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diagnostic criteria for atopic dermatitis

Derek Y Hsu, Prarthana Dalal, Kimberly A Sable, Nihal Voruganti, Beatrice Nardone, Dennis West, Jonathan I Silverberg
BACKGROUND: Evaluation of large-scale data sets is needed to better understand the epidemiology, cost and burden of atopic dermatitis (AD). We sought to validate the use of ICD-9-CM codes for identifying AD. METHODS: Patients from a large metropolitan quaternary care medical center with a diagnostic code of either 691.8 (AD) or 692.9 (eczema and contact dermatitis) were queried. Medical records were reviewed for demographics, Hanifin & Rajka (H&R) and United Kingdom Working Party (UKWP) criteria...
December 20, 2016: Allergy
Li Wang, Lin-Feng Li
BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease with an increasingly significant prevalence. The prevalence of AD depends greatly on how its diagnosis is done. The UK Working Party's diagnostic criteria for AD are simple and easy to apply without invasive laboratory tests. This study assessed the clinical utility of these criteria in China. METHODS: Data were collected from 6208 patients at 31 tertiary hospitals in 13 Chinese provinces/municipalities from March 2014 to May 2014...
2016: Chinese Medical Journal
Pınar Uysal, Sibelnur Avcil, Burçin İrem Abas, Çiğdem Yenisey
BACKGROUND: Increased reactive oxygen species (ROS) and oxidative stress (OS) has been reported in many allergic and inflammatory skin diseases, including urticaria, psoriasis, and atopic dermatitis (AD). Melatonin is a hormone secreted from the pineal gland and is a potent antioxidant. OBJECTIVE: The aim of the study was to measure serum antioxidant melatonin, oxidants of nitric oxide (NO), and malondialdehyde levels to calculate the serum oxidant-antioxidant balance based on the NO/melatonin and malondialdehyde/melatonin ratios and to determine the correlation with the disease severity in children with AD...
October 2016: American Journal of Clinical Dermatology
Antonio Chuh, Vijay Zawar, Albert Lee, Gabriel Sciallis
OBJECTIVES: To investigate whether Gianotti-Crosti syndrome (GCS) in children is associated with atopy. METHODS: The setting was two outpatient clinic. Diagnoses of asthma and atopic dermatitis (AD) were made according to internationally accepted diagnostic criteria. Allergic rhinitis, atopic urticaria, and allergic conjunctivitis were diagnosed clinically. Participants were children with GCS diagnosed over the previous 5 years. For any child with GCS, we extracted the record of the subsequent age and sex pair-matched child seen for problems unrelated to the skin as controls...
September 2016: Pediatric Dermatology
Yun-Hsia Hsiao, Charles Chen, Ton Willemse
This study was conducted to evaluate the effects of cetirizine in dogs with atopic dermatitis (AD) while fulfilling Favrot's diagnostic clinical criteria. Dogs received either 3 mg/kg cetirizine (n = 27), or a placebo (n = 23) orally once daily for 14 days in a randomized, double blind, placebo-controlled study, without concomitant medication. The effects were evaluated using a pruritus visual analog scale at the start (day 0) and at day 14. After 14 days, cetirizine clearly had no effect on the pruritus in dogs with chronic AD, and there was no significant difference between groups...
December 30, 2016: Journal of Veterinary Science
Maria Magdalena Roth, Patricia Cristodor, George Kroumpouzos
Prurigo (PP) and pruritic folliculitis of pregnancy (PFP) are poorly characterized entities. Traditionally classified under specific dermatoses of pregnancy, they were reclassified under a new umbrella entity, atopic eruption of pregnancy (AEP), which also includes atopic dermatitis (AD) that can worsen or present for the first time in pregnancy. Still, several aspects of AEP have not been adequately elucidated. It needs to be clarified whether it is the intrinsic ("nonallergic" or "atopiform dermatitis") or extrinsic (immunoglobulin E-associated) AD that is affected by pregnancy...
May 2016: Clinics in Dermatology
Jonathan I Silverberg, Diane B Nelson, Gil Yosipovitch
Atopic dermatitis (AD), a chronic inflammatory skin disease affecting children and adults, presents as mild-to-moderate disease in the majority of patients. Pruritus, one of the key diagnostic criteria for AD, is associated with reduced quality of life and disease aggravation. Current treatments include emollients and topical pharmaceutical agents. Topical corticosteroids (TCSs) are commonly used, but are associated with safety concerns with cutaneous and systemic side effects. Topical calcineurin inhibitors (TCIs) inhibit T-lymphocyte activation, but their use is limited because of application-site infections and a boxed warning for potential malignancy risk...
November 2016: Journal of Dermatological Treatment
Ping Liu, Yan Zhao, Zhang-Lei Mu, Qian-Jin Lu, Li Zhang, Xu Yao, Min Zheng, Yi-Wen Tang, Xin-Xiang Lu, Xiu-Juan Xia, You-Kun Lin, Yu-Zhen Li, Cai-Xia Tu, Zhi-Rong Yao, Jin-Hua Xu, Wei Li, Wei Lai, Hui-Min Yang, Hong-Fu Xie, Xiu-Ping Han, Zhi-Qiang Xie, Xiang Nong, Zai-Pei Guo, Dan-Qi Deng, Tong-Xin Shi, Jian-Zhong Zhang
BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczema/AD and to propose Chinese diagnostic criteria for adult/adolescent AD...
April 5, 2016: Chinese Medical Journal
Agata Filipowska-Grońska, Maria Weryńska-Kalemba, Andrzej Bożek, Barbara Filipowska, Jadwiga Żebracka-Gala, Dagmara Rusinek, Dorota Kula, Jerzy Jarząb
INTRODUCTION: As far as pathogenesis of the atopic dermatitis (AD) is concerned, the roles of an impaired epidermal barrier and cornified cell envelope are widely emphasized. AIM: The assessment of mutations of the filaggrin gene and their connection with the clinical picture of AD as well as selected allergological and environmental indicators. MATERIAL AND METHODS: 105 patients with diagnosed AD on the basis of diagnostic criteria were included...
February 2016: Postȩpy Dermatologii i Alergologii
Fariba Jaffary, Gita Faghihi, Arghavan Mokhtarian, Sayed Mohsen Hosseini
BACKGROUND: The pathogenesis of atopic dermatitis (AD) remains to be determined; recently a possible change in the immune system with production of immunoglobulins is proposed. As vitamin E is a potent antioxidant, with the ability to decrease the serum levels of immunoglobulin E (IgE) in atopic patients, we aimed to evaluate the effect of oral vitamin E on treatment of AD. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial comprised seventy participants with mild-to-moderate AD, based on the Hanifin and Rajka diagnostic criteria...
November 2015: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Seung Chul Lee, Jung Min Bae, Ho June Lee, Hyun Jung Kim, Byung Soo Kim, Kapsok Li, Jae We Cho, Chang Ook Park, Sang Hyun Cho, Kwang Hoon Lee, Do Won Kim, Chun Wook Park, Kyu Han Kim
PURPOSE: Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been proposed to detect the major group of AD with flexural dermatitis. We aimed to develop novel, questionnaire-based diagnostic criteria for childhood AD, which can detect more comprehensive AD including non-flexural type. METHODS: The draft version of questionnaire to detect childhood AD was prepared to be used for preliminary hospital- (n=1,756) and community-based (n=1,320) surveys...
May 2016: Allergy, Asthma & Immunology Research
Renata Robl, Marjorie Uber, Kerstin Taniguchi Abagge, Monica Nunes Lima, Vânia Oliveira Carvalho
BACKGOUND/OBJECTIVES: The objective of the current study was to determine the relationship between serum vitamin D levels and the severity of atopic dermatitis (AD) in a Brazilian population. METHODS: This was a cross-sectional study of patients younger than 14 years of age seen from April to November 2013. All patients fulfilled the Hanifin and Rajka Diagnostic Criteria for AD diagnosis. Disease severity was determined using the SCORing Atopic Dermatitis index and classified as mild (<25), moderate (25-50), or severe (>50)...
May 2016: Pediatric Dermatology
Seung-Chul Lee
Atopic dermatitis (AD) is a heterogeneous disease that manifests with a wide variety of clinical symptoms and signs. Due to the lack of definitive biomarkers for AD, it is very difficult to set up standard diagnostic criteria for AD which cover the entire spectrum of AD patients. Various instruments have been proposed for AD diagnosis, and they can be classified into a hospital setting or a community setting. From the preventive medicine viewpoint, questionnaire-based diagnostic criteria in a community setting are important to detect and manage childhood AD patients properly...
April 2016: Journal of Dermatology
Lei Bao, Huayi Zhang, Girish C Mohan, Kui Shen, Lawrence S Chan
IL-4 plays an important role in the pathogenesis of atopic dermatitis (AD), a common chronic inflammatory skin disease. We have generated IL-4 transgenic (Tg) mice by over-expressing IL-4 in the epidermis. These mice spontaneously develop chronic pruritic inflammatory skin lesions, which meet the clinical and histological diagnostic criteria for human AD. Systemic survey of immune-related genes in this mouse model, however, has not been performed. In this study, we utilize PCR array technique to examine hundreds of inflammation-related genes in the IL-4 Tg mice before and after the onset of skin lesions as well as in their wild type (WT) littermates...
February 2016: Molecular and Cellular Probes
E Ellenbogen, U Wesselmann, S C Hofmann, P Lehmann
BACKGROUND: Photosensitive atopic dermatitis (PhAD) is a scarcely reported entity characterized clinically by a photodistributed rash in patients who fulfil the criteria for atopic dermatitis (AD). OBJECTIVES: The aim of this retrospective study is to define significant clinical, laboratory and immunological parameters as well as photobiological features for diagnosing PhAD. METHODS: We conducted a single-centre retrospective analysis of 17 patients with long-standing AD who in the disease course suddenly developed photosensitivity...
February 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Patrick Hensel, Domenico Santoro, Claude Favrot, Peter Hill, Craig Griffin
BACKGROUND: Canine atopic dermatitis (AD) is a common, genetically predisposed, inflammatory and pruritic skin disease. The variation in clinical presentations, due to genetic factors, extent of the lesions, stage of the disease, secondary infections, as well as resemblance to other non-atopic related skin diseases, can complicate a diagnosis of canine AD. A sub-group of the International Committee for Allergic Diseases in Animals (ICADA) was tasked with the development of a set of practical guidelines that can be used to assist practitioners and researchers in the diagnosis of canine AD...
2015: BMC Veterinary Research
Sinéad M O'Donovan, Jonathan O'B Hourihane, Deirdre M Murray, Louise C Kenny, Ali S Khashan, Carol Ní Chaoimh, Alan D Irvine, Mairead Kiely
BACKGROUND: Early nutrition and adiposity have been linked to atopic dermatitis (AD) development. OBJECTIVE: We sought to describe risk factors for AD in the first year of life in infants participating in the Cork BASELINE birth cohort study (n = 1537). METHODS: Prospective data on early-life events, infant feeding, and nutritional and environmental exposures were collected at 15 weeks' gestation, birth, and 2, 6, and 12 months of age. Body composition was assessed by using air displacement plethysmography at day 2 and 2 months...
January 2016: Journal of Allergy and Clinical Immunology
E Kandelaki, N Kavlashvili, M Kherkheulidze, I Chkhaidze
A link between atopic dermatitis (AD,eczema) and emotional and behavioral dysfunction is more or less well recognized but concern still exists. Children with a chronic health condition have long been considered at excess risk for psychosocial morbidity. But psychosocial morbidity is less linked and studied in connection with other disease, especially AD. As mentioned before, AD is the most prevalent chronic disease in young children. The aim of the study was assessment of incidence of atopic dermatitis in children of 5-6 years with developmental and behavioral problems...
June 2015: Georgian Medical News
Nina G Heede, Jacob P Thyssen, Betina H Thuesen, Allan Linneberg, Jeanne D Johansen
BACKGROUND: Common filaggrin (FLG) null mutations are associated with severe and early onset of atopic dermatitis (AD). To date, few studies have investigated anatomical patterns of dermatitis and none has been conducted in the general population. OBJECTIVE: We evaluated patterns of dermatitis in an adult general population stratified by FLG genotype. METHODS: Data from a population-based cohort study with a 5-year follow-up were used. This study included 2143 participants aged 18 to 72 years...
March 2015: Journal of the American Academy of Dermatology
Giulio Perugi, Giuseppe Quaranta, Serena Belletti, Francesca Casalini, Nicola Mosti, Cristina Toni, Liliana Dell'Osso
BACKGROUND: Patients with bipolar disorder (BD) suffer from greater physical morbidity and mortality than the general population. The aim of the present study is to explore the prevalence and clinical correlates of General Medical Conditions (GMC) in a large consecutive sample of patients with BD. METHOD: The study sample comprised of 347 patients who met DSM-IV-TR criteria for BD I (n=207, 59.7%), BD II or Cyclothymic Disorder (n=140, 40.3). Diagnostic information was collected by means of the Structured Clinical Interview for DSM-IV Axis I Disorders- Clinical Version (SCID-I), and information about personal and family history were collected by the Semi-Structured Interview for Mood Disorder-Revised (SIMD-R)...
January 1, 2015: Journal of Affective Disorders
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