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https://www.readbyqxmd.com/read/29449954/metabotropic-glutamate-receptor-5-tracer-18-f-fpeb-displays-increased-binding-potential-in-postcentral-gyrus-and-cerebellum-of-male-individuals-with-autism-a-pilot-pet-study
#1
S Hossein Fatemi, Dean F Wong, James R Brašić, Hiroto Kuwabara, Anil Mathur, Timothy D Folsom, Suma Jacob, George M Realmuto, José V Pardo, Susanne Lee
Background: Autism is a neurodevelopmental disorder that is first manifested during early childhood. Postmortem experiments have identified significantly elevated expression of metabotropic glutamate receptor 5 (mGluR5) in cerebellar vermis and prefrontal cortex of individuals with autism. Methods: In the current study we employed the mGluR5 tracer [ 18 F]-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ([ 18 F]-FPEB) to quantify mGluR5 binding in vivo in adults with autism vs...
2018: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/29441487/prior-antiplatelet-therapy-is-not-associated-with-larger-hematoma-volume-or-hematoma-growth-in-intracerebral-hemorrhage
#2
Verena van Ginneken, Patricia Engel, Jochen B Fiebach, Heinrich J Audebert, Christian H Nolte, Andrea Rocco
Hematoma volume (HV) and hematoma growth (HG) predict mortality and poor outcome in intracerebral hemorrhage (ICH). While the influence of oral anticoagulation on HV, HG and outcome is well established, the effect of prior antiplatelet therapy (APT) remains uncertain. We retrospectively examined data from all patients with acute, primary ICH, and baseline head CT admitted to our department between January 2005 and February 2014. HV were calculated by ABC/2 method. HG was defined as present if HV increased between baseline and follow-up CT ≥ 30% or ≥ 6 mL...
February 14, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29419568/recent-abacavir-use-increases-risk-for-types-1-and-2-myocardial-infarctions-among-adults-with-hiv
#3
Richard A Elion, Keri N Althoff, Jinbing Zhang, Richard D Moore, Stephen J Gange, Mari M Kitahata, Heidi M Crane, Daniel R Drozd, James H Stein, Marina B Klein, Joseph J Eron, Michael J Silverberg, William C Mathews, Amy C Justice, Timothy R Sterling, Charles S Rabkin, Angel M Mayor, Daniel B Klein, Michael A Horberg, Ronald J Bosch, Oghenowede Eyawo, Frank J Palella
BACKGROUND: There is persistent confusion as to whether abacavir (ABC) increases the risk for myocardial infarction (MI), and whether such risk differs by Type 1 (T1MI) or 2 (T2MI) MI in adults with HIV. METHODS: Incident MIs in NA-ACCORD participants were identified from 2001 to 2013. Discrete time marginal structural models addressed channeling biases and time-dependent confounding to estimate crude (HR) and adjusted hazard ratios (aHR) and 95% confidence intervals; analyses were performed for T1MI and T2MI separately...
February 6, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29414299/predicting-falls-in-multiple-sclerosis-do-electrophysiological-measures-have-a-better-predictive-accuracy-compared-to-clinical-measures
#4
Somasundaram Aadhimoolam Chinnadurai, Divya Gandhirajan, Avathvadi Venkatesan Srinivasan, Bhanu Kesavamurthy, Lakshmi Narasimhan Ranganathan, Vijaya Pamidimukkala
BACKGROUND: The risk of falls in people with Multiple Sclerosis (MS) is much greater than that of the general population due to impaired coordination, gait, sensation, muscle tone, strength, and cognition. These MS related falls hamper the day to day living of these individuals and are one of the prime factors aggravating the disease related morbidity. The fear of falling itself may make these individuals more dependent and hinder their professional and leisurely activities. Hence, the significance of identifying individuals who are at risk of falling and instituting preventive counter-measures cannot be overemphasized...
February 2, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29406900/symptomatic-orthostatic-hypotension-in-parkinson-s-disease-patients-prevalence-associated-factors-and-its-impact-on-balance-confidence
#5
Siranan Klanbut, Siripan Phattanarudee, Supakit Wongwiwatthananukit, Chuthamanee Suthisisang, Roongroj Bhidayasiri
BACKGROUND: Orthostatic hypotension (OH) is a commonly reported sign of the cardiovascular autonomic dysfunctions associated with Parkinson's disease (PD). Patients might suffer from a variety of the clinical symptoms of OH, including dizziness, lightheadedness, or problems with vision and fatigue. OBJECTIVES: To determine the prevalence of, and factors associated with, symptomatic orthostatic hypotension (OH) in Parkinson's disease (PD) and to identify any relationships between the clinical symptoms of OH and balance confidence in this patient population...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29406430/abacavir-lamivudine-and-tenofovir-emtricitabine-in-pregnant-women-with-hiv-laboratory-and-clinical-outcomes-in-an-observational-national-study
#6
Marco Floridia, Carmela Pinnetti, Marina Ravizza, Giulia Masuelli, Carlo Personeni, Matilde Sansone, Anna Degli Antoni, Giovanni Guaraldi, Arsenio Spinillo, Beatrice Tassis, Serena Dalzero, Giuseppina Liuzzi, Enrica Tamburrini
BACKGROUND: Abacavir-lamivudine (ABC/3TC) and tenofovir-emtricitabine (TDF/FTC) represent in the guidelines of several countries, including Italy and United States, the preferred nucleoside/nucleotide backbones of antiretroviral regimens. We assessed their profile in pregnancy using data from a national observational study. METHODS: Laboratory measures (CD4, HIV-RNA, lipid profile, glucose, haemoglobin, ALT) and pregnancy outcomes (preterm delivery, low birthweight, nonelective cesarean section, birthweight Z-score, congenital defects, HIV transmission, maternal weight gain, pregnancy complications) were compared following prenatal exposure to ABC/3TC or TDF/FTC...
February 5, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29398167/severity-scores-in-trauma-patients-admitted-to-icu-physiological-and-anatomic-models
#7
L Serviá, M Badia, N Montserrat, J Trujillano
INTRODUCTION: The goals of this project were to compare both the anatomic and physiologic severity scores in trauma patients admitted to intensive care unit (ICU), and to elaborate mixed statistical models to improve the precision of the scores. METHODS: A prospective study of cohorts. The combined medical/surgical ICU in a secondary university hospital. Seven hundred and eighty trauma patients admitted to ICU older than 16 years of age. Anatomic models (ISS and NISS) were compared and combined with physiological models (T-RTS, APACHE II [APII], and MPM II)...
February 2, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29385740/effects-of-combining-medication-and-pivotal-response-treatment-on-aberrant-behavior-in-children-with-autism-spectrum-disorder
#8
Mohammad Rezaei, AliReza Moradi, Mehdi Tehrani-Doost, HamidReza Hassanabadi, Reza Khosroabadi
Abstract: The purpose of this study was to investigate the effects of combined risperidone (RIS) and pivotal response treatment (PRT) on children with autism spectrum disorder (ASD). A total of 34 children diagnosed with ASD according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V) (mean age of 12.36 years) were randomly assigned to either of two groups; the first group (n = 17) received combined PRT-RIS while the second group (n = 17) received RIS only. Behavioral problems were evaluated with the Aberrant Behavior Checklist (ABC), whereas global improvement (GI) was measured with the Clinical Global Impressions (CGI)...
January 30, 2018: Children
https://www.readbyqxmd.com/read/29381716/quantitative-mri-in-early-intervertebral-disc-degeneration-t1rho-correlates-better-than-t2-and-adc-with-biomechanics-histology-and-matrix-content
#9
Cornelis P L Paul, Theodoor H Smit, Magda de Graaf, Roderick M Holewijn, Arno Bisschop, Peter M van de Ven, Margriet G Mullender, Marco N Helder, Gustav J Strijkers
INTRODUCTION: Low-back pain (LBP) has been correlated to the presence of intervertebral disc (IVD) degeneration on T2-weighted (T2w) MRI. It remains challenging, however, to accurately stage degenerative disc disease (DDD) based on T2w MRI and measurements of IVD height, particularly for early DDD. Several quantitative MRI techniques have been introduced to detect changes in matrix composition signifying early DDD. In this study, we correlated quantitative T2, T1rho and Apparent Diffusion Coefficient (ADC) values to disc mechanical behavior and gold standard early DDD markers in a graded degenerated lumbar IVD caprine model, to assess their potential for early DDD detection...
2018: PloS One
https://www.readbyqxmd.com/read/29373905/significance-of-dna-replication-licensing-proteins-mcm2-mcm5-and-cdc6-p16-and-p63-as-markers-of-premalignant-lesions-of-the-uterine-cervix-its-usefulness-to-predict-malignant-potential
#10
V N Saritha, V S Veena, K M Jagathnath Krishna, Thara Somanathan, K Sujathan
Cervical cancer continues to be a leading cancer among women in many parts of the world. Nation-wide screening with the Pap smear has not been implemented in India due to the lack of adequately trained cytologists. Identification of biomarkers to predict malignant potential of the identified low risk lesions is essential to avoid excessive retesting and follow up. The current study analyzed the expression patterns of DNA replication licensing proteins, proliferation inhibitor protein p16INK4A and tumor suppresser protein p63 in cervical tissues and smears to assess the ability of these proteins to predict progression...
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29370583/immune-gene-expression-and-response-to-chemotherapy-in-advanced-breast-cancer
#11
Theodoros Foukakis, John Lövrot, Alexios Matikas, Ioannis Zerdes, Julie Lorent, Nick Tobin, Chikako Suzuki, Suzanne Egyházi Brage, Lena Carlsson, Zakaria Einbeigi, Barbro Linderholm, Niklas Loman, Martin Malmberg, Mårten Fernö, Lambert Skoog, Jonas Bergh, Thomas Hatschek
BACKGROUND: Transcriptomic profiles have shown promise as predictors of response to neoadjuvant chemotherapy in breast cancer (BC). This study aimed to explore their predictive value in the advanced BC (ABC) setting. METHODS: In a Phase 3 trial of first-line chemotherapy in ABC, a fine needle aspiration biopsy (FNAB) was obtained at baseline. Intrinsic molecular subtypes and gene modules related to immune response, proliferation, oestrogen receptor (ER) signalling and recurring genetic alterations were analysed for association with objective response to chemotherapy...
January 25, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29346081/reported-balance-confidence-and-movement-reinvestment-of-younger-knee-replacement-patients-are-more-like-younger-healthy-individuals-than-older-patients
#12
Brian D Street, Allan Adkin, William Gage
This study focused on differences between the rapidly growing younger (<65 years old) and older (>65 years old) total knee replacement (TKR) patients for measures of balance confidence, movement reinvestment, and functional mobility. Fifty-nine participants, including twenty-nine primary unilateral TKR patients (six months post-TKR) formed the four experimental groups: 1) Younger TKR Patient (YP), 2) Younger Control (YC), 3) Older TKR Patient (OP), and 4) Older Control (OC). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Oxford Knee Score (OKS), Activities-specific Balance Confidence scale (ABC), the Movement-Specific Reinvestment Scale (MSRS), and the Timed Up and Go (TUG) test were measured...
January 11, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29324255/aberrant-autistic-and-food-related-behaviors-in-adults-with-prader-willi-syndrome-the-comparison-between-young-adults-and-adults
#13
Hiroyuki Ogata, Hiroshi Ihara, Masao Gito, Masayuki Sayama, Nobuyuki Murakami, Tadayuki Ayabe, Yuji Oto, Toshiro Nagai, Kazutaka Shimoda
This study aims to explore the differences of age as well as genotype in regards to the severity of behavioral symptoms in Prader-Willi syndrome (PWS), with emphasis on the comparison between youngadults and adults.The Food Related Problem Questionnaire (FRPQ), the Aberrant Behavior Checklist Japanese Version (ABC-J), and the Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS) were administered to 46 PWS patients, including 33 young adults (ages 18-28) and 13 adults(ages 30-45). To examine the differences between young adults and adults, Mann-Whitney U tests were conducted...
January 8, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29310586/available-bed-sided-comprehensive-abc-score-to-a-diagnosis-of-methicillin-resistant-staphylococcus-aureus-infection-a-derivation-and-validation-study
#14
Nori Yoshioka, Matsuo Deguchi, Hideharu Hagiya, Hisao Yoshida, Norihisa Yamamoto, Shoji Hashimoto, Yukihiro Akeda, Kazunori Tomono
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infections continue to be a leading problem in health care facilities worldwide. METHODS: This single-center retrospective cohort study consisted of a derivation phase and a validation phase. The derivation phase included all patients admitted to Osaka University Hospital between May 2010 and April 2011. We proposed a provisional available, bed-sided, comprehensive (ABC) score, and evaluated its accuracy using the clinical diagnosis as a reference...
January 8, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29299753/factors-associated-with-the-outcome-of-very-elderly-patients-with-large-hemispheric-infarction-treated-with-medical-management-only
#15
Sudhir Datar, Christopher McLouth, Patrick Reynolds
BACKGROUND: Large ischemic stroke in the very elderly population is presumed to invariably carry a poor prognosis and clinicians may refrain from continuing intensive care. Many elderly patients are not surgical candidates, and there is a paucity of data outlining the real-world outcomes of continued medical management. Our objective is to identify the factors associated with the outcome of very elderly patients with large hemispheric infarction (LHI) treated with medical management alone...
January 3, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29282261/abc-index-quantifying-experienced-burden-of-copd-in-a-discrete-choice-experiment-and-predicting-costs
#16
Lucas Ma Goossens, Maureen Pmh Rutten-van Mölken, Melinde Rs Boland, Bas Donkers, Marcel F Jonker, Annerika Hm Slok, Philippe L Salomé, Onno Cp van Schayck, Johannes Ccm In 't Veen, Elly A Stolk
OBJECTIVE: The Assessment of Burden of COPD (ABC) tool supports shared decision making between patient and caregiver. It includes a coloured balloon diagram to visualise patients' scores on burden indicators. We aim to determine the importance of each indicator from a patient perspective, in order to calculate a weighted index score and investigate whether that score is predictive of costs. DESIGN: Discrete choice experiment. SETTING AND PARTICIPANTS: Primary care and secondary care in the Netherlands...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29276530/inattention-and-hyperactivity-in-association-with-autism-spectrum-disorders-in-the-charge-study
#17
Kristen Lyall, Julie B Schweitzer, Rebecca J Schmidt, Irva Hertz-Picciotto, Marjorie Solomon
Background: Attention deficits in young children with autism spectrum disorder (ASD) are not well understood. This study sought to determine: 1) the prevalence of ADHD symptoms in young children with ASD, typical development (TD), and developmental delay (DD) and 2) the association between ADHD symptoms and cognitive and behavioral functioning in children with ASD. Method: ADHD symptoms, defined according to Aberrant Behavior Checklist (ABC) hyperactivity subscale scores, were compared across children aged 2-5 from a large case-control study with ASD (n=548), TD (n=423), and DD (n=180)...
March 2017: Research in Autism Spectrum Disorders
https://www.readbyqxmd.com/read/29275071/very-preterm-born-children-at-early-school-age-healthcare-therapies-and-educational-provisions
#18
S van Veen, C S H Aarnoudse-Moens, J Oosterlaan, L van Sonderen, T R de Haan, A H van Kaam, A G van Wassenaer-Leemhuis
AIM: To explore changes in motor and cognitive outcomes in very preterm (VP; gestational age<30weeks) born children between ages five and six years, and to determine whether changes in these outcomes were associated with the use of healthcare therapies and educational provisions. STUDY DESIGN: Single-center observational cohort study. Five-year-old VP born children of a one-year-cohort of our neonatal follow-up program (N=90) were invited for re-assessments at age six...
December 21, 2017: Early Human Development
https://www.readbyqxmd.com/read/29262471/-correlation-between-serum-25-hydroxyvitamin-d-level-and-core-symptoms-of-autism-spectrum-disorder-in-children
#19
H Y Dong, B Wang, H H Li, L Shan, F Y Jia
Objective: To explore the relationship between serum 25-hydroxyvitamin D levels and core symptoms of autism spectrum disorder (ASD) in children. Method: In this cross-sectional study, ASD children 4 to 6 years of age who were diagnosed in Department of Developmental and Behavioral Pediatrics, First Hospital of Jilin university from January to May 2017 were assigned to ASD group, and children for routine growth and development assessment in Jilin province were assigned to control group. The two groups were well matched for age and sex, and none of them had received vitamin D supplementation...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29262469/-association-between-behavioral-problems-and-gastrointestinal-disorders-among-children-with-autism-spectrum-disorder
#20
J Zhu, M Guo, T Yang, X Lai, Y Y Lei, M L He, J Chen, T Y Li
Objective: To investigate the relationship between gastrointestinal disorders (GID) and core symptoms or behavioral problems among the children with autism spectrum disorder (ASD) . Method: Totally 328 children with ASD and 202 normal controls were enrolled in this cross-sectional study from August 2013 to October 2016. The information about the gastrointestinal disorders, behavioral and emotional problems was collected by using questionnaires. Childhood Autism Rating Scale (CARS), Autism Behavior Checklist (ABC) were used to assess the core symptoms of the children with ASD...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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