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https://www.readbyqxmd.com/read/27925044/application-of-prognostic-score-ipset-thrombosis-in-patients-with-essential-thrombocythemia-of-a-brazilian-public-service
#1
Luana Magalhães Navarro, Damila Cristina Trufelli, Debora Rodrigues Bonito, Auro Del Giglio, Patricia Weinschenker Bollmann
Introduction: In patients with essential thrombocythemia (ET), the vascular complications contribute to morbidity and mortality. To better predict the occurrence of thrombotic events, an International Prognostic Score for Thrombosis in Essential Thrombocythemia (IPSET-thrombosis) has recently been proposed. We present the application of this score and compare its results with the usual classification system. Method: We retrospectively evaluated the characteristics and risk factors for thrombosis of 46 patients with a diagnosis of ET seen in the last 6 years at Faculdade de Medicina do ABC (FMABC)...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27898155/balance-confidence-and-activity-of-community-dwelling-patients-with-transtibial-amputation
#2
Alena Mandel, Kailan Paul, Ruby Paner, Michael Devlin, Steve Dilkas, Tim Pauley
The purpose of this study was to examine the relationship between balance confidence and community-based physical activity. Twenty-two community-dwelling patients with right or left unilateral transtibial amputation who reported no falls in the past 6 mo completed the Activities-Specific Balance Confidence Scale (ABC) and wore a StepWatch Activity Monitor for 7 consecutive d in the community. Subjects were subsequently stratified as low ( <3,000 steps/d) or high (>/=3,000) steps/d) activity groups. Balance confidence was significantly lower among the low activity weekday group (LAG, 70...
2016: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/27894500/prediction-of-massive-transfusion-in-trauma
#3
REVIEW
Paul M Cantle, Bryan A Cotton
Hemorrhage is the leading cause of preventable death in trauma. Damage control resuscitation relies on permissive hypotension, minimizing crystalloid use, and early implementation of massive transfusion protocols with established blood component ratios. These protocols improve the survival of the severely injured patient. Trauma physicians must quickly and accurately predict when a massive transfusion protocol should be activated. Several validated transfusion scores have been developed for this purpose. Many of these scores are useful for resuscitation research...
January 2017: Critical Care Clinics
https://www.readbyqxmd.com/read/27880801/ampa-receptor-antagonist-nbqx-decreased-seizures-by-normalization-of-perineuronal-nets
#4
Wen Chen, Yan-Shuang Li, Jing Gao, Xiao-Ying Lin, Xiao-Hong Li
Epilepsy is a serious brain disorder with diverse seizure types and epileptic syndromes. AMPA receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzoquinoxaline-2,3-dione (NBQX) attenuates spontaneous recurrent seizures in rats. However, the anti-epileptic effect of NBQX in chronic epilepsy model is poorly understood. Perineuronal nets (PNNs), specialized extracellular matrix structures, surround parvalbumin-positive inhibitory interneurons, and play a critical role in neuronal cell development and synaptic plasticity...
2016: PloS One
https://www.readbyqxmd.com/read/27868356/the-impact-of-the-dementia-abc-educational-programme-on-competence-in-person-centred-dementia-care-and-job-satisfaction-of-care-staff
#5
Anne Marie Mork Rokstad, Betty Sandvik Døble, Knut Engedal, Øyvind Kirkevold, Jūratė Šaltytė Benth, Geir Selbaek
AIM AND OBJECTIVES: The objective of the study was to evaluate the impact of the Dementia ABC educational programme on the participants' competence in person-centred care and on their level of job satisfaction. BACKGROUND: The development of person-centred care for people with dementia is highly recommended, and staff training that enhances such an approach may positively influence job satisfaction and the possibility of recruiting and retaining competent care staff...
November 20, 2016: International Journal of Older People Nursing
https://www.readbyqxmd.com/read/27865099/assessing-symptoms-during-comprehensive-interventions-for-young-children-with-autism-spectrum-disorder-development-and-preliminary-analysis-of-the-autism-behaviour-coding-system-abcs
#6
Diana Dima, Olga Lazari, Klaus Schmeck, René Spiegel, Anja Brönnimann, Kirstin Goth, Evelyn Herbrecht
The aims of this paper are to present the Autism Behaviour Coding System (ABCS), a novel, video-based observational instrument for assessing core autism symptoms during intensive early interventions in autism spectrum disorder (ASD), to provide preliminary data on its psychometric characteristics and to discuss its clinical utility. Video recordings of child-therapist interactions during the 'Frühintervention bei autistischen Störungen' (FIAS) were coded by treatment-independent raters who were blind with respect to the temporal order of the sequences...
November 10, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27861540/thrombolysis-in-stroke-within-30-minutes-results-of-the-acute-brain-care-intervention-study
#7
Sanne M Zinkstok, Ludo F Beenen, Jan S Luitse, Charles B Majoie, Paul J Nederkoorn, Yvo B Roos
BACKGROUND AND PURPOSE: Time is brain: benefits of intravenous thrombolysis (IVT) in ischemic stroke last for 4.5 hours but rapidly decrease as time progresses following symptom onset. The goal of the Acute Brain Care (ABC) intervention study was to reduce the door-to-needle time (DNT) to ≤30 minutes by optimizing in-hospital stroke treatment. METHODS: We performed a single-centre before (pre-intervention period: 2000-2005) versus after (post-intervention period: 2006-2012) comparison in a cohort of consecutive patients treated with IVT...
2016: PloS One
https://www.readbyqxmd.com/read/27860346/dietary-intakes-in-children-born-small-for-gestational-age-and-appropriate-for-gestational-age-a-longitudinal-study
#8
Clare R Wall, Rinki Murphy, Karen E Waldie, Edwin A Mitchell, John M D Thompson
Children born small for gestational age (SGA) have an increased risk of cardiovascular disease (CVD) and associated risk factors in later life; however, little is known about their dietary intakes. The objective of this study was to assess dietary intakes in SGA and appropriate for gestational age (AGA) at 3.5, 7, and 11 years. The Auckland Birthweight Collaborative Study is a longitudinal case-control study of children born at term (n = 871). Children were assessed at 3.5 (n = 550), 7 (n = 591), and 11 (n = 620) years of age...
November 15, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27858674/reliability-and-validity-of-the-turkish-version-of-activities-specific-balance-confidence-scale-in-symptomatic-knee-osteoarthritis
#9
Nurdan Paker, Derya Bugdayci, Ufuk Basaran Demircioglu, Feride Sabirli, Sevda Ozel
BACKGROUND: Activities-specific Balance Confidence (ABC) scale is a well known tool to evaluate the functional balance. Balance impairment may accompany to knee osteoarthritis. OBJECTIVE: The aim was to investigate the reliability and validity of the Turkish version of ABC in knee osteoarthritis. METHODS: Forty-nine patients with knee osteoarthritis were included. All the participants were evaluated by ABC and Berg Balance Scale (BBS). Knee Injury and Osteoarthritis Outcome Score (KOOS) was used for the assessment of the knee related condition...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27857999/do-age-and-anticoagulants-affect-the-natural-history-of-acute-subdural-hematomas
#10
Brandon P Lucke-Wold, Ryan C Turner, Darnell Josiah, Chelsea Knotts, Sanjay Bhatia
Acute subdural hematoma is a serious complication following traumatic brain injury. Large volume hematomas or those with underlying brain injury can cause mass effect, midline shift, and eventually herniation of the brain. Acute subdural hematomas in the young are associated with high-energy trauma and often have underlying contusions, while acute subdural hematomas in the elderly are associated with minor trauma and an absence of underlying contusions, even though the elderly are more likely to be on anticoagulants or anti-platelet therapy...
2016: Arch Emerg Med Crit Care
https://www.readbyqxmd.com/read/27857100/factors-affecting-the-complexity-of-dental-implant-restoration-what-is-the-current-evidence-and-guidance
#11
S P Wright, J Hayden, J A Lynd, K Walker-Finch, J Willett, C Ucer, S D Speechley
Objectives The aim of this paper is to identify the factors that affect the complexity of implant restoration and to explore the indices that help us to assess it. With this knowledge the growing number of clinicians restoring dental implants will have a better understanding of the available guidance and evidence base, and the differing levels of competence required.Study design A literature review was conducted. The selection of publications reporting on complexity was based on predetermined criteria and was agreed upon by the authors...
November 18, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27826188/response-to-depression-treatment-in-the-aging-brain-care-medical-home-model
#12
Michael A LaMantia, Anthony J Perkins, Sujuan Gao, Mary G Austrom, Cathy A Alder, Dustin D French, Debra K Litzelman, Ann H Cottingham, Malaz A Boustani
OBJECTIVE: To evaluate the effect of the Aging Brain Care (ABC) Medical Home program's depression module on patients' depression severity measurement over time. DESIGN: Retrospective chart review. SETTING: Public hospital system. PARTICIPANTS: Patients enrolled in the ABC Medical Home program between October 1, 2012 and March 31, 2014. METHODS: The response of 773 enrolled patients who had multiple patient health questionnaire-9 (PHQ-9) scores recorded in the ABC Medical Home program's depression care protocol was evaluated...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27818787/reconstructing-contact-network-parameters-from-viral-phylogenies
#13
Rosemary M McCloskey, Richard H Liang, Art F Y Poon
Models of the spread of disease in a population often make the simplifying assumption that the population is homogeneously mixed, or is divided into homogeneously mixed compartments. However, human populations have complex structures formed by social contacts, which can have a significant influence on the rate of epidemic spread. Contact network models capture this structure by explicitly representing each contact which could possibly lead to a transmission. We developed a method based on approximate Bayesian computation (ABC), a likelihood-free inference strategy, for estimating structural parameters of the contact network underlying an observed viral phylogeny...
July 2016: Virus Evolution
https://www.readbyqxmd.com/read/27811534/performance-in-trauma-resuscitation-at-an-urban-tertiary-level-i-pediatric-trauma-center
#14
Payal Kadia Gala, Kevin Osterhoudt, Sage R Myers, Mariel Colella, Aaron Donoghue
BACKGROUND: The role of the surveyor in trauma resuscitations is to identify life-threatening injuries and is meant to be conducted by a set protocol for every patient. Optimal performance of the trauma survey is known to be a challenge in pediatric trauma resuscitation. A postulated reason for this observation is that many trainees, such as pediatric residents, who perform the trauma survey have minimal experience and do not have formal advanced trauma life support training. The assessment of factors that may be obstacles in performing the trauma survey has not been studied robustly...
November 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27811155/olfaction-is-related-to-motor-function-in-older-adults
#15
Qu Tian, Susan M Resnick, Stephanie A Studenski
BACKGROUND: Among older adults, both olfaction and motor function predict future cognitive decline and dementia, suggesting potential shared causal pathways. However, it is not known whether olfactory and motor function are independently related in late life. METHODS: We assessed cross-sectional associations of olfaction with motor and cognitive function, using concurrent data on olfactory function, mobility, balance, fine motor function, manual dexterity, and cognition in 163 Baltimore Longitudinal Study of Aging participants aged 60 and older without common neurological diseases (n = 114 with available cognitive data)...
November 3, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27810665/cross-cultural-validation-of-the-falls-efficacy-scale-international-fes-i-in-portuguese-community-dwelling-older-adults
#16
Daniela Figueiredo, Sónia Santos
The Falls Efficacy Scale-International (FES-I) is a highly reliable instrument to assess fear of falling among older population. This study aimed to develop a European Portuguese version of the FES-I (FES-I(P)) and analyse its psychometric properties in terms of internal consistency, test-retest reliability, concurrent and convergent validity. A cross-sectional study was conducted. Data collection integrated a socio-demographic questionnaire which included falls history and presence/absence of fear of falling, the Activities-specific Balance Confidence Scale (ABC), the Hospital Anxiety and Depression Scale (HADS), the Timed Up and Go (TUG) and the Five Times Sit to Stand Test (FTSST)...
January 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27805538/-effectiveness-of-the-assessment-of-burden-of-copd-tool-a-cluster-randomised-controlled-trial
#17
O C P van Schayck, A H M Slok, D Kotz, G van Breukelen, N H Chavannes, M P M H Rutten-van Mölken, H A M Kerstjens, T van der Molen, G M Asijee, P N R Dekhuijzen, S Holverda, P L Salomé, L M A Goossens, M Twellaar, J C C M In 't Veen
OBJECTIVE: Assessment of the effectiveness of the Assessment of Burden of COPD (ABC) tool on disease-specific quality of life in patients with Chronic Obstructive Pulmonary Disease (COPD). DESIGN: Cluster-randomised controlled trial. METHOD: This concerned a trial in 39 Dutch primary care practices and 17 hospitals, involving 357 patients with COPD (postbronchodilator FEV1/FVC ratio < 0.7) aged ≥ 40 years. Healthcare providers were randomized to an intervention or control group...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27789239/minimal-clinically-important-difference-of-berg-balance-scale-in-people-with-multiple-sclerosis
#18
Elisa Gervasoni, Johanna Jonsdottir, Angelo Montesano, Davide Cattaneo
OBJECTIVE: To identify the Minimal Clinically Important Difference (MCID) to define clinically meaningful patient's improvement on the Berg Balance Scale (BBS) in People with Multiple Sclerosis (PwMS) in response to rehabilitation. DESIGN: Cohort study SETTING: Neurorehabilitation institute. PARTICIPANTS: 110 PwMS participated in this study. INTERVENTIONS: This study is comprised of inpatients and outpatients that participated in research on balance and gait rehabilitation...
October 24, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27779107/the-components-of-huang-lian-jie-du-decoction-act-synergistically-to-exert-protective-effects-in-a-rat-ischemic-stroke-model
#19
Qian Zhang, Junsong Wang, Chao Zhang, Shanting Liao, Pei Li, Dingqiao Xu, Yan Lv, Minghua Yang, Lingyi Kong
Huang-Lian-Jie-Du-Decoction (HLJDD, Oren-gedoku-to in Japanese) is commonly used in traditional Chinese medicine (TCM) to treat ischemic stroke. This study investigated the efficacy of various combinations of the major components of HLJDD, berberine (A), baicalin (B), and jasminoidin (C), on the treatment of ischemic stroke modeled by middle cerebral artery occlusion (MCAO) in rats. The effects of A, B and C individually and their combinations were investigated using proton nuclear magnetic resonance (1H NMR)-based metabolomics complemented with neurologic deficit scoring, infarct volume measurement, biochemistry, histopathology and immunohistochemistry, as well as quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting...
October 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27760757/assessment-of-cd37-b-cell-antigen-and-cell-of-origin-significantly-improves-risk-prediction-in-diffuse-large-b-cell-lymphoma
#20
Zijun Y Xu-Monette, Ling Li, John C Byrd, Kausar J Jabbar, Ganiraju C Manyam, Charlotte Maria de Winde, Michiel van den Brand, Alexandar Tzankov, Carlo Visco, Jing Wang, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L Richards, Eric D Hsi, William W L Choi, Jooryung Huh, Maurilio Ponzoni, Andrés J M Ferreri, Michael B Møller, Ben M Parsons, Jane N Winter, Michael Wang, Fredrick B Hagemeister, Miguel A Piris, J Han van Krieken, L Jeffrey Medeiros, Yong Li, Annemiek B van Spriel, Ken H Young
CD37 (tetraspanin TSPAN26) is a B-cell surface antigen widely expressed on mature B-cells. CD37 is involved in immune regulation and tumor suppression but its function has not been fully elucidated. In this study, we assessed CD37 expression in de novo diffuse large B-cell lymphoma (DLBCL), and investigated its clinical and biologic significance in 773 patients treated with rituximab-CHOP and 231 patients treated with CHOP chemotherapy. We found CD37 loss (CD37(-)) in ~60% of DLBCL predicted significantly decreased survival rates in R-CHOP-treated patients, independent of the International Prognostic Index (IPI), germinal-center-B-cell-like (GCB)/activated-B-cell-like (ABC) cell-of-origin, nodal/extranodal primary origin, and the prognostic factors associated with CD37(-), including TP53 mutation, NF-κB(high), Myc(high), p-STAT3(high), survivin(high), p63(-), and BCL6 translocation...
October 19, 2016: Blood
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