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JOURNAL ARTICLE
L Xiu, N Li, W P Wang, F Chen, G W Yuan, Y C Sun, R Zhang, X G Li, J Zuo, N Li, W Cui, L Y Wu
Objective: To explore the serum cyclic polypeptide biomarkers for ovarian cancer diagnosis. Methods: A total of 54 patients with epithelial ovarian cancer confirmed by pathology in Cancer Hospital, Chinese Academy of Medical Sciences from March 2018 to September 2018 were selected as the study subjects, and 40 healthy women with normal examination results in the cancer screening center were selected as the control. All of the samples were randomly divided into training set and validation set at the ratio of 1∶1 with a random number...
November 23, 2021: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
#22
REVIEW
Marissa L Maciej-Hulme
In this review, the current experimental evidence, literature and hypotheses surrounding hyaluronidase 4 [HYAL4, also known as chondroitin sulphate hydrolase (CHSE)] and chondroitin sulphate (CS) are explored. Originally named for its sequence similarity to other members of the hyaluronidase family, HYAL4 is actually a relatively distinct member of the family, particularly for its unique degradation of CS-D (2- O -, 6- O -sulphated CS) motifs and specific expression. Human HYAL4 protein expression and structural features are discussed in relation to different isoforms, activities, potential localisations and protein-protein interaction partners...
2021: Frontiers in Cell and Developmental Biology
#23
JOURNAL ARTICLE
Yunfei He, Dongdong Cheng, Cheng Lian, Yingjie Liu, Wenqian Luo, Yuan Wang, Chengxin Ma, Qiuyao Wu, Pu Tian, Dasa He, Zhenchang Jia, Xianzhe Lv, Xue Zhang, Zhen Pan, Jinxi Lu, Yansen Xiao, Peiyuan Zhang, Yajun Liang, Qingcheng Yang, Guohong Hu
Giant cell tumor of bone (GCTB) is an aggressive osteolytic bone tumor characterized by the within-tumor presence of osteoclast-like multinucleated giant cells (MGCs), which are induced by the neoplastic stromal cells and lead to extensive bone destruction. However, the underlying mechanism of the pathological process of osteoclastogenesis in GCTB is poorly understood. Here we show that the proteoglycan Serglycin (SRGN) secreted by neoplastic stromal cells plays a crucial role in the formation of MGCs and tumorigenesis in GCTB...
September 23, 2021: Cell Death & Disease
#24
JOURNAL ARTICLE
Ichidai Tanaka, Delphine Dayde, Mei Chee Tai, Haruki Mori, Luisa M Solis, Satyendra C Tripathi, Johannes F Fahrmann, Nese Unver, Gargy Parhy, Rekha Jain, Edwin R Parra, Yoshiko Murakami, Clemente Aguilar-Bonavides, Barbara Mino, Muge Celiktas, Dilsher Dhillon, Julian Phillip Casabar, Masahiro Nakatochi, Francesco Stingo, Veera Baladandayuthapani, Hong Wang, Hiroyuki Katayama, Jennifer B Dennison, Philip L Lorenzi, Kim-Anh Do, Junya Fujimoto, Carmen Behrens, Edwin J Ostrin, Jaime Rodriguez-Canales, Tetsunari Hase, Takayuki Fukui, Taisuke Kajino, Seiichi Kato, Yasushi Yatabe, Waki Hosoda, Koji Kawaguchi, Kohei Yokoi, Toyofumi F Chen-Yoshikawa, Yoshinori Hasegawa, Adi F Gazdar, Ignacio I Wistuba, Samir Hanash, Ayumu Taguchi
BACKGROUND: Approximately 20% of lung adenocarcinoma (LUAD) is negative for the lineage-specific oncogene Thyroid transcription factor 1 (TTF-1) and exhibits worse clinical outcome with a low frequency of actionable genomic alterations. To identify molecular features associated with TTF-1-negative LUAD, we compared the transcriptomic and proteomic profiles of LUAD cell lines. SRGN , a chondroitin sulfate proteoglycan Serglycin, was identified as a markedly overexpressed gene in TTF-1-negative LUAD...
February 7, 2022: Journal of the National Cancer Institute
#25
JOURNAL ARTICLE
Bin Lv, Guangyu Gao, Yuhong Guo, Zhiping Zhang, Renfeng Liu, Zhengzai Dai, Cheng Ju, Yiping Liang, Xiaofeng Tang, Min Tang, Xiao-Bin Lv
BACKGROUND: Osteosarcoma (OS) is a common disease in the world, and its pathogenesis is still unclear. This study aims to identify the key genes that promote the proliferation, invasion, and metastasis of osteosarcoma cells. METHOD: GSE124768 and GSE126209 were downloaded from the Gene Expression Omnibus (GEO) database. The gene ontology and enrichment pathway were analyzed by FunRich software. qPCR and Western blot were used to detect the gene expression. After gene knockdown, Transwell and wound healing assays were conducted on osteosarcoma cells to detect whether the genes were defined before enhancing the invasion of osteosarcoma...
September 7, 2021: Aging
#26
JOURNAL ARTICLE
Haorong Qin, Xiaoming Li, Jian Wang, Guobo Sun, Xiaohui Mu, Rongchao Ji
Xupu goose, a breed from Hunan province, produces high quality and quantity of meat and liver. However, its egg production rate is low, with poor reproductive traits but strong broody performance. These characteristics decrease the economic value of Xupu goose significantly. Here, RNA-seq was used to analyze the transcriptome changes of ovaries of Xupu goose at different stages to explore the molecular mechanism of reproduction from the pre-laying period to the broody period. A total of 258 genes were differentially expressed in the 3 stages...
July 24, 2021: Poultry Science
#27
REVIEW
Yun Zhu, Annie Lai Man Cheung
Esophageal squamous cell carcinoma (ESCC) is a highly malignant disease that has a poor prognosis. Its high lethality is mainly due to the lack of symptoms at early stages, which culminates in diagnosis at a late stage when the tumor has already metastasized. Unfortunately, the common cancer biomarkers have low sensitivity and specificity in esophageal cancer. Therefore, a better understanding of the molecular mechanisms underlying ESCC progression is needed to identify novel diagnostic markers and therapeutic targets for intervention...
July 24, 2021: World Journal of Clinical Oncology
#28
JOURNAL ARTICLE
Zhiqiang Li, Dimitra Peirasmaki, Staffan Svärd, Magnus Åbrink
The proteoglycan serglycin (SG) is expressed by different innate and adaptive immune cells, e.g. mast cells, macrophages, neutrophils, and cytotoxic T lymphocytes, where SG contributes to correct granule storage and extracellular activity of inflammatory mediators. Here the serglycin-deficient (SG-/- ) mouse strain was used to investigate the impact of SG on intestinal immune responses during infection with the non-invasive protozoan parasite Giardia intestinalis . Young (≈11 weeks old) oral gavage-infected congenic SG-/- mice showed reduced weight gain as compared with the infected SG+/+ littermate mice and the PBS-challenged SG-/- and SG+/+ littermate mice...
2021: Frontiers in Immunology
#29
JOURNAL ARTICLE
Burcu Ugurlu Ilgın, Emrullah Kızıltunç, Murat Gök, Ender Ornek, Canan Topcuoglu, Mustafa Çetin, Orhan Karayiğit
BACKGROUND: It is suggested that serglycin has important functions in fibrin stabilization and inflammation but there is limited information on its clinical value for atherosclerotic heart disease. OBJECTIVE: The purpose of this study is to find out serum serglycin levels in acute myocardial infarction patients and in the control group individuals; and to investigate the association between serglycin levels with inflammation markers and infarct size markers. METHODS: The study population consisted of 75 patients with ST-segment elevation myocardial infarction (STEMI) and 57 patients with normal coronary arteries (NCA) (control group)...
April 2021: Arquivos Brasileiros de Cardiologia
#30
JOURNAL ARTICLE
Junqi Xie, Xiaofeng Qi, Yufeng Wang, Xiteng Yin, Wenguang Xu, Shengwei Han, Yu Cai, Wei Han
BACKGROUND: The tumor microenvironment (TME) is known to play a prominent role in the pathology of head and neck squamous cell carcinoma (HNSCC). Cancer-associated fibroblasts (CAFs) have been reported to regulate tumor progression, and serglycin (SRGN), one of the paracrine cytokines of CAFs, has been reported to play an important role in various signaling pathways. Hypoxia is a distinct feature of the HNSCC TME. Here, we investigated the mechanism underlying CAF-secreted SRGN leading to HNSCC progression under hypoxia...
March 2, 2021: Cellular Oncology (Dordrecht)
#31
JOURNAL ARTICLE
Dimitra Manou, Panagiotis Bouris, Dimitris Kletsas, Martin Götte, Burkhard Greve, Aristidis Moustakas, Nikos K Karamanos, Achilleas D Theocharis
Despite the functional role of serglycin as an intracellular proteoglycan, a variety of malignant cells depends on its expression and constitutive secretion to advance their aggressive behavior. Serglycin arose to be a biomarker for glioblastoma, which is the deadliest and most treatment-resistant form of brain tumor, but its role in this disease is not fully elucidated. In our study we suppressed the endogenous levels of serglycin in LN-18 glioblastoma cells to decipher its involvement in their malignant phenotype...
May 2020: Matrix biology plus
#32
JOURNAL ARTICLE
Yun Zhu, Alfred K Y Lam, Daisy K Y Shum, Di Cui, Jun Zhang, Dong Dong Yan, Bin Li, Wen Wen Xu, Nikki P Y Lee, Kin Tak Chan, Simon Law, Sai Wah Tsao, Annie L M Cheung
Rationale : Little is known about the roles of proteoglycans in esophageal cancer. This study aims to investigate the roles and mechanisms of serglycin (SRGN) proteoglycan in promoting metastasis of esophageal squamous cell carcinoma (ESCC). Methods : Reverse phase protein array analysis was used to identify activated signaling pathways in SRGN -overexpressing cells. Chemokine array was used to identify differentially secreted factors from SRGN -overexpressing cells. Binding between SRGN and potential interacting partners was evaluated using proximity ligation assay and co-immunoprecipitation...
2021: Theranostics
#33
JOURNAL ARTICLE
Harry Chanzu, Joshua Lykins, Subershan Wigna-Kumar, Smita Joshi, Irina Pokrovskaya, Brian Storrie, Gunnar Pejler, Jeremy P Wood, Sidney W Whiteheart
BACKGROUND: Serglycin (SRGN) is an intragranular, sulfated proteoglycan in hematopoietic cells that affects granule composition and function. OBJECTIVE: To understand how SRGN affects platelet granule packaging, cargo release, and extra-platelet microenvironments. METHODS: Platelets and megakaryocytes from SRGN-/- mice were assayed for secretion kinetics, cargo levels, granule morphology upon activation, and receptor shedding. RESULTS: Metabolic, 35 SO4 labeling identified SRGN as a major sulfated macromolecule in megakaryocytes...
April 2021: Journal of Thrombosis and Haemostasis: JTH
#34
JOURNAL ARTICLE
Layi Wang, Yin Han, Xiajun Wang
BACKGROUND: Diabetic retinopathy (DR), a microvascular complication which is closely related to diabetes, remains the leading cause of vision loss around the world among older adults. Serglycin (SRGN) was known as a hematopoietic cell granule proteoglycan, exerting its function in the formation of mast cell secretory granules and mediates the storage of various compounds in secretory vesicles. The present study illustrates the potential clinical value and experimental mechanisms of SRGN in the DR...
December 12, 2020: Journal of Clinical Laboratory Analysis
#35
JOURNAL ARTICLE
Yue Li, Hongjie Chen, Huiqiong Lu, Zengcheng Zou, Yongwei Li
AIM AND OBJECTIVE: Inflammation-related changes in peripheral blood cells and blood proteins are prognostic factors for survival in hepatocellular carcinoma (HCC), but their usefulness is limited by an active bacterial infection. This study investigated whether infection interfered with the predictive value of serglycin, a proteoglycan found in hematopoietic cells, on survival in HCC. MATERIALS AND METHODS: Patients with hepatitis B virus (HBV)-induced HCC, 100 without and 30 with a bacterial infection, and 30 healthy adult controls were enrolled retrospectively...
2021: Combinatorial Chemistry & High Throughput Screening
#36
JOURNAL ARTICLE
Rangita Dawadi, Nabin Malla, Beate Hegge, Imin Wushur, Eli Berg, Gunbjørg Svineng, Ingebrigt Sylte, Jan-Olof Winberg
Previous studies have shown that THP-1 cells produced an SDS-stable and reduction-sensitive complex between proMMP-9 and a chondroitin sulfate proteoglycan (CSPG) core protein. The complex could be reconstituted in vitro using purified serglycin (SG) and proMMP-9 and contained no inter-disulfide bridges. It was suggested that the complex involved both the FnII module and HPX domain of proMMP-9. The aims of the present study were to resolve the interacting regions of the molecules that form the complex and the types of interactions involved...
June 12, 2020: International Journal of Molecular Sciences
#37
JOURNAL ARTICLE
Xiaofang Wang, Hui Xiong, Daning Liang, Zhenzhen Chen, Xiqing Li, Kun Zhang
BACKGROUND: Skin cutaneous melanoma (SKCM) is one of most aggressive type of cancers worldwide. Serglycin (SRGN) is an intracellular proteoglycan that playing an important role in various tumors. However, its effect on immune infiltrates and whether it associates with survival of SKCM and SKCM-metastasis patients has not been explored. METHODS: We evaluated SRGN expression via the databases of Oncomine, Tumor Immune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA)...
May 5, 2020: BMC Cancer
#38
JOURNAL ARTICLE
Zhijie Zhang, Ni Qiu, Jiang Yin, Jianlei Zhang, Hao Liu, Wei Guo, Meijun Liu, Ting Liu, Danyang Chen, Kai Luo, Hongsheng Li, Zhimin He, Jinbao Liu, Guopei Zheng
Background : Chemoresistance is a significant obstacle to the effective treatment of breast cancer (BC), resulting in more aggressive behavior and worse clinical outcome. The molecular mechanisms underlying breast cancer chemoresistance remain unclear. Our microarray analysis had identified the overexpression of a small molecular glycoprotein serglycin (SRGN) in multidrug-resistant BC cells. Here, we aimed to investigate the role of SRGN in chemoresistance of breast cancer and elucidate the underlying mechanisms...
2020: Theranostics
#39
JOURNAL ARTICLE
Ulf Lindahl, Jin-Ping Li
Heparanase was discovered during a study of the heparin proteoglycan (serglycin) in mast cells. Newly synthesized polysaccharide chains, kDa 60-100 x 103 , were rapidly degraded to fragments similar in size to commercially available heparin (averaging 15 x 103 ). Analysis of the degradation products identified reducing-terminal glucuronic acid residues, shown by studies of heparin biosynthesis to be of ßD-configuration in the intact polymer. Heparanase, thus identified as an endo-ßD-glucuronidase, was subsequently identified in a variety of tissues and cells...
2020: Advances in Experimental Medicine and Biology
#40
JOURNAL ARTICLE
H Chen, Y Li, Y Chen, Y Li, E McGowan, Y Lin
No abstract text is available yet for this article.
July 2019: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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