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Non pharmacologic pain

Sigrid Dierickx, Joachim Cohen, Robert Vander Stichele, Luc Deliens, Kenneth Chambaere
CONTEXT: - According to guideline recommendations, barbiturates and neuromuscular relaxants are the recommended drugs for euthanasia. OBJECTIVES: - To describe changes over time in drugs used to perform euthanasia and differences in case characteristics according to the drugs used. METHODS: - Repeated population-based mortality follow-back study among physicians attending a large representative sample of deaths in 1998, 2007 and 2013 in Flanders, Belgium...
July 12, 2018: Journal of Pain and Symptom Management
David Rodriguez Sanz, Francisco Unda Solano, Daniel López López, Irene Sanz Corbalan, Carlos Romero Morales, Cesar Calvo Lobo
Introduction: Oral ibuprofen (OI) and median nerve neural mobilization (MNNM) are first line treatments for patients who suffer cervicobrachial pain (CP). OI may produce side effects which are not tolerated by all subjects who suffer CP, whereas MNNM has no known side effects. Therefore, the aim of this study was to assess the effectiveness of both treatments (OI vs. MNNM) in CP. Material and methods: This investigation was a blinded parallel randomized clinical trial (NCT02593721)...
June 2018: Archives of Medical Science: AMS
Marion K Slack, Ramon Chavez, Daniel Trinh, Daniel Vergel de Dios, Jeannie Lee
BACKGROUND AND AIMS: Acute pain is differentiated from chronic pain by its sudden onset and short duration; in contrast, chronic pain is characterized by a duration of at least several months, typically considered longer than normal healing time. Despite differences in definition, there is little information on how types of self-management strategies or outcomes differ when pain is chronic rather than acute. Additionally, age and gender are thought to be related to types of strategies used and outcomes...
July 11, 2018: Scandinavian Journal of Pain
Melissa L Mehalick, Amanda C Glueck
In this review, we discuss the comorbidity of traumatic brain injury (TBI) and pain among civilians and military members, the common causes of pain resulting from TBI, and offer insight about the therapeutic management of TBI symptoms and pain. Traumatic brain injury (TBI) is a debilitating health problem and one of the most common post-TBI symptoms is pain, which can contribute to psychological issues such as Post-traumatic stress disorder (PTSD) and depression. Headache pain appears to be the most common type of pain that results from TBI, yet pain can also be more widespread...
July 11, 2018: Brain Injury: [BI]
R Vellucci, R Terenzi, J A Kanis, H G Kress, R D Mediati, J-Y Reginster, R Rizzoli, M L Brandi
Osteoporosis, a disorder that affects millions of people worldwide, is characterized by decreased bone mass and microstructural alterations giving rise to an increased risk of fractures. Osteoporotic fractures can cause acute and chronic nociceptive and neuropathic pain that mainly affects elderly patients with multiple comorbidities and commonly on different drug regimens. Central sensitization seems to play a pivotal role in developing and maintaining chronicity of post-fracture pain in osteoporosis. Antiosteoporosis drugs are able to partially control pain, but additional analgesics are always necessary for pain due to bone fractures...
July 10, 2018: Osteoporosis International
Anwar Baban, Marco Castori
Joint hypermobility (JH) is the hallmark of many hereditary soft connective tissue disorders, including Ehlers-Danlos syndromes and related disorders, disorders of the TGFβ-pathway, lateral meningocele syndrome, arterial tortuosity syndrome and cutis laxa syndromes. Contemporary practice separates individuals with isolated, non-syndromic JH, from patients with Mendelian syndromes and those with hypermobility spectrum disorders. The latter is a new nosologic entity grouping together individuals with JH and related musculoskeletal manifestations, but lacking inclusion criteria for well-defined and/or single-gene disorders...
July 6, 2018: Expert Review of Clinical Pharmacology
B Meyer, A Keller, B Müller, H-G Wöhlbier, P Kropp
Progressive muscle relaxation (PMR) after Jacobson has been used for migraine prophylaxis since the early 1970s. Migraine patients are assumed to have an enhanced autonomic arousal which can be counterbalanced by systematic relaxation. Relaxation techniques are thought to reduce the activation level, to alter cortical pain processing and to enhance activation in pain-reducing cortical structures in the periaqueductal grey matter. Meta-analyses could show PMR to be just as efficacious as pharmacological treatment options...
July 4, 2018: Der Schmerz
Stefan Wöhrl
Background: Adverse drug reactions (ADR) to analgesics (i.e., non-steroidal anti-inflammatory drug hypersensitivity, NSAID-HS) are one of the most common ADR, affecting approximately 1.6% of all patients. Despite the fact that they are common, they still pose a diagnostic challenge. Methods: This article is an overview of selected scientific articles and is based on research in PubMed, specialist databases, and guidelines. Results: Approximately 80% of side effects are pharmacologically predictable and are classified as type A reactions, such as abdominal pain and bleeding events...
2018: Allergo Journal International
Lívia Maria Nunes Campelo, Nayara Fernandes Oliveira, Juliana Macêdo Magalhães, Alcineide Mendes de Sousa Julião, Fernanda Cláudia Miranda Amorim, Magda Coeli Vitorino Sales Coelho
OBJECTIVE: To describe how nurses identify the pain in children with sickle cell disease (SCD) and to list the strategies used by them in the evaluation and control of pain. METHOD: This is a qualitative, descriptive and exploratory research, performed through semi-structured interviews with 13 nurses. The interviews were transcribed and after this process the qualitative data were organized according to thematic analysis. RESULTS: This study showed that the nurses can identify pain in children with SCD from the signals they emit, such as: constant crying, restlessness, facial expressions and verbal reports...
2018: Revista Brasileira de Enfermagem
Juliana Vieira Figueiredo, Ana Virgínia de Melo Fialho, Glícia Mesquita Martiniano Mendonça, Dafne Paiva Rodrigues, Lúcia de Fátima da Silva
OBJECTIVE: to analyze the contribution of clinical nursing care to the mother who has recently given birth with immediate postpartum pain based on the Kolcaba's Theory of Comfort. METHOD: qualitative study by the research-care method. Three nurses, who provided care for women in the immediate puerperium as caregiver-researchers and 30 postpartum women, were admitted to a public maternity hospital. A semi-structured interview was used for data collection, from which the thematic analysis of the content was carried out...
2018: Revista Brasileira de Enfermagem
Amanda Reis, Caitlyn Luecke, Thomas Keefe Davis, Aadil Kakajiwala
Pain is a common problem in children with chronic kidney disease (CKD); however, limited data exist regarding its management. Although most pain is managed pharmacologically, in some instances non-pharmacologic management can aid in safely ameliorating discomfort. Because of the accumulation of toxic metabolites, many common pain medications have adverse effects on kidney function or altered pharmacokinetics in the setting of CKD. Decreased clearance impacts safe dosing of analgesics. The pain management of patients on renal replacement therapy requires an understanding of drug clearance due to the different modalities of dialysis...
May 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Anne Perroteau, Marie-Christine Nanquette, Alexandra Rousseau, Sylvain Renolleau, Laurence Bérard, Delphine Mitanchez, Judith Leblanc
BACKGROUND: Reducing acute pain in premature infants during neonatal care improves their neurophysiological development. The use of pharmacological and non-pharmacological analgesia, such as sucrose, is limited per day, particularly for very preterm infants. Thus, the usual practice of non-nutritive sucking is often used alone. Facilitated tucking could be an additional strategy to non-nutritive sucking for reducing pain. To the best of our knowledge, no randomized trial has compared the combination of facilitated tucking and non-nutritive sucking to non-nutritive sucking alone...
June 15, 2018: International Journal of Nursing Studies
Robert Jay Rowen
INTRODUCTION: This case uniquely reports a connection between endodontically infected teeth and systemic disease, and additionally presents ozone therapy as a unique therapy and immune system modulator. It is the world's first such reported case and the treatment holds invaluable lessons in assessing the "unknown" causes of autoimmunity and inflammation. Additionally, it presents ozone therapy as a most needed unique, non-toxic and powerful anti-infective agent, anti-inflammatory and immune modulator...
June 30, 2018: Auto- Immunity Highlights
E Scala Emmanuelle, I Decosterd, M Faouzi, B Burnand, P-Y Rodondi
Given the limited alleviation of chronic pain with pharmacological treatments, various non-pharmacological and self-care approaches are often proposed, that require patients' motivation OBJECTIVE: Evaluation of the level of readiness (LOR) to practice different types of active self-care among chronic pain patients METHOD: A quantitative cross-sectional survey was conducted among all chronic pain patients seeking care at the Pain Center of an academic hospital from June 2013 to March 2015. Sociodemographic data, pain characteristics, treatments and the LOR to practice active self-care were investigated RESULTS: Among the 1524 eligible patients, 639 (41...
June 29, 2018: European Journal of Pain: EJP
Hendriekje Eggink, Stanislaw Szlufik, Maraike A Coenen, Martje E van Egmond, Elena Moro, Marina A J Tijssen
INTRODUCTION: Deep brain stimulation (DBS) has emerged as an effective treatment in medically intractable dystonia, with the globus pallidus internus (GPi) being most frequently targeted. Non-motor symptoms, including pain and psychiatric, cognitive and sleep disturbances, are increasingly recognized as important determinants of disease burden in dystonia patients. We reviewed non-motor outcomes of DBS in dystonia, focusing on GPi-DBS. METHODS: A systematic literature search of Pubmed and Embase was performed according to the PRISMA guidelines...
June 20, 2018: Parkinsonism & related Disorders
Mario Alberto Isiordia-Espinoza, Ronell Eduardo Bologna-Molina, Ycenna Ailed Hernández-Miramontes, Juan Ramón Zapata-Morales, Angel Jobsabad Alonso-Castro, Flavio Martínez-Morales, Sergio Sánchez-Enriquez, Nicolás Addiel Serafín-Higuera, Guillermo Pérez-Cortez, Lorenzo Franco-de la Torre
AIMS: The purpose of this meta-analysis was to evaluate the clinical efficacy of non-steroidal anti-inflammatory drugs and dexamethasone on the trismus, postsurgical pain, facial swelling, as well as the analgesic consumption after third molar surgery. MATERIAL AND METHODS: The reports were identified in the most important medical databases. Those studies that met the requirements were fully assessed according to the inclusion and exclusion criteria. The quality of each report was evaluated with the Oxford Quality Scale and using the Cochrane Collaboration's risk of bias tool...
June 26, 2018: Drug Research
Elena Manguzzi, Laura Wainstein, Jules Desmeules, Barbara Broers
Treatment of acute nociceptive pain in patients with opioid substitution therapy (OST) is an actual topic. The clinical features of this population, as pain sensibility, and the pharmacological features of OST, require an individualized care which must be adjusted to the patient's pain and the OST used. This article offers a summary of the main possible pharmacological strategies by highlighting the features of pain in these patients and removing the barriers to an effective management. Generally, the OST is kept and a multimodal analgesia is added according to the intensity of the pain...
June 20, 2018: Revue Médicale Suisse
Tiaw-Kee Lim, Yan Ma, Frederic Berger, Gerhard Litscher
Within the last 10 years, the percentage of low back pain (LBP) prevalence increased by 18%. The management and high cost of LBP put a tremendous burden on the healthcare system. Many risk factors have been identified, such as lifestyle, trauma, degeneration, postural impairment, and occupational related factors; however, as high as 95% of the cases of LBP are non-specific. Currently, LBP is treated pharmacologically. Approximately 25 to 30% of the patients develop serious side effects, such as drowsiness and drug addiction...
June 25, 2018: Medicines (Basel, Switzerland)
Stephen J Chester, Zephanie Tyack, Alexandra De Young, Belinda Kipping, Bronwyn Griffin, Kellie Stockton, Robert S Ware, Xi Zhang, Roy M Kimble
No randomized controlled trial (RCT) has investigated the efficacy of hypnosis for reducing pain and improving healing in children with burns. This RCT aimed to investigate whether hypnosis decreases pain, anxiety and stress and accelerates wound-healing in children undergoing burn wound procedures. Children (4 to 16 years) with acute burns presenting for their first dressing change were randomly assigned to a Hypnosis Group who received hypnosis plus standard care or a Standard Care Group who received standard pharmacological and non-pharmacological intervention...
June 21, 2018: Pain
Jie Tao, Feng Jiang, Cheng Liu, Zhirui Liu, Yudan Zhu, Jian Xu, Yiqin Ge, Kan Xu, Peihao Yin
Chan-su (toad venom) has been used as an analgesic agent in China from ancient to modern times. Bufalin, a non-peptide toxin extracted from toad venom, is considered as one of the analgesic components. The molecular mechanism underlying the anti-nociceptive effects of bufalin remains unclear so far. In this study, we investigated the pharmacological effects of bufalin on pain-related ion channels as well as animal models through patch clamping, calcium imaging and animal behavior observation. Using the whole-cell recording, bufalin caused remarkable suppressive effect on the peak currents of Nav channels (voltage gated sodium channels, VGSCs) of dorsal root ganglion neuroblastomas (ND7-23 cell) in a dose-dependent manner...
June 21, 2018: Molecular Biology Reports
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