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https://www.readbyqxmd.com/read/28087381/prevalence-risk-factors-and-clinical-outcomes-of-atopic-and-nonatopic-asthma-among-rural-children
#1
Joshua A Lawson, Luan M Chu, Donna C Rennie, Louise Hagel, Chandima P Karunanayake, Punam Pahwa, James A Dosman
BACKGROUND: Because of time and cost constraints, objective classification of atopic and nonatopic asthma has been limited in large epidemiologic studies. However, as we try to better understand exposure-outcome associations and ensure appropriate treatment of asthma, it is important to focus on phenotype-defined asthma classification. OBJECTIVE: To compare atopic and nonatopic asthma in rural children with regard to risk factors and clinical outcomes. METHODS: We conducted a cross-sectional study in rural Saskatchewan, Canada, in 2011...
January 10, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28080089/what-you-like-is-what-you-try-to-get-attitudes-toward-emotions-and-situation-selection
#2
Noam Markovitch, Liat Netzer, Maya Tamir
Why do people expose themselves to certain emotional stimuli and avoid others? We propose that what people want to feel is linked to attitudes toward emotions. In 3 studies, we show that individuals with more (vs. less) negative attitudes toward an emotion were more (vs. less) likely to avoid stimuli that induce that emotion. People who evaluated disgust (or joy) less favorably than others were less likely to expose themselves to disgusting (or joyful) pictures (Study 1). These links were emotion-specific and could not be explained by differences in state or trait emotion (Study 2) or in emotional reactivity (Study 3)...
January 12, 2017: Emotion
https://www.readbyqxmd.com/read/28079838/re-it-may-be-too-early-to-try-to-prove-the-effect-of-deworming-on-tuberculin-reactivity
#3
Marieke M Van der Zalm, Nelda van Soelen, Anna M Mandalakas, Marc Jacobsen, Anne K Detjen, Florian M Marx, Harleen M S Grewal, Mark F Cotton, Gerhard Walzl, Anneke C Hesseling
No abstract text is available yet for this article.
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28079837/it-may-be-too-early-to-try-to-prove-the-effect-of-deworming-on-tuberculin-reactivity
#4
Roi Piñeiro Pérez, Talia Sáinz-Costa, María José Mellado-Peña
No abstract text is available yet for this article.
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28077906/how-to-improve-visibility-of-scientific-biomedical-sources
#5
REVIEW
Asim Kurjak
With the rapid development of information and communications technologies, industrial nations are transforming into societies in which knowledge is the most contested and valuable good. The increased speed at which we have to acquire new knowledge, insights, and abilities is forcing us to divide up learning into novel, shorter phases. The traditional choreography of learning with its long, rigid defined school, job, and university educational periods is already obsolete today. Self-organized, lifelong learning is becoming a must...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28076468/phenotypic-diversity-and-selection-maintain-leishmania-amazonensis-infectivity-in-balb-c-mouse-model
#6
Benoît Espiau, Virginia Vilhena, Armelle Cuvillier, Aldina Barral, Gilles Merlin
Leishmania are protozoan parasites that show remarkable diversity, as revealed by the various clinical forms of leishmaniasis, which can range from mild skin lesions to severe metastatic cutaneous/mucosal lesions. The exact nature and extent of Leishmania phenotypic diversity in establishing infection is not fully understood. In order to try to understand some aspects of this diversity, we subcutaneously infected BALB/c mice with first and second generation subclones of a L. amazonensis strain isolated from a patient (BA125) and examined in vivo lesion growth rate and antimony susceptibility...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28076302/detecting-paraprotein-interference-on-a-direct-bilirubin-assay-by-reviewing-the-photometric-reaction-data
#7
Elena García-González, Maite Aramendía, Ricardo González-Tarancón, Naiara Romero-Sánchez, Luis Rello
BACKGROUND: The direct bilirubin (D-Bil) assay on the AU Beckman Coulter instrumentation can be interfered by paraproteins, which may result in spurious D-Bil results. In a previous work, we took advantage of this fact to detect this interference, thus helping with the identification of patients with unsuspected monoclonal gammopathies. In this work, we investigate the possibility to detect interference based on the review of the photometric reactions, regardless of the D-Bil result. METHODS: The D-Bil assay was carried out in a set of 2164 samples...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28074583/show-code
#8
Daniel Shalev
"Let's get one thing straight: there is no such thing as a show code," my attending asserted, pausing for effect. "You either try to resuscitate, or you don't. None of this halfway junk." He spoke so loudly that the two off-service consultants huddled at computers at the end of the unit looked up… We did four rounds of compressions and pushed epinephrine twice. It was not a long code. We did good, strong compressions and coded this man in earnest until the end. Toward the final round, though, as I stepped up to do compressions, my attending looked at me in a deep way...
January 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28072987/-a-pilot-clinical-study-of-immediate-provisionalization-with-a-chairside-computer-aided-design-and-computer-aided-manufacture-monolithic-crown-for-single-tooth-immediate-implant-placement
#9
J H Tian, P Di, Y Lin, Y Zhang, D H Wei, H Y Cui
Objective: To evaluate the primary clinical outcomes of immediate provisionalization with a monolithic crown utilizing a novel chairside computer aided design and computer aided manufacture (CAD/CAM) workflow for single tooth immediate implant placement. Methods: This pilot study was a prospective within-subjects design. Thirteen consecutive patients were included and diagnosed with untreatable single incisor or premolar with fine general and local anatomical conditions. The trial was conducted at Department of Implantology, Peking University School and Hospital of Stomatology, Beijing, between January 2016 and June 2016...
January 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28071872/mutant-botrocetin-2-inhibits-von-willebrand-factor-induced-platelet-agglutination
#10
T Matsui, A Hori, J Hamako, F Matsushita, Y Ozeki, Y Sakurai, M Hayakawa, M Matsumoto, Y Fujimura
BACKGROUND: Botrocetin-2 (Bot2) is a botrocetin-like protein composed of α and β subunits that have been cloned from the snake Bothrops jararaca. Bot2 binds specifically to von Willebrand factor (VWF), and the complex induces glycoprotein (GP) Ib-dependent platelet agglutination. OBJECTIVES: We exploited Bot2's VWF-binding capacity to try and create a mutant Bot2 that binds to VWF but inhibits platelet agglutination. METHODS AND RESULTS: Several point mutations were introduced into Bot2 cDNA, and the recombinant protein (rBot2) was purified on an anti-botrocetin column...
January 10, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28070790/brief-report-mealtime-behaviors-of-chinese-american-children-with-autism-spectrum-disorder
#11
Heewon Lee Gray, Hsu-Min Chiang
This study investigated mealtime behaviors of Chinese-American children with autism spectrum disorder (ASD). Thirty-one parents of Chinese-American children with ASD participated in this study and the Brief Autism Mealtime Behavior Inventory (BAMBI) was used. The top problematic mealtime behaviors reported by parents were prefers "crunchy" food (54.2%); not willing to try new foods (48%); and does not remain seated at the table until the meal is finished (46%). This study found that the majority of the Chinese-American children with ASD seldom or never were aggressive (96%) or disruptive during mealtimes (92...
January 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28070754/pow-boom-kablam-effects-of-viewing-superhero-programs-on-aggressive-prosocial-and-defending-behaviors-in-preschool-children
#12
Sarah M Coyne, Laura Stockdale, Jennifer Ruh Linder, David A Nelson, Kevin M Collier, Lee W Essig
Many schools and parents try to motivate children to become defenders of victimized peers. Defending behavior is common in the media (particularly in superhero programs); however, no study has examined the effect of media on defending behavior. The aim of the study was to examine longitudinal associations between superhero engagement and a variety of aggressive, prosocial, and defending behaviors in preschool children. Participants consisted of 240 preschoolers (49% male) and their parents who reported on child media use and outcomes at 2 different time points...
January 9, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28070620/nicotine-delivery-to-users-from-cigarettes-and-from-different-types-of-e-cigarettes
#13
Peter Hajek, Dunja Przulj, Anna Phillips, Rebecca Anderson, Hayden McRobbie
BACKGROUND: Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS: Twelve participants ('dual users' of EC and cigarettes) used their own brand cigarette and nine different EC brands. Blood samples were taken at baseline and at 2-min intervals for 10 min and again at 30 min. RESULTS: Eleven smokers provided usable data...
January 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28069021/preoperative-optimization-of-patient-expectations-improves-long-term-outcome-in-heart-surgery-patients-results-of-the-randomized-controlled-psy-heart-trial
#14
Winfried Rief, Meike C Shedden-Mora, Johannes A C Laferton, Charlotte Auer, Keith J Petrie, Stefan Salzmann, Manfred Schedlowski, Rainer Moosdorf
BACKGROUND: Placebo effects contribute substantially to outcome in most fields of medicine. While clinical trials typically try to control or minimize these effects, the potential of placebo mechanisms to improve outcome is rarely used. Patient expectations about treatment efficacy and outcome are major mechanisms that contribute to these placebo effects. We aimed to optimize these expectations to improve outcome in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS: In a prospective three-arm randomized clinical trial with a 6 month follow-up, 124 patients scheduled for CABG surgery were randomized to either a brief psychological pre-surgery intervention to optimize outcome expectations (EXPECT); or a psychological control intervention focusing on emotional support and general advice, but not on expectations (SUPPORT); or to standard medical care (SMC)...
January 10, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28067941/preliminary-considerations-about-the-presence-of-aedes-albopictus-skuse-1897-diptera-culicidae-during-winter-in-the-northwestern-italy
#15
M Dutto, A Mosca
Aedes albopictus, the Asian tiger mosquito, was unintentionally introduced in Italy at the beginning of the 1990s. In few decades it spread almost in the whole Country. In Piedmont, the first report dates back to 1994. Usually, temperate populations are affected by seasonal temperature and photoperiodicity and can overwinter by producing eggs that undergo a winter diapause. In Rome females of the species extended their trophic activity to the coldest months of the year, but there is no notice about a similar behaviour for northern areas of the Country...
January 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28067829/the-cause-of-death-of-a-child-in-the-18th-century-solved-by-bone-microbiome-typing-using-laser-microdissection-and-next-generation-sequencing
#16
Valeria D'Argenio, Marielva Torino, Vincenza Precone, Giorgio Casaburi, Maria Valeria Esposito, Laura Iaffaldano, Umberto Malapelle, Giancarlo Troncone, Iolanda Coto, Paolina Cavalcanti, Gaetano De Rosa, Francesco Salvatore, Lucia Sacchetti
The history of medicine abounds in cases of mysterious deaths, especially by infectious diseases, which were probably unresolved because of the lack of knowledge and of appropriate technology. The aim of this study was to exploit contemporary technologies to try to identify the cause of death of a young boy who died from a putative "infection" at the end of the 18th century, and for whom an extraordinarily well-preserved minute bone fragment was available. After confirming the nature of the sample, we used laser microdissection to select the most "informative" area to be examined...
January 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28067773/a-systems-biological-view-of-life-and-death-decision-with-respect-to-endoplasmic-reticulum-stress-the-role-of-perk-pathway
#17
Margita Márton, Anita Kurucz, Beáta Lizák, Éva Margittai, Gábor Bánhegyi, Orsolya Kapuy
Accumulation of misfolded/unfolded proteins in the endoplasmic reticulum (ER) leads to the activation of three branches (Protein kinase (RNA)-like endoplasmic reticulum kinase [PERK], Inositol requiring protein 1 [IRE-1] and Activating trascription factor 6 [ATF6], respectively) of unfolded protein response (UPR). The primary role of UPR is to try to drive back the system to the former or a new homeostatic state by self-eating dependent autophagy, while excessive level of ER stress results in apoptotic cell death...
January 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28063052/monitoring-of-chemically-induced-colitis
#18
Sonja Reißig, Benno Weigmann
Inflammation is a common symptom of inflammatory bowel disease (IBD). Actually, many experimental models of colitis exist and try to mimic the human situation in order to understand the pathogenesis of Crohn's disease and ulcerative colitis. These experimental models of inflammation can be characterized by specific parameters, which illustrate the proceeding inflammatory process. By use of these models potentially new reagents for improved therapeutic approaches can be analyzed. Here, we describe the TNBS-mediated colitis model and specify different parameters for the detailed characterization of the inflammatory process in experimental colitis models...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28062500/translational-relevance-and-recent-advances-of-animal-models-of-abdominal-aortic-aneurysm
#19
Jean Senemaud, Giuseppina Caligiuri, Harry Etienne, Sandrine Delbosc, Jean-Baptiste Michel, Raphaël Coscas
Human abdominal aortic aneurysm (AAA) pathophysiology is not yet completely understood. In conductance arteries, the insoluble extracellular matrix, synthesized by vascular smooth muscle cells, assumes the function of withstanding the intraluminal arterial blood pressure. Progressive loss of this function through extracellular matrix proteolysis is a main feature of AAAs. As most patients are now treated via endovascular approaches, surgical AAA specimens have become rare. Animal models provide valuable complementary insights into AAA pathophysiology...
January 5, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28061915/prevalence-predictors-and-prevention-of-motion-sickness-in-zero-g-parabolic-flights
#20
John F Golding, Aurore C Paillard, Hervé Normand, Stéphane Besnard, Pierre Denise
INTRODUCTION: Zero-G parabolic flight reproduces the weightlessness of space for short periods. However, motion sickness may affect some fliers. The aim was to assess the extent of this problem and to find possible predictors and modifying factors. METHODS: Airbus zero-G flights consist of 31 parabolas performed in blocks. Each parabola consisted of 20 s of 0 g sandwiched by 20 s of hypergravity of 1.5-1.8 g. The survey covered N = 246 person-flights (193 men, 53 women), ages (M ± SD) 36...
January 1, 2017: Aerospace Medicine and Human Performance
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