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Cutaneous squamous cell carcinoma

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https://www.readbyqxmd.com/read/28344868/langerhans-cells-and-nk-cells-cooperate-in-the-inhibition-of-chemical-skin-carcinogenesis
#1
Daniela Ortner, Christoph H Tripp, Kerstin Komenda, Sandrine Dubrac, Bernhard Zelger, Martin Hermann, Wolfgang Doppler, Piotr Z Tymoszuk, Louis Boon, Björn E Clausen, Patrizia Stoitzner
Tissue immunosurveillance is an important mechanism to prevent cancer. Skin treatment with the carcinogen 7,12-dimethylbenz(a)anthracene (DMBA), followed by the tumor promoter 12-O-tetra-decanoyl-phorbol-13-acetate (TPA), is an established murine model for squamous cell carcinoma (SCC). However, the innate immunological events occurring during the initiation of chemical carcinogenesis with DMBA remain elusive. Here, we discovered that natural killer (NK) cells and Langerhans cells (LC) cooperate to impair this oncogenic process in murine skin...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28344135/not-just-skin-deep-distant-metastases-from-cutaneous-squamous-cell-carcinoma
#2
Ajay Major, Mel Anderson
No abstract text is available yet for this article.
March 23, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28339425/potential-role-of-the-ovol1-ovol2-axis-and-c-myc-in-the-progression-of-cutaneous-squamous-cell-carcinoma
#3
Takamichi Ito, Gaku Tsuji, Fumitaka Ohno, Takeshi Nakahara, Hiroshi Uchi, Masutaka Furue
OVOL1 and OVOL2 are ubiquitously conserved genes encoding C2H2 zinc-finger transcription factors in mammals. They promote epithelial cell proliferation, differentiation, and mesenchymal-to-epithelial transition, coordinately mediated via the Wnt signaling pathway. We previously reported that human OVOL1 and OVOL2 were preferentially expressed in the normal epidermis and hair follicles as well as their tumors, and found that OVOL1 is upregulated in Bowen's disease and downregulated in cutaneous squamous cell carcinoma...
March 24, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28337777/syringocystadenocarcinoma-papilliferum-clinicopathologic-analysis-of-ten-cases
#4
Yan Zhang, Yun-Yi Kong, Xu Cai, Xu-Xia Shen, Jin-Cheng Kong
BACKGROUND: Syringocystadenocarcinoma papilliferum (SCACP) is an exceedingly rare cutaneous adnexal neoplasm. We aimed to investigate the clinicopathologic and immunophenotypic features of SCACP, and to discuss the prognosis of this rare entity. METHOD: We retrospectively collected clinical, pathological and follow-up data of 10 cases with SCACP. RESULTS: There were 8 males and 2 females, with ages ranging from 26 to 74 years. The chest was most frequently involved...
March 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28337292/mir-217-promotes-cutaneous-squamous-cell-carcinoma-progression-by-targeting-ptrf
#5
Ming Bai, Mingzi Zhang, Fei Long, Nanze Yu, Ang Zeng, Xiaojun Wang
Increasing evidences have suggested that microRNAs (miRNAs) act a critical role in tumor initiation, progression and metastasis. Deregulated expression of miR-217 has been identified in various tumors. However, the expression and role of miR-217 in the development of cutaneous squamous cell carcinoma (cSCC) remain unclear. In our study, we showed that miR-217 expression was upregulated in the cSCC tissues compared to adjacent non-tumor samples. We also demonstrated that miR-217 expression was upregualted in the cSCCcSCC cell lines...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28332498/a-genome-wide-screen-identifies-yap-wbp2-interplay-conferring-growth-advantage-on-human-epidermal-stem-cells
#6
Gernot Walko, Samuel Woodhouse, Angela Oliveira Pisco, Emanuel Rognoni, Kifayathullah Liakath-Ali, Beate M Lichtenberger, Ajay Mishra, Stephanie B Telerman, Priyalakshmi Viswanathan, Meike Logtenberg, Lisa M Renz, Giacomo Donati, Sven R Quist, Fiona M Watt
Individual human epidermal cells differ in their self-renewal ability. To uncover the molecular basis for this heterogeneity, we performed genome-wide pooled RNA interference screens and identified genes conferring a clonal growth advantage on normal and neoplastic (cutaneous squamous cell carcinoma, cSCC) human epidermal cells. The Hippo effector YAP was amongst the top positive growth regulators in both screens. By integrating the Hippo network interactome with our data sets, we identify WW-binding protein 2 (WBP2) as an important co-factor of YAP that enhances YAP/TEAD-mediated gene transcription...
March 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28329670/telomere-length-cutaneous-beta-human-papillomavirus-infection-and-cutaneous-squamous-cell-carcinoma
#7
Shalaka Hampras, Michael Pawlita, Massimo Tommasino, Jong Park, Pearlie Burnette, Neil Fenske, Basil Cherpelis, Dana Rollison
BackgroundCutaneous beta-human papillomavirus (HPV) infection and telomere length have both been associated with cutaneous squamous cell carcinoma (SCC). We examined the interaction between telomere length and beta-HPV in association with SCC.MethodsA subset of SCC cases and controls, enrolled in a previously conducted case-control study (2007-2008) at the University of South Florida and Moffitt Cancer Center, for whom data was available on telomere length and a) beta-HPV serology (135 cases and 201 controls), b) beta-HPV DNA in eyebrow hairs (EB) (130 SCC cases and 195 controls) and c) beta-HPV DNA in SCC tumors (117 cases), were included in the present analyses...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329662/the-preneoplastic-genome-transcriptomic-drivers-of-squamous-cell-carcinoma-development
#8
Kenneth Y Tsai
Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in the U.S. annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). In order to identify potential targets for molecularly targeted chemoprevention, we performed integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar UV- driven Hairless mouse model. We performed RNA-seq and microRNA-seq on samples from both patients undergoing Mohs surgery and the mouse model...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329649/human-papillomavirus-infection-and-squamous-cell-carcinoma-in-organ-transplant-recipients
#9
Jan Nico Bouwes Bavinck
Organ transplant recipients (OTR) have an increased risk of developing squamous cell carcinomas (SCC). SCC are usually associated with multiple warts and premalignant keratoses. This cohort study investigated the predictive effect of infection with beta papillomaviruses (betaPV) with the later development of cutaneous SCC.In an earlier prospective and case-control study, eyebrow hairs and sera of 743 OTR transplanted before 2003 were collected. BetaPV DNA was determined in eyebrow hairs and betaPV antibodies in sera...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329645/frequent-somatic-mutations-of-chromatin-remodeling-genes-in-metastatic-cutaneous-squamous-cell-carcinoma
#10
Amanda Ewart Toland
Exome and targeted sequencing studies have identified potential driver mutations for a variety of tumor types. Cutaneous squamous cell carcinoma (cSCC) is one of the most highly mutated cancers but is typically correlated with high survival rates and low rates of metastasis. Nevertheless, metastatic cSCC is a significant health threat; up to 8800 individuals are estimated to die yearly from this disease. As it is difficult to predict which cSCCs are more likely to metastasize, and because there are no targeted therapies specifically designated for metastatic cSCC, we performed exome and targeted sequencing of 18 metastatic and 10 primary cSCCs to identify mutations with potential therapeutic benefit...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329632/cigarette-smoking-and-the-risks-of-incident-basal-cell-carcinoma-and-squamous-cell-carcinoma-in-a-large-population-based-cohort-study
#11
Jean Claude Dusingize, Catherine M Olsen, Nirmala Pandeya, Bridie Thompson, Rachel E Neale, Padmini Subramaniam, David C Whiteman, Adele C Green
Tobacco smoking is a strong risk factor for cancer, but associations with basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) of the skin have been inconsistent. We prospectively investigated the associations between cigarette smoking and 3-year incidence of first primary BCC or SCC in the QSkin cohort (n=43765). Smoking history was self-reported at baseline; newly diagnosed and surgically treated BCCs and SCCs were ascertained through linkage to the national health insurance scheme and verified by histopathology reports...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329481/cutaneous-leishmaniasis-mimicking-squamous-cell-carcinoma
#12
Tara Oetken, Bryan Hiscox, Ida Orengo, Theodore Rosen
A 41-year-old man from Cuero, Texas with a nonhealinglesion on his left cheek was referred to ourclinic for removal of a squamous cell carcinoma. Thepatient first noticed a "pimple" on his left cheek 3-4months prior to presentation. When the lesion beganto grow he presented to his primary care physician anda biopsy was taken, showing "atypical squamous cellproliferation." Mohs surgery was performed and thenodule was removed with no evidence of malignancyseen on histopathology. Upon review of the surgicalbiopsies by consulting pathologists, the diagnosis ofleishmaniasis was established and later confirmed bythe Center for Disease Control and Prevention (CDC)as Leishmania mexicana...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329421/naproxen-inhibits-uvb-induced-basal-cell-and-squamous-cell-carcinoma-development-in-ptch1-skh-1-hairless-mice
#13
Sandeep C Chaudhary, Mohammad Waseem, Mehtab Rana, Hui Xu, Levy Kopelovich, Craig A Elmets, Mohammad Athar
Naproxen possesses anti-proliferative and pro-apoptotic effects besides its known anti-inflammatory functions. Here, we demonstrate the anti-cancer effects of naproxen against UVB-induced BCCs and SCCs in a highly susceptible murine model of UVB carcinogenesis. Naproxen significantly inhibited UVB-induced BCCs and SCCs in this model. Tumor number and volume were significantly decreased (p<0.005 and p<0.05, respectively). Inhibition in UVB-induced SCCs and BCCs was 77% and 86%, respectively, which was associated with reduced PCNA and cyclin D1 and increased apoptosis...
March 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28322200/complement-component-c3-and-complement-factor-b-promote-growth-of-cutaneous-squamous-cell-carcinoma
#14
Pilvi Riihilä, Liisa Nissinen, Mehdi Farshchian, Markku Kallajoki, Atte Kivisaari, Seppo Meri, Reidar Grénman, Sirkku Peltonen, Juha Peltonen, Taina Pihlajaniemi, Ritva Heljasvaara, Veli-Matti Kähäri
Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8) and normal human epidermal keratinocytes (n = 11) with real-time quantitative PCR and Western blotting revealed up-regulation of C3 and CFB expression in cSCC cells. Immunohistochemical staining revealed stronger tumor cell-specific labeling for C3 and CFB in invasive cSCCs (n = 71) and recessive dystrophic epidermolysis bullosa-associated cSCCs (n = 11) than in cSCC in situ (n = 69), actinic keratoses (n = 63), and normal skin (n = 5)...
March 16, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28322123/factors-associated-with-recurrence-and-regional-adenopathy-for-head-and-neck-cutaneous-squamous-cell-carcinoma
#15
Brianna N Harris, Ahmed Bayoumi, Shyam Rao, Michael G Moore, D Gregory Farwell, Arnaud F Bewley
Objective Cutaneous squamous cell carcinoma (CSCC) is one of the most common malignancies worldwide. With advanced CSCC of the head and neck, there is conflicting evidence on what constitutes high-risk disease. Our objective is to evaluate which factors are predictive of recurrence and nodal spread and survival. Study Design Case series with chart review. Setting Tertiary academic institution. Subjects and Methods Patients with advanced head and neck CSCC treated with primary resection identified by chart review...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28314684/the-adverse-prognostic-effect-of-tumor-budding-on-the-evolution-of-cutaneous-head-and-neck-squamous-cell-carcinoma
#16
Miriam Gonzalez-Guerrero, Pablo Martínez-Camblor, Blanca Vivanco, Ivan Fernández-Vega, Pablo Munguía-Calzada, Maria Paz Gonzalez-Gutierrez, Juan Pablo Rodrigo, Cristina Galache, Jorge Santos-Juanes
BACKGROUND: Tumor budding is a readily detectable histopathologic feature that has been recognized as an adverse prognostic factor in several human cancers. OBJECTIVE: We sought to assess the correlation of tumor budding with the clinicopathologic features and the prognostic value of tumor budding in cutaneous squamous cell carcinoma (cSCC). METHODS: Forty-nine primary nonmetastatic and 49 primary metastatic cSCCs to regional lymph nodes were retrospectively studied...
March 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28295401/staging-cutaneous-squamous-cell-carcinoma-metastases-to-the-parotid-gland
#17
Lukasz Czerwonka, Robert J De Santis, Gilad Horowitz, Michael Hong, Mario Orsini, Danny Enepekides, David P Goldstein, Joe Dort, Kevin Higgins
OBJECTIVE: The staging of cutaneous squamous cell cancers (cSCC) was revised by the American Joint Committee on Cancer in 2010 to incorporate known prognostic factors and expand the N (node) category. The purpose of this study was to validate this staging system using a North American cohort, and to compare it to the O'Brien P (Parotid) and N staging system. METHODS: An exhaustive collaborative database search was performed for all patients with cSCC metastasis to the parotid gland treated at three major Canadian tertiary referral centers from December 1999 to March 2015...
March 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28293492/a-rare-case-of-malignant-transformation-of-oral-lichen-planus-of-the-mandible
#18
Joanne Soo, George Kokosis, Michael Ogilvie, Xiaoyin Sara Jiang, David B Powers, Daniel J Rocke, Detlev Erdmann
Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant transformation to OSCC. Delineating the margins of the disease was impossible at presentation given her OLP, and she was initially treated with concurrent chemoradiation therapy...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28281550/reduced-h3k27me3-expression-in-merkel-cell-polyoma-virus-positive-tumors
#19
Klaus J Busam, Melissa P Pulitzer, Daniel C Coit, Maria Arcila, Danielle Leng, Achim A Jungbluth, Thomas Wiesner
Merkel cell carcinoma is a primary cutaneous neuroendocrine carcinoma, which once metastatic is difficult to treat. Recent mutation analyses of Merkel cell carcinoma revealed a low number of mutations in Merkel cell polyomavirus-associated tumors, and a high number of mutations in virus-negative combined squamous cell and neuroendocrine carcinomas of chronically sun-damaged skin. We speculated that the paucity of mutations in virus-positive Merkel cell carcinoma may reflect a pathomechanism that depends on derangements of chromatin without alterations in the DNA sequence (epigenetic dysregulation)...
March 10, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28274513/pctaire1-cdk16-pctk1-is-overexpressed-in-cutaneous-squamous-cell-carcinoma-and-regulates-p27-stability-and-cell-cycle
#20
Teruki Yanagi, Hiroo Hata, Eri Mizuno, Shinya Kitamura, Keisuke Imafuku, Shinichi Nakazato, Lei Wang, Hiroshi Nishihara, Shinya Tanaka, Hiroshi Shimizu
BACKGROUND: PCTAIRE1 (also known as cyclin-dependent kinase 16 (Cdk16) and PCTK1) is a Cdk family protein that has been implicated in spermatogenesis. We recently revealed the function of PCTAIRE1 in the tumorigenesis of malignancies, including breast and prostate cancers; however, the tumorigenic function of PCTAIRE1 in cutaneous squamous cell carcinoma (SCC) remains unclear. OBJECTIVE: In this study, we investigated the role of PCTAIRE1 in the tumorigenesis of cutaneous SCCs...
February 22, 2017: Journal of Dermatological Science
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