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https://www.readbyqxmd.com/read/28135901/voyage-of-theranostic-liposomes-for-imaging-and-therapy
#1
Mitkare Sachin, Dolare Sachin, Sakarkar Dinesh
Drug delivery is a critical issue in any disease treatment. Now-a-days much more effort is being focused on integrating imaging agent and therapeutic drugs in a single formulation to achieve a simultaneous disease diagnosis and targeted drug delivery. This new terminology 'nanotheranostics' have been used to describe these nanoparticle formulations. In past few years, number of nanocarriers (liposomes, nanoparticles, dendrimers, micelles, antibodies etc.) has been studied for targeted delivery of chemical or biological molecules...
January 31, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28135081/bacterial-diversity-in-ships-ballast-water-ballast-water-exchange-and-implications-for-ship-mediated-dispersal-of-microorganisms
#2
Despoina S Lymperopoulou, Fred C Dobbs
Using next-generation DNA sequencing of the 16S rRNA gene, we analyzed the composition and diversity of bacterial assemblages in ballast water from tanks of 17 commercial ships arriving to Hampton Roads, Virginia (USA) following voyages in the North Atlantic Ocean. Amplicon sequencing analysis showed the heterogeneous assemblages were (1) dominated by Alpha- and Gammaproteobacteria, Bacteroidetes, and unclassified Bacteria; (2) temporally distinct (June vs August/September); and (3) highly fidelitous among replicate samples...
February 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28096413/modeling-the-role-of-voyaging-in-the-coastal-spread-of-the-early-neolithic-in-the-west-mediterranean
#3
Neus Isern, João Zilhão, Joaquim Fort, Albert J Ammerman
The earliest dates for the West Mediterranean Neolithic indicate that it expanded across 2,500 km in about 300 y. Such a fast spread is held to be mainly due to a demic process driven by dispersal along coastal routes. Here, we model the Neolithic spread in the region by focusing on the role of voyaging to understand better the core elements that produced the observed pattern of dates. We also explore the effect of cultural interaction with Mesolithic populations living along the coast. The simulation study shows that (i) sea travel is required to obtain reasonable predictions, with a minimum sea-travel range of 300 km per generation; (ii) leapfrog coastal dispersals yield the best results (quantitatively and qualitatively); and (iii) interaction with Mesolithic people can assist the spread, but long-range voyaging is still needed to explain the archaeological pattern...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28057361/efficacy-and-safety-of-guselkumab-an-anti-interleukin-23-monoclonal-antibody-compared-with-adalimumab-for-the-treatment-of-patients-with-moderate-to-severe-psoriasis-with-randomized-withdrawal-and-retreatment-results-from-the-phase-iii-double-blind-placebo
#4
Kristian Reich, April W Armstrong, Peter Foley, Michael Song, Yasmine Wasfi, Bruce Randazzo, Shu Li, Y-K Shen, Kenneth B Gordon
BACKGROUND: Phase II data suggested that guselkumab, an anti-interleukin-23 monoclonal antibody, was efficacious in psoriasis. OBJECTIVE: We sought to assess efficacy and safety of guselkumab in moderate to severe psoriasis versus placebo and adalimumab, including interrupted treatment and switching adalimumab nonresponders to guselkumab. METHODS: Patients were randomized to guselkumab 100 mg (weeks 0 and 4, then every 8 weeks; n = 496); placebo→guselkumab (weeks 0, 4, and 12 then guselkumab at weeks 16 and 20; n = 248); or adalimumab (80 mg week 0, then 40 mg week 1, and every 2 weeks through week 23; n = 248)...
December 29, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28057360/efficacy-and-safety-of-guselkumab-an-anti-interleukin-23-monoclonal-antibody-compared-with-adalimumab-for-the-continuous-treatment-of-patients-with-moderate-to-severe-psoriasis-results-from-the-phase-iii-double-blinded-placebo-and-active-comparator-controlled
#5
Andrew Blauvelt, Kim A Papp, Christopher E M Griffiths, Bruce Randazzo, Yasmine Wasfi, Yaung-Kaung Shen, Shu Li, Alexa B Kimball
BACKGROUND: Guselkumab, an interleukin-23 blocker, was superior to adalimumab in treating moderate to severe psoriasis in a phase II trial. OBJECTIVES: We sought to compare efficacy and safety of guselkumab with adalimumab and placebo in patients with psoriasis treated for 1 year. METHODS: Patients were randomized to guselkumab 100 mg (weeks 0 and 4, then every 8 weeks; n = 329); placebo→guselkumab (weeks 0, 4, and 12 then guselkumab at weeks 16 and 20, then every 8 weeks; n = 174); or adalimumab (80 mg week 0, 40 mg week 1, then 40 mg every 2 weeks through week 47; n = 334)...
December 29, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27986366/end-tidal-co2-relates-to-seasickness-susceptibility-a-study-in-antarctic-voyages
#6
Tatsuhisa Hasegawa, Hirofumi Oe, Masakatsu Taki, Hirofumi Sakaguchi, Shigeru Hirano, Yoshiro Wada
OBJECTIVE: To investigate the relationship between end-tidal CO2 (EtCO2) and seasickness (motion sickness at sea) during an Antarctic voyage. METHODS: In this study, we measured EtCO2 and severity of seasickness using the subjective symptoms of motion sickness (SSMS). We sampled EtCO2 and SSMS every 3-4h for 3 days from the date of sail in 16 healthy subjects. This experiment was performed on an icebreaker (standard displacement: 12,650t). RESULTS: Since 2 subjects dropped out because of severe motion sickness, available data were collected from 14 subjects...
December 13, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27959631/the-microscope-as-a-tool-for-disease-discovery-a-personal-voyage
#7
Elaine S Jaffe
This review reflects the trajectory of my career in hematopathology, and my personal reflections on scientific advances in the field. During the course of more than 40 years, the approach to classification of hematological malignancies has evolved from descriptive approaches, based on either cytological or clinical features, to a modern approach, which incorporates cutting-edge technologies. My philosophy has focused on defining individual diseases, an approach that can best lead to an understanding of molecular pathogenesis...
January 24, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/27938714/the-welfare-risks-and-impacts-of-heat-stress-on-sheep-shipped-from-australia-to-the-middle-east
#8
REVIEW
Clive Phillips
This review considers the welfare issues confronting sheep due to heat stress on board ships undertaking long distance voyages. Sheep engage in behavioural and physiologic mechanisms to attempt to mitigate heat stress, but the evidence from Australian shipments from 2005 to 2014 is that mortality approximately doubles when sheep are transported from Australia in winter to the Middle East in summer. Much of this increase has been attributed to salmonellosis and inanition, but this may have been mistaken for, or exacerbated by, heat stress...
December 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27927179/voyage-of-discovery-a-comment-on-koch-et-al-a-voyage-to-terra-australis-human-mediated-dispersal-of-cats
#9
Rose L Andrew, Deane Smith, Jamieson C Gorrell, Jasmine K Janes
The origins of feral cats in Australia may be understood with the help of molecular studies, but it is important that hypotheses be tested with appropriate sampling and methodology. We point out several shortcomings in the analysis by Koch et al. (BMC Evol Biol 15:262, 2015; A voyage to Terra Australis: human-mediated dispersal of cats. Dryad Digital Repository, 2015), present a reanalysis of part of the study and discuss the challenges of elucidating the early history of feral cats.
December 7, 2016: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/27855252/-cardiovascular-risk-among-spanish-seafarers
#10
Mª Del Carmen Romero Paredes, Luis Reinoso Barbero, Mª Fernanda González Gomez, Ana Capapé Aguilar, Fernando Bandrés Moya
OBJECTIVE: Working at sea makes it difficult to receive proper medical attention. Moreover, the prognosis of an acute cardiovascular event often depends on the measures taken in the first few hours after the onset of symptoms, but are often delayed in seamen. Thus, it is very important to detect cardiovascular risk factors in these workers as early as possible. The aim of this study was to measure the prevalence of cardiovascular risk factors among sailors. METHODS: Data were on a sample of 334 individuals in the Madrid Maritime Health Service in 2011...
October 2016: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/27853601/origin-and-timing-of-new-zealand-s-earliest-domestic-chickens-polynesian-commensals-or-european-introductions
#11
Jamie R Wood, Michael J B Herrera, R Paul Scofield, Janet M Wilmshurst
Human settlers transported chickens (Gallus gallus domesticus) to most East Polynesian archipelagos between AD 1000 and 1300; however, it has long been assumed that New Zealand was an exception. Despite the fact that chicken bones have been recovered from localities of early archaeological middens in New Zealand, their age and genetic relationships have never been critically assessed. Here, we test the assumption that chickens were not introduced to New Zealand during prehistory through ancient DNA and radiocarbon analyses of chicken bones from sites of Māori middens containing prehistoric material...
August 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27835854/environmental-status-and-early-warning-value-of-the-pollutant-semicarbazide-in-jincheng-and-sishili-bays-shandong-peninsula-china
#12
Xiuhui Tian, Yingjiang Xu, Xianghong Gong, Dianfeng Han, Zhongquan Wang, Quanli Zhou, Chunxiao Sun, Chuanbo Ren, Jinglin Xue, Chuanhai Xia
A verified method for measuring Semicarbazide (SEM) in seawater, sediments, and shellfish was developed based on ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). A total of 30 stations were radially distributed in Jincheng and Sishili Bays in the Bohai and Yellow Seas, and 1025 monitoring data were collected in 41 voyages, 615 seawater samples, 320 sediment samples and 90 shellfish samples. The concentration ranged from 0.011μg/L to 0.093μg/L and 0 to 0.75μg/kg in seawater and shellfish respectively, but SEM in sediment was all below the limit of detection...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27811805/enigmas-from-the-past-m-intosh-s-1885-annelidicolous-copepods%C3%A2-from-the-voyage-of-h-m-s-challenger
#13
Rony Huys
The type material of four monotypic genera, Leaniricola, Oestrella, Praxillinicola and Trophoniphila (Copepoda, Cyclopoida), described by M'Intosh (1885) from deep water polychaete hosts collected during the H.M.S. Challenger expedition, is re-examined. Leaniricola rotundata M'Intosh (1885) is removed from its floating status as species inquirenda in the Nereicolidae and fixed as the type of a new family, Leaniricolidae fam. nov., based on the presence of an oral cone and massive, three-dimensionally expanded, mandibular gnathobases which are used to anchor the parasite in the parapodial integument of its host...
October 11, 2016: Zootaxa
https://www.readbyqxmd.com/read/27807258/-pace-gate-when-clinical-trial-evidence-meets-open-data-access
#14
EDITORIAL
Keith J Geraghty
Science is not always plain sailing and sometimes the voyage is across an angry sea. A recent clinical trial of treatments for chronic fatigue syndrome (the PACE trial) has whipped up a storm of controversy. Patients claim the lead authors overstated the effectiveness of cognitive behavioural therapy and graded exercise therapy by lowering the thresholds they used to determine improvement. In this extraordinary case, patients discovered that the treatments tested had much lower efficacy after an information tribunal ordered the release of data from the PACE trial to a patient who had requested access using a freedom of information request...
November 1, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27791145/using-seafaring-simulations-and-shortest-hop-trajectories-to-model-the-prehistoric-colonization-of-remote-oceania
#15
Álvaro Montenegro, Richard T Callaghan, Scott M Fitzpatrick
The prehistoric colonization of islands in Remote Oceania that began ∼3400 B.P. represents what was arguably the most expansive and ambitious maritime dispersal of humans across any of the world's seas or oceans. Though archaeological evidence has provided a relatively clear picture of when many of the major island groups were colonized, there is still considerable debate as to where these settlers originated from and their strategies/trajectories used to reach habitable land that other datasets (genetic, linguistic) are also still trying to resolve...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27790956/biological-voyage-of-solid-lipid-nanoparticles-a-proficient-carrier-in-nanomedicine
#16
Hasan Ali, Sandeep Kumar Singh
This review projects the prospects and issues faced by solid lipid nanoparticles (SLNs) in current scenarios, specially related to its clinical implementation and effectiveness. We re-examine the basic concept of biobehavior and movement of SLNs as a nanomedicine carrier. The extensive survey of the uptake and absorption mechanism from different routes, distribution pattern, targeting efficiency, effect of surface functionalization on biodistribution, elimination pathways and toxic effects have been documented...
October 2016: Therapeutic Delivery
https://www.readbyqxmd.com/read/27766474/ischaemic-conditioning-and-targeting-reperfusion-injury-a-30%C3%A2-year-voyage-of-discovery
#17
REVIEW
Derek J Hausenloy, Jose A Barrabes, Hans Erik Bøtker, Sean M Davidson, Fabio Di Lisa, James Downey, Thomas Engstrom, Péter Ferdinandy, Hector A Carbrera-Fuentes, Gerd Heusch, Borja Ibanez, Efstathios K Iliodromitis, Javier Inserte, Robert Jennings, Neena Kalia, Rajesh Kharbanda, Sandrine Lecour, Michael Marber, Tetsuji Miura, Michel Ovize, Miguel A Perez-Pinzon, Hans Michael Piper, Karin Przyklenk, Michael Rahbek Schmidt, Andrew Redington, Marisol Ruiz-Meana, Gemma Vilahur, Jakob Vinten-Johansen, Derek M Yellon, David Garcia-Dorado
To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the history of IPC, its evolution to IPost and RIC, myocardial reperfusion injury as a therapeutic target, and future targets and strategies for cardioprotection. This article provides an overview of the major topics discussed at this special meeting and underscores the huge importance and impact, the discovery of IPC has made in the field of cardiovascular research...
November 2016: Basic Research in Cardiology
https://www.readbyqxmd.com/read/27681216/head-injury-in-a-cruise-passenger-during-a-shore-excursion
#18
Eilif Dahl
A 66-year-old overweight insulin-dependent male passenger with diabetes and severe arthritis was on a 4-week circle-Pacific cruise. He fell ashore and hit his head. The ship was about to leave on a non-stop voyage - without any evacuation possibilities for the next 8 days. He was examined and had X-rays taken at the local hospital, but as his head injury was considered mild, he returned to the ship "for 48 hours of observation for signs of intracranial bleeding" - against the ship's doctor's advice. Delayed suspicion of a non-displaced cervical fracture caused extra work and worries and could have, but did not complicate matters...
2016: International Maritime Health
https://www.readbyqxmd.com/read/27681215/head-injury-and-anisocoria-on-a-cruise-ship
#19
Eilif Dahl
A previously healthy 65-year-old female passenger presented on the 3rd day of her voyage with a small facial laceration after she fell and hit her forehead, following sudden blurred vision and dizziness. When the ship's doctor noticed that one pupil was much bigger than the other, he feared intracranial bleeding and considered helicopter evacuation. Her symptoms had started shortly after she had removed a transdermal scopolamine patch from behind her ear. Getting scopolamine from her hands in direct contact with the eye surface caused mydriasis...
2016: International Maritime Health
https://www.readbyqxmd.com/read/27679628/increasing-resilience-in-adolescents-the-importance-of-social-connectedness-in-adventure-education-programmes
#20
Damian Scarf, Jillian G Hayhurst, Benjamin C Riordan, Mike Boyes, Ted Ruffman, John A Hunter
OBJECTIVE: Mental health problems are a leading cause of health-related disability during adolescence. The objectives of the current study were to investigate whether participating in an adventure education programme (AEP) increased adolescents' resilience and elucidate how social connectedness contributes to any increase. METHOD: Adolescents who participated in the AEP had their resilience measured on the first (Time 1) and last day (Time 2) of a 10-day voyage...
September 27, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
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