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Insulin adherence type 1 diabetes

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https://www.readbyqxmd.com/read/27931254/feasibility-of-an-online-intervention-stak-d-to-promote-physical-activity-in-children-with-type-1-diabetes-protocol-for-a-randomised-controlled-trial
#1
Holly Blake, Helen Quirk, Paul Leighton, Tabitha Randell, James Greening, Boliang Guo, Cris Glazebrook
BACKGROUND: Regular physical activity has important health benefits for children with type 1 diabetes mellitus (T1DM), yet children and their parents face barriers to participation such as lack of self-efficacy or concerns around hypoglycaemia. Multimedia interventions are useful for educating children about their health and demonstrate potential to improve children's health-related self-efficacy, but few paediatric clinics offer web-based resources as part of routine care. The Steps to Active Kids with Diabetes (STAK-D) programme is an online intervention grounded in psychological theory (social cognitive theory) and informed by extensive preliminary research...
December 8, 2016: Trials
https://www.readbyqxmd.com/read/27889809/reversal-of-type-2-diabetes-in-youth-who-adhere-to-a-very-low-energy-diet-a-pilot-study
#2
Megan L Gow, Louise A Baur, Nathan A Johnson, Chris T Cowell, Sarah P Garnett
AIMS/HYPOTHESIS: The aim of the study was to investigate whether a very-low-energy diet (VLED) is a feasible and acceptable treatment option for type 2 diabetes in children and adolescents, and whether adherence can lead to rapid weight loss, reversal of type 2 diabetes and reduced liver fat as seen in adult studies. METHODS: Eight participants with type 2 diabetes and obesity, aged 7-16 years, non-medicated (n = 1) or treated with metformin (n = 7) and in some cases insulin (n = 3), followed a VLED (<3360 kJ/day) for 8 weeks, then transitioned to a hypocaloric diet (∼6300 kJ/day) that they followed to 34 weeks...
November 26, 2016: Diabetologia
https://www.readbyqxmd.com/read/27810995/a-mobile-computerized-decision-support-system-to-prevent-hypoglycemia-in-hospitalized-patients-with-type-2-diabetes-mellitus-lessons-learned-from-a-clinical-feasibility-study
#3
Stephan Spat, Klaus Donsa, Peter Beck, Bernhard Höll, Julia K Mader, Lukas Schaupp, Thomas Augustin, Franco Chiarugi, Katharina M Lichtenegger, Johannes Plank, Thomas R Pieber
BACKGROUND: Diabetes management requires complex and interdisciplinary cooperation of health care professionals (HCPs). To support this complex process, IT-support is recommended by clinical guidelines. The aim of this article is to report on results from a clinical feasibility study testing the prototype of a mobile, tablet-based client-server system for computerized decision and workflow support (GlucoTab®) and to discuss its impact on hypoglycemia prevention. METHODS: The system was tested in a monocentric, open, noncontrolled intervention study in 30 patients with type 2 diabetes mellitus (T2DM)...
November 2, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27807014/continuous-glucose-monitoring-cgm-adherence-in-youth-with-type-1-diabetes-associations-with-biomedical-and-psychosocial-variables
#4
Elisa Giani, Rebecca Snelgrove, Lisa K Volkening, Lori M Laffel
BACKGROUND: Continuous glucose monitoring (CGM) remains underutilized in youth with type 1 diabetes (T1D). There is a need to investigate factors associated with CGM use. METHOD: In 61 T1D youth, CGM use was ascertained by downloads reflecting the 4-week periods preceding 3- and 6-month study visits. Demographic and clinical data were obtained from chart review and interview. Youth and parents completed validated psychosocial surveys at baseline and 6 months. RESULTS: Youth (52% male, 93% Caucasian, 80% pump treated) were 12...
November 1, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27744013/use-of-healthcare-resources-and-costs-associated-to-the-start-of-treatment-with-injectable-drugs-in-patients-with-type-2-diabetes-mellitus
#5
Antoni Sicras-Mainar, Ruth Navarro-Artieda, Raúl Morano, Lucía Ruíz
OBJECTIVES: The main objective was to assess resource use and costs of starting treatment with insulin or injectable GLP-1 receptor analogues (GLP-1 RAs) in a Spanish population of patients with type 2 diabetes mellitus. Treatment adherence and persistence were also determined for both treatment groups. PATIENTS AND METHODS: A retrospective, non-interventional, observational study was conducted. Patients aged ≥20 years who started treatment with insulin or GLP-1 RAs in the 2010-2012 period were recruited...
December 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/27720243/quality-of-life-in-type-1-diabetes-and-celiac-disease-role-of-the-gluten-free-diet
#6
Anna Pham-Short, Kim C Donaghue, Geoffrey Ambler, Sarah Garnett, Maria E Craig
OBJECTIVE: To evaluate quality of life (QoL) and glycemic control in youth with type 1 diabetes (T1D) and celiac disease vs T1D only. We hypothesized that QoL scores would be lower in youth with T1D and celiac disease and those nonadherent to the gluten-free diet (GFD). STUDY DESIGN: This case control study included 35 youth with T1D and 35 with T1D  and  celiac disease matched for age, sex, diabetes duration, and hemoglobin A1c level. QoL was assessed in participants and parents using the Pediatric Quality of Life Inventory Generic Core Scale, Pediatric Quality of Life Inventory Diabetes Module...
October 5, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27718744/monitoring-safety-and-use-of-old-and-new-treatment-options-for-type-2-diabetic-patients-a-two-year-2013-2016-analysis
#7
Christian Leporini, Rosanna Piro, Francesco Ursini, Francesca Maida, Caterina Palleria, Franco Arturi, Maria Pavia, Giovambattista De Sarro, Emilio Russo
OBJECTIVE: To compare patients' and physicians' perceptions regarding effectiveness and tolerability of non-insulin hypoglycemic drugs in a cohort of type 2 diabetic patients; to verify whether a possible tridimensional link between effectiveness, tolerability, and adherence affects long-term therapeutic outcomes. METHODS: A two-year observational study was performed in 1389 Type 2 diabetic patients by involving general practitioner clinics and Diabetes Centers...
October 8, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27669970/intestinal-dysbiosis-gut-hyperpermeability-and-bacterial-translocation-missing-links-between-depression-obesity-and-type-2-diabetes
#8
Anastasiya Slyepchenko, Michael Maes, Rodrigo Machado-Veira, George Anderson, Marco Solmi, Yolanda Sanz, Michael Berk, Cristiano A Köhler, André F Carvalho
The comorbid prevalence of major depressive disorder (MDD) with obesity and type II diabetes mellitus reflects the existence of a subset of individuals with a complex common pathophysiology and overlapping risk factors. Such comorbid disease presentations imply a number of difficulties, including: decreased treatment responsivity and adherence; altered glycemic control and increased risk of wider medical complications. A number of factors link MDD to metabolic-associated disorders, including: higher rates of shared risk factors such as poor diet and physical inactivity and biological elements including increased inflammation; insulin resistance; oxidative and nitrosative stress; and mitochondrial dysfunction...
September 22, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27663288/psychological-factors-associated-with-diabetes-self-management-among-adolescents-with-type-1-diabetes-a-systematic-review
#9
Kelly Martinez, Sharon F Frazer, Martin Dempster, Andrea Hamill, Hanora Fleming, Noleen K McCorry
This review aims to synthesise the literature examining the psychosocial variables related to self-management (insulin adherence, non-adherence and administration, blood sugar monitoring, dietary behaviour, exercise behaviour) in adolescents with type 1 diabetes. A systematic search of three electronic databases was carried out and, after the application of eligibility criteria, 21 articles were assessed for quality prior to data extraction. Numerous psychological factors were found to be associated with self-management; however, correlations were typically small to moderate...
September 22, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27646315/real-world-clinical-outcomes-and-patient-characteristics-for-canagliflozin-treated-patients-in-a-specialty-diabetes-clinic
#10
June Felice Johnson, Rahul Parsa, Robert Bailey
OBJECTIVE: To examine characteristics and outcomes of type 2 diabetes (T2DM) patients prescribed canagliflozin (CANA) and managed in the real-world setting of a diabetes clinic. Primary outcome was change in A1c, and secondary outcomes were change in weight and blood pressure. METHODS: Study was an electronic health record (EHR) review of CANA prescribed at the diabetes clinic from June 2013 to June 2015. Patients were included in the study if they were adults with T2DM, received routine follow-up diabetes care at the diabetes clinic, received an initial prescription for CANA from a diabetes clinic prescriber, and returned for at least one follow-up office visit (OV) after initial CANA prescribing...
October 5, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27630717/mesenchymal-stem-cells-derived-from-human-exocrine-pancreas-spontaneously-express-pancreas-progenitor-cell-markers-in-a-cell-passage-dependent-manner
#11
Song Lee, Seonghee Jeong, Chanmi Lee, Jooyun Oh, Song-Cheol Kim
Mesenchymal stem cells (MSCs) derived from bone marrow, adipose tissue, and most connective tissues have been recognized as promising sources for cell-based therapies. MSCs have also been detected in human pancreatic tissue, including endocrine and exocrine cells. These adult human pancreas-derived MSCs have generated a great deal of interest owing to their potential use in the differentiation of insulin-producing cells for diabetes treatment. In the present study, we isolated MSCs from the adult human exocrine pancreas to determine whether isolated MSCs have the potential to differentiate into pancreatic endocrine cells and, therefore, whether they can be used in stem cell-based therapies...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27625706/brazilian-multicenter-study-for-the-evaluation-of-patients-satisfaction-of-blood-glucose-self-monitoring-with-bgstar-%C3%A2-blood-glucose-meter-in-insulinized-patients-with-diabetes-mellitus-type-1-and-2
#12
Miguel Nasser Hissa
BACKGROUND: Diabetes mellitus (DM) is considered a global epidemic, and patient self-management education and support are critical in preventing and reducing the risk of complications. Self-monitoring of blood glucose (SMBG) is essential for care of individuals with DM, helping patients to achieve and maintain target blood glucose levels. The purpose of this study is to compare the satisfaction of insulinized DM patients on SMBG with use of investigational blood glucose meter (BGM) versus their routine device...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27622917/diabetes-control-and-adherence-in-adolescence
#13
Christy Foster, Jayne Bellando, Yu-Chi Annie Wang
Type 1 diabetes is a chronic disease that can lead to severe complications if poorly controlled. Adolescents are particularly vulnerable to worsening diabetes control due to changes in physiology, family dynamics, and social interactions. Good diabetes control requires following a regimen of frequent blood glucose checks, accurate carbohydrate counts, and compliance with insulin administration. Patients who are challenged in controlling their diabetes do tend to respond to behavioral interventions; however, the effect of the intervention wanes over time...
September 1, 2016: Pediatric Annals
https://www.readbyqxmd.com/read/27609738/development-and-usability-of-reach-a-tailored-theory-based-text-messaging-intervention-for-disadvantaged-adults-with-type-2-diabetes
#14
Lyndsay A Nelson, Lindsay S Mayberry, Kenneth Wallston, Sunil Kripalani, Erin M Bergner, Chandra Y Osborn
BACKGROUND: Among adults with type 2 diabetes mellitus (T2DM), adherence to recommended self-care activities is suboptimal, especially among racial and ethnic minorities with low income. Self-care nonadherence is associated with having worse glycemic control and diabetes complications. Text messaging interventions are improving the self-care of adults with T2DM, but few have been tested with disadvantaged populations. OBJECTIVE: To develop Rapid Education/Encouragement And Communications for Health (REACH), a tailored, text messaging intervention to support the self-care adherence of disadvantaged patients with T2DM, based on the Information-Motivation-Behavioral skills model...
September 8, 2016: JMIR Human Factors
https://www.readbyqxmd.com/read/27587370/self-management-behaviors-in-adults-on-insulin-pump-therapy-what-are-patients-really-doing
#15
Danielle Groat, Maria Adela Grando, Hiral Soni, Bithika Thompson, Mary Boyle, Marilyn Bailey, Curtiss B Cook
BACKGROUND: Successful diabetes management requires behavioral changes. Little is known about self-management behaviors (SMB) in adults on insulin pump (IP) therapy. OBJECTIVE: Analyze and characterize observed common diabetes SMB in adult participants with type 1 diabetes (T1D) using IPs and to correlate behaviors with glycemic outcomes based on participant's individual glucose targets. MATERIALS AND METHODS: One month of IP data from adults with T1D were downloaded...
September 1, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27574743/proximal-predictors-of-long-term-discontinuance-with-noninsulin-antihyperglycemic-agents
#16
Bruce C Stuart, Xian Shen, Charlene C Quinn, Nicole Brandt, Pamela Roberto, F Ellen Loh, Franklin Hendrick, Caroline Kim, Xingyue Huang, Swapnil Rajpathak
BACKGROUND: Noninsulin antihyperglycemic agents (NAAs) are the mainstay of treatment for type 2 diabetes, yet persistence in NAA use is suboptimal in many diabetes patients. Most of the research on NAA discontinuance has focused on sociodemographic characteristics and general health status, but such factors are inherently limited in explaining dynamic events such as discontinuance. OBJECTIVE: To assess the relative importance of static and proximal dynamic factors in explaining long-term NAA discontinuance among Medicare beneficiaries with diabetes...
September 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27570448/treatment-progression-in-sulfonylurea-and-dipeptidyl-peptidase-4-inhibitor-cohorts-of-type-2-diabetes-patients-on-metformin
#17
Xiaomei Peng, Dingfeng Jiang, Dongju Liu, Oralee J Varnado, Jay P Bae
BACKGROUND: Metformin is an oral antidiabetic drug (OAD) widely used as first-line therapy in type 2 diabetes (T2D) treatments. Numerous treatment pathways after metformin failure exist. It is important to understand how treatment choices influence subsequent therapy progressions. This retrospective study compares adherence to, persistence with, and treatment progression in sulfonylurea (SU) and dipeptidyl peptidase-4 (DPP-4) inhibitor patient cohorts with T2D on metformin. METHODS: Using health insurance claims data, matched patient cohorts were created and OAD use was compared in patients with T2D initiating SU or DPP-4 inhibitors (index drugs) since January 1, 2010, to December 31, 2010, with background metformin therapy...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27543271/the-interactive-effect-of-diabetes-family-conflict-and-depression-on-insulin-bolusing-behaviors-for-youth
#18
Genevieve Maliszewski, Susana R Patton, L Kurt Midyett, Mark A Clements
OBJECTIVE: Adherence to type 1 diabetes management declines as children enter adolescence. For youth, psychosocial variables including mood and interpersonal relationships play a large role in diabetes maintenance. The current study assessed the unique and interactive roles diabetes family conflict and depression have on insulin bolusing behaviors for youth ages 10-16 years. METHODS: Ninety-one youth-parent dyads completed a survey assessing family conflict and depression...
August 18, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27513598/adherence-to-insulin-therapeutic-regimens-in-patients-with-type-1-diabetes-a-nationwide-survey-in-brazil
#19
M B Gomes, C A Negrato
AIMS: Determine the relationship between self-reported adherence to insulin therapeutic regimens in Brazilian patients with type 1 diabetes and demographic, clinical data, glycemic control and cardiovascular risk factors. METHODS: This was a cross-sectional, multicenter study conducted between August 2011 and August 2014 in 10 Brazilian cities. Data were obtained from 1698 patients, aged 30.0±11.90years (55.5% females, 53.6% Caucasians) with a diabetes duration of 15...
October 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27506126/macroporous-biohybrid-cryogels-for-co-housing-pancreatic-islets-with-mesenchymal-stromal-cells
#20
Danielle J Borg, Petra B Welzel, Milauscha Grimmer, Jens Friedrichs, Marc Weigelt, Carmen Wilhelm, Marina Prewitz, Aline Stißel, Angela Hommel, Thomas Kurth, Uwe Freudenberg, Ezio Bonifacio, Carsten Werner
UNLABELLED: Intrahepatic transplantation of allogeneic pancreatic islets offers a promising therapy for type 1 diabetes. However, long-term insulin independency is often not achieved due to severe islet loss shortly after transplantation. To improve islet survival and function, extrahepatic biomaterial-assisted transplantation of pancreatic islets to alternative sites has been suggested. Herein, we present macroporous, star-shaped poly(ethylene glycol) (starPEG)-heparin cryogel scaffolds, covalently modified with adhesion peptides, for the housing of pancreatic islets in three-dimensional (3D) co-culture with adherent mesenchymal stromal cells (MSC) as accessory cells...
October 15, 2016: Acta Biomaterialia
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