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https://www.readbyqxmd.com/read/28093855/typical-and-atypical-appearance-of-early-onset-alzheimer-s-disease-a-clinical-neuroimaging-and-neuropathological-study-symposium-fundamentals-learned-from-diversity-among-typical-and-atypical-appearances
#1
Shinobu Kawakatsu 川勝 忍, Ryota Kobayashi, Hiroshi Hayashi
The International Working Group (IWG) has classified Alzheimer's disease (AD) as two different types, the typical form and the atypical form, but clinicopathological studies of atypical AD are limited. Because atypical AD cases usually present with early-onset dementia, we investigated 12 patients with early-onset AD, including two patients with typical AD and 10 patients with atypical AD. Of these patients, six had the posterior variant, three had the frontal variant and one had the logopenic variant mixed with semantic dementia...
January 17, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28079635/influences-of-age-obesity-and-adverse-drug-effects-on-balance-and-mobility-testing-scores-in-ambulatory-older-adults
#2
Eric Anson, Elizabeth Thompson, Brian L Odle, John Jeka, Zachary F Walls, Peter C Panus
BACKGROUND AND PURPOSE: The adverse effects of drugs may influence results on tests of mobility and balance, but the drug-specific impact is not identified when using these tests. We propose that a quantitative drug index (QDI) will assist in assessing fall risk based on these tests, when combined with other fall risk variables. METHODS: Fifty-seven community-dwelling older adults who could walk independently on a treadmill and had Mini-Mental State Examination (MMSE) scores equal to or greater than 24 participated...
January 10, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28066525/the-effect-of-transfemoral-interface-design-on-gait-speed-and-risk-of-falls
#3
Jason T Kahle, Tyler D Klenow, William J Sampson, M Jason Highsmith
Falls and diminished walking capacity are impairments common in persons with transfemoral amputation (TFA). Reducing falls and optimizing walking capacity through such means as achieving a more normal gait speed and community ambulation should be considered when formulating the prosthetic prescription. Because walking capacity and balance confidence are compromised with TFA, these outcomes should be considered when evaluating interfaces for transfemoral prosthetic users. The purpose of this study was to compare the effect of TFA interface design on walking capacity and balance confidence A retrospective cohort design was utilized involving unilateral TFA patients who used ischial ramus containment (IRC) and High-Fidelity (HiFi) interfaces (independent variables)...
September 2016: Technology and Innovation
https://www.readbyqxmd.com/read/28063676/early-predictors-for-massive-transfusion-in-older-adult-severe-trauma-patients
#4
Takao Ohmori, Taisuke Kitamura, Junko Ishihara, Hirokazu Onishi, Tsuyoshi Nojima, Kotaro Yamamoto, Ryu Tamura, Kentaro Muranishi, Toshiyuki Matsumoto, Takamitsu Tokioka
BACKGROUND: Many scoring systems for the early prediction of the need for massive transfusion (MT) have been reported; in most of these, vital signs are regarded as important. However, the validity of these scoring systems in older patients remains unclear because older trauma patients often present with normal vital signs. In this study, we investigated the effectiveness of previously described scoring systems, as well as risk factors that can provide early prediction of the need for MT in older severe trauma patients...
December 29, 2016: Injury
https://www.readbyqxmd.com/read/28056297/-potential-mechanism-and-prognostic-value-of-promoter-methylation-of-prdm1-gene-in-diffuse-large-b-cell-lymphoma
#5
X Y Zhang, Z P Ma, W L Cui, R Chen, Abulajiang Glinaer, N Miao, X X Li
Objective: To investigate PRDM1 gene methylation status, immune classification and their prognostic significance in diffuse large B cell lymphoma (DLBCL). Methods: Immunohistochemical (IHC) staining for CD20, CD10, bcl-2, bcl-6, PRDM1/Blimp-1 and MUM1 was carried out in 100 cases of DLBCL specimens and 20 reactive lymphoid proliferation samples. All patients were classified into germinal center B cell-like (GCB) and activated B cell-like (ABC) subtype according to Hans' algorithmin. PRDM1 gene methylation was detected by methylation-specific PCR (MSP) and its relationship with clinicopathologic parameters was analyzed...
December 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28039314/olfaction-and-risk-of-dementia-in-a-biracial-cohort-of-older-adults
#6
Kristine Yaffe, Daniel Freimer, Honglei Chen, Keiko Asao, Andrea Rosso, Susan Rubin, Greg Tranah, Steve Cummings, Eleanor Simonsick
OBJECTIVE: Prior studies indicate that olfactory function may be an early marker for cognitive impairment, but the body of evidence has been largely restricted to white populations. METHODS: We studied 2,428 community-dwelling black and white older adults (baseline age 70-79 years) without dementia enrolled in the Health, Aging, and Body Composition (Health ABC) study. Olfaction was measured as odor identification (OI) with the 12-item Cross Cultural Smell Identification Test in year 3...
December 30, 2016: Neurology
https://www.readbyqxmd.com/read/28033546/alterations-in-balance-and-mobility-in-people-with-epilepsy
#7
Carlos R Camara-Lemarroy, Daniela Ortiz-Zacarías, Juan J Peña-Avendaño, Ingrid Estrada-Bellmann, Héctor J Villarreal-Velázquez, Marco A Díaz-Torres
PURPOSE: People with epilepsy (PWE) are burdened by physical disability and side effects of antiepileptic drugs (AED) such as drowsiness and blurred vision. These factors place them at risk for reduced mobility and falls. The purpose of this study was to evaluate mobility and balance in PWE. METHODS: This was a cross-sectional study of PWE and age- and sex-matched controls. We evaluated mobility and balance using the Timed Up and Go Test (TUG) and the Tinetti Mobility Test (TMT)...
December 26, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27992071/are-behaviour-problems-in-extremely-low-birth-weight-children-related-to-their-motor-ability
#8
Marcella Danks, Kate Cherry, Yvonne R Burns, Peter H Gray
AIM: Investigate if behaviour problems are independently related to mild motor impairment in 11-13 year old children born preterm with extremely low birth weight (ELBW). METHODS: The cross sectional study included 48 (27 male) non-disabled, otherwise healthy ELBW children (<1000g) and 55 (28 male) term born peers. Parents reported behaviour using the Child Behavior Checklist (CBCL). Children completed the Movement Assessment Battery for Children (Movement ABC)...
December 19, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27977519/a-cross-sectional-analysis-of-the-characteristics-of-individuals-with-parkinson-disease-who-avoid-activities-and-participation-due-to-fear-of-falling
#9
Merrill R Landers, Morgan Lopker, Molly Newman, Russell Gourlie, Spencer Sorensen, Rithea Vong
BACKGROUND AND PURPOSE: Avoidance behavior can have deleterious consequences on health and quality of life for persons with Parkinson disease (PD); for this reason, it is important to identify potentially mitigable characteristics. We compared the characteristics of individuals with PD who exhibit fear of falling (FOF) avoidance behavior with those who do not. METHODS: Fifty-nine participants with PD were classified as avoiders (n = 27) or nonavoiders (n = 32) by using the Fear of Falling Avoidance Behavior Questionnaire and compared across 5 domains: demographic characteristics; PD-specific symptoms (subtype, Movement Disorder Society-Unified Parkinson's Disease Rating Scale [MDS-UPDRS], Hoehn and Yahr Scale, Parkinson's Disease Questionnaire-39 [PDQ-39]); balance and falls (fall history, Berg Balance Scale [BBS], Activities-Specific Balance Confidence [ABC] Scale, Impact of Events Scale, Consequences of Falling Questionnaire [CoFQ]); physical performance (30 Second Sit-to-Stand Test, Timed Up and Go Test, physical activity monitoring); and psychological factors (Zung Anxiety Scale, Beck Depression Inventory [BDI])...
January 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/27935560/mobility-measures-differentiate-falls-risk-status-in-persons-with-multiple-sclerosis-an-exploratory-study
#10
Emerson Sebastião, Yvonne C Learmonth, Robert W Motl
BACKGROUND: Falls are of great concern among persons with multiple sclerosis (MS). OBJECTIVE: To examine differences in metrics of mobility, postural control, and cognition in persons with MS with distinct fall risk status; and to investigate predictors of fall risk group membership using discriminant analysis. METHODS: Forty-seven persons with MS completed the Activities-Balance Confidence (ABC) Scale and underwent a battery of assessments of mobility, balance, and cognition...
December 8, 2016: NeuroRehabilitation
https://www.readbyqxmd.com/read/27925044/application-of-prognostic-score-ipset-thrombosis-in-patients-with-essential-thrombocythemia-of-a-brazilian-public-service
#11
Luana Magalhães Navarro, Damila Cristina Trufelli, Debora Rodrigues Bonito, Auro Del Giglio, Patricia Weinschenker Bollmann
Introduction: In patients with essential thrombocythemia (ET), the vascular complications contribute to morbidity and mortality. To better predict the occurrence of thrombotic events, an International Prognostic Score for Thrombosis in Essential Thrombocythemia (IPSET-thrombosis) has recently been proposed. We present the application of this score and compare its results with the usual classification system. Method: We retrospectively evaluated the characteristics and risk factors for thrombosis of 46 patients with a diagnosis of ET seen in the last 6 years at Faculdade de Medicina do ABC (FMABC)...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27898155/balance-confidence-and-activity-of-community-dwelling-patients-with-transtibial-amputation
#12
Alena Mandel, Kailan Paul, Ruby Paner, Michael Devlin, Steve Dilkas, Tim Pauley
The purpose of this study was to examine the relationship between balance confidence and community-based physical activity. Twenty-two community-dwelling patients with right or left unilateral transtibial amputation who reported no falls in the past 6 mo completed the Activities-Specific Balance Confidence Scale (ABC) and wore a StepWatch Activity Monitor for 7 consecutive d in the community. Subjects were subsequently stratified as low ( <3,000 steps/d) or high (>/=3,000) steps/d) activity groups. Balance confidence was significantly lower among the low activity weekday group (LAG, 70...
2016: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/27894500/prediction-of-massive-transfusion-in-trauma
#13
REVIEW
Paul M Cantle, Bryan A Cotton
Hemorrhage is the leading cause of preventable death in trauma. Damage control resuscitation relies on permissive hypotension, minimizing crystalloid use, and early implementation of massive transfusion protocols with established blood component ratios. These protocols improve the survival of the severely injured patient. Trauma physicians must quickly and accurately predict when a massive transfusion protocol should be activated. Several validated transfusion scores have been developed for this purpose. Many of these scores are useful for resuscitation research...
January 2017: Critical Care Clinics
https://www.readbyqxmd.com/read/27880801/ampa-receptor-antagonist-nbqx-decreased-seizures-by-normalization-of-perineuronal-nets
#14
Wen Chen, Yan-Shuang Li, Jing Gao, Xiao-Ying Lin, Xiao-Hong Li
Epilepsy is a serious brain disorder with diverse seizure types and epileptic syndromes. AMPA receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzoquinoxaline-2,3-dione (NBQX) attenuates spontaneous recurrent seizures in rats. However, the anti-epileptic effect of NBQX in chronic epilepsy model is poorly understood. Perineuronal nets (PNNs), specialized extracellular matrix structures, surround parvalbumin-positive inhibitory interneurons, and play a critical role in neuronal cell development and synaptic plasticity...
2016: PloS One
https://www.readbyqxmd.com/read/27868356/the-impact-of-the-dementia-abc-educational-programme-on-competence-in-person-centred-dementia-care-and-job-satisfaction-of-care-staff
#15
Anne Marie Mork Rokstad, Betty Sandvik Døble, Knut Engedal, Øyvind Kirkevold, Jūratė Šaltytė Benth, Geir Selbaek
AIM AND OBJECTIVES: The objective of the study was to evaluate the impact of the Dementia ABC educational programme on the participants' competence in person-centred care and on their level of job satisfaction. BACKGROUND: The development of person-centred care for people with dementia is highly recommended, and staff training that enhances such an approach may positively influence job satisfaction and the possibility of recruiting and retaining competent care staff...
November 20, 2016: International Journal of Older People Nursing
https://www.readbyqxmd.com/read/27865099/assessing-symptoms-during-comprehensive-interventions-for-young-children-with-autism-spectrum-disorder-development-and-preliminary-analysis-of-the-autism-behaviour-coding-system-abcs
#16
Diana Dima, Olga Lazari, Klaus Schmeck, René Spiegel, Anja Brönnimann, Kirstin Goth, Evelyn Herbrecht
The aims of this paper are to present the Autism Behaviour Coding System (ABCS), a novel, video-based observational instrument for assessing core autism symptoms during intensive early interventions in autism spectrum disorder (ASD), to provide preliminary data on its psychometric characteristics and to discuss its clinical utility. Video recordings of child-therapist interactions during the 'Frühintervention bei autistischen Störungen' (FIAS) were coded by treatment-independent raters who were blind with respect to the temporal order of the sequences...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27861540/thrombolysis-in-stroke-within-30-minutes-results-of-the-acute-brain-care-intervention-study
#17
Sanne M Zinkstok, Ludo F Beenen, Jan S Luitse, Charles B Majoie, Paul J Nederkoorn, Yvo B Roos
BACKGROUND AND PURPOSE: Time is brain: benefits of intravenous thrombolysis (IVT) in ischemic stroke last for 4.5 hours but rapidly decrease as time progresses following symptom onset. The goal of the Acute Brain Care (ABC) intervention study was to reduce the door-to-needle time (DNT) to ≤30 minutes by optimizing in-hospital stroke treatment. METHODS: We performed a single-centre before (pre-intervention period: 2000-2005) versus after (post-intervention period: 2006-2012) comparison in a cohort of consecutive patients treated with IVT...
2016: PloS One
https://www.readbyqxmd.com/read/27860346/dietary-intakes-in-children-born-small-for-gestational-age-and-appropriate-for-gestational-age-a-longitudinal-study
#18
Clare R Wall, Rinki Murphy, Karen E Waldie, Edwin A Mitchell, John M D Thompson
Children born small for gestational age (SGA) have an increased risk of cardiovascular disease (CVD) and associated risk factors in later life; however, little is known about their dietary intakes. The objective of this study was to assess dietary intakes in SGA and appropriate for gestational age (AGA) at 3.5, 7, and 11 years. The Auckland Birthweight Collaborative Study is a longitudinal case-control study of children born at term (n = 871). Children were assessed at 3.5 (n = 550), 7 (n = 591), and 11 (n = 620) years of age...
November 15, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27858674/reliability-and-validity-of-the-turkish-version-of-activities-specific-balance-confidence-scale-in-symptomatic-knee-osteoarthritis
#19
Nurdan Paker, Derya Bugdayci, Ufuk Basaran Demircioglu, Feride Sabirli, Sevda Ozel
BACKGROUND: Activities-specific Balance Confidence (ABC) scale is a well known tool to evaluate the functional balance. Balance impairment may accompany to knee osteoarthritis. OBJECTIVE: The aim was to investigate the reliability and validity of the Turkish version of ABC in knee osteoarthritis. METHODS: Forty-nine patients with knee osteoarthritis were included. All the participants were evaluated by ABC and Berg Balance Scale (BBS). Knee Injury and Osteoarthritis Outcome Score (KOOS) was used for the assessment of the knee related condition...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27857999/do-age-and-anticoagulants-affect-the-natural-history-of-acute-subdural-hematomas
#20
Brandon P Lucke-Wold, Ryan C Turner, Darnell Josiah, Chelsea Knotts, Sanjay Bhatia
Acute subdural hematoma is a serious complication following traumatic brain injury. Large volume hematomas or those with underlying brain injury can cause mass effect, midline shift, and eventually herniation of the brain. Acute subdural hematomas in the young are associated with high-energy trauma and often have underlying contusions, while acute subdural hematomas in the elderly are associated with minor trauma and an absence of underlying contusions, even though the elderly are more likely to be on anticoagulants or anti-platelet therapy...
2016: Archives of Emergency Medicine and Critical Care
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