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https://www.readbyqxmd.com/read/28645934/repeated-measurements-of-cardiac-biomarkers-in-atrial-fibrillation-and-validation-of-the-abc-stroke-score-over-time
#1
Ziad Hijazi, Bertil Lindahl, Jonas Oldgren, Ulrika Andersson, Johan Lindbäck, Christopher B Granger, John H Alexander, Bernard J Gersh, Michael Hanna, Veli-Pekka Harjola, Elaine M Hylek, Renato D Lopes, Agneta Siegbahn, Lars Wallentin
BACKGROUND: Cardiac biomarkers are independent risk markers in atrial fibrillation, and the novel biomarker-based ABC stroke score (age, biomarkers, and clinical history of prior stroke) was recently shown to improve the prediction of stroke risk in patients with atrial fibrillation. Our aim was to investigate the short-term variability of the cardiac biomarkers and evaluate whether the ABC stroke risk score provides a stable short-term risk estimate. METHODS AND RESULTS: According to the study protocol, samples were obtained at entry and also at 2 months in 4796 patients with atrial fibrillation followed for a median of 1...
June 23, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28633057/predicting-falls-in-community-dwelling-older-adults-using-the-activities-specific-balance-confidence-scale
#2
Kimberly Cleary, Elena Skornyakov
OBJECTIVES: Falls are a significant problem associated with aging, and can lead to serious consequences including injury and death. The purpose of this study was to determine whether balance confidence differed between future fallers and non-fallers, and whether the construct prospectively predicted falls. METHODS: Forty-five community dwelling older adults aged 65 or older completed the Activities-specific Balance Confidence scale (ABC) and reported falls experienced during the next 6 months...
June 13, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28617371/-cognitive-dysfunction-and-content-of-inflammatory-markers-in-patients-after-coronary-artery-bypass-graft
#3
D A Ovchinnikov, D D Amosov, E A Vorobyov, V V Garnyuk, P P Beltiukov, V K Grebennik, M L Gordeev, E R Barantsevich
AIM: To study the relationship between the content of inflammatory biomarkers and cognitive function in patients after coronary artery bypass graft (CABG) performed in condition of artificial blood circulation (ABC) or open-heart surgery (OHS). MATERIAL AND METHODS: Twenty-nine patients with ischemic heart disease who survived CABG, mean age 62.4±6.2 years, were studied. The ABC group (n=18) and OHS group (n=11) were matched for age and sex. Patients underwent standard clinical examination as well as neurological examination and neuropsychological testing...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28616094/arbaclofen-in-fragile-x-syndrome-results-of-phase-3-trials
#4
Elizabeth Berry-Kravis, Randi Hagerman, Jeannie Visootsak, Dejan Budimirovic, Walter E Kaufmann, Maryann Cherubini, Peter Zarevics, Karen Walton-Bowen, Paul Wang, Mark F Bear, Randall L Carpenter
BACKGROUND: Arbaclofen improved multiple abnormal phenotypes in animal models of fragile X syndrome (FXS) and showed promising results in a phase 2 clinical study. The objective of the study is to determine safety and efficacy of arbaclofen for social avoidance in FXS. METHODS: Two phase 3 placebo-controlled trials were conducted, a flexible dose trial in subjects age 12-50 (209FX301, adolescent/adult study) and a fixed dose trial in subjects age 5-11 (209FX302, child study)...
2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28606131/improving-primary-health-care-facility-performance-in-ghana-efficiency-analysis-and-fiscal-space-implications
#5
Jacob Novignon, Justice Nonvignon
BACKGROUND: Health centers in Ghana play an important role in health care delivery especially in deprived communities. They usually serve as the first line of service and meet basic health care needs. Unfortunately, these facilities are faced with inadequate resources. While health policy makers seek to increase resources committed to primary healthcare, it is important to understand the nature of inefficiencies that exist in these facilities. Therefore, the objectives of this study are threefold; (i) estimate efficiency among primary health facilities (health centers), (ii) examine the potential fiscal space from improved efficiency and (iii) investigate the efficiency disparities in public and private facilities...
June 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28603356/effects-of-phase-proprioceptive-training-on-balance-in-patients-with-chronic-stroke
#6
Seung Hun Chae, You Lim Kim, Suk Min Lee
[Purpose] This study aimed to investigate the effect of phase proprioceptive training on balance in patients with chronic stroke. [Subjects and Methods] Participants included 30 patients with stroke who were randomly assigned to the proprioceptive training group (n=15) or control group (n=15). Participants in the proprioceptive training group underwent proprioceptive training and received general physical therapy each for a total of 20 thirty-minute sessions, five times per week, during a period of four weeks; the control group received general physical therapy for a total of 20 sixty-minute sessions, five times per week, during a period of four weeks...
May 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28582463/drug-resistance-testing-through-remote-genotyping-and-predicted-treatment-options-in-human-immunodeficiency-virus-type-1-infected-tanzanian-subjects-failing-first-or-second-line-antiretroviral-therapy
#7
Jenny Svärd, Sabina Mugusi, Doreen Mloka, Ujjwal Neogi, Genny Meini, Ferdinand Mugusi, Francesca Incardona, Maurizio Zazzi, Anders Sönnerborg
INTRODUCTION: Antiretroviral therapy (ART) has been successfully introduced in low-middle income countries. However an increasing rate of ART failure with resistant virus is reported. We therefore described the pattern of drug resistance mutations at antiretroviral treatment (ART) failure in a real-life Tanzanian setting using the remote genotyping procedure and thereafter predicted future treatment options using rule-based algorithm and the EuResist bioinformatics predictive engine. According to national guidelines, the default first-line regimen is tenofovir + lamivudine + efavirenz, but variations including nevirapine, stavudine or emtricitabine can be considered...
2017: PloS One
https://www.readbyqxmd.com/read/28574916/functional-performance-and-balance-in-the-oldest-old
#8
Michal Kafri, Yeshayahu Hutzler, Olga Korsensky, Yocheved Laufer
BACKGROUND AND PURPOSE: The group of individuals 85 years and over (termed oldest-old) is the fastest-growing population in the Western world. Although daily functional abilities and balance capabilities are known to decrease as an individual grows older, little is known about the balance and functional characteristics of the oldest-old population. The aims of this study were to characterize balance control, functional abilities, and balance self-efficacy in the oldest-old, to test the correlations between these constructs, and to explore differences between fallers and nonfallers in this age group...
June 1, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28570925/exploring-factors-influencing-hba1c-and-psychosocial-outcomes-in-people-with-type-1-diabetes-after-training-in-advanced-carbohydrate-counting
#9
Signe Schmidt, Dorte Vistisen, Thomas Almdal, Eva Hommel, Kirsten Nørgaard
AIMS: The purpose of this secondary analysis of the StenoABC Study was to identify determinants of the changes in HbA1c observed after training of people with type 1 diabetes in advanced carbohydrate counting (ACC) and automated bolus calculator (ABC) use, and further to investigate psychosocial effects of these insulin dosing approaches. METHODS: Validated diabetes-specific questionnaires were used to assess diabetes treatment satisfaction, problem areas in diabetes, fear of hypoglycemia and diabetes dependent quality of life before and one year after the training...
May 19, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28570752/external-validation-of-the-arterial-based-complexity-abc-scoring-system-in-renal-tumors-treated-by-minimally-invasive-partial-nephrectomy
#10
Liangyou Gu, Xin Ma, Hongzhao Li, Yuanxin Yao, Yongpeng Xie, Luyao Chen, Yu Gao, Xu Zhang
OBJECTIVE: To assess the role of the Arterial Based Complexity (ABC) scoring system in predicting clinically relevant outcomes of a minimally invasive partial nephrectomy (MIPN). PATIENTS AND METHODS: We retrospectively reviewed 350 consecutive patients who underwent a MIPN between 2013 and 2014. Tumor complexity was evaluated according to the ABC scoring system. Complications, surgical, and renal outcomes were recorded. RESULTS: There were respectively 36 (10...
June 1, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28529667/motor-problems-in-children-with-neurofibromatosis-type-1
#11
André B Rietman, Rianne Oostenbrink, Sanne Bongers, Eddy Gaukema, Sandra van Abeelen, Jos G Hendriksen, Caspar W N Looman, Pieter F A de Nijs, Marie-Claire de Wit
BACKGROUND: Children with the neurogenetic disorder neurofibromatosis type 1 (NF1) often have problems with learning and behaviour. In both parent reports and neuropsychological assessment, motor problems are reported in approximately one third to one half of the children with NF1. Studies using broad motor performance test batteries with relatively large groups of children with NF1 are limited. The aim of this cross-sectional observational study was to describe the severity of motor problems in children with NF1 and to explore the predictive value of demographics, intelligence, and behavioural problems...
2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28498937/the-prevalence-of-anosmia-and-associated-factors-among-u-s-black-and-white-older-adults
#12
Jing Dong, Jayant M Pinto, Xuguang Guo, Alvaro Alonso, Gregory Tranah, Jane A Cauley, Melissa Garcia, Suzanne Satterfield, Xuemei Huang, Tamara Harris, Thomas H Mosley, Honglei Chen
Background: Olfactory impairment is common among older adults; however, data are largely limited to whites. Methods: We conducted pooled analyses of two community-based studies: the Atherosclerosis Risk in Communities study (ARIC, 1,398 blacks and 4,665 whites), and the Health, Aging, and Body Composition study (Health ABC, 958 blacks and 1,536 whites) to determine the prevalence of anosmia and associated factors for black and white older adults in the United States...
May 11, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28484366/serum-oxytocin-levels-and-an-oxytocin-receptor-gene-polymorphism-rs2254298-indicate-social-deficits-in-children-and-adolescents-with-autism-spectrum-disorders
#13
Shuhan Yang, Xiaopeng Dong, Xuan Guo, Yu Han, Hanbing Song, Lei Gao, Wei Dai, Yuanyuan Su, Xin Zhang
The neuropeptide oxytocin (OT) and its receptor (OXTR) have been predicted to be involved in the regulation of social functioning in autism spectrum disorders (ASD). Objective of the study was to investigate serum OT levels and the OXTR rs2254298 polymorphism in Chinese Han children and adolescents with ASD as well as to identify their social deficits relevant to the oxytocinergic system. We tested serum OT levels using ELISA in 55 ASD subjects and 110 typically developing (TD) controls as well as genotyped the OXTR rs2254298 polymorphism using PCR-RFLP in 100 ASD subjects and 232 TD controls...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28463979/gastric-mucosal-status-in-populations-with-a-low-prevalence-of-helicobacter-pylori-in-indonesia
#14
Muhammad Miftahussurur, Iswan Abbas Nusi, Fardah Akil, Ari Fahrial Syam, I Dewa Nyoman Wibawa, Yudith Annisa Ayu Rezkitha, Ummi Maimunah, Phawinee Subsomwong, Muhammad Luthfi Parewangi, I Ketut Mariadi, Pangestu Adi, Tomohisa Uchida, Herry Purbayu, Titong Sugihartono, Langgeng Agung Waskito, Hanik Badriyah Hidayati, Maria Inge Lusida, Yoshio Yamaoka
In Indonesia, endoscopy services are limited and studies about gastric mucosal status by using pepsinogens (PGs) are rare. We measured PG levels, and calculated the best cutoff and predictive values for discriminating gastric mucosal status among ethnic groups in Indonesia. We collected gastric biopsy specimens and sera from 233 patients with dyspepsia living in three Indonesian islands. When ≥5.5 U/mL was used as the best cutoff value of Helicobacter pylori antibody titer, 8.6% (20 of 233) were positive for H...
2017: PloS One
https://www.readbyqxmd.com/read/28452904/a-placebo-controlled-crossover-trial-of-gastrin-releasing-peptide-in-childhood-autism
#15
Josemar Marchezan, Michele Becker, Gilberto Schwartsmann, Lygia Ohlweiler, Rafael Roesler, Luiza Brusius Renck, Marcela Matos Monteiro Gonçalves, Josiane Ranzan, Rudimar Dos Santos Riesgo
OBJECTIVES: The aim of this study was to evaluate the efficacy, safety, and tolerability of gastrin-releasing peptide (GRP) compared with placebo in autism spectrum disorder symptoms. METHODOLOGY: This is a randomized, double-blind, placebo-controlled crossover trial using GRP 160 pmol/kg for 4 consecutive days in 10 children with autism. Outcomes were measured by the Aberrant Behavior Checklist (ABC) scale. RESULTS: All participants were boys, aged between 4 and 9 years...
May 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28452870/every-minute-counts-time-to-delivery-of-initial-massive-transfusion-cooler-and-its-impact-on-mortality
#16
David E Meyer, Laura E Vincent, Erin E Fox, Terence OʼKeeffe, Kenji Inaba, Eileen Bulger, John B Holcomb, Bryan A Cotton
BACKGROUND: American College of Surgeons Trauma Quality Improvement Best Practices recommends initial massive transfusion (MT) cooler delivery within 15 minutes of protocol activation, with a goal of 10 minutes. The current study sought to examine the impact of timing of first cooler delivery on patient outcomes. METHODS: Patients predicted to receive MT at 12 Level I trauma centers were randomized to two separate transfusion ratios as described in the PROPPR trial...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28449004/minimal-detectable-change-for-balance-measurements-in-patients-with-copd
#17
Wajdi Mkacher, Zouhair Tabka, Yassine Trabelsi
PURPOSE: The purpose of this study was to determine the reliability and minimal detectable change (MDC) of various outcome measures that are potentially suitable for evaluating postural control in individuals with chronic obstructive pulmonary disease (COPD). METHODS: This was a test-retest reliability study. Participants with COPD were asked to complete 5 balance assessments, separated by 1 week. The assessments included Timed Up and Go (TUG) Test, Unipodal Stance Test (UST), Tinetti Test, Berg Balance Scale (BBS), and the Activities Balance Confidence (ABC) scale...
May 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28435236/activities-specific-balance-confidence-scale-for-predicting-future-falls-in-indian-older-adults
#18
Jamal Ali Moiz, Vishal Bansal, Majumi M Noohu, Shailendra Nath Gaur, Mohammad Ejaz Hussain, Shahnawaz Anwer, Ahmad Alghadir
BACKGROUND: Activities-specific balance confidence (ABC) scale is a subjective measure of confidence in performing various ambulatory activities without falling or experiencing a sense of unsteadiness. OBJECTIVE: This study aimed to examine the ability of the Hindi version of the ABC scale (ABC-H scale) to discriminate between fallers and non-fallers and to examine its predictive validity for prospective falls. DESIGN: This was a prospective cohort study...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28401876/dolutegravir-abacavir-lamivudine-versus-current-art-in-virally-suppressed-patients-striiving-a-48-week-randomized-non-inferiority-open-label-phase-iiib-study
#19
Benoît Trottier, Jordan E Lake, Ken Logue, Cynthia Brinson, Lizette Santiago, Clare Brennan, Justin A Koteff, Brian Wynne, Judy Hopking, Catherine Granier, Michael Aboud
BACKGROUND: Simplified dosing regimens are important for patients who face challenges in adhering to HIV-1 therapy. We investigated the safety and virologic efficacy of switching to once-daily abacavir/dolutegravir/lamivudine (ABC/DTG/3TC). METHODS: The STRIIVING study was a randomized, open-label, phase IIIb study in adults with HIV-1 RNA <50 copies/mL on antiretroviral therapy (ART) at enrolment (ClinicalTrials.gov identifier, NCT02105987). Subjects were randomly assigned to switch to ABC/DTG/3TC once daily for 48 weeks (early-switch group) or continue current ART for 24 weeks and then switch to ABC/DTG/3TC (late-switch group)...
April 12, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28396041/association-of-holter-derived-heart-rate-variability-parameters-with-the-development-of-congestive-heart-failure-in-the-cardiovascular-health-study
#20
Vaiibhav N Patel, Brian R Pierce, Rohan K Bodapati, David L Brown, Diane G Ives, Phyllis K Stein
OBJECTIVES: This study sought to determine whether Holter-based parameters of heart rate variability (HRV) are independently associated with incident heart failure among older adults in the CHS (Cardiovascular Health Study) as evidenced by an improvement in the predictive power of the Health Aging and Body Composition Heart Failure (Health ABC) score. BACKGROUND: Abnormal HRV, a marker of autonomic dysfunction, has been associated with multiple adverse cardiovascular outcomes but not the development of congestive heart failure (CHF)...
June 2017: JACC. Heart Failure
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