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https://www.readbyqxmd.com/read/28634286/conjugate-vaccine-immunotherapy-for-substance-use-disorder
#1
REVIEW
Paul T Bremer, Kim D Janda
Substance use disorder, especially in relation to opioids such as heroin and fentanyl, is a significant public health issue and has intensified in recent years. As a result, substantial interest exists in developing therapeutics to counteract the effects of abused drugs. A promising universal strategy for antagonizing the pharmacology of virtually any drug involves the development of a conjugate vaccine, wherein a hapten structurally similar to the target drug is conjugated to an immunogenic carrier protein...
July 2017: Pharmacological Reviews
https://www.readbyqxmd.com/read/28634058/apoptotic-gene-expression-profiles-and-dna-damage-levels-in-rat-liver-treated-with-perfluorooctane-sulfonate-and-protective-role-of-curcumin
#2
Dilek Eke, Ayla Çelik, Bertan Yilmaz, Nurcan Aras, Sabriye Kocatürk Sel, Davut Alptekin
Perfluorinated compounds (PFCs) such as PFOS and PFOA, are xenobiotics that can be detected worldwide in the environment and humans. PFOS (C8F17SO3(-)) is a fluorinated organic compound has been used for decades in industrial and commercial products. We investigated the genotoxic and apoptotic impact of PFOS in rat liver using comet assay, micronucleus test and apoptotic gene expression methods for caspase 3, caspase 8 and the protective role of curcumin on the PFOS- induced damage under chronic exposure. In this study, rats were treated either with three different PFOS doses only (0...
June 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28632490/the-florence-statement-on-triclosan-and-triclocarban
#3
Rolf U Halden, Avery E Lindeman, Allison E Aiello, David Andrews, William A Arnold, Patricia Fair, Rebecca E Fuoco, Laura A Geer, Paula I Johnson, Rainer Lohmann, Kristopher McNeill, Victoria P Sacks, Ted Schettler, Roland Weber, R Thomas Zoeller, Arlene Blum
The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban. These chemicals may be used in thousands of personal care and consumer products as well as in building materials. Based on extensive peer-reviewed research, this statement concludes that triclosan and triclocarban are environmentally persistent endocrine disruptors that bioaccumulate in and are toxic to aquatic and other organisms...
June 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28632097/the-moderating-effect-of-neighborhood-sense-of-community-on-predictors-of-substance-use-among-hispanic-urban-youth
#4
David T Lardier, Marisa MacDonnell, Veronica R Barrios, Pauline Garcia-Reid, Robert J Reid
Hispanic adolescents represent a disproportionate number of youth living in urban communities. These youth confront significant social problems that increase their likelihood for substance use. However, youth that have a greater neighborhood sense of community are postulated, through empowerment theory, to be less influenced by negative environmental experiences and less inclined to engage in drug and alcohol use. We examine the moderating effect neighborhood SOC has on predictors of substance use among Hispanic (N = 538) urban youth in low- (n = 246) and high-conflict homes (n = 292)...
February 26, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28630556/how-drug-control-policy-and-practice-undermine-access-to-controlled-medicines
#5
Naomi Burke-Shyne, Joanne Csete, Duncan Wilson, Edward Fox, Daniel Wolfe, Jennifer J K Rasanathan
Drug conventions serve as the cornerstone for domestic drug laws and impose a dual obligation upon states to prevent the misuse of controlled substances while ensuring their adequate availability for medical and scientific purposes. Despite the mandate that these obligations be enforced equally, the dominant paradigm enshrined in the drug conventions is an enforcement-heavy criminal justice response to controlled substances that prohibits and penalizes their misuse. Prioritizing restrictive control is to the detriment of ensuring adequate availability of and access to controlled medicines, thereby violating the rights of people who need them...
June 2017: Health and Human Rights
https://www.readbyqxmd.com/read/28629861/flavonoids-determine-the-rate-of-fibrillogenesis-and-structure-of-collagen-type-i-fibrils-in-vitro
#6
Yuri A Kim, Yury S Tarahovsky, Sergei G Gaidin, Elena A Yagolnik, Eugeny N Muzafarov
Collagen fibrils are produced from collagen monomers not only in vivo, but also in vitro. The ability to have an influence on the structure and properties of fibrils may find medical application and can be useful for controlling the formation of collagen gels and sheets in tissue engineering. Here we investigated the influence of flavonoids, distinguished by the number of hydroxyl groups in the B-ring, on the formation of collagen fibrils. A correlation was found between the number of hydroxyl groups, lipophilicity of molecules and their ability to influence the fibril formation...
June 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28629352/male-suicide-among-construction-workers-in-australia-a-qualitative-analysis-of-the-major-stressors-precipitating-death
#7
Allison Milner, Humaira Maheen, Dianne Currier, Anthony D LaMontagne
BACKGROUND: Suicide rates among those employed in male-dominated professions such as construction are elevated compared to other occupational groups. Thus far, past research has been mainly quantitative and has been unable to identify the complex range of risk and protective factors that surround these suicides. METHODS: We used a national coronial database to qualitatively study work and non-work related influences on male suicide occurring in construction workers in Australia...
June 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28627395/the-opioid-epidemic-is-an-historic-opportunity-to-improve-both-prevention-and-treatment
#8
Robert L DuPont
The current narrative describing the national opioid epidemic as the result of overprescribing opioid pain medicines fails to capture the full dimensions of problem and leads to inadequate and even confounding solutions. Overlooked is the fact that polysubstance use is nearly ubiquitous among overdose deaths, demonstrating that the opioid overdose death problem is bigger than opioids. The foundation of the nation's opioid overdose crisis - and the totality of the nation's drug epidemic - is widespread recreational pharmacology, the use of drugs for fun or "self-medication...
June 13, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28624776/mold-control-and-detection-in-biological-drug-substance-manufacturing-facilities-an-industry-perspective
#9
Anita Bawa, Sophia Asefi, Stephanie Ramsey, Christine Arbesser-Rastburg, Mousumi Paul, Francisco Leira, Kim McFarland, Tracy Landeryou, Bindhu Reddy, Marie Murphy, Barbara Daddis, David Baine, Derek Willison-Parry
The biopharmaceutical industry produces non-sterile and/or low-bioburden intermediates and bulk biologics (i.e. Drug Substances) using bioburden controlled processes in accordance to Q7A and Annex 2. In many cases, single mold isolation events have received a high level of scrutiny; the goal of this paper is to challenge this paradigm and provide the rationale for an enhanced control approach that focuses on trending of mold species as microbial indicators rather than on single isolation events. Molds, can also be part (in much lower numbers) of the normal microbial population of a biologics manufacturing facility and, therefore, mold isolation is not an unexpected event in non-aseptic processing environments...
June 16, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/28624106/alcohol-use-and-smoking-after-liver-transplantation-complications-and-prevention
#10
REVIEW
José Ursic-Bedoya, Hélène Donnadieu-Rigole, Stéphanie Faure, Georges-Philippe Pageaux
The last thirty years have been very prosperous in the field of liver transplantation (LT), with great advances in organ conservation, surgical techniques, peri-operative management and long-term immunosuppression, resulting in improved patient and graft survival rates as well as quality of life. However, substance addiction after LT, namely alcohol and tobacco, results in short term morbidity together with medium and long-term mortality. The main consequences can be vascular (increased risk of hepatic artery thrombosis in smokers), hepatic (recurrent alcoholic cirrhosis in alcohol relapsers) and oncological (increased risk of malignancy in patients consuming tobacco and/or alcohol after LT)...
April 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28622407/challenges-and-lessons-learned-in-implementing-a-community-academic-partnership-for-drug-prevention-in-a-native-hawaiian-community
#11
Susana Helm, Kanoelani Davis, Anonymous Youth Participants Haumana
OBJECTIVE: The broad purpose of this project is to improve health in Native Hawaiian communities through the prevention of substance use. Our community-academic partnership (CAP) team developed an intervention called Puni Ke Ola for this purpose. This paper provides a brief overview of the intervention, then describes challenges and lessons learned in piloting Puni Ke Ola. METHODS: A single module of the Puni Ke Ola intervention was implemented, after which the intervention leaders (N=3) convened for a debriefing meeting...
June 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28622403/using-network-sampling-and-recruitment-data-to-understand-social-structures-related-to-community-health-in-a-population-of-people-who-inject-drugs-in-rural-puerto-rico
#12
Mayra Coronado-García, Courtney R Thrash, Melissa Welch-Lazoritz, Robin Gauthier, Juan Carlos Reyes, Bilal Khan, Kirk Dombrowski
OBJECTIVE: This research examined the social network and recruitment patterns of a sample of people who inject drugs (PWIDs) in rural Puerto Rico, in an attempt to uncover systematic clustering and between-group social boundaries that potentially influence disease spread. METHODS: Respondent driven sampling was utilized to obtain a sample of PWID in rural Puerto Rico. Through eight initial "seeds", 317 injection drug users were recruited. Using recruitment patterns of this sample, estimates of homophily and affiliation were calculated using RDSAT...
June 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28622100/prevalence-of-substance-use-among-middle-school-aged-e-cigarette-users-compared-with-cigarette-smokers-non-users-and-dual-users-implications-for-primary-prevention
#13
Alfgeir L Kristjansson, Michael J Mann, Megan L Smith
BACKGROUND: To compare the prevalence of substance use in e-cigarette (EC) only users with combustible cigarette (CC) only users, dual users, and non-users in a large sample of middle school-aged adolescents. METHODS: Population-based cross-sectional school survey conducted in 15 middle schools in three counties in West Virginia in the US between October and December of 2015 (N = 6,547, girls = 49.6%. Response rate 84.7%). RESULTS: Approximately 4...
June 16, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28621447/metformin-prevents-vascular-prostanoid-release-alterations-induced-by-a-high-fat-diet-in-rats
#14
H J Lee, S M Cantú, A S Donoso, M R Choi, H A Peredo, A M Puyó
Perivascular adipose tissue dysfunction induced by high-fat feeding leads to alterations in the modulation of inflammation, contractile activity of the vascular smooth muscle and endothelial function, all risk factors in the development of hypertension. Metformin, an activator of AMP-activated protein kinase (AMPK), is currently the first-line drug treatment for type 2 diabetes (T2DM) and metabolic syndrome. Besides its glucose-lowering effect, there is an interest in actions of this drug with potential relevance in cardiovascular diseases...
June 16, 2017: Autonomic & Autacoid Pharmacology
https://www.readbyqxmd.com/read/28620722/testing-the-amotivational-syndrome-marijuana-use-longitudinally-predicts-lower-self-efficacy-even-after-controlling-for-demographics-personality-and-alcohol-and-cigarette-use
#15
Andrew Lac, Jeremy W Luk
The marijuana amotivational syndrome posits that cannabis use fosters apathy through the depletion of motivation-based constructs such as self-efficacy. The current study pursued a two-round design to rule out concomitant risk factors responsible for the connection from marijuana intake to lower general self-efficacy. College students (N = 505) completed measures of marijuana use, demographics (age, gender, and race), personality (extraversion, agreeableness, conscientiousness, openness, and neuroticism), other substance use (alcohol and tobacco), and general self-efficacy (initiative, effort, and persistence) in two assessments separated by a month...
June 16, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28620324/description-of-various-factors-contributing-to-traffic-accidents-in-youth-and-measures-proposed-to-alleviate-recurrence
#16
REVIEW
Ludovic Gicquel, Pauline Ordonneau, Emilie Blot, Charlotte Toillon, Pierre Ingrand, Lucia Romo
Traffic accidents are the leading cause of hospitalization in adolescence, with the 18-24-year-old age group accounting for 23% of deaths by traffic accidents. Recurrence rate is also high. One in four teenagers will have a relapse within the year following the first accident. Cognitive impairments known in adolescence could cause risky behaviors, defined as repetitive engagement in dangerous situations such as road accidents. Two categories of factors seem to be associated with traffic accidents: (1) factors specific to the traffic environment and (2) "human" factors, which seem to be the most influential...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28619532/major-physical-health-conditions-and-risk-of-suicide
#17
Brian K Ahmedani, Edward L Peterson, Yong Hu, Rebecca C Rossom, Frances Lynch, Christine Y Lu, Beth E Waitzfelder, Ashli A Owen-Smith, Samuel Hubley, Deepak Prabhakar, L Keoki Williams, Nicole Zeld, Elizabeth Mutter, Arne Beck, Dennis Tolsma, Gregory E Simon
INTRODUCTION: Most individuals make healthcare visits before suicide, but many do not have a diagnosed mental health condition. This study seeks to investigate suicide risk among patients with a range of physical health conditions in a U.S. general population sample and whether risk persists after adjustment for mental health and substance use diagnoses. METHODS: This study included 2,674 individuals who died by suicide between 2000 and 2013 along with 267,400 controls matched on year and location in a case-control study conducted in 2016 across eight Mental Health Research Network healthcare systems...
June 7, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28619114/reducing-the-rate-and-duration-of-re-admissions-among-patients-with-unipolar-disorder-and-bipolar-disorder-using-smartphone-based-monitoring-and-treatment-the-radmis-trials-study-protocol-for-two-randomized-controlled-trials
#18
Maria Faurholt-Jepsen, Mads Frost, Klaus Martiny, Nanna Tuxen, Nicole Rosenberg, Jonas Busk, Ole Winther, Jakob Eyvind Bardram, Lars Vedel Kessing
BACKGROUND: Unipolar and bipolar disorder combined account for nearly half of all morbidity and mortality due to mental and substance use disorders, and burden society with the highest health care costs of all psychiatric and neurological disorders. Among these, costs due to psychiatric hospitalization are a major burden. Smartphones comprise an innovative and unique platform for the monitoring and treatment of depression and mania. No prior trial has investigated whether the use of a smartphone-based system can prevent re-admission among patients discharged from hospital...
June 15, 2017: Trials
https://www.readbyqxmd.com/read/28618267/enhancement-of-ifn%C3%AE-production-by-distinct-commensals-ameliorates-salmonella-induced-disease
#19
Sophie Thiemann, Nathiana Smit, Urmi Roy, Till Robin Lesker, Eric J C Gálvez, Julia Helmecke, Marijana Basic, Andre Bleich, Andrew L Goodman, Ulrich Kalinke, Richard A Flavell, Marc Erhardt, Till Strowig
The microbiota contributes to colonization resistance against invading pathogens by competing for metabolites, producing inhibitory substances, and priming protective immune responses. However, the specific commensal bacteria that promote host resistance and immune-mediated protection remain largely elusive. Using isogenic mouse lines with distinct microbiota profiles, we demonstrate that severity of disease induced by enteric Salmonella Typhimurium infection is strongly modulated by microbiota composition in individual lines...
June 14, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28617075/follow-up-of-young-adults-with-adhd-in-the-mta-design-and-methods-for-qualitative-interviews
#20
Thomas S Weisner, Desiree W Murray, Peter S Jensen, John T Mitchell, James M Swanson, Stephen P Hinshaw, Karen Wells, Lily Hechtman, Brooke S G Molina, L Eugene Arnold, Page Sorensen, Annamarie Stehli
OBJECTIVE: Qualitative interviews with 183 young adults (YA) in the follow-up of the Multimodal Treatment Study of Children With and Without ADHD (MTA) provide rich information on beliefs and expectations regarding ADHD, life's turning points, medication use, and substance use (SU). METHOD: Participants from four MTA sites were sampled to include those with persistent and atypically high SU, and a local normative comparison group (LNCG). Respondents were encouraged to "tell their story" about their lives, using a semistructured conversational interview format...
June 1, 2017: Journal of Attention Disorders
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