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Cultural adaptation

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https://www.readbyqxmd.com/read/28723721/instrument-adaptation-modification-and-validation-for-cultural-beliefs-about-colorectal-cancer-screening-among-korean-americans
#1
Shin-Young Lee, Eunice E Lee, Frances Aranda
BACKGROUND: Studies on colorectal cancer (CRC) screening among Korean Americans (KAs) lack culturally sensitive, reliable, and validated belief scales. OBJECTIVE: The purpose of this study was to adapt, modify, and validate instruments measuring cultural beliefs (physical space, health temporal orientation, personal control, colon cancer fatalism, and health fatalism) about CRC screening in KAs. METHODS: In phase I, instrument adaptation and modification (translation from English into Korean, individual interviews using cognitive interviewing, and expert reviews) were used to make existing cultural beliefs instruments culturally appropriate for KAs...
July 14, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28720668/efficient-mitochondrial-glutamine-targeting-prevails-over-glioblastoma-metabolic-plasticity
#2
Kristell Oizel, Cynthia Chauvin, Lisa Oliver, Catherine Gratas, Fanny Geraldo, Ulrich Jarry, Emmanuel Scotet, Marion Rabe, Marie-Clotilde Alves-Guerra, Raluca Teusan, Fabien Gautier, Delphine Loussouarn, Vincent Compan, Jean-Claude Martinou, François M Vallette, Claire Pecqueur
Purpose Glioblastoma (GBM) is the most common and malignant form of primary human brain tumor in adults, with an average survival at diagnosis of 18 months. Metabolism is a new attractive therapeutic target in cancer, however, little is known about metabolic heterogeneity and plasticity within GBM tumors. We therefore aimed to investigate metabolic phenotyping of primary cultures in the context of molecular tumor heterogeneity to provide a proof-of concept for personalized metabolic targeting of GBM. <p> Experimental Design We have analyzed extensively several primary GBM cultures using transcriptomics, metabolic phenotyping assays and mitochondrial respirometry...
July 18, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28719365/proposed-model-for-the-cultural-adaptation-of-an-internet-based-depression-prevention-intervention-catch-it-for-arab-adolescents
#3
Zach Abuwalla, Zaynab Kadhem, Tracy Gladstone, Ereny Mikhael, Amir Bishay, Benjamin W Van Voorhees
Background Evidence-based Internet depression prevention intervention programs are not readily available for Arab youth, but may be effective in this group. Cultural adaptation of evidence-based Western psychotherapy is an important step toward better prevention and treatment of depressive illness in the Arab community. Project CATCH-IT is an Internet-based depression prevention intervention tool that is tailored for adolescents and young adults. Methods The PEN-3 theoretical framework was used for the cultural adaptation of Project CATCH-IT for Arab adolescents...
July 18, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28719070/sirtuin-1-attenuates-inflammation-and-hepatocellular-damage-in-liver-transplant-ischemia-reperfusion-from-mouse-to-human
#4
Kojiro Nakamura, Shoichi Kageyama, Bibo Ke, Takehiro Fujii, Rebecca A Sosa, Elaine F Reed, Nakul Datta, Ali Zarrinpar, Ronald W Busuttil, Jerzy W Kupiec-Weglinski
Hepatic ischemia-reperfusion injury (IRI), an inevitable antigen-independent inflammation response in cadaveric liver transplantation, correlates with poor early graft function, rejection episodes, and contributes to donor organ shortage. Sirtuin 1 (SIRT1) is a histone deacetylase which may regulate inflammatory cell activity and manage liver function in IRI, though its functional role and clinical relevance remains to be elucidated. We investigated the efficacy of SIRT1 activation in murine liver IRI model and verified the concept of putative SIRT1-mediated hepatoprotection in clinical liver transplantation...
July 18, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28716481/-disseminated-nocardiosis-caused-by-nocardia-nova-with-brain-abscesses-and-osteomyelitis-in-an-immunocompetent-patient
#5
P-L Conan, C Ficko, F Charton, O Bylicki, H Le Floch, J Margery, F Rivière
INTRODUCTION: Nocardia is an opportunist bacteria involved in patients with cellular immunodepression or chronic lung disease. The most frequent portals of entry are the respiratory tract by inhalation or direct inoculation through a cutaneous effraction. Nocardiosis may be localised or disseminated. CASE REPORT: We report a rare case of disseminated nocardiosis to Nocardia nova with pulmonary, cutaneous, cerebral attacks and femoral osteomyelitis. The diagnosis was confirmed by prolonged cultures of the bronchoalveolar fluid and the pus extracted from a cutaneous lesion...
July 14, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28716366/cross-cultural-adaptation-and-measurement-properties-of-the-brazilian-version-of-the-exercise-preference-questionnaire-stroke
#6
Lívia C G Caetano, Luci F Teixeira-Salmela, Giane A R Samora, Aline A Scianni
BACKGROUND: The Exercise Preference Questionnaire (EPQ(stroke)) captures exercise preferences and measures personal factors, that influence motivation and adherence to exercise in stroke subjects. OBJECTIVES: To perform the cross-cultural adaptation of the EPQ(stroke) into the Brazilian-Portuguese language and to evaluate its measurement properties. METHODS: The EPQ(stroke) was cross-culturally adapted and primarily tested in 30 chronic stroke subjects...
July 4, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28716084/development-and-validation-of-the-chinese-version-of-dry-eye-related-quality-of-life-scale
#7
Bang Zheng, Xiao-Jing Liu, Yue-Qian Fiona Sun, Jia-Zeng Su, Yang Zhao, Zheng Xie, Guang-Yan Yu
BACKGROUND: To develop the Chinese version of quality of life scale for dry eye patients based on the Impact of Dry Eye on Everyday Life (IDEEL) questionnaire and to assess the reliability and validity of the developed scale. METHODS: The original IDEEL was adapted cross-culturally to Chinese language and further developed following standard procedures. A total of 100 Chinese patients diagnosed with dry eye syndrome were included to investigate the psychometric properties of the Chinese version of scale...
July 17, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28715972/defensins-in-viral-infection-and-pathogenesis
#8
Mayumi K Holly, Karina Diaz, Jason G Smith
α, β, and ω defensins are effectors of the innate immune system with potent antibacterial, antiviral, and antifungal activity. Defensins have direct antiviral activity in cell culture, with varied mechanisms for individual viruses, although some common themes have emerged. In addition, defensins have potent immunomodulatory activity that can alter innate and adaptive immune responses to viral infection. In some cases, there is evidence for paradoxical escape from defensin neutralization or enhancement of viral infection...
July 17, 2017: Annual Review of Virology
https://www.readbyqxmd.com/read/28715919/lived-experiences-of-jordanian-mothers-caring-for-a-child-with-disability
#9
Mohammad S Nazzal, Omar M Al-Rawajfah
PURPOSE: Caring for a child with a disability in the family is associated with a major increase in care-giving demands and burden. This qualitative study explores the perspectives, challenges and adaptations of Jordanian mothers living with a child with disability. METHODS: Phenomenological qualitative tradition was utilized. Seven Jordanian mothers of children with disability were purposefully selected as having rich experiences for caring for a child with a disability...
July 18, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28714150/development-and-psychometric-testing-of-a-new-instrument-to-measure-the-caring-behaviour-of-nurses-in-italian-acute-care-settings
#10
Michela Piredda, Valerio Ghezzi, Elisa Fenizia, Anna Marchetti, Tommasangelo Petitti, Maria Grazia De Marinis, Alessandro Sili
AIM: To develop and psychometrically test the Italian-language Nurse Caring Behaviours Scale, a short measure of nurse caring behaviour as perceived by inpatients. BACKGROUND: Patient perceptions of nurses' caring behaviours are a predictor of care quality. Caring behaviours are culture-specific, but no measure of patient perceptions has previously been developed in Italy. Moreover, existing tools show unclear psychometric properties, are burdensome for respondents, or are not widely applicable...
July 16, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28713356/a-genotypic-analysis-of-five-p-aeruginosa-strains-after-biofilm-infection-by-phages-targeting-different-cell-surface-receptors
#11
Diana P Pires, Andreas Dötsch, Erin M Anderson, Youai Hao, Cezar M Khursigara, Joseph S Lam, Sanna Sillankorva, Joana Azeredo
Antibiotic resistance constitutes one of the most serious threats to the global public health and urgently requires new and effective solutions. Bacteriophages are bacterial viruses increasingly recognized as being good alternatives to traditional antibiotic therapies. In this study, the efficacy of phages, targeting different cell receptors, against Pseudomonas aeruginosa PAO1 biofilm and planktonic cell cultures was evaluated over the course of 48 h. Although significant reductions in the number of viable cells were achieved for both cases, the high level of adaptability of the bacteria in response to the selective pressure caused by phage treatment resulted in the emergence of phage-resistant variants...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28712988/the-spanish-adaptation-of-the-palliative-performance-scale-version-2-among-cancer-patients-at-the-end-of-life-psychometric-properties
#12
Eva Barallat, Maria Nabal, Jaume Canal, Javier Trujillano, Montse Gea-Sánchez, Philip J Larkin, Michael G Downing
BACKGROUND: Palliative Performance Scale (PPS) is a reliable tool to assess performance status in cancer patients receiving palliative care. Spanish validated and culturally adapted tools are needed. OBJECTIVES: To develop PPS translation and cross-cultural adaptation into Spanish. To assess its psychometric properties. DESIGN: Translation process with cross-cultural adaptation to produce Spanish Palliative Performance Scale (PPS-SPANISH)...
July 13, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28712937/returning-ex-patriot-chinese-to-guangdong-china-increase-the-risk-for-local-transmission-of-zika-virus
#13
Jiufeng Sun, De Wu, Haojie Zhong, Dawei Guan, Huan Zhang, Qiqi Tan, Huiqiong Zhou, Meng Zhang, Dan Ning, Baohuan Zhang, Changwen Ke, Tie Song, Jinyan Lin, Yonghui Zhang, Marion Koopmans, George F Gao
OBJECTIVES: Rapid transmission and linkage to microcephaly and Guillain-Barre syndrome have made Zika virus (ZIKV) infection become a serious threat to global public health. The epidemiology, virological characteristics and genetic evolution of introduced ZIKV to Guangdong, China, were investigated. METHODS: Analyses of the epidemiological characteristics and genetic diversity of ZIKV isolates were performed. RESULTS: Nineteen confirmed ZIKV infection cases were imported from Venezuela and Samoa...
July 14, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28712417/holding-the-body-in-mind-interoceptive-awareness-dispositional-mindfulness-and-psychological-well-being
#14
Adam W Hanley, Wolf E Mehling, Eric L Garland
Objective Recent dialogue between Western and Eastern traditions has stimulated novel explorations of the relationship between mind and body. Many of these cross-cultural, mind-body dialogues have proven productive in identifying more adaptive forms of embodiment. Prior studies suggest that dispositional mindfulness (DM) and interoceptive awareness (IA) are associated but distinct, key constructs in mind-body approaches that are conceptualized in a variety of ways with imprecisely characterized relationship...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28712382/design-and-fabrication-of-a-three-dimensional-in-vitro-system-for-modeling-vascular-stenosis
#15
Rebecca S Jones, Pin H Chang, Tzlil Perahia, Katrina A Harmon, Lorain Junor, Michael J Yost, Daping Fan, John F Eberth, Richard L Goodwin
Vascular stenosis, the abnormal narrowing of blood vessels, arises from defective developmental processes or atherosclerosis-related adult pathologies. Stenosis triggers a series of adaptive cellular responses that induces adverse remodeling, which can progress to partial or complete vessel occlusion with numerous fatal outcomes. Despite its severity, the cellular interactions and biophysical cues that regulate this pathological progression are poorly understood. Here, we report the design and fabrication of a three-dimensional (3D) in vitro system to model vascular stenosis so that specific cellular interactions and responses to hemodynamic stimuli can be investigated...
July 17, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28712352/national-overview-of-medication-assisted-treatment-for-american-indians-and-alaska-natives-with-substance-use-disorders
#16
Traci Rieckmann, Laurie Moore, Calvin Croy, Gregory A Aarons, Douglas K Novins
OBJECTIVE: American Indians and Alaska Natives (AI/ANs) experience higher rates of substance use disorders and less access to high-quality care compared with other racial-ethnic groups. The objective of this study was to better understand the use of medication-assisted treatment (MAT) of substance use disorders for AI/ANs and barriers to broader implementation. METHODS: Representatives of 192 substance abuse treatment programs completed a survey about their use of MAT...
July 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28712347/cultural-competence-a-framework-for-promoting-voluntary-medical-male-circumcision-among-varemba-communities-in-zimbabwe
#17
Kemist Shumba, Musara Lubombo
Almost a decade after the formal introduction of voluntary medical male circumcision (VMMC) as an important technology for HIV prevention, its implementation is still fraught with acceptability challenges. This is especially true among ethnic groups where male circumcision is conducted as a rite of passage into adulthood. In this article we question why VMMC is being met with resistance despite widespread awareness of its promise to reduce HIV incidence in a culturally circumcising community in Zimbabwe. In-depth and key informant interviews were conducted with selected VaRemba initiation graduates and surgeons respectively in Mposi area in Mberengwa to explore why VMMC has not been readily accepted in their community...
July 17, 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/28712160/perspectives-on-childhood-resilience-among-the-aboriginal-community-an-interview-study
#18
Christian Young, Allison Tong, Janice Nixon, Peter Fernando, Deanna Kalucy, Simone Sherriff, Kathleen Clapham, Jonathan C Craig, Anna Williamson
OBJECTIVE: To describe Aboriginal community members' perspectives on the outcomes and origins of resilience among Aboriginal children. METHODS: Face-to-face interviews were conducted with 36 Aboriginal adults (15 health service professionals, 8 youth workers and 13 community members) at two urban and one regional Aboriginal Community Controlled Health Service in New South Wales. Interviews were transcribed and analysed thematically. RESULTS: We identified six themes: withstanding risk (displaying normative development, possessing inner fortitude); adapting to adversity (necessary endurance, masking inner vulnerabilities); positive social influences (secure family environments, role modelling healthy behaviours and relationships); instilling cultural identity (investing in Aboriginal knowledge, building a strong cultural self-concept); community safeguards (offering strategic sustainable services, holistic support, shared responsibility, providing enriching opportunities); and personal empowerment (awareness of positive pathways, developing self-respect, fostering positive decision making)...
July 16, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28711317/invasion-fitness-for-gene-culture-co-evolution-in-family-structured-populations-and-an-application-to-cumulative-culture-under-vertical-transmission
#19
Charles Mullon, Laurent Lehmann
Human evolution depends on the co-evolution between genetically determined behaviors and socially transmitted information. Although vertical transmission of cultural information from parent to offspring is common in hominins, its effects on cumulative cultural evolution are not fully understood. Here, we investigate gene-culture co-evolution in a family-structured population by studying the invasion fitness of a mutant allele that influences a deterministic level of cultural information (e.g., amount of knowledge or skill) to which diploid carriers of the mutant are exposed in subsequent generations...
July 12, 2017: Theoretical Population Biology
https://www.readbyqxmd.com/read/28710767/rapid-detection-of-%C3%AE-h2av-foci-in-ex-vivo-mms-treated-drosophila-imaginal-discs
#20
Varandt Y Khodaverdian, Mitch McVey
In Drosophila melanogaster, DNA double-strand breaks (DSBs) created by exposure to gamma or X-ray radiation can be quantified by immunofluorescent detection of phosphorylated histone H2Av (γ-H2Av) foci in imaginal disc tissues. This technique has been less useful for studying DSBs in imaginal discs exposed to DSB-inducing chemicals, since standard protocols require raising larvae in food treated with liquid chemical suspensions. These protocols typically take 3-4 days to complete and result in heterogeneous responses that do not provide information about the kinetics of DSB formation and repair...
2017: Methods in Molecular Biology
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