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https://www.readbyqxmd.com/read/29327822/efficacy-and-safety-of-long-term-entecavir-therapy-in-a-european-population
#1
Alessandro Collo, Paola Belci, Sharmila Fagoonee, Lucia Loreti, Valeria Gariglio, Ramona Parise, Paola Magistroni, Marilena Durazzo
BACKGROUND: Therapy in chronic hepatitis B (CHB) patients aims at improving their survival by preventing disease progression to cirrhosis and its complications. Entecavir (ETV) is currently a first line therapeutic agent recommended for the treatment of CHB. Our aim was to evaluate the long term outcome of a cohort of CHB patients treated with ETV. METHODS: Thirty-four patients treated with ETV for at least 6 months were included in this study. The virologic response was determined by the dosage of serum HBV-DNA, HBsAg, HBeAg, anti-HBs and anti-HBe antibodies...
January 10, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29323725/serum-igg-antibodies-from-healthy-subjects-up-to-100-years-old-react-to-jc-polyomavirus
#2
Ilaria Bononi, Elisa Mazzoni, Silvia Pietrobon, Marco Manfredini, Elena Trregiani, Marika Rossini, Francesca Lotito, Giovanni Guerra, Paola Rizzo, Fernanda Martini, Mauro Tognon
JC polyomavirus (JCPyV) was identified in 1971 in the brain tissue of a patient (J.C.) affected by the progressive multifocal leukoencephalopathy (PML). JCPyV encodes for the oncoproteins large T antigen (Tag) and small t-antigen (tag). These oncoproteins are responsible of the cell transformation and tumorigenesis in experimental animals. JCPyV is ubiquitous in human populations. After the primary infection, which is usually asymptomatic, JCPyV remains lifelong in the host in a latent phase. Its reactivation may occur in heathy subjects and immunocompromised patients...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29311016/the-development-of-brain-metastases-in-patients-with-renal-cell-carcinoma-epidemiologic-trends-survival-and-clinical-risk-factors-using-a-population-based-cohort
#3
Maxine Sun, Guillermo De Velasco, Priscilla K Brastianos, Ayal A Aizer, Allison Martin, Raphael Moreira, Paul L Nguyen, Quoc-Dien Trinh, Toni K Choueiri
BACKGROUND: The incidence of brain metastases (BM) in patients with renal cell carcinoma (RCC) is hypothesized to have increased in the last 2 decades. OBJECTIVE: To define incidence trends according to patient and clinical characteristics, to identify risk factors, and to describe outcomes of patients with BM for RCC. DESIGN, SETTING, AND PARTICIPANTS: Patients diagnosed with RCC between the years 2010 and 2013 within the Surveillance, Epidemiology, and End Results database...
January 5, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29310810/radiological-features-and-metastatic-patterns-of-thymic-neuroendocrine-tumours
#4
T Araki, L M Sholl, H Hatabu, M Nishino
AIM: To investigate the clinical and image features of thymic neuroendocrine tumours (NETs), and characterise the radiological patterns of recurrence and metastasis on serial imaging studies. MATERIALS AND METHODS: The study included 14 patients (11 males) with a histopathological diagnosis of thymic NETs (one typical carcinoid, eight atypical carcinoid, and five large cell neuroendocrine carcinoma). Preoperative images were assessed for features of primary tumours...
January 5, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29310387/renal-hybrid-oncocytic-chromophobe-tumor-associated-with-multiple-schwannomas-case-report-and-literature-review
#5
Guanghua Liu, Yatong Li, Zhuoran Li, Jingmin Zhou, Zhen Huo, Zhigang Ji
RATIONALE: Renal hybrid oncocytic/chromophobe tumors (HOCTs) are benign tumors containing a mixture of cells with features of chromophobe renal cell carcinoma (CHRCC) and renal oncocytoma (RO). Sporadic HOCT, which means HOCT occurs in patients without Birt-Hogg-Dubé syndrome (BHDS) or renal oncocytosis, is extremely rare. In this article, we would report a new case of a patient with both sporadic HOCT and multiple Schwannomas, which is even rarer than simplex sporadic HOCT. PATIENT CONCERNS: A 48-year-old female was noted with multiple left-kidney masses and a history of multiple Schwannomas...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305201/initial-assessment-of-the-efficacy-of-irreversible-electroporation-ire-in-the-focal-treatment-of-localised-renal-cell-carcinoma-rcc-with-delayed-interval-kidney-tumour-resection-irene-trial-an-ablate-and-resect-pilot-study
#6
Johann J Wendler, Maciej Pech, Frank Fischbach, Julian Jürgens, Björn Friebe, Daniel Baumunk, Markus Porsch, Simon Blaschke, Daniel Schindele, Sandra Siedentopf, Jens Ricke, Martin Schostak, Jens Köllermann, Uwe B Liehr
OBJECTIVES: To assess the efficacy of irreversible electroporation (IRE) ablation of pT1a renal-cell carcinoma (RCC) in the first prospective, monocentric Phase 2a pilot ablate-and-resect study (IRENE trial). It has been postulated that focal IRE can bring about complete ablation of soft-tissue tumours with protection of healthy peritumoral tissue and anatomical structures. METHODS: The first seven study patients, with biopsy-proven pT1a RCC (15-39mm) underwent IRE...
January 2, 2018: Urology
https://www.readbyqxmd.com/read/29302641/cancer-immunotherapy-in-patients-with-new-or-recurrent-malignancies-after-liver-transplantation
#7
REVIEW
Mengqi Liu, Wenzhi Guo, Shuijun Zhang
Cancer immunotherapy, as a new treatment modality, has been shown to be effective, especially in metastatic melanoma and lung cancer. Organ transplantation can be a life-saving procedure for patients with end-stage diseases of lung, heart, kidney and liver. While ironically, as improvements in organ transplantation have extended patients' lives, new or recurrent postsurgical malignancies have become an increasing threat to their long-term survival, especially in patients after liver transplantation due to hepatocellular carcinoma...
December 2017: International Journal of Surgery. Oncology
https://www.readbyqxmd.com/read/29301217/the-role-of-compounds-derived-from-natural-supplement-as-anticancer-agents-in-renal-cell-carcinoma-a-review
#8
REVIEW
Inamul Haque, Arvind Subramanian, Chao H Huang, Andrew K Godwin, Peter J Van Veldhuizen, Snigdha Banerjee, Sushanta K Banerjee
Renal Cell Carcinoma (RCC) is the most prominent kidney cancer derived from renal tubules and accounts for roughly 85% of all malignant kidney cancer. Every year, over 60,000 new cases are registered, and about 14,000 people die from RCC. The incidence of this has been increasing significantly in the U.S. and other countries. An increased understanding of molecular biology and the genomics of RCC has uncovered several signaling pathways involved in the progression of this cancer. Significant advances in the treatment of RCC have been reported from agents approved by the Food and Drug Administration (FDA) that target these pathways...
December 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29301178/epidural-metastasis-in-malignant-thymoma-mimicking-epidural-abscess-case-report-and-literature-review
#9
Ji Yoon Kim, Young Seok Lee, Dong Ho Kang, Min Hye Kim, Jeong Hee Lee, Chul Hee Lee, In Sung Park
Thymoma and thymic carcinoma are rare epithelial tumors that originate from the thymus gland. Extrathoracic metastases occur in the liver, kidney, and bone in 1% to 15% of patients. Although thymoma and thymic carcinoma exhibit highly aggressive biological behavior, spinal metastasis is rare. We describe a 78-year-old man with left wrist and grasp weakness that occurred 7 days before admission. The patient underwent thymoma surgery 7 years ago and was cured. Magnetic resonance images showed a rim-enhanced mass in the C6-7-T1 epidural space...
December 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/29300388/colonoscopy-based-colorectal-cancer-modeling-in-mice-with-crispr-cas9-genome-editing-and-organoid-transplantation
#10
Jatin Roper, Tuomas Tammela, Adam Akkad, Mohammad Almeqdadi, Sebastian B Santos, Tyler Jacks, Ömer H Yilmaz
Most genetically engineered mouse models (GEMMs) of colorectal cancer are limited by tumor formation in the small intestine, a high tumor burden that limits metastasis, and the need to generate and cross mutant mice. Cell line or organoid transplantation models generally produce tumors in ectopic locations-such as the subcutaneous space, kidney capsule, or cecal wall-that do not reflect the native stromal environment of the colon mucosa. Here, we describe detailed protocols to rapidly and efficiently induce site-directed tumors in the distal colon of mice that are based on colonoscopy-guided mucosal injection...
February 2018: Nature Protocols
https://www.readbyqxmd.com/read/29299153/identify-clear-cell-renal-cell-carcinoma-related-genes-by-gene-network
#11
Fangrong Yan, Yue Wang, Chunhui Liu, Huiling Zhao, Liya Zhang, Xiaofan Lu, Chen Chen, Yaoyan Wang, Tao Lu, Fei Wang
Clear cell renal cell carcinoma (ccRCC) is the most prominent type of kidney cancer in adults. The patients within metastatic ccRCC have a poor 5-year survival rate that is less than 10%. It is essential to identify ccRCC -related genes to help with the understanding of molecular mechanism of ccRCC. In this literature, we aim to identify genes related to ccRCC based on a gene network. We collected gene expression level data of ccRCC from the Cancer Genome Atlas (TCGA) for our analysis. We constructed a co-expression gene network as the first step of our study...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29299121/klf15-promotes-the-proliferation-and-metastasis-of-lung-adenocarcinoma-cells-and-has-potential-as-a-cancer-prognostic-marker
#12
Lihua Gao, Hongmei Qiu, Jian Liu, Yuzhen Ma, Jia Feng, Li Qian, Jianguo Zhang, Yifei Liu, Tingting Bian
Lung adenocarcinoma (LADC)is a general form of non-small cell lung cancer that represents a significant threat to public health worldwide. The 5-year-survival rate for LADC is currently below 15%. The transcription factor KLF15, also called kidney-enriched KLF (KKLF), has been proven to play a role in inhibiting proliferation and diversification of carcinoma cells, including those of the endometrium, pancreas and breast, but the involvement of KLF15 in LADC has not previously been studied. In this study, we compared the in vitro expression of KLF15 in human LADC tissues and adjacent normal lung tissues...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29291011/transferrin-receptor-1-upregulation-in-primary-tumor-and-downregulation-in-benign-kidney-is-associated-with-progression-and-mortality-in-renal-cell-carcinoma-patients
#13
Christopher J Greene, Kristopher Attwood, Nitika J Sharma, Kenneth W Gross, Gary J Smith, Bo Xu, Eric C Kauffman
The central dysregulated pathway of clear cell (cc) renal cell carcinoma (RCC), the von Hippel Lindau/hypoxia inducible factor-α axis, is a key regulator of intracellular iron levels, however the role of iron uptake in human RCC tumorigenesis and progression remains unknown. We conducted a thorough, large-scale investigation of the expression and prognostic significance of the primary iron uptake protein, transferrin receptor 1 (TfR1/CD71/TFRC), in RCC patients. TfR1 immunohistochemistry was performed in over 1500 cores from 574 renal cell tumor patient tissues (primary tumors, matched benign kidneys, metastases) and non-neoplastic tissues from 36 different body sites...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289594/cd4-t-cells-promote-renal-cell-carcinoma-proliferation-via-modulating-ybx1
#14
Yong Wang, Yiting Wang, Liang Xu, Xianqi Lu, Donghe Fu, Jing Su, Hua Geng, Guoxuan Qin, Ruibing Chen, Changyi Quan, Yuanjie Niu, Dan Yue
Renal cell carcinoma (RCC) is a common urologic tumor and the third leading cause of death among urological tumors. Recent studies demonstrate that RCC tumors are more heavily infiltrated by lymphocytes than other cancers. However, the exact roles played by CD4+ T cells in RCC proliferation remain unknown. In this study, we cocultured RCC cells with CD4+ T cells. Stable knockdown of YBX1 in RCC cells was constructed. The effects of CD4+ T cells, TGFβ1 and YBX1 on RCC cells were investigated using cell viability assays...
December 28, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29288416/anticancer-activity-of-schiff-base-poloxamer-p85-combination-against-kidney-cancer
#15
Ayşegül Doğan, Selami Demirci, Dilek Telci, Serli Canikyan, Merve Kongur, Bülent Dede, Fikrettin Şahin
PURPOSE: Renal cell carcinoma (RCC) accounts for approximately 80% of the primary renal cancers, and current treatment strategies are not sufficient to provide a certain solution. Since there are not many treatment options, interest in discovery of alternative drugs has increased. METHODS: In the current study, anticancer activity of a novel heterodinuclear Cu(II)-Mn(II) complex (Schiff base-SB) in combination with poly(ethylene oxide) and poly(propylene oxide) block copolymer (pluronic) P85 was tested against RCC...
December 29, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29285364/bilateral-and-multiple-mixed-epithelial-and-stromal-tumors-of-the-kidney-a-case-report
#16
Ryo Minoda, Toshio Takagi, Naohiro Toda, Hiroko Itagaki, Tsunenori Kondo, Hideki Ishida, Yoji Nagashima, Kazunari Tanabe
Mixed epithelial and stromal tumor (MEST) of the kidney is a benign tumor occurring predominantly in older women. Histologically, MEST comprises tubuloglandular and cystic structures in an ovarian-like stroma. Bilateral and multiple cases are rare. We herein present a case of bilateral and multiple MEST in a 43-year-old woman. The patient presented with gross hematuria and was referred to a primary care physician. A computed tomography scan revealed 5 tumors in the right and 2 in the left kidney. Renal cell carcinoma was suspected, and left partial nephrectomy followed by right radical nephrectomy was planned...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29285359/mucinous-tubular-and-spindle-cell-carcinoma-with-a-high-nuclear-grade-and-micropapillary-pattern-a-case-report
#17
Toru Sakatani, Yoshinaga Okumura, Naoto Kuroda, Toshihiro Magaribuchi, Yorika Nakano, Toshiaki Shirahase, Jun Watanabe, Yoji Taki, Mitsuhiko Okigaki, Susumu Ikehara, Yasushi Adachi
Mucinous tubular and spindle cell carcinoma (MTSCC) is rare in renal cell carcinoma (RCC) and usually demonstrates a low nuclear grade and a better prognosis compared with other RCCs. The authors present a case report of MTSCC containing an area of Fuhrman nuclear grade 3, in addition to an area with a micropapillary pattern. An 82-year-old man consulted a hospital due to macrohematuria, and a tumor in the right kidney was detected. The tumor was resected and histologically examined. The tumor consisted of various growth patterns: Elongated tubular structure, a papillary structure containing a micropapillary pattern and solid pattern with spindle cells...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29283437/analytic-survey-of-57-cases-of-oral-metastases
#18
Yingci Liu, Richard J Vargo, Elizabeth A Bilodeau
BACKGROUND: Oral lesions have been reported among the first signs of an undiagnosed metastatic disease. Accurate diagnosis of an occult metastasis remains critical in determining the treatment course. Previous studies regarding oral metastatic tumors present varied data regarding the most frequent metastases to the oral cavity. These discrepancies echo the changes in incidence rates for certain malignancies over time and demonstrate the need for periodic updates in oral metastasis studies...
December 28, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29282485/identification-of-a-novel-lncrna-induced-by-the-nephrotoxin-ochratoxin-a-and-expressed-in-human-renal-tumor-tissue
#19
Mirjana Polovic, Sandro Dittmar, Isabell Hennemeier, Hans-Ulrich Humpf, Barbara Seliger, Paolo Fornara, Gerit Theil, Patrick Azinovic, Alexander Nolze, Marcel Köhn, Gerald Schwerdt, Michael Gekle
Long non-coding RNAs represent a fraction of the transcriptome that is being increasingly recognized. For most of them no function has been allocated so far. Here, we describe the nature and function of a novel non-protein-coding transcript, named WISP1-AS1, discovered in human renal proximal tubule cells exposed to the carcinogenic nephrotoxin ochratoxin A. WISP1-AS1 overlaps parts of the fourth intron and fifth exon of the Wnt1-inducible signaling pathway protein 1 (WISP1) gene. The transcript is 2922 nucleotides long, transcribed in antisense direction and predominantly localized in the nucleus...
December 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29282443/first-ever-use-of-proton-stereotactic-body-radiation-therapy-delivered-with-curative-intent-to-bilateral-synchronous-primary-renal-cell-carcinomas
#20
Melissa A Frick, Arpit M Chhabra, Liyong Lin, Charles B Simone Ii
Limited therapeutic options exist for inoperable bilateral kidney tumors. We report the first ever use of proton therapy to treat primary renal cell carcinoma (RCC) and the first report of proton stereotactic body radiation therapy (SBRT) for RCC in an inoperable patient with synchronous RCCs treated with proton SBRT. The patient is a 47-year-old 450-pound female with multiple medical comorbidities, including Stage 3 chronic kidney disease (CKD), who was found to have bilateral renal masses during work-up for cellulitis and sepsis...
October 24, 2017: Curēus
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