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Cutaneous squamous cell carcinoma

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https://www.readbyqxmd.com/read/29245095/a-synchronous-incidence-of-eccrine-porocarcinoma-of-the-forearm-and-facial-squamous-cell-carcinoma-a-case-report
#1
Nandinii Ramasenderan, Hasliza Shahir, Siti Zarqah Omar
INTRODUCTION: Cutaneous appendageal tumor can differentiate towards or arise from either pilosebaceous apparatus or the eccrine sweat glands. Appendageal tumors are relatively rare, their clinical appearance is non-specific, and the vast majority are not diagnosed until after excision. Eccrine porocarcinoma (EP), also known as malignant eccrine poroma is a rare adnexal tumor arising from the intraepithelial ductal parts of the sweat gland. CASE PRESENTATION: We presented a 65-year-old, Asian, female with medical co-morbids, who came with both a facial squamous cell carcinoma and a long-standing lesion over her left forearm...
December 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29241101/marjolin-s-ulcer-in-a-20-years-old-split-thickness-skin-graft-on-the-knee-a-case-report
#2
Iselin Saltvig, Steen H Matzen
OBJECTIVE: Marjolin's Ulcer (MU) is a rare cutaneous neoplasm arising in cikatrical tissue. Due to its typical clinical presentation as a non-healing lesion in scar tissue, the diagnosis can be delayed and even overlooked. METHODS AND RESULTS: We present the case of an elderly woman who developed an ulcerated, exophytic lesion in a split thickness skin graft (STSG) on the lateral aspect of the left knee. Histology showed a radically excised highly differentiated squamous cell carcinoma (SCC) with keratine pearls and a component of basocellular carcinoma (BCC)...
December 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29238073/stage-dependent-therapeutic-efficacy-in-pi3k-mtor-driven-squamous-cell-carcinoma-of-the-skin
#3
Charbel Darido, Smitha R Georgy, Carleen Cullinane, Darren D Partridge, Rachael Walker, Seema Srivastava, Suraya Roslan, Marina R Carpinelli, Sebastian Dworkin, Richard B Pearson, Stephen M Jane
Cutaneous squamous cell carcinoma (SCC) is a recurrent cancer that is prevalent in predisposed subjects such as immunosuppressed patients and patients being treated for other malignancies. Model systems to trial therapies at different stages of SCC development are lacking, therefore precluding efficient therapeutic interventions. Here, we have disrupted the expression of the tumor suppressor GRHL3 to induce loss of PTEN and activation of the PI3K/mTOR signaling pathway in mice and human skin, promoting aggressive SCC development...
December 13, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29231248/slurp-1-is-mutated-in-mal-de-meleda-a-potential-molecular-signature-for-melanoma-and-a-putative-squamous-lineage-tumor-suppressor-gene
#4
Christina Bergqvist, Humam Kadara, Lamiaa Hamie, Georges Nemer, Remi Safi, Mirna Karouni, Nadine Marrouche, Ossama Abbas, Divina J Hasbani, Abdul G Kibbi, Dany Nassar, Yutaka Shimomura, Mazen Kurban
BACKGROUND: Mal de Meleda (MDM) is a rare inherited autosomal recessive genodermatosis characterized by palmoplantar keratoderma (PPK) with transgrediens and caused by mutations in the SLURP1 gene. Uncommonly, cutaneous tumors have been found at PPK sites in MDM patients. OBJECTIVE: To study a Middle Eastern family with MDM with both PPK and skin tumors. METHODS: We studied a Middle Eastern (Palestinian) family with clinical features of MDM and cutaneous tumors...
December 12, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29227042/ex-vivo-confocal-microscopy-features-of-cutaneous-squamous-cell-carcinoma
#5
Daniela Hartmann, Sebastian Krammer, Mario Raphael Bachmann, Leonie Mathemeier, Thomas Ruzicka, Isin Sinem Bagci, Tanja von Braunmühl
BACKGROUND: Rapid microscopic evaluation of cutaneous squamous cell carcinoma (SCC), its grade of differentiation and level of invasiveness would enable better management of patients' therapy. OBJECTIVES: Analyzing specific ex-vivo confocal microscopy criteria whether they can predict diagnosis of invasive SCC vs. carcinoma in situ and poorly differentiated or undifferentiated vs. well and moderately differentiated SCC. METHODS: Ex-vivo confocal images of 102 SCCs in 57 patients were evaluated immediately after excision for the presence of predefined criteria based on confocal and histological knowledge...
December 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29218279/non-metastatic-non-melanoma-skin-cancers-our-3-years-of-clinical-experiences
#6
Elif Sari
BACKGROUND: Nonmelanoma skin cancers (NMSC) constitute the largest group of skin cancers. In this study, NMSCs were analyzed retrospectively. METHODS: Between June 2013 and March 2017, demographics and comorbidities of patients underwent reconstructive surgery for NMSC; their risk factors, types, diameters, differentiation, localizations, follow-up times, treatment methods and complications were compared and statistically analyzed. RESULTS: Totally, 163 tumors [111 basal cell carcinoma and 52 cutaneous squamous cell carcinoma (cSCC)] were excized from 148 patients (63 females, 85 males)...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29209797/-morphology-of-non-cutaneous-head-and-neck-squamous-cell-carcinoma
#7
REVIEW
W Weichert, S Ihrler, M Boxberg, A Agaimy, M Mollenhauer, A Hartmann
Head and neck squamous cell carcinoma (HNSCC) is by far the most frequent malignant tumor in this anatomic region. Today, HNSCC is divided into two morphologically, molecularly and clinically fundamentally different entities: conventional and virus-associated (HPV/EBV) neoplasms. Premalignant lesions of nonvirus-associated HNSCC include conventional leukoplakia, dysplasia and proliferative verrucous hyperplasia with an increasing risk for malignant transformation. The morphology of HNSCC comprises a spectrum of growth patterns...
December 5, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29207610/integration-of-micrornaome-proteomics-and-metabolomics-to-analyze-arsenic-induced-malignant-cell-transformation
#8
Youyou Zhou, Yanfu Wang, Juan Su, Zheng Wu, Chao Wang, Weiming Zhong, Xiaomei Liu, Linhui Cui, Xiaoyu Zhou, Yufang Ma, Yi Xin, Jianglin Zhang, Lisha Wu, Xing Hu, Xiang Chen, Cong Peng, MingYang Gao
Long-term exposure to arsenic has been linked to tumorigenesis in different organs and tissues, such as skin; however, the detailed mechanism remains unclear. In this present study, we integrated "omics" including microRNAome, proteomics and metabolomics to investigate the potential molecular mechanisms. Compared with non-malignant human keratinocytes (HaCaT), twenty-six miRNAs were significantly altered in arsenic-induced transformed cells. Among these miRNAs, the differential expression of six miRNAs was confirmed using Q-RT-PCR, representing potential oxidative stress genes...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29202490/-metastasation-of-cutaneous-squamous-cell-carcinoma-in-the-ent-area
#9
Alexander Dellweg, Thomas Mantei
Objectives Our aim was to investigate the metastasis behavior and its prognostic Factor for Survival, with our clinical data. Materials and methods This retrospective study included 29 Caucasians, with a squamous cell carcinoma of the skin in the head and neck region, at our tertiary clinic between 2004 and 2016. All Patients received a Tumorresection and Neckdissection. We used either Ultrasound or Computer-Tomography (conventional or PET-CT) for our preoperative Staging and the Follow-up. The Patients were classified according to metastatic behavior and the corresponding survival rates were determined...
December 4, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29192981/organ-transplantation-and-cutaneous-squamous-cell-carcinoma-progress-pitfalls-and-priorities-in-immunosuppression-associated-keratinocyte-carcinoma
#10
EDITORIAL
C A Harwood, S T Arron, C M Proby, M M Asgari, J N Bouwes Bavinck, A C Green, A E Toland
No abstract text is available yet for this article.
November 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29190285/the-interplay-of-uv-and-cutaneous-papillomavirus-infection-in-skin-cancer-development
#11
Daniel Hasche, Sonja Stephan, Ilona Braspenning-Wesch, Julita Mikulec, Martina Niebler, Hermann-Josef Gröne, Christa Flechtenmacher, Baki Akgül, Frank Rösl, Sabrina E Vinzón
Cutaneous human papillomaviruses (HPVs) are considered as cofactors for non-melanoma skin cancer (NMSC) development, especially in association with UVB. Extensively studied transgenic mouse models failed to mimic all aspects of virus-host interactions starting from primary infection to the appearance of a tumor. Using the natural model Mastomys coucha, which reflects the human situation in many aspects, we provide the first evidence that only UVB and Mastomys natalensis papillomavirus (MnPV) infection strongly promote NMSC formation...
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29178483/electrochemotherapy-of-unresectable-cutaneous-tumors%C3%A2-with-reduced-dosages-of-intravenous-bleomycin-analysis-of-57-patients-from-the-inspect-international-network-for-sharing-practices-of-electrochemotherapy-registry
#12
R Rotunno, L G Campana, P Quaglino, F de Terlizzi, C Kunte, J Odili, J Gehl, S Ribero, S H Liew, R Marconato, M Brizio, P Curatolo
BACKGROUND: Electrochemotherapy (ECT) is currently used to treat unresectable superficial tumors of different histotypes through the combination of cytotoxic chemotherapy and local application of electric pulses. In 2006, a collaborative project defined the ESOPE (European Standard Operating Procedures of Electrochemotherapy) guidelines to standardize the procedure. The International Network for Sharing Practices of Electrochemotherapy (InspECT) aims to to refine the ESOPE and improve clinical practice...
November 24, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29176966/induction-of-tyrosine-phosphorylation-of-uv-activated-egfr-by-the-beta-human-papillomavirus-type-8-e6-leads-to-papillomatosis
#13
Stefanie Taute, Herbert J Pfister, Gertrud Steger
Epidemiological evidence is accumulating that beta-human papillomaviruses (HPV) synergize with UV-light in the development of precancerous actinic keratosis, and cutaneous squamous cell carcinomas (cSCC), one of the most common cancers in the Caucasian population. We previously demonstrated the tumorigenic activity of beta-HPV type 8 (HPV8) in the skin of transgenic mice and its cooperation with UV-light. Analysis of underlying mechanisms now showed that in keratinocytes expressing the HPV8E6 protein a transient increase of tyrosine phosphorylated epidermal growth factor receptor (EGFR) in response to UV-irradiation occurred, while EGFR tyrosine phosphorylation, i...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29176271/patterns-of-ultraviolet-radiation-exposure-and-skin-cancer-risk-the-e3n-sunexp-study
#14
Isabelle Savoye, Catherine M Olsen, David C Whiteman, Anne Bijon, Lucien Wald, Laureen Dartois, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Marina Kvaskoff
BACKGROUND: While ultraviolet (UV) radiation exposure is a recognized risk factor for skin cancer, associations are complex and few studies have allowed a direct comparison of exposure profiles associated with cutaneous melanoma, basal-cell carcinoma (BCC), and squamous-cell carcinoma (SCC) within a single population. METHODS: We examined associations between UV exposures and skin cancer risk in a nested case-control study within E3N, a prospective cohort of 98,995 French women born in 1925-1950...
November 25, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29174519/importance-of-sentinel-lymphatic-node-biopsy-in-detection-of-early-micrometastases-in-patients-with-cutaneous-squamous-cell-carcinoma
#15
Donatas Samsanavicius, Vygintas Kaikaris, Adas Cepas, Jens Ulrich, Jurgita Makstiene, Rytis Rimdeika
BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) is the second most common malignant skin cancer with a tendency to spread through the lymphogenic pathway. Metastases are found in 2-6% of cases. The aim of this study was to determine CSCC micrometastases when non-invasive examination methods do not detect them. METHOD: A total of 88 patients were included in the study with clinically diagnosed, histologically confirmed CSCC and no distant or regional lymph node metastases detected during instrumental tests...
November 23, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29172905/retrospective-study-of-more-than-9000-feline-cutaneous-tumours-in-the-united-kingdom-2006-2013
#16
Nicola T Ho, Ken C Smith, Melanie J Dobromylskyj
Objectives The aim of the study was to utilise a large database available from a UK-based, commercial veterinary diagnostic laboratory to ascertain the prevalence of different forms of cutaneous neoplasia within the feline population, and to detect any breed, sex or age predilections for the more common tumours. Methods Records from the laboratory were searched for feline submissions received between 31 May 2006 and 31 October 2013. For masses arising within the skin for which histopathology had been performed, the diagnosis was recorded together with the breed, age, sex and neuter status of the cat...
March 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29167858/cutaneous-squamous-cell-carcinomas-in-solid-organ-transplant-recipients-compared-with-immunocompetent-patients
#17
Joyce Y Cheng, Fang-Yong Li, Christine J Ko, Oscar R Colegio
Importance: Solid organ transplant recipients (SOTRs) have a 100-fold increased risk of squamous cell carcinoma (SCC), and they may develop more aggressive SCCs compared with immunocompetent individuals. Objective: To compare outcomes associated with aggressive behavior of SCC in SOTRs and high-risk immunocompetent patients. Design, Setting, and Participants: A retrospective cohort study of 58 SOTRs and 40 immunocompetent patients evaluated at the Yale Transplant Dermatology Clinic in New Haven, Connecticut, who had at least 1 SCC confirmed histopathologically between January 1, 2008, and December 31, 2015...
November 22, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29166500/final-diagnosis-of-86-cases-included-in-differential-diagnosis-of-american-tegumentary-leishmaniasis-in-a-brazilian-sample-a-retrospective-cross-sectional-study
#18
Fernanda Tirelli, Sebastian Vernal, Ana Maria Roselino
BACKGROUND: Cutaneous leishmaniasis is distributed worldwide, including Brazil. Its several clinical forms need to be distinguished from other dermatoses. Clinical similarities and lack of a gold standard diagnostic tool make leishmaniasis-like lesions a challenging diagnosis. OBJECTIVES.: To report the final diagnosis of patients primarily suspected of having American tegumentary leishmaniasis (ATL). METHODS.: A retrospective cross-sectional study was conducted on the basis of medical records of 437 patients with clinical suspicion of ATL, registered in electronic hospital system between 1980 and 2013...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29166499/skin-disorders-in-renal-transplant-recipients-a-retrospective-study
#19
Pedro Miguel Clemente Garrido, João Borges-Costa
BACKGROUND: Immunosuppressive therapy, which is necessary to avoid graft rejection in renal transplant recipients, presents an increased risk of several pathologies, namely infectious and neoplastic. OBJECTIVES: To identify the most frequent skin diseases and their clinical and demographical risk factors within a population of renal transplant recipients. METHODS: A retrospective study of renal transplant recipients referred to dermatology visit and observed for the first time from January 2008 to December 2014...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29159004/linear-malignant-melanoma-in-situ-reports-and-review-of-cutaneous-malignancies-presenting-as-linear-skin-cancer
#20
Philip R Cohen
Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized in this report. A medical literature search engine, PubMed, was used to search the following terms: cancer, cutaneous, in situ, linear, malignant, malignant melanoma, melanoma in situ, neoplasm, and skin...
September 18, 2017: Curēus
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