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https://www.readbyqxmd.com/read/29467523/early-low-dose-hydrocortisone-is-the-neurodevelopment-affected
#1
Gaston Ofman, Marta Perez, Kathryn N Farrow
TYPE OF INVESTIGATION: Prognosis; exploratory secondary analysis of an interventional randomized controlled trial. QUESTION: In extremely preterm infant (<28 weeks), is early low-dose hydrocortisone compared to placebo associated with neurodevelopmental impairment at 2 years of age? METHODS: Patients: Surviving infants enrolled in the PREMILOC trial conducted in France between 2008 and 2014. INTERVENTION: Double-blind, multicenter, randomized, placebo-controlled trial of infants born between 24 0/7 weeks and 27 6/7 weeks of gestation and before 24 h of postnatal age, assigned to receive either placebo or low-dose hydrocortisone (0...
June 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29348196/placental-findings-and-effect-of-prophylactic-hydrocortisone-in-extremely-preterm-infants
#2
Alice Héneau, Fabien Guimiot, Damir Mohamed, Aline Rideau Batista Novais, Corinne Alberti, Olivier Baud
OBJECTIVES: To investigate the relationship between histologic findings of the placenta and response to early postnatal hydrocortisone treatment used to prevent bronchopulmonary dysplasia (BPD) in extremely preterm infants. METHODS: In an exploratory analysis of the Early Low-Dose Hydrocortisone to Improve Survival Without Bronchopulmonary Dysplasia in Extremely Preterm Infants (PREMILOC) trial, detailed placental analyses were performed on the basis of standardized macroscopic and histologic examinations...
February 2018: Pediatrics
https://www.readbyqxmd.com/read/29321180/two-year-neurodevelopmental-outcomes-of-extremely-preterm-infants-treated-with-early-hydrocortisone-treatment-effect-according-to-gestational-age-at-birth
#3
Olivier Baud, Clémence Trousson, Valérie Biran, Emilie Leroy, Damir Mohamed, Corinne Alberti
OBJECTIVE: To determine whether early hydrocortisone treatment in extremely preterm infants affects neurodevelopmental outcomes at 2 years of age according to gestational age at birth. PATIENTS AND METHODS: This is an exploratory analysis of neurodevelopmental outcomes by gestational age strata from the PREMILOC trial, in which patients were randomly assigned to receive either placebo or low-dose hydrocortisone and randomisation was stratified by gestational age groups (24-25 and 26-27 weeks of gestation)...
January 10, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28384828/association-between-early-low-dose-hydrocortisone-therapy-in-extremely-preterm-neonates-and-neurodevelopmental-outcomes-at-2-years-of-age
#4
RANDOMIZED CONTROLLED TRIAL
Olivier Baud, Clémence Trousson, Valérie Biran, Emilie Leroy, Damir Mohamed, Corinne Alberti
Importance: Dexamethasone to prevent bronchopulmonary dysplasia in very preterm neonates was associated with adverse neurodevelopmental events. Early low-dose hydrocortisone treatment has been reported to improve survival without bronchopulmonary dysplasia but its safety with regard to neurodevelopment remains to be assessed. Objective: To assess whether early hydrocortisone therapy in extremely preterm infants is associated with neurodevelopmental impairment at 2 years of age...
April 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26916176/effect-of-early-low-dose-hydrocortisone-on-survival-without-bronchopulmonary-dysplasia-in-extremely-preterm-infants-premiloc-a-double-blind-placebo-controlled-multicentre-randomised-trial
#5
RANDOMIZED CONTROLLED TRIAL
Olivier Baud, Laure Maury, Florence Lebail, Duksha Ramful, Fatima El Moussawi, Claire Nicaise, Véronique Zupan-Simunek, Anne Coursol, Alain Beuchée, Pascal Bolot, Pierre Andrini, Damir Mohamed, Corinne Alberti
BACKGROUND: Bronchopulmonary dysplasia, a major complication of extreme prematurity, has few treatment options. Postnatal steroid use is controversial, but low-dose hydrocortisone might prevent the harmful effects of inflammation on the developing lung. In this study, we aimed to assess whether low-dose hydrocortisone improved survival without bronchopulmonary dysplasia in extremely preterm infants. METHODS: In this double-blind, placebo-controlled, randomised trial done at 21 French tertiary-care neonatal intensive care units (NICUs), we randomly assigned (1:1), via a secure study website, extremely preterm infants inborn (born in a maternity ward at the same site as the NICU) at less than 28 weeks of gestation to receive either intravenous low-dose hydrocortisone or placebo during the first 10 postnatal days...
April 30, 2016: Lancet
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