keyword
MENU ▼
Read by QxMD icon Read
search

Cutaneous squamous cell carcinoma

keyword
https://www.readbyqxmd.com/read/29452120/quantifying-the-polygenic-contribution-to-cutaneous-squamous-cell-carcinoma-risk
#1
Joanne E Sordillo, Peter Kraft, Ann Chen Wu, Maryam M Asgari
Genetic factors play an important role in cutaneous squamous cell carcinoma (cSCC) risk. Genome-wide association studies have identified 21 single nucleotide polymorphisms (SNPs) associated with cSCC risk. Yet no studies have attempted to quantify the contribution of heritability to cSCC risk by calculating the population attributable risk (PAR) using a combination of all discovered genetic variants. Using an additive multi-locus linear logistic model, we determined the cumulative association of these 21 genetic regions to cSCC PAR...
February 13, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29448853/risk-factors-for-positive-margins-after-wide-local-excision-of-cutaneous-squamous-cell-carcinoma
#2
Thomas Jonathan Stewart, Alan Saunders
BACKGROUND AND OBJECTIVES: The standard treatment for cutaneous squamous cell carcinoma (cSCC) is wide local excision (WLE). Incomplete tumor excision is associated with increased recurrence rates and mortality risk. Risk factors for positive margins after WLE of cSCC has been examined in only a few studies. We sought to assess the influence of several clinicopathological factors on margin status in the largest cSCC population to date. METHODS: We performed a retrospective review of records at two skin cancer clinics identifying patients with biopsy-proven cSCC who underwent WLE...
February 16, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29447642/is-it-just-a-psoriasiform-dermatitis
#3
Olalla Figueroa-Silva, Martina Espasandín-Arias, Francisco Javier García-Martínez, Virginia Fernández-Redondo, Jaime Toribio
Bazex syndrome (BS) is a rare paraneoplastic syndrome most frequently associated with squamous cell carcinomas of the upper aerodigestive tractand other tumours. Characteristically, cutaneous lesions precede the diagnosis of malignancy. We report a 72-year-old patient with 1-year history of acral dermatitis. The diagnosis of BS was based on the presence of psoriasiform acral dermatitis and the evidence of two simultaneous tumors (prostate adenocarcinoma and undifferentiated carcinoma ofthe submandibular gland)...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29447639/a-patient-case-highlighting-the-myriad-of-cutaneous-adverse-effects-of-prolonged-use-of-hydroxyurea
#4
Brett Neill, Ted Ryser, John Neill, Daniel Aires, Anand Rajpara
BACKGROUND: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer. CASE PRESENTATION: We report a 67-year-oldman with a history of polycythemia vera who was referred for management of progressively worsening dorsal hand lesions. The patient presented withhyperpigmentation, ichthyosis, plantar keratoderma, dermatomyositis-like eruptions, two squamous cell carcinomas, and actinic keratoses...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29437807/lymphangitis-carcinomatosa-of-a-cutaneous-squamous-cell-carcinoma
#5
Marloes Sophia van Kester, Roel Erik Genders, Koen Dirk Quint
No abstract text is available yet for this article.
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29437678/multidisciplinary-surgical-team-approach-for-excision-of-squamous-cell-carcinoma-overlying-pacemaker-site
#6
Neil Bodagh, Elena Pappa, Fahad Farooqi
We report an unusual case of an elderly man presenting with a fast-growing large malignant tumour involving the skin overlying his permanent pacemaker site. The fast-growing cutaneous squamous cell carcinoma appeared 2 years after pacemaker implantation. Joint specialist input was required to tackle this complex problem as a wide surgical excision would expose the pacemaker generator risking device infection particularly if the skin graft reconstruction failed. Having established that the patient had minimal pacing needs, it was determined through expedited multidisciplinary discussion that the best option was excision of the lesion with skin grafting of the defect by maxillofacial surgical team and pacemaker generator removal by a cardiologist in a joint surgical procedure...
February 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29436004/homeobox-transcriptional-factor-engrailed-homeobox-1-is-specifically-expressed-in-normal-and-neoplastic-sweat-gland-cells
#7
Keiko Miura, Takumi Akashi, Noboru Ando, Shinya Ayabe, Kou Kayamori, Takeshi Namiki, Yoshinobu Eishi
AIM: A number of homeobox transcriptional factors are utilized as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is specifically expressed in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms. METHODS AND RESULTS: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be specifically expressed in the skin...
February 12, 2018: Histopathology
https://www.readbyqxmd.com/read/29428356/classification-of-the-clinical-images-for-benign-and-malignant-cutaneous-tumors-using-a-deep-learning-algorithm
#8
Seung Seog Han, Myoung Shin Kim, Woohyung Lim, Gyeong Hun Park, Ilwoo Park, Sung Eun Chang
We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevus, lentigo, pyogenic granuloma, hemangioma, dermatofibroma, and wart. The convolutional neural network (Microsoft ResNet-152 model) was fine-tuned with images from the training portion of the Asan dataset, MED-NODE dataset, and atlas site images (20,826 images in total)...
February 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29427464/the-expression-and-function-of-galectins-in-skin-physiology-and-pathology
#9
REVIEW
Nan-Lin Wu, Fu-Tong Liu
The galectin family comprises β-galactoside-binding proteins widely expressed in many organisms. There are at least 16 family members, which can be classified into three groups based on their carbohydrate-recognition domains. Pleiotropic functions of different galectins in physiological and pathological processes through extracellular or intracellular actions have been revealed. In the skin, galectins are expressed in a variety of cells, including keratinocytes, melanocytes, fibroblasts, dendritic cells, lymphocytes, macrophages, and endothelial cells...
February 10, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29422656/methylation-profiling-identifies-two-subclasses-of-squamous-cell-carcinoma-related-to-distinct-cells-of-origin
#10
Manuel Rodríguez-Paredes, Felix Bormann, Günter Raddatz, Julian Gutekunst, Carlota Lucena-Porcel, Florian Köhler, Elisabeth Wurzer, Katrin Schmidt, Stefan Gallinat, Horst Wenck, Joachim Röwert-Huber, Evgeniya Denisova, Lars Feuerbach, Jeongbin Park, Benedikt Brors, Esther Herpel, Ingo Nindl, Thomas G Hofmann, Marc Winnefeld, Frank Lyko
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic keratosis (AK). Despite various efforts to characterize these lesions molecularly, the etiology of AK and its progression to cSCC remain partially understood. Here, we use Infinium MethylationEPIC BeadChips to interrogate the DNA methylation status in healthy, AK and cSCC epidermis samples. Importantly, we show that AK methylation patterns already display classical features of cancer methylomes and are highly similar to cSCC profiles...
February 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29419901/cytokeratin-19-expression-is-a-risk-factor-for-metastasis-in-cutaneous-squamous-cell-carcinoma
#11
J Kato, T Hida, S Sugita, T Hasegawa, S Kamiya, K Horimoto, S Sato, M Sawada, H Uhara
Cytokeratin 19 (CK19) expression has been reported to be a risk factor for metastasis in oral squamous cell carcinoma. However, the significance of CK19 expression in cutaneous squamous cell carcinoma (cSCC) is unclear. Although some studies have reported CK19 expression in cSCC, no study has focused on the relationship between CK19 expression and metastasis in cSCC. Herein, we evaluate whether CK19 expression is related to metastasis in cSCC. This article is protected by copyright. All rights reserved.
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29419888/evaluation-of-t-lymphocyte-subpopulations-in-actinic-keratosis-in-situ-and-invasive-squamous-cell-carcinoma-of-the-skin
#12
Aristea Stravodimou, Vassiliki Tzelepi, Helen Papadaki, Athanasia Mouzaki, Sophia Georgiou, Maria Melachrinou, Eleni P Kourea
BACKGROUND: Tumor infiltrating lymphocytes (TILs) represent important regulators of carcinogenesis. Cutaneous invasive squamous cell carcinoma (inSCC) develops through precursor lesions, namely in situ squamous cell carcinoma (isSCC) and actinic keratosis (AK), representing a natural model of carcinogenesis. The study evaluates TIL subpopulations in inSCC and its precursors by comparing two semi-quantitative scoring systems, and assesses the presence of regulatory T-cells (Tregs) in these lesions...
February 8, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29414185/prevalence-and-stability-of-antibodies-to-thirteen-polyomaviruses-and-association-with-cutaneous-squamous-cell-carcinoma-a-population-based-study
#13
Annika Antonsson, Rachel E Neale, Peter O'Rourke, Leesa Wockner, Angelika Michel, Michael Pawlita, Tim Waterboer, Adèle C Green
BACKGROUND: Several new members of the human polyomavirus (HPyV) family that infect human skin and are potentially oncogenic have been identified in the last decade. OBJECTIVES: To investigate prospectively the seroprevalence and stability of 13 PyVs, and possible associations with different risk factors and cutaneous squamous cell carcinoma (cSCC). STUDY DESIGN: In this Australian population-based longitudinal study sera were collected at baseline in 1992 or during the next 4 years from 688 people...
January 30, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29405246/metastasis-risk-of-cutaneous-squamous-cell-carcinoma-in-organ-transplant-recipients-and-immunocompetent-patients
#14
Roel E Genders, Joris A J Osinga, Elise E Tromp, Peter O'Rourke, Jan N Bouwes Bavinck, Elsemieke I Plasmeijer
Organ transplant recipients (OTRs) have a high incidence of cutaneous squamous cell carcinoma (cSCC), and immunosuppression has been reported to be an important risk factor for metastasis. The aim of this study was to identify the metastasis risk over a 10-year period for 593 patients with cSCC, of whom 134 were OTR and 459 were immunocompetent. Metastasis incidence rate was 1,046 (95% confidence interval (95% CI) 524-2,096) per 100,000 person years in OTR and 656 (95% CI; 388-1,107) in immunocompetent patients, yielding an incidence rate ratio of 1...
February 6, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29400378/the-value-of-ultrasound-diagnosis-in-the-multidisciplinary-approach-of-cutaneous-tumours-case-report
#15
Avram Manea, Diana Crisan, Alexandru Florin Badea, Iuliu Dinu Dumitrascu, Mihaela Felicia Baciut, Simion Bran, Ileana Mitre, Maria Crisan, Grigore Baciut
We report the case of a senior patient, presenting with two cutaneous tumours in which the clinical and dermoscopic examination pointed towards a basal cell carcinoma. Ultrasound revealed highly vascularised tumours and elastography showed increased rigidity. Histological examination of both lesions following complete resection was consistent with squamous cell carcinomas. The distinctive feature of this case consists of the complex non-invasive diagnostic imaging of the tumour morphology, performed in real time, revealing aspects compatible with highly proliferative malignant tumours...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29394319/the-polycomb-proteins-ring1b-and-ezh2-repress-the-tumoral-proinflammatory-function-in-metastasizing-primary-cutaneous-squamous-cell-carcinoma
#16
Eugenia Hernández-Ruiz, Agustí Toll, Irene García-Diez, Evelyn Andrades, Carla Ferrandiz-Pulido, Emili Masferrer, Mireia Yébenes, Ane Jaka, Javier Gimeno, Ramón Gimeno, Vicenç García-Patos, Ramón M Pujol, Inmaculada Hernández-Muñoz
Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy in humans and approximately 5% metastasize, usually to regional lymph nodes. Epigenetic regulation of gene expression may allow tumoral cells to acquire new functions in order to escape from the primary tumor. The aim of this study was to investigate the expression and function of proteins of the Polycomb family of epigenetic regulators in the metastatic process of cSCC. A higher expression of RING1B and EZH2 was detected by immunohistochemistry in a series of primary cSCC tumors that metastasized (MSCC) when compared to non-metastasizing cSCC (non-MSCC)...
January 31, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29393881/the-role-of-photodynamic-therapy-in-the-treatment-of-vulvar-intraepithelial-neoplasia
#17
REVIEW
Giulio Tosti, Anna Daniela Iacobone, Eleonora Petra Preti, Sabina Vaccari, Alessia Barisani, Elisabetta Pennacchioli, Carmen Cantisani
BACKGROUND: vulvar intraepithelial neoplasia is a non-invasive precursor lesion found in 50-70% of patients affected by vulvar squamous cell carcinoma. In the past, radical surgery was the standard treatment for vulvar intraepithelial neoplasia, however, considering the psychological and physical morbidities related to extensive surgery, several less aggressive treatment modalities have been proposed since the late 1970s. Photodynamic therapy is an effective and safe treatment for cutaneous non-melanoma skin cancer, with favorable cosmetic outcomes...
February 2, 2018: Biomedicines
https://www.readbyqxmd.com/read/29387873/prevalence-and-types-of-genital-lesions-in-organ-transplant-recipients
#18
Kumar S Nadhan, Mary Larijani, James Abbott, Alden M Doyle, Anthony W Linfante, Christina Lee Chung
Importance: Squamous cell carcinoma (SCC) is the most common skin cancer diagnosed in solid organ transplant recipients (OTRs) and confers significant mortality. The development of SCC in the genital region is elevated in nonwhite OTRs. Viral induction, specifically human papillomavirus (HPV), is hypothesized to play a role in the pathophysiology of these lesions. Objective: To assess the prevalence and types of genital lesions observed in OTRs. Design, Setting, and Participants: This retrospective review included 496 OTRs who underwent full skin examination from November 1, 2011, to April 28, 2017, at an academic referral center...
January 31, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29365226/noninfectious-penile-lesions
#19
Joel M H Teichman, Miles Mannas, Dirk M Elston
Noninfectious penile lesions are classified by clinical presentation as papulosquamous (e.g., psoriasis), inflammatory (e.g., lichen sclerosus, lichen nitidus, lichen planus), vascular (e.g., angiokeratomas), or neoplastic (e.g., carcinoma in situ, invasive squamous cell carcinoma). Psoriasis presents as red or salmon-colored plaques with overlying silvery scales, often with extragenital cutaneous lesions. Lichen sclerosus presents as a phimotic, hypopigmented prepuce or glans penis with a cellophane-like texture...
January 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29362353/role-of-xeroderma-pigmentosum-group-d-in-cell-cycle-and-apoptosis-in-cutaneous-squamous-cell-carcinoma-a431-cells
#20
Ou-Gen Liu, Xiao-Yan Xiong, Chun-Ming Li, Xian-Sheng Zhou, Si-Si Li
BACKGROUND Cutaneous squamous cell carcinoma (cSCC) is the second most widespread cancer in humans and its incidence is rising. Novel therapy with better efficacy is needed for clinical treatment of cSCC. Many studies have shown the importance of DNA repair pathways during the development of cancer. A key nucleotide excision repair (NER) protein, xeroderma pigmentosum group D (XPD), is responsible for the excision of a large variety of bulky DNA lesions. MATERIAL AND METHODS To explore the role of XPD in A431 cells, we overexpressed XPD in A431 cells and performed MTT assay, flow cytometry, and Western blot analysis to examine cell proliferation, cell apoptosis, and genes expression...
January 24, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
keyword
keyword
10958
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"