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https://www.readbyqxmd.com/read/28435236/activities-specific-balance-confidence-scale-for-predicting-future-falls-in-indian-older-adults
#1
Jamal Ali Moiz, Vishal Bansal, Majumi M Noohu, Shailendra Nath Gaur, Mohammad Ejaz Hussain, Shahnawaz Anwer, Ahmad Alghadir
BACKGROUND: Activities-specific balance confidence (ABC) scale is a subjective measure of confidence in performing various ambulatory activities without falling or experiencing a sense of unsteadiness. OBJECTIVE: This study aimed to examine the ability of the Hindi version of the ABC scale (ABC-H scale) to discriminate between fallers and non-fallers and to examine its predictive validity for prospective falls. DESIGN: This was a prospective cohort study...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28401876/dolutegravir-abacavir-lamivudine-versus-current-art-in-virally-suppressed-patients-striiving-a-48-week-randomized-non-inferiority-open-label-phase-iiib-study
#2
Benoît Trottier, Jordan E Lake, Ken Logue, Cynthia Brinson, Lizette Santiago, Clare Brennan, Justin A Koteff, Brian Wynne, Judy Hopking, Catherine Granier, Michael Aboud
BACKGROUND: Simplified dosing regimens are important for patients who face challenges in adhering to HIV-1 therapy. We investigated the safety and virologic efficacy of switching to once-daily abacavir/dolutegravir/lamivudine (ABC/DTG/3TC). METHODS: The STRIIVING study was a randomized, open-label, phase IIIb study in adults with HIV-1 RNA <50 copies/mL on antiretroviral therapy (ART) at enrolment (ClinicalTrials.gov identifier, NCT02105987). Subjects were randomly assigned to switch to ABC/DTG/3TC once daily for 48 weeks (early-switch group) or continue current ART for 24 weeks and then switch to ABC/DTG/3TC (late-switch group)...
April 12, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28396041/association-of-holter-derived-heart-rate-variability-parameters-with-the-development-of-congestive-heart-failure-in-the-cardiovascular-health-study
#3
Vaiibhav N Patel, Brian R Pierce, Rohan K Bodapati, David L Brown, Diane G Ives, Phyllis K Stein
OBJECTIVES: This study sought to determine whether Holter-based parameters of heart rate variability (HRV) are independently associated with incident heart failure among older adults in the CHS (Cardiovascular Health Study) as evidenced by an improvement in the predictive power of the Health Aging and Body Composition Heart Failure (Health ABC) score. BACKGROUND: Abnormal HRV, a marker of autonomic dysfunction, has been associated with multiple adverse cardiovascular outcomes but not the development of congestive heart failure (CHF)...
March 30, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28392324/the-reliability-and-validity-of-the-timed-up-and-go-motor-test-for-people-with-chronic-stroke
#4
Peggy P K Chan, Joyce I F Si Tou, Mimi M Y Tse, Shamay S M Ng
OBJECTIVES: To examine: (1) the intra-rater, inter-rater and test-retest reliabilities of the timed up and go (motor) test (TUGmotor) in terms of the number of steps taken and completion time with a chronic stroke population; (2) the relationship between stroke-specific impairments and the number of steps taken in the test and the completion time; (3) the minimal detectable change in TUGmotor times; and (4) the cut-off time which best discriminates the performance of people with stroke from that of healthy older adults...
April 6, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28381513/outcome-of-intracerebral-hemorrhage-associated-with-different-oral-anticoagulants
#5
Duncan Wilson, David J Seiffge, Christopher Traenka, Ghazala Basir, Jan C Purrucker, Timolaos Rizos, Oluwaseun A Sobowale, Hanne Sallinen, Shin-Joe Yeh, Teddy Y Wu, Marc Ferrigno, Rik Houben, Floris H B M Schreuder, Luke A Perry, Jun Tanaka, Marion Boulanger, Rustam Al-Shahi Salman, Hans R Jäger, Gareth Ambler, Clare Shakeshaft, Yusuke Yakushiji, Philip M C Choi, Julie Staals, Charlotte Cordonnier, Jiann-Shing Jeng, Roland Veltkamp, Dar Dowlatshahi, Stefan T Engelter, Adrian R Parry-Jones, Atte Meretoja, David J Werring
OBJECTIVE: In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non-vitamin K antagonist oral anticoagulation-related ICH (NOAC-ICH) and vitamin K antagonist-associated ICH (VKA-ICH). METHODS: We compared all-cause mortality within 90 days for NOAC-ICH and VKA-ICH using a Cox proportional hazards model adjusted for age; sex; baseline Glasgow Coma Scale score, ICH location, and log volume; intraventricular hemorrhage volume; and intracranial surgery...
April 5, 2017: Neurology
https://www.readbyqxmd.com/read/28380163/aging-as-a-predictor-of-nursing-workload-in-intensive-care-unit-results-from-a-brazilian-sample
#6
Renata Eloah de Lucena Ferretti-Rebustini, Lilia de Souza Nogueira, Rita de Cassia Gengo E Silva, Vanessa de Brito Poveda, Selma Pinheiro Machado, Elaine Machado de Oliveira, Rafaela Andolhe, Katia Grillo Padilha
OBJECTIVE: Verify if aging is an independent predictor of NW in ICU, according to age groups, and its predictive value as a determinant of NW in ICU. METHODS: Study was conducted from 2012 to 2016. A convenience sample composed by patients (age ≥ 18) admitted to nine ICU belonging to a Brazilian hospital, was analyzed. Age was assumed as an independent variable and NW (measured by the Nursing Activities Score - NAS) as dependent. Linear regression model and ROC curve were used for the analysis...
April 3, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28374334/long-term-outcome-of-patients-with-liver-cirrhosis-admitted-to-a-general-intensive-care-unit
#7
Alex Warren, Charlotte R Soulsby, Alex Puxty, Joseph Campbell, Martin Shaw, Tara Quasim, John Kinsella, Joanne McPeake
OBJECTIVES: The prevalence of liver cirrhosis is increasing, and many patients have acute conditions requiring consideration of intensive care. This study aims to: (a) report the outcome at 12 months of patients with cirrhosis admitted to ICU, (b) identify factors predictive of long-term mortality and (c) evaluate the ability of scoring systems to predict long-term outcome. DESIGN: Observational cohort study. SETTING: General adult critical care unit in a UK teaching hospital...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28336309/usefulness-of-the-ellipro-epitope-predictor-program-in-defining-the-repertoire-of-hla-abc-eplets
#8
Rene J Duquesnoy, Marilyn Marrari
HLA matching at the epitope level offers new opportunities to identify suitable donors for transplant patients. The International HLA Epitope Registry (www.Epregistry.com.br) describes for the various HLA loci, repertoires of eplets including those that correspond to epitopes experimentally verified with specific antibodies. There are also many eplets which have remained as theoretical entities because no informative antibodies have been found. Which of them have immunogenic potential or conversely, might be considered as non-epitopes that cannot elicit specific antibody responses? This question is important for the application of epitope-based HLA matching in clinical transplantation...
March 20, 2017: Human Immunology
https://www.readbyqxmd.com/read/28334053/new-insights-of-altered-lipid-profile-in-fragile-x-syndrome
#9
Artuela Çaku, Nabil G Seidah, Audrey Lortie, Nancy Gagné, Patrice Perron, Jean Dubé, Francois Corbin
BACKGROUND: Fragile X Syndrome (FXS) is the main genetic cause of autism and intellectual deficiency resulting the absence of the Fragile X Mental Retardation Protein (FMRP). Clinical picture is characterized by cognitive impairment associated with a broad spectrum of psychiatric comorbidities including autism spectrum disorders and attention-deficit/hyperactivity disorders. Some of these disorders have been associated with lipid abnormalities and lower cholesterol levels. Since lipids are important for neuronal development, we aim to investigate the lipid profile of French Canadian-FXS individuals and to identify the altered components of cholesterol metabolism as well as their association with clinical profile...
2017: PloS One
https://www.readbyqxmd.com/read/28317138/impact-of-providing-psychiatry-specialty-pharmacist-intervention-on-reducing-drug-related-problems-among-children-with-autism-spectrum-disorder-related-to-disruptive-behavioural-symptoms-a-prospective-randomized-open-label-study
#10
R Wongpakaran, T Suansanae, T Tan-Khum, C Kraivichian, R Ongarjsakulman, C Suthisisang
WHAT IS KNOWN AND OBJECTIVES: Psychopharmacologic therapy has so far focused on ameliorating disruptive behaviours to improve patient's function and quality of life. Due to the complicated neurobiological aetiology of autism spectrum disorder (ASD), a traditional pharmacist intervention may be insufficient to initiate the optimal care for this vulnerable population. We evaluate the impact of providing specialty psychiatry (PS) pharmacist intervention in identifying and resolving drug-related problems (DRPs) among children with ASD associated with disruptive behaviours...
March 20, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28268190/the-short-version-of-the-activities-specific-balance-confidence-scale-for-older-adults-with-diabetes-convergent-discriminant-and-concurrent-validity-a-pilot-study
#11
Patricia Hewston, Nandini Deshpande
OBJECTIVES: The short version of the Activities-Specific Balance Confidence Scale (ABC-6) is advantageous in busy clinical or research settings because it can be administered in less time than the original 16-item Activities-Specific Balance Confidence Scale (ABC-16). This pilot study examined the convergent, discriminant and concurrent validity of the ABC-6 in older adults with diabetes mellitus with and without diagnosed diabetic peripheral neuropathy (DPN). METHODS: Thirty older adults (aged ≥65) were age- and sex-matched in 3 groups: 10 with diabetes (DM group), 10 with diagnosed DPN (DPN group) and 10 without diabetes (no-DM group)...
March 3, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28248435/trpm4-expression-is-associated-with-activated-b-cell-subtype-and-poor-survival-in-diffuse-large-b-cell-lymphoma
#12
Suet Kee Loo, Ewe Seng Ch'ng, Md Salzihan Md Salleh, Alison H Banham, Lars M Pedersen, Michael B Møller, Tina M Green, Kah Keng Wong
AIMS: Transient receptor potential channel melastatin 4 (TRPM4) is an ion channel that regulates influx of calcium cations (Ca(2+) ). Recent studies suggest that TRPM4 is an oncoprotein and its upregulated transcript level has been reported in diffuse large B-cell lymphoma (DLBCL). We aim to investigate TRPM4 protein expression pattern in non-malignant tissues and DLBCL cases, and its association with clinico-demographical parameters and survival in DLBCL. METHODS AND RESULTS: Analysis of publicly-available DLBCL microarray datasets showed that TRPM4 transcripts were upregulated in DLBCL compared to normal germinal centre B (GCB) cells, were more highly expressed in the activated B-cell-like DLBCL (ABC-DLBCL) subtype, and higher TRPM4 transcripts conferred worse overall survival (OS) in R-CHOP-treated DLBCL cases (P<0...
March 1, 2017: Histopathology
https://www.readbyqxmd.com/read/28198046/muscle-fatigability-and-depressive-symptoms-in-later-life
#13
Patrick J Brown, Dala Badreddine, Steven P Roose, Bret Rutherford, Hilsa N Ayonayon, Kristine Yaffe, Eleanor M Simonsick, Bret Goodpaster
OBJECTIVE: Fatigability is the degree to which performance decreases during a specific activity of a given intensity and duration. Depression is known to heighten subjective fatigue, but whether its association with physical fatigability is unknown. Further, whether fatigability is a precursor or risk factor for the development of subsequent depressive symptoms is also unclear. METHODS: Data are from the Health Aging and Body Composition Study with fatigability assessed using isokinetic dynamometry of the knee extensors at year 3, and depressive symptoms ascertained longitudinally using the Center for Epidemiologic Studies Depression (CES-D) scale...
February 15, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28185287/tumor-size-and-invasiveness-matters-for-partial-nephrectomy-external-validation-and-modification-of-the-arterial-based-complexity-score
#14
Maximilian C Kriegmair, Svetlana Hetjens, Philipp Mandel, Jula Wadle, Johannes Budjan, Maurice S Michel, Daniel Pfalzgraf, Nina Wagener
BACKGROUND: Outcome of partial nephrectomy (PN) depends on anatomic features of the renal tumor, which can be assessed by nephrometry scores. The aim was to externally validate and refine the Arterial Based Complexity (ABC) score and to compare it to established systems. METHODS: Tumors of 300 patients undergoing PN were categorized according to the ABC, RENAL, and PADUA score. Size and tumor invasiveness were combined to form the ABCD score. Correlation analysis and multivariate logistic regression was performed to validate and compare the respective scores as predictors of surgical outcome...
February 10, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28184165/visual-spatial-training-efficacy-in-children-affected-by-migraine-without-aura-a-multicenter-study
#15
Francesco Precenzano, Maria Ruberto, Lucia Parisi, Margherita Salerno, Agata Maltese, Beatrice Gallai, Rosa Marotta, Serena Marianna Lavano, Francesco Lavano, Michele Roccella
Routinely in the clinical practice, children affected by migraine without aura (MwA) tend to exhibit severe and persistent difficulties within cognitive processes such as attention, memory, and visual-motor integration (VMI) skills. The aim of this study was to assess the visual-spatial and visual-motor abilities among a sample of children with MwA and the effects of a specific computerized training. The study population was composed of 84 patients affected by MwA (39 girls and 45 boys; mean age: 8.91±2.46 years), and they were randomly divided into two groups (group A and group B) comparable for age (P=0...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28182895/validity-test-retest-reliability-sensitivity-to-change-and-feasibility-of-motor-cognitive-dual-task-assessments-in-patients-with-dementia
#16
Nele C Lemke, Stefanie Wiloth, Christian Werner, Klaus Hauer
OBJECTIVE: To investigate validity, test-retest reliability, sensitivity to change, and feasibility of dual task (DT) assessments in patients with dementia. DESIGN: Validation study. SETTING: Post ward-rehabilitation. PARTICIPANTS: Geriatric patients (n=105) with dementia (age 82.7±5.9, MMSE score 21.9). MAIN OUTCOME MEASURES: Psychometric quality of DT performance of different DT-tests. Analyses were performed for motor and cognitive performance, and relative DT costs (DTCs)...
May 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28178773/postural-control-of-individuals-with-chronic-stroke-compared-to-healthy-participants-tug-frt-and-center-of-pressure-movement
#17
Sigal Portnoy, Shlomit Reif, Tom Mendelboim, Debbie Rand
BACKGROUND: Balance impairments are common following stroke, and may lead to loss of independent functional mobility and falls. Previous studies strived to come up with precise measures of postural control, which will provide a better prognostic power for the health status and safety of the individual. To date, the degree of difference in postural control measures between individuals with chronic stroke and healthy participants is not reported. Also there are no reported correlations between these measures and the Timed-Up-and-Go (TUG) and the Functional Reach Test (FRT)...
February 8, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28166747/investigating-the-validation-of-the-chinese-mandarin-version-of-the-social-responsiveness-scale-in-a-mainland-china-child-population
#18
Chao-Qun Cen, Ya-Yong Liang, Qiu-Ru Chen, Kai-Yun Chen, Hong-Zhu Deng, Bi-Yuan Chen, Xiao-Bing Zou
BACKGROUND: Researchers from several different countries have found the Social Responsiveness Scale (SRS) to have good psychometric properties. However, to our knowledge, no studies on this subject have been reported in Mainland China. In this study, we investigated the psychometric properties of the Chinese Mandarin version of the SRS when used in Mainland China. METHODS: The reliability and validity of the parent-report SRS in a sample of 749 children of 4- to 14-year-olds: 411 typically developing and 338 clinical participants (202 with autism spectrum disorder (ASD)) were examined...
February 6, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28152611/effects-of-the-abc-intervention-on-foster-children-s-receptive-vocabulary
#19
Kristin Bernard, Amy Hyoeun Lee, Mary Dozier
Children with histories of maltreatment and disruptions in care are at elevated risk for impairments in early language development, which contribute to difficulties in other developmental domains across childhood. Given research demonstrating associations between parent responsiveness and children's early language development, we examined whether a parenting intervention administered in infancy improved preschool receptive language skills in children involved with the child welfare system. Attachment and Biobehavioral Catch-up (ABC) is a 10-session intervention that aims to enhance parent-child interactions...
January 1, 2017: Child Maltreatment
https://www.readbyqxmd.com/read/28133505/oxidative-stress-as-a-physiological-pain-response-in-full-term-newborns
#20
S Perrone, C V Bellieni, S Negro, M Longini, A Santacroce, M L Tataranno, F Bazzini, E Belvisi, A Picardi, F Proietti, L Iantorno, G Buonocore
This research paper aims to investigate if oxidative stress biomarkers increase after a painful procedure in term newborns and if nonpharmacological approaches, or sex, influence pain degree, and the subsequent OS. 83 healthy term newborns were enrolled to receive 10% oral glucose or sensorial saturation (SS) for analgesia during heel prick (HP). The ABC scale was used to score the pain. Advanced oxidation protein products (AOPP) and total hydroperoxides (TH) as biomarkers of OS were measured at the beginning (early-sample) and at the end (late-sample) of HP...
2017: Oxidative Medicine and Cellular Longevity
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