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Cutaneous squamous cell carcinoma

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https://www.readbyqxmd.com/read/29053046/microcystic-adnexal-carcinoma-of-the-orbit-mimicking-pagetoid-sebaceous-gland-carcinoma
#1
Bipasha Mukherjee, Nirmala Subramaniam, Krishna Kumar, Pratheeba Devi Nivean
Microcystic adnexal carcinoma (MAC) is a rare malignancy of sweat glands that has been reported most often on the face in the form of a cutaneous lesion, with the potential for deeper invasion. The synonyms of MAC include sclerosing sweat duct carcinoma, syringomatous carcinoma, and malignant syringoma. Clinically, MAC in the periocular area has been misdiagnosed as basal cell carcinoma, squamous cell carcinoma, or even chalazia. We report a case of MAC presenting clinically as sebaceous gland carcinoma with pagetoid spread for the first time in literature...
October 20, 2017: Orbit
https://www.readbyqxmd.com/read/29052902/towards-the-use-of-precision-medicine-in-predicting-cutaneous-squamous-cell-carcinoma-risk-among-solid-organ-transplant-recipients
#2
M O Nguyen, H T Nguyen, M M Asgari
No abstract text is available yet for this article.
October 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29049841/predictive-value-of-the-8th-edition-american-joint-commission-cancer-ajcc-nodal-staging-system-for-patients-with-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#3
Jessica Liu, Ardalan Ebrahimi, Tsu-Hui Hubert Low, Kan Gao, Carsten E Palme, Ch'ng Sydney, Bruce G Ashford, N Gopalakrishna Iyer, Jonathan R Clark, Ruta Gupta
BACKGROUND: The 8th edition American Joint Committee on Cancer (AJCC8) provides the same nodal staging system for mucosal and cutaneous squamous cell carcinoma of the head and neck (HNcSCC) and includes extranodal extension (ENE) as an adverse prognostic criterion. This study evaluates the prognostic efficacy of the AJCC8 pathologic nodal staging system (pN) for HNcSCC. METHODS: Univariate analysis of 382 patients with metastatic HNcSCC staged according to both the 7th (AJCC7) and the 8th edition staging systems...
October 19, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29049612/long-term-change-in-the-risk-of-skin-cancer-after-organ-transplantation-a-population-based-nationwide-cohort-study
#4
Syed Mohammad Husain Rizvi, Bjarte Aagnes, Hallvard Holdaas, Einar Gude, Kristin Muri Boberg, Øystein Bjørtuft, Per Helsing, Torbjørn Leivestad, Bjørn Møller, Petter Gjersvik
Importance: The high risk of skin cancer after organ transplantation is a major clinical challenge and well documented, but reports on temporal trends in the risk of posttransplant cutaneous squamous cell carcinoma (SCC) are few and appear contradictory. Objective: To study temporal trends for the risk of skin cancer, particularly SCC, after organ transplantation. Design, Setting, and Participants: Population-based, nationwide, prospective cohort study of 8026 patients receiving a kidney, heart, lung, or liver transplant in Norway from 1968 through 2012 using patient data linked to a national cancer registry...
October 18, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29029040/herbacetin-suppresses-cutaneous-squamous-cell-carcinoma-and-melanoma-cell-growth-by-targeting-akt-and-odc
#5
Dong Joon Kim, Mee-Hyun Lee, KangDong Liu, Do Young Lim, Eunmiri Roh, Hanyong Chen, Sung-Hyun Kim, Jung-Hyun Shim, Myoung Ok Kim, Wenwen Li, Fayang Ma, Mangaladoss Fredimoses, Ann M Bode, Zigang Dong
Herbacetin is a flavonol compound that is found in plants such as flaxseed and ramose scouring rush herb, it possesses a strong antioxidant capacity, and exerts anticancer effects on colon and breast cancer. However, the effect of herbacetin on skin cancer has not been investigated. Herein, we identified herbacetin as a dual V-akt murine thymoma viral oncogene homolog (AKT) and ornithine decarboxylase (ODC) inhibitor, and illustrated its anticancer effects in vitro and in vivo against cutaneous squamous cell carcinoma (SCC) and melanoma cell growth...
September 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29024374/human-papillomavirus-and-post-transplant-cutaneous-squamous-cell-carcinoma-a-multicenter-prospective-cohort-study
#6
Jan Nico Bouwes Bavinck, Mariet C W Feltkamp, Adele C Green, Marta Fiocco, Sylvie Euvrard, Catherine A Harwood, Charlotte M Proby, Luigi Naldi, Janouk C D Diphoorn, Anna Venturuzzo, Gianpaolo Tessari, Ingo Nindl, Francesca Sampogna, Damiano Abeni, Rachel E Neale, Jelle J Goeman, Koen D Quint, Anne Berthe Halk, Carmen Sneek, Roel E Genders, Maurits N C de Koning, Wim G V Quint, Ulrike Wieland, Sönke Weissenborn, Tim Waterboer, Michael Pawlita, Herbert Pfister
Organ-transplant recipients (OTR) have a 100-fold increased risk of cutaneous squamous-cell carcinoma (cSCC). We prospectively evaluated the association between beta-genus human-papillomaviruses (betaPV) and keratinocyte carcinoma in OTR. Two OTR cohorts without cSCC were assembled: cohort 1 transplanted in 2003-2006 (n=274) and cohort 2 in 1986-2002 (n=352). Participants were followed until death or cessation of follow-up in 2016. BetaPV infection was assessed in eyebrow hairs using PCR-based methods. BetaPV IgG seroresponses were determined by multiplex serology...
October 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29019175/isolated-limb-infusion-a-single-center-experience-with-over-200-infusions
#7
Cristina O'Donoghue, Matthew C Perez, John E Mullinax, Danielle Hardman, Sean Sileno, Syeda Mahrukh Hussnain Naqvi, Youngchul Kim, Ricardo J Gonzalez, Jonathan S Zager
BACKGROUND: Isolated limb infusion (ILI) is a minimally invasive technique for delivering regional chemotherapy to an extremity for patients with locally advanced cutaneous malignancies and sarcoma. METHODS: A single-institution, prospectively collected database was analyzed for intention-to-treat with ILI. RESULTS: From 2007 to 2016, 163 patients underwent 205 procedures (201 were successfully completed), and four malignancies were treated: melanoma (72...
October 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29018888/-non-melanoma-skin-cancer-pathogenesis-prevalence-and-prevention
#8
A Zink
Non-melanoma skin cancer (NMSC) is the most common malignancy of the light-skinned population with an enormous socioeconomic impact. Historically known as incurable under the term noli me tangere (transl. do not touch me), today various non-melanocytic cutaneous neoplasms are grouped as NMSC. The most common of these, basal cell carcinoma, squamous cell carcinoma and actinic keratoses as carcinomas in situ, are increasingly called keratinocyte carcinoma. Today, the pathogenesis and risk factors of NMSC are relatively well understood, which has led to multiple treatment options, the recognition of NMSC as an occupational disease in Germany and a variety of prevention approaches...
October 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28994104/epidemiology-of-keratinocyte-carcinomas-after-organ-transplantation
#9
REVIEW
M M Madeleine, N S Patel, E I Plasmeijer, E A Engels, J N Bouwes Bavinck, A E Toland, A C Green
Keratinocyte carcinoma (KC) is the most common type of cancer among white populations, but it is even more common among solid organ transplant recipients (OTRs). The most frequent histological type of KC among OTRs is cutaneous squamous cell carcinoma (cSCC), followed by basal cell carcinoma, although the reverse is seen in the general population. Metastatic cSCCs are more frequent, and mortality is increased compared with immunocompetent populations. There is strong evidence that the risk of KC among OTRs rises with increasing time after transplantation and older age at transplantation, and that KC is enhanced in those with sun-damaged skin...
October 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28984303/analysis-of-clinically-relevant-somatic-mutations-in-high-risk-head-and-neck-cutaneous-squamous-cell-carcinoma
#10
Catherine Zilberg, Matthew Weicai Lee, Bing Yu, Bruce Ashford, Spiridoula Kraitsek, Marie Ranson, Kerwin Shannon, Mark Cowley, N Gopalakrishna Iyer, Carsten E Palme, Sydney Ch'ng, Tsu-Hui Hubert Low, Sandra O'Toole, Jonathan R Clark, Ruta Gupta
Cutaneous squamous cell carcinoma is the second most prevalent malignancy, most frequently occurring in the head and neck (head and neck cutaneous squamous cell carcinoma). Treatment of locally advanced or metastatic disease is associated with functional morbidity and disfigurement. Underlying genetic mechanisms are poorly understood. Targeted sequencing of 48 clinically relevant genes was performed on DNA extracted from formalin-fixed and paraffin-embedded high-risk primary head and neck cutaneous squamous cell carcinomas that remained non-metastatic at minimum follow-up of 24 months...
October 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28978917/chronic-sun-exposure-related-fusion-oncogenes-egfr-ppargc1a-in-cutaneous-squamous-cell-carcinoma
#11
Sho Egashira, Masatoshi Jinnin, Manami Ajino, Naoki Shimozono, Sayo Okamoto, Yukino Tasaki, Ayaka Hirano, Maho Ide, Ikko Kajihara, Jun Aoi, Miho Harada, Toshikatsu Igata, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn
Cutaneous squamous cell carcinoma (cSCC) differs from SCC of other organs in its strong association with chronic sun exposure. However, the specific driver mutations in cSCC remain unknown. Fusion genes in established cSCC cell lines (A431 and DJM-1) were predicted by transcriptome sequence, and validated by Sanger sequence, fluorescence in situ hybridization and G-banding. By transcriptome sequencing, we identified fusion gene EGFR-PPARGC1A in A431, which were expressed in 31 of 102 cSCCs. The lesions harboring the fusion gene tended to be located in sun-exposed areas...
October 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28966807/skin-cancer-epidemics-in-the-elderly-as-an-emerging-issue-in-geriatric-oncology
#12
REVIEW
Simone Garcovich, Giuseppe Colloca, Pietro Sollena, Bellieni Andrea, Lodovico Balducci, William C Cho, Roberto Bernabei, Ketty Peris
Skin cancer is a worldwide, emerging clinical need in the elderly white population, with a steady increase in incidence rates, morbidity and related medical costs. Skin cancer is a heterogeneous group of cancers comprising cutaneous melanoma and non-melanoma skin cancers (NMSC), which predominantly affect elderly patients, aged older than 65 years. Melanoma has distinct clinical presentations in the elderly patient and represents a challenging question in terms of clinical management. NMSC includes the basal cell carcinoma and cutaneous squamous cell carcinoma and presents a wide disease spectrum in the elderly population, ranging from low-risk to high-risk tumours, advanced and inoperable disease...
October 2017: Aging and Disease
https://www.readbyqxmd.com/read/28964539/gefitinib-for-patients-with-incurable-cutaneous-squamous-cell-carcinoma-a-single-arm-phase-ii-clinical-trial
#13
William N William, Lei Feng, Renata Ferrarotto, Lawrence Ginsberg, Merrill Kies, Scott Lippman, Bonnie Glisson, Edward S Kim
BACKGROUND: Preclinical data demonstrate a key role for the epidermal growth factor receptor (EGFR) in the carcinogenesis of cutaneous squamous cell carcinomas (CSCCs). There are, however, limited data on the efficacy of EGFR inhibitors in incurable, recurrent, and/or metastatic CSCC. OBJECTIVE: To determine the response rate to gefitinib in patients with CSCC not amenable to curative therapy including surgery or radiation. METHODS: This was a single-arm phase II study...
September 27, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28963614/efficacy-of-vemurafenib-treatment-in-43-metastatic-melanoma-patients-with-braf-mutation-single-institute-retrospective-analysis-early-real-life-survival-data
#14
Kata Czirbesz, Eszter Gorka, Tímea Balatoni, Gitta Pánczél, Krisztina Melegh, Péter Kovács, András Gézsi, Gabriella Liszkay
BRAF inhibitor vemurafenib achieved improved overall survival over chemotherapy and have been approved by the FDA and EMA for the treatment of BRAF-mutated metastatic melanoma. The aim of our retrospective analysis was to determine the efficacy and safety of vemurafenib therapy for BRAF mutated metastatic melanoma and subsequently to prove the clinical benefit for the studied 43 patients, based on real-life data. From November 2012 to October 2015 we have selected 43 BRAF mutated, metastatic melanoma patients, treated with vemurafenib...
September 29, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28953015/psammomatous-squamous-cell-carcinoma-of-the-skin
#15
Andrew Schuler, Emily Smith, Stephanie Chen, May P Chan, Paul W Harms
Psammoma bodies (PBs) are concentric, lamellated calcifications commonly observed in malignancies such as papillary thyroid carcinoma and serous carcinoma of the ovary in which they may serve prognostic value. PBs are rare in cutaneous squamous cell carcinoma (cSCC), with only 1 previously reported case. Here, we present 3 cases of cSCC displaying PBs. One case occurred in the setting of end-stage renal disease, whereas the other 2 cases were in patients who did not have comorbid conditions that might predispose to hypercalcemia and dystrophic calcification...
September 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28952162/risk-prediction-tools-for-keratinocyte-carcinoma-after-solid-organ-transplantation-a-review-of-the-literature
#16
REVIEW
S E Lowenstein, G Garrett, A E Toland, A Jambusaria-Pahlajani, M M Asgari, A Green, E A Engels, S T Arron
Long-term iatrogenic immunosuppression increases the risk of cutaneous malignancies in organ transplant recipients (OTRs), particularly the keratinocyte cancers basal cell carcinoma and cutaneous squamous cell carcinoma (cSCC). cSCC is the most common malignancy in OTRs, with the risk increased to over 65-fold in transplanted patients relative to the general population. There have been very few risk prediction tools developed for accurate determination of the risk of developing keratinocyte cancers in the OTR population...
September 26, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28951130/accumulation-of-cytoplasmic-cdc25a-in-cutaneous-squamous-cell-carcinoma-leads-to-a-dependency-on-cdc25a-for-cancer-cell-survival-and-tumor-growth
#17
Jenan Al-Matouq, Thomas Holmes, Brianna Hammiller, Nicholas Tran, Matti Holmes, S Caleb Freeman, Laura A Hansen
Despite its documented role in cell cycle regulation, over-expression of the cyclin-dependent kinase activator CDC25A does not consistently correlate with worse cancer patient outcomes or predict successful clinical response to CDC25A inhibition. The current study was undertaken to investigate CDC25A in skin cancer and understand predictors of positive response to CDC25A targeting. CDC25A was increased in human squamous cell carcinoma (SCC) associated with a shift from a primarily nuclear localization in skin to a strong cytoplasmic localization in SCC, a pattern that was reproduced in skin cancer cell lines...
September 23, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28941263/epidermodysplasia-verruciformis-three-case-reports-and-a-brief-review
#18
Sharma Shruti, Fouzia Siraj, Avninder Singh, V Ramesh
Epidermodyplasia verruciformis (EV) is a rare heritable disease that is characterized by an increased susceptibility to infection with specific human papillomavirus (HPV) types due to a defect in cell-mediated immune response to HPV infection. Widespread infection with HPV is responsible for the development of wart-like lesions and pityriasis versicolor-like spots. These individuals have a lifelong risk of developing cutaneous malignancies, especially Bowen's disease and squamous cell carcinoma, mainly in sun-exposed parts...
September 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28935002/spontaneous-development-of-cutaneous-squamous-cell-carcinoma-in-mice-with-cell-specific-deletion-of-inhibitor-of-%C3%AE%C2%BAb-kinase-2
#19
Kelly S Kirkley, Kelly D Walton, Colleen Duncan, Ronald B Tjalkens
The deletion of NFκB in epithelial tissues by using skin-specific promoters can cause both tumor formation and severe inflammatory dermatitis, indicating that this signaling pathway is important for the maintenance of immune homeostasis in epithelial tissues. In the present study, we crossed mice transgenic for loxP-Ikbk2 and human Gfap-cre to selectively delete IKK2 in CNS astrocytes. Unexpectedly, a subset of mice developed severe and progressive skin lesions marked by hyperplasia, hyperkeratosis, dysplasia, inflammation, and neoplasia with a subset of lesions diagnosed as squamous cell carcinoma (SCC)...
October 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28932782/complete-pathologic-response-of-metastatic-cutaneous-squamous-cell-carcinoma-and-allograft-rejection-after-treatment-with-combination-immune-checkpoint-blockade
#20
David M Miller, Beverly E Faulkner-Jones, James R Stone, Reed E Drews
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
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