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https://www.readbyqxmd.com/read/28743043/neurotrophy-and-immunomodulation-of-induced-neural-stem-cell-grafts-in-a-mouse-model-of-closed-head-injury
#1
Mou Gao, Hui Yao, Qin Dong, Yan Zhang, Yang Yang, Yihua Zhang, Zhijun Yang, Minhui Xu, Ruxiang Xu
Closed head injury (CHI) usually results in severe and permanent neurological impairments, which are caused by several intertwined phenomena, such as cerebral edema, blood-brain barrier (BBB) disruption, neuronal loss, astroglial scarring and inflammation. We previously reported that induced neural stem cells (iNSCs), similar to neural stem cells (NSCs), can accelerate neurological recovery in vivo and produce neurotrophic factors in vitro. However, the effects of iNSC neurotrophy following CHI were not determined...
July 18, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28742910/clinicopathological-evaluation-of-chronic-traumatic-encephalopathy-in-players-of-american-football
#2
Jesse Mez, Daniel H Daneshvar, Patrick T Kiernan, Bobak Abdolmohammadi, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Todd M Solomon, Christopher J Nowinski, Lisa McHale, Kerry A Cormier, Caroline A Kubilus, Brett M Martin, Lauren Murphy, Christine M Baugh, Phillip H Montenigro, Christine E Chaisson, Yorghos Tripodis, Neil W Kowall, Jennifer Weuve, Michael D McClean, Robert C Cantu, Lee E Goldstein, Douglas I Katz, Robert A Stern, Thor D Stein, Ann C McKee
Importance: Players of American football may be at increased risk of long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE). Objective: To determine the neuropathological and clinical features of deceased football players with CTE. Design, Setting, and Participants: Case series of 202 football players whose brains were donated for research. Neuropathological evaluations and retrospective telephone clinical assessments (including head trauma history) with informants were performed blinded...
July 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28742833/translational-approaches-to-coagulopathy-after-trauma-towards-targeted-treatment
#3
Mitchell Jay Cohen
Mitchell J. Cohen discusses why trauma care must go beyond restoring perfusion to target disorders of inflammation and coagulation in severely injured patients.
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742815/il33-mediated-ilc2-activation-and-neutrophil-il5-production-in-the-lung-response-after-severe-trauma-a-reverse-translation-study-from-a-human-cohort-to-a-mouse-trauma-model
#4
Jing Xu, Jesse Guardado, Rosemary Hoffman, Hui Xu, Rami Namas, Yoram Vodovotz, Li Xu, Mostafa Ramadan, Joshua Brown, Heth R Turnquist, Timothy R Billiar
BACKGROUND: The immunosuppression and immune dysregulation that follows severe injury includes type 2 immune responses manifested by elevations in interleukin (IL) 4, IL5, and IL13 early after injury. We hypothesized that IL33, an alarmin released early after tissue injury and a known regulator of type 2 immunity, contributes to the early type 2 immune responses after systemic injury. METHODS AND FINDINGS: Blunt trauma patients admitted to the trauma intensive care unit of a level I trauma center were enrolled in an observational study that included frequent blood sampling...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742679/delayed-treatment-of-a-posterior-cruciate-ligament-tibial-insertion-avulsion-fracture-in-a-child-with-open-physis-a-case-report-with-a-4-year-follow-up
#5
Tales M Guimarães, Paulo V P Helito, Fabio J Angelini, Marco K Demange, José R Pécora, Camilo P Helito
Posterior cruciate ligament avulsion fracture from its tibial insertion is a rare pathology in children. It is usually caused by high-energy traumas and its diagnosis is not always easy. Late diagnosis leads to late treatment, which can result in suboptimal results. We present a case of a 13-year-old boy hit by a car, who had a delay in diagnosis and treatment because of severe head trauma. The patient was treated 4 months after the trauma with open reduction and internal fixation of the avulsion fracture. After 4 years of follow-up, he has no complaints and has achieved good functional outcome...
September 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28742611/a-rare-presentation-of-a-morel-lavallee-lesion-of-the-lower-leg-successfully-treated-with-ultrasound-guided-aspiration
#6
Audrey Falconi, Holly Crellin, Chelsea Tagawa
A Morel-Lavallee lesion (MLL) is a relatively rare condition that is caused by a traumatic shearing force. This force leads to a closed degloving injury of the subcutaneous tissue and fascia that creates a potential space that can fill with lymph, blood, and necrotic fat. The MLLs are traditionally seen after high impact trauma and typically located at the greater trochanter and pelvis, although recent reports have found them to be located at the knee, thigh, and lower leg. The MLLs typically present as swelling at the site of injury, which can be difficult to differentiate from several other diagnoses...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28742078/longitudinal-changes-in-glucocorticoid-receptor-exon-1f-methylation-and-psychopathology-after-military-deployment
#7
R R Schür, M P Boks, B P F Rutten, N P Daskalakis, L de Nijs, M van Zuiden, A Kavelaars, C J Heijnen, M Joëls, R S Kahn, E Geuze, E Vermetten, C H Vinkers
Several cross-sectional studies have demonstrated the relevance of DNA methylation of the glucocorticoid receptor exon 1F region (GR-1F) for trauma-related psychopathology. We conducted a longitudinal study to examine GR-1F methylation changes over time in relation to trauma exposure and the development of post-deployment psychopathology. GR-1F methylation (52 loci) was quantified using pyrosequencing in whole blood of 92 military men 1 month before and 6 months after a 4-month deployment period to Afghanistan...
July 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28741845/self-regulation-shift-theory-a-dynamic-systems-approach-to-traumatic-stress
#8
Charles C Benight, Kotaro Shoji, Douglas L Delahanty
Self-regulation shift theory (SRST) is a threshold theory explaining self-regulation following trauma that utilizes nonlinear dynamics to capture systemic shifts in trauma adaptation. Cusp catastrophe modeling tests nonlinear changes in an outcome (e.g., posttraumatic distress) based on an identified bifurcation factor under specific conditions (i.e., asymmetry variables). We evaluated two cusp models in a motor vehicle accident (MVA) database and then confirmed findings within a similar dataset. Based on SRST, we tested coping self-efficacy (CSE) as the bifurcation factor and a set of asymmetry controlling variables...
July 25, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28741810/gender-differences-in-machine-learning-models-of-trauma-and-suicidal-ideation-in-veterans-of-the-iraq-and-afghanistan-wars
#9
Jaimie L Gradus, Matthew W King, Isaac Galatzer-Levy, Amy E Street
Suicide rates among recent veterans have led to interest in risk identification. Evidence of gender-and trauma-specific predictors of suicidal ideation necessitates the use of advanced computational methods capable of elucidating these important and complex associations. In this study, we used machine learning to examine gender-specific associations between predeployment and military factors, traumatic deployment experiences, and psychopathology and suicidal ideation (SI) in a national sample of veterans deployed during the Iraq and Afghanistan conflicts (n = 2,244)...
July 25, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28741388/comparative-proteomic-analysis-of-the-effect-of-the-four-herb-chinese-medicine-anbp-on-promoting-mouse-skin-wound-healing
#10
Li Chen, Qian Hou, Zhong-Zhi Zhou, Mei-Rong Li, Ling-Zhi Zhong, Xiang-Dong Deng, Zi-Ying Zhu, Zhong-Yi Cheng, Jun Zhu, Cong-Lian Xiang, Wen-Jun He, Xiao-Bing Fu
Traditional Chinese medicine has great potential to improve wound healing. ANBP, the mixture of 4 Chinese herbs- Agrimoniapilosa, Nelumbonucifera, Boswelliacarteri, and Pollen typhae-is effective in trauma treatment while its mechanism is still elusive. In this study, quantitative proteomics and bioinformatics analyses were performed to decipher the possible roles of ANBP in accelerated wound healing of mouse skin. Among all 3171 identified proteins, 90, 71, 80, and 140 proteins were found to be differently expressed in 6 hours, 3 days, 7 days, and 14 days ANBP-treated tissues compared with corresponding control tissues, respectively...
July 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28741326/-dislocation-of-the-proximal-hallux-interphalangeal-joint-with-interposition-of-a-sesamoid-bone-a-blibliographic-review
#11
C Arvinius, J Valle, A Urda, C León, R F Marco
The irreducible dislocation of the hallux interphalangeal joint is an infrequent condition and only a few cases have been described. It presents as dorsal dislocation with interposition of the sesamoid bone, which has the possibility of being radiologically undetectable. We present the case of a 29 year-old patient who, after a sports trauma sustained a hallux interphalangeal dislocation that went unnoticed for eight days. Since, closed reduction was not possible, as occurred in several cases reported in the literature, open reduction was performed through a dorsal incision...
January 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28741012/management-of-computed-tomography-detected-pneumothorax-in-patients-with-blunt-trauma-experience-from-a-community-based-hospital
#12
Ashraf F Hefny, Fathima T Kunhivalappil, Nikolay Matev, Norman A Avila, Masoud O Bashir, Fikri M Abu-Zidan
INTRODUCTION: With near-routine use of computed tomography (CT) for imaging trauma patients, the diagnosis of pneumothorax, especially occult pneumothorax, has increased. However, the need for chest tube insertion remains controversial. We aimed to study the management of pneumothorax detected on CT among patients with blunt trauma, including the decision for tube thoracostomy, in a community-based hospital. METHODS: Chest CT scans of patients with blunt trauma treated at Al Rahba Hospital, Abu Dhabi, from October 2010 to October 2014 were retrospectively studied...
July 25, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28739778/a-multilevel-analysis-of-risk-and-protective-factors-for-canadian-youth-injured-or-killed-by-interpersonal-violence
#13
Carolyn E Snider, Marni Brownell, Brenden Dufault, Nicole Barrett, Heather Prior, Carla Cochrane
PURPOSE: The study's purpose was to determine individual-level and neighbourhood-level risk and protective factors for severe intentional injury among youth. METHODS: We conducted a multilevel case-control study using registry data to determine individual-level and neighbourhood-level social determinants associated with severe violent injury/homicide among youth from Winnipeg, Manitoba. RESULTS: The study includes 13 206 youth, aged 12-24 years (1222 cases, 11 984 controls)...
July 24, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28739241/hospital-mortality-based-on-the-mode-of-emergency-medical-services-transportation
#14
Hassan Al-Thani, Ayman El-Menyar, Yugan Pillay, Monira Mollazehi, Ahammed Mekkodathil, Rafael Consunji
OBJECTIVE: We assessed the presentations and outcomes of trauma patients transported by helicopter emergency medical services (HEMS) versus ground emergency medical services (GEMS). METHODS: A retrospective analysis of trauma registry data at a level I trauma center was conducted for patients transported by GEMS and HEMS between 2011 and 2013. Data were analyzed and categorized based on the mode of transportation. RESULTS: A total of 4,596 trauma patients were admitted to the hospital with a mean age of 31 ± 15 years...
July 2017: Air Medical Journal
https://www.readbyqxmd.com/read/28738952/medication-errors-in-injured-patients
#15
Scott C Dolejs, Christopher F Janowak, Ben L Zarzaur
Trauma patients are vulnerable to medication error given multiple handoffs throughout the hospital. The purpose of this study was to assess trends in medication errors in trauma patients and the role these errors play in patient outcomes. Injured adults admitted from 2009 to 2015 to a Level I trauma center were included. Medication errors were determined based on a nurse-driven, validated, and prospectively maintained database. Multivariable logistic regression modeling was used to control for differences between groups...
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28738950/a-decade-evaluation-of-a-state-trauma-system-has-access-to-inpatient-trauma-care-at-designated-trauma-centers-improved
#16
Dennis W Ashley, Etienne E Pracht, Regina S Medeiros, Elizabeth V Atkins, Elizabeth G Nesmith, Tracy J Johns, James R Dunne, Jeffrey M Nicholas
Recently, the trauma center component of the Georgia trauma system was evaluated demonstrating a 10 per cent probability of increased survival for severely injured patients treated at designated trauma centers (DTCs) versus nontrauma centers. The purpose of this study was to determine the effectiveness of a state trauma system to provide access to inpatient trauma care at DTCs for its residents. We reviewed 371,786 patients from the state's discharge database and identified 255,657 treated at either a DTC or a nontrauma center between 2003 and 2012...
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28738942/in-the-modern-era-of-ct-do-blunt-trauma-patients-with-markers-for-blunt-bowel-or-mesenteric-injury-still-require-exploratory-laparotomy
#17
Katelyn Young, Melina Benson, Andrew Higgins, James Dove, Marie Hunsinger, Mohsen Shabahang, Joseph Blansfield, Denise Torres, Kenneth Widom, Jeffrey Wild
After blunt trauma, certain CT markers, such as free intraperitoneal air, strongly suggest bowel perforation, whereas other markers, including free intraperitoneal fluid without solid organ injury, may be merely suspicious for acute injury. The present study aims to delineate the safety of nonoperative management for markers of blunt bowel or mesenteric injury (BBMI) that are suspicious for significant bowel injury after blunt trauma. This was a retrospective review of adult blunt trauma patients with abdominopelvic CT scans on admission to a Level I trauma center between 2012 and 2014...
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28738937/percutaneous-tracheostomy-under-bronchoscopic-visualization-does-not-affect-short-term-or-long-term-complications
#18
Thomas S Easterday, Joshua W Moore, Meredith H Redden, David V Feliciano, Vernon J Henderson, Timothy Humphries, Katherine E Kohler, Philip T Ramsay, Stanston D Spence, Mark Walker, Amy D Wyrzykowski
Percutaneous tracheostomy is a safe and effective bedside procedure. Some advocate the use of bronchoscopy during the procedure to reduce the rate of complications. We evaluated our complication rate in trauma patients undergoing percutaneous tracheostomy with and without bronchoscopic guidance to ascertain if there was a difference in the rate of complications. A retrospective review of all tracheostomies performed in critically ill trauma patients was performed using the trauma registry from an urban, Level I Trauma Center...
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28738812/effectiveness-of-trauma-team-on-medical-resource-utilization-and-quality-of-care-for-patients-with-major-trauma
#19
Chih-Jung Wang, Shu-Ting Yen, Shih-Fang Huang, Su-Chen Hsu, Jeremy C Ying, Yan-Shen Shan
BACKGROUND: Trauma is one of the leading causes of death in Taiwan, and its medical expenditure escalated drastically. This study aimed to explore the effectiveness of trauma team, which was established in September 2010, on medical resource utilization and quality of care among major trauma patients. METHODS: This was a retrospective study, using trauma registry data bank and inpatient medical service charge databases. Study subjects were major trauma patients admitted to a medical center in Tainan during 2009 and 2013, and was divided into case group (from January, 2011 to August, 2013) and comparison group (from January, 2009 to August, 2010)...
July 24, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28738295/does-the-effect-of-one-day-simulation-team-training-in-obstetric-emergencies-decline-within-one-year-a-post-hoc-analysis-of-a-multicentre-cluster-randomised-controlled-trial
#20
J van de Ven, A F Fransen, E Schuit, P J van Runnard Heimel, B W Mol, S G Oei
Does the effect of one-day simulation team training in obstetric emergencies decline within one year? A post-hoc analysis of a multicentre cluster randomised controlled trial. J van de Ven, AF Fransen, E Schuit, PJ van Runnard Heimel, BW Mol, SG Oei OBJECTIVE: To investigate whether the effect of a one-day simulation-based obstetric team training on patient outcome changes over time. STUDY DESIGN: Post-hoc analysis of a multicentre, open, randomised controlled trial that evaluated team training in obstetrics (TOSTI study)...
July 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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