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https://www.readbyqxmd.com/read/29141384/-problems-deserving-attention-in-preventing-infection-in-cataract-surgery
#1
J Ye
Endophthalmitis is one of the most serious complications of cataract surgery. The surgeons try to reduce the incidence of endophthalmitis. In order to prevent postoperative infection, irrigation of the conjunctival sac with povidone iodine and injection of antibiotics into the anterior chamber before the end of the surgery are used. Although there are a lot of reports about the concentration, mode and duration of povidone iodine application, there is no consensus. There are many options for antibiotics, including cefuroxime, vancomycin and moxifloxacin...
November 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29141352/-overdiagnosis-in-mammography-screening-for-breast-cancer
#2
Y B Huang, L Yang, F J Song, K X Chen
Screening has been always considered as a double-edged sword. Cancer screening could save lives in some cases, however, in other cases, it might also turn people into overdiagnosis. Overdiagnosis is the diagnosis of cancer that will never cause symptoms or death during a patient's lifetime. Therefore, overdiagnosis might lead to unnecessary treatments and lifetime surveillance, and then increase economic burden and psychological burden. In this review, we focus on how to correctly evaluate the overdiagnosis rate, and how to avoid or reduce the harms caused by overdiagnosis in the future according to the reasons associated with overdiagnosis...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29138586/association-between-metabolic-syndrome-and-sensorineural-hearing-loss-a-cross-sectional-study-of-11-114-participants
#3
Javad Aghazadeh-Attari, Behnam Mansorian, Mohammad Mirza-Aghazadeh-Attari, Jamal Ahmadzadeh, Iraj Mohebbi
Background/objectives: Hearing loss (HL) is associated with certain diseases and affects health, resulting in a low quality of life. Some components of the metabolic syndrome (MetS) coincide with the risk factors for sensorineural hearing loss (SNHL). To date, very few studies have examined the link between MetS and HL. The aim of the current study was to try to understand the potential association between MetS and HL. Methods: Using Iranian health surveys of professional drivers, we enrolled 11,114 individuals aged 20-60 years, whose main job is to operate a motor vehicle...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29137922/extracellular-vesicles-in-neurodegenerative-diseases
#4
REVIEW
Tommaso Croese, Roberto Furlan
Extracellular vesicles (EVs) are released by all neural cells, including neurons, oligodendrocytes, astrocytes, and microglia. The lack of adequate technology has not halted neuroscientists from investigating EVs as a mean to decipher neurodegenerative disorders, still in search of comprehensible pathogenic mechanisms and efficient treatment. EVs are thought to be one of ways neurodegenerative pathologies spread in the brain, but also one of the ways the brain tries to displace toxic proteins, making their meaning in pathogenesis uncertain...
November 11, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29137720/improving-surgical-residents-communication-in-disclosing-complications-a-qualitative-analysis-of-simulated-physician-and-patient-surrogate-conversations
#5
Carolina Fernandez Branson, Jeffrey G Chipman
BACKGROUND: In this study, we explore surgical resident communication with simulated patient surrogates (SPs), in an Objective Structured Clinical Examination (OSCE). METHODS: We use discourse analysis (DA), a qualitative approach to analyzing language, to evaluate our residents' interactions with simulated patient surrogates. After identifying problematic communication patterns, we apply communication theory to discuss our findings and provide suggestions for improvement...
November 7, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29136546/multi-component-hybrid-soft-ionogels-for-photoluminescence-tuning-and-sensing-organic-solvent-vapors
#6
Jing Ma, Bing Yan
This paper tries to prepare soft ionogels through the carboxyl ion liquid (IM(+)Br(-)) as double chemical linker connecting both Bio-MOF-1 (Zn8(ad)4(BPDC)6O·2Me2NH2, BPDC=biphenyl-4,4'-dicarboxylate, Ad = adeninate) and lanthanide complexes. Among anionic Bio-MOF-1 interacts with IM(+)Br(-) through cation exchange (IM(+)) to form BMOF-IM and lanthanide ions are further introduced through the coordination to the carboxylic group of IM(+) together with Phen (1,10-phenanthroline) as assistant ligand for Ln(3+) (Ln = Eu, Tb or Eu/Tb)...
November 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29136271/emergency-preparedness-training-preferences-and-perceived-barriers-to-training-among-various-healthcare-providers-and-public-health-practitioners-in-massachusetts
#7
John Broach, Mary-Elise Smith
INTRODUCTION: Emergency preparedness training is vital to a wide range of healthcare and public health disciplines. Although agencies may try to tailor their training efforts based on perceived need, the topics and methods of instruction may be misguided, resulting in wasted effort and poor participation in training events. OBJECTIVE: The objective of this study was to understand in a rigorous way, the training preferences and barriers to training among practitioners in Massachusetts...
April 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/29134824/an-overview-of-the-role-of-carfilzomib-in-the-treatment-of-multiple-myeloma
#8
Dimitrios C Ziogas, Evangelos Terpos, Efstathios Kastritis, Meletios A Dimopoulos
Carfilzomib is a second-generation proteasome inhibitor that binds selectively and irreversibly with the chymotrypsin-like site of the proteolytic core. Its initial approval by the Food and Drug Administration, as monotherapy for relapsed/refractory multiple myeloma (RR-MM), followed soon by a global authorization of its combination with dexamethasone or with lenalidomide plus dexamethasone for the treatment of RR-MM after 1-3 prior lines. In order to optimize its administration, carfilzomib is currently examined in different doses and regimens in relapsed/refractory as well as in newly diagnosed myeloma...
November 14, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29134620/pre-residency-publication-and-its-association-with-paediatric-residency-match-outcome-a%C3%A2-retrospective-analysis-of-a%C3%A2-national-database
#9
Ronish Gupta, Mark L Norris, Nicholas Barrowman, Hilary Writer
INTRODUCTION: Scholarly activity is considered valuable in the resident selection process by candidates and program directors alike, despite existing literature suggesting applicants with scholarly work do not perform better in the match. These studies, however, are limited in that they have only measured whether candidates have successfully matched or not. To try and reconcile the existing disconnect in the value of pre-residency scholarly activity, we sought to deepen the understanding by investigating whether pre-residency publication is associated with a higher rank-order list match achievement...
November 13, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/29133329/involvement-of-people-with-dementia-in-making-decisions-about-their-lives-a-qualitative-study-that-appraises-shared-decision-making-concerning-daycare
#10
Leontine Groen-van de Ven, Carolien Smits, Fuusje de Graaff, Marijke Span, Jan Eefsting, Jan Jukema, Myrra Vernooij-Dassen
OBJECTIVE: To explore how people with dementia, their informal caregivers and their professionals participate in decision making about daycare and to develop a typology of participation trajectories. DESIGN: A qualitative study with a prospective, multiperspective design, based on 244 semistructured interviews, conducted during three interview rounds over the course of a year. Analysis was by means of content analysis and typology construction. SETTING: Community settings and nursing homes in the Netherlands...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29132633/the-use-of-online-forums-by-people-living-with-hiv-for-help-in-understanding-personal-health-information
#11
Adrian Bussone, Simone Stumpf, Stephanie Wilson
PURPOSE: Effective self-management of the human immunodeficiency virus/acquired immune deficiency virus (HIV/AIDS) requires constant vigilance over personal health information. Little is known about the contribution of online communities to this endeavour. This paper reports a study to investigate how people living with HIV/AIDS use an online community to try to understand their personal health information by analysing how health information is shared and asked about, and how the community responds to questions...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29131779/sport-sampling-is-associated-with-improved-landing-technique-in-youth-athletes
#12
Lindsay J DiStefano, Eleanor M Beltz, Hayley J Root, Jessica C Martinez, Andrew Houghton, Nicole Taranto, Katherine Pearce, Erin McConnell, Courtney Muscat, Steve Boyle, Thomas H Trojian
BACKGROUND: Sport sampling is recommended to promote fundamental movement skill acquisition and physical activity. In contrast, sport specialization is associated with musculoskeletal injury risk, burnout, and attrition from sport. There is limited evidence to support the influence of sport sampling on neuromuscular control, which is associated with injury risk, in youth athletes. HYPOTHESIS: Athletes who participated in only 1 sport during the previous year would demonstrate higher Landing Error Scoring System (LESS) scores than their counterparts...
November 1, 2017: Sports Health
https://www.readbyqxmd.com/read/29131292/in-hospital-sudden-cardiac-arrest-protocol-analysis
#13
Adrianna Jagosz, Dominika Bursy, Aneta Sobon, Pawel Kiczmer, Maja Copik, Szymon Bialka, Jacek Smereka, Hanna Misiolek, Łukasz Szarpak
BACKGROUND: In-hospital sudden cardiac arrest (SCA) is an event that is linked to high mortality. Data analysis of SCA and the course of in-hospital cardiopulmonary resuscitation (CPR) allows for its better understanding and improvement. AIM: Analysis of cases of SCA and the procedures taken by the medical staff of University Hospital. METHODS: A retrospective analysis of 104 protocols of SCA, from May 2014 to December 2015. Actions taken by medical staff before the arrival of the resuscitation team (RT) and RT proceedings...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29130894/a-comparison-of-the-role-of-beamwidth-in-biological-and-engineered-sonar
#14
Bryan Donald Todd, Rolf Mueller
Sonar is an important sensory modality for engineers as well as in nature. In engineering, sonar is the dominating modality for underwater sensing. In nature, biosonar is likely to have been a central factor behind the unprecedented evolutionary success of bats, a highly diverse group that accounts for over 20% of all mammal species. However, it remains unclear to what extent engineered and biosonar follow similar design and operational principles. In the current work, the key sonar design characteristic of beamwidth is examined in technical and biosonar...
November 13, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29130298/role-of-micrornas-mirnas-in-pathophysiology-of-diabetes-mellitus
#15
Juhi Tiwari, Gaurav Gupta, Terezinha de Jesus Andreoli Pinto, Rahul Sharma, Kavita Pabreja, Yogesh Matta, Neha Arora, Anurag Mishra, Rakesh Sharma, Kamal Dua
Diabetes Mellitus is becoming the critical problem among the entire world and it is difficult to understand the molecular mechanism representing the concept of diabetic pathology. Recently the knowledge of the involvement of genetics in type 2 diabetes mellitus (T2DM) susceptibility has sketched a great concentration towards the transcriptional activity of ß cells within the pancreas. This disease becomes the leading cause of death so it is necessary to study the molecular pathogenesis, phenotypes, and characteristics to design the therapeutic parameters...
November 10, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/29129969/statistical-contributions-to-bioinformatics-design-modeling-structure-learning-and-integration
#16
Jeffrey S Morris, Veerabhadran Baladandayuthapani
The advent of high-throughput multi-platform genomics technologies providing whole-genome molecular summaries of biological samples has revolutionalized biomedical research. These technologiees yield highly structured big data, whose analysis poses significant quantitative challenges. The field of Bioinformatics has emerged to deal with these challenges, and is comprised of many quantitative and biological scientists working together to effectively process these data and extract the treasure trove of information they contain...
2017: Statistical Modelling
https://www.readbyqxmd.com/read/29129049/dna-origami-directed-au-nanostar-dimers-for-single-molecule-surface-enhanced-raman-scattering
#17
Swati Tanwar, Krishna Haldar, Tapasi Sen
We demonstrate the synthesis of Au nanostar dimer with tunable interparticle gap and controlled stoichiometry as-sembled on DNA origami. Au nanostars with uniform and sharp tips were immobilized on rectangular DNA origami dimerized structures to create nanoantennas containing monomeric and dimeric Au nanostars. Single Texas red dye was specifically attached in the junction of the dimerized origami which acts as a Raman reporter molecule. The SERS enhancement factors of single Texas red dye located in the conjunction region in the dimer structures having inter-particle gaps of 7 nm and 13 nm are 2 × 1010 and 8 × 109, respectively, which are strong enough for single analyte detec-tion...
November 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29127786/development-and-initial-testing-of-the-brief-adolescent-smoking-curiosity-scale-ascos
#18
Georges E Khalil, Karen S Calabro, Alexander V Prokhorov
BACKGROUND: Although the reasons behind tobacco smoking at young age are complex, research has identified curiosity as a potent driver of smoking among adolescents. OBJECTIVE: The objective of the current study is to develop and provide initial evidence of reliability and validity of a short scale assessing smoking curiosity among adolescents (first measure of its kind). In particular, we developed and tested the adolescent smoking curiosity scale (ASCOS). METHODS: After scale development, 101 adolescents completed a survey on smoking-related measures, including ASCOS (June to August 2014)...
November 7, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29126390/reference-guided-de-novo-assembly-approach-improves-genome-reconstruction-for-related-species
#19
Heidi E L Lischer, Kentaro K Shimizu
BACKGROUND: The development of next-generation sequencing has made it possible to sequence whole genomes at a relatively low cost. However, de novo genome assemblies remain challenging due to short read length, missing data, repetitive regions, polymorphisms and sequencing errors. As more and more genomes are sequenced, reference-guided assembly approaches can be used to assist the assembly process. However, previous methods mostly focused on the assembly of other genotypes within the same species...
November 10, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29126298/what-proportion-of-people-who-try-one-cigarette-become-daily-smokers-a-meta-analysis-of-representative-surveys
#20
Max Birge, Stephen Duffy, Joanna Astrid Miler, Peter Hajek
Introduction: The 'conversion rate' from initial experimentation to daily smoking is a potentially important metric of smoking behavior, but estimates of it based on current representative data are lacking. Methods: The Global Health Data Exchange was searched for representative surveys conducted in English speaking, developed countries after year 2000 that included questions about ever trying a cigarette and ever smoking daily. The initial search identified 2776 surveys that were further screened for language, location, year, sample size, survey structure and representativeness...
November 4, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
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