alex Mellbye, Tim Carter
This review assesses available evidence on the frequency of and trends in depression and suicide among seafarers. Investigations of depression and suicide are scarce and the findings are inconsistent, they do, nevertheless, show indications of improvement although some recent case series do indicate that suicide remains a problem. A review of additional indicators for mental distress and lack of wellbeing supports the decline in frequency of problems, but nuances this in terms of the relative risks in different groups of seafarers, showing internal variations in the frequency of mental health issues among seafarers, with markers such as rank, type of voyage, gender, age, nationality and crew multiculturalism being relevant variables...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28639011/guselkumab-for-the-treatment-of-psoriasis-a-review-of-phase-iii-trials
#9
REVIEW
Mio Nakamura, Katherine Lee, Caleb Jeon, Sahil Sekhon, Ladan Afifi, Di Yan, Kristina Lee, Tina Bhutani
INTRODUCTION: Interleukin (IL)-23 inhibitors are a new class of biologics currently undergoing clinical trials for the treatment of moderate-to-severe psoriasis. Phase III studies of guselkumab, an IL-23 receptor monoclonal antibody, are currently underway. METHODS: We summarize the available phase III results to date, establishing the efficacy and safety of guselkumab in patients with moderate-to-severe plaque psoriasis. RESULTS: Currently, there are available data of up to 48 weeks from two Phase III, multicenter, randomized, double-blind, placebo- and comparator-controlled clinical trials, VOYAGE 1 and VOYAGE 2...
June 21, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28638964/ships-ballast-water-treatment-by-chlorination-can-generate-toxic-trihalomethanes
#10
Marco R Hernandez, Nargis Ismail, Ken G Drouillard, Hugh J MacIsaac
The International Maritime Organization (IMO) will enforce a new abundance-based performance standard for ballast water in September, 2017. Strong oxidants, like chlorine, have been proposed as a method for achieving this standard. However chlorine treatment of ballast water can produce hazardous trihalomethanes. We assessed maximum trihalomethane production from one chlorine dose for three types of ballast water (fresh, brackish and marine) and three levels of total organic carbon (TOC) concentration (natural, filtered, enhanced)...
June 21, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28633358/phylogeography-of-herbarium-specimens-of-asexually-propagated-paper-mulberry-broussonetia-papyrifera-l-l-h%C3%A3-r-ex-vent-moraceae-reveals-genetic-diversity-across-the-pacific
#11
Claudia Payacan, Ximena Moncada, Gloria Rojas, Andrew Clarke, Kuo-Fang Chung, Robin Allaby, Daniela Seelenfreund, Andrea Seelenfreund
Background and Aims: Paper mulberry or Broussonetia papyrifera (L.) L'Hér. ex Vent. (Moraceae) is a dioecious species native to continental South-east Asia and East Asia, including Taiwan, that was introduced to the Pacific by pre-historic voyagers and transported intentionally and propagated asexually across the full range of Austronesian expansion from Taiwan to East Polynesia. The aim of this study was to gain insight into the dispersal of paper mulberry into Oceania through the genetic analysis of herbaria samples which represent a more complete coverage of the historical geographical range of the species in the Pacific before later introductions and local extinctions occurred...
June 14, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28625674/regional-cerebral-cortical-thickness-correlates-with-autonomic-outflow
#12
REVIEW
Katelyn N Wood, Mark B Badrov, Mark R Speechley, J Kevin Shoemaker
Dysregulation of autonomic control often develops with advancing age, favoring a chronic state of heightened sympathetic outflow with parasympathetic withdrawal. However, the mechanisms of this age-related autonomic impairment are not known. This study tested the hypothesis that inter-individual differences in autonomic outflow across the adult age-span are related to cerebral cortex thickness. A total of 55 healthy, active individuals participated in this study (21-73years; 18 female). Physical fitness was treated as a possible covariate (VO2peak: 26-81mL/kg/min)...
June 7, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28610077/two-bathyal-hydroids-hydrozoa-leptothecata-from-the-southwest-indian-ocean
#13
Jeanette E Watson
Two species of hydroids were recovered from a mooring rope and experimentally deployed whale bone attached to an underwater transponder buoy at a depth of 732 m on the Coral Seamount on the Southwest Indian Ocean Ridge (41° 22.31'S, 54° 57'E) in the Southern Indian Ocean. The material was collected approximately 1,500 km south south-east of Madagascar during Voyage JC066 of the British Royal Research Ship R.R.S. James Cook on 20/11/2011. Hydroids were collected from the mooring rope and whale bone on board the ship after underwater retrieval by ROV...
March 27, 2017: Zootaxa
https://www.readbyqxmd.com/read/28511938/floating-marine-litter-as-a-raft-for-drifting-voyages-for-planes-minutus-crustacea-decapoda-grapsidae-and-liocarcinus-navigator-crustacea-decapoda-polybiidae
#14
P Tutman, K Kapiris, M Kirinčić, A Pallaoro
The Columbus crab Planes minutus and Arch-fronted swimming crab Liocarcinus navigator, within their distribution ranges in the Mediterranean, were found rafted on plastic macro-litter floating on the open south Adriatic. While P. minutus was recorded from inanimate flotsam outside of the Mediterranean, L. navigator is herein reported for the first time on floating marine litter. The role of floating litter as habitat or as a dispersal agent for marine invertebrates has received quite attention however, records of decapod crabs drifting on litter has been relatively sparse...
May 13, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28490795/performances-of-kevlar-and-polyethylene-as-radiation-shielding-on-board-the-international-space-station-in-high-latitude-radiation-environment
#15
Livio Narici, Marco Casolino, Luca Di Fino, Marianna Larosa, Piergiorgio Picozza, Alessandro Rizzo, Veronica Zaconte
Passive radiation shielding is a mandatory element in the design of an integrated solution to mitigate the effects of radiation during long deep space voyages for human exploration. Understanding and exploiting the characteristics of materials suitable for radiation shielding in space flights is, therefore, of primary importance. We present here the results of the first space-test on Kevlar and Polyethylene radiation shielding capabilities including direct measurements of the background baseline (no shield)...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428377/scientists-hope-risky-winter-voyage-yields-icy-rewards
#16
Warren Cornwall
No abstract text is available yet for this article.
April 21, 2017: Science
https://www.readbyqxmd.com/read/28411176/hematopoietic-stem-cell-transplant-for-a-new-primary-immunodeficiency-disorder-a-voyage-where-no-transplant-physician-has-gone-before
#17
James A Connelly
No abstract text is available yet for this article.
April 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28390441/-transporting-thought-cultures-of-balloon-flight-in-britain-1784-1785
#18
Caitlín Róisín Doherty
The balloon has long drifted through popular discourse as a symbol of an Enlightenment attitude towards discovery and a Romanticized image of rationality. This article uses two accounts of early British balloon voyages, both published in 1786, and through them attempts to understand the wide range of practices - literary, social, chemical and adventurous - employed by early balloonists in Britain. I argue that the two series of flights recorded by John Jeffries and Vincenzo Lunardi can be read to show two different philosophical ideas of and aspirations for ballooning, each of which is tied to a different British location, and established a different paradigm for the public reception of flight experiments in later years...
April 9, 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/28377319/development-of-extended-voyaging-anti-oxidant-linked-amphiphilic-polymeric-nanomicelles-for-anti-tuberculosis-drug-delivery
#19
Rajendran Amarnath Praphakar, Murugan A Munusamy, Mariappan Rajan
Amphiphilic chitosan-graft-poly(caprolactone)/(ferulic acid) (CS-g-PCL/FA) multi-co-polymers were fabricated by microwave-assisted ring opening polymerization followed by an 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide (EDC)-mediated coupling reaction and characterized by Fourier transformed infrared (FTIR) spectroscopy. Graft copolymers self-assembled into nanomicelles, and were able to incorporate rifampicin (RF) into their hydrophobic inner cores. X-ray diffraction (XRD) patterns were applied to characterize the crystal structures of graft polymers and the effects of RF on micelle morphology...
April 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28294555/promise-and-peril-in-nanomedicine-the-challenges-and-needs-for-integrated-systems-biology-approaches-to-define-health-risk
#20
REVIEW
Sabina Halappanavar, Ulla Vogel, Hakan Wallin, Carole L Yauk
In the 1966s visionary film 'Fantastic Voyage' a submarine crew was shrunk to 100 nm in size and injected into the body of an injured scientist to repair his damaged brain. The movie (written by Harry Kleiner; directed by Richard Fleischer; novel by Isaac Asimov) drew attention to the potential power of engineered nanoscale structures and devices to construct, monitor, control, treat, and repair individual cells. Even more interesting was the fact that the film elegantly noted that the structure had to be miniaturized to a size that is not detected by the body's immune surveillance system, and highlighted the many physiological barriers that are encountered on the submarine's long journey to the target...
March 15, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
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