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https://www.readbyqxmd.com/read/28639011/guselkumab-for-the-treatment-of-psoriasis-a-review-of-phase-iii-trials
#1
REVIEW
Mio Nakamura, Katherine Lee, Caleb Jeon, Sahil Sekhon, Ladan Afifi, Di Yan, Kristina Lee, Tina Bhutani
INTRODUCTION: Interleukin (IL)-23 inhibitors are a new class of biologics currently undergoing clinical trials for the treatment of moderate-to-severe psoriasis. Phase III studies of guselkumab, an IL-23 receptor monoclonal antibody, are currently underway. METHODS: We summarize the available phase III results to date, establishing the efficacy and safety of guselkumab in patients with moderate-to-severe plaque psoriasis. RESULTS: Currently, there are available data of up to 48 weeks from two Phase III, multicenter, randomized, double-blind, placebo- and comparator-controlled clinical trials, VOYAGE 1 and VOYAGE 2...
June 21, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28638964/ships-ballast-water-treatment-by-chlorination-can-generate-toxic-trihalomethanes
#2
Marco R Hernandez, Nargis Ismail, Ken G Drouillard, Hugh J MacIsaac
The International Maritime Organization (IMO) will enforce a new abundance-based performance standard for ballast water in September, 2017. Strong oxidants, like chlorine, have been proposed as a method for achieving this standard. However chlorine treatment of ballast water can produce hazardous trihalomethanes. We assessed maximum trihalomethane production from one chlorine dose for three types of ballast water (fresh, brackish and marine) and three levels of total organic carbon (TOC) concentration (natural, filtered, enhanced)...
June 21, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28633358/phylogeography-of-herbarium-specimens-of-asexually-propagated-paper-mulberry-broussonetia-papyrifera-l-l-h%C3%A3-r-ex-vent-moraceae-reveals-genetic-diversity-across-the-pacific
#3
Claudia Payacan, Ximena Moncada, Gloria Rojas, Andrew Clarke, Kuo-Fang Chung, Robin Allaby, Daniela Seelenfreund, Andrea Seelenfreund
Background and Aims: Paper mulberry or Broussonetia papyrifera (L.) L'Hér. ex Vent. (Moraceae) is a dioecious species native to continental South-east Asia and East Asia, including Taiwan, that was introduced to the Pacific by pre-historic voyagers and transported intentionally and propagated asexually across the full range of Austronesian expansion from Taiwan to East Polynesia. The aim of this study was to gain insight into the dispersal of paper mulberry into Oceania through the genetic analysis of herbaria samples which represent a more complete coverage of the historical geographical range of the species in the Pacific before later introductions and local extinctions occurred...
June 14, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28625674/regional-cerebral-cortical-thickness-correlates-with-autonomic-outflow
#4
REVIEW
Katelyn N Wood, Mark B Badrov, Mark R Speechley, J Kevin Shoemaker
Dysregulation of autonomic control often develops with advancing age, favoring a chronic state of heightened sympathetic outflow with parasympathetic withdrawal. However, the mechanisms of this age-related autonomic impairment are not known. This study tested the hypothesis that inter-individual differences in autonomic outflow across the adult age-span are related to cerebral cortex thickness. A total of 55 healthy, active individuals participated in this study (21-73years; 18 female). Physical fitness was treated as a possible covariate (VO2peak: 26-81mL/kg/min)...
June 7, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28610077/two-bathyal-hydroids-hydrozoa-leptothecata-from-the-southwest-indian-ocean
#5
Jeanette E Watson
Two species of hydroids were recovered from a mooring rope and experimentally deployed whale bone attached to an underwater transponder buoy at a depth of 732 m on the Coral Seamount on the Southwest Indian Ocean Ridge (41° 22.31'S, 54° 57'E) in the Southern Indian Ocean. The material was collected approximately 1,500 km south south-east of Madagascar during Voyage JC066 of the British Royal Research Ship R.R.S. James Cook on 20/11/2011. Hydroids were collected from the mooring rope and whale bone on board the ship after underwater retrieval by ROV...
March 27, 2017: Zootaxa
https://www.readbyqxmd.com/read/28511938/floating-marine-litter-as-a-raft-for-drifting-voyages-for-planes-minutus-crustacea-decapoda-grapsidae-and-liocarcinus-navigator-crustacea-decapoda-polybiidae
#6
P Tutman, K Kapiris, M Kirinčić, A Pallaoro
The Columbus crab Planes minutus and Arch-fronted swimming crab Liocarcinus navigator, within their distribution ranges in the Mediterranean, were found rafted on plastic macro-litter floating on the open south Adriatic. While P. minutus was recorded from inanimate flotsam outside of the Mediterranean, L. navigator is herein reported for the first time on floating marine litter. The role of floating litter as habitat or as a dispersal agent for marine invertebrates has received quite attention however, records of decapod crabs drifting on litter has been relatively sparse...
May 13, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28490795/performances-of-kevlar-and-polyethylene-as-radiation-shielding-on-board-the-international-space-station-in-high-latitude-radiation-environment
#7
Livio Narici, Marco Casolino, Luca Di Fino, Marianna Larosa, Piergiorgio Picozza, Alessandro Rizzo, Veronica Zaconte
Passive radiation shielding is a mandatory element in the design of an integrated solution to mitigate the effects of radiation during long deep space voyages for human exploration. Understanding and exploiting the characteristics of materials suitable for radiation shielding in space flights is, therefore, of primary importance. We present here the results of the first space-test on Kevlar and Polyethylene radiation shielding capabilities including direct measurements of the background baseline (no shield)...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428377/scientists-hope-risky-winter-voyage-yields-icy-rewards
#8
Warren Cornwall
No abstract text is available yet for this article.
April 21, 2017: Science
https://www.readbyqxmd.com/read/28411176/hematopoietic-stem-cell-transplant-for-a-new-primary-immunodeficiency-disorder-a-voyage-where-no-transplant-physician-has-gone-before
#9
James A Connelly
No abstract text is available yet for this article.
April 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28390441/-transporting-thought-cultures-of-balloon-flight-in-britain-1784-1785
#10
Caitlín Róisín Doherty
The balloon has long drifted through popular discourse as a symbol of an Enlightenment attitude towards discovery and a Romanticized image of rationality. This article uses two accounts of early British balloon voyages, both published in 1786, and through them attempts to understand the wide range of practices - literary, social, chemical and adventurous - employed by early balloonists in Britain. I argue that the two series of flights recorded by John Jeffries and Vincenzo Lunardi can be read to show two different philosophical ideas of and aspirations for ballooning, each of which is tied to a different British location, and established a different paradigm for the public reception of flight experiments in later years...
April 9, 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/28377319/development-of-extended-voyaging-anti-oxidant-linked-amphiphilic-polymeric-nanomicelles-for-anti-tuberculosis-drug-delivery
#11
Rajendran Amarnath Praphakar, Murugan A Munusamy, Mariappan Rajan
Amphiphilic chitosan-graft-poly(caprolactone)/(ferulic acid) (CS-g-PCL/FA) multi-co-polymers were fabricated by microwave-assisted ring opening polymerization followed by an 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide (EDC)-mediated coupling reaction and characterized by Fourier transformed infrared (FTIR) spectroscopy. Graft copolymers self-assembled into nanomicelles, and were able to incorporate rifampicin (RF) into their hydrophobic inner cores. X-ray diffraction (XRD) patterns were applied to characterize the crystal structures of graft polymers and the effects of RF on micelle morphology...
April 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28294555/promise-and-peril-in-nanomedicine-the-challenges-and-needs-for-integrated-systems-biology-approaches-to-define-health-risk
#12
REVIEW
Sabina Halappanavar, Ulla Vogel, Hakan Wallin, Carole L Yauk
In the 1966s visionary film 'Fantastic Voyage' a submarine crew was shrunk to 100 nm in size and injected into the body of an injured scientist to repair his damaged brain. The movie (written by Harry Kleiner; directed by Richard Fleischer; novel by Isaac Asimov) drew attention to the potential power of engineered nanoscale structures and devices to construct, monitor, control, treat, and repair individual cells. Even more interesting was the fact that the film elegantly noted that the structure had to be miniaturized to a size that is not detected by the body's immune surveillance system, and highlighted the many physiological barriers that are encountered on the submarine's long journey to the target...
March 15, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28266086/how-much-impact-do-gains-in-height-have-on-shoulder-breadths-within-taiwanese-families
#13
Bruce Floyd
OBJECTIVES: This study investigates allometric changes in shoulder breadths relative to changes in stature arising from rapidly changing developmental circumstances within 107 Taiwanese families. It speaks to broader issues related to the extent of phenotypic plasticity of body breadths humans are capable of in response to reductions in developmental stressors. METHODS: An examination of relationships between shoulder breadth and height within individuals in each generation was followed by evaluation of patterns of difference between same-sex parent-offspring pairs in height and shoulder breadth...
March 7, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28252403/the-subspace-voyager-exploring-high-dimensional-data-along-a-continuum-of-salient-3d-subspace
#14
Bing Wang, Klaus Mueller
Analyzing high-dimensional data and finding hidden patterns is a difficult problem and has attracted numerous research efforts. Automated methods can be useful to some extent but bringing the data analyst into the loop via interactive visual tools can help the discovery process tremendously. An inherent problem in this effort is that humans lack the mental capacity to truly understand spaces exceeding three spatial dimensions. To keep within this limitation, we describe a framework that decomposes a high-dimensional data space into a continuum of generalized 3D subspaces...
February 23, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28241745/drug-voyager-a-computational-platform-for-exploring-unintended-drug-action
#15
Min Oh, Jaegyoon Ahn, Taekeon Lee, Giup Jang, Chihyun Park, Youngmi Yoon
BACKGROUND: The dominant paradigm in understanding drug action focuses on the intended therapeutic effects and frequent adverse reactions. However, this approach may limit opportunities to grasp unintended drug actions, which can open up channels to repurpose existing drugs and identify rare adverse drug reactions. Advances in systems biology can be exploited to comprehensively understand pharmacodynamic actions, although proper frameworks to represent drug actions are still lacking. RESULTS: We suggest a novel platform to construct a drug-specific pathway in which a molecular-level mechanism of action is formulated based on pharmacologic, pharmacogenomic, transcriptomic, and phenotypic data related to drug response ( http://databio...
February 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28135901/voyage-of-theranostic-liposomes-for-imaging-and-therapy
#16
Mitkare Sachin, Dolare Sachin, Sakarkar Dinesh
Drug delivery is a critical issue in any disease treatment. Nowadays much more effort is being focused on integrating imaging agent and therapeutic drugs in a single formulation to achieve a simultaneous disease diagnosis and targeted drug delivery. This new terminology 'nanotheranostics' have been used to describe these nanoparticle formulations. In the ancient years, various nanocarriers (liposomes, nanoparticles, dendrimers, micelles, antibodies, etc.) have been studied for targeted delivery of chemical or biological molecules...
August 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28135081/bacterial-diversity-in-ships-ballast-water-ballast-water-exchange-and-implications-for-ship-mediated-dispersal-of-microorganisms
#17
Despoina S Lymperopoulou, Fred C Dobbs
Using next-generation DNA sequencing of the 16S rRNA gene, we analyzed the composition and diversity of bacterial assemblages in ballast water from tanks of 17 commercial ships arriving to Hampton Roads, Virginia (USA) following voyages in the North Atlantic Ocean. Amplicon sequencing analysis showed the heterogeneous assemblages were (1) dominated by Alpha- and Gammaproteobacteria, Bacteroidetes, and unclassified Bacteria; (2) temporally distinct (June vs August/September); and (3) highly fidelitous among replicate samples...
February 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28096413/modeling-the-role-of-voyaging-in-the-coastal-spread-of-the-early-neolithic-in-the-west-mediterranean
#18
Neus Isern, João Zilhão, Joaquim Fort, Albert J Ammerman
The earliest dates for the West Mediterranean Neolithic indicate that it expanded across 2,500 km in about 300 y. Such a fast spread is held to be mainly due to a demic process driven by dispersal along coastal routes. Here, we model the Neolithic spread in the region by focusing on the role of voyaging to understand better the core elements that produced the observed pattern of dates. We also explore the effect of cultural interaction with Mesolithic populations living along the coast. The simulation study shows that (i) sea travel is required to obtain reasonable predictions, with a minimum sea-travel range of 300 km per generation; (ii) leapfrog coastal dispersals yield the best results (quantitatively and qualitatively); and (iii) interaction with Mesolithic people can assist the spread, but long-range voyaging is still needed to explain the archaeological pattern...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28057361/efficacy-and-safety-of-guselkumab-an-anti-interleukin-23-monoclonal-antibody-compared-with-adalimumab-for-the-treatment-of-patients-with-moderate-to-severe-psoriasis-with-randomized-withdrawal-and-retreatment-results-from-the-phase-iii-double-blind-placebo
#19
RANDOMIZED CONTROLLED TRIAL
Kristian Reich, April W Armstrong, Peter Foley, Michael Song, Yasmine Wasfi, Bruce Randazzo, Shu Li, Y-K Shen, Kenneth B Gordon
BACKGROUND: Phase II data suggested that guselkumab, an anti-interleukin-23 monoclonal antibody, was efficacious in psoriasis. OBJECTIVE: We sought to assess efficacy and safety of guselkumab in moderate to severe psoriasis versus placebo and adalimumab, including interrupted treatment and switching adalimumab nonresponders to guselkumab. METHODS: Patients were randomized to guselkumab 100 mg (weeks 0 and 4, then every 8 weeks; n = 496); placebo→guselkumab (weeks 0, 4, and 12 then guselkumab at weeks 16 and 20; n = 248); or adalimumab (80 mg week 0, then 40 mg week 1, and every 2 weeks through week 23; n = 248)...
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28057360/efficacy-and-safety-of-guselkumab-an-anti-interleukin-23-monoclonal-antibody-compared-with-adalimumab-for-the-continuous-treatment-of-patients-with-moderate-to-severe-psoriasis-results-from-the-phase-iii-double-blinded-placebo-and-active-comparator-controlled
#20
RANDOMIZED CONTROLLED TRIAL
Andrew Blauvelt, Kim A Papp, Christopher E M Griffiths, Bruce Randazzo, Yasmine Wasfi, Yaung-Kaung Shen, Shu Li, Alexa B Kimball
BACKGROUND: Guselkumab, an interleukin-23 blocker, was superior to adalimumab in treating moderate to severe psoriasis in a phase II trial. OBJECTIVES: We sought to compare efficacy and safety of guselkumab with adalimumab and placebo in patients with psoriasis treated for 1 year. METHODS: Patients were randomized to guselkumab 100 mg (weeks 0 and 4, then every 8 weeks; n = 329); placebo→guselkumab (weeks 0, 4, and 12 then guselkumab at weeks 16 and 20, then every 8 weeks; n = 174); or adalimumab (80 mg week 0, 40 mg week 1, then 40 mg every 2 weeks through week 47; n = 334)...
March 2017: Journal of the American Academy of Dermatology
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