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https://www.readbyqxmd.com/read/29226652/a-pooled-analysis-of-the-clinical-utilities-of-long-non-coding-rna-based-molecular-signature-for-diffuse-large-b-cell-lymphoma
#1
Pei Xu, Xiaoli Chen, Panke Su
BACKGROUND: Long non-coding RNAs (lncRNAs) have been highlighted as promising biomarkers for several types of malignancies. The current meta-analysis sought to investigate the clinical value of lncRNA-based molecular signatures as biomarkers for diagnosis, subtype classification, and prognosis in diffuse large B cell lymphoma (DLBCL). METHODS: A systematic search of the online databases was carried out and data were retrieved by pairs of independent reviewers. Effect sizes of the diagnostic parameters were combined using a quantitative meta-analysis...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29209539/proposing-development-and-utility-of-a-mobility-composite-measure-in-patients-with-a-neurologic-disorder
#2
Chad Swank, Sattam Almutairi, Ann Medley
Background: Outcome measures typically assess single domains making holistic assessment difficult. Our purpose was to develop a mobility composite measure (MCM) based on four commonly used outcome measures and compare this composite score to the individual measures in patients with neurologic disorders. Methods: We retrospectively reviewed 148 medical records for inclusion of primary neurologic diagnosis and scoring for 5 times sit-to-stand test (5TSST), 10-meter walk test (10MWT), 2-minute walk test (2MWT), and activities-specific balance confidence (ABC) scale...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/29209529/patient-reported-pain-severity-pain-interference-and-health-status-in-hr-her2-advanced-metastatic-breast-cancer
#3
Robert Wood, Debanjali Mitra, Jonathan de Courcy, Shrividya Iyer
Introduction: Patient-reported pain severity and related impact in advanced/metastatic breast cancer (ABC/MBC) are not well documented. The objective of this study was to assess pain and general health status in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) ABC/MBC. Methods: Data were collected in the USA and Europe in a real-world, cross-sectional study. Patients were recruited at oncology practices and completed validated questionnaires; pain severity and interference were assessed using the Brief Pain Inventory (BPI) and general health status using the EuroQoL-5D (EQ-5D-3L)...
2017: ESMO Open
https://www.readbyqxmd.com/read/29185052/functional-status-mediates-the-association-between-peripheral-neuropathy-and-health-related-quality-of-life-in-individuals-with-diabetes
#4
Tessa Riandini, Hwee Lin Wee, Eric Y H Khoo, Bee Choo Tai, Wilson Wang, Gerald C H Koh, E Shyong Tai, Subramaniam Tavintharan, Kurumbian Chandran, Siew Wai Hwang, Kavita Venkataraman
AIMS: To examine differences in health-related quality of life (HRQoL) between patients with and without diabetic peripheral neuropathy (DPN), and whether these differences can be explained by functional deficits. METHODS: This was a cross-sectional study of 160 patients with type 2 diabetes mellitus, 80 with DPN and 80 without. Assessments included HRQoL (health utility score derived from EQ-5D-5L), functional status measurements [muscle strength, timed up and go (TUG), five times sit-to-stand (FTSTS), functional reach, body sway velocity] and self-reported balance confidence [Activities-specific Balance Confidence (ABC) scale]...
November 28, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29174503/external-validation-of-the-arterial-based-complexity-score-and-first-head-to-head-comparison-with-the-r-e-n-a-l-and-padua-scores-and-c-index
#5
Alessandro Antonelli, Alessandro Veccia, Marco Sandri, Maria Chiara Furlan, Stefano Recenti, Mario Sodano, Carlotta Palumbo, Alberto Cozzoli, Claudio Simeone
INTRODUCTION: We performed an external validation of the arterial-based complexity (ABC) score using a head-to-head comparison with the R.E.N.A.L. (radius, exophytic/endophytic tumor properties, nearness of tumor to deepest portion of collecting system or sinus, anterior/posterior descriptor, location relative to the polar line), PADUA (preoperative aspects and dimension for anatomic classification of renal tumors), and C-index scores for the prediction of surgical outcomes after partial nephrectomy...
November 7, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29169576/sarcopenia-and-sarcopenic-obesity-in-spanish-community-dwelling-middle-aged-and-older-women-association-with-balance-confidence-fear-of-falling-and-fall-risk
#6
Agustín Aibar-Almazán, Antonio Martínez-Amat, David Cruz-Díaz, José D Jiménez-García, Alexander Achalandabaso, Indalecio Sánchez-Montesinos, Manuel de la Torre-Cruz, Fidel Hita-Contreras
OBJECTIVES: To analyze the association of sarcopenia, obesity, and sarcopenic obesity (SO) with fear of falling (FoF) and balance confidence in a Spanish sample of middle-aged and older community-dwelling women. STUDY DESIGN AND OUTCOME MEASURES: A total of 235 women (69.21±7.56 years) participated in this study. Body composition (bioelectrical impedance analysis), hand-grip strength, and physical performance (gait speed) were evaluated for the diagnosis of sarcopenia, obesity, and SO...
January 2018: Maturitas
https://www.readbyqxmd.com/read/29159418/reliability-and-convergent-validity-of-the-five-step-test-in-people-with-chronic-stroke
#7
Shamay S M Ng, Mimi M Y Tse, Eric W C Tam, Cynthia Y Y Lai
OBJECTIVES: (i) To estimate the intra-rater, inter-rater and test-retest reliabilities of the Five-Step Test (FST), as well as the minimum detectable change in FST completion times in people with stroke. (ii) To estimate the convergent validity of the FST with other measures of stroke-specific impairments. (iii) To identify the best cut-off times for distinguishing FST performance in people with stroke from that of healthy older adults. DESIGN: A cross-sectional study...
November 17, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29136146/the-abc-death-risk-score-is-it-time-to-start-measuring-gdf-15
#8
M Benjamin Shoemaker, William G Stevenson
No abstract text is available yet for this article.
November 10, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29111114/motor-dysfunction-in-nf1-mediated-by-attention-deficit-or-inherent-to-the-disorder
#9
Karin Haas-Lude, Magdalena Heimgärtner, Sarah Winter, Victor-Felix Mautner, Ingeborg Krägeloh-Mann, Karen Lidzba
AIM: Attention deficit and compromised motor skills are both prevalent in Neurofibromatosis type 1 (NF1), but the relationship is unclear. We investigated motor function in children with NF1 and in children with Attention Deficit/Hyperactivity Disorder (ADHD), and explored if, in patients with NF1, attention deficit influences motor performance. METHODS: Motor performance was measured using the Movement Assessment Battery for Children (M-ABC) in 71 children (26 with NF1 plus ADHD, 14 with NF1 without ADHD, and 31 with ADHD without NF1) aged 6-12 years...
October 20, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29110614/the-correlations-between-postmortem-brain-pathologies-and-cognitive-dysfunction-in-aging-and-alzheimer-s-disease
#10
Wen-Ying Qiu, Qian Yang, Wanying Zhang, Naili Wang, Di Zhang, Yue Huang, Chao Ma
Background The pathological diagnostic criteria for Alzheimer's disease (AD) updated by National Institute on Aging-Alzheimer's Association (NIA-AA) in 2012 has been widely adopted, but the clinicopathological relevance remained obscure in Chinese population. Objective This study aims to investigate the correlations between the antemortem clinical cognitive performances and the postmortem neuropathological changes in the aging and AD brains collected in a human brain bank in China. Method A total of 52 human brains with antemortem cognitive status information [Everyday Cognition (ECog)] were collected through the willed donation program by CAMS/PUMC Human Brain Bank...
November 6, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29104784/external-validation-of-four-nephrometry-scores-for-trans-peritoneal-robotic-partial-nephrectomy
#11
Bhavan Prasad Rai, Amit Patel, Ahmed Abroaf, Narin Suleyman, Shanmugasundaram Gowriemohan, Venkat Prasad, Nikhil Vasdev, Jim Adshead
Introduction: External validation of four nephrometry scores (NS): Centrality index (C-index), arterial based complexity (ABC), preoperative aspects and dimensions used for an anatomical (PADUA) and radius expohytic/endophytic nearness anterior/posterior location (RENAL) scoring systems in patients who have undergone trans-peritoneal robotic assisted partial nephrectomy (RAPN). Material and methods: A prospective database for RAPN has been maintained. Individual NSs were performed on 3-dimensional reconstructions of MDCT/MRI studies retrospectively by a board certified uroradiologist...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/29102438/prediction-of-falls-in-subjects-suffering-from-parkinson-s-disease-multiple-sclerosis-and-stroke
#12
Ettore Beghi, Elisa Gervasoni, Elisabetta Pupillo, Elisa Bianchi, Angelo Montesano, Irene Aprile, Michela Agostini, Marco Rovaris, Davide Cattaneo
OBJECTIVE: To compare the risk of falls and fall predictors in patients with Parkinson's disease (PD), multiple sclerosis (MS) and stroke using the same study design. DESIGN: Multicenter prospective cohort study. SETTING: Three [masked] institutions for physical therapy and rehabilitation. PARTICIPANTS: Patients with PD, MS and stroke seen for rehabilitation. MAIN OUTCOME MEASURES: Functional scales were applied to investigate balance, disability, daily performance, self-confidence with balance, and social integration...
November 1, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29094536/undertaking-an-accurate-and-comprehensive-assessment-of-the-acutely-ill-adult
#13
Paula Mayo
Accurate assessment of the acutely ill adult who has recently been admitted to hospital, or an inpatient whose condition begins to deteriorate, is becoming a required skill for nurses as people live longer and with a variety of complex conditions, and as nursing skills continue to evolve and develop. This article emphasises the importance of undertaking an accurate and comprehensive patient assessment to ensure that management strategies are implemented in a timely manner. The article also considers the importance of the National Early Warning Score (NEWS), which is a 'track-and-trigger' tool designed to identify patients who are at risk of deterioration...
October 18, 2017: Nursing Standard
https://www.readbyqxmd.com/read/29082518/bisphosphonates-and-other-bone-agents-for-breast-cancer
#14
REVIEW
Brent O'Carrigan, Matthew Hf Wong, Melina L Willson, Martin R Stockler, Nick Pavlakis, Annabel Goodwin
BACKGROUND: Bone is the most common site of metastatic disease associated with breast cancer (BC). Bisphosphonates inhibit osteoclast-mediated bone resorption, and novel targeted therapies such as denosumab inhibit other key bone metabolism pathways. We have studied these agents in both early breast cancer and advanced breast cancer settings. This is an update of the review originally published in 2002 and subsequently updated in 2005 and 2012. OBJECTIVES: To assess the effects of bisphosphonates and other bone agents in addition to anti-cancer treatment: (i) in women with early breast cancer (EBC); (ii) in women with advanced breast cancer without bone metastases (ABC); and (iii) in women with metastatic breast cancer and bone metastases (BCBM)...
October 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29071983/-a-preliminary-study-on-effect-of-transcutaneous-electrical-acupoint-stimulation-for-children-with-autism
#15
Ji-Shui Zhang, Xiu-Ting Zhang, Li-Ping Zou, Rong Zhang, Song-Ping Han, Ji-Sheng Han
OBJECTIVE: To investigate the clinical efficacy of transcutaneous electrical acupoint stimulation (TEAS) in treating children with autism spectrum disorders. METHODS: Forty-one autistic children receiving rehabilitation training were randomized into TEAS (n=21) and control (n=20) groups. The control group only received rehabilitation training. The TEAS group received both rehabilitation training and TEAS treatment[2 Hz/15 Hz alternating frequencies through two pairs of skin electrodes placed at Hegu (LI 4)-Neiguan (PC 6) on unilateral side, and Zusanli (ST 36)-Sanyinjiao (SP 6) on the contralateral side]...
June 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29069889/characterizing-helicobacter-pylori-caga-in-myanmar
#16
Thein Myint, Muhammad Miftahussurur, Ratha-Korn Vilaichone, New Ni, Than Than Aye, Phawinee Subsomwong, Tomohisa Uchida, Varocha Mahachai, Yoshio Yamaoka
Background/Aims: Differences in the Helicobacter pylori infection rate are not sufficient to clarify the dissimilarity of gastric cancer incidence between Myanmar and its neighboring countries. To better understand this trend, the H. pylori virulence gene cagA was characterized in Myanmar. Methods: Glutamate-Proline-Isoleucine-Tyrosine-Alanine (EPIYA) patterns and CagA multimerization (CM) motifs of cagA genotypes were examined by performing polymerase chain reactions and DNA sequencing...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29069359/a-biomarker-based-risk-score-to-predict-death-in-patients-with-atrial-fibrillation-the-abc-age-biomarkers-clinical-history-death-risk-score
#17
Ziad Hijazi, Jonas Oldgren, Johan Lindbäck, John H Alexander, Stuart J Connolly, John W Eikelboom, Michael D Ezekowitz, Claes Held, Elaine M Hylek, Renato D Lopes, Salim Yusuf, Christopher B Granger, Agneta Siegbahn, Lars Wallentin
Aims: In atrial fibrillation (AF), mortality remains high despite effective anticoagulation. A model predicting the risk of death in these patients is currently not available. We developed and validated a risk score for death in anticoagulated patients with AF including both clinical information and biomarkers. Methods and results: The new risk score was developed and internally validated in 14 611 patients with AF randomized to apixaban vs. warfarin for a median of 1...
October 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29066999/validation-of-the-italian-version-of-the-dizziness-handicap-inventory-the-situational-vertigo-questionnaire-and-the-activity-specific-balance-confidence-scale-for-peripheral-and-central-vestibular-symptoms
#18
Silvia Colnaghi, Cristiana Rezzani, Marco Gnesi, Marco Manfrin, Silvia Quaglieri, Daniele Nuti, Marco Mandalà, Maria Cristina Monti, Maurizio Versino
Neurophysiological measurements of the vestibular function for diagnosis and follow-up evaluations provide an objective assessment, which, unfortunately, does not necessarily correlate with the patients' self-feeling. The literature provides many questionnaires to assess the outcome of rehabilitation programs for disequilibrium, but only for the Dizziness Handicap Inventory (DHI) is an Italian translation available, validated on a small group of patients suffering from a peripheral acute vertigo. We translated and validated the reliability and validity of the DHI, the Situational Vertigo Questionnaire (SVQ), and the Activities-Specific Balance Confidence Scale (ABC) in 316 Italian patients complaining of dizziness due either to a peripheral or to a central vestibular deficit, or in whom vestibular signs were undetectable by means of instrumental testing or clinical evaluation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29063960/neurodevelopmental-outcome-in-survivors-of-hypoxic-ischemic-encephalopathy-without-cerebral-palsy
#19
Breda C Hayes, Elaine Doherty, Andrea Grehan, Cathy Madigan, Cliona McGarvey, Siobhan Mulvany, Tom G Matthews, Mary D King
To access outcome following hypoxic ischemic encephalopathy (HIE), survivors without cerebral palsy were invited for formal developmental assessment. Children aged ≥ 42 months were assessed using the NEPSY-2, Movement Assessment Battery for Children 2 (Movement ABC-2), Behavior Rating Inventory of Executive Function, and the Child Behavior Checklist. Children aged < 42 months were assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (BSITD-3). One hundred forty-six children attended for assessments [Grade 1 (112), Grade 2 (33), and Grade 3 (1)]...
October 24, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29045002/sufficient-vitamin-k-status-combined-with-sufficient-vitamin-d-status-is-associated-with-better-lower-extremity-function-a-prospective-analysis-of-two-knee-osteoarthritis-cohorts
#20
M Kyla Shea, Richard F Loeser, Timothy E McAlindon, Denise K Houston, Stephen B Kritchevsky, Sarah L Booth
OBJECTIVE: Vitamins K and D are important for the function of vitamin K-dependent proteins in joint tissues. It is unclear if these nutrients are mutually important to functional outcomes related to knee osteoarthritis (OA). We evaluated the association of vitamin K and D sufficiency with lower-extremity function in the Health, Aging Body Composition Knee OA Sub-study (Health ABC) and conducted a replication analysis in an independent cohort, the Osteoarthritis Initiative (OAI). METHODS: In Health ABC (60% female, 75±3 years) baseline nutrient status was measured using circulating vitamin K and 25(OH)D...
October 17, 2017: Arthritis Care & Research
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