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Trigeminal neuralgia etiology

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https://www.readbyqxmd.com/read/30134992/linac-stereotactic-radiosurgery-for-trigeminal-neuralgia-retrospective-two-institutional-examination-of-treatment-outcomes
#1
Ali Rashid, Bogdan Pintea, Thomas M Kinfe, Gunnar Surber, Klaus Hamm, Jan P Boström
BACKGROUND: In this pooled 2-center series LINAC radiosurgery (SRS) has been applied as a treatment option for a subset of refractory trigeminal neuralgia (TN) patients. This study approached to retrospectively assess the efficacy and safety of LINAC SRS and to provide a brief overview addressed to the technical development from frame-based towards frameless robotic SRS. METHODS: From 2001 to 2017 n = 55 patients (pts) were treated, n = 28 were female (51%), mean age: 66 years (range 36-93 years); TN etiology: 37 classic TN, 15 multiple sclerosis (MS)-related TN, 2 symptomatic TN, and 1 atypical TN...
August 22, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/30116913/the-neuralgias
#2
REVIEW
Danielle Wilhour, Stephanie J Nahas
PURPOSE OF REVIEW: Neuralgias are characterized by pain in the distribution of a cranial or cervical nerve. Typically, they are brief, paroxysmal, painful attacks, although continuous neuropathic pain may occur. The most commonly encountered conditions are trigeminal, postherpetic, and occipital neuralgia. Less common neuralgias include glossopharyngeal, superior laryngeal, auriculotemporal, and nervus intermedius neuralgia, among others. The approach to diagnosis and treatment of this group of disorders is reviewed...
August 16, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/30105142/unique-case-of-trigeminal-neuralgia-due-to-epstein-barr-virus-associated-b-cell-lymphomatoid-granulomatosis-of-the-meckel-s-cave-and-cavernous-sinus-important-clinical-and-therapeutic-implications
#3
Lucas Ezequiel Serrano Sponton, Ali Ayyad, Eleftherios Archavlis, Florian Alexander Ringel
Background: Trigeminal neuralgia (TN) represents one of the most disabling pain syndromes. Several diseases have been described as etiological triggers of TN, vascular compression of the trigeminal nerve being the most frequent cause. Here, we describe for the first time a rare case of TN caused by an infiltration of an isolated Epstein-Barr virus (EBV) B-cell lymphomatoid granulomatosis (LYG) mass into the Meckel's cave and cavernous sinus. Case Description: A 51-year-old woman undergoing immunosuppressant treatment for Crohn's disease presented due to right-sided TN...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30028264/hemi-laryngopharyngeal-spasm-as-a-novel-cause-of-inducible-laryngeal-obstruction-with-a-surgical-cure-report-of-3-cases
#4
Christopher R Honey, Murray D Morrison, Manraj K S Heran, Baljinder S Dhaliwal
Inducible laryngeal obstruction has been described under at least 40 different monikers, including vocal cord dysfunction, paroxysmal vocal fold motion, and irritable larynx. The etiology of this condition is believed to be laryngeal hyperactivity in response to psychological issues or acid reflux. Most patients are treated with some combination of proton pump inhibitors, speech therapy, and psychotherapy. However, a small cohort of patients remains refractory to all medical interventions. The authors describe a novel condition, hemi-laryngopharyngeal spasm (HELPS), which can cause severe episodic stridor leading to unconsciousness in association with cough...
July 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29996129/mandibular-myalgia-and-miniscule-meckel-s-caves
#5
Srihari Sundararajan, Laurie A Loevner, Suyash Mohan
Trigeminal neuropathy manifests as episodic sharp, shooting pain in the maxillofacial region. Contributory etiologies are myriad, ranging from central pathology affecting its origin in the brainstem to peripheral processes affecting their distal-most insertion sites. We present a case of bilateral hypoplastic Meckel's caves in an adult patient leading to the clinical symptomology of trigeminal neuralgia. To the best of our knowledge, this is the only report of its kind highlighting this anatomic variant.
2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29676696/tentorial-sling-for-microvascular-decompression-in-patients-with-trigeminal-neuralgia-a-description-of-operative-technique-and-clinical-outcomes
#6
Jeffrey A Steinberg, Jayson Sack, Bayard Wilson, David Weingarten, Bob Carter, Alexander Khalessi, Sharona Ben-Haim, John Alksne
OBJECTIVE Trigeminal neuralgia is a debilitating pain disorder most often caused by arterial compression of the trigeminal nerve, although there are other etiologies. Microvascular decompression (MVD) remains the most definitive treatment for this disorder, with cure rates reported between 60% and 80%. Traditional MVD techniques involve a retrosigmoid craniotomy with placement of an inert foreign material, such as Teflon, between the nerve and compressive vessel. Recurrence of trigeminal neuralgia after MVD has been associated with vessel migration, adhesion formation, and arterial pulsation against the Teflon abutting the nerve...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29486311/microvascular-decompression-and-arachnoid-cyst-fenestration-for-treatment-of-medulla-oblongata-compression-caused-by-arachnoid-cyst-vascular-loop-complex
#7
Jehad Zakaria, Michael Wemhoff, Douglas Anderson
BACKGROUND: Vascular compression of neural structures has long been established as an etiology for dysfunction of multiple cranial nerves. Classically, as is the case of trigeminal neuralgia, vascular compression by an offending artery and sometimes vein-exerting pressure at the root entry zone of the trigeminal nerve can lead to the characteristic pain syndrome. CASE DESCRIPTION: In these cases, microvascular decompression is an effective, durable surgical intervention to relieve the neuralgia...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29477005/computed-tomography-cisternography-for-evaluation-of-trigeminal-neuralgia-when-magnetic-resonance-imaging-is-contraindicated-case-report-and-review-of-the-literature
#8
REVIEW
Vadim Gospodarev, Vikram Chakravarthy, Casey Harms, Hannah Myers, Brett Kaplan, Esther Kim, Matthew Pond, Kenneth De Los Reyes
BACKGROUND: Trigeminal neuralgia (TGN) causes severe unilateral facial pain. The etiology is hypothesized to be segmental demyelination of the trigeminal nerve root via compression by the superior cerebellar artery (SCA). Microvascular decompression (MVD) allows immediate and long-term pain relief. Preoperative evaluation includes magnetic resonance imaging (MRI) and/or magnetic resonance angiography of the brain. Having a pacemaker is a contraindication for MRI. There have been isolated reports of using computed tomography (CT) cisternography scans for radiation planning for TGN...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29203312/microvascular-decompression-for-treatment-of-trigeminal-neuralgia-factors-that-predict-complete-pain-relief-and-study-of-efficacy-and-safety-in-older-patients
#9
Sarun Nunta-Aree, Kasemsak Patiwech, Bunpot Sitthinamsuwan
OBJECTIVE: Microvascular decompression (MVD) is an effective method for directly treating the etiology of trigeminal neuralgia (TGN). This study aims to investigate the factors that predict complete pain relief after MVD for treatment of TGN, and to study efficacy and safety in older patients. METHODS: This study was conducted in patients with TGN that were treated by MVD at Siriraj Hospital between 2004 and 2015. Cases with secondary TGN were excluded. Data was gathered from medical records, preoperative magnetic resonance imaging, intraoperative findings, and by telephone in patients lost to follow-up...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29200179/structural-and-functional-abnormalities-of-the-insular-cortex-in-trigeminal-neuralgia-a-multimodal-magnetic-resonance-imaging-analysis
#10
Yue Wang, Yuanchao Zhang, Jinlei Zhang, Jiaojian Wang, Jinping Xu, Jie Li, Gaoyu Cui, Jiuquan Zhang
Trigeminal neuralgia (TN) is a chronic neuropathic pain disorder characterized by intense, lancinating attacks of facial pain. Increasing evidence suggests that TN is accompanied by abnormalities in brain morphology, white matter microstructure, and function. However, whether these abnormalities are linked or reflect independent etiologies remains unknown. Using multimodal magnetic resonance imaging data of 20 patients with TN and 21 healthy controls, we investigated cortical gyrification abnormalities, their relationships with abnormalities of the underlying white matter microstructure and gray matter morphology, as well as their functional significance in TN...
March 2018: Pain
https://www.readbyqxmd.com/read/29142153/prognostic-impact-and-post-operative-evaluation-of-volumetric-measurement-of-the-cerebellopontine-cistern-in-trigeminal-neuralgia-using-3-tesla-magnetic-resonance-imaging
#11
Yoshiki Obata, Yoshihisa Kawano, Yoji Tanaka, Taketoshi Maehara
The aim of this study was to evaluate the importance of pre- and post-operative volumetric measurement of the cerebellopontine angle (CPA) using 3 Tesla (3T) magnetic resonance imaging (MRI). Between April 2012 and December 2015, a total of 87 consecutive patients underwent microvascular decompression (MVD) for trigeminal neuralgia (TN), of whom 51 with primary TN caused by arterial compression were enrolled in this study. Bilateral CPA cistern volume was evaluated using 3T MRI before and after surgery; the Cistern Deviation Index was used to represent the degree of deviation of the CPA cistern...
February 15, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29120554/accommodation-to-diagnosis-of-trigeminal-neuralgia
#12
REVIEW
Vanja Bašić Kes, Lucija Zadro Matovina
Trigeminal neuralgia is one of the most common causes of facial pain. It implies short lasting episodes of unilateral electric shock-like pain with abrupt onset and termination, in the distribution of one or more divisions of the trigeminal nerve that are triggered by innocuous stimuli. Most cases of trigeminal neuralgia are caused by compression of the trigeminal nerve root. Depending on the etiology, trigeminal neuralgia can be classified as classic trigeminal neuralgia or painful trigeminal neuropathy. It may be precipitated by some actions at trigger zones...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29066235/pregabalin-as-a-salvage-preoperative-treatment-for-refractory-trigeminal-neuralgia
#13
Tadashi Hamasaki, Shigetoshi Yano, Kazumi Nakamura, Kazumichi Yamada
Only few studies have investigated the effectiveness of pregabalin (PGB) treatment for trigeminal neuralgia (TN). We aimed to retrospectively analyze the effectiveness of PGB treatment in refractory TN as a salvage treatment preceding surgery. Of 61 patients with TN refractory to prior treatment with carbamazepine (CBZ), we enrolled 33 patients in our study who agreed to receive PGB before they underwent surgery. The patients were divided into effective and ineffective groups depending on the patient-reported outcome...
January 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29039156/-vertebrobasilar-artery-dolichoectesia-and-pain-coincidence-or-etiology
#14
Murat Alemdar
Dolichoectesia is described as elongation, widening, and tortuosity of an artery. Most commonly involved vessels are the intracranial vertebral and basilar arteries. Vertebrobasilar artery dolichoectesia is usually asymptomatic. Cerebral ischemia, hemorrhage, or compression findings due to mass effect can be seen in symptomatic patients. Although there are case reports of trigeminal neuralgia due to fifth cranial nerve compression in the literature, to the best of our knowledge, neither hemicranial nor continuous facial pain secondary to vertebrobasilar artery dolichoectesia has been reported previously...
July 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29033487/gingival-hyperplasia-should-drug-interaction-be-blamed-for
#15
Pramod Kumar Sharma, Arup Kumar Misra, Ankita Chugh, Vinay Kumar Chugh, Nitesh Gonnade, Surjit Singh
Gingival overgrowth (GO) is one of the common findings in clinical practice. There could be several causes including drugs associated with the GO. Carbamazepine (CBZ) and amlodipine are the drugs which are infrequently documented as a cause in inducing the gingival hyperplasia. Certain drugs in the body fluid might limit the population of plaque bacteria and alter their metabolism that in turn induce the inflammatory mediators and also activate the genetic and biochemical factors responsible for gingival fibroblast growth...
May 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29026761/postherpetic-neuralgia-diabetic-neuropathy-and-trigeminal-neuralgia-chronic-peripheral-neuropathic-pain-in-58-480-rural-italian-primary-care-patients
#16
Nicola Buono, Hans Thulesius, Ferdinando Petrazzuoli, Elena Castelli, Marco Cambielli
INTRODUCTION: Chronic peripheral neuropathic pain (CPNP) is a condition due to peripheral nervous system diseases or injury, but its prevalence is unknown in Italian primary care. AIM: The aim of this study is to assess the prevalence of CPNP in a rural primary care area in Northern Italy. MATERIALS AND METHODS: A multicenter audit study was carried out in a rural area in Northern Italy with 113 participating general practitioners (GPs) seeing 58,480 patients >18 years during 3 months...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28947688/-pathophysiology-and-treatment-of-orofacial-pain
#17
Masamichi Shinoda, Noboru Noma
"Pain" is one of body defense mechanisms and crucial for the life support. However, orofacial pain such as myofascial pain syndrome, burning mouth syndrome and trigeminal neuralgia plays no part in body defense mechanisms and requires therapeutic intervention. Recent studies have indicated that plastic changes in the activities of trigeminal neurons, satellite glial cells in trigeminal ganglion, secondary neurons, microglia and astrocytes in trigeminal spinal subnucleus following orofacial inflammation and trigeminal nerve injury are responsible for orofacial pain mechanisms...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28900824/external-nasal-neuralgia-an-update
#18
REVIEW
Hida Nierenburg, Morgane Swift Morris
PURPOSE OF REVIEW: External nasal neuralgia is a rare syndrome of atypical facial pain for which there is limited reports in the scientific literature. We aim to review diagnosis and provide an update on treatments for this rare condition. RECENT FINDINGS: Etiology has been documented as post-traumatic due to direct trauma to the nose area and in few case reports, idiopathic. Sensory innervation of the nose arises from the ophthalmic and maxillary divisions of the trigeminal nerve...
September 13, 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28804114/clinical-epidemiological-and-etiological-studies-of-adult-aseptic-meningitis-report-of-11-cases-with-varicella-zoster-virus-meningitis
#19
Shinichi Takeshima, Yuji Shiga, Takahiro Himeno, Keisuke Tachiyama, Teppei Kamimura, Ryuhei Kono, Makoto Takemaru, Jun Takeshita, Yutaka Shimoe, Masaru Kuriyama
We treated 11 cases (52.7 ± 14.9 years, all male) with varicella zoster virus (VZV) meningitis and 437 cases with adult aseptic meningitis from 2004 to 2016. The incidence rate of adult VZV meningitis in the cases with aseptic meningitis was 2.5%. Herpes zoster infections are reported to have occurred frequently in summer and autumn. VZV meningitis also occurred frequently in the similar seasons, in our patients. The diagnoses were confirmed in 9 cases with positive VZV-DNA in the cerebrospinal fluid and in 2 cases with high VZV-IgG indexes (> 2...
September 30, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28512048/combined-hyperactive-dysfunction-syndrome-of-the-cranial-nerves-a-retrospective-systematic-study-of-clinical-characteristics-in-44-patients
#20
Jingwei Cao, Jie Jiao, Zhenhui Du, Wenzhe Xu, Bin Sun, Feng Li, Yuguang Liu
BACKGROUND: Combined hyperactive dysfunction syndrome (HDS) is defined as the combination symptoms arising from overactivity in cranial nerves, specifically, trigeminal neuralgia (TN), hemifacial spasm (HFS), and glossopharyngeal neuralgia (GPN), without an obvious explanatory structural lesion. This study retrospectively analyzes the clinical characteristics of combined HDS treated with microvascular decompression (MVD) in a single institution. METHODS: A total of 1450 patients with HDS were treated with MVD in our department during a 10-year period, among which 44 cases of combined HDS were identified...
August 2017: World Neurosurgery
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