Dongliang Wang, Shuoer Wang, Mingming Jin, Yan Zuo, Jianpeng Wang, Ya Niu, Qian Zhou, Jiwei Chen, Xinru Tang, Wenxuan Tang, Xiyu Liu, Hang Yu, Wangjun Yan, Huan-Huan Wei, Gang Huang, Shaoli Song, Shuang Tang
Intercellular communication often relies on exosomes as messengers and is critical for cancer metastasis in hypoxic tumor microenvironment. Some circular RNAs (circRNAs) are enriched in cancer cell-derived exosomes, but little is known about their ability to regulate intercellular communication and cancer metastasis. Here, by systematically analyzing exosomes secreted by non-small cell lung cancer (NSCLC) cells, a hypoxia-induced exosomal circPLEKHM1 is identified that drives NSCLC metastasis through polarizing macrophages toward to M2 type...
March 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)