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https://www.readbyqxmd.com/read/30427564/effects-of-glial-glutamate-transporter-activator-in-formalin-induced-pain-behavior-in-mice
#1
Ghallab Alotaibi, Shafiqur Rahman
BACKGROUND: Nociceptive pain remains a prevalent clinical problem and often poorly responsive to the currently available analgesics. Previous studies have shown that astroglial glutamate transporter-1 (GLT-1) in the hippocampus and anterior cingulate cortex (ACC) is critically involved in pain processing and modulation. However, the role of astroglial GLT-1 in nociceptive pain involving the hippocampus and ACC remains unknown. We investigated the role of 3-[[(2-Methylphenyl) methyl]thio]-6-(2-pyridinyl)-pyridazine (LDN-212320), a GLT-1 activator, in nociceptive pain model and hippocampal-dependent behavioral tasks in mice...
November 14, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/30427506/medication-overuse-headache-retrospective-comparison-of-preventive-treatments
#2
Abouch V Krymchantowski, Ana Gabriela Ferreira Krymchantowski, Carla da Cunha Jevoux
OBJECTIVE: Medication-overuse headache is commonly seen in tertiary centers. Limited evidence is available regarding treatment. We compared the use of one or two drugs, three drugs, or four pharmacological agents for the prevention of headache. METHODS: This was a retrospective analysis of 149 consecutive patients. Sudden withdrawal and pharmacological prevention with one or more drugs were carried out. Adherence and the decrease of headache frequency of more than 50% were compared after four months between the one or two, three, and four drug groups...
October 2018: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/30427256/the-pull-of-soccer-and-the-push-of-xhosa-boys-in-an-hiv-and-drug-abuse-intervention-in-the-western-cape-south-africa
#3
Melissa Medich, Deborah Mindry, Mark Tomlinson, Mary Jane Rotheram-Borus, Jason Bantjes, Dallas Swendeman
There is growing interest in engaging men and boys in health and development programmes targeting the intersection of HIV risk, substance abuse, and violence. Understanding the conceptualisations of masculinities or masculine identities that shape both behaviours and opportunities for intervention is central to advancing the global agenda to engage men in health and development interventions. This paper examines an intervention using soccer and job training to engage and deliver activities for HIV prevention, substance abuse, and gender-based violence in a South African township...
December 2018: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
https://www.readbyqxmd.com/read/30427164/diabetic-ketoacidosis-following-peg-asparaginase-therapy
#4
Miriam Hinaa Ahmad, Ismat Shafiq
We report a case of a 21-year-old African American female with history of pre-diabetes, and a diagnosis of a rare leukemia, blastic-plasmacytoid dendritic neoplasm (BPDCN), who developed diabetic ketoacidosis (DKA) after the third dose of PEG-asparaginase infusion. She was successfully treated with insulin. Asparaginase is a vital part of treatment protocols for acute lymphoblastic leukemia (ALL) in combination with other chemotherapeutic drugs. Asparaginase therapy has been reported to cause hyperglycemia especially when used in conjunction with glucocorticoids for the treatment of ALL in the pediatric population...
October 31, 2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/30426714/intravenous-fosaprepitant-for-the-prevention-of-chemotherapy-induced-vomiting-in-children-a-double-blind-placebo-controlled-phase-iii-randomized-trial
#5
Venkatraman Radhakrishnan, Archit Joshi, Jaikumar Ramamoorthy, Swaminathan Rajaraman, Prasanth Ganesan, Trivadi S Ganesan, Manikandan Dhanushkodi, Tenali G Sagar
BACKGROUND: Fosaprepitant is a neurokinin-1 receptor antagonist, approved for the prevention of chemotherapy-induced nausea and vomiting. The data on the use of fosaprepitant in children are limited and therefore we conducted a phase III randomized controlled trial. PROCEDURE: Children aged 1-12 years scheduled to receive moderately or highly emetogenic chemotherapy were randomly assigned to arm-A (fosaprepitant) or arm-B (placebo). Children recruited to arm-A received intravenous ondansetron plus dexamethasone followed by fosaprepitant infusion...
November 13, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30426543/cepharanthine-suppresses-osteoclast-formation-by-modulating-the-nuclear-factor-%C3%AE%C2%BAb-and-nuclear-factor-of-activated-t-cell-signaling-pathways
#6
Xixi Lin, Fangming Song, Lin Zhou, Ziyi Wang, Chengming Wei, Jiake Xu, Jinmin Zhao, Qian Liu
The increased activation of osteoclasts is the major manifestation of several lytic bone diseases, including osteoporosis, rheumatoid arthritis, aseptic loosening of orthopedic implants, Paget disease and malignant bone diseases. One important bone-protective therapy in these diseases focuses on the inhibition of osteoclast differentiation and resorptive function. Given that the deleterious side-effects of currently available drugs, it is beneficial to search for effective and safe medications from natural compounds...
November 13, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30426478/basic-considerations-for-the-use-of-monoclonal-antibodies-in-migraine
#7
Morris Levin, Stephen D Silberstein, Robert Gilbert, Sylvia Lucas, Leanne Munsie, Alyssa Garrelts, Kate Kennedy, Nicole Everman, Eric Pearlman
BACKGROUND: The current study aimed to describe the impact of parental migraine on adolescent children (aged 11-17) living at home with a parent with migraine. AIM: Many drug classes are prescribed for migraine treatment, but all have limitations. Recently, calcitonin gene-related peptide (CGRP) activity has shown a significant promise as a target for preventive therapy. In this review, we provide an overview of the potential role of CGRP mAbs in migraine, with a focus on their design, pharmacokinetics, safety, and immunogenicity...
November 13, 2018: Headache
https://www.readbyqxmd.com/read/30426158/6-momipp-a-novel-brain-penetrant-anti-mitotic-indolyl-chalcone-inhibits-glioblastoma-growth-and-viability
#8
Shengnan Du, Jeffrey G Sarver, Christopher J Trabbic, Paul W Erhardt, Allen Schroering, William A Maltese
PURPOSE: 3-(6-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propene-1-one (6-MOMIPP) is a novel indole-based chalcone that disrupts microtubules. The present study aims to define the mechanism through which 6-MOMIPP induces cell death and to evaluate the efficacy of the compound in penetrating the blood-brain barrier and inhibiting growth of glioblastoma xenografts. METHODS: The effects of 6-MOMIPP were evaluated in cultured U251 glioblastoma cells, using viability, flow cytometry, and tubulin polymerization assays...
November 13, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/30426132/risk-factors-for-penile-intraepithelial-neoplasia-a-population-based-register-study-in-sweden-2000-2012
#9
Sinja Kristiansen, Åke Svensson, Linda Drevin, Ola Forslund, Christian Torbrand, Carina Bjartling
Studies on risk factors for penile intraepithelial neoplasia have been small in size, have not distinguished penile intraepithelial neoplasia from invasive cancer, and have relied on self-reported information. This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using information from 7 Swedish registers. Cases with penile intraepithelial neoplasia had increased odds ratios (ORs) for inflammatory skin diseases (14...
November 14, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/30425901/risk-and-protective-factors-for-drug-dependence-in-two-moroccan-high-risk-male-populations
#10
Anis Sfendla, Dina Lemrani, Britt Hedman Ahlström, Meftaha Senhaji, Nóra Kerekes
Background: Substance use is linked to biological, environmental, and social factors. This study provides insights on protective and risk factors for drug dependence in two Moroccan, high-risk, male samples. Methods: Data from the "Mental and Somatic Health without borders" (MeSHe) survey were utilized in the present study. The MeSHe survey assesses somatic and mental health parameters by self-report from prison inmates ( n = 177) and outpatients from an addiction institution ( n = 54)...
2018: PeerJ
https://www.readbyqxmd.com/read/30425782/an-overview-on-the-anti-inflammatory-potential-and-antioxidant-profile-of-eugenol
#11
REVIEW
Joice Nascimento Barboza, Carlos da Silva Maia Bezerra Filho, Renan Oliveira Silva, Jand Venes R Medeiros, Damião Pergentino de Sousa
The bioactive compounds found in foods and medicinal plants are attractive molecules for the development of new drugs with action against several diseases, such as those associated with inflammatory processes, which are commonly related to oxidative stress. Many of these compounds have an appreciable inhibitory effect on oxidative stress and inflammatory response, and may contribute in a preventive way to improve the quality of life through the use of a diet rich in these compounds. Eugenol is a natural compound that has several pharmacological activities, action on the redox status, and applications in the food and pharmaceutical industry...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30425653/repurposing-proteostasis-modifying-drugs-to-prevent-or-treat-age-related-dementia-a-systematic-review
#12
Daniel S Heard, Camilla S L Tuttle, Nicola T Lautenschlager, Andrea B Maier
Background: Dementia has a significant impact on quality of life of older individuals. Impaired proteostasis has been implicated as a potential cause of dementia, that can be therapeutically targeted to improve patient outcomes. This review aimed to collate all current evidence of the potential for targeting proteostasis with repurposed drugs as an intervention for age-related dementia and cognitive decline. Methods: PubMed, Web of Science and Embase databases were searched from inception until 4th July 2017 for studies published in English...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30425649/diabetic-cardiomyopathy-current-and-future-therapies-beyond-glycemic-control
#13
REVIEW
Giulia Borghetti, Dirk von Lewinski, Deborah M Eaton, Harald Sourij, Steven R Houser, Markus Wallner
Diabetes mellitus and the associated complications represent a global burden on human health and economics. Cardiovascular diseases are the leading cause of death in diabetic patients, who have a 2-5 times higher risk of developing heart failure than age-matched non-diabetic patients, independent of other comorbidities. Diabetic cardiomyopathy is defined as the presence of abnormal cardiac structure and performance in the absence of other cardiac risk factors, such coronary artery disease, hypertension, and significant valvular disease...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30425535/molecular-detection-of-rifampin-isoniazid-and-ofloxacin-resistance-in-iranian-isolates-of-mycobacterium-tuberculosis-by-high-resolution-melting-analysis
#14
Mehrandokht Sirous, Azar Dokht Khosravi, Mohammad Reza Tabandeh, Shokrollah Salmanzadeh, Nazanin Ahmadkhosravi, Sirus Amini
Background: The emergence of drug resistance among Mycobacterium tuberculosis (MTB) strains is a serious health concern worldwide. The development of rapid molecular diagnostic methods in recent years has a significant impact on the early detection of resistance to major anti-TB drugs in MTB isolates, which helps in employing appropriate treatment regimen and prevents the spread of drug-resistant strains. This study was designed to evaluate the efficacy of real-time PCR and high-resolution melting (HRM) curve analysis for the determination of resistance to rifampin (RIF), isoniazid (INH), and ofloxacin (OFX) in MTB isolates and to investigate their resistance-related mutations...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/30425497/violence-in-persons-with-and-without-psychosis-in-the-czech-republic-risk-and-protective-factors
#15
Martin Černý, Sheilagh Hodgins, Radmila Kučíková, Ladislav Kážmér, Alena Lambertová, Alexander Nawka, Lucie Nawková, Anna Parzelka, Jiří Raboch, Petr Bob, Jan Vevera
Purpose: To prevent violence among persons with psychosis, further knowledge of the correlates and risk factors is needed. These risk factors may vary by nation. Patients and methods: This study examined factors associated with violent assaults in 158 patients with psychosis and in a matched control sample of 158 adults without psychosis in the Czech Republic. Participants completed interviews and questionnaires to confirm diagnoses, report on aggressive behavior, current and past victimization, and substance use...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/30424732/biaryl-scaffold-focused-virtual-screening-for-anti-aggregatory-and-neuroprotective-effects-in-alzheimer-s-disease
#16
Sidra Khalid, Muhammad Ammar Zahid, Hussain Ali, Yeong S Kim, Salman Khan
BACKGROUND: Alzheimer's disease (AD) is a primary cause of dementia in ageing population affecting more than 35 million people around the globe. It is a chronic neurodegenerative disease caused by defected folding and aggregation of amyloid beta (Aβ) protein. Aβ is formed by the cleavage of membrane embedded amyloid precursor protein (APP) by using enzyme 'transmembrane aspartyl protease, β-secretase'. Inhibition of β-secretase is a viable strategy to prevent neurotoxicity in AD. Another strategy in the treatment of AD is inhibition of acetylcholinesterase...
November 13, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/30424727/hiv-prevalence-related-risk-behaviors-and-correlates-of-hiv-infection-among-people-who-use-drugs-in-cambodia
#17
Heng Sopheab, Chhorvann Chhea, Sovannary Tuot, Jonathan A Muir
BACKGROUND: Although HIV prevalence in Cambodia has declined to 0.6% among the general population, the prevalence remains high among female sex workers (14.0%) and men who have sex with men (2.3%). Over the past 10 years, the number of people who use drugs (PWUDs) has increased considerably. PWUDs, especially people who inject drugs (PWIDs), who have multiple sex partners or unprotected sex contribute to a higher HIV prevalence. This paper aims to estimate the prevalence of HIV across PWUD groups and to identify factors associated with HIV infection...
November 13, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30424484/pathogenic-viruses-commonly-present-in-the-oral-cavity-and-relevant-antiviral-compounds-derived-from-natural-products
#18
REVIEW
Daisuke Asai, Hideki Nakashima
Many viruses, such as human herpesviruses, may be present in the human oral cavity, but most are usually asymptomatic. However, if individuals become immunocompromised by age, illness, or as a side effect of therapy, these dormant viruses can be activated and produce a variety of pathological changes in the oral mucosa. Unfortunately, available treatments for viral infectious diseases are limited, because (1) there are diseases for which no treatment is available; (2) drug-resistant strains of virus may appear; (3) incomplete eradication of virus may lead to recurrence...
November 12, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/30424176/nanostructure-enabled-and-macromolecule-grafted-surfaces-for-biomedical-applications
#19
REVIEW
Madeline Small, Addison Faglie, Alexandra J Craig, Martha Pieper, Vivian E Fernand Narcisse, Pierre F Neuenschwander, Shih-Feng Chou
Advances in nanotechnology and nanomaterials have enabled the development of functional biomaterials with surface properties that reduce the rate of the device rejection in injectable and implantable biomaterials. In addition, the surface of biomaterials can be functionalized with macromolecules for stimuli-responsive purposes to improve the efficacy and effectiveness in drug release applications. Furthermore, macromolecule-grafted surfaces exhibit a hierarchical nanostructure that mimics nanotextured surfaces for the promotion of cellular responses in tissue engineering...
May 17, 2018: Micromachines
https://www.readbyqxmd.com/read/30423901/baseline-mapping-of-schistosomiasis-and-soil-transmitted-helminthiasis-in-the-northern-and-eastern-health-regions-of-gabon-central-africa-recommendations-for-preventive-chemotherapy
#20
Rodrigue Mintsa Nguema, Jacques F Mavoungou, Krystina Mengue Me Ngou-Milama, Modeste Mabicka Mamfoumbi, Aubin A Koumba, Mariama Sani Lamine, Abdoulaye Diarra, Ghislaine Nkone Asseko, Jean R Mourou, Marielle K Bouyou Akotet, Hélène Moné, Gabriel Mouahid, Julienne Atsame
In order to follow the Preventive Chemotherapy (PC) for the transmission control as recommended by WHO, Gabon initiated in 2014 the mapping of Schistosomiasis and Soil Transmitted Helminthiasis (STH). Here, we report the results of the Northern and Eastern health regions, representing a third of the land area and 12% of its total population. All nine departments of the two regions were surveyed and from each, five schools were examined with 50 schoolchildren per school. The parasitological examinations were realized using the filtration method for urine and the Kato-Katz technique for stool samples...
November 11, 2018: Tropical Medicine and Infectious Disease
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