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https://www.readbyqxmd.com/read/29602889/adult-scurvy-associated-with-psychiatric-disorders-and-breast-feeding
#1
Stefania Urueña-Palacio, Bruno L Ferreyro, Lucas G Fernández-Otero, Pablo D Calo
Scurvy is a nutritional disease caused by ascorbic acid deficiency and is potentially fatal. It was originally described in the 18th century by James Lind and associated with long sea voyages and insufficient citrus consumption. Its prevalence has declined markedly over the years but has still been described sporadically in certain countries. A 22-year-old woman with an anxiety disorder and anorexia nervosa, recent pregnancy and ongoing breast feeding, presented with a 10-day history of spontaneous haematomas in the lower limbs, gingivorrhagia and fatigue...
March 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29566413/rivaroxaban-a-new-treatment-paradigm-in-the-setting-of-vascular-protection
#2
Rupert Bauersachs, Faiez Zannad
The pathophysiology of atherosclerosis involves a diseased endothelium, lipid accumulation and low-grade inflammation. In later stages of coronary artery disease (CAD) and peripheral arterial disease (PAD), plaque rupture may induce atherothrombosis caused by fibrin formation and platelet activation, leading to vessel occlusion with subsequent organ damage such as myocardial infarction, stroke or limb ischaemia. Because of the high disease burden associated with CAD and PAD, there is a need for continuous vascular protection beyond currently available treatments including antiplatelet agents...
March 22, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29562538/the-20-year-voyage-aboard-the-journal-of-alzheimer-s-disease-docking-at-type-3-diabetes-environmental-exposure-factors-pathogenic-mechanisms-and-potential-treatments
#3
Suzanne M de la Monte, Ming Tong, Jack R Wands
The Journal of Alzheimer's Disease (JAD), founded in 1998, played a pivotal role in broadening the field of research on Alzheimer's disease (AD) by publishing a diverse range of clinical, pathological, molecular, biochemical, epidemiological, experimental, and review articles from its birth. This article recounts my own journey as an author who contributed articles to JAD over the 20 years of the journal's existence. In retrospect, it seems remarkable that a considerable body of work that originated from our group marks a trail that began with studies of vascular, stress, and mitochondrial factors in AD pathogenesis, exploded into the concept of 'Type 3 Diabetes', and continued with the characterization of how environmental, exposure, and lifestyle factors promote neurodegeneration and which therapeutic strategies could reverse the neurodegeneration cascade...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29527011/space-flight-associated-neuro-ocular-syndrome-sans
#4
REVIEW
Andrew G Lee, Thomas H Mader, C Robert Gibson, Tyson J Brunstetter, William J Tarver
Interesting novel and somewhat perplexing physiologic and pathologic neuro-ocular findings have been documented in astronauts during and after long duration space flight (LDSF). These findings collectively have been termed the "space flight-associated neuro-ocular syndrome" (SANS). The National Aeronautics and Space Administration (NASA) in the United States has meticulously and prospectively documented the clinical, ultrasound, optical coherence tomography imaging, and radiographic findings of SANS including unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts (i...
March 12, 2018: Eye
https://www.readbyqxmd.com/read/29523545/microbiome-dynamics-in-a-large-artificial-seawater-aquarium
#5
Nastassia V Patin, Zoe A Pratte, Matthew Regensburger, Eric Hall, Kailen Gilde, Alistair D M Dove, Frank J Stewart
Artificial habitats for animals have high commercial and societal value. Microbial communities (microbiomes) in such habitats may play ecological roles similar to those in nature. However, this hypothesis remains largely untested. Georgia Aquarium's Ocean Voyager (OV) exhibit is a closed-system aquatic habitat that mimics the oligotrophic open ocean and houses thousands of large marine animals, including fish, sea turtles, and whale sharks. We present a 14-month time series characterizing the OV water column microbiome...
March 9, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29516116/tilling-the-next-generation
#6
Bradley J Till, Sneha Datta, Joanna Jankowicz-Cieslak
Gene space: the final frontier in plant functional genomics. These are the voyages of TILLING, the reverse-genetics strategy that sought to boldly go where no-one had gone before by combining high-density chemical mutagenesis with high-throughput mutation discovery. Its 18-year mission has been to explore new technologies such as next generation sequencing and to seek out new strategies like in silico databases of catalogued EMS-induced mutations from entire mutant plant populations. This chapter is a clip show highlighting key milestones in the development of TILLING...
March 8, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29512196/patient-reported-symptoms-and-signs-of-moderate-to-severe-psoriasis-treated-with-guselkumab-or-adalimumab-results-from-the-randomized-voyage-1-trial
#7
K A Papp, A Blauvelt, A B Kimball, C Han, B Randazzo, Y Wasfi, Y-K Shen, S Li, C E M Griffiths
BACKGROUND: How patients experience the symptoms/signs of psoriasis is highly relevant for assessing treatment response. OBJECTIVES: Compare outcomes with guselkumab, placebo, and adalimumab utilizing the novel, validated Psoriasis Symptoms and Signs Diary (PSSD). METHODS: VOYAGE 1 is an on-going, phase III, double-blinded, controlled trial of patients with moderate-to-severe psoriasis. Patients were randomized to guselkumab 100 mg every-8-weeks; placebo-to-guselkumab 100 mg every-8-weeks; or adalimumab 40 mg every-2-weeks...
March 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29466652/gal%C3%A3-pagos-macroalgae-a-review-of-the-state-of-ecological-knowledge
#8
Paul Tompkins, Matthias Wolff
Previous work has highlighted the critical role of macroalgal productivity and dynamics in supporting and structuring marine food webs. Spatio-temporal variability in macroalgae can alter coastal ecosystems, a relationship particularly visible along upwelling-influenced coastlines. As a result of its equatorial location and nutrient rich, upwelling-influenced waters, the Galápagos Archipelago in the East Pacific, hosts a productive and biodiverse marine ecosystem. Reports and collections of macroalgae date back to the Beagle voyage, and since then, more than three hundred species have been reported...
March 2017: Revista de Biología Tropical
https://www.readbyqxmd.com/read/29461516/a-database-of-chlorophyll-a-in-australian-waters
#9
Claire H Davies, Penelope Ajani, Linda Armbrecht, Natalia Atkins, Mark E Baird, Jason Beard, Pru Bonham, Michele Burford, Lesley Clementson, Peter Coad, Christine Crawford, Jocelyn Dela-Cruz, Martina A Doblin, Steven Edgar, Ruth Eriksen, Jason D Everett, Miles Furnas, Daniel P Harrison, Christel Hassler, Natasha Henschke, Xavier Hoenner, Tim Ingleton, Ian Jameson, John Keesing, Sophie C Leterme, M James McLaughlin, Margaret Miller, David Moffatt, Andrew Moss, Sasi Nayar, Nicole L Patten, Renee Patten, Sarah A Pausina, Roger Proctor, Eric Raes, Malcolm Robb, Peter Rothlisberg, Emily A Saeck, Peter Scanes, Iain M Suthers, Kerrie M Swadling, Samantha Talbot, Peter Thompson, Paul G Thomson, Julian Uribe-Palomino, Paul van Ruth, Anya M Waite, Simon Wright, Anthony J Richardson
Chlorophyll a is the most commonly used indicator of phytoplankton biomass in the marine environment. It is relatively simple and cost effective to measure when compared to phytoplankton abundance and is thus routinely included in many surveys. Here we collate 173, 333 records of chlorophyll a collected since 1965 from Australian waters gathered from researchers on regular coastal monitoring surveys and ocean voyages into a single repository. This dataset includes the chlorophyll a values as measured from samples analysed using spectrophotometry, fluorometry and high performance liquid chromatography (HPLC)...
February 20, 2018: Scientific Data
https://www.readbyqxmd.com/read/29459843/hypothesis-the-vestibular-and-cerebellar-basis-of-the-mal-de-debarquement-syndrome
#10
Bernard Cohen, Sergei B Yakushin, Catherine Cho
The Mal de Debarquement syndrome (MdDS) generally follows sea voyages, but it can occur after turbulent flights or spontaneously. The primary features are objective or perceived continuous rocking, swaying, and/or bobbing at 0.2 Hz after sea voyages or 0.3 Hz after flights. The oscillations can continue for months or years and are immensely disturbing. Associated symptoms appear to be secondary to the incessant sensation of movement. We previously suggested that the illness can be attributed to maladaptation of the velocity storage integrator in the vestibular system, but the actual neural mechanisms driving the MdDS are unknown...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29416906/space-brain-the-negative-effects-of-space-exposure-on-the-central-nervous-system
#11
REVIEW
Rahul Jandial, Reid Hoshide, J Dawn Waters, Charles L Limoli
Journey to Mars will be a large milestone for all humankind. Throughout history, we have learned lessons about the health dangers associated with exploratory voyages to expand our frontiers. Travelling through deep space, the final frontier, is planned for the 2030s by NASA. The lessons learned from the adverse health effects of space exposure have been encountered from previous, less-lengthy missions. Prolonged multiyear deep space travel to Mars could be encumbered by significant adverse health effects, which could critically affect the safety of the mission and its voyagers...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29373853/tiny-conveyance-micro-and-nanorobots-prepare-to-advance-medicine
#12
Leslie Mertz
In the science-fiction classic Fantastic Voyage [1], a shrink-ray zaps a submarine and the crew within it, and the resulting microscopic vehicle ventures inside a human body to destroy a blood clot and save a prominent patient's life. While that scenario remains in the realm of make-believe, it may not be long before micro- and nanoscale robots can navigate a person's blood vessels and execute a medical task, such as the targeted delivery of drugs or even the performance of some medical procedures.
January 2018: IEEE Pulse
https://www.readbyqxmd.com/read/29352870/radiation-grafting-a-voyage-from-bio-waste-corn-husk-to-an-efficient-thermostable-adsorbent
#13
Jhimli Paul Guin, Y K Bhardwaj, Lalit Varshney
The initiator free environmentally benign gamma radiation is employed to graft poly-acrylic acid (PAA) onto the widely produced bio-waste corn husk to develop promising, cheap, efficient and reusable adsorbent (AAc-g-husk) having specific adsorption capacity of 1682.7mgg-1 of methylene blue (MB) at pH 9.0 and 320K. The most suitable grafting yield is found by optimizing absorbed dose, dose rate and concentrations of monomer, Mohr's salt and inorganic acid. The inter-planar hydrogen bonding among (002) planes of cellulose in the husk decreases after diversifying grafting of PAA on ad-axial, ribs and micro-fibrils surfaces of the corn husks...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29302165/dedicated-caravan-sites-for-french-gens-du-voyage-public-health-policy-or-construction-of-health-and-environmental-inequalities
#14
Lise Foisneau
In France, gens du voyage ("people who travel" or "travellers") is a term used by the government to categorize various itinerant populations, the majority of which are diverse Romani groups. People categorized as gens du voyage are legally required to reside in particular locations called "dedicated caravan sites." Parliamentary debates about these dedicated caravan sites have clarified that one of the objectives of such sites is to help fulfill the gens du voyage 's right to health...
December 2017: Health and Human Rights
https://www.readbyqxmd.com/read/29299801/zooplankton-impact-on-the-organic-matter-flux-of-siberian-arctic-seas
#15
A F Pasternak, A V Drits, M D Kravchishina, M V Flint
Role of zooplankton in the organic matter flux was studied in the Kara and Laptev seas using sediment traps in the course of voyage 63 of the Academician Mstislav Keldysh research vessel in August-October 2015. The values of the total flux and that of organic matter were at least an order of magnitude higher than those obtained before the 2000s. A hypothesis is proposed on an increasing influence of the river runoff on the Kara Sea area under climatic changes. Zooplankton contribution into Corg flux varied broadly, averaging 50%...
November 2017: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/29277452/a-three-year-study-of-metal-levels-in-skin-biopsies-of-whales-in-the-gulf-of-mexico-after-the-deepwater-horizon-oil-crisis
#16
John Pierce Wise, James T F Wise, Catherine F Wise, Sandra S Wise, Christy Gianios, Hong Xie, Ron Walter, Mikki Boswell, Cairong Zhu, Tongzhang Zheng, Christopher Perkins, John Pierce Wise
In response to the explosion of the Deepwater Horizon and the massive release of oil that followed, we conducted three annual research voyages to investigate how the oil spill would impact the marine offshore environment. Most investigations into the ecological and toxicological impacts of the Deepwater Horizon Oil crisis have mainly focused on the fate of the oil and dispersants, but few have considered the release of metals into the environment. From studies of previous oil spills, other marine oil industries, and analyses of oil compositions, it is evident that metals are frequently encountered...
February 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29250112/early-human-migrations-ca-13-000-years-ago-or-postcontact-europeans-for-the-earliest-spread-of-mycobacterium-leprae-and-mycobacterium-lepromatosis-to-the-americas
#17
REVIEW
Samuel Mark
For over a century, it has been widely accepted that leprosy did not exist in the Americas before the arrival of Europeans. This proposition was based on a combination of historical, paleopathological, and representational studies. Further support came from molecular studies in 2005 and 2009 that four Mycobacterium leprae single-nucleotide polymorphisms (SNPs) and then 16 SNP subtypes correlated with general geographic regions, suggesting the M. leprae subtypes in the Americas were consistent with European strains...
2017: Interdisciplinary Perspectives on Infectious Diseases
https://www.readbyqxmd.com/read/29219633/brain-activity-during-phonation-in-healthy-female-singers-with-supraglottic-compression-an-fmri-pilot-study
#18
Maryna Kryshtopava, Kristiane Van Lierde, Charlotte Defrancq, Michiel De Moor, Zoë Thijs, Evelien D'Haeseleer, Iris Meerschman, Pieter Vandemaele, Guy Vingerhoets, Sofie Claeys
This pilot study evaluated the usability of functional magnetic resonance imaging (fMRI) to detect brain activation during phonation in healthy female singers with supraglottic compression. Four healthy female classical singers (mean age: 26 years) participated in the study. All subjects had normal vocal folds and vocal characteristics and showed supraglottic compression. The fMRI experiment was carried out using a block design paradigm. Brain activation during phonation and exhalation was analyzed using Brain Voyager software (Brain Innovation B...
December 8, 2017: Logopedics, Phoniatrics, Vocology
https://www.readbyqxmd.com/read/29191891/bone-voyage-osteoblasts-remotely-control-tumors
#19
COMMENT
Haiying Zhang, David Lyden
No abstract text is available yet for this article.
December 1, 2017: Science
https://www.readbyqxmd.com/read/29180516/the-egfr-odyssey-from-activation-to-destruction-in-space-and-time
#20
REVIEW
Jeroen Bakker, Menno Spits, Jacques Neefjes, Ilana Berlin
When cell surface receptors engage their cognate ligands in the extracellular space, they become competent to transmit potent signals to the inside of the cell, thereby instigating growth, differentiation, motility and many other processes. In order to control these signals, activated receptors are endocytosed and thoroughly curated by the endosomal network of intracellular vesicles and proteolytic organelles. In this Review, we follow the epidermal growth factor (EGF) receptor (EGFR) from ligand engagement, through its voyage on endosomes and, ultimately, to its destruction in the lysosome...
December 15, 2017: Journal of Cell Science
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