Lisa Le Gall, Jérôme Harambat, Christian Combe, Viviane Philipps, Cécile Proust-Lima, Maris Dussartre, Tilman Druëke, Gabriel Choukroun, Denis Fouque, Luc Frimat, Christian Jacquelinet, Maurice Laville, Sophie Liabeuf, Roberto Pecoits-Filho, Ziad A Massy, Bénédicte Stengel, Natalia Alencar de Pinho, Karen Leffondré, Mathilde Prezelin-Reydit
BACKGROUND: Trajectories of haemoglobin in patients with chronic kidney disease (CKD) have been poorly described. In such patients, we aimed to identify typical haemoglobin trajectory profiles and estimate their risks of major adverse cardiovascular events (MACE). METHODS: We used 5-year longitudinal data from the CKD-REIN cohort patients with moderate to severe CKD enrolled from 40 nationally representative nephrology clinics in France. A joint latent class model was used to estimate, in different classes of haemoglobin trajectory, the competing risks of (i) MACE + defined as the first event among cardiovascular death, non-fatal myocardial infarction, stroke or hospitalization for acute heart failure, (ii) initiation of kidney replacement therapy (KRT), and (iii) non-cardiovascular death...
November 3, 2023: Nephrology, Dialysis, Transplantation