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Insulin adherence type 1 diabetes

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https://www.readbyqxmd.com/read/28235722/current-trend-in-drug-delivery-considerations-for-subcutaneous-insulin-depots-to-treat-diabetes
#1
REVIEW
Jayakrishnapillai P V, Shantikumar V Nair, Kaladhar Kamalasanan
Diabetes mellitus (DM) is a metabolic disorder due to irregularities in glucose metabolism, as a result of insulin disregulation. Chronic DM (Type 1) is treated by daily insulin injections by subcutaneous route. Daily injections cause serious patient non-compliance and medication non-adherence. Insulin Depots (ID) are parenteral formulations designed to release the insulin over a specified period of time, to control the plasma blood glucose level for intended duration. Physiologically, pancreas produces and secretes insulin in basal and pulsatile mode into the blood...
February 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28230457/comparative-effectiveness-of-rapid-acting-insulins-in-adults-with-diabetes
#2
Patrick N Racsa, Yunus Meah, Jeffrey J Ellis, Kimberly R Saverno
BACKGROUND: Although there are a variety of insulin products and new delivery modalities available, the absence of direct clinical and economic comparisons can make treatment planning and formulary decision making difficult. Direct comparisons between insulin aspart and insulin lispro from a large heterogeneous population are not available. OBJECTIVE: To assess differences in clinical outcomes, medication adherence, utilization, and total health care costs between aspart and lispro and vial versus pen modalities for administering these short-acting insulin analogs...
March 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28210522/acute-hyperglycemia-associated-with-psychotic-symptoms-in-a-patient-with-type-1-diabetes-mellitus-a-case-report
#3
Swapnajeet Sahoo, Aseem Mehra, Sandeep Grover
Although psychiatric manifestations in the form of delirium, confusional states, and psychosis have been commonly reported in relation to hypoglycemia, association of hyperglycemia with psychiatric manifestations has been less commonly reported. In this case report, we present the case of a 36-year-old woman suffering from Type 1 diabetes mellitus who developed recurrent episodes of psychosis following poor adherence to her insulin therapy, leading to significantly high levels of blood glucose. Adequate control of blood glucose levels by improving the adherence with insulin led to lack of recurrence of psychosis...
November 2016: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/28138788/young-patients-with-type-1-diabetes-poorly-controlled-and-poorly-compliant-with-self-monitoring-of-blood-glucose-can-technology-help-results-of-the-i-newtrend-randomized-clinical-trial
#4
Paolo Di Bartolo, Antonio Nicolucci, Valentino Cherubini, Diario Iafusco, Marco Scardapane, Maria Chiara Rossi
AIMS: To compare iBGStar™ + DMApp (experimental meter + telemedicine system) (iBGStar) with a traditional glucose meter (Control) in type 1 diabetes adolescents/young adults. METHODS: i-NewTrend was a multicenter, open-label, randomized trial involving subjects aged 14-24 years, on basal-bolus insulin, HbA1c ≥ 8.0%, and poorly compliant with SMBG (i.e., <30% of the recommended frequency). Primary end points were change in HbA1c and achievement of compliance with SMBG (≥30% of the recommended frequency) after 6 months...
January 30, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28114642/adherence-to-newly-prescribed-diabetes-medications-among-insured-latino-and-white-patients-with-diabetes
#5
Alicia Fernández, Judy Quan, Howard Moffet, Melissa M Parker, Dean Schillinger, Andrew J Karter
Importance: Medication adherence is essential to diabetes care. Patient-physician language barriers may affect medication adherence among Latino individuals. Objective: To determine the association of patient race/ethnicity, preferred language, and physician language concordance with patient adherence to newly prescribed diabetes medications. Design, Setting, and Participants: This observational study was conducted from January 1, 2006, to December 31, 2012, at a large integrated health care delivery system with professional interpreter services...
January 23, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28112773/combination-of-recreational-soccer-and-caloric-restricted-diet-reduces-markers-of-protein-catabolism-and-cardiovascular-risk-in-patients-with-type-2-diabetes
#6
M Vieira de Sousa, R Fukui, P Krustrup, S Dagogo-Jack, M E Rossi da Silva
BACKGROUND: Moderate calorie-restricted diets and exercise training prevent loss of lean mass and cardiovascular risk. Because adherence to routine exercise recommendation is generally poor, we utilized recreational soccer training as a novel therapeutic exercise intervention in type 2 diabetes (T2D) patients. OBJECTIVE: We compared the effects of acute and chronic soccer training plus calorie-restricted diet on protein catabolism and cardiovascular risk markers in T2D...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28099050/lipohypertrophy-in-china-prevalence-risk-factors-insulin-consumption-and-clinical-impact
#7
Linong Ji, Zilin Sun, Qifu Li, Guijun Qin, Zheng Wei, Junhao Liu, Arthi B Chandran, Laurence J Hirsch
BACKGROUND: Lipohypertrophy (LH) is a complication of insulin therapy. We assessed LH prevalence, risk factors, insulin usage, and clinical and health economic effects in China. METHODS: In four cities, 401 adult patients injecting insulin ≥1 year were surveyed for diabetes/insulin injection history and practices, pen needle reimbursement (PNR), and health resource utilization, followed by structured examination and HbA1c testing. Differences between those with and without LH were evaluated by Student's t-test or the Wilcoxon rank sum test...
January 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28086765/health-related-quality-of-life-hrqol-and-its-associated-factors-in-children-with-type-1-diabetes-mellitus-t1dm
#8
Marta Murillo, Joan Bel, Jacobo Pérez, Raquel Corripio, Gemma Carreras, Xavier Herrero, Josep-Maria Mengibar, Dolors Rodriguez-Arjona, Ulrike Ravens-Sieberer, Hein Raat, Luis Rajmil
BACKGROUND: The objective of the study was to describe the baseline health-related quality of life (HRQOL) in a cohort of children and adolescents with type 1 diabetes mellitus (T1DM), and analyze its associated clinical and sociodemographic factors, assessing HRQOL through internet. METHODS: This was a descriptive study of 136 patients with T1DM from 5 hospitals in Catalonia, Spain (72 girls, mean age 13.4 years (range 8-19). Inclusion criteria were more than 6 months from diagnosis, more than 8 years old and without cognitive problems...
January 13, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28033258/impact-of-disease-management-programs-on-metabolic-control-in-patients-with-type-1-diabetes-mellitus-a-cohort-study-in-shantou-china
#9
Kun Lin, Xiaoping Yang, Yixi Wu, Shuru Chen, Guoshu Yin, Jianjun Zhan, Chujia Lin, Wencan Xu, Yongsong Chen, Dan Lin, Peiwen Xie, Yishan Fang, Qiuqiang Lin, Shaoda Lin
The aim of this study is to evaluate the effect of diabetes disease management program (DMP) on glycemic control in type 1 diabetes mellitus (T1DM) patients in Shantou China.A sample of 240 participants recruited from 3C study Shantou subgroup was followed up in DMP for 3 years. The DMP provided self-management education, individualized therapy plan, diabetes complications screening, and laboratory examination periodical according to clinical practice guidelines. Primary outcomes were changes in hemoglobin A1C (HbA1c)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28004007/clinical-efficacy-of-two-different-methods-to-initiate-sensor-augmented-insulin-pumps-a-randomized-controlled-trial
#10
Jesus Moreno-Fernandez, Francisco Javier Gómez, Maria Ángeles Gálvez Moreno, Justo P Castaño
Aim. To analyze clinical effect of a novel approach to initiate sensor-augmented insulin pumps in type 1 diabetes mellitus (T1DM) patients through early real-time continuous glucose monitoring (RT-CGM) initiation. Methods. A 26-week pilot study with T1DM subjects randomized (1 : 1) to start RT-CGM three weeks before continuous subcutaneous insulin infusion (CGM pre-CSII) or adding RT-CGM three weeks after continuous subcutaneous insulin infusion (CGM post-CSII). Results. Twenty-two patients were enrolled with a mean age of 36...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28002970/comparison-of-medication-adherence-in-diabetes-mellitus-patients-on-human-versus-analogue-insulins
#11
Jorge Enrique Machado-Alba, Diego Alejandro Medina-Morales, Luis Felipe Echeverri-Cataño
: Objetive: This study evaluated the results of treatment adherence scales in two cohorts of patients with diabetes mellitus treated either with human or analogue insulins. METHODS: A cohort study was conducted in diabetes mellitus patients older than 18 that were being treated with human or analogue insulins. Two instruments were applied to each patient [medication possession ratio, Morisky-Green test] to evaluate treatment adherence. RESULTS: A total of 238 patients, were included...
December 26, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28001445/long-term-efficacy-and-safety-of-sensor-augmented-insulin-pump-therapy-with-low-glucose-suspend-feature-in-patients-with-type-1-diabetes
#12
Ana María Gómez, Lisseth Fernanda Marín Carrillo, Oscar Mauricio Muñoz Velandia, Martín Alonso Rondón Sepúlveda, Carol M Arévalo Correa, Edwin Mora Garzón, Maria Camila Cuervo Diaz, Diana Cristina Henao Carrillo
BACKGROUND: Literature supports short-term efficacy and safety of Sensor Augmented Insulin Pump (SAP) therapy in patients with type 1 diabetes (T1D). However, no data are available showing long-term outcomes. Our study describes the long-term outcomes of SAP therapy with low-glucose suspend feature (SAP+LGS) in hypoglycemia in a Colombian population with T1D and hypoglycemia. METHODS: A cohort study was conducted with T1D patients receiving SAP+LGS therapy who initiated this therapy because of hypoglycemia at San Ignacio University Hospital diabetes center in Bogotá, Colombia...
February 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27974312/dietary-patterns-and-cardiometabolic-and-endocrine-plasma-biomarkers-in-us-women
#13
Hala B AlEssa, Vasanti S Malik, Changzheng Yuan, Walter C Willett, Tianyi Huang, Frank B Hu, Deirdre K Tobias
BACKGROUND: Healthful dietary patterns have been associated with lower risks of type 2 diabetes and coronary artery disease, but their relations with intermediate markers of cardiometabolic and endocrine health are less established. OBJECTIVE: We evaluated the Dietary Approaches to Stop Hypertension (DASH), the alternate Mediterranean diet (aMED), and the Alternate Healthy Eating Index (aHEI) diet-quality scores with cardiometabolic and endocrine plasma biomarkers in US women...
February 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27935183/metformin-in-adults-with-type-1-diabetes-design-and-methods-of-reducing-with-metformin-vascular-adverse-lesions-removal-an-international-multicentre-trial
#14
John R Petrie, Nish Chaturvedi, Ian Ford, Irene Hramiak, Alun D Hughes, Alicia J Jenkins, Barbara E Klein, Ron Klein, Teik Chye Ooi, Peter Rossing, Naveed Sattar, Coen D A Stehouwer, Helen M Colhoun
AIMS: Cardiovascular (CV) disease is a major cause of reduced life expectancy in type 1 diabetes (T1D). Intensive insulin therapy prevents CV complications but is constrained by hypoglycaemia and weight gain. Adjunct metformin reduces insulin dose requirement and stabilizes weight but there are no data on its cardiovascular effects. We have therefore initiated an international double-blind, randomized, placebo-controlled trial (REMOVAL: REducing with MetfOrmin Vascular Adverse Lesions in type 1 diabetes) to examine whether metformin reduces progression of atherosclerosis in adults with T1D...
December 9, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27931254/feasibility-of-an-online-intervention-stak-d-to-promote-physical-activity-in-children-with-type-1-diabetes-protocol-for-a-randomised-controlled-trial
#15
Holly Blake, Helen Quirk, Paul Leighton, Tabitha Randell, James Greening, Boliang Guo, Cris Glazebrook
BACKGROUND: Regular physical activity has important health benefits for children with type 1 diabetes mellitus (T1DM), yet children and their parents face barriers to participation such as lack of self-efficacy or concerns around hypoglycaemia. Multimedia interventions are useful for educating children about their health and demonstrate potential to improve children's health-related self-efficacy, but few paediatric clinics offer web-based resources as part of routine care. The Steps to Active Kids with Diabetes (STAK-D) programme is an online intervention grounded in psychological theory (social cognitive theory) and informed by extensive preliminary research...
December 8, 2016: Trials
https://www.readbyqxmd.com/read/27889809/reversal-of-type-2-diabetes-in-youth-who-adhere-to-a-very-low-energy-diet-a-pilot-study
#16
Megan L Gow, Louise A Baur, Nathan A Johnson, Chris T Cowell, Sarah P Garnett
AIMS/HYPOTHESIS: The aim of the study was to investigate whether a very-low-energy diet (VLED) is a feasible and acceptable treatment option for type 2 diabetes in children and adolescents, and whether adherence can lead to rapid weight loss, reversal of type 2 diabetes and reduced liver fat as seen in adult studies. METHODS: Eight participants with type 2 diabetes and obesity, aged 7-16 years, non-medicated (n = 1) or treated with metformin (n = 7) and in some cases insulin (n = 3), followed a VLED (<3360 kJ/day) for 8 weeks, then transitioned to a hypocaloric diet (∼6300 kJ/day) that they followed to 34 weeks...
March 2017: Diabetologia
https://www.readbyqxmd.com/read/27810995/a-mobile-computerized-decision-support-system-to-prevent-hypoglycemia-in-hospitalized-patients-with-type-2-diabetes-mellitus-lessons-learned-from-a-clinical-feasibility-study
#17
Stephan Spat, Klaus Donsa, Peter Beck, Bernhard Höll, Julia K Mader, Lukas Schaupp, Thomas Augustin, Franco Chiarugi, Katharina M Lichtenegger, Johannes Plank, Thomas R Pieber
BACKGROUND: Diabetes management requires complex and interdisciplinary cooperation of health care professionals (HCPs). To support this complex process, IT-support is recommended by clinical guidelines. The aim of this article is to report on results from a clinical feasibility study testing the prototype of a mobile, tablet-based client-server system for computerized decision and workflow support (GlucoTab®) and to discuss its impact on hypoglycemia prevention. METHODS: The system was tested in a monocentric, open, noncontrolled intervention study in 30 patients with type 2 diabetes mellitus (T2DM)...
November 2, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27807014/continuous-glucose-monitoring-cgm-adherence-in-youth-with-type-1-diabetes-associations-with-biomedical-and-psychosocial-variables
#18
Elisa Giani, Rebecca Snelgrove, Lisa K Volkening, Lori M Laffel
BACKGROUND: Continuous glucose monitoring (CGM) remains underutilized in youth with type 1 diabetes (T1D). There is a need to investigate factors associated with CGM use. METHOD: In 61 T1D youth, CGM use was ascertained by downloads reflecting the 4-week periods preceding 3- and 6-month study visits. Demographic and clinical data were obtained from chart review and interview. Youth and parents completed validated psychosocial surveys at baseline and 6 months. RESULTS: Youth (52% male, 93% Caucasian, 80% pump treated) were 12...
November 1, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27744013/use-of-healthcare-resources-and-costs-associated-to-the-start-of-treatment-with-injectable-drugs-in-patients-with-type-2-diabetes-mellitus
#19
Antoni Sicras-Mainar, Ruth Navarro-Artieda, Raúl Morano, Lucía Ruíz
OBJECTIVES: The main objective was to assess resource use and costs of starting treatment with insulin or injectable GLP-1 receptor analogues (GLP-1 RAs) in a Spanish population of patients with type 2 diabetes mellitus. Treatment adherence and persistence were also determined for both treatment groups. PATIENTS AND METHODS: A retrospective, non-interventional, observational study was conducted. Patients aged ≥20 years who started treatment with insulin or GLP-1 RAs in the 2010-2012 period were recruited...
December 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/27720243/quality-of-life-in-type-1-diabetes-and-celiac-disease-role-of-the-gluten-free-diet
#20
Anna Pham-Short, Kim C Donaghue, Geoffrey Ambler, Sarah Garnett, Maria E Craig
OBJECTIVE: To evaluate quality of life (QoL) and glycemic control in youth with type 1 diabetes (T1D) and celiac disease vs T1D only. We hypothesized that QoL scores would be lower in youth with T1D and celiac disease and those nonadherent to the gluten-free diet (GFD). STUDY DESIGN: This case control study included 35 youth with T1D and 35 with T1D  and  celiac disease matched for age, sex, diabetes duration, and hemoglobin A1c level. QoL was assessed in participants and parents using the Pediatric Quality of Life Inventory Generic Core Scale, Pediatric Quality of Life Inventory Diabetes Module...
October 5, 2016: Journal of Pediatrics
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