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https://www.readbyqxmd.com/read/29346830/feasibility-of-navigable-percutaneous-disk-decompressor-l-disq-c-for-cervical-disk-herniation
#1
Youngki Hong, Seunghan Yoo, Nack Hwan Kim, Yushin Kim, Sangho Sohn, Sung-Young Yoon, Sangheon Lee
OBJECTIVE:  To assess the procedural efficacy and safety of a Navigable Percutaneous Disk Decompressor (L'DISQ-C) for cervical disk herniation. METHODS:  We performed intradiskal decompression on cervical spine specimens from five human cadavers using the L'DISQ-C under C-arm fluoroscopic guidance. We evaluated our success for positioning the navigable wand tip into the target region and recorded temperature variation at various distances from the wand tip in the cervical nucleus pulposus...
January 18, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29346733/synthesis-and-structure-activity-relationship-sar-studies-of-novel-pyrazolopyridine-derivatives-as-inhibitors-of-enterovirus-replication
#2
Yanpeng Xing, Jun Zuo, Paul Krogstad, Michael E Jung
A series of novel pyrazolopyridine compounds have been designed and prepared by a general synthetic route. Their activities against the replication of poliovirus-1, EV-A71, and CV-B3 enteroviruses were evaluated. The comprehensive understanding of the Structure-Activity Relationship was obtained by utilizing the variation of four positions, namely N1, C6, C4 and linker unit. From the screened analogues, the inhibitors with the highest selectivity indices at 50% inhibition of viral replication (SI50) were those with isopropyl at the N1 position and thiophenyl-2-yl unit at C6 position...
January 18, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29346414/reliability-of-plasma-polar-metabolite-concentrations-in-a-large-scale-cohort-study-using-capillary-electrophoresis-mass-spectrometry
#3
Sei Harada, Akiyoshi Hirayama, Queenie Chan, Ayako Kurihara, Kota Fukai, Miho Iida, Suzuka Kato, Daisuke Sugiyama, Kazuyo Kuwabara, Ayano Takeuchi, Miki Akiyama, Tomonori Okamura, Timothy M D Ebbels, Paul Elliott, Masaru Tomita, Asako Sato, Chizuru Suzuki, Masahiro Sugimoto, Tomoyoshi Soga, Toru Takebayashi
BACKGROUND: Cohort studies with metabolomics data are becoming more widespread, however, large-scale studies involving 10,000s of participants are still limited, especially in Asian populations. Therefore, we started the Tsuruoka Metabolomics Cohort Study enrolling 11,002 community-dwelling adults in Japan, and using capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography-mass spectrometry. The CE-MS method is highly amenable to absolute quantification of polar metabolites, however, its reliability for large-scale measurement is unclear...
2018: PloS One
https://www.readbyqxmd.com/read/29346096/iterative-graph-seeking-for-object-tracking
#4
Dawei Du, Longyin Wen, Honggang Qi, Qingming Huang, Qi Tian, Siwei Lyu
To effectively solve the challenges in object tracking, such as large deformation and severe occlusion, many existing methods use graph-based models to capture target part relations, and adopt a sequential scheme of target part selection, part matching, and state estimation. However, such methods have two major drawbacks: 1) inaccurate part selection leads to performance deterioration of part matching and state estimation and 2) there are insufficient effective global constraints for local part selection and matching...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29346094/reweighted-low-rank-matrix-analysis-with-structural-smoothness-for-image-denoising
#5
Hengyou Wang, Yigang Cen, Zhiquan He, Zhihai He, Ruizhen Zhao, Fengzhen Zhang
In this paper, we develop a new low-rank matrix recovery algorithm for image denoising. We incorporate the total variation (TV) norm and the pixel range constraint into the existing reweighted low-rank matrix analysis to achieve structural smoothness and to significantly improve quality in the recovered image. Our proposed mathematical formulation of the low-rank matrix recovery problem combines the nuclear norm, TV norm, and norm, thereby allowing us to exploit the low-rank property of natural images, enhance the structural smoothness, and detect and remove large sparse noise...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29345986/vital-signs-seismology-of-icy-ocean-worlds
#6
Steven D Vance, Sharon Kedar, Mark P Panning, Simon C Stähler, Bruce G Bills, Ralph D Lorenz, Hsin-Hua Huang, W T Pike, Julie C Castillo, Philippe Lognonné, Victor C Tsai, Alyssa R Rhoden
Ice-covered ocean worlds possess diverse energy sources and associated mechanisms that are capable of driving significant seismic activity, but to date no measurements of their seismic activity have been obtained. Such investigations could reveal the transport properties and radial structures, with possibilities for locating and characterizing trapped liquids that may host life and yielding critical constraints on redox fluxes and thus on habitability. Modeling efforts have examined seismic sources from tectonic fracturing and impacts...
January 2018: Astrobiology
https://www.readbyqxmd.com/read/29345956/measuring-three-dimensional-strain-and-structural-defects-in-a-single-ingaas-nanowire-using-coherent-x-ray-multi-angle-bragg-projection-ptychography
#7
Megan O Hill, Irene Calvo-Almazan, Mark Allain, Martin Holt, Andrew Ulvestad, Julian Treu, Gregor Koblmueller, Chunyi Huang, Xiaojing Huang, Hanfei Yan, E Nazarestski, Yong S Chu, G Brian Stephenson, Virginie Chamard, Lincoln Lauhon, Stephan O Hruszkewycz
III-As nanowires are candidates for near infrared light emitters and detectors that can be directly integrated onto silicon. However, nanoscale to microscale variations in structure, composition, and strain within a given nanowire, as well as variations between nanowires, pose challenges to correlating microstructure with device performance. In this work, we utilize coherent nano-focused x-rays to characterize stacking defects and strain in a single InGaAs nanowire supported on Si. By reconstructing diffraction patterns from the 2-1-10 Bragg peak, we show that the lattice orientation varies along the length of the wire, while the strain field along the cross-section is largely unaffected, leaving the band structure unperturbed...
January 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29345952/visible-light-enabled-preparation-of-palladium-nanoparticles-and-application-as-catalysts-for-suzuki-miyaura-coupling
#8
Florian Mäsing, Harald Nüsse, Jürgen Klingauf, Armido Studer
Silyl ketones were used for the preparation of palladium nanoparticles (PdNPs) starting with Pd(OAc)2 in dimethylformamide under irradiation with a visible light-emitting diode (LED). Variation of the silyl ketone structure allowed adjustment of the PdNP diameter (1.9 or 5.2 nm). The in situ-formed PdNPs were further stabilized with polyvinylpyrrolidone and then applied as recyclable catalysts in the Suzuki-Miyaura coupling of arylboronic acids with aryl iodides to obtain substituted biphenyls in excellent yields...
January 18, 2018: Organic Letters
https://www.readbyqxmd.com/read/29345744/land-surveys-show-regional-variability-of-historical-fire-regimes-and-structure-of-dry-forests-of-the-western-usa
#9
William L Baker, Mark A Williams
An understanding of how historical fire and structure in dry forests (ponderosa pine, dry mixed conifer) varied across the western USA remains incomplete. Yet, fire strongly affects ecosystem services, and forest restoration programs are underway. We used General Land Office survey reconstructions from the late-1800s across 11 landscapes covering ∼1.9 million ha in four states to analyze spatial variation in fire regimes and forest structure. We first synthesized the state of validation of our methods using 20 modern validations, 53 historical cross-validations, and corroborating evidence...
January 18, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29345719/an-anatomical-variant-evaluation-of-accessory-canals-of-the-canalis-sinuosus-using-cbct
#10
Kaan Orhan, Cansu Gorurgoz, Mesut Akyol, Savaş Ozarslanturk, Hakan Avsever
BACKGROUND: The anatomical variation of the anterior superior alveolar nerve which described as canalis sinuosus(CS) is a less known structure of anterior maxilla. Due to it contains anterior superior alveolar nerve as well as vein and arteries, exact diagnosis will provide surgeons to avoid complications. Hence, the aim of this study was to verify the presence, reveal the frequency and characteristics of accessory canals of canalis sinuosus. MATERIAL AND METHODS: This study was based on retrospective evaluation of CBCT scans...
January 18, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29345243/electronic-and-mechanical-response-of-graphene-on-batio-sub-3-sub-at-martensitic-phase-transitions
#11
Tim Verhagen, Vaclav Vales, Martin Kalbac, Jana Vejpravova
Graphene is extremely sensitive to optical, electrical and mechanical stimuli, which cause a significant variation of the band structure, thus physiochemical properties. In our work, we report on changes of strain and doping in graphene grown by chemical vapor deposition (CVD) and transferred onto a BaTiO3(100) (BTO) single-crystal. The BTO is known as a ferroelectric material, which undergoes several thermoelastic martensitic phase transitions when it is cooled from 300 K to 10K. In order to enhance the very weak Raman signal of the graphene monolayer (ML) on the BTO, a 15 nm thin gold layer was deposited on top of the graphene ML to benefit from the surface enhanced Raman scattering (SERS)...
January 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29344916/the-acute-effects-of-erythromycin-and-oxytetracycline-on-enhanced-biological-phosphorus-removal-system-shift-in-bacterial-community-structure
#12
Zhetai Hu, Peide Sun, Jingyi Han, Ruyi Wang, Liang Jiao, Pengfei Yang, Jing Cai
Since extensive application, an increasing amount of antibiotics has been released into wastewater treatment plants. In this study, the enhanced biological phosphorus removal (EBPR) system was fed with synthetic wastewater containing erythromycin (ERY) and oxytetracycline (OTC) for 7 days to evaluate the variations of solution ortho-P (SOP), volatile fatty acid (VFA), poly-bhydroxyalkanoates (PHAs), specific oxygen uptake rater (SOUR), and microbial community in the EBPR system. The obtained results showed that the P-removal efficiency decreased to 0...
January 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29343773/mitochondrial-mutations-in-cholestatic-liver-disease-with-biliary-atresia
#13
Hong Koh, Gun-Seok Park, Sun-Mi Shin, Chang Eon Park, Seung Kim, Seok Joo Han, Huy Quang Pham, Jae-Ho Shin, Dong-Woo Lee
Biliary atresia (BA) results in severe bile blockage and is caused by the absence of extrahepatic ducts. Even after successful hepatic portoenterostomy, a considerable number of patients are likely to show progressive deterioration in liver function. Recent studies show that mutations in protein-coding mitochondrial DNA (mtDNA) genes and/or mitochondrial genes in nuclear DNA (nDNA) are associated with hepatocellular dysfunction. This observation led us to investigate whether hepatic dysfunctions in BA is genetically associated with mtDNA mutations...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343583/structural-study-of-the-c-terminal-domain-of-non-structural-protein-1-from-japanese-encephalitis-virus
#14
Thanalai Poonsiri, Gareth S A Wright, Michael S Diamond, Lance Turtle, Tom Solomon, Svetlana V Antonyuk
Japanese encephalitis virus (JEV) is a mosquito-transmitted Flavivirus that is closely related to other emerging viral pathogens including dengue, West Nile (WNV) and Zika viruses. JEV infection can result in meningitis and encephalitis, which in severe cases cause permanent brain damage and death. JEV occurs predominantly in rural areas throughout Southeast Asia, the Pacific islands and the Far East, causing around 68,000 cases worldwide each year. In this study, we present a 2.1 Å resolution crystal structure of the C-terminal β-ladder domain of JEV non-structural protein 1 (NS1-C)...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29343561/geographical-range-size-and-latitude-predict-population-genetic-structure-in-a-global-survey
#15
Tara A Pelletier, Bryan C Carstens
While genetic diversity within species is influenced by both geographical distance and environmental gradients, it is unclear what other factors are likely to promote population genetic structure. Using a machine learning framework and georeferenced DNA sequences from more than 8000 species, we demonstrate that geographical attributes of the species range, including total size, latitude and elevation, are the most important predictors of which species are likely to contain structured genetic variation. While latitude is well known as an important predictor of biodiversity, our work suggests that it also plays a key role in shaping diversity within species...
January 2018: Biology Letters
https://www.readbyqxmd.com/read/29342357/diffusion-controlled-epitaxy-of-large-area-coalesced-wse2-monolayers-on-sapphire
#16
Xiaotian Zhang, Tanushree H Choudhury, Mikhail Chubarov, Yu Xiang, Bhakti Jariwala, Fu Zhang, Nasim Alem, Gwo-Ching Wang, Joshua A Robinson, Joan M Redwing
A multi-step diffusion-mediated process was developed to control the nucleation density, size and lateral growth rate of WSe2 domains on c-plane sapphire for the epitaxial growth of large area monolayer films by gas source chemical vapor deposition (CVD). The process consists of an initial nucleation step followed by an annealing period in H2Se to promote surface diffusion of tungsten-containing species to form oriented WSe2 islands with uniform size and controlled density. The growth conditions were then adjusted to suppress further nucleation and laterally grow the WSe2 islands to form a fully coalesced monolayer film in less than one hour...
January 17, 2018: Nano Letters
https://www.readbyqxmd.com/read/29342280/epigenetic-differentiation-of-natural-populations-of-lilium-bosniacum-associated-with-contrasting-habitat-conditions
#17
V Zoldoš, I Biruš, E Muratovic, Z Šatovic, A Vojta, O Robin, F Pustahija, F Bogunic, V Vicic Bockor, S Siljak-Yakovlev
Epigenetic variation in natural populations with contrasting habitats might be an important element, in addition to the genetic variation, in plant adaptation to environmental stress. Here, we assessed genetic, epigenetic and cytogenetic structure of the three Lilium bosniacum populations growing on distinct habitats. One population was growing under habitual ecological conditions for this species and the other two were growing under stress associated with high altitude and serpentine soil. Amplified fragment length polymorphism (AFLP) and methylation-sensitive amplification polymorphism (MSAP) analyses revealed that the three populations did not differentiate genetically, but were clearly separated in the three distinct clusters according to DNA methylation profiles...
January 12, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29341939/the-quest-for-equivalence-of-test-results-the-pilgrimage-of-the-dutch-calibration-2-000-program-for-metrological-traceability
#18
REVIEW
Rob T P Jansen, Christa M Cobbaert, Cas Weykamp, Marc Thelen
Calibration 2.000 was initiated 20 years ago for standardization and harmonization of medical tests. The program also intended to evaluate adequate implementation of the In Vitro Diagnostics (IVD) 98/79/EC directive, in order to ensure that medical tests are fit-for-clinical purpose. The Calibration 2.000 initiative led to ongoing verification of test standardization and harmonization in the Netherlands using commutable external quality assessment (EQA)-tools and a type 1 EQA-design, where feasible. National support was guaranteed by involving all laboratory professionals as well as laboratory technicians responsible for EQA and quality officers...
January 17, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29341616/stochasticity-of-pores-interconnectivity-in-li-o2-batteries-and-its-impact-on-the-variations-in-electrochemical-performance
#19
Amangeldi Torayev, José Alexis Rucci, Pieter M Magusin, Arnaud Demortiere, Vincent De Andrade, Clare P Grey, Céline Merlet, Alejandro A Franco
While large dispersions in electrochemical performance have been reported for lithium oxygen batteries in the literature, they have not been investigated in any depth. The variability in the results is often assumed to arise from differences in cell design, electrode structure, handling and cell preparation at different times. An accurate theoretical framework turns out to be needed to get a better insight into the mechanisms underneath and to interpreting experimental results. Here, we develop and use a pore network model to simulate the electrochemical performance of three-dimensionally resolved lithium-oxygen cathode mesostructures obtained from TXM nano-computed tomography images...
January 17, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29341588/human-neuraminidase-isoenzymes-show-variable-activities-for-9-o-acetyl-sialoside-substrates
#20
Carmanah D Hunter, Neha Khanna, Michele R Richards, Reza Rezaei Darestani, Chunxia Zou, John S Klassen, Christopher W Cairo
Recognition of terminal sialic acids is central to many cellular processes, and structural modification of sialic acid can disrupt these interactions. A prominent, naturally occuring, modification of sialic acid is 9-O-acetylation (9-O-Ac). Study of this modification through generation and analysis of 9-O-Ac sialosides is challenging due to the lability of the acetate group. Fundamental questions regarding the role of 9-O-Ac sialic acids remain unanswered, including what effect it may have on recognition and hydrolysis by the human neuraminidase enzymes (hNEU)...
January 17, 2018: ACS Chemical Biology
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