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https://www.readbyqxmd.com/read/29341876/probing-and-characterizing-the-high-specific-sequences-of-ssdna-aptamer-against-sgiv-infected-cells
#1
Pengfei Li, Qing Yu, Lingli Zhou, Dexin Dong, Shina Wei, Hanzheng Ya, Bo Chen, Qiwei Qin
As the major viral pathogen of grouper aquaculture, Singapore grouper iridovirus (SGIV) has caused great economic losses in China and Southeast Asia. In the previous study, we have generated highly specific ssDNA aptamers against SGIV-infected grouper spleen cells (GS) by Systematic Evolution of Ligands by Exponential Enrichment technology (SELEX), in which Q2 had the highest binding affinity of 16.43 nM. In this study, we would try to identify the specific sequences in the aptamer Q2 that exhibited the high binding affinity to SGIV-infected cells by truncating the original Q2 into some different specific segments...
January 13, 2018: Virus Research
https://www.readbyqxmd.com/read/29341751/entanglement-in-nonunitary-quantum-critical-spin-chains
#2
Romain Couvreur, Jesper Lykke Jacobsen, Hubert Saleur
Entanglement entropy has proven invaluable to our understanding of quantum criticality. It is natural to try to extend the concept to "nonunitary quantum mechanics," which has seen growing interest from areas as diverse as open quantum systems, noninteracting electronic disordered systems, or nonunitary conformal field theory (CFT). We propose and investigate such an extension here, by focusing on the case of one-dimensional quantum group symmetric or supergroup symmetric spin chains. We show that the consideration of left and right eigenstates combined with appropriate definitions of the trace leads to a natural definition of Rényi entropies in a large variety of models...
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341524/-what-s-new-in-ambulatory-general-internal-medicine%C3%A2
#3
Annick Gerber, Camille Buffle Genecand, Thierry Mach, David Schrumpf, Ana Rita Forte Marques, Jean Dupraz, Thomas Schmid
Many treatments are used every day in general medicine without any evidence of their efficacy. This last year, three randomised studies tried to prove the clinical utility of chondroitin/glucosamine in arthritis, cranberry in urinary infections, and acupuncture in migraine. Screening and management of prostate cancer are still controversial. Two recent studies help us advising our patients on this difficult topic. Muscle side effects from statins are well known and have been widely relayed by the press these last years, although myopathies are rare in clinical trials...
January 17, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29338076/hypoxia-inducible-transcription-factors-hif1a-and-hif2a-increase-in-aging-mucosal-tissues
#4
J L Ebersole, M J Novak, L Orraca, J Martinez-Gonzalez, S Kirakodu, K C Chen, A Stromberg, O A Gonzalez
Hypoxia (ie. oxygen deprivation) activates the hypoxia-signaling pathway, primarily via hypoxia inducible transcription factors (HIF) for numerous target genes, which mediate angiogenesis, metabolism, coagulation, among other processes to try to replenish tissues with blood and oxygen. Hypoxia signaling dysregulation also commonly occurs during chronic inflammation. We sampled gingival tissues from rhesus monkeys (M. mulatta; 3-25 years old) and total RNA was isolated for microarray analysis. HIF1A, HIF1B, and HIF2A were significantly different in healthy aged tissues, and both HIF1A and HIF3A were positively correlated with aging...
January 16, 2018: Immunology
https://www.readbyqxmd.com/read/29337794/noninvasive-treatment-of-hypoxemic-respiratory-failure-give-it-a-try%C3%A2-but-do-not-push-too-hard
#5
Jean-Christophe Richard
No abstract text is available yet for this article.
February 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29337129/effect-of-amino-acid-substitution-of-caprice-on-cell-to-cell-movement-ability-in-arabidopsis-root-epidermis
#6
Rumi Tominaga-Wada, Takuji Wada
An R3-type MYB transcription factor, CAPRICE (CPC), is known to promote root hair cell differentiation in Arabidopsis root epidermis. The CPC protein moves from non-hair cells to the neighboring cells, and acts as an inducer of root hair formation. In contrast, we previously showed that the CPC homolog, ENHANCER OF TRY AND CPC1 (ETC1), does not move between the root epidermal cells. To clarify the critical difference in the cell-to-cell movement ability of CPC and ETC1 proteins, we generated five different chimeras of CPC and ETC1...
January 11, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29333730/day-to-day-mastery-and-self-efficacy-changes-during-a-smoking-quit-attempt-two-studies
#7
Lisa M Warner, Gertraud Stadler, Janina Lüscher, Nina Knoll, Sibylle Ochsner, Rainer Hornung, Urte Scholz
OBJECTIVE: In social-cognitive theory, it is hypothesized that mastery experiences (successfully implementing behaviour change) are a source of self-efficacy, and self-efficacy increases the opportunity for experiencing mastery. Vicarious experiences (seeing others succeed) are suggested as another source of self-efficacy. However, the hypothesis of this reciprocal relationship has not been tested using a day-to-day design. DESIGN: This article reports findings from two intensive longitudinal studies, testing the reciprocal relationship of self-efficacy and its two main sources within the naturally occurring process of quitting smoking (without intervention)...
January 15, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29333500/improving-the-written-medical-handover
#8
Rhys Martin, Melanie Huddart, Cara Garbett, Wendell Storr, Olivia Watts, Sanjeev Gupta
The handover of large numbers of medical patients, during on call periods when staffing levels are reduced, is a challenge for all acute medical services. At the Royal Cornwall Hospital, a large district general hospital, we identified that foundation doctors were reviewing medical inpatients during weekend on call periods with limited written handover information. We chose to address this problem by developing an intervention, a weekend handover sticker, and piloting it. We used the review of documentation to measure improvement and feedback from users to assess the processes involved...
2018: BMJ Open Quality
https://www.readbyqxmd.com/read/29331642/protein-adaptations-in-extremophiles-an-insight-into-extremophilic-connection-of-mycobacterial-proteome
#9
REVIEW
Ashutosh Kumar, Anwar Alam, Deeksha Tripathi, Mamta Rani, Hafeeza Khatoon, Saurabh Pandey, Nasreen Z Ehtesham, Seyed E Hasnain
The biological paradox about how extremophiles persist at extreme ecological conditions throws a fascinating picture of the enormous potential of a single cell to adapt to homeostatic conditions in order to propagate. Unicellular organisms face challenges from both environmental factors and the ecological niche provided by the host tissue. Although the existence of extremophiles and their physiological properties were known for a long time, availability of whole genome sequence has catapulted the study on mechanisms of adaptation and the underlying principles that have enabled these unique organisms to withstand evolutionary and environmental pressures...
January 10, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29329812/synergistic-effect-of-polysaccharides-betalain-pigment-and-phenolic-compounds-of-red-prickly-pear-opuntia-stricta-in-the-stabilization-of-salami
#10
Nadia Kharrat, Hedia Salem, Aicha Mrabet, Fatma Aloui, Soumaya Triki, Ahmed Fendri, Youssef Gargouri
The aim of this work is to try to substitute some synthetic additives by a natural extract from red prickly pear (Opuntia stricta) which known by its richness on bioactive polysaccharides mainly consisting of galactose, rhamnose and galacturonic acid. This natural fruit has a high content of carbohydrates above 18.81% FM. It contains also a high level of polyphenols 152.25 ± 0.26 μg QE/mg PPE and flavonoids about 370.60 ± 0.12 μg GAE/mg of PPE. In addition, prickly pear extract (PPE) displayed a strong antioxidant and antimicrobial activities...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29328780/risk-factors-for-depression-an-autobiographical-review
#11
Constance Hammen
I have been given a priceless opportunity to reflect on my career in the remarkably productive field of risk factors for depression. Psychological research on depression exploded in the early years of my work. I try to give an account of the choices and challenges, and reflect on the influences, some calculated and some serendipitous, that determined the paths I have followed. I focus mostly on the robust depression risk factors that have influenced my research, including dysfunctional cognitions, stressful life events and circumstances, parental depression, interpersonal dysfunction, and being female, and I cover some of what I did but also the influential work of others...
January 12, 2018: Annual Review of Clinical Psychology
https://www.readbyqxmd.com/read/29326986/measles-virus-background-and-oncolytic-virotherapy
#12
REVIEW
Sankhajit Bhattacharjee, Pramod Kumar Yadava
Measles is a highly transmissible disease caused by measles virus and remains a major cause of child mortality in developing countries. Measles virus nucleoprotein (N) encapsidates the RNA genome of the virus for providing protection from host cell endonucleases and for specific recognition of viral RNA as template for transcription and replication. This protein is over-expressed at the time of viral replication. The C-terminal of N protein is intrinsically disordered, which enables this protein to interact with several host cell proteins...
March 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29326506/the-bond-strength-of-nanohybrid-and-nanoceramic-composites-to-feldspathic-porcelain
#13
Hatice Özdemir, Nuran Dinçkal Yanikoglu
Background: Porcelain fracture is the most important problem in fixed prosthetic restorations. The replacement of fractured restoraions isn't often prefer by patients and dentists. Intraoral repair of fractured porcelain is a big alternative for patient and dentist. For this reason, dentists try to improve different surface treatments to increase the bond strength between porcelain and repair materials such as composite resins. Aims: The aim of this study was to evaluate the shear bond strength (SBS) of nano-hybrid (Nh...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29324295/analytical-determination-of-the-reducing-and-stabilization-agents-present-in-different-zostera-noltii-extracts-used-for-the-biosynthesis-of-gold-nanoparticles
#14
Rafael Zarzuela, Manuel Jesús Luna, María Luisa Almoraima Gil, María Jesús Ortega, José María Palacios-Santander, Ignacio Naranjo-Rodríguez, Juan José Delgado, Laura María Cubillana-Aguilera
The objective of this work was to ascertain the nature of the components responsible for the reducing and stabilizing properties of Zostera noltii extracts that lead to gold nanoparticle formation using chemical techniques of analysis. In order to achieve this aim, we try the synthesis of AuNPs with three different extracts from plants collected in the Bay of Cádiz (Spain). The n-butanol extract produced the best results. Taking this into account, four fractions were isolated by Sephadex LH-20 column chromatography from this extract and we studied their activity...
December 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29323625/catheter-associated-urinary-tract-infections-in-persons-with-neurogenic-bladders
#15
Todd A Linsenmeyer
This review is based on the author's Donald Munro Lecture given at the annual conference of the Academy of Spinal Cord Injury Professionals in New Orleans, LA. Indwelling catheters play an important role in bladder management following SCI for many individuals with neurogenic bladders. There is an increased risk of UTI compared to other types of bladder management with indwelling urethral catheters but not SP catheters. To minimize the risk of symptomatic UTI, the following steps are essential: prevent bladder wall distention and resulting ischemia, maintain colonization with "good" bacteria, and prevent bladder stones...
January 11, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29322284/identification-of-concepts-of-spiritual-care-in-iranian%C3%A2-peoples-with-multiple-sclerosis-a-qualitative-study
#16
Mohammad Reza Noormohammadi, Shahram Etemadifar, Leili Rabiei, Fatemeh Deris, Nahid Jivad, Reza Masoudi
Living with multiple sclerosis (MS) often needs attention combined with receiving the holistic care. Attention to spiritual care dimension is one of the most important aspects of care for these patients. This study aims at exploring and explaining dimensions of spiritual care for MS patients in care system of Iran. This study is conducted to explore the concept of spiritual care in care system of Iran during 2015-2016. Purposive sampling is done on 25 participants through unstructured interviews and observation of obtained data through conventional content analysis approach...
January 10, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29322234/-efficacy-of-a-ketogenic-diet-in-urological-cancers-patients-a-systematic-review
#17
P Maisch, J E Gschwend, M Retz
BACKGROUND: Beside the classical anticancer treatment tumor patients try to find proactive alternative therapies to fight their disease. Lifestyle changes such as introducing a ketogenic diet is one of the most popular among them. The German Association of Urological Oncology (AUO, Arbeitsgemeinschaft Urologische Onkologie) presents a systematic review investigating the evidence of ketogenic diet in cancer patients. MATERIALS AND METHODS: A systematic literature research was conducted in the databases Medline, Livivo, and the Cochrane Library...
January 10, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29321347/identification-of-housekeeping-genes-as-references-for-quantitative-real-time-rt-pcr-analysis-in-misgurnus-anguillicaudatus
#18
Xiaohua Xia, Weiran Huo, Ruyan Wan, Xiaopei Xia, Qiyan Du, Zhongjie Chang
Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) is a well-known method to quantify gene expression by comparing with the reference genes. Generally, housekeeping genes were set as references, as for their stable expression in varying conditions. Here, we try to evaluate few of such genes to identify suitable housekeeping genes as references for qRT-PCR analysis of gene expression in Misgurnus anguillicaudatus. This study evaluated the expression of four commonly used housekeeping genes, i...
December 2017: Journal of Genetics
https://www.readbyqxmd.com/read/29320497/survival-analysis-and-classification-methods-for-forest-fire-size
#19
Pier-Olivier Tremblay, Thierry Duchesne, Steven G Cumming
Factors affecting wildland-fire size distribution include weather, fuels, and fire suppression activities. We present a novel application of survival analysis to quantify the effects of these factors on a sample of sizes of lightning-caused fires from Alberta, Canada. Two events were observed for each fire: the size at initial assessment (by the first fire fighters to arrive at the scene) and the size at "being held" (a state when no further increase in size is expected). We developed a statistical classifier to try to predict cases where there will be a growth in fire size (i...
2018: PloS One
https://www.readbyqxmd.com/read/29320302/federal-right-to-try-legislation-threatening-the-fda-s-public-health-mission
#20
Steven Joffe, Holly Fernandez Lynch
The Food and Drug Administration (FDA) is the gatekeeper of the country’s drugs and medical devices. Originally created to prevent the misleading of patients, it was later tasked with ensuring the safety of medical products. In 1962, Congress expanded the FDA’s mandate again, requiring it to..
January 10, 2018: New England Journal of Medicine
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