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diagnosis of atopic dermatitis

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https://www.readbyqxmd.com/read/29336013/systematic-review-of-atopic-dermatitis-disease-definition-in-studies-using-routinely-collected-health-data
#1
REVIEW
M P Dizon, A M Yu, R K Singh, J Wan, Mary-Margaret Chren, Carsten Flohr, J Silverberg, D J Margolis, S M Langan, K Abuabara
BACKGROUND: Routinely collected electronic health data (RCD) obtained for administrative and clinical purposes are increasingly used to study atopic dermatitis (AD). Methods for identifying AD patients in RCD differ, and it is unknown how this might affect study results. OBJECTIVES: We sought to evaluate how AD patients have been identified in studies using RCD, to determine whether these methods were validated, and to estimate how the method for identifying AD patients affected variability in prevalence estimates...
January 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29334143/childhood-alopecia-areata-data-from-the-national-alopecia-areata-registry
#2
Iris Wohlmuth-Wieser, Joyce S Osei, David Norris, Vera Price, Maria K Hordinsky, Angela Christiano, Madeleine Duvic
BACKGROUND/OBJECTIVES: Alopecia areata may occur at any age and is the third-most-common dermatosis in children. The objective of this study was to investigate the clinical and epidemiologic features of children and adolescents with alopecia areata based on the data of the National Alopecia Areata registry on children and adolescents. METHODS: Two thousand two hundred eighteen children and adolescents with alopecia areata self-enrolled in the National Alopecia Areata Registry and completed a web-based, self-administered, short-intake screening questionnaire (first tier)...
January 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29319189/epidemiology-of-atopic-dermatitis-in-adults-results-from-an-international-survey
#3
S Barbarot, S Auziere, A Gadkari, G Girolomoni, L Puig, E L Simpson, D J Margolis, M de Bruin-Weller, L Eckert
BACKGROUND: There are gaps in our knowledge of the prevalence of adult atopic dermatitis (AD). OBJECTIVE: To estimate prevalence of AD in adults and by disease severity. METHODS: This international, cross-sectional, web-based survey was performed in the United States, Canada, France, Germany, Italy, Spain, United Kingdom, and Japan. Adult members of online respondent panels were sent a questionnaire for AD identification and severity assessment; demographic quotas ensured population representativeness for each country...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29317281/an-assessment-of-the-use-of-antihistamines-in-the-management-of-atopic-dermatitis
#4
Alice He, Steven R Feldman, Alan B Fleischer
BACKGROUND: Antihistamines are often used to treat pruritus associated with atopic dermatitis (AD) despite lack of evidence for their efficacy. The American Academy of Dermatology does not recommend the general use of antihistamines in the management of AD, although the value of short-term sedating antihistamine use for insomnia secondary to itch is recognized. OBJECTIVE: To assess the use of sedating and non-sedating antihistamines for AD from 2003-2012. METHODS: The National Ambulatory Medical Care Survey (NAMCS) provided data on physician visits from 2003-2012...
January 6, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29305764/the-role-and-diagnosis-of-allergic-contact-dermatitis-in-patients-with-atopic-dermatitis
#5
Joshua L Owen, Paras P Vakharia, Jonathan I Silverberg
Patients with atopic dermatitis (AD) have increased penetration of allergens, immune dysregulation (including shared cytokine pathways), and frequent use of emollients and topical medications, all of which may predispose toward developing allergic contact dermatitis (ACD). Recent systematic reviews have suggested that ACD is a significant clinical problem in both children and adults with AD. While this remains controversial, ACD remains an important comorbidity and potential exacerbant of AD in clinical practice...
January 5, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29247205/prostaglandin-d2-metabolite-in-urine-is-an-index-of-food-allergy
#6
Shingo Maeda, Tatsuro Nakamura, Hiroaki Harada, Yuri Tachibana, Kosuke Aritake, Tatsuo Shimosawa, Yutaka Yatomi, Takahisa Murata
Food allergy is immediate hypersensitive reactions to ingested foods. Since early diagnosis is effective for disease control, development of an objective diagnostic index is required. Using mediator-lipidomics, we found that levels of the urinary prostaglandin D2 (PGD2) metabolite, tetranor-PGDM, reflected the severity of the allergic symptoms and intestinal mast cell hyperplasia in mice. Repeated oral challenges with ovalbumin promoted allergic symptoms in sensitized mice. Particularly, the allergic mice presented with increased numbers of intestinal mast cells, which strongly expressed hematopoietic PGD synthase (H-PGDS)...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29243817/association-between-atopic-dermatitis-and-squamous-cell-carcinoma-a-case-control-study
#7
Janice M Cho, Dawn Marie R Davis, David A Wetter, Adam C Bartley, Jerry D Brewer
BACKGROUND: Conflicting data have been published on whether an association exists between atopic dermatitis (AD) and nonmelanoma skin cancer. This study aimed to determine whether individuals with AD had an increased risk of squamous cell carcinoma (SCC) development. METHODS: We conducted a retrospective, case-control study of patients residing in Olmsted County, Minnesota. Cases were selected from patients seen at Mayo Clinic (Rochester, Minnesota) who had an initial SCC diagnosis (either invasive SCC or SCC in situ) from January 1, 1996, through December 23, 2010...
December 15, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29238123/epidemiology-triggers-and-severity-of-childhood-asthma-in-ilesa-nigeria-implications-for-management-and-control
#8
Bankole Peter Kuti, Kehinde Oluyori Omole
Background: Knowledge about childhood asthma in a locality will assist clinicians to adequately manage the condition. This study set out to report the epidemiology, triggers of exacerbation, comorbid conditions, and severity of childhood asthma at a tertiary health facility in Nigeria and the implication of these, in management and symptoms control. Methods: Over a 15-month study period, children (aged <15 years) with physician-diagnosed asthma were consecutively recruited at the pediatric chest clinic of the hospital...
January 2017: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/29237258/diagnosis-and-management-of-moderate-to-severe-adult-atopic-dermatitis-a-consensus-by-the-italian-society-of-dermatology-and-venereology-sidemast-the-italian-association-of-hospital-dermatologists-adoi-the-italian-society-of-allergy-asthma-and-clinical-immunology
#9
Piergiacomo Calzavara Pinton, Antonio Cristaudo, Caterina Foti, Giorgio W Canonica, Nicola Balato, Antonio Costanzo, Ornella DE Pità, Clara DE Simone, Cataldo Patruno, Giovanni Pellacani, Ketty Peris, Giampiero Girolomoni
Atopic dermatitis (AD) is a chronic immune-mediated inflammatory skin disease, currently recognized as a systemic disease possibly burdened by various comorbidities, including, but not limited to, other allergic conditions. Management guidelines issued by American and European dermatology and allergy scientific societies are available. However, some discrepancies exist in these guidelines, and some aspects of the management process, including diagnosis and severity assessment, as well as therapy duration and switch criteria, are not fully clarified by existing guidelines...
December 14, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29222945/children-with-atopic-dermatitis-may-have-unacknowledged-contact-allergies-contributing-to-their-skin-symptoms
#10
Anne Birgitte Simonsen, Jeanne Duus Johansen, Mette Deleuran, Charlotte Gotthard Mortz, Lone Skov, Mette Sommerlund
BACKGROUND: Whether children with atopic dermatitis have an altered risk of contact allergy than children without atopic dermatitis is frequently debated and studies have been conflicting. Theoretically, the impaired skin barrier in AD facilitates the penetration of potential allergens and several authors have highlighted the risk of underestimating and overlooking contact allergy in children with atopic dermatitis. OBJECTIVE: To determine the prevalence of contact allergy in Danish children with atopic dermatitis and explore the problem of unacknowledged allergies maintaining or aggravating the skin symptoms...
December 9, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29209493/comparison-of-atopy-patch-testing-to-skin-prick-testing-for-diagnosing-mite-induced-atopic-dermatitis-a-systematic-review-and-meta-analysis
#11
REVIEW
Yumei Liu, Jianglong Peng, Ying Zhou, Yubao Cui
Background: Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an important tool in the diagnosis of AD caused by house dust mites. Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD. Methods: A structured search was performed using online databases and bibliographies published as of April 30, 2017...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29205284/magnitude-of-benefit-for-topical-crisaborole-in-the-treatment-of-atopic-dermatitis-in-children-and-adults-does-not-look-promising-a-critical-appraisal
#12
A Ahmed, L Solman, H C Williams
AIM: To assess the efficacy and safety of crisaborole ointment, a phosphodiesterase 4 inhibitor, for the treatment of mild or moderate atopic dermatitis (AD) in two phase III studies (AD-301 and AD-302). DESIGN AND SETTING: Two identically designed multicentre, double-blind randomized controlled trials were conducted in the U.S.A. Participants were randomized 2 : 1 to receive crisaborole or vehicle treatment. In total 47 and 42 investigational centres were identified for AD-301 and AD-302, respectively...
December 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29193127/pregnancy-and-perinatal-conditions-and-atopic-disease-prevalence-in-childhood-and-adulthood
#13
Jessica Gerlich, Nora Benecke, Astrid S Peters-Weist, Sabine Heinrich, Diana Roller, Jon Genuneit, Gudrun Weinmayr, Doris Windstetter, Holger Dressel, U Range, Dennis Nowak, Erika von Mutius, Katja Radon, Christian Vogelberg
BACKGROUND: Previous studies showed controversial results for the influence of pregnancy-related and perinatal factors on subsequent respiratory and atopic diseases in children. The aim of this study was to assess the association between perinatal variables and the prevalence of asthma, bronchial hyperreactivity, flexural eczema, allergic rhinitis, and sensitization in childhood and early adulthood. METHODS: The studied population was first examined in Munich and Dresden in 1995/1996 at age 9-11 yrs...
November 29, 2017: Allergy
https://www.readbyqxmd.com/read/29191053/diagnosis-and-management-of-conjunctivitis-for-the-dermatologist
#14
Melinda Gooderham, Julian McDonald, Kim Papp
Atopic dermatitis is a chronic, sometimes relapsing inflammatory skin condition that presents with pruritus and characteristic skin manifestations. Conjunctivitis is a common ocular comorbidity affecting almost half of patients with the risk increasing with atopic dermatitis severity. Recent targeted biologic therapies that successfully treat atopic skin disease, including dupilumab, which blocks interleukin (IL)-4 and IL-13, as well as agents that block IL-13 alone, have been associated with an increased rate of conjunctivitis in clinical trials...
November 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29176352/new-science-and-treatment-paradigms-for-atopic-dermatitis
#15
James G Dinulos, Alyssa Trickett, Caroline Crudele
PURPOSE OF THE REVIEW: The prevalence of atopic dermatitis is increasing in industrialized countries for unclear reasons. One theory centers on reduced exposure to microbes during infancy and childhood. Alterations in the epidermal permeability barrier, place certain patients at risk for the immunological dysfunction seen in atopic dermatitis. This review examines current research pertaining to the epidermal permeability barrier, the cutaneous microbiome, and the immunology of atopic dermatitis...
February 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29171402/a-short-period-of-breast-feeding-in-infancy-excessive-house-cleaning-absence-of-older-sibling-and-passive-smoking-are-related-to-more-severe-atopic-dermatitis-in-children
#16
Maria Fotopoulou, Maria Iordanidou, Eleni Vasileiou, Grigorios Trypsianis, Athanasios Chatzimichael, Emmanouil Paraskakis
BACKGROUND: Atopic dermatitis (AD) is one of the most common, chronic or chronically relapsing inflammatory skin diseases that affect children. Multiple genetic and environmental factors appear to regulate the pathogenesis of AD. OBJECTIVES: Our aim was to investigate the possible association between family, social, dieting, atopic and environmental factors and the severity of AD evaluated by SCORAD scores in children. MATERIALS & METHODS: The study group included 100 children with AD who attended a paediatric dermatology outpatient clinic with a median age of 18...
November 24, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29168294/association-of-prenatal-folate-status-with-early-childhood-wheeze-and-atopic-dermatitis
#17
Aditi Roy, Mehmet Kocak, Terryl J Hartman, Shanda Vereen, Margaret Adgent, Chandrika Piyathilake, Frances A Tylavsky, Kecia N Carroll
BACKGROUND: Prenatal folic acid supplementation is recommended to prevent birth defects. Some foods are fortified in the U.S.to ensure sufficient intake among reproductive-aged women. However, high prenatal folate exposure may be a risk factor for childhood atopic diseases. We investigated associations between prenatal folate and early childhood wheeze and atopic dermatitis in a U.S. cohort. METHODS: We studied 858 mother-child dyads, enrolled prenatally. Folate was measured in 2(nd) and 3(rd) trimester maternal plasma...
November 23, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29158868/prevalence-of-papular-urticaria-caused-by-flea-bites-and-associated-factors-in-children-1-6%C3%A2-years-of-age-in-bogot%C3%A3-d-c
#18
Evelyne Halpert, Elizabeth Borrero, Milciades Ibañez-Pinilla, Pablo Chaparro, Jorge Molina, Maritza Torres, Elizabeth García
Background: Papular urticaria is a chronic inflammatory disease caused by exposure to arthropod bites. The disease has been reported in children attending medical centers, but the causes as the risk factors associated with the disease have not been established. The objective of this study was to determine the prevalence of papular urticaria caused by flea bite and identify the risk factors in children between 1 to 6 years of age in Bogotá D.C, between March 2009 and June 2011. Methods: A cross-sectional, two-stage, clustered study using random probability sampling and stratified with proportional allocation was carried out in children (1-6 years of age) in educational institutions in Bogotá D...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29133318/examining-the-association-between-maternal-atopy-and-birth-outcomes-using-a-retrospective-cohort-in-the-southeastern-region-of-the-usa
#19
Ayesha Johnson, Thomas Mason, Russell S Kirby, Dennis Ledford, Hamisu M Salihu
OBJECTIVE: To assess birth outcomes in primiparous women with diagnosis of non-asthmatic atopy (NAA). Researchers hypothesised that women with NAA would have reduced the risk of adverse birth outcomes compared with women without NAA. NAA is defined as having allergic rhinitis and/or atopic dermatitis. SETTING: Women were mostly treated in primary care settings in South Carolina, USA. PARTICIPANTS: This is a retrospective cohort study in which participants were identified using a Medicaid database...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29131887/effect-of-an-intervention-to-promote-breastfeeding-on-asthma-lung-function-and-atopic-eczema-at-age-16-years-follow-up-of-the-probit-randomized-trial
#20
Carsten Flohr, A John Henderson, Michael S Kramer, Rita Patel, Jennifer Thompson, Sheryl L Rifas-Shiman, Seungmi Yang, Konstantin Vilchuck, Natalia Bogdanovich, Mikhail Hameza, Richard M Martin, Emily Oken
Importance: Atopic diseases, including asthma and atopic eczema, are the most common chronic conditions of childhood. Objective: To investigate whether an intervention to promote prolonged and exclusive breastfeeding protects against asthma, atopic eczema, and low lung function in adolescence. Design, Setting, and Participants: Follow-up of the Promotion of Breastfeeding Intervention Trial (PROBIT), a cluster randomized trial in 30 Belarusian maternity hospitals and affiliated polyclinics; recruitment of 17 046 healthy term infants took place from June 15, 1996, to December 31, 1997...
January 2, 2018: JAMA Pediatrics
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