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https://www.readbyqxmd.com/read/29992491/pbmt-and-topical-diclofenac-as-single-and-combined-treatment-on-skeletal-muscle-injury-in-diabetic-rats-effects-on-biochemical-and-functional-aspects
#1
Ligiane Souza Dos Santos, Joyce Camilla Saltorato, Marina Gaiato Monte, Rodrigo Labat Marcos, Rodrigo Álvaro Brandão Lopes-Martins, Shaiane Silva Tomazoni, Ernesto Cesar Pinto Leal-Junior, Rodrigo Leal de Paiva Carvalho
Physical exercise generates several benefits in a short time in patients with diabetes mellitus. However, it can increase the chances of muscle damage, a serious problem for diabetic patients. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat these injuries, despite the serious adverse effects. In this way, photobiomodulation therapy (PBMT) with low-level laser therapy (LLLT) and/or light emitting diode therapy (LEDT) can be used as an alternative in this case. However, its efficacy in tissue repair of trauma injuries in diabetes mellitus until now is unknown, as well as the combination between PBMT and NSAIDs...
July 10, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29991584/acinetobacter-baumannii-gastrointestinal-colonization-is-facilitated-by-secretory-iga-which-is-reductively-dissociated-by-bacterial-thioredoxin-a
#2
Patrick M Ketter, Jieh-Juen Yu, M Neal Guentzel, Holly C May, Rishein Gupta, Mark Eppinger, Karl E Klose, J Seshu, James P Chambers, Andrew P Cap, Bernard P Arulanandam
Multidrug-resistant Acinetobacter baumannii is among the most common causes of infectious complications associated with combat-related trauma in military personnel serving overseas. However, little is currently known about its pathogenesis. While the gastrointestinal (GI) tract has been found to be a major reservoir for A. baumannii , as well as to potentially contribute to development of multidrug resistance, no studies have addressed the mechanisms involved in gut colonization. In this study, we address this critical gap in knowledge by first assessing the interaction between secretory IgA (SIgA), the principal humoral immune defense on mucosal surfaces, and the A...
July 10, 2018: MBio
https://www.readbyqxmd.com/read/29986356/-acute-gout-in-emergency-admissions-patient-characteristics-and-adherence-of-care-processes-to-current-guidelines
#3
Bettina Engel, Sylvia Schacher, Klaus Weckbecker, Annika Stausberg, Ingo Gräff
BACKGROUND: Gout or hyperuricemia are both well known and common diseases. The prevalence of gout is increasing worldwide. Thus, patients with gout are becoming more common. Although there are several published guidelines for the management of gout, actual treatment of gout is inconsistent with these guidelines in many respects. Gout is usually treated by general practitioners (GP) in Germany. The aim of our study was to show which patients present to the emergency department and to record how treatment and clinical diagnostic testing of gout patients is performed in the emergency department of a university hospital in Germany...
July 9, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29985933/combining-h-fabp-and-gfap-increases-the-capacity-to-differentiate-between-ct-positive-and-ct-negative-patients-with-mild-traumatic-brain-injury
#4
Linnéa Lagerstedt, Juan José Egea-Guerrero, Alejandro Bustamante, Ana Rodríguez-Rodríguez, Amir El Rahal, Manuel Quintana-Diaz, Roser García-Armengol, Carmen Melinda Prica, Elisabeth Andereggen, Lara Rinaldi, Asita Sarrafzadeh, Karl Schaller, Joan Montaner, Jean-Charles Sanchez
Mild traumatic brain injury (mTBI) patients may have trauma-induced brain lesions detectable using CT scans. However, most patients will be CT-negative. There is thus a need for an additional tool to detect patients at risk. Single blood biomarkers, such as S100B and GFAP, have been widely studied in mTBI patients, but to date, none seems to perform well enough. In many different diseases, combining several biomarkers into panels has become increasingly interesting for diagnoses and to enhance classification performance...
2018: PloS One
https://www.readbyqxmd.com/read/29985861/resuscitative-strategies-in-the-trauma-patient-the-past-the-present-and-the-future
#5
Brody G Eick, Nancy J Denke
Over the last decade, trends in fluid resuscitation have changed dramatically as have our practices. Research is driving trauma centers across the globe to initiate modifications in fluid resuscitation of the hemorrhagic trauma patients both in the prehospital and intrahospital arena. This is being done by combining the theory of permissive hypotension and damage control surgery with hemostatic resuscitation as the preferred methods of resuscitation in patients with hemorrhagic shock. The literature illustrates that previous strategies we considered to be beneficial are actually detrimental to the outcomes of these severely injured patients...
July 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29983688/functional-reconstruction-of-acutely-burnt-achilles-tendon-with-composite-anterolateral-thigh-flap-with-fascia-lata-a-case-report
#6
V Andreu-Sola, J Aguilera-Sáez, D Rivas-Nicolls, P Bosacoma Roura, J P Barret
Soft tissue defects in the postero-inferior aspect of the leg are still challenging, especially when they affect the Achilles tendon due to its important functional involvement in the normal movement of the ankle. Dorsiflexion and flexion may be affected if proper reconstruction is not achieved, thus limiting daily activities such as walking, climbing stairs or running. Several techniques, including local or regional flaps, combinations of tendon substitutes with free muscular or fasciocutaneous flaps, and free composite flaps with tendon have been described for the reconstruction of complex defects caused by burn sequelae, tumors, trauma, chronic ulcers, etc...
December 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29974393/tibial-pilon-fractures-treated-with-hybrid-external-fixator-analysis-of-75-cases
#7
M Scaglione, F Celli, F Casella, L Fabbri
INTRODUCTION: The treatment of tibial pilon fractures is a surgical challenge due to the particular anatomical and vascular characteristics of this area, and the severity of the injury that can compromise soft tissues. Nowadays there is no gold-standard treatment for these fractures. MATERIALS AND METHODS: We reviewed 75 patients with tibial pilon fracture type C (AO classification) treated with hybrid external fixation (Stryker TenXor® ). The surgical technique was reported...
July 5, 2018: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29972854/-bilateral-proximal-humerus-fracture-a-rare-combination-with-a-high-complication-rate-after-surgery
#8
Matthias Königshausen, Valentin Rausch, Eileen Mempel, Alexander von Glinski, Christopher Ull, Maria Bernstorff, Thomas Schildhauer, Dominik Seybold, Jan Gessmann
INTRODUCTION: Bilateral acute proximal humerus fractures are rare. There are no data available about these bilateral injuries. The aim of the study was to analyse bilateral proximal humerus fractures retrospectively in terms of incidence, complications and revisions. METHODS: All bilateral proximal humerus fractures were evaluated retrospectively using the institution's database, with the focus on cause of the injury, fracture severity and the clinical course compared to published information on monolateral proximal humerus fractures...
July 4, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29969720/combined-median-and-ulnar-nerve-palsy-complicating-distal-radius-fractures
#9
Florence Dauzere, Stéphanie Delclaux, Thi Thuy Trang Pham, Michel Rongières, Pierre Mansat
BACKGROUND: Fractures of the distal radius only rarely give rise to complications in the immediate post-operative period. Combined median and ulnar nerve palsy is a complication that can be missed by the surgeon. MATERIALS AND METHODS: Three cases diagnosed early after surgery are reported here. The patients were 15, 16, and 30 years of age, respectively. None had pre-operative neurological deficits. The youngest patient was injured during sports and the other 2 patients during traffic accidents...
June 30, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29965991/prehospital-ultrasound-guided-nerve-blocks-improve-reduction-feasibility-of-dislocated-extremity-injuries-compared-to-systemic-analgesia-a-randomized-controlled-trial
#10
Benedikt Büttner, Ashham Mansur, Matthias Kalmbach, José Hinz, Thomas Volk, Karoly Szalai, Markus Roessler, Ingo Bergmann
BACKGROUND: Out-of-hospital analgosedation in trauma patients is challenging for emergency physicians due to associated complications. We compared peripheral nerve block (PNB) with analgosedation (AS) as an analgetic approach for patients with isolated extremity injury, assuming that prehospital required medical interventions (e.g. reduction, splinting of dislocation injury) using PNB are less painful and more feasible compared to AS. METHODS: Thirty patients (aged 18 or older) were randomized to receive either ultrasound-guided PNB (10 mL prilocaine 1%, 10 mL ropivacaine 0...
2018: PloS One
https://www.readbyqxmd.com/read/29961154/brachial-plexus-injury-after-shoulder-dislocation-a-literature-review
#11
REVIEW
Olga Gutkowska, Jacek Martynkiewicz, Maciej Urban, Jerzy Gosk
Brachial plexus injuries are among the rarest but at the same time the most severe complications of shoulder dislocation. The symptoms range from transient weakening or tingling sensation of the upper limb to total permanent paralysis of the limb associated with chronic pain and disability. Conflicting opinions exist as to whether these injuries should be treated operatively and if so when surgery should be performed. In this review, available literature dedicated to neurological complications of shoulder dislocation has been analysed and management algorithm has been proposed...
June 30, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29958248/the-combined-utility-of-extended-focused-assessment-with-sonography-for-trauma-and-chest-x-ray-in-blunt-thoracic-trauma
#12
Morgan Schellenberg, Kenji Inaba, James M Bardes, Nicholas Orozco, Jessica Chen, Caroline Park, Tarina Kang, Demetrios Demetriades
BACKGROUND: Portable chest x-ray (CXR) and extended focused assessment with sonography for trauma (EFAST) screen patients for thoracic injury in the trauma bay. It is unclear if one test alone is sufficient, if both are required, or if the two investigations are complementary. Study objectives were to define the combined diagnostic yield of EFAST and CXR among stable blunt thoracic trauma patients and to determine if a normal EFAST and CXR might obviate the need for computed tomography (CT) scan of the chest...
July 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29941768/optic-nerve-avulsion-associated-with-central-retinal-artery-occlusion-following-rotational-globe-injury
#13
Isha Lohmror, Maya Hada, Vishal Agarwal, Kamlesh Khilnani
Avulsion of the optic nerve head is a rare and severe complication of ocular blunt trauma. Herein, we describe a case of 16-year-old boy, who presented with a rare combination of optic nerve avulsion associated with central retinal artery occlusion, following blunt trauma with a leather ball. This report highlights the potential blinding complication following rotational injury.
July 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29938790/automated-monitoring-compared-to-standard-care-for-the-early-detection-of-sepsis-in-critically-ill-patients
#14
REVIEW
Sheryl Warttig, Phil Alderson, David Jw Evans, Sharon R Lewis, Irene S Kourbeti, Andrew F Smith
BACKGROUND: Sepsis is a life-threatening condition that is usually diagnosed when a patient has a suspected or documented infection, and meets two or more criteria for systemic inflammatory response syndrome (SIRS). The incidence of sepsis is higher among people admitted to critical care settings such as the intensive care unit (ICU) than among people in other settings. If left untreated sepsis can quickly worsen; severe sepsis has a mortality rate of 40% or higher, depending on definition...
June 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29931268/placenta-to-the-rescue-limb-salvage-using-dehydrated-human-amnion-chorion-membrane
#15
Victoria Schlanser, Andrew Dennis, Katarina Ivkovic, Kimberly Joseph, Matthew Kaminsky, Thomas Messer, Stathis Poulakidas, Frederic Starr, Faran Bokhari
Reconstruction of skin and soft tissue wounds can pose a unique surgical challenge. This is especially true for cases of exposed bone and tendon where soft tissue loss is extensive and opportunities for tissue advancement or rotation are limited. A clinical case is presented describing an experience with dehydrated human amnion/chorion membrane (dHACM, EpiFix®/AmnioFix®, MiMedx Group, Marietta, GA) graft to obtain granulation over an open fracture with desiccated bone. The 22-year-old female trauma patient presented with high-grade bilateral lower extremity soft tissue loss after being run over and dragged by a semitruck...
December 5, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29927788/the-mitochondria-targeted-h2s-donor-ap39-in-a-murine-model-of-combined-hemorrhagic-shock-and-blunt-chest-trauma
#16
Martin Wepler, Tamara Merz, Ulrich Wachter, Josef Vogt, Enrico Calzia, Angelika Scheuerle, Peter Möller, Michael Gröger, Sandra Kress, Marina Fink, Britta Lukaschewski, Grégoire Rumm, Bettina Stahl, Michael Georgieff, Markus Huber-Lang, Roberta Torregrossa, Matthew Whiteman, Oscar McCook, Peter Radermacher, Clair Hartmann
Hemorrhagic shock (HS) accounts for 30-40% of trauma-induced mortality, which is due to multi-organ-failure subsequent to systemic hyper-inflammation, triggered by hypoxemia and tissue ischemia. The slow-releasing, mitochondria-targeted H2S donor AP39 exerted beneficial effects in several models of I/R-injury and acute inflammation. Therefore, we tested the effects of AP39-treatment in a murine model of combined blunt chest trauma (TxT) and HS with subsequent resuscitation. METHODS: After blast wave-induced TxT or sham procedure, anesthetized and instrumented mice underwent 1 hour of hemorrhage followed by 4 hours of resuscitation comprising an i...
June 20, 2018: Shock
https://www.readbyqxmd.com/read/29926943/periodontal-manifestations-of-systemic-diseases-and-developmental-and-acquired-conditions-consensus-report-of-workgroup-3-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#17
Søren Jepsen, Jack G Caton, Jasim M Albandar, Nabil F Bissada, Philippe Bouchard, Pierpaolo Cortellini, Korkud Demirel, Massimo de Sanctis, Carlo Ercoli, Jingyuan Fan, Nicolaas C Geurs, Francis J Hughes, Lijian Jin, Alpdogan Kantarci, Evanthia Lalla, Phoebus N Madianos, Debora Matthews, Michael K McGuire, Michael P Mills, Philip M Preshaw, Mark A Reynolds, Anton Sculean, Cristiano Susin, Nicola X West, Kazuhisa Yamazaki
BACKGROUND: A variety of systemic diseases and conditions can affect the course of periodontitis or have a negative impact on the periodontal attachment apparatus. Gingival recessions are highly prevalent and often associated with hypersensitivity, the development of caries and non-carious cervical lesions on the exposed root surface and impaired esthetics. Occlusal forces can result in injury of teeth and periodontal attachment apparatus. Several developmental or acquired conditions associated with teeth or prostheses may predispose to diseases of the periodontium...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926500/periodontal-manifestations-of-systemic-diseases-and-developmental-and-acquired-conditions-consensus-report-of-workgroup-3-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#18
Søren Jepsen, Jack G Caton, Jasim M Albandar, Nabil F Bissada, Philippe Bouchard, Pierpaolo Cortellini, Korkud Demirel, Massimo de Sanctis, Carlo Ercoli, Jingyuan Fan, Nicolaas C Geurs, Francis J Hughes, Lijian Jin, Alpdogan Kantarci, Evanthia Lalla, Phoebus N Madianos, Debora Matthews, Michael K McGuire, Michael P Mills, Philip M Preshaw, Mark A Reynolds, Anton Sculean, Cristiano Susin, Nicola X West, Kazuhisa Yamazaki
BACKGROUND: A variety of systemic diseases and conditions can affect the course of periodontitis or have a negative impact on the periodontal attachment apparatus. Gingival recessions are highly prevalent and often associated with hypersensitivity, the development of caries and non-carious cervical lesions on the exposed root surface and impaired esthetics. Occlusal forces can result in injury of teeth and periodontal attachment apparatus. Several developmental or acquired conditions associated with teeth or prostheses may predispose to diseases of the periodontium...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29922458/neuroarthropathy-in-diabetes-pathogenesis-of-charcot-arthropathy
#19
S E Johnson-Lynn, A W McCaskie, A P Coll, A H N Robinson
Charcot neuroarthropathy is a rare but serious complication of diabetes, causing progressive destruction of the bones and joints of the foot leading to deformity, altered biomechanics and an increased risk of ulceration. Management is complicated by a lack of consensus on diagnostic criteria and an incomplete understanding of the pathogenesis. In this review, we consider recent insights into the development of Charcot neuroarthropathy. It is likely to be dependent on several interrelated factors which may include a genetic pre-disposition in combination with diabetic neuropathy...
May 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29912812/multicenter-review-of-current-practices-associated-with-venous-thromboembolism-prophylaxis-in-pediatric-patients-after-trauma
#20
Amee M Bigelow, Katherine T Flynn-O'Brien, Pippa M Simpson, Mahua Dasgupta, Sheila J Hanson
OBJECTIVES: Frequency of venous thromboembolism in pediatric trauma patients admitted to PICUs is not insignificant, ranging up to 6%. Risk factors have been identified in this population. However, there is little consensus of actual venous thromboembolism prophylaxis practice. We examined factors associated with venous thromboembolism prophylaxis in PICUs. DESIGN: A retrospective study evaluating associations with mechanical venous thromboembolism prophylaxis, pharmacologic venous thromboembolism prophylaxis, or dual therapy (DUAL) prophylaxis compared with no venous thromboembolism prophylaxis...
June 15, 2018: Pediatric Critical Care Medicine
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