keyword
https://read.qxmd.com/read/38520605/pioneering-the-way-the-revolutionary-potential-of-antibody-drug-conjugates-in-nsclc
#21
REVIEW
Xiehui Chen, Changchun Zeng
Despite targeted therapy and immunotherapy being recognized as established frontline treatments for advanced non-small cell lung cancer (NSCLC), the unavoidable development of resistance and disease progression poses ongoing challenges. Antibody-drug conjugates (ADCs) offer a potent treatment option for NSCLC through the specific delivery of cytotoxic agents to tumor cells that display distinct antigens. This review delves into the latest evidence regarding promising ADC agents for NSCLC, focusing on their targets, effectiveness, and safety assessments...
March 23, 2024: Current Treatment Options in Oncology
https://read.qxmd.com/read/38520356/utilizing-magnetic-levitation-to-detect-lung-cancer-associated-exosomes
#22
JOURNAL ARTICLE
Alper Baran Sözmen, Ahu Arslan-Yildiz
Extracellular vesicles, especially exosomes, have attracted attention in the last few decades as novel cancer biomarkers. Exosomal membrane proteins provide easy-to-reach targets and can be utilized as information sources of their parent cells. In this study, a MagLev-based, highly sensitive, and versatile biosensor platform for detecting minor differences in the density of suspended objects is proposed for exosome detection. The developed platform utilizes antibody-functionalized microspheres to capture exosomal membrane proteins (ExoMPs) EpCAM, CD81, and CD151 as markers for cancerous exosomes, exosomes, and non-small cell lung cancer (NSCLC)-derived exosomes, respectively...
March 23, 2024: ACS Sensors
https://read.qxmd.com/read/38518054/g2-and-s-phase-expressed-protein-1-is-a-biomarker-for-poor-prognosis-in-lung-adenocarcinoma
#23
JOURNAL ARTICLE
Xitong Yang, Xiaoling Zhu
Studying the regulatory mechanism and clinical application of G2 and S phase-expressed protein 1 (GTSE1) genes in lung adenocarcinoma (LUAD). LUAD data was obtained from The Cancer Genome Atlas (TCGA) database, and differentially expressed genes (DEGs) were derived by analyzing expression data using R software. Survival analysis was performed to identify genes associated with LUAD, and among them, a target gene for LUAD was identified. Further analysis of the gene expression profiling interactive analysis database revealed differences in gene expression between normal and tumor tissues of LUAD patients...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517880/causal-role-of-metabolites-in-non-small-cell-lung-cancer-mendelian-randomization-mr-study
#24
JOURNAL ARTICLE
Qian Li, Zedong Wei, Yonglun Zhang, Chongqing Zheng
On a global scale, lung cancer(LC) is the most commonly occurring form of cancer. Nonetheless, the process of screening and detecting it in its early stages presents significant challenges. Earlier research endeavors have recognized metabolites as potentially reliable biomarkers for LC. However, the majority of these studies have been limited in scope, featuring inconsistencies in terms of the relationships and levels of association observed.Moreover, there has been a lack of consistency in the types of biological samples utilized in previous studies...
2024: PloS One
https://read.qxmd.com/read/38517827/lung-cancer-biomarkers-raising-the-clinical-value-of-the-classical-and-the-new-ones
#25
EDITORIAL
Stefan Holdenrieder, Huub H van Rossum, Michel van den Heuvel
Blood-based diagnostics for lung cancer support the diagnosis, estimation of prognosis, prediction, and monitoring of therapy response in lung cancer patients. The clinical utility of serum tumor markers has considerably increased due to developments in serum protein tumor markers analytics and clinical biomarker studies, the exploration of preanalytical and influencing conditions, the interpretation of biomarker combinations and individual biomarker kinetics, as well as the implementation of biostatistical models...
2024: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://read.qxmd.com/read/38517815/nme6-as-a-potential-biomarker-and-therapeutic-target-involved-in-immune-infiltration-for-lung-adenocarcinoma
#26
JOURNAL ARTICLE
Linjie Luo, Ying Li, Lin Zhang, Lijie Yang
BACKGROUND: Lung adenocarcinoma (LUAD), a prevalent form of lung cancer, is characterized by its high global mortality rate. Previous studies have demonstrated the significance of Nucleoside diphosphate kinase (NME) in various cancers; however, the specific role of NME6 in LUAD remains inadequately understood. OBJECTIVE: This research aims to enhance our understanding of LUAD by investigating the expression level, epigenetic mechanism, signaling activities, and immune infiltrating characteristic immune cells of NME6 in patients...
February 29, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38517780/curating-retrospective-multimodal-and-longitudinal-data-for-community-cohorts-at-risk-for-lung-cancer
#27
JOURNAL ARTICLE
Thomas Z Li, Kaiwen Xu, Neil C Chada, Heidi Chen, Michael Knight, Sanja Antic, Kim L Sandler, Fabien Maldonado, Bennett A Landman, Thomas A Lasko
BACKGROUND: Large community cohorts are useful for lung cancer research, allowing for the analysis of risk factors and development of predictive models. OBJECTIVE: A robust methodology for (1) identifying lung cancer and pulmonary nodules diagnoses as well as (2) associating multimodal longitudinal data with these events from electronic health record (EHRs) is needed to optimally curate cohorts at scale. METHODS: In this study, we leveraged (1) SNOMED concepts to develop ICD-based decision rules for building a cohort that captured lung cancer and pulmonary nodules and (2) clinical knowledge to define time windows for collecting longitudinal imaging and clinical concepts...
March 7, 2024: Cancer Biomarkers: Section A of Disease Markers
https://read.qxmd.com/read/38517776/a-novel-disulfidptosis-related-prognostic-gene-signature-and-experimental-validation-identify-actn4-as-a-novel-therapeutic-target-in-lung-adenocarcinoma
#28
JOURNAL ARTICLE
Kai Xie, Bin Wang, Pei Pang, Guangbin Li, Qianqian Yang, Chen Fang, Wei Jiang, Yu Feng, Haitao Ma
BACKGROUND: Lung adenocarcinoma (LUAD) is a prevalent form of malignancy globally. Disulfidptosis is novel programmed cell death pathway based on disulfide proteins, may have a positive impact on the development of LUAD treatment strategies. OBJECTIVE: To investigate the impact of disulfidptosis-related genes (DRGs) on the prognosis of LUAD, developed a risk model to facilitate the diagnosis and prognostication of patients. We also explored ACTN4 (DRGs) as a new therapeutic biomarker for LUAD...
February 12, 2024: Cancer Biomarkers: Section A of Disease Markers
https://read.qxmd.com/read/38515725/knowledge-domains-and-emerging-trends-in-immune-related-adverse-events-from-immune-checkpoint-inhibitors-a-bibliometrics-and-visualized-analysis
#29
JOURNAL ARTICLE
Jun Zhao, Yujie Feng, Guang-Wei Liu
OBJECTIVE: The primary objective of this paper is to investigate the research hotspots and future trends of immune-related adverse events induced by immune checkpoint inhibitors, offering valuable insights for researchers in this field. METHODOLOGY: Using the visual analysis software, this study conducted quantitative statistics and visualization research on the relevant literature concerning immune-related adverse events caused by immune checkpoint inhibitors in the Web of Science Core Collection Database...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38515565/ferroptosis-in-lung-cancer-dual-role-multi-level-regulation-and-new-therapeutic-strategies
#30
REVIEW
Yunbin Li, Xiaosong Li, Jian Li
Lung cancer is a highly prevalent malignant tumor worldwide, with high incidence and death rates. Recently, there has been increasing recognition of the role of ferroptosis, a unique cell death mechanism, in lung cancer. This review aims to summarize the current research progress on the relationship between ferroptosis and lung cancer. It also provides a comprehensive analysis of the regulatory processes of ferroptosis in various stages, including epigenetics, transcription, post-transcription, translation, and post-translation...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38515178/auranofin-repurposing-for-lung-and-pancreatic-cancer-low-ca12-expression-as-a-marker-of-sensitivity-in-patient-derived-organoids-with-potentiated-efficacy-by-akt-inhibition
#31
JOURNAL ARTICLE
Christophe Deben, Laurie Freire Boullosa, Felicia Rodrigues Fortes, Edgar Cardenas De La Hoz, Maxim Le Compte, Sofie Seghers, Marc Peeters, Steve Vanlanduit, Abraham Lin, Krijn K Dijkstra, Paul Van Schil, Jeroen M H Hendriks, Hans Prenen, Geert Roeyen, Filip Lardon, Evelien Smits
BACKGROUND: This study explores the repurposing of Auranofin (AF), an anti-rheumatic drug, for treating non-small cell lung cancer (NSCLC) adenocarcinoma and pancreatic ductal adenocarcinoma (PDAC). Drug repurposing in oncology offers a cost-effective and time-efficient approach to developing new cancer therapies. Our research focuses on evaluating AF's selective cytotoxicity against cancer cells, identifying RNAseq-based biomarkers to predict AF response, and finding the most effective co-therapeutic agents for combination with AF...
March 22, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38514598/revealing-a-novel-methylated-integrin-alpha-8-related-to-extracellular-matrix-and-anoikis-resistance-using-proteomic-analysis-in-the-immune-microenvironment-of-lung-adenocarcinoma
#32
JOURNAL ARTICLE
Tingting Liu, Wen Ji, Xue Cheng, Lin Lv, Xiaohui Yu, Na Wang, Mengcong Li, Tinghua Hu, Zhihong Shi
Genomic epigenetics of extracellular matrix (ECM) play an important role in lung adenocarcinoma (LUAD). Our study identified a signature of potential prognostic genes associated with ECM and constructed immune risk-related prognosis model in LUAD. We downloaded mRNAs transcriptome data, miRNAs expression data, and clinical patient information for LUAD based on The Cancer Genome Atlas. "Limma, clusterProfiler, ggplot2" R packages and GSEA were used to analyze meaningful genes and explore potential biological function...
March 21, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38513890/high-throughput-antigen-microarray-identifies-longitudinal-prognostic-autoantibody-for-chemoimmunotherapy-in-advanced-non-small-cell-lung-cancer
#33
JOURNAL ARTICLE
Liyuan Dai, Qiaoyun Tan, Lin Li, Ning Lou, Cuiling Zheng, Jianliang Yang, Liling Huang, Shasha Wang, Rongrong Luo, Guangyu Fan, Tongji Xie, Jiarui Yao, Zhishang Zhang, Le Tang, Yuankai Shi, Xiaohong Han
Chemoimmunotherapy has evolved as a standard treatment for advanced non-small cell lung cancer (aNSCLC). However, inevitable drug resistance has limited its efficacy, highlighting the urgent need for biomarkers of chemoimmunotherapy. A three-phase strategy to discover, verify, and validate longitudinal predictive autoantibodies (AAbs) for aNSCLC before and after chemoimmunotherapy was employed. A total of 528 plasma samples from 267 aNSCLC patients before and after anti-PD1 immunotherapy were collected, plus 30 independent formalin-fixed paraffin-embedded samples...
March 19, 2024: Molecular & Cellular Proteomics: MCP
https://read.qxmd.com/read/38513140/pd1-inhibits-pkc%C3%AE-dependent-phosphorylation-of-cytoskeleton-related-proteins-and-immune-synapse-formation
#34
JOURNAL ARTICLE
Daniela Chmiest, Silvia Podavini, Kalliopi Ioannidou, David Vallois, Chantal Décaillet, Montserrat Gonzalez, Manfredo Quadroni, Kevin Blackney, Rebekka Schairer, Laurence L de Leval, Margot Thome
The inhibitory cell surface receptor programmed death 1 (PD1) is a major target for antibody-based cancer immunotherapies. Nevertheless, a substantial number of patients fail to respond to the treatment or experience adverse effects. An improved understanding of intracellular pathways targeted by PD1 is thus needed to develop better predictive and prognostic biomarkers. Here, via unbiased phosphoproteome analysis of primary human T cells, we demonstrate that PD1 triggering inhibited the phosphorylation and physical association with PKC theta (PKCof a variety of cytoskeleton-related proteins...
March 21, 2024: Blood Advances
https://read.qxmd.com/read/38509870/hypoxic-exosomal-circplekhm1-mediated-crosstalk-between-tumor-cells-and-macrophages-drives-lung-cancer-metastasis
#35
JOURNAL ARTICLE
Dongliang Wang, Shuoer Wang, Mingming Jin, Yan Zuo, Jianpeng Wang, Ya Niu, Qian Zhou, Jiwei Chen, Xinru Tang, Wenxuan Tang, Xiyu Liu, Hang Yu, Wangjun Yan, Huan-Huan Wei, Gang Huang, Shaoli Song, Shuang Tang
Intercellular communication often relies on exosomes as messengers and is critical for cancer metastasis in hypoxic tumor microenvironment. Some circular RNAs (circRNAs) are enriched in cancer cell-derived exosomes, but little is known about their ability to regulate intercellular communication and cancer metastasis. Here, by systematically analyzing exosomes secreted by non-small cell lung cancer (NSCLC) cells, a hypoxia-induced exosomal circPLEKHM1 is identified that drives NSCLC metastasis through polarizing macrophages toward to M2 type...
March 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38508285/dual-specificity-tyrosine-regulated-kinase-2-exerts-anti-tumor-effects-by-induction-of-g1-arrest-in-lung-adenocarcinoma
#36
JOURNAL ARTICLE
Eriko Harada, Saishu Yoshida, Yuta Imaizumi, Akira Kawamura, Takashi Ohtsuka, Kiyotsugu Yoshida
OBJECTIVES: Lung cancer is a leading cause of cancer-related mortality and remains one of the most poorly prognosed disease worldwide. Therefore, it is necessary to identify novel molecular markers with potential therapeutic effects. Recent findings have suggested that dual-specificity tyrosine-regulated kinase 2 (DYRK2) plays a tumor suppressive role in colorectal, breast, and hepatic cancers; however, its effect and mechanism in lung cancer remain poorly understood. Therefore, this study aimed to investigate the tumor-suppressive role and molecular mechanism of DYRK2 in lung adenocarcinoma (LUAD) by in vitro experiments and xenograft models...
March 18, 2024: Biochimica et Biophysica Acta. General Subjects
https://read.qxmd.com/read/38508094/serum-iron-element-a-novel-biomarker-for-predicting-pd-1-immunotherapy-efficacy
#37
REVIEW
Fang Luan, Jingliang Wang, Lei Liu, Bin Liu, Fuxia Li, Jing Zhao, Jingjiang Lai, Fengxian Jiang, Wei Xu, Zhizhao Zhang, Pancen Ran, Yang Shu, Zhe Yang, Guobin Fu
This study aims to explore the relationship between serum iron by inductively coupled plasma-mass spectrometry (ICP-MS) and the efficacy of immune checkpoint inhibitors (ICIs) and potential mechanism. Totally 113 patients from 233 patients with advanced metastatic lung cancer, esophageal cancer, gastric cancer and colorectal cancer who treated with immunotherapy in Shandong Provincial Hospital were divided into training group (n=68) and validation group (n=45), whose patients were divided into clinical benefit response (CBR) and non-clinical benefit (NCB) by RECIST (v1...
March 18, 2024: International Immunopharmacology
https://read.qxmd.com/read/38508055/cogspro-net-a-graph-neural-network-based-on-protein-protein-interaction-for-classifying-lung-cancer-relatrd-proteins
#38
JOURNAL ARTICLE
Wei Wei, Dongsheng Yue
This paper proposes a deep learning algorithm named CoGSPro for classifying lung cancer-related proteins. CoGSPro combines graph neural networks and attention mechanisms to extract key features from protein data and accurately classify proteins. It utilizes large-scale protein expression datasets to train and validate the model, enabling it to identify subtle patterns related to lung cancer. CoGSPro integrates protein-protein interaction network information to improve its predictive accuracy. The experimental results indicate that CoGSPro achieves cutting-edge performance, attaining an accuracy of 96...
March 13, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38507877/hepatotoxicity-in-patients-with-non-small-cell-lung-cancer-treated-with-sotorasib-after-prior-immunotherapy-a-comprehensive-clinical-and-pharmacokinetic-analysis
#39
JOURNAL ARTICLE
Sophie M Ernst, Maaike M Hofman, Tessa E van der Horst, Marthe S Paats, Frank W J Heijboer, Joachim G J V Aerts, Daphne W Dumoulin, Robin Cornelissen, Jan H von der Thüsen, Peter de Bruijn, Esther Oomen-de Hoop, Ron H J Mathijssen, Stijn L W Koolen, Anne-Marie C Dingemans
BACKGROUND: Sotorasib given after immunotherapy could put patients at increased risk of hepatotoxicity. Therefore, there is a need to gain insight into the potential correlation between anti-PD-(L)1 treatment, anti-PD-(L)1 concentrations, sotorasib concentrations, and the incidence of hepatotoxicity during sotorasib. METHODS: Patients with KRASG12C -mutated NSCLC treated with sotorasib were prospectively enrolled in our biomarker cohort study (NCT05221372). Plasma samples were collected prior and during sotorasib treatment for anti-PD-1 and sotorasib concentrations...
March 19, 2024: EBioMedicine
https://read.qxmd.com/read/38506751/projecting-the-impact-of-multi-cancer-early-detection-on-late-stage-incidence-using-multi-state-disease-modeling
#40
JOURNAL ARTICLE
Jane M Lange, Kemal Caglar Gogebakan, Roman Gulati, Ruth Etzioni
BACKGROUND: Downstaging- reduction in late-stage incidence-has been proposed as an endpoint in randomized trials of multi-cancer early detection (MCED) tests. How downstaging depends on test performance and follow-up has been studied for some cancers but is understudied for cancers without existing screening and for MCED tests that include these cancer types. METHODS: We develop a model for cancer natural history that can be fit to registry incidence patterns under minimal inputs and can be estimated for solid cancers without existing screening...
March 20, 2024: Cancer Epidemiology, Biomarkers & Prevention
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