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DIC and PE

Hanan M El-Gowelli, Karim S Ibrahim, Ahmed F El-Yazbi, Mahmoud M El-Mas
AIMS: The hypertensive effect of the immunosuppressant drug cyclosporine (CSA) is paralleled, and probably triggered, by impaired arterial baroreceptor sensitivity (BRS). Here we asked if these effects of CSA are influenced by co-administration of nonsteroidal antiinflammatory drugs (NSAIDs) and if the oxidative NADPH-oxidase (NADPHox)/Rho-kinase (ROCK) pathway mediates this interaction. MATERIALS AND METHODS: Female rats were treated for 10days with CSA (25mg/kg/day), diclofenac (DIC, COX-1/COX-2 inhibitor, 1mg/kg/day), celecoxib (COX-2 inhibitor, 10mg/kg/day), or their combinations...
July 21, 2017: Life Sciences
Tetsuya Sakai, Daisuke Taniyama, Saeko Takahashi, Morio Nakamura, Takashi Takahashi
Group A Streptococcus (GAS, Streptococcus pyogenes) causes invasive infections including streptococcal toxic shock syndrome (STSS) and local infections. To our knowledge, this is the first report of a case of an invasive GAS infection with pneumonia and pleural empyema (PE) followed by STSS (disseminated intravascular coagulation [DIC] and acute renal insufficiency) in a healthy male adult. He received combined supportive therapies of PE drainage, anti-DIC agent, hemodialysis, and antimicrobials and eventually made a clinical recovery...
2017: IDCases
Anupama Dave, Laxmi Maru, Astha Jain
OBJECTIVE: The aim of the study was to find out the role of Serum lactate dehydrogenase in prediction of adverse outcomes of PE & E i.e., severity of disease and occurrence of complications. MATERIALS AND METHODS: This study was conducted in the Department of Obstetrics and Gynaecology, MGM Medical College, Indore. A total of 200 women were studied; they were divided into control (n = 100), severe pre-eclampsia (n = 32), eclampsia (n = 68). Demographic and hematological parameters were studied including LDH levels...
February 2016: Journal of Obstetrics and Gynaecology of India
S Rana, M Hacker, A Merport, S Salahuddin, S Verlohren, F Perschel, S A Karumanchi
INTRODUCTION: Preeclampsia (PE) is a pregnancy specific hypertensive disorder with an overall incidence of 5-8% among all pregnancies.Incidence of PE in twins is about 2-4 fold higher compared to singletons.Angiogenic factors are implicated in pathogenesis of PE and related adverse outcomes.No studies exist evaluating angiogenic factor assessment in twin pregnancies complicated by PE or use of these proteins for prediction of PE-related adverse outcomes in twins. OBJECTIVES: Our objective was to evaluate whether angiogenic factor levels correlate with the diagnosis of PE and predict adverse maternal and perinatal outcomes in women with twin pregnancy...
July 2012: Pregnancy Hypertension
Morteza Naserbakht, Alireza Noroozi, Ahmad Hajebi
OBJECTIVES: Our objective was to design an RCT in order to assess the effects of adding a brief skill-based psychoeducation (PE) to routine Needle and Syringe Programs to reduce injection and high risk sexual behaviors associated with Human Immunodeficiency Virus (HIV) infection among referrals of Drop-in Centers (DICs). METHOD/DESIGN: This was a randomized control trial with the primary hypothesis that adding skill-based PE to the routine needle syringe program (NSP) provided in the DICs would be more effective in reducing injection and high risk sexual behaviors associated with HIV infection compared to the routine programs...
July 2014: Iranian Journal of Psychiatry
Li-Li Zhou, Yue Han, Qian Zhu, Lu-Ping Hu, Shi-Xiang Zhao, Ming-Qing Zhu, Lan Dai, Wen-Hong Shen, Li Chen, De-Pei Wu
Objective of this study was to detect the level of tissue factor-positive microparticles (TF(+)MP) by flow cytometry (FCM) and to analyze its clinical significance in the haemostatic disorder. TF(+) MP was detected by FCM using antibody CD142-PE in 25 cases of acute promyelocytic leukemia (APL), 20 cases of hemostatic diseases and 20 healthy adults as controls. The differences of TF(+) MP between various groups were determined. The results showed that the level of TF(+) MP in the patients with thrombotic complications was significantly higher than that in the healthy adults (P < 0...
August 2012: Zhongguo Shi Yan Xue Ye Xue za Zhi
A-S Ducloy-Bouthors
Clotting disorders are associated with the severe, early and complicated forms of PE. Compensated hypercoagulability states associated with a thrombocytopenia (PLT<150k/mm(3)) affect 25 to 50% of severe PE patients. Laboratory markers of platelet and endothelial activation are the early increase of fibronectin levels, the worsening of the thrombocytopenia and the raised platelet turnover. The excessive thrombin formation is physiologically compensated by a rise in thrombin-antithrombin (TAT) complex levels, which is the most specific marker of a PE pregnancy, and a decrease in anti-thrombin (AT) activity...
May 2010: Annales Françaises D'anesthèsie et de Rèanimation
J M Leitner, B Jilma, A O Spiel, F Sterz, A N Laggner, K M Janata
SUMMARY BACKGROUND: A consumptive coagulopathy resembling disseminated intravascular coagulation (DIC) has been seen in patients with massive pulmonary embolism (PE). We hypothesized that a DIC-like condition is relevant in patients whose pulmonary embolism leads to cardiopulmonary arrest and cardiopulmonary resuscitation (CPR). METHODS: This hypothesis was tested by the use of a database consisting of all cases of PE diagnosed at the Department of Emergency Medicine from June 1993 to October 2007...
July 2010: Journal of Thrombosis and Haemostasis: JTH
R Rahim, K Nahar, I A Khan
Hypertensive disorders are most common medical complication of pregnancy and the major causes of maternal & perinatal disease and death worldwide. The aim of the study was to see the platelet count in pregnancy induced hypertension (PIH). It was a prospective study. The study was done on 100 cases of PIH patients in Gynae & Obstetrics department of Mymensingh Medical College Hospital (MMCH) during the period of January to July 2006. Among the 100 cases 60 were eclamptic, 34 were pre eclamptic (PE) and 06 were gestational hypertensive (GH) patients...
January 2010: Mymensingh Medical Journal: MMJ
Hideki Nomura, Hideo Wada, Toshiro Mizuno, Yoshiki Yamashita, Kanako Saito, Shigehisa Kitano, Naoyuki Katayama, Norikazu Yamada, Takashi Sugiyama, Akihiro Sudo, Masanobu Usui, Shuji Isaji, Tsutomu Nobori
BACKGROUND: Most patients with malignant diseases are frequently complicated with some type of thrombosis, such as disseminated intravascular coagulation (DIC) or deep vein thrombosis (DVT)/pulmonary embolism (PE). OBJECTIVE: The cohort and retrospective study was designed to examine the frequency of thrombosis in patients with malignant diseases and to evaluate the efficacy of D-dimer and soluble fibrin (SF) for the diagnosis of thrombosis. PATIENTS/METHODS: The plasma concentrations of D-dimer and SF were measured in patients with malignant diseases suspected of having thrombosis...
June 2010: Clinical and Applied Thrombosis/hemostasis
Sami J Taipale, Eloni Sonninen
The precise delta(13)C value of dissolved inorganic carbon (DIC) is important for various types of ecological studies. Without a preservation agent, microbial degradation of organic compounds continues in water samples and the delta(13)C value of DIC will become more depleted with time. HgCl(2) or acidification is often used to prevent microbial activity in water samples collected for carbon isotope ratio analyses of DIC. Mercury compounds are toxic and result in waste disposal problems. Other inhibiting agents or preservation methods are therefore needed...
August 30, 2009: Rapid Communications in Mass Spectrometry: RCM
Hideki Nomura, Hideo Wada, Toshiro Mizuno, Naoyuki Katayama, Yasunori Abe, Maki Noda, Kaname Nakatani, Takeshi Matsumoto, Satoshi Ota, Norikazu Yamada, Akihiro Sudo, Atsumasa Uchida, Tsutomu Nobori
The D-dimer levels are considered to be useful for the diagnosis of thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing thrombosis based on the D-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of D-dimer levels as a negative predictor for thrombosis. The plasma concentrations of D-dimer were measured in inpatients suspected of having thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of thrombosis...
April 2008: International Journal of Hematology
Yi-Ming Yang, Ting Liu
A 30 years-old man was administrated with dizziness and fatigue for half month, and the big toe on his left foot got the prolonged bleeding of wound complicated with fever 7 days before the admission. The physical examination (PE) discovered that the case suffered from the anemic appearance, lower part tenderness of sternum, petechiae and purpura on skin of lower extremities, and with remaining not to be remarkable. The examination of blood routine showed WBC 2.3 x 10(9)/L, Hb 60/L, BPC 34 x 10(9)/L and blasts 0...
November 2006: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Koichi Kozaki, Hiroto Egawa, Mikiko Ueda, Fumitaka Oike, Atsushi Yoshizawa, Atsushi Fukatsu, Yasutsugu Takada
Liver transplantation is a radical surgical therapy for end-stage liver disease. Although in Japan organ transplantation from brain-dead donors (BDD) has been allowed since October 1997, to date, only 29 liver grafts from BDD have been obtained. Thus, most of the liver transplantations carried out use living-donor liver transplantation (LDLT), and BDD liver transplantation is only used in rare cases. In order to carry out LDLT more safely, apheresis (plasmapheresis: PE) plays a major role in our country because of the prevalence of LDLT wherein later re-transplantation is difficult...
October 2006: Therapeutic Apheresis and Dialysis
Angus P R Johnston, Alexander N Zelikin, Lillian Lee, Frank Caruso
Colloidal particles prepared by using the layer-by-layer technique are increasingly finding application in diagnostics, drug delivery, and sensing. Herein, we outline methods for applying three established techniques, confocal laser scanning microscopy (CLSM), flow cytometry, and differential interference contrast (DIC) microscopy, to characterize ultrathin films of poly(styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) assembled on silica particles. Both CLSM and flow cytometry require the use of fluorescently labeled polyelectrolytes (PEs)...
August 15, 2006: Analytical Chemistry
Yoshinori Horie, Hiromasa Ishii, Toshifumi Hibi
BACKGROUND: Recently, the incidence of alcoholic liver disease (ALD) has been increasing in Japan; this associated with an increase in alcoholic beverage consumption. Multiple organ failures are frequently observed in patients with severe alcoholic hepatitis (AH), most of whom have a poor prognosis similar to fulminant hepatitis; as well numbers of severe AH patients appear to be increasing. Although prognosis of fulminant hepatitis in Japan has been recently improved by intensive treatments such as plasma exchange (PE) that of severe AH has not changed...
December 2005: Alcoholism, Clinical and Experimental Research
Yuko Kamikura, Hideo Wada, Tsutomu Nobori, Toshihiko Kobayashi, Tomohiro Sase, Masakatsu Nishikawa, Ken Ishikura, Norikazu Yamada, Yasunori Abe, Junji Nishioka, Takeshi Nakano, Hiroshi Shiku
Tissue factor (TF) mRNA levels in leukocyte and TF antigen in plasma were examined in patients with deep vein thrombosis (DVT). Although TF mRNA levels in leukocytes were higher in patients with DVT than in healthy volunteers, they were lower in patients with DVT than in those with solid cancer and those with disseminated intravascular coagulation (DIC). On the other hand, the plasma levels of TF antigens were markedly high in patients with DVT/pulmonary embolism (PE). Analysis of the role of underlying disease of DVT showed no significant difference in TF mRNA levels and TF antigens among patients with solid cancer, post-surgical, other diseases and those free of underlying diseases...
2005: Thrombosis Research
Jörg H Kleinschmidt, Lukas K Tamm
The self-assembled supramolecular structures of diacylphosphatidylcholine (diC(n)PC), diacylphosphatidylethanolamine (diC(n)PE), diacylphosphatidyglycerol (diC(n)PG), and diacylphosphatidylserine (diC(n)PS) were investigated by (31)P nuclear magnetic resonance (NMR) spectroscopy as a function of the hydrophobic acyl chain length. Short-chain homologs of these lipids formed micelles, and longer-chain homologs formed bilayers. The shortest acyl chain lengths that supported bilayer structures depended on the headgroup of the lipids...
August 2002: Biophysical Journal
M T DeSancho, J H Rand
Alterations in hemostasis are common in patients with cancer admitted to the ICU. Depending on the underlying disease and specific hemostatic abnormality, the patient with cancer may develop bleeding, thrombosis, or both, such as DIC. Bleeding complications usually result from abnormalities in platelets or deficiency of coagulation factors and require specific blood or coagulation factor replacement. Similarly, critically ill patients with cancer are predisposed to thrombotic complications such as DVT, PE, and central vein thrombosis, the last as a result of the widespread use of long-term indwelling catheter devices...
July 2001: Critical Care Clinics
B Tenchov, R Koynova, G Rapp
Formation of low-temperature ordered gel phases in several fully hydrated phosphatidylethanolamines (PEs) and phosphatidylcholines (PCs) with saturated chains as well as in dipalmitoylphosphatidylglycerol (DPPG) was observed by synchrotron x-ray diffraction, microcalorimetry, and densitometry. The diffraction patterns recorded during slow cooling show that the gel-phase chain reflection cooperatively splits into two reflections, signaling a transformation of the usual gel phase into a more ordered phase, with an orthorhombic chain packing (the Y-transition)...
April 2001: Biophysical Journal
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