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Cultural adaptation

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https://www.readbyqxmd.com/read/29778042/reliability-and-validity-of-the-dymus-questionnaire-for-the-assessment-of-dysphagia-in-multiple-sclerosis-greek-version-and-proposed-modification
#1
Athanasia Printza, Maria Kalaitzi, Christos Bakirtzis, Ioannis Nikolaidis, Hariklia Proios, Nikolaos Grigoriadis
BACKGROUND: Recent research confirmed that at least a third of people with multiple sclerosis (MS) are suffering from swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, and has profound impact on physical ability and quality of life. Dysphagia related complications can be prevented through an effective screening protocol. The Dysphagia in Multiple Sclerosis (DYMUS) questionnaire is the first dysphagia questionnaire developed specifically for patients with MS...
May 10, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29777860/cross-cultural-adaptation-and-validation-of-the-functional-assessment-of-chronic-illness-therapy-cervical-dysplasia-facit-cd-questionnaire-for-serbian-women
#2
Vesna Kesić, Radmila Sparić, Rafal Watrowski, Jelena Dotlić, Radomir Stefanović, Gorica Marić, Tatjana Pekmezović
OBJECTIVES: The FACIT-CD (Functional Assessment of Chronic Illness Therapy - Cervical Dysplasia) questionnaire is a disease-specific instrument for assessing the health-related quality of life (HRQoL) in women with cervical dysplasia. Our aim was to perform a cross-cultural adaptation and psychometric evaluation of the FACIT-CD scale in Serbian women with cervical squamous intraepithelial lesions (SIL). STUDY DESIGN: Our study included women of reproductive age diagnosed with SIL in a single university-affiliated hospital...
May 16, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29777590/boosting-mediated-electron-transfer-in-bioelectrochemical-systems-with-tailored-defined-microbial-co-cultures
#3
Simone Schmitz, Miriam A Rosenbaum
Bioelectrochemical systems (BES) hold great promise for sustainable energy generation via a microbial catalyst from organic matter, e.g., from wastewater. In order to improve current generation in BES, understanding the underlying microbiology of the electrode community is essential. Electron mediator producing microorganism like Pseudomonas aeruginosa play an essential role in efficient electricity generation in BES. These microbes enable even non-electroactive microorganism like Enterobacter aerogenes to contribute to current production...
May 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29777109/tak1-mediates-microenvironment-triggered-autocrine-signals-and-promotes-triple-negative-breast-cancer-lung-metastasis
#4
Oihana Iriondo, Yarong Liu, Grace Lee, Mostafa Elhodaky, Christian Jimenez, Lin Li, Julie Lang, Pin Wang, Min Yu
Triple-negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer that has limited therapeutic options. Thus, developing novel treatments for metastatic TNBC is an urgent need. Here, we show that nanoparticle-mediated delivery of transforming growth factor-β1-activated kinase-1 (TAK1) inhibitor 5Z-7-Oxozeaenol can inhibit TNBC lung metastasis in most animals tested. P38 is a central signal downstream of TAK1 in TNBC cells in TAK1-mediated response to multiple cytokines. Following co-culturing with macrophages or fibroblasts, TNBC cells express interleukin-1 (IL1) or tumor necrosis factor-α (TNFα), respectively...
May 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29776459/phycoremediation-of-municipal-wastewater-by-the-cold-adapted-microalga-monoraphidium-sp-dek19
#5
(no author information available yet)
Present municipal wastewater treatment technologies often require substantial energy inputs, and fail to completely remove nitrate and phosphate before discharging effluent. In contrast, utilizing the cold-adapted oleaginous microalga Monoraphidium sp. Dek 19 decreased levels of both these polluting ions to 0 mg/dl. Concurrent biomass production was greater at 10oC than at 22 oC, showing that phycoremediation occurred at low temperatures previously thought to be unsuitable for algal-based treatment. Algal growth with uptake of nitrate and phosphate required only short bursts of aeration to suspend cells and maintain CO2 supply for photosynthesis...
May 8, 2018: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/29776438/uninterrupted-monitoring-of-drug-effects-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-with-bioluminescence-ca-2-microscopy
#6
Kazushi Suzuki, Takahito Onishi, Chieko Nakada, Shunsuke Takei, Matthew J Daniels, Masahiro Nakano, Tomoki Matsuda, Takeharu Nagai
OBJECTIVE: Cardiomyocytes derived from human-induced pluripotent stem cells are a powerful platform for high-throughput drug screening in vitro. However, current modalities for drug testing, such as electrophysiology and fluorescence imaging have inherent drawbacks. To circumvent these problems, we report the development of a bioluminescent Ca2+ indicator GmNL(Ca2+ ), and its application in a customized microscope for high-throughput drug screening. RESULTS: GmNL(Ca2+ ) gives a 140% signal change with Ca2+ , and can image drug-induced changes of Ca2+ dynamics in cultured cells...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776341/different-adaptive-strategies-in-e-coli-populations-evolving-under-macronutrient-limitation-and-metal-ion-limitation
#7
Omar M Warsi, Dan I Andersson, Daniel E Dykhuizen
BACKGROUND: Adaptive responses to nutrient limitation involve mutations that increase the efficiency of usage or uptake of the limiting nutrient. However, starvation of different nutrients has contrasting effects on physiology, resulting in different evolutionary responses. Most studies performed to understand these evolutionary responses have focused only on macronutrient limitation. Hence our understanding of adaptation under limitation of other forms of nutrients is limited. In this study, we compared the evolutionary response in populations evolving under growth-limiting conditions for a macronutrient and a major cation...
May 18, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29775974/translation-and-cultural-adaptation-of-the-short-form-food-frequency-questionnaire-for-pregnancy-into-brazilian-portuguese
#8
Karina Tamy Kasawara, Daiane S M Paulino, Roberta Bgeginski, Chistine L Cleghorn, Michelle F Mottola, Fernanda Garanhani Surita
OBJECTIVE:  To translate and culturally adapt the short-form Food Frequency Questionnaire (SFFFQ) for pregnant women, which contains 24 questions, into Brazilian Portuguese. METHODS:  Description of the process of translation and cultural adaptation of the SFFFQ into Brazilian Portuguese. The present study followed the recommendation of the International Society for Pharmacoeconomics and Outcomes Research for translation and cultural adaptation with the following steps: 1) preparation; 2) first translation; 3) reconciliation; 4) back translation; 5) revision of back translation; 6) harmonization; 7) cognitive debriefing; 8) revision of debriefing results; 9) syntax and orthographic revision; and 10) final report...
May 18, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29775694/advance-care-planning-in-a-multi-cultural-family-centric-community-a-qualitative-study-of-healthcare-professionals-patients-and-caregivers-perspectives
#9
Sumytra Menon, Marijke Kars, Chetna Malhotra, Alastair V Campbell, J J M van Delden
CONTEXT: Advance care planning has been shown to improve end-of-life care but it was developed in the USA and most research has been conducted in western communities. OBJECTIVES: We aimed to study the attitudes and perceptions of patients with life-limiting illnesses, informal caregivers, doctors, nurses and medical social workers regarding advance care planning in a multi-cultural family-centric community. METHODS: We conducted an explorative qualitative study, using focus groups and individual in-depth interviews...
May 15, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29775474/the-cryptococcus-neoformans-titan-cell-is-an-inducible-and-regulated-morphotype-underlying-pathogenesis
#10
Ivy M Dambuza, Thomas Drake, Ambre Chapuis, Xin Zhou, Joao Correia, Leanne Taylor-Smith, Nathalie LeGrave, Tim Rasmussen, Matthew C Fisher, Tihana Bicanic, Thomas S Harrison, Marcel Jaspars, Robin C May, Gordon D Brown, Raif Yuecel, Donna M MacCallum, Elizabeth R Ballou
Fungal cells change shape in response to environmental stimuli, and these morphogenic transitions drive pathogenesis and niche adaptation. For example, dimorphic fungi switch between yeast and hyphae in response to changing temperature. The basidiomycete Cryptococcus neoformans undergoes an unusual morphogenetic transition in the host lung from haploid yeast to large, highly polyploid cells termed Titan cells. Titan cells influence fungal interaction with host cells, including through increased drug resistance, altered cell size, and altered Pathogen Associated Molecular Pattern exposure...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29775200/cadmium-induced-changes-in-the-production-of-siderophores-by-a-plant-growth-promoting-strain-of-pseudomonas-fulva
#11
Dominika Thiem, Michał Złoch, Renata Gadzała-Kopciuch, Sonia Szymańska, Christel Baum, Katarzyna Hrynkiewicz
The impact of increasing Cd2+ exposure on the quality and quantity of siderophores produced by a plant growth promoting Pseudomonas fulva strain was tested to gain insight into the degree of change. P. fulva was cultured in the increasing concentrations of Cd2+ (0, 0.5, 1.0, 2.0 mM). The secreted siderophores were separated by HPLC and characterized by UHPLC-QTOF/MS. In the presence of 2 mM Cd2+ synthesis of siderophores (hydroxamates, catecholates, phenolates) was mitigated compared to the treatments with lower concentrations of Cd2+ (0...
May 18, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29774801/therapists-perspectives-on-adapting-the-stepping-on-falls-prevention-programme-for-community-dwelling-stroke-survivors-in-singapore
#12
Tianma Xu, Kate O'loughlin, Lindy Clemson, Natasha A Lannin, Gerald Koh, Catherine Dean
PURPOSE: This study investigates the perspectives of rehabilitation therapists on the implementation of fall prevention programmes with community-dwelling stroke survivors in the Singapore context, and elicits recommendations to adapt the Stepping On programme with stroke survivors. METHOD: Qualitative data were elicited during 4 focus groups with 23 rehabilitation therapists (15 occupational therapists [OTs]; 8 physiotherapists [PTs]) who had received training to deliver the original Stepping On programme, and had experienced delivery of fall-prevention intervention programmes locally...
May 18, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29774124/long-term-exposure-to-carcinoma-associated-fibroblasts-makes-breast-cancer-cells-addictive-to-integrin-%C3%AE-1
#13
Angela Dittmer, Jürgen Dittmer
We studied the long-term effect of stromal factors on the development of fulvestrant-resistance (FR) and fulvestrant-induced dormancy (D). Sublines established from stroma-treated FR-cells (C-FR cells) and D-cells (C-D cells) show permanently high expression of integrin β1 as well as Bcl-3 and P-STAT3 (C-FR) or IGF1R (C-D). Yet, cells fail to withstand fulvestrant better and do not migrate or grow faster than control cells. Instead, C-D cells rely on stromal factors to perform as well as control cells. In addition, C-FR cells adapted to integrin β1 for growth in 3D cultures...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29772925/adjusted-linguistic-validation-and-psychometric-properties-of-the-colombian-version-of-kidscreen-52
#14
Mary Luz Jaimes-Valencia, Juana Perpiñá-Galvañ, Maria José Cabañero-Martínez, Julio Cabrero-García, Miguel Richart-Martínez
In health and clinical studies, health-related quality of life is often assessed using the well-established KIDSCREEN-52 questionnaires as well as the Vécu et Santé Perçue de l'Adolescent (VSP-A). The purpose of this study was twofold: to perform an adjusted linguistic validation of the Colombian version of the KIDSCREEN-52 and to assess its psychometric properties in children and adolescents. A total of 146 children and adolescents completed the KIDSCREEN-52, adolescents ( n = 48) additionally completed the VSP-A...
January 1, 2018: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29771748/personal-growth-attributed-by-nursing-students-to-a-diversity-class
#15
Ishan C Williams, Walter P Anderson, Sandra I Lopez-Baez
Although many nursing programs provide diversity training to enhance the understanding of cultural influences on health care, little is known about outcomes. This is due in part to a lack of consensus regarding definitions and measures. The purpose of this study was to examine a set of self-perceptions defined as personal growth, attributed by graduate nursing students (N = 41) to an eight-week diversity course. Participants reported modest levels of personal growth. Educators can adapt the instrument and method of this study to measure student attributions of growth to any aspect of nursing education...
May 16, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29770699/lysine-succinylation-and-acetylation-in-pseudomonas-aeruginosa
#16
Charlotte Gaviard, Isabelle Broutin, Pascal Cosette, Emmanuelle De, Thierry Jouenne, Julie Hardouin
Pseudomonas aeruginosa is a Multi-Drug Resistant human opportunistic pathogen largely involved in nosocomial infections. Unfortunately, effective antibacterial agents lacked. Explore its physiology at the post-translational modifications (PTMs) level may contribute to the renewal of combat tactics. Recently, lysine succinylation was discovered in bacteria and seems to be an interesting PTM. Here, we present the first succinylome and acetylome of P. aeruginosa PA14 cultured in the presence of 4 different carbon sources, using a two-dimensional immunoaffinity approach coupled with nano-liquid chromatograpy tandem mass spectrometry...
May 17, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29770550/improved-robustness-of-an-ethanologenic-yeast-strain-through-adaptive-evolution-in-acetic-acid-is-associated-with-its-enzymatic-antioxidant-ability
#17
N Gurdo, G F Novelli Poisson, Á B Juárez, M C Ríos de Molina, M A Galvagno
AIMS: To investigate multiple tolerance of Saccharomyces cerevisiae obtained through a laboratory strategy of adaptive evolution in acetic acid, its relation with enzymatic ROS detoxification and bioethanol 2G production. METHODS AND RESULTS: After adaptive evolution in acetic acid, a clone (Y8A) was selected for its tolerance to high acetic acid concentrations (13 g l-1 ) in batch cultures. Y8A was resistant to multiple stresses: osmotic, thermic, oxidative, saline, ethanol, organic acid, phenolic compounds and slow freeze-thawing cycles...
May 16, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29769543/the-cytokine-secretion-profile-of-mesenchymal-stromal-cells-is-determined-by-surface-structure-of-the-microenvironment
#18
Daniëlle G Leuning, Nick R M Beijer, Nadia A du Fossé, Steven Vermeulen, Ellen Lievers, Cees van Kooten, Ton J Rabelink, Jan de Boer
Mesenchymal stromal cells (MSC) secrete factors that contribute to organ homeostasis and repair in a tissue specific manner. For instance, kidney perivascular mesenchymal stromal cells (kPSCs) can facilitate renal epithelial repair through secretion of hepatocyte growth factor (HGF) while the secretome of bone marrow MSCs gives rise to immunosuppression. Stromal cells function in a complex 3-dimensional (3D) connective tissue architecture that induces conformational adaptation. Here we tested the hypothesis that surface topography and associated cell adaptations dictate stromal cell function through tuning of the cytokines released...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769399/dissecting-and-culturing-animal-cap-explants
#19
Kevin S Dingwell, James C Smith
The animal cap explant is a simple but adaptable tool available to developmental biologists. The use of animal cap explants in demonstrating the presence of mesoderm-inducting activity in the Xenopus embryo vegetal pole is one of many elegant examples of their worth. Animal caps respond to a range of growth factors (e.g., Wnts, FGF, TGF-β), making them especially useful for studying signal transduction pathways and gene regulatory networks. Explants are also suitable for examining cell behavior and have provided key insights into the molecular mechanisms controlling vertebrate morphogenesis...
May 16, 2018: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/29769316/the-serine-threonine-protein-kinase-endoribonuclease-ire1%C3%AE-protects-the-heart-against-pressure-overload-induced-heart-failure
#20
DeAnna Steiger, Tomohiro Yokota, Jin Li, Shuxun Ren, Susumu Minamisawa, Yibin Wang
Heart failure is associated with induction of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). The serine/threonine protein kinase/endoribonuclease IRE1α is a key protein in ER stress signal transduction. IRE1α activity can induce both protective UPR and apoptotic downstream signaling events, but the specific role for IRE1α activity in the heart is unknown. A major aim of this study was to characterize the specific contribution of IRE1α in cardiac physiology and pathogenesis. We used both cultured myocytes and a transgenic mouse line with inducible and cardiomyocyte-specific IRE1α overexpression as experimental models to achieve targeted IRE1α activation...
May 16, 2018: Journal of Biological Chemistry
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