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severe combined trauma

Mingxia Tian
RATIONALE: Surgically lifting and scraping, mitomycin C, fibrin glue, Nd:YAG laser, hydrogel ocular sealant, and amniotic membrane patch are the reported methods for treating epithelial ingrowth after laser in situ keratomileusis (LASIK). Here we report the management of a rare case of recalcitrant epithelial ingrowth using a combined scraping/laser ablation that occurred after LASIK. PATIENT CONCERNS: A female patient underwent uncomplicated bilateral LASIK 10 years before incurring trauma to the right eye...
October 2018: Medicine (Baltimore)
Keith M Porter, Anthony D Dayan, Sara Dickerson, Paul M Middleton
Methoxyflurane is an inhaled analgesic administered via a disposable inhaler which has been used in Australia for over 40 years for the management of pain associated with trauma and for medical procedures in children and adults. Now available in 16 countries worldwide, it is licensed in Europe for moderate to severe pain associated with trauma in conscious adults, although additional applications are being made to widen the range of approved indications. Considering these ongoing developments, we reviewed the available evidence on clinical usage and safety of inhaled analgesic methoxyflurane in trauma pain and in medical procedures in both adults and children...
2018: Open Access Emergency Medicine: OAEM
Y-X Zhang, L-P Liu, M Li, J-L Huang, H Xu, X-D Chen, W-Y Zhu, Y-P Cai, N-N Guo, Z-Q Chen, Y-W Zheng, Y-M Li
OBJECTIVE: Presently, interesting research related to induced pluripotent stem cells (iPSCs) is emerging. However, the development of new therapies and techniques for treatment of refractory diseases is still required in dermatology. We are exploring novel methods to provide stem cell therapy and elucidate research mechanisms underlying troublesome diseases by reprogramming iPSCs from the fibroblasts of keloid lesions from patients in vitro. METHOD: Here, we identified the expression of fibroblastic genes in the fibroblast derived from diseased individuals...
November 2018: Transplantation Proceedings
Georgia Tsaousi, George Stavrou, Kyriakos Fotiadis, Katerina Kotzampassi, George Kolios
Adhesions formation is considered a significant clinical entity implicating the healing process following major abdominal surgery, with serious clinical consequences and need for substantial health care expenditures. Several agents and substances applied either locally or systematically could potentially function as inhibitors of the formation of peritoneal adhesions endowed by limiting tissue apposition during the critical stages of mesothelial repair. Phospholipids are identified as surfactant-like substances, acting as a temporary membrane-like coverage of serosal defects...
November 1, 2018: European Journal of Pharmacology
José Antonio Sainz, José Antonio García-Mejido, Adriana Aquise, Carlota Borrero, María José Bonomi, Ana Fernández-Palacín
BACKGROUND: Complicated operative vaginal deliveries are associated with high neonatal morbidity and maternal trauma, especially if the procedure is unsuccessful and a cesarean delivery is needed. The decision to perform an operative vaginal delivery has traditionally been based on a subjective assessment by digital vaginal examination combined with the clinical expertise of the obstetrician. Currently, there is no method for objectively quantifying the likelihood of successful delivery...
October 31, 2018: American Journal of Obstetrics and Gynecology
Maria Rotaru, Sanda Marchian, Gyula Laszlo Fekete, Gabriela Mariana Mariana Iancu
Dear Editor, Eczema is an inflammatory dermatitis mediated by cellular immunity, with an etiology in which environmental, immunological, and genetic factors are involved. Skin inflammation through proinflammatory cytokines creates a favorable environment for microbial antigens and optimal conditions for infection (1). In case of underlying immunosuppression, inflammatory features of dermatitis and superimposed infections are more severe. The presence of minor trauma of the skin in the form of fissures can favor both easier inoculation of some bacterial germs, leading to a dermatitis superinfection, and/or the transcutaneous inoculation of atypical mycobacteria, with a possibility of developing localized types of tuberculous lymphadenitis (TLA)...
October 2018: Acta Dermatovenerologica Croatica: ADC
L E Bolton, C Bainbridge
PURPOSE: Pyogenic flexor tenosynovitis (PFT) is recognized as a severe infection of the hand with potentially disastrous outcomes. The mainstay of treatment has been emergent surgical washout. Recent evidence suggests potential for conservative management with a combination of intravenous antibiotics, elevation and splinting. We aim to determine current management of PFT to guide further education and research. METHOD: An electronic survey was distributed to attendees at the Pulvertaft Hand Trauma Symposium in May 2017...
November 1, 2018: Infection
Johanna Schröder, Susanne Nick, Hertha Richter-Appelt, Peer Briken
Organized and ritual child sexual abuse (ORA) is often rooted in the child's own family. Empirical evidence on possible associations between ORA and trauma-related symptoms in those who report this kind of extreme and prolonged violence is rare. The aim of our study was to explore socio-demographic and clinical characteristics of the individuals reporting ORA experiences, and to investigate protective as well as promotive factors in the link between ORA and trauma-related symptom severity. Within the framework of a project of the Independent Inquiry into Child Sexual Abuse in Germany, we recruited 165 adults who identified themselves as ORA victims via abuse- and trauma-specific networks and mailing lists, and they completed an anonymous online survey...
October 31, 2018: International Journal of Environmental Research and Public Health
Fernando A Fierro, Nataly Magner, Julie Beegle, Heather Dahlenburg, Jeannine Logan White, Ping Zhou, Karen Pepper, Brian Fury, Dane Philip Coleal-Bergum, Gerhard Bauer, William Gruenloh, Geralyn Annett, Christy Pifer, Jan A Nolta
Mesenchymal stem/stromal cells (MSCs) may be able to improve ischemic conditions as they can actively seek out areas of low oxygen and secrete proangiogenic factors. In more severe trauma and chronic cases, however, cells alone may not be enough. Therefore, we have combined the stem cell and angiogenic factor approaches to make a more potent therapy. We developed an engineered stem cell therapy product designed to treat critical limb ischemia that could also be used in trauma-induced scarring and fibrosis where additional collateral blood flow is needed following damage to and blockage of the primary vessels...
November 1, 2018: Transfusion
Eo Jin Kim, Joonghyun Ahn, Seung-Ju Kim
BACKGROUND: Spontaneous spinal epidural hematoma (SSEH) is an uncommon disease, but it can lead to acute cord compression with disabling consequences. Identifiable reasons for spontaneous hemorrhage are vascular malformations and bleeding disorders. However, SSEH after taking herbal medicines has not been described yet. CASE PRESENTATION: A 60-year-old female experienced sudden back pain combined with numbness and weakness in the lower limbs for several hours with no trauma, drug use, family history or any disease history...
October 29, 2018: BMC Complementary and Alternative Medicine
Conall O'Rourke, Mark A Linden, Maria Lohan
OBJECTIVE: To examine the prevalence of traumatic brain injury (TBI) and past abuse experienced by adult female offenders. METHODS: Twenty-nine female offenders from a UK women's prison and twenty-nine age and gender matched university controls were recruited. In addition to demographic data, the Brain Injury Screening Index was utilized alongside the Childhood Trauma Questionnaire and the Abusive Behaviour Inventory. RESULTS: Approximately 79% (n = 21) of female offenders reported a history of TBI, with 38% (n = 8) reporting six or more injuries...
October 29, 2018: Brain Injury: [BI]
Max Eike Timm, Omid Majdani, Tobias Weller, Mayra Windeler, Thomas Lenarz, Andreas Büchner, Rolf Benedikt Salcher
OBJECTIVES: The aim of this study was to identify anatomical indication ranges for different lateral wall cochlear implant electrodes to support surgeons in the preoperative preparation. METHODS: 272 patients who were implanted with a FLEX20, FLEX24, FLEX28, or a custom-made device (CMD) were included in this study. The cochlear duct length (CDL) and basal cochlear diameter (length A) were measured within preoperative imaging data. The parameter A was then employed to additionally compute CDL estimates using literature approaches...
2018: PloS One
Victoria S Starks, Michael K Yoon
PURPOSE: We present a series of patients with acquired obliteration of one or more components of the proximal lacrimal drainage system, including puncta and canaliculi. This finding was noted with and without other obstructions or stenoses of the lacrimal drainage system. Review of these patients in search of possible risk factors for this condition and histopathology of two patients are presented. METHODS: Medical records of patients treated at the Massachusetts Eye and Ear Infirmary between 2010 and 2016 with diagnosis codes of lacrimal punctum stenosis, stenosis of unspecified lacrimal punctum, epiphora due to insufficient drainage, and epiphora not otherwise specified were retrospectively reviewed...
October 24, 2018: Ophthalmic Plastic and Reconstructive Surgery
Vincent A Gemma, Kristina M Chapple, Pamela W Goslar, Sharjeel Israr, Scott R Petersen, Jordan A Weinberg
INTRODUCTION: Trauma centers reported illicit amphetamine use in approximately 10% of trauma admissions in the previous decade. From experience at a trauma center located in a southwestern metropolis, our perception is that illicit amphetamine use is on the rise and that these patients utilize in-hospital resources beyond what would be expected for their injuries. The purposes of this study were to document the incidence of illicit amphetamine use among our trauma patients and to evaluate its impact on resource utilization...
November 2018: Journal of Trauma and Acute Care Surgery
Omar Akhand, John-Ross Rizzo, Janet C Rucker, Lisena Hasanaj, Steven L Galetta, Laura J Balcer
BACKGROUND: Concussion leads to neurophysiologic changes that may result in visual symptoms and changes in ocular motor function. Vision-based testing is used increasingly to improve detection and assess head injury. This review will focus on the historical aspects and emerging data for vision tests, emphasizing rapid automatized naming (RAN) tasks and objective recording techniques, including video-oculography (VOG), as applied to the evaluation of mild traumatic brain injury. METHODS: Searches on PubMed were performed using combinations of the following key words: "concussion," "mild traumatic brain injury," "rapid automatized naming," "King-Devick," "mobile universal lexicon evaluation system," "video-oculography," and "eye-tracking...
October 24, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Tjokorda Gde Bagus Mahadewa, Nyoman Golden, Anne Saputra, Christopher Ryalino
Background: Traumatic brain injury (TBI) is a common healthcare problem related to disability. An easy-to-use trauma scoring system informs physicians about the severity of trauma and helps to decide the course of management. The purpose of this study is to use the combination of both physiological and anatomical assessment tools that predict the outcome and develop a new modified prognostic scoring system in TBIs. Patients and methods: A total of 181 subjects admitted to the emergency department (ED) of Sanglah General Hospital were documented for both Marshall CT scan classification score (MCTC) and Revised Trauma Score (RTS) upon admission...
2018: Open Access Emergency Medicine: OAEM
Yuan Fang, Hsiangyu Ku, Yiwen Liu, Dekang Gan
Background: Several new instruments and techniques for pars plana vitrectomy (PPV) have been widely used in recent years, but information about the related characteristics of PPV in China is limited. To investigate the trends in the characteristics of PPV in Eastern China, an 8-year retrospective study was conducted. Patients and methods: We collected data from patients who underwent PPV at the Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China, in November 2007, November 2011, and November 2015...
2018: Clinical Ophthalmology
Yassine Rabhi, Makrem Mrabet, Farhat Fnaiech
BACKGROUND AND OBJECTIVES: In order to improve assistive technologies for people with reduced mobility, this paper develops a new intelligent real-time emotion detection system to control equipment, such as electric wheelchairs (EWC) or robotic assistance vehicles. Every year, degenerative diseases and traumas prohibit thousands of people to easily control the joystick of their wheelchairs with their hands. Most current technologies are considered invasive and uncomfortable such as those requiring the user to wear some body sensor to control the wheelchair...
October 2018: Computer Methods and Programs in Biomedicine
Tugba Dursun Usal, Deniz Yucel, Vasif Hasirci
Damage to the nervous system due to age, diseases or trauma may inhibit signal transfer along the nervous system. Nerve guides are used to treat these injuries by bridging the proximal and the distal end together. The design of the guide is very important for the reconnection of the severed axons. Methacrylated gelatin-poly(2-hydroxyethylmethacrylate) (GelMA-pHEMA) hydrogel was produced as the outer part of the nerve guide. pHEMA was added in various amounts into GelMA and increased the mechanical strength which is needed for the suturability of the guide...
October 15, 2018: International Journal of Biological Macromolecules
Lindsey L Perea, Joshua P Hazelton, Nicole Fox, John P Gaughan, John Porter, Anna Goldenberg
OBJECTIVES: Vascular injury in pediatric trauma patients is uncommon but associated with a reported mortality greater than 19% in some series. The purpose of this study was to characterize pediatric major vascular injuries (MVIs) and analyze mortality at a high-volume combined adult and pediatric trauma center. METHODS: A retrospective review (January 2000 to May 2016) was conducted of all pediatric (<18 years old) trauma patients who presented with a vascular injury...
October 17, 2018: Pediatric Emergency Care
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